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Conserved domains on  [gi|1540502890|ref|XP_027345551|]
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arabinosyltransferase XEG113-like [Abrus precatorius]

Protein Classification

glycosyltransferase family 77 protein( domain architecture ID 10506243)

glycosyltransferase family 77 protein acts as a nucleotide-diphospho-sugar transferase, similar to Arabidopsis thaliana UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase, arabinosyltransferase, and beta-arabinofuranosyltransferase

CAZY:  GT77
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  10521532|12691742|9445404
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nucleotid_trans pfam03407
Nucleotide-diphospho-sugar transferase; Proteins in this family have been been predicted to be ...
 150-376 1.18e-54

Nucleotide-diphospho-sugar transferase; Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.


:

Pssm-ID: 367480  Cd Length: 208  Bit Score: 185.22  E-value: 1.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540502890 150 LGLSNFLVGALDTKLLEALYWKGVPVFDMGSH---FSSVDVGWGSPTFHKMGREKVVLIDSILPFGFELLMCDTDMVWLK 226
Cdd:pfam03407   1 GLLDNLLVVALDEEAYERCKELGPPICYLLSDlkdFSKKDFGFGSKTYLKMSWRRVRLLLELLKLGYNFLFTDVDVVWLