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Conserved domains on  [gi|1678704175|ref|XP_029282777|]
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solute carrier family 2, facilitated glucose transporter member 1-like isoform X1 [Cottoperca gobio]

Protein Classification

SLC2A family MFS transporter( domain architecture ID 13024542)

SLC2A (solute carrier family 2, facilitated glucose transporter) family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of hexoses such as glucose and fructose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
13-457 0e+00

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 789.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  13 MAVGTAVIGSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRK 92
Cdd:cd17431     1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  93 NSMLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI 172
Cdd:cd17431    81 NSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 173 FGTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESKARSILVKLRGTDEVSEDMQEMKEEGQQMMR 252
Cdd:cd17431   161 FGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVYATIGAGVVNTAFTVVSLFVVERVGR 332
Cdd:cd17431   241 EKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVERAGR 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 333 RPLHLTGLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWS 412
Cdd:cd17431   321 RTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWT 400
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1678704175 413 ANFLVGMCFPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGR 457
Cdd:cd17431   401 SNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
 
Name Accession Description Interval E-value
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
13-457 0e+00

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 789.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  13 MAVGTAVIGSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRK 92
Cdd:cd17431     1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  93 NSMLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI 172
Cdd:cd17431    81 NSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 173 FGTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESKARSILVKLRGTDEVSEDMQEMKEEGQQMMR 252
Cdd:cd17431   161 FGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVYATIGAGVVNTAFTVVSLFVVERVGR 332
Cdd:cd17431   241 EKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVERAGR 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 333 RPLHLTGLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWS 412
Cdd:cd17431   321 RTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWT 400
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1678704175 413 ANFLVGMCFPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGR 457
Cdd:cd17431   401 SNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
Sugar_tr pfam00083
Sugar (and other) transporter;
17-466 1.12e-166

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 478.30  E-value: 1.12e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  17 TAVIGSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISqttLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSML 96
Cdd:pfam00083   4 VAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAA---LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  97 MANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTE 176
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 177 SVMGNAS-LWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEEsKARSILVKLRGTDEVSEDMQEMKEEGQQMMREKK 255
Cdd:pfam00083 161 LNKTSNSdGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLE-EAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 256 VTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVYATIGAGVVNTAFTVVSLFVVERVGRRPL 335
Cdd:pfam00083 240 ASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 336 HLTGLMGMAVSAVFLT-VAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSAN 414
Cdd:pfam00083 320 LLLGAAGMAICFVILGiVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLAN 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 415 FLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEIAAGF 466
Cdd:pfam00083 400 FLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
18-462 1.70e-123

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 369.36  E-value: 1.70e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINApqniIESFYNETWssRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLM 97
Cdd:TIGR00879  33 AAIGGLMFGYDTGVIGG----ALALPAFEF--KFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLI 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  98 ANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTES 177
Cdd:TIGR00879 107 IALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGK 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 178 VM-GNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINcNEESKARSILVKLRGTDEVSEDMQEMKEEGQ----QMMR 252
Cdd:TIGR00879 187 VSlNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK-GRVEEARKSLARLRGTSGEDKELLDELELIDikrsIEKR 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVTIPELFRSPM-YRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS--QPVYATIGAGVVNTAFTVVSLFVVER 329
Cdd:TIGR00879 266 SVQPSWGSLFSSTRrIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVStdHAFLVSIIVGAVNFAFTFVAIFLVDR 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 330 VGRRPLHLTGLMGMAVSAVFLT--VAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAG 407
Cdd:TIGR00879 346 FGRRPLLLIGAAGMAICLFVLGilGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAV 425
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 408 FSNWSANFLVGMCFPYVEQLCGPY-VFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:TIGR00879 426 AANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
18-462 7.11e-65

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 217.25  E-value: 7.11e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINAPQNIIESFYNEtwsSRFSEPISQTTLTALWSLSVAIFSV-GGMFGsfsvGLFVNRFGRKNSML 96
Cdd:PRK10077   17 ATLGGLLFGYDTAVISGTVESLNTVFVA---PQNLSESAANSLLGFCVASALIGCIiGGALG----GYCSNRFGRRDSLK 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  97 MANVLAFVAA------AFMGLSKLASSFEMLI---IGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGI 167
Cdd:PRK10077   90 IAAVLFFISAlgsawpEFGFTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQ 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 168 LMAQ-----IFGTESVMG-NASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINcNEESKARSILVKLRGTDEVSEDMQ 241
Cdd:PRK10077  170 LVVYfvnyfIARSGDASWlNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSR-GKQEQAEGILRKIMGNTLATQALQ 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 242 EMKeegqQMMREKKVTIPELFrspMY-RQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS--QPVYATIGAGVVNTA 318
Cdd:PRK10077  249 EIK----HSLDHGRKTGGKLL---MFgVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAStdIALLQTIIVGVINLT 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 319 FTVVSLFVVERVGRRPLHLTGLMGMAVSAvfLTVAMALLDQLKWMsyVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGP 398
Cdd:PRK10077  322 FTVLAIMTVDKFGRKPLQIIGALGMAIGM--FSLGTAFYTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAI 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678704175 399 RPAAIAVAGFSNWSANFLVGMCFP-------YVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:PRK10077  398 RGKALAIAVAAQWIANYFVSWTFPmmdknswLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEM 468
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
65-414 2.68e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.94  E-value: 2.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:COG2814    48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIA 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRGALGTLHQLGVVIGILMAQIFGTesVMGNASLWPLLLAFTLLPAVLQCVLLPLCpespryllincneeskar 224
Cdd:COG2814   125 DLVPPERRGRALGLLGAGLGLGPALGPLLGG--LLADLFGWRWVFLVNAVLALLALLLLLRL------------------ 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 225 silvklrgtdevsedmqeMKEEGQQMMREKKVTIPELFRSPMYRQPIFVAIMLqlsqQLSGINAVFYYSTRIFERAGVSQ 304
Cdd:COG2814   185 ------------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLL----GFGFFALFTYLPLYLQEVLGLSA 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 305 PVYATIGA--GVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSAVFLTVAmalldqlkwMSYVSIVAIFSFVAFFEIGP 382
Cdd:COG2814   243 SAAGLLLAlfGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA---------GSLWLLLLALFLLGFGFGLL 313
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1678704175 383 GPIPWFIVAELFSQGPRPAAIAVAGFSNWSAN 414
Cdd:COG2814   314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
 
Name Accession Description Interval E-value
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
13-457 0e+00

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 789.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  13 MAVGTAVIGSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRK 92
Cdd:cd17431     1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  93 NSMLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI 172
Cdd:cd17431    81 NSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 173 FGTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESKARSILVKLRGTDEVSEDMQEMKEEGQQMMR 252
Cdd:cd17431   161 FGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVYATIGAGVVNTAFTVVSLFVVERVGR 332
Cdd:cd17431   241 EKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVERAGR 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 333 RPLHLTGLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWS 412
Cdd:cd17431   321 RTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWT 400
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1678704175 413 ANFLVGMCFPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGR 457
Cdd:cd17431   401 SNFIVGMCFQYIANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
14-457 0e+00

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 533.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  14 AVGTAVIGSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKN 93
Cdd:cd17357     1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTLVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  94 SMLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIF 173
Cdd:cd17357    81 GLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 174 GTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESKARSILVKLRG-TDEVSEDMQEMKEEGQQMMR 252
Cdd:cd17357   161 GLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLRGiEDDVDQELEEIKKESEQMGD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQ--PVYATIGAGVVNTAFTVVSLFVVERV 330
Cdd:cd17357   241 QKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPqlAEWANLGIGIVNVLSTIVGPFLIEKV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 331 GRRPLHLTGLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSN 410
Cdd:cd17357   321 GRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVN 400
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1678704175 411 WSANFLVGMCFPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGR 457
Cdd:cd17357   401 WTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
Sugar_tr pfam00083
Sugar (and other) transporter;
17-466 1.12e-166

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 478.30  E-value: 1.12e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  17 TAVIGSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISqttLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSML 96
Cdd:pfam00083   4 VAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAA---LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  97 MANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTE 176
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 177 SVMGNAS-LWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEEsKARSILVKLRGTDEVSEDMQEMKEEGQQMMREKK 255
Cdd:pfam00083 161 LNKTSNSdGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLE-EAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 256 VTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVYATIGAGVVNTAFTVVSLFVVERVGRRPL 335
Cdd:pfam00083 240 ASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 336 HLTGLMGMAVSAVFLT-VAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSAN 414
Cdd:pfam00083 320 LLLGAAGMAICFVILGiVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLAN 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 415 FLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEIAAGF 466
Cdd:pfam00083 400 FLIGFLFPIITDAIGlGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
21-462 6.23e-165

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 474.03  E-value: 6.23e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  21 GSLQFGYNTGVINAPQNIIESFYNETWSSRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANV 100
Cdd:cd17432     9 SSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 101 LAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTESVMG 180
Cdd:cd17432    89 FAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGLRELLG 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 181 NASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESKARSILVKLRGTDEVSEDMQEMKEEGQQMMREKKVTIPE 260
Cdd:cd17432   169 NEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTVSVLE 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 261 LFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPV--YATIGAGVVNTAFTVVSLFVVERVGRRPLHLT 338
Cdd:cd17432   249 LFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKiqYVTVGTGACEVLATITCVLVIERLGRRPLLIG 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 339 GLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSANFLVG 418
Cdd:cd17432   329 GFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSNFLVG 408
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1678704175 419 MCFPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:cd17432   409 LLFPFIQEGLGAYCFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
18-462 1.70e-123

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 369.36  E-value: 1.70e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINApqniIESFYNETWssRFSEPISQTTLTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLM 97
Cdd:TIGR00879  33 AAIGGLMFGYDTGVIGG----ALALPAFEF--KFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLI 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  98 ANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTES 177
Cdd:TIGR00879 107 IALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGK 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 178 VM-GNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINcNEESKARSILVKLRGTDEVSEDMQEMKEEGQ----QMMR 252
Cdd:TIGR00879 187 VSlNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK-GRVEEARKSLARLRGTSGEDKELLDELELIDikrsIEKR 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVTIPELFRSPM-YRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS--QPVYATIGAGVVNTAFTVVSLFVVER 329
Cdd:TIGR00879 266 SVQPSWGSLFSSTRrIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVStdHAFLVSIIVGAVNFAFTFVAIFLVDR 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 330 VGRRPLHLTGLMGMAVSAVFLT--VAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAG 407
Cdd:TIGR00879 346 FGRRPLLLIGAAGMAICLFVLGilGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAV 425
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 408 FSNWSANFLVGMCFPYVEQLCGPY-VFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:TIGR00879 426 AANWLANFIVGFLFPTMLESIGVGgVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
18-453 5.80e-112

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 335.70  E-value: 5.80e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINAPQNIIESFYNETWSsrfsepisqttlTALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLM 97
Cdd:cd17315     2 AALGGLLFGYDLGVINGALLYIAKDLGFGLS------------TSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLI 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  98 ANVLAFVAAAFMGLSKlasSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTES 177
Cdd:cd17315    70 AAVLYVIGALLSALAP---NVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLAL 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 178 VMGNASLWPLLLAFTLLPAVLQCVLLPLCPESpryllincneeskarsilvklrgtdevsedmqemkeegqqmmrekkvt 257
Cdd:cd17315   147 SLSPPGWWRLMFALAAVPALLQLLLMFFLPES------------------------------------------------ 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 258 ipelfrspmyrQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAG-VSQPVYATIGAGVVNTAFTVVSLFVVERVGRRPLH 336
Cdd:cd17315   179 -----------RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAGgGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLL 247
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 337 LTGLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSANFL 416
Cdd:cd17315   248 LIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFI 327
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1678704175 417 VGMCFPY-VEQLCGPYVFIIFTVLLLGFFTFTYFKVPE 453
Cdd:cd17315   328 VGLTFLImVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
12-461 1.26e-82

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 262.51  E-value: 1.26e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  12 LMAVGTAVIGSLQFGYNTGVINAPQNIIESfynetwSSRFSEPISQTTltalWSLSVAIFSVGGMFGSFSVGLFVNRFGR 91
Cdd:cd17358     1 LLATFVANLGSFSFGIAVGWSSPALPSLMS------DNSLSLPLTVAQ----FSWFGSLLTLGALIGALLSGKLADRIGR 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  92 KNSMLMANV---LAFVAAAFmglsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGIL 168
Cdd:cd17358    71 KRTLLISAIpciLGWLLIAF------AKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGIL 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 169 MAQIFGteSVMGnaslWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESkARSILVKLRGTD-EVSEDMQEMKEEG 247
Cdd:cd17358   145 LGYVLG--SFLP----WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEE-AEKSLQFLRGKDaDISKEAAEIQEEL 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 248 QQMMREKKVTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS-QPVYATIGAGVVNTAFTVVSLFV 326
Cdd:cd17358   218 AELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGlDPNTATIIIGVVQVVGTLVATLL 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 327 VERVGRRPLHLTGLMGMAVS----AVFLTVAMALLDqLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAA 402
Cdd:cd17358   298 VDRLGRRPLLLVSAIGMGIGllalGLYFYLQEHGAL-LSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLA 376
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 403 IAVAGFSNWSANFLVGMCFPYV-EQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGRTFDE 461
Cdd:cd17358   377 GSLVTLVNWLFAFIVTKTFPFLtLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
18-453 2.01e-73

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 237.08  E-value: 2.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINApqniIESFYNETWSSrfsepisqTTLTALWSLSVAIfsVGGMFGSFSVGLFVNRFGRKNSMLM 97
Cdd:cd17359     6 AALGGLLFGYDTGVING----ALPFLQTDFNL--------TPFLEGLVVSSAL--LGAAIGALFAGRLADRFGRRKTLLI 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  98 ANVLAFVAAAfmgLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIF---- 173
Cdd:cd17359    72 SAVLFFISAL---GSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnyli 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 174 --GTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLlincneeskarsilvklrgtdevsedmqemkeegqqMM 251
Cdd:cd17359   149 anAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWL------------------------------------VS 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 252 REKKVtipelfrspmyrqpIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPV--YATIGAGVVNTAFTVVSLFVVER 329
Cdd:cd17359   193 KGKPI--------------LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAalLQTIGIGVVNVIFTIIAILLVDK 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 330 VGRRPLHLTGLMGMAVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFS 409
Cdd:cd17359   259 VGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFF 338
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1678704175 410 NWSANFLVGMCFPYVEQLCGP-YVFIIFTVLLLGFFTFTYFKVPE 453
Cdd:cd17359   339 LWIANFLVSLTFPILLAAFGLaFTFLIFAVICVLAFLFVWKFVPE 383
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
17-462 3.97e-66

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 217.99  E-value: 3.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  17 TAVIGSLQFGYNTGVIN-APQNIIESFYNETWSSRFSePISQttltalwSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSM 95
Cdd:cd17362     1 FPALGGLLFGYDIGATSgALLSITSPALSGTDWYNLS-SLQS-------GLVVSGSLLGALLGSLVAGALIDRLGRRKEL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  96 LMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGt 175
Cdd:cd17362    73 ILAALLYLVGSLVTGL---APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSG- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 176 ESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYllincneeskarsilvklrgtdevsedmqemkeegqqmmrekk 255
Cdd:cd17362   149 YAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW------------------------------------------- 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 256 vtipelfrSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS---QPVYATIGAGVVNTAFTVVSLFVVERVGR 332
Cdd:cd17362   186 --------QGNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSaasDATLVSVGLGVFKLLMTIVAVLLVDKLGR 257
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 333 RPLHLTGLMGMAVSAVFL-TVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNW 411
Cdd:cd17362   258 RPLLLGGVSGMVVSLFLLaAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNF 337
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1678704175 412 SANFLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:cd17362   338 GSNALVSLAFLPLQELIGlPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
xylE PRK10077
D-xylose transporter XylE; Provisional
18-462 7.11e-65

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 217.25  E-value: 7.11e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINAPQNIIESFYNEtwsSRFSEPISQTTLTALWSLSVAIFSV-GGMFGsfsvGLFVNRFGRKNSML 96
Cdd:PRK10077   17 ATLGGLLFGYDTAVISGTVESLNTVFVA---PQNLSESAANSLLGFCVASALIGCIiGGALG----GYCSNRFGRRDSLK 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  97 MANVLAFVAA------AFMGLSKLASSFEMLI---IGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGI 167
Cdd:PRK10077   90 IAAVLFFISAlgsawpEFGFTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQ 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 168 LMAQ-----IFGTESVMG-NASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINcNEESKARSILVKLRGTDEVSEDMQ 241
Cdd:PRK10077  170 LVVYfvnyfIARSGDASWlNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSR-GKQEQAEGILRKIMGNTLATQALQ 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 242 EMKeegqQMMREKKVTIPELFrspMY-RQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS--QPVYATIGAGVVNTA 318
Cdd:PRK10077  249 EIK----HSLDHGRKTGGKLL---MFgVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAStdIALLQTIIVGVINLT 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 319 FTVVSLFVVERVGRRPLHLTGLMGMAVSAvfLTVAMALLDQLKWMsyVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGP 398
Cdd:PRK10077  322 FTVLAIMTVDKFGRKPLQIIGALGMAIGM--FSLGTAFYTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAI 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678704175 399 RPAAIAVAGFSNWSANFLVGMCFP-------YVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:PRK10077  398 RGKALAIAVAAQWIANYFVSWTFPmmdknswLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEM 468
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
18-462 2.35e-63

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 211.34  E-value: 2.35e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINapqniieSFYNET-WSSRFSEPISQTTLTAL-WSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSM 95
Cdd:cd17356     6 VSLGGFLFGYDTGSIS-------GILNMKsFQKYFADNTGTYYPSSSrQGLIVSIVNLGSFFGALISSFLSDRIGRKKSI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  96 LMANVLAFVAAAFMGLSklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI--F 173
Cdd:cd17356    79 QIGCVIYIIGAIIQVAA--IGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCinY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 174 GTESVMGNASlWPLLLAFTLLPAVLQCVLLPLCPESPRYLlincneeskarsilvklrgtdevsedmqemkeegqqmmre 253
Cdd:cd17356   157 GTHKLDGSAQ-WRIPLGLQIVWGLLLLIGMFFLPESPRWL---------------------------------------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 254 kkvtipelfrspmyrQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQ--PVYATIGAGVVNTAFTVVSLFVVERVG 331
Cdd:cd17356   196 ---------------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGssPLLTSIILYIVNFVSTIPGLFFVDKFG 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 332 RRPLHLTGLMGM--------AVSAVFLTVAMALLDQLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAI 403
Cdd:cd17356   261 RRTCLLIGAAGMsiclfiyaAVGVRYLIPNPQSGTSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGM 340
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1678704175 404 AVAGFSNWSANFLVGMCFPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:cd17356   341 ALATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEI 399
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
18-453 3.56e-59

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 199.03  E-value: 3.56e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINAPQNIIESFYNETwssrfsepisqtTLTALW-SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSML 96
Cdd:cd17360     2 AGIGGFLFGYDTGVISGALLYIKDDLGEV------------VLSTGWqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCIL 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  97 MANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTE 176
Cdd:cd17360    70 LADALFTIGAIVMAA---APNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGA 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 177 SVMGNASlWPLLLAFTLLPAVLQCVLLPLCPESPRYllincneeskarsilvklrgtdevsedmqemkeegqqmmrekkv 256
Cdd:cd17360   147 FSYLPGG-WRWMLGLAAVPAVLQFIGLLFLPESPRW-------------------------------------------- 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 257 tiPELFRSpmyrqpIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQ---PVYATIGAGVVNTAFTVVSLFVVERVGRR 333
Cdd:cd17360   182 --PSTRRA------LIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDnqnAIWLSLIVAGTNFIFTIVGMYLIDKFGRR 253
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 334 PLHLTGLMGMAVSAVFLTVamalldqlkwmsYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSA 413
Cdd:cd17360   254 KLLLISLFGVIVALVVLAV------------WLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVF 321
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1678704175 414 NFLVGMCFPYVEQLCGPY-VFIIFTVL-LLGFFtFTYFKVPE 453
Cdd:cd17360   322 NLLVSQTFLTLTQAIGPYgTFLLFAGLaVLGLI-FIYFCVPE 362
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
18-462 3.13e-54

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 186.84  E-value: 3.13e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  18 AVIGSLQFGYNTGVINAPQNIIESfynetwssrfSEPISQTTLTALwslsVAIFSVGGMFGSFSVGLFVNRFGRKNSMLM 97
Cdd:cd17437     2 ASLNSILLGYDIGVMSGAVIFIKE----------DLKISDVQEEVL----IGSLNIISLVGSLAAGRTSDWIGRRYTIAL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  98 ANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIfgTES 177
Cdd:cd17437    68 AALIFFVGALLMGV---APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYV--SNY 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 178 VMGNASL---WPLLLAFTLLPAVLQCVLLPLCPESPRYllincneeskarsilvklrgtdevsedmqemkeegqqmmrek 254
Cdd:cd17437   143 AFSGLPLhvgWRLMLGVGAVPSLFLAIGVLAMPESPRW------------------------------------------ 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 255 kvtipelfrSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGV---SQPVYATIGAGVVNTAFTVVSLFVVERVG 331
Cdd:cd17437   181 ---------TPAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIkskDKLLLATVAVGVTKTLFILVATFLLDKVG 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 332 RRPLHLTGLMGMAVSAVFLTVAMALLD----QLKWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAG 407
Cdd:cd17437   252 RRPLLLTSTGGMTLSLTALATSLTFIDrnggGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGV 331
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 408 FSNWSANFLVGMCF-PYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:cd17437   332 VVNRLMSGTVSMTFlSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
69-461 5.32e-48

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 170.83  E-value: 5.32e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  69 AIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVlAFVAAAFMGLSklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISP 148
Cdd:cd17433    48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSV-PFIAGFTVITA--AQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAH 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 149 TSIRGALGTLHQLGVVIGILMAQIFGTesvmgnASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINcNEESKARSILV 228
Cdd:cd17433   125 PRVRGTLGSCVQLMVVIGIMGAYLAGL------VLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQ-HRRQEAMAALR 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 229 KLRGTDEVSEDmQEMKEEGQQMMREKKVTIPELfRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVYA 308
Cdd:cd17433   198 FLRGPDQGWEW-ECIGIEQSFHLEEQSFSLALL-KQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSSVA 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 309 TIGAGVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVS-AVFltvamalldqlkwmSYVSIVAIFSFVAFFEIGPGPIPW 387
Cdd:cd17433   276 SVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFStAAF--------------GWLAVGSMGFFIAGFAVGWGPIPW 341
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678704175 388 FIVAELFSQGPRPAAIAVAGFSNWSANFLVGMCFPYVEQLCGPY-VFIIFTVLLLGFFTFTYFKVPETKGRTFDE 461
Cdd:cd17433   342 LVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLMEVLSSYgTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
69-461 1.63e-42

