ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438 292 PELSSVHPPHFFFTYRIRIEMSSsaspDAACQLDSRYWKITKGNGEEEEVRGPGVVGEYPVMMPGKVHEYASCTTFSTTS 371
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIENLG----DSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPS 76

                          90
                  ....*....|.
gi 1721898438 372 EHMEGHYTFHR 382
Cdd:pfam04379  77 GSMEGSYTMVR 87

Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane/envelope biogenesis];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438  97 SWETLKTFLSQRCPRMIASLKDGAKEEELDSIETQIGFKLPEDYRCSYRLHNGQklvvpGLMGSMALSNHYRsedLLDVE 176
Cdd:COG4282     7 SWERIEAWLAEHAPDLLAALRPGASEADIAALEAALGVELPEDLRALYRIHNGQ-----GDDALPGLFGNYR---LLSLE 78

                          90
                  ....*....|....
gi 1721898438 177 TAAGGFQQRKGMRQ 190
Cdd:COG4282    79 EILDEWEVWKELLD 92

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438 292 PELSSVHPPHFFFTYRIRIEMSSsaspDAACQLDSRYWKITKGNGEEEEVRGPGVVGEYPVMMPGKVHEYASCTTFSTTS 371
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIENLG----DSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPS 76

                          90
                  ....*....|.
gi 1721898438 372 EHMEGHYTFHR 382
Cdd:pfam04379  77 GSMEGSYTMVR 87

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438 284 VTVSTAFLPELSSVHPPHFFFTYRIRIEmssSASPDAAcQLDSRYWKITKGNGEEEEVRGPGVVGEYPVMMPGKVHEYAS 363
Cdd:COG2967     5 VSVETEYLPEQSDPEEGRYVFAYTITIE---NLGDVTV-QLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTS 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1721898438 364 CTTFSTTSEHMEGHYTFhrLANKEEVFNVLIPRFHMVCP 402
Cdd:COG2967    81 GCVLETPVGTMQGSYQM--VDEDGERFDVPIPPFSLAAP 117

Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane/envelope biogenesis];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438  97 SWETLKTFLSQRCPRMIASLKDGAKEEELDSIETQIGFKLPEDYRCSYRLHNGQklvvpGLMGSMALSNHYRsedLLDVE 176
Cdd:COG4282     7 SWERIEAWLAEHAPDLLAALRPGASEADIAALEAALGVELPEDLRALYRIHNGQ-----GDDALPGLFGNYR---LLSLE 78

                          90
                  ....*....|....
gi 1721898438 177 TAAGGFQQRKGMRQ 190
Cdd:COG4282    79 EILDEWEVWKELLD 92

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1721898438  11 LDQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLC 55
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45

A Receptor for Ubiquitination Targets;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1721898438   14 LPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWR 52
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438 292 PELSSVHPPHFFFTYRIRIEMSSsaspDAACQLDSRYWKITKGNGEEEEVRGPGVVGEYPVMMPGKVHEYASCTTFSTTS 371
Cdd:pfam04379   1 PEQSSPEEGRYVFAYTIRIENLG----DSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPS 76

                          90
                  ....*....|.
gi 1721898438 372 EHMEGHYTFHR 382
Cdd:pfam04379  77 GSMEGSYTMVR 87

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438 284 VTVSTAFLPELSSVHPPHFFFTYRIRIEmssSASPDAAcQLDSRYWKITKGNGEEEEVRGPGVVGEYPVMMPGKVHEYAS 363
Cdd:COG2967     5 VSVETEYLPEQSDPEEGRYVFAYTITIE---NLGDVTV-QLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTS 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1721898438 364 CTTFSTTSEHMEGHYTFhrLANKEEVFNVLIPRFHMVCP 402
Cdd:COG2967    81 GCVLETPVGTMQGSYQM--VDEDGERFDVPIPPFSLAAP 117

Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane/envelope biogenesis];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721898438  97 SWETLKTFLSQRCPRMIASLKDGAKEEELDSIETQIGFKLPEDYRCSYRLHNGQklvvpGLMGSMALSNHYRsedLLDVE 176
Cdd:COG4282     7 SWERIEAWLAEHAPDLLAALRPGASEADIAALEAALGVELPEDLRALYRIHNGQ-----GDDALPGLFGNYR---LLSLE 78

                          90
                  ....*....|....
gi 1721898438 177 TAAGGFQQRKGMRQ 190
Cdd:COG4282    79 EILDEWEVWKELLD 92

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1721898438  11 LDQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLC 55
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1721898438  13 QLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLC 55
Cdd:cd22137     2 QLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1721898438  11 LDQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLCS 56
Cdd:cd22093     1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1721898438  17 DPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLC 55
Cdd:cd22109     9 DALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1721898438  11 LDQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSgHNPLWRSL 54
Cdd:cd22143     2 FDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLA-LPELWRSI 44

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1721898438  14 LPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLC 55
Cdd:cd22087     4 LPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1721898438  11 LDQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLCSR 57
Cdd:cd22085     3 LNHLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFLLR 49

A Receptor for Ubiquitination Targets;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1721898438   14 LPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWR 52
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1721898438  14 LPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWR 52
Cdd:cd22148     5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1721898438   9 LVLDQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWR 52
Cdd:cd22115     2 LINKKLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1721898438  13 QLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLW 51
Cdd:cd22124     3 LLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1721898438  14 LPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNP-LWRSLC 55
Cdd:cd22113     4 LPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENSDyLWRPHC 46

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1721898438  12 DQLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSL 54
Cdd:cd22091     2 EELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1721898438  14 LPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLC 55
Cdd:cd22141     4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLL 45

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1721898438  13 QLPADPLLLVFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSLCSR 57
Cdd:cd22094     5 VLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWLPKCLR 49

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1721898438  12 DQLPaDPLLL-VFSFLDFRDLIHCSFVSRRLNQLSGHNPLWRSL 54
Cdd:cd22132     2 PLLP-DSLLLhIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44