|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
38-470 |
3.21e-162 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 465.89 E-value: 3.21e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 38 EAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTGFAFMVGLSGALETLCGQGFGAKLYRMLG 117
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 118 IYLQASSIISFLASIIVSVVWFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVI 197
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 198 PVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAAMVCLE 277
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 278 YWAFEILVFMAGVMPkAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVD 357
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 358 LALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGVLAFKL 437
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|...
gi 1632181990 438 KLYAKGLWIGLICGLSCQTVLLLVVTLRTKWTQ 470
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDK 432
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
38-461 |
1.02e-54 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 188.86 E-value: 1.02e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 38 EAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANS-WATVtgFAFMVGLSGALETLCGQGFGAKLYRML 116
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSlWFPV--FTFGMGLLLAVTPLVAQAHGAGDRRRI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 117 GIYLQASSIISFLASIIVSVVWFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYgFLHNILR-FLQTQSVVIPLVYFS 195
Cdd:cd13131 79 RRAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPA-LLFQVLRsFLDALGRTRPAMVIT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 196 VIPVVLHVGIAYGLVH----WTGLGYVGAPVAASISIWISMLMLATYVLCAKKFE--HTWEGFTLESFHYVLPNLKLALP 269
Cdd:cd13131 158 LLALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRryRLFARFWRPDWARLKELLRLGLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 270 SAAMVCLEYWAFEILVFMAGVMpkaeqNTSLIA---ICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTL 346
Cdd:cd13131 238 IGLTIFFEVSLFAAVALLMGRL-----GTTVLAahqIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 347 KLSILLALIVDLALAFGHNLWAGAFSDSSVIIKLFASmtpLLLISIL---ADSVQGVLSGVARGCGWQHLAVYVNLGTFY 423
Cdd:cd13131 313 GLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAAS---LLVFAALfqlFDGIQVVAAGALRGYKDTRVPFLLALISYW 389
|
410 420 430
....*....|....*....|....*....|....*...
gi 1632181990 424 LVGMTIAGVLAFKLKLYAKGLWIGLICGLSCQTVLLLV 461
Cdd:cd13131 390 GIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
48-389 |
3.69e-54 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 184.76 E-value: 3.69e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 48 PMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSwATVTGFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSIIS 127
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSS-VFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 128 FLASIIVSVVWFYTEPILILIHQ-DPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLHVGIA 206
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 207 YGLVH--WTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAAMVCLEYWAFEIL 284
Cdd:TIGR00797 160 YILIFgkFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 285 VFMAGvmPKAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVDLALAFGH 364
Cdd:TIGR00797 240 ALLVA--RLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 1632181990 365 NLWAGAFSDSSVIIKLFASMTPLLL 389
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
45-461 |
9.88e-49 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 172.64 E-value: 9.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 45 FSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASS 124
Cdd:COG0534 13 LALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLGQAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 125 IISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLHV 203
Cdd:COG0534 92 LLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 204 GIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAAMVCLEYWAFEI 283
Cdd:COG0534 172 VLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 284 LVFMAGVMPKAEQNTSliAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVDLALAFG 363
Cdd:COG0534 252 LNALVARLGTAAVAAY--GIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLF 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 364 HNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGVLAFkLKLYAKG 443
Cdd:COG0534 330 PEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGLGLTG 408
|
410
....*....|....*...
gi 1632181990 444 LWIGLICGLSCQTVLLLV 461
Cdd:COG0534 409 VWLALPIGEVLRALLLLL 426
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
46-469 |
6.14e-43 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 157.29 E-value: 6.14e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSI 125
Cdd:cd13137 7 AWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRALGQSLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 126 ISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQ-SVVIPL---VYFSVIPVV 200
Cdd:cd13137 86 LALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAgDTKTPMyimIIVNVLNIV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 201 LHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAAMVCLeyWA 280
Cdd:cd13137 166 LDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQLL--RS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 281 FEILVFMAGVMPKAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVDLAL 360
Cdd:cd13137 244 LGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 361 AFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGVLAFKLKLY 440
Cdd:cd13137 324 FIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLG 403
|
410 420
....*....|....*....|....*....
gi 1632181990 441 AKGLWIGLICGLSCQTVLLLVVTLRTKWT 469
Cdd:cd13137 404 LTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-468 |
4.66e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 135.73 E-value: 4.66e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWAtVTGFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSI 125
Cdd:cd13133 11 ALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLY-FAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 126 ISFLASIIVSVVWFYTEPILI-LIHQDPQISKYAALYMKFLIPGLFAYgFLHNILR-FLQTQSVVIPLVYFSVIPVVLHV 203
Cdd:cd13133 90 FSLLLAPLLALLSALAAPLLFlLLGHSPEVQALEVEYFRIRILGAPFS-LLGAALRaFFSGIGRTRVVMVANLVMVVVNI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 204 GIAYGLV--HW--TGLGYVGAPVAASISIWISMLMLATYVLCAKKFE--HTWEGFTLEsFHYVLPNLKLALPSAAMVCLE 277
Cdd:cd13133 169 VLDYALIfgKLgfPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRrfGLRRAWRFD-RELLRRILRLGLPSGLQFFLD 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 278 YWAFEILVFMAGVMPKAEQNTSLIAIcvNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVD 357
Cdd:cd13133 248 VGAFTVFFLLIGRLGTTELAATNIVF--SINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 358 LALAFGHNLWAGAFS---DSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVgMTIAGVLA 434
Cdd:cd13133 326 ILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLY-LLPPAYLL 404
|
410 420 430
....*....|....*....|....*....|....
gi 1632181990 435 FKLKLYAKGLWIGLICGLSCQTVLLLVVTLRTKW 468
Cdd:cd13133 405 VVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
37-470 |
7.96e-33 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 129.93 E-value: 7.96e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 37 EEAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANS-WATVtgFAFMVGLSGALETLCGQGFGAKLYRM 115
Cdd:PRK01766 9 SEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiWLPV--ILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 116 LGIYLQASSIISFLASIIVSVVWFYTEPILILIHQ-DPQISKYAALYMKFLIPGLFAYgFLHNILRFL-----QTQ-SVV 188
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAY-LLYQVLRSFidglgKTKpTMV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 189 IPLVYFsVIPVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEH--TWEGFTLESFHYVLPNLKL 266
Cdd:PRK01766 166 IGFLGL-LINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDfrLFKGLYKPDWAVIKRLLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 267 ALPSAAMVCleywaFEILVFMAGVMPKAEQNTSLIA---ICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMA 343
Cdd:PRK01766 245 GLPIGLAIF-----FEVSLFAVVTLLVSPLGTVTVAahqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 344 VTLKLSILLALIVDLALAFGHNLWAGAFSDSSVIIKLFASmtpLLLISI---LADSVQGVLSGVARGCGWQHLAVYVNLG 420
Cdd:PRK01766 320 IGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASH---LLLFAAlfqFSDAIQVIGSGALRGYKDTRVIFFITFI 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1632181990 421 TFYLVGMTIAGVLAFKLKLYAKGLWIGLICGLSCQTVLLLvvtLRTKWTQ 470
Cdd:PRK01766 397 AYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLL---LRLRKLQ 443
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
46-464 |
4.76e-28 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 115.50 E-value: 4.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSwATVTGFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSI 125
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFP-LIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 126 ISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLHVG 204
Cdd:cd12082 80 LAILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 205 IAYGLVH---WTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAAMVCLEYWAF 281
Cdd:cd12082 160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 282 EILVFMAGVMPKAEQnTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVDLALA 361
Cdd:cd12082 240 LIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 362 FGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLgTFYLVGMTIAGVLAFKLKLYA 441
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSL-LSYWVVRLPLAYVLAYLGLGL 397
|
410 420
....*....|....*....|...
gi 1632181990 442 KGLWIGLICGLSCQTVLLLVVTL 464
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFFR 420
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
48-207 |
2.34e-27 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 107.27 E-value: 2.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 48 PMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSIIS 127
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 128 FLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLHVGIA 206
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
.
gi 1632181990 207 Y 207
Cdd:pfam01554 160 Y 160
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-450 |
1.11e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 106.05 E-value: 1.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANswaTVTGFAFMV--GLSGALETLCGQGFGAKLYRMLGIYLQAS 123
Cdd:cd13134 9 AWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVAN---QILFLLILIfsFISTGTSILIAQYLGAKDKKKARQIAGVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 124 SIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLH 202
Cdd:cd13134 86 LLFNLLLGLVFSLLlLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 203 VGIAYGLVH----WTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAamvcLEY 278
Cdd:cd13134 166 IVGNYLLIFgwfgLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSA----GEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 279 --WAFEILVFMAGVMPKAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIV 356
Cdd:cd13134 242 lsYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 357 DLALAFGHNLWAGAFSDSSVIIKLfasMTPLLLISIL---ADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGVL 433
Cdd:cd13134 322 ALLLALFREPILGLFTDDPEIIAL---GKTLLLISILlepGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLL 398
|
410
....*....|....*..
gi 1632181990 434 AFKLKLYAKGLWIGLIC 450
Cdd:cd13134 399 GIVLGLGLLGVWIAFAA 415
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
43-468 |
3.99e-23 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 101.38 E-value: 3.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 43 VLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTGFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQA 122
Cdd:cd13138 6 LLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 123 SSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMK---FLIPGLFAYGFLHNILRFL-QTqsvVIPLvYFSVI 197
Cdd:cd13138 86 LLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLRicfLGIPFIFGYNAYSAILRGLgDS---KTPL-YFVII 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 198 PVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLmLATYVLCAKKFEHtweGFTLESFHY----VLPNLKLALPSAAM 273
Cdd:cd13138 162 ACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVL-LALYYLRKKKLPF---KLSLKDFRFdkeiLKEILKIGLPSALQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 274 VCLEYWAFEILVFMAGVMpkAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLA 353
Cdd:cd13138 238 QSLVSISFLIINSIVNSY--GVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 354 LIVDLALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGVL 433
Cdd:cd13138 316 LIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLL 395
|
410 420 430
....*....|....*....|....*....|....*
gi 1632181990 434 AFKLKLYAKGLWIGLICGLSCQTVLLLVVTLRTKW 468
Cdd:cd13138 396 SRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
269-422 |
3.58e-19 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 84.54 E-value: 3.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 269 PSAAMVCLEYWAFEILVFMAGVMPKAEqnTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKL 348
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVA--LAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1632181990 349 SILLALIVDLALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTF 422
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL 152
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-449 |
9.13e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 88.40 E-value: 9.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLanSWATV-TGFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASS 124
Cdd:cd13142 17 AWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSI--SWPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 125 IISFLASIIVSVVWFY-TEPILI-LIHQDPQISKYAALYMKFLIPGL-FAYGFL--HNILRFL-QTQSVVIPLVYFSVIP 198
Cdd:cd13142 95 SFVIILSLILAVLGYIlSRPLLLlLIGAPEEVYPLALAYLRIIFLGLpFMFIFFvfNSLLRGIgDTKTPMKIMFGSVLLN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 199 VVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLmLATYVLCAKK--FEHTWEGFTLEsFHYVLPNLKLALPSAAMVCL 276
Cdd:cd13142 175 VILDPLLIFGIGPFPGLGVAGAALATVISRGIAAV-IGLYLLFKGRvgLKISLRDLKPD-WEWLKKIFRIGLPSSIEQSA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 277 EYWAFEILVFMAGVMPkaeqnTSLIA---ICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKL-SILL 352
Cdd:cd13142 253 RALGFTVMTALVAGFG-----TVVVAaygIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLiFLIL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 353 ALIVDLALAFGHNLwAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGV 432
Cdd:cd13142 328 VIGGVLAFLFAEPI-VRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYL 406
|
410
....*....|....*..
gi 1632181990 433 LAFKLKLYAKGLWIGLI 449
Cdd:cd13142 407 LAYVLGLGVTGIWIAMA 423
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-449 |
3.69e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 83.50 E-value: 3.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANS-WATVTGFAFMVglSGALETLCGQGFGAKLYRMLGIYLQASS 124
Cdd:cd13135 7 AIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTpFNTITGFLGSI--SIGFTILGSQSVGAKDIKRINDYAISSI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 125 IISFLASIIVSVVWFYT-EPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLHV 203
Cdd:cd13135 85 VYNSIIGVILFLLWLFGaRIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 204 GIAYGLV--HW--TGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHY--VLPNLKLALPSAAMVCLe 277
Cdd:cd13135 165 ILDYVLIfgNFgfPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIrpYKFTIKLGLPLGGEEFL- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 278 yWAFEILVFMAGVMPKAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVD 357
Cdd:cd13135 244 -WNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 358 LALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNL-GTFYLVGMTIAGVLAFK 436
Cdd:cd13135 323 IVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIiGTIIVVSVALLLIFVFK 402
|
410
....*....|...
gi 1632181990 437 LKLYakGLWIGLI 449
Cdd:cd13135 403 LGLA--GVYITLF 413
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
43-403 |
1.32e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 81.79 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 43 VLFSLPMILTNVCYYMIPLISVMFAGHL-GELQLAGATLANSWAT-VTGFAFMVGLSGAleTLCGQGFGAKLYRMLGIYL 120
Cdd:cd13143 7 LKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 121 QASSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPV 199
Cdd:cd13143 85 STALLLSLILGLLLTILgLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 200 VLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSAAMvclEYW 279
Cdd:cd13143 165 VLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLM---QLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 280 AFEILVFMAGVMPKAEQNTSL--IAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVD 357
Cdd:cd13143 242 SSVVTIVLNLTLLGYGGDIGVaaFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1632181990 358 LALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSG 403
Cdd:cd13143 322 LILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSG 367
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
48-481 |
2.14e-15 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 78.25 E-value: 2.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 48 PMILTNVCYYMIPLISVMFAGHLGELQLAGATL-ANSWATVTgfAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSII 126
Cdd:PRK00187 18 PLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVS--IFCVGVIAAVGTLVAIRHGAGDIEGATRLAQAGLWL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 127 SFLASIIVSVVWFYTEPILILIHQDPQISKYAALYMK---FLIPGLFAYGFLHNilrFLQTQSVVIPLVYFSVIPVVLHV 203
Cdd:PRK00187 96 AWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLSFMALRG---FTSALGRAGPVMVISLAGAVANL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 204 GIAYGLVH-WTGLGYVGAPVAASISIWISMLM---LATYVLCAKKFEH--TWEGFTLESFHYVLPNLKLALPSAAMVCLE 277
Cdd:PRK00187 173 LLNYALIEgWFGLPKLGLMGIGLVTALVSNGMalaLALYIRRHPAYAAypLRKGLSRPSRAALRELWRLGLPIGGTYAVE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 278 YWAFEILVFMAGVMPKAEQNTSLIAIcvNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVD 357
Cdd:PRK00187 253 VGLFTFAALCMGALGSTQLAAHQIAL--QIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 358 LALAFGHNLWAGAFSD-----SSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGMTIAGV 432
Cdd:PRK00187 331 GLFWLLPEAIIGLFLDrndpaFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWL 410
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1632181990 433 LAFKLKLYAKGLWIGLICGLSCQTVLLlvvTLRTKWTQLDLPRNADAVL 481
Cdd:PRK00187 411 LAFTLGWGAVGVWWGLALGLACAAVAL---TLAFEWKTARLLRKARASE 456
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
43-468 |
3.17e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 71.49 E-value: 3.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 43 VLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQA 122
Cdd:cd13139 17 FLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAAVQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 123 SSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFA--YGFLHN-ILRFLQTQSVVIPLVYFS-VI 197
Cdd:cd13139 96 AILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFimLLFLINgIFRGAGDAAIAMRSLWLAnGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 198 PVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLAtYVLCAKKFEHTwegFTLESFHYVLPNLKLALPSAAMVCLE 277
Cdd:cd13139 176 NIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQL-YHLFKGKGRIQ---IRRRHLKLDWAIIKKIIKIAVGGILQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 278 Y------WafeilVFMAGVMpkAEQNTSLIA---ICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKL 348
Cdd:cd13139 252 FliasssW-----IFLVRII--AEFGSTALAgytIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKY 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 349 SILLALIVDLA-LAFGHNLwAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQHLAVYVNLGTFYLVGM 427
Cdd:cd13139 325 NMVFLGIVSLVfFLFAEPL-VSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQI 403
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1632181990 428 TIAGVLAFKLKLYAKGLWIGLICGLSCQTVLLLVVTLRTKW 468
Cdd:cd13139 404 PLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
29-238 |
1.85e-12 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 69.02 E-value: 1.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 29 WWNKVLDVEEAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGF 108
Cdd:COG0534 218 LRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 109 GAKLYRMLGIYLQASSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQ-TQS 186
Cdd:COG0534 297 GAGDYDRARRAARLALLLALGIGLLLALLlFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRgAGD 376
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1632181990 187 VVIPLVYFSVIPVVLHVGIAYGLVHWtGLGYVGAPVAASISIWISMLMLATY 238
Cdd:COG0534 377 TRFPMIISLLRLWLVRLPLAYLLAFL-GLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-377 |
6.16e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 64.08 E-value: 6.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGelqlagatlANSWATVTGFAFMVGLSGAL--------ETLCGQGFGAKLYRMLG 117
Cdd:cd13140 11 ALPIMGTSFIQMAYNLTDMFWVGRLG---------SDAVAAVGTAGFFVWLAYALallskigaQVKVSQSIGAKDEKEAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 118 IYLQASSIISFLASIIVS-VVWFYTEPILILIH-QDPQISKYAALYMKFLIPGLFAYgFLHNIL-RFLQTQSVVIPLVYF 194
Cdd:cd13140 82 KYARNALQLNLLLGILYGlLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFS-FLNPVFtGIFNALGDSKTPFII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 195 SVIPVVLHVgIA-----YGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALP 269
Cdd:cd13140 161 NAIGLVLNI-ILdplliFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 270 SAAMVCLeyWAFeILVFMAGVMpkAEQNTSLIA---ICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTL 346
Cdd:cd13140 240 VALQSIL--FAL-ISMILARII--ASFGPVAIAaqkVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTAL 314
|
330 340 350
....*....|....*....|....*....|..
gi 1632181990 347 KLSILLALIVDLAL-AFGHNLWAGAFSDSSVI 377
Cdd:cd13140 315 KIASAIGLFATLLLfFFGEPLFSLFIPDPETI 346
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
45-460 |
1.42e-09 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 59.88 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 45 FSLPMILTNVCYYMIPLISVMFAGHLGEL-QLAGATLAnswATVTGFAFMVG--LSGALETLCGQGFGAKLYRMLGIYLQ 121
Cdd:cd13136 8 LALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALG---TTIFNTLFWLFgfLRMGTTGLVAQALGAGDREEAIALLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 122 ASSIISFLASIIVSVVWF-YTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILR-FLQTQSVVIPLvYFSVIPV 199
Cdd:cd13136 85 RALLLALAIGLLLILLQSpLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGwFRGLQDTRTPL-ILQIVGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 200 VLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLAtyVLCAKKFEHTWEGFTLESFH------YVLPNLKLALPSAAM 273
Cdd:cd13136 164 VVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGL--WLLRRRVRLLGKSLSRRLPSkaalkrLFKLNRDIFIRTLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 274 VcleywafeiLVFMAGVMPKAEQNTSLIA---ICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSI 350
Cdd:cd13136 242 L---------AAFLFFTALAARLGDVILAanqILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 351 LLALIVDLALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCGWQH---LAVYVNLGTFYLVGM 427
Cdd:cd13136 313 GLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRylrNSMLVSLAVFLPLLF 392
|
410 420 430
....*....|....*....|....*....|...
gi 1632181990 428 TIAGVLAFklklyaKGLWIGLICGLSCQTVLLL 460
Cdd:cd13136 393 LLVPLWGN------HGLWLALILFMLLRGLTLA 419
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
58-379 |
7.79e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 57.61 E-value: 7.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 58 MIPLISVMFAGHLGELQLAGATLANSwATVTGFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSIISFLASIIVSVV 137
Cdd:cd13145 27 MFNVVDTFFAGKISTEALAALSLSFP-IFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 138 -WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAY---GFLHNILRFL-QTQSVVIPLVYFSVIPVVLHVGIAYGLVHW 212
Cdd:cd13145 106 gLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFllnFGLNGILNAQgDTKSYRNFLIIGFFLNIILDPLFIFGGGGI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 213 TGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHTWEGFTLESFHYVLPNLKLALPSA-AMVCLEYWAFEILVFMAGVM 291
Cdd:cd13145 186 PAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASlNMMTIGLGIFVITYFVGQFG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 292 PKAeqnTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILLALIVDLALAFGHNLWAGAF 371
Cdd:cd13145 266 DEA---VAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLF 342
|
....*...
gi 1632181990 372 SDSSVIIK 379
Cdd:cd13145 343 TNDPAVIA 350
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-383 |
3.61e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 55.39 E-value: 3.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAgatlANSWATVTGFAFM---VGLSGALETLCGQGFGAKLYRMLGIYLQA 122
Cdd:cd13149 15 TLPMIFGILAMLIFNLTDTFFVGKLGTKELA----AISFTFPVVLFLNsltIGLGIGASAVISRAIGAGDRNKAKRLATD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 123 SSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFL---HNILRFL-QTQSVVIPLVYFSVI 197
Cdd:cd13149 91 SLILSLLLSVIVSLLgLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPmvgNAIIRATgDTKRPSLVMLGAALV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 198 PVVLHVGIAYGLVHWTGLGYVGAPVAASISiwisMLMLATYVLCAKKFEHTWEGFTLESFHYVLPN----LKLALPSA-A 272
Cdd:cd13149 171 NVILDPILIFGFGPIPGMGIAGAAIATVIS----RALGLGAALYFLHYHHRLIDFSEPSLKALFRSwkdiLSIGIPAAlS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 273 MVCLEYWAFEILVFMAGVMPKAeqnTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKLSILL 352
Cdd:cd13149 247 NILTPLSAAFITALVATYGPAA---VAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIY 323
|
330 340 350
....*....|....*....|....*....|.
gi 1632181990 353 ALIVDLALAFGHNLWAGAFSDSSVIIKLFAS 383
Cdd:cd13149 324 GAILGIVLALFAGWLASLFSAEPEVIELITL 354
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
34-233 |
1.01e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 50.97 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 34 LDVEEAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSwatVTGFAFM--VGLSGALETLCGQGFGAK 111
Cdd:cd13137 220 LDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLR---IESLAFMpgFGFSMAASTLVGQNLGAG 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 112 LYRMLGIYLQASSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQ----TQs 186
Cdd:cd13137 297 DPDEARRYGKRALRLGVLFMGLLGLLlFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRgagdTR- 375
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1632181990 187 vvIPLVYFSVIPVVLHVGIAYGLVHWTGLGYVGapvaasisIWISML 233
Cdd:cd13137 376 --PPLIINLISMWLVRLPLAYLLGFVLGLGLTG--------IWLAMF 412
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
45-234 |
3.22e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 49.42 E-value: 3.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 45 FSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASS 124
Cdd:cd13134 233 IGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFV-FLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 125 IISFLASIIVSV-VWFYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPV-VLH 202
Cdd:cd13134 312 KIGLLVSLAVALlLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMwGIS 391
|
170 180 190
....*....|....*....|....*....|..
gi 1632181990 203 VGIAYGLVHWTGLGYVGapvaasisIWISMLM 234
Cdd:cd13134 392 VPLAYLLGIVLGLGLLG--------VWIAFAA 415
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-409 |
1.66e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 47.23 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTgFAFMVGLSGALETLCGQGFGAKLYRMLgiylQASSI 125
Cdd:cd13144 14 SIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEA----NKAAN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 126 ISFLASIIVSVVW-----FYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYF----SV 196
Cdd:cd13144 89 NGLLLALLSYLLFlllglFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAqligAI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 197 IPVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLmLATYVLCAKKFEHTwegFTLESFHYVLPNLK----LALPSAA 272
Cdd:cd13144 169 INIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMF-LAFFFLLRKNKDVQ---PDLRLFRPSLRIIKeiyaVGLPSII 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 273 MVCLeywafeILVFMAGV----MPKAEQNTSLIAICVNTESIAYMITYGLSAAASTRVSNELGAGNPEKAKNAMAVTLKL 348
Cdd:cd13144 245 MQAI------SSVMVFGLnkilAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1632181990 349 SILLALIVDLALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARGCG 409
Cdd:cd13144 319 AVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALG 379
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
94-240 |
5.18e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 45.67 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 94 VGLSGALETLCGQGFGAKLY-RMLGIYLQASSIISFLASIIVSVVWFYTEPILILIHQDPQISKYAALYMKFLIPGLFAY 172
Cdd:cd13145 287 IGLNTAVLSIAGQNFGAKKYdRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAY 366
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1632181990 173 GFLHNILRFLQTQSVVIPLVYFSVI-PVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVL 240
Cdd:cd13145 367 VVLFISVSVLQGLKRPIFALWIGLYrQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTR 435
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-245 |
1.41e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 44.23 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSwATVTGFAFMVGLSGALETLCGQGFGAKLYRMLG-IYLQASS 124
Cdd:cd13141 17 ALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGN-VMFFVMALTQVLNVGTAALVSHAVGRKDQGEANaVFNQSLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 125 IISFLASIIVSVVWFYTEPILILIHQDPQISKYAALYMKFLIPGL---FAYGFLHNILRflqTQSVVIPLVYFSVIPVVL 201
Cdd:cd13141 96 LAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLalqFILTVLGAALR---GTGIVKPFMVIQILAVLL 172
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1632181990 202 HVGIA----YGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKF 245
Cdd:cd13141 173 NIILApiliTGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKY 220
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
90-451 |
1.92e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 43.54 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 90 FAFMVGLSGALETLCGQGFGAKLYRMLGIYLQASSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIPG 168
Cdd:cd13146 60 LALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 169 LFAYGFLHNILRFLQTQSVVIPLVYFSVIPVVLHVGIAYGLVHWTGLGYVGAPVAASISIWISMLMLATYVLCAKKFEHT 248
Cdd:cd13146 140 VPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTI 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 249 WEGFTLESFHYVLPNLKLALPSAAMVCLEYWAFEIL-VFMAGVMPKAEQNTSLiaiCVNTESIAYMITYGLSAAASTRVS 327
Cdd:cd13146 220 HIKLSNISSSVIVEILRVGLPQMLLQLISSISFLIYnRIIIDIDPVAMTAFTL---VGRLDQFILIPIFAISSALLTIAG 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 328 NELGAGNPEKAKNAMAVTLKLSILLALIVDLALAFGHNLWAGAFSDSSVIIKLFASMTPLLLISILADSVQGVLSGVARG 407