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 156.15  E-value: 1.63e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  69 AIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISP 148
Cdd:cd17434    48 SVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGS---AQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 149 TSIRGALGTLHQLGVVIGILMAQIFGTesvmgnASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEESKARSiLV 228
Cdd:cd17434   125 PGVRGALGACPQIMAVFGSLALYALGL------LLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKA-LA 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 229 KLRGTDevsEDMQEMKEEGQQMMREKKVTIP-ELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVS-QPV 306
Cdd:cd17434   198 WLRGPN---TDYMTEFEQIKDNIRKQSSRLSwAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVIlEPK 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 307 YATIGAGVVNTAFTVVSLFVVERVGRRPLhltglmgMAVSAVFLTVAMALldqlkwMSYVSIVAIFSFVAFFEIGPGPIP 386
Cdd:cd17434   275 YDAALVGAVRLLSVAIAASLMDKAGRKIL-------LFTSAFLMFAANLS------MGLIPLIAAMLFIMGYAMGWGPIT 341
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 387 WFIVAELFSQGPRPAAIAVAGFSNWSANFLVGMCFPYVEQLCGPYV-FIIFTVLLLGFFTFTYFKVPETKGRTFDE 461
Cdd:cd17434   342 WLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVpFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
17-453 3.80e-40

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 148.94  E-value: 3.80e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  17 TAVIGSLQFGYNTGV---INAPQNIIESFYNETWSSR----------FSEPISQttltalwsLSVAIFSVGGMFGSFSVG 83
Cdd:cd17361     1 VAALGGLIFGYDIGIsggVTSMDPFLEKFFPSVYEKKkgasennyckYDDQLLQ--------LFTSSLYLAGLVASLLAS 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  84 LFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGV 163
Cdd:cd17361    73 YVTRKWGRKPSMLIGGVLFLVGAALNAA---AQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAI 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 164 VIGILMAQI--FGTESVMGNAslWPLLLAFTLLPAVLQCVLLPLCPESPRyllincneeskarsilvklrgtdevsedmq 241
Cdd:cd17361   150 TIGILIANLinYGTSKIKPNG--WRLSLGLAAVPALILLLGSLFLPETPN------------------------------ 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 242 emkeegqqmmrekkvtipelfrSPmyrqPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQ--PVYATIGAGVVNTAF 319
Cdd:cd17361   198 ----------------------SP----QLVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSdaSLISAVITGAVNVVS 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 320 TVVSLFVVERVGRRPLHLTG----LMGMAVSAVFLTVAMALLDQL-KWMSYVSIVAIFSFVAFFEIGPGPIPWFIVAELF 394
Cdd:cd17361   252 TLVSIYLVDRFGRRFLLLEGgvqmLASQVAIGILLAVKFGDGGELpKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIF 331
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 395 SQGPRPAAIAVAGFSNWSANFLVGMCFpyVEQLC----GpyVFIIFTVLLLGFFTFTYFKVPE 453
Cdd:cd17361   332 PLETRSAGQSLTVAVNFLFTFVIAQAF--LSMLCamkfG--IFLFFAGWVVVMSLFVYFLLPE 390
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
68-462 2.55e-37

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 141.09  E-value: 2.55e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  68 VAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAfmgLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEIS 147
Cdd:cd17435    42 VSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSL---LLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIA 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 148 PTSIRGALGTLHQLGVVIGILMAqiFGTESVMGNASL-WPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNeeskarsi 226
Cdd:cd17435   119 PQHRRGLLVSLNELMIVIGILLA--YISNYAFANVSNgWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDN-------- 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 227 lvklrgtdevsedmqemkeegqqmmrekkvtipelfrspmYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPV 306
Cdd:cd17435   189 ----------------------------------------MRARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNE 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 307 YATI---GAGVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSavflTVAMALldqlkWMSYVSIVAifsFVAFFEIGPG 383
Cdd:cd17435   229 AASLastGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVS----LVTMGL-----WLSLASLLV---YVAAFSIGLG 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 384 PIPWFIVAELFSQGPRPAAIAVAGFSNWSANFLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:cd17435   297 PMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGlPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
13-462 1.35e-29

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 119.52  E-value: 1.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  13 MAVGTAVIGSLQFGYNTGVINAPQNIIESFYNETWssrfsepISQTTLtalwslsVAIFSVGGMFGSFSVGLFVNRFGRK 92
Cdd:cd17436     1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLSC-------FEQEAL-------VSALLIGALLASLIGGFLIDRHGRR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  93 NSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI 172
Cdd:cd17436    67 TSILGSNLVLLAGSLILTL---AGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYA 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 173 FGTeSVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNeeskarsilvklrgtdevsedmqemkeegqqmMR 252
Cdd:cd17436   144 LNY-FFSNVLTGWRYMFGLAIIPAAIQFASILLLPKKPEVLNIKDN--------------------------------MR 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 253 EKKVtipelfrspmyrqpifVAIMLQLSQQLSGINAVFYYSTRIFERAGV---SQPVYATIGAGVVNTAFTVVSLFVVER 329
Cdd:cd17436   191 RRTL----------------VGLGLVLFQQFTGQPNVLCYASTIFRSVGFqsnSSAVLASVGLGVVKVIATLLAMLFADR 254
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 330 VGRRPLHLTGLMGMAVSAVFLTVamalldqlkWMSYVSIVAifsFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGFS 409
Cdd:cd17436   255 AGRRSLLIAGCSVMAVSVSGIGL---------WITLLCLMA---FVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSF 322
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1678704175 410 NWSANFLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPETKGRTFDEI 462
Cdd:cd17436   323 NWAANLLITLSFLDLIDVIGlSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
61-448 1.63e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 113.68  E-value: 1.63e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  61 TALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVP 140
Cdd:cd06174    30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF---APSFWLLLLGRFLLGLGSGLIDPAVL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 141 LYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRyllincnee 220
Cdd:cd06174   107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP--------- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 221 skarsilvklrgtdevsedmqemKEEGQQMMREKKVTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIFERA 300
Cdd:cd06174   178 -----------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 301 G--VSQPVYATIGAGVVNTAFTVVSLFVVERV-GRRPLHLTGLMGMAVSAVFLTVAMALLdqlkwmsyvSIVAIFSFVAF 377
Cdd:cd06174   235 GlsVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLL---------LLLLLLLLLGF 305
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 378 FEIGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSANFLVGMCFPY--VEQLCGPYVFIIFTVLLLGFFTFTY 448
Cdd:cd06174   306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFllAATFGLTGAFLVLAVLLLLAAILLL 378
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
66-461 1.29e-15

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 79.29  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  66 LSVAIFSVGGMFGSFSVGLFVNRFGRKNsMLMANVLafVAAAFMGLSKLASSFEMLIIGRFIVGLY-CGLCTGFVPLYVe 144
Cdd:TIGR00898 131 LTQSCFFVGVLLGSFVFGYLSDRFGRKK-VLLLSTL--VTAVSGVLTAFSPNYTVFLVFRLLVGMGiGGIWVQAVVLNT- 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRGALGTLHQLGVVIGILMAQIFGTeSVMGnaslWPLLLAFTLLPAVLQCVLLPLCPESPRYLLINCNEEsKAR 224
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAY-FIPD----WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIE-EAL 280
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 225 SILVKLRGTDEVSEDMQEMKEEGQQMMREKKV--TIPELFRSPMYRQPIFVAIMLQLSqqlsgiNAVFYYSTrIFERAGV 302
Cdd:TIGR00898 281 KILQRIAKINGKKLPAEVLSLSLEKDLSSSKKqySFLDLFRTPNLRKTTLCLMMLWFT------TAFSYYGL-VLDLGNL 353
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 303 SQPVYAT-IGAGVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSAVFLtvAMALLDQLKWMSYVSIVAIFSFVAFFEig 381
Cdd:TIGR00898 354 GGNIYLDlFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLL--LFVPVDLYFLRTALAVLGKFGITSAFQ-- 429
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 382 pgpIPWFIVAELFSQGPRPAAIAVAgfSNWSAnfLVGMCFPYVEQLCGPYVF---IIFTVLLLGFFTFTYFkVPETKGRT 458
Cdd:TIGR00898 430 ---MVYLYTAELYPTVVRNLGVGVC--STMAR--VGSIISPFLVYLGEKWLFlplVLFGGLALLAGILTLF-LPETKGVP 501

                  ...
gi 1678704175 459 FDE 461
Cdd:TIGR00898 502 LPE 504
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
65-414 2.68e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.94  E-value: 2.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:COG2814    48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIA 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRGALGTLHQLGVVIGILMAQIFGTesVMGNASLWPLLLAFTLLPAVLQCVLLPLCpespryllincneeskar 224
Cdd:COG2814   125 DLVPPERRGRALGLLGAGLGLGPALGPLLGG--LLADLFGWRWVFLVNAVLALLALLLLLRL------------------ 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 225 silvklrgtdevsedmqeMKEEGQQMMREKKVTIPELFRSPMYRQPIFVAIMLqlsqQLSGINAVFYYSTRIFERAGVSQ 304
Cdd:COG2814   185 ------------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLL----GFGFFALFTYLPLYLQEVLGLSA 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 305 PVYATIGA--GVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSAVFLTVAmalldqlkwMSYVSIVAIFSFVAFFEIGP 382
Cdd:COG2814   243 SAAGLLLAlfGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA---------GSLWLLLLALFLLGFGFGLL 313
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1678704175 383 GPIPWFIVAELFSQGPRPAAIAVAGFSNWSAN 414
Cdd:COG2814   314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
58-213 1.96e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.37  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  58 TTLTALWSLSVAIFsvGGMFGSFSVGLFVNRFGRKNSMLMANVLafvAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTG 137
Cdd:TIGR00895  50 DPVQLGFLFSAGLI--GMAFGALFFGPLADRIGRRRVLLWSILL---FSVFTLLCALATNVTQLLILRFLAGLGLGGLMP 124
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1678704175 138 FVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGteSVMGNASLWPLLLAF-TLLPAVLQCVLLPLCPESPRYL 213
Cdd:TIGR00895 125 NLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA--GWLIPVFGWRSLFYVgGIAPLLLLLLLMRFLPESIDFL 199
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
61-215 8.45e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.82  E-value: 8.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  61 TALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVP 140
Cdd:COG0477    48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGAL 124
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678704175 141 LYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGteSVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLI 215
Cdd:COG0477   125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLG--GLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
65-217 2.77e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 58.36  E-value: 2.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSKlasSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:cd17317    28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP---SYELFLVLRFLVGVTSAGIFTVGFVLGM 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1678704175 145 EISPTSIRGALGTLHQLGVVIGI----LMAQIFGTesvmgnaslWPLLLAFTLLPAVLqcvLLPLCPESPRYLLINC 217
Cdd:cd17317   105 EIVGPKYRSFVGILFGLFWALGYmllaLLAYLIRD---------WRWLQLAISLPGLL---FLLLLWWLPRRTIIVG 169
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
72-463 6.17e-09

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 58.20  E-value: 6.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  72 SVGGMFGSFSVGLFVNRFGRK---NSMLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGlctGFVPL---YVEE 145
Cdd:TIGR00887  66 SIGTLAGQLFFGWLADKLGRKrvyGMELIIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIG---GDYPLsaiITSE 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 146 ISPTSIRGAL----------GTLhqLGVVIGILMAQIFG--------TESVMGNAS-----LWPLLLAFTLLPAVLQCVL 202
Cdd:TIGR00887 143 FATKKWRGAMmaavfamqgfGIL--AGAIVALIVLAGFKhsleaaadEASCTGSCVpavdyMWRILIGFGAVPALLALYF 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 203 LPLCPESPRY-LLINCNEESKARSILVKLRGTDEVSEDMqemKEEGQQMMREKKVTIPELFRSpmYRQPIFVAIMLQLSQ 281
Cdd:TIGR00887 221 RLTIPETPRYtADVAKDVEQAASDMSAVLQVKIEAEPDE---VEKASTAVEVPKASWSDFFTH--FFKWRHGKHLLGTAG 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 282 QLSGINAVFY----YSTRIFERAGVSQP---------VYAT-IGAGVVNTAFTV----VSLFVVERVGRRPLHLTGLmgm 343
Cdd:TIGR00887 296 SWFLLDIAFYgvnlNQKVILSAIGYSPPaatnnayeeLYKTaVGNLIIALAGTVpgywVTVFLVDIIGRKPIQLMGF--- 372
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 344 avsaVFLTVAMALLD-QLKWMSYVSIVAIFSFVAFFE-IGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWSANFLVGMCF 421
Cdd:TIGR00887 373 ----FILTVLFFVLGfAYNHLSTHGFLAIYVLAQFFAnFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGF 448
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 422 PYVEQLCGP-----------YVFIIFTVLLLGFFTFTyFKVPETKGRTFDEIA 463
Cdd:TIGR00887 449 LYLAQHGDPtkgyptgiwmgHVLEIFALFMFLGILFT-LLIPETKGKSLEELS 500
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
66-395 8.21e-09

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 57.54  E-value: 8.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  66 LSVAIFSVGGM---FGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSKLASSFE-----MLIIGRFIVGLYCGLCTG 137
Cdd:cd17369    45 AAFATFGVGFLarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIGilapiLLVLLRLLQGLALGGEWG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 138 FVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQ--IFGTESVMGNASL----W--PLLLAFTLLpavlqcvllplcpes 209
Cdd:cd17369   125 GAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATgvFLLLSALLSDEAFlswgWriPFLLSAVLV--------------- 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 210 pryllincneeskARSILVKLRGTDevSEDMQEMKEEGQQmmreKKVTIPELFRSpmYRQPIFVAIMLQLSQQ-LSGINA 288
Cdd:cd17369   190 -------------AVGLYIRLRLEE--TPVFRRAKEAGQV----VRAPLVEVLRR--HWRALLLAIGLRLAENvLFYLFT 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 289 VF--YYSTRIferAGVSQPVYATIG--AGVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSAVFLtvaMALLDQLKWMS 364
Cdd:cd17369   249 TFalSYATQT---LGVDRSTVLLAVliASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPF---FWLLDTGSTWL 322
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1678704175 365 YVsIVAIFSFVAFFEIGPGPIPWFIvAELFS 395
Cdd:cd17369   323 IV-LAAVVVLGVLHGMMYGPQAAFL-AELFP 351
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
65-198 1.92e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 56.07  E-value: 1.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSkLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:cd17316   216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYL-LSGSPTLLLLLLFILSFFVGGVWGALYAYLA 294
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 145 EISPTSIRG-ALGTLHQLGVVIGILMAQIFGTESV-MGNASLWPLLLAFTLLPAVL 198
Cdd:cd17316   295 ELFPTEVRAtGVGLSYNLGRLGGGGAPPLIALLLAsTGGTGVPALILALLAIVALI 350
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
58-198 9.39e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 53.76  E-value: 9.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  58 TTLTALWSLSVAIFsvGGMFGSFSVGLFVNRFGRKnSMLMANVLAFVAAAFmgLSKLASSFEMLIIGRFIVGLYCGLCTG 137
Cdd:cd17316    34 SLLQTGLLFAAGFL--GRPIGALLFGYLGDRIGRK-KALILTLLLFGLATL--LIGLLPTPILLLVLRFLQGIGIGGEYP 108
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 138 FVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI--FGTESVMGNASLWPLLLAFTLLPAVL 198
Cdd:cd17316   109 GASTYVAEFAPSKRRGFALGLLQSGWALGALLAALvaSLLIPLLSGDWGWRILFLIGALPALL 171
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
65-449 1.28e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.73  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:COG2223    43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA---LAVSYWLLLLLGLLLGIGGGGSFAVGIALVS 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRG-ALGTLH---QLGVVIG-ILMAQIFGTESVMGNASLWPLLLAFTLLPAVLQcvllplcpespryllincne 219
Cdd:COG2223   120 KWFPPDRRGlALGLAAgggNLGAAVAaFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLF-------------------- 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 220 eskarsilvklrgtdevsedmqeMKEEGQQMMREKKVTIPELFRspMYRQPIFVAIMLQLSQQLSGINAVFYYSTRIF-E 298
Cdd:COG2223   180 -----------------------LRDPPAGAAAAAKASLRDQLE--ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 299 RAGVSQPVYATIGA--GVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSAVFLTVAMALLdqlkwmsYVSIVAIFSFVA 376
Cdd:COG2223   235 QFGLSAATAGLLAAlfALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSL-------WLFLVLFLLLGL 307
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678704175 377 FFEIGPGPIPWFiVAELFSQGPRPAAIAVAGFSNWSANFLVGMCFPYVEQLCGPY--VFIIFTVLLLGFFTFTYF 449
Cdd:COG2223   308 ALGGGNGAVFAL-VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtaAFLVFAVLALVALVLTLL 381
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
65-194 1.37e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLmanVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLL---VLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRG----------ALGTLhqLGVVIGILMAQIFGTESVMGNASLWPLLLAFTLL 194
Cdd:cd17324   114 DLVPPEKRGraiglvfsglTLGLV--LGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLW 171
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
68-455 4.10e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.18  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  68 VAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEIS 147
Cdd:COG2271    51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 148 PTSIRGALGTLHQLGVVIGILMAQIFGTesVMGNASLWPLLLAFTLLPAVLQCVLlplcpespryllincneeskarsil 227
Cdd:COG2271   128 PPKERGRALGIFNAGGPLGGALAPPLLG--WLLAAFGWRAAFLILGLPGLLLALL------------------------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 228 vklrgtdevsedmqemkeegqqmmrekkvtipelfrspmyrqPIFVAIMLQLSQQLSGINAVFYYSTRIFERAGVSQPVY 307
Cdd:COG2271   181 ------------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 308 ATIGA--GVVNTAFTVVSLFVVERVGRRplhltGLMGMAVSAVFLTVAMALLDQlkWMSYVSIVAIFSFVAFFEIGPGPI 385
Cdd:COG2271   219 GLLLSlpFLAGIVGSLLGGWLSDRLGRR-----RKLVLAIGLLLAALALLLLAL--LPSPALAIALLFLAGFGLGGAFGL 291
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678704175 386 PWFIVAELFSQGPRPAAIAVAGFSNWSANFLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPETK 455
Cdd:COG2271   292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALLLLRETR 362
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
26-454 4.27e-07