Cdd:cd13146 297 QNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQA 376
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1632181990 408 CGWQHLAVYVNLGTFYLVGMTIAGVLAFKLKLYAKGLWIGLICG 451
Cdd:cd13146 377 IGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSA 420
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
30-167 |
4.46e-04 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 42.55 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 30 WNKVLDVEEAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSWATVTGFaFMVGLSGALETLCGQGFG 109
Cdd:cd13136 215 SRRLPSKAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSY-FLDGFAYAAEALVGRALG 293
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1632181990 110 AKLYRMLGIYLQASSIISFLASIIVSVV-WFYTEPILILIHQDPQISKYAALYMKFLIP 167
Cdd:cd13136 294 AGDRKAARRVARRLLQWGLGLGVLLALLfFLGGEPIIRLFTDDPAVLALAATYLPWLAL 352
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
126-289 |
4.91e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 42.44 E-value: 4.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 126 ISFLASIIVSVV-WFYTEPILILIHQ----DPQISKYAALYMKFLIPGLFAYGFLHNILRFLQTQSVVIPLVYFSVIPVV 200
Cdd:COG0728 308 LVLLLTLPAAVGlIVLAEPIVRLLFErgafTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVV 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 201 LHVGIAYGLVHWtgLGYVGAPVAASISIWISMLMLatYVLCAKKFEHTWEGFTLESFhyvlpnLKLALPSAAMVCLEYWA 280
Cdd:COG0728 388 VNIVLNLLLVPP--LGHAGLALATSLSALVNALLL--LVLLRRRLGGLPLRGILRTL------LKLLLASLVMGAVLWLL 457
|
....*....
gi 1632181990 281 FEILVFMAG 289
Cdd:COG0728 458 LRLLGDWLG 466
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
46-166 |
1.50e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 40.69 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 46 SLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANswaTVTGFAFMV--GLSGALETLCGQGFGAKLYRMLGIYLQAS 123
Cdd:TIGR00797 222 GLPIAFRVILESLSFALLALLVARLGSIALAAHQIAL---NVESLLFMPafGFGIAVSILVGQALGAGDPKRAKEVARVA 298
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1632181990 124 SIISFLASIIVS-VVWFYTEPILILIHQDPQISKYAALYMKFLI 166
Cdd:TIGR00797 299 LKLSLLLGLVLAiILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
40-230 |
4.92e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 39.20 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 40 KNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLANSwatVTGFAFMV--GLSGALETLCGQGFGAK----LY 113
Cdd:cd13135 228 KFTIKLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFG---IENIVLMPmyGYSSAALTLVGESIGKKdlkeAL 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 114 RMLGIYLQASSIISFLASIIVSVvwfYTEPILILIHQDPQISKYAALYMKFLIPGLFAYGfLHNILRF-LQTQSVVIPLV 192
Cdd:cd13135 305 RIGNICLGLGLLIYIAAAIVFLA---FPYKILSLFTNDPELINYSIPYLIFIIIILFFKS-INIVYGFaIRAIGDTKWML 380
|
170 180 190
....*....|....*....|....*....|....*...
gi 1632181990 193 YFSVIPVVLHVGIAYGLVHWTGLGYVGAPVAASISIWI 230
Cdd:cd13135 381 YTQIIGTIIVVSVALLLIFVFKLGLAGVYITLFIDEII 418
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-165 |
5.80e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 39.05 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 32 KVLDVEEAKNQVLFSLPMILTNVCYYMIPLISVMFAGHLGELQLAGATLAN-----SWATVTGFafmvglSGALETLCGQ 106
Cdd:cd13140 223 KRPDRKYIKEILKLGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSqiesiSWMTAEGF------STALAAFVGQ 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1632181990 107 GFGAKLY-RMLGIYLQASSIISFLASIIVSVVWFYTEPILILIHQDPQISKYAALYMKFL 165
Cdd:cd13140 297 NYGAGKYdRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRIL 356
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