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 51.89  E-value: 4.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  26 GYNTGVINAPQNIIESFYnetwssrFSEPISQTTLTAlwSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVA 105
Cdd:cd17364    12 AYDLFSISLVTKILGRLY-------YGGKGSLPSGVS--GLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 106 AAFMGLS---KLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGAL----------GTLhqLGVVIGILMAQI 172
Cdd:cd17364    83 TILSALSpgsTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavfamqgfGIL--AGAIVTLILSAI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 173 FGTESVMGNAS----LWPLLLAFTLLPAVLqcVLLPlcpesPRYLLINCneeskarsilvklrgtdevsedmqemkeegq 248
Cdd:cd17364   161 FEHPLPAGTYHhadlVWRIVLGLGAIPALS--VLYF-----RKHLLGTA------------------------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 249 qmmrekkvTIPELFRSPMYRQPIFVAIMLQLSQQLSGINAvfyysTRIFERAGVSQPVYAtiGAGVVNTAFtvVSLFVVE 328
Cdd:cd17364   203 --------GTWFLLDIAFYGQNLFQSTIISAIGFSKTMNA-----YQELFNIAVGQLIIA--LAGTVPGYW--FTVFLID 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 329 RVGRRPLHLTGLMGMavsAVFLTVAMALLDQLKwMSYVSIVAIFSFVAFF-EIGPGPIPWFIVAELFSQGPRPAAIAVAG 407
Cdd:cd17364   266 RIGRKKIQMMGFFGM---TIFLLILAGPYDHWK-ISTIGFFVLYGLTFFFsNFGPNTTTFIVPAEVFPARVRSTCHGISA 341
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1678704175 408 FSNWSANFLVGMCFPYVEQLCG-PYVFIIFTVLLLGFFTFTYFKVPET 454
Cdd:cd17364   342 ASGKIGAIVGSFLFLSLTQNIGvRNVLIILAGVALLGIILTLLFPEEK 389
MFS_1 pfam07690
Major Facilitator Superfamily;
65-416 4.55e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 4.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL---FASSLWLLLVLRVLQGLGAGALFPAALALIA 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRGALGTLHQLGVVIGILMAQIFGteSVMGNASLWPLLLAFTLLPAVLqcvllplcpespryllincneeskar 224
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLG--GLLASLFGWRAAFLILAILSLL-------------------------- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 225 SILVKLRGTDEvsedmqemKEEGQQMMREKKVTIPELFRSPMYRQPIFVAIMLQLSQQLsGINAVFYYSTRIFERAGVSQ 304
Cdd:pfam07690 164 AAVLLLLPRPP--------PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGF-AFFGLLTYLPLYQEVLGLSA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 305 PVYATIGA--GVVNTAFTVVSLFVVERVGRRPLHLTGLMGMAVSAVFLTVAMALLdqlkwmSYVSIVAIFSFVAFFEIGP 382
Cdd:pfam07690 235 LLAGLLLGlgGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL------SSLWLLLALLLLGFGFGLV 308
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1678704175 383 GPIPWFIVAELFSQGPRPAAIAVAGFSNWSANFL 416
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
65-211 5.54e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 5.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMAnVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:COG2271   219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1678704175 145 EISPTSIRG-ALGTLHQLGVVIGILMAQIFGTesVMGNASLWPLLLAFTLLPAVLQCVLLPLCPESPR 211
Cdd:COG2271   298 ELFPKKARGtASGLVNTFGFLGGALGPLLVGY--LLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
56-455 2.30e-06

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 49.99  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  56 SQTTLTALWSlSVAIFSVGGM---FGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFE--------MLIIG 124
Cdd:cd17367    32 SGDPTVALLS-TAAVFAVGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIA---VTPTYAtigiwapiILLLA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 125 RFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQLGVVIGILMAQI--FGTESVMGNASL--WPLLLAFtLLPAVLQC 200
Cdd:cd17367   108 RLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGvlLVLQHTLGEDQMaaWGWRIPF-LLGGVLAV 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 201 VLLPLcpespryllincneeskarsilvkLRGTDEVSEDMQEMKEEgqqmmREKKVTIPELFrspmyRQPIFVAIMLQLS 280
Cdd:cd17367   187 VVLWL------------------------RRGLEETESFEAIAESN-----EASAGTLRELR-----RHPRELLLVVGLT 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 281 qqlSGINAVFYYSTriferagVSQPVYATIGAGV---VNTAFTVVSLFVV-----------ERVGRRPLHLTGLMGMAVS 346
Cdd:cd17367   233 ---AGGTLAFYTWT-------TYLQKFLVNTAGFskgDATWITTAALLVFmllqplggrlsDRIGRRPLLLFFGIGGTLA 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 347 AVFLTVAMALLDQLkWMSYVSIVAIFSFVAFFEigpgPIPWFIVAELFSQGPR------PAAIAVAGFSNwSANFLVgmc 420
Cdd:cd17367   303 TVPLLSALDHTDSP-YTAFALVLVGLVFLSGYT----SINAVVKAELFPTHVRalgvglPYALAVAIFGG-TAPYVA--- 373
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1678704175 421 fPYVEQLCGPYVFIIFTVLLLGFFTFTYFKVPETK 455
Cdd:cd17367   374 -LWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
63-215 4.47e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.73  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  63 LWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSklaSSFEMLIIGRFIVGLYCGlCTGFVPLY 142
Cdd:cd17330    35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS---RNLWLLFLARFLDGLTGG-NVSVAQAY 110
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1678704175 143 VEEISPTSIR----GALGTLHQLGVVIGILMAQIFGTESVMgnasLWPLLLAFTLlpAVLQCVLLPLCPESPRYLLI 215
Cdd:cd17330   111 IADITDEEERakafGIISAAFGLGFILGPALGGFLSTPYGY----ALPFLVAAAL--ALLNLVLVLFFLPPLRRLLL 181
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
59-198 5.02e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 48.35  E-value: 5.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  59 TLTALWSLSVA----IFS---VGGMFGSFSVGLFVNRFGRKNSMLMAnVLAFvaAAFMGLSKLASSFEMLIIGRFIVGLY 131
Cdd:cd17365    24 ALAQDWGLSPAqlgpVGSaalFGMAIGALLAGPLADRFGRKRVLLVS-VALF--GLFTLLTAFAQSVLQLALLRFLTGLG 100
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678704175 132 CGLCTGFVPLYVEEISPTSIRGALGTLHQLGV--------VIGILMAQIFGTESVMGNASLWPLLLAFTLLPAVL 198
Cdd:cd17365   101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYplgaalggFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTLL 175
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
65-376 5.19e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.70  E-value: 5.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:COG0738    46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA---LAPSYPLLLLALFLLGLGLGLLDVAANPYVA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 145 EISPTSIRGALGTLH---QLGVVIGILMAQIFgteSVMGNASLWPLLLAFTLLPAVLQCVLLplcpespryllincnees 221
Cdd:COG0738   123 ALGPETAASRLNLLHaffSLGALLGPLLGGLL---ILLGLSLSWHLPYLILAVLLLLLALLF------------------ 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 222 karsILVKLRGTDEVSEDmqemkeegqqmMREKKVTIPELFRSPMYRQPIFVAIMLQLSQQlsginAVFYYSTRIFERAG 301
Cdd:COG0738   182 ----LRSKLPEIEEEEEE-----------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG-----AIGDWLPLYLKDVL 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1678704175 302 VSQPVYATIGAGVVNTAFTV---VSLFVVERVGRRPLhltgLMGMAVSAVFLTVAMALLDQLkWMSYVSIVAIFSFVA 376
Cdd:COG0738   242 GLSEATAALGLSLFWGGMTIgrfLGGFLLKRFGPVRL----LRLSALLAAVGLLLALLAPGP-WLALIGLALVGLGLS 314
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
62-204 8.23e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  62 ALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFEMLIIGRFIVGLYCGLCTGFVPL 141
Cdd:cd17325    31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA---FATSYWQLLLARFLQGLASAAVWPAAMA 107
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678704175 142 YVEEISPTSIRG-ALGTLHQ-------LGVVIGILMAQIFGTESVMGnaslwpLLLAFTLLPAVLQCVLLP 204
Cdd:cd17325   108 LIADIAPPEERGrAMGIFSSaiglgflIGPLLGGLLADALGYRAPFL------VCAALALLALVLALLLLP 172
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
59-406 1.28e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.30  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  59 TLTALWSLS-------VAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAfvaAAFMGLSKLASSFEMLIIGRFIVGLy 131
Cdd:cd17371    24 ALIAEFGLDeaeagllGTVTLAGGAIGGILGGILADRFGRVRVLVITILLF---AVFTLLCGFAQNYWQLLILRALAGL- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 132 cGLCTGFV--PLYVEEISPTSIRGALGTLHQLGVVIGILMAQIFGTE--SVMGNASLWPLLLAFTLLPAVLQCVLLPLCP 207
Cdd:cd17371   100 -GFGGEWAagAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALlfPLLPPEIAWRVLFLLGALPALLVLFIRRFVK 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 208 ESPRYllincneeskarsilvklrgtdevsedmQEMKEEGQQMmrEKKVTIPELFRSPMYRQPIFVAIMlqlsqqLSGIN 287
Cdd:cd17371   179 EPPQW----------------------------QAARAARRHF--ADRPSLRELFSPPLLRTTLLASLL------ATGAL 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 288 AVFYYSTRIFERAGVSQPVYATIGAGVVNTAFTVVSL-------FVVERVGRRPLHLTGLMGMAVSAVFLTVAMALLDQL 360
Cdd:cd17371   223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFlgylaggFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLI 302
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1678704175 361 KWmsyvsivaIFSFVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVA 406
Cdd:cd17371   303 LI--------LGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFC 340
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
66-210 6.20e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.28  E-value: 6.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  66 LSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLsklASSFEMLIIGRFIVGLYCGLCTGFVPLYVEE 145
Cdd:cd17489    35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL---ATSVALLLVLRLIHGIGWGAFTTAAATLVAD 111
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1678704175 146 ISPTSIRGALGTLHQLGVVIGILMAQIFGTeSVMGNASLWPL--LLAFTLLPAVLQCVLLPLCPESP 210
Cdd:cd17489   112 IIPPSRRGEGIGYYGLATTLAMALGPALGL-FLYQHLGFAVLfiVAAVLALLALLLVFLVKDPPPVA 177
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
66-170 6.33e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 45.26  E-value: 6.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  66 LSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLmANVLAFVAAAFmgLSKLASSFEMLIIGRFIVGLycGLCTGFVplyvee 145
Cdd:cd17320    38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLL-AGLLLFILASL--LCALASSIEQLLIARFLQGL--GAAAGSV------ 106
                          90       100
                  ....*....|....*....|....*
gi 1678704175 146 ISPTSIRGALGTlHQLGVVIGILMA 170
Cdd:cd17320   107 VARAIVRDLYSG-AELAKIFSLLMM 130
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
70-214 1.29e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 44.53  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  70 IFSVGGMFGSFSVGLFVNRFGRKNSMLMAnvLAfVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPT 149
Cdd:cd17438    42 IVYLGMMAGAFIWGGLADKLGRKRCLIIS--LA-INASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAR 118
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 150 SIRGA----LGTLHQLGVVIGILMA----QIFGTESVMGNA---SLWPLLLAFTLLPAVLQCVLLPLCPESPRYLL 214
Cdd:cd17438   119 EKRGEhlswLCMFWMIGGLYASAMAwsiiPHYGWGFSMGTNyhfHSWRVFVIICALPCIASIIALKFMPESPRFLL 194
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
70-216 1.38e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.58  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  70 IFSVGGMFGSFSVGLFVNRFGRKNSMLMAnvlAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPT 149
Cdd:TIGR01299 210 IVYLGMMVGAFFWGGLADKLGRKQCLLIC---LSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQ 286
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1678704175 150 SIRGA-LGTLHQLGVVIGILMAQI-------FGTESVMGNA---SLWPLLLAFTLLPAVLQCVLLPLCPESPRYLLIN 216
Cdd:TIGR01299 287 EKRGEhLSWLCMFWMIGGIYAAAMawaiiphYGWSFQMGSAyqfHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLEN 364
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
70-214 1.46e-04

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 44.40  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  70 IFSVGGMFGSFSVGLFVNRFGRKNSMLMAnvLAfVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPT 149
Cdd:cd17363    42 IVYLGMMVGAFVWGGLADKLGRKQCLLIA--LS-VNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAR 118
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678704175 150 SIRGA----LGTLHQLGVVIGILMAQI----FGTESVMGNA---SLWPLLLAFTLLPAVLQCVLLPLCPESPRYLL 214
Cdd:cd17363   119 EKRGEhlswLCMFWMIGGLYASAMAWAiiphYGWGFSMGTAyqfHSWRVFVIVCALPSVASVVALTFMPESPRFLL 194
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
65-194 1.83e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.72  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKnsMLMANVLAFVAAAFMGLSkLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:cd17473   236 GLALAIASLAGAIGALLFGRLKRRLGKR--RLLAIGFALMALGFLLLA-LASGLWVVLLGAILAGLGFGLLLPTLNSWAM 312
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1678704175 145 EISPTSIRGALGTLHQLG---------VVIGILMAQIFGTESVMGNASLWPLLLAFTLL 194
Cdd:cd17473   313 SLVPPELRGRAMGIVTSAfflgqflspLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
69-214 3.12e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 43.36  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  69 AIFSVGGMFGSFSVGLFVNRFGRKNSMLmanVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISP 148
Cdd:cd17440    41 SIVYLGMMVGAFFWGGLADKVGRRQSLL---ICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLA 117
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1678704175 149 TSIRGA-LGTLHQLGVVIGILMAQI-------FGTESVMGNA---SLWPLLLAFTLLPAVLQCVLLPLCPESPRYLL 214
Cdd:cd17440   118 REKRGEhLSWLCMFWMIGGIYASAMawaiiphYGWSFSMGSAyqfHSWRVFVIVCALPCVSSVVALTFMPESPRFLL 194
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
66-169 7.14e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 41.57  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  66 LSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSKlasSFEMLIIGRFIVGLYC--GLCTGFVplYV 143
Cdd:cd17379    37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSP---NYPWFLIFRFLQGLFGkgGWMTGYV--LV 111
                          90       100
                  ....*....|....*....|....*.
gi 1678704175 144 EEISPTSIRGALGTLHQLGVVIGILM 169
Cdd:cd17379   112 TEFVGSKYRRTVGIVYQMFFTLGLLI 137
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
61-194 8.13e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.79  E-value: 8.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  61 TALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKnsmLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVP 140
Cdd:cd17325   234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRK---PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL 310
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1678704175 141 LYVEEISPTSIRGA----LGTLHQLGVVIGILMA----QIFGTESVMGNASLWPLLLAFTLL 194
Cdd:cd17325   311 ALLADIVPPEGRGTamglFNTAFSLGMVLGPLLGgflyDAFGFATPFLAAAALLLLAAVLFL 372
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
61-198 8.97e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 8.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  61 TALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSKlASSFEMLIIGRFIVGLYCGLCTGFVP 140
Cdd:COG2211   263 AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG-PGNLWLLLVLAALAGIGLGAILVLPW 341
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678704175 141 LYVEEISP--------------TSIRGALGTLHQL--GVVIGILMAQI-FGTESVMGNASLWPLLLAFTLLPAVL 198
Cdd:COG2211   342 AMLADVVDydewktgrrreglyFGIFTFAIKLGQAlaGALAGLLLALFgYVAGAAQSPSALTGIRLLFFLLPAVL 416
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
65-213 1.11e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 41.34  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFsVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFvaaaFMG-LSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYV 143
Cdd:cd17441    38 LLTSVVF-IGMMLSSSLWGNISDQYGRKTGLKISVLWTL----YYGiLSAFAPIYSWILVLRGLVGFGIGGVPQSVTLYA 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 144 EEIsPTSIRG----------ALGTLHQlgVVIGILMAQIFGtesvmgnaslWPLLLAFTLLPAVLQCVLLPLCPESPRYL 213
Cdd:cd17441   113 EFL-PMKSRAkcillievfwALGTVFE--VLLAVFVMPTLG----------WRWLLILSALPLLIFAVLCFWLPESARYW 179
MFS_1 pfam07690
Major Facilitator Superfamily;
65-170 1.37e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
                          90       100
                  ....*....|....*....|....*.
gi 1678704175 145 EISPTSIRGALGTLHQLGVVIGILMA 170
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALG 343
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
65-194 2.00e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.23  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMglskLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:cd17478   233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF----LLTPGIWSYILLVLAGFLLFASFPVTVVLAQ 308
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 145 EISPTSIR-------------GALGTlhqlgVVIGILmAQIFGTESVMGNASLWPLLLAFTLL 194
Cdd:cd17478   309 ELLPGNVGlasglmmglsfglGGIGA-----PVLGAL-ADAFGLESVLLILALLPLLGALLAF 365
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
71-205 3.66e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 39.65  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  71 FSVGGMFGSFSVGLFVN-RFGRKNSMLMANVLAFVAAAFMGLSklaSSFEMLIIGRFIVGLYC---GLCTgFVpLYVEEI 146
Cdd:cd17378    42 FFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFS---PNYWVYAFLRFLTGFGRsgiGTCA-LV-LATEPV 116
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678704175 147 SPTSiRGALGTLHQLGVVIGILmaqifgTESVMG--NASLWPLLLAFTLLPAVLQCVLLPL 205
Cdd:cd17378   117 GPKW-RGQVGMSTFFFFVLGFM------SLPGIAylNGSSWRVLYFWTSIPALIYCILVYL 170
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
65-381 5.74e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 5.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFEMLIIGRFIVGLYCGLctgFVPL--- 141
Cdd:cd17329    38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG---FAHSPWLFAIALVLTGFGGGL---FEPAsea 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 142 YVEEISPTSIRG----ALGTLHQLGVVIGILMAqifgteSVMGNASLWPLLLAFTLLPAVLQCVLLplcpespryllinc 217
Cdd:cd17329   112 MIADVTTPENRTrafsLLYWAINLGVAIGPLLG------GLLLLYSFRLLFLAAAVLFLLAALVLL-------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 218 neeskarsILVKLRGTDEVSEDMQEMKEEGQQMMREKKVTIPELfrspmyrqpIFVAIMLqLSQQLSginavFYYSTRIF 297
Cdd:cd17329   172 --------FLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLL---------ASFLISL-IYFQLE-----STLPVYVV 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175 298 ERAGVSQPVYATIGAgvVNTAFTVVSLFVV----ERVGRRPLHLTGLMGMAVSAVFLTVAMALldqlkwmsyvsiVAIFS 373
Cdd:cd17329   229 EILGLGESLLGLLLA--LNALLIVLLQFPVarlvERFRLRKILMIGILLFAIGFAVLAFANTL------------AVLIL 294

                  ....*...
gi 1678704175 374 FVAFFEIG 381
Cdd:cd17329   295 AMIVLTLG 302
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
62-158 5.87e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 38.94  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  62 ALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVaaaFMGLSKLASSFEMLIIGRFIVGL-YCGLCTGFVP 140
Cdd:cd17447    35 GLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLV---FGLASAFSVSYVMFAITRTLTGFaLTGFSIISMV 111
                          90       100
                  ....*....|....*....|
gi 1678704175 141 LYVE--EISPTSIRGALGTL 158
Cdd:cd17447   112 LCVEwvDIEHRTVAGVLISL 131
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
65-207 6.00e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.06  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  65 SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLAFVAAAfmgLSKLASSFEMLIIGRFIVGLYCGLCTGFVPLYVE 144
Cdd:cd17372    37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGF---LSAFAPNYMWLIILRCLVGLGLGGGPQLASWYLE 113
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1678704175 145 EIsPTSIRGALGTLHQLGVVIGILMaqIFGTESVMGNASLWPLLLAFTLLPAVLQCVLLPLCP 207
Cdd:cd17372   114 FL-PAKSRGTWMVLFSVFWTVGTIF--EASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTP 173
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
62-196 6.10e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  62 ALWSLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLmanVLAFVAAAFMGLSKLASSFEMLIIGRFIVGLycGLCTGFVPL 141
Cdd:cd06173   244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL---IGALLLGLALLVLGLSPSLWLLLAALFLLGL--AGGLFNVPL 318
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678704175 142 --YVEEISPTSIRGALGTLH--------QLGVVIGILMAQIFGTESVMGNASLWPLLLAFTLLPA 196
Cdd:cd06173   319 ntLLQLRVPDELRGRVFSVYnalnsgamPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
82-205 6.87e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 38.71  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  82 VGLFVNRFGRKNSMLMANVLAFVAAAFMGlskLASSFEMLIIGRFIVGLYCGLCTGFVPLYVEEISPTSIRGALGTLHQL 161
Cdd:cd17503    51 SGWLADRFGTRRLFLTALALFTLGSLLCG---LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGL 127
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1678704175 162 GVVIGILMAQIFG---TEsvmgNASlWPLLLAFTLLPAVLQCVLLPL 205
Cdd:cd17503   128 VILLAPAIGPTLGgwlTD----NLS-WRWIFYINLPIGILALLLAPL 169
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
49-134 7.52e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 38.55  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678704175  49 SRFSEPISQTTLTALW--SLSVAIFSVGGMFGSFSVGLFVNRFGRKNSMLMANVLafVAAAFMGLSKLASSFEMLIIGRF 126
Cdd:cd17314    23 SLFYQPWQDAFGYSSSqiATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIM--VLAGYTYLSYVFNSFPLSYACFV 100

                  ....*...
gi 1678704175 127 IVGLYCGL 134
Cdd:cd17314   101 FIGAGTGI 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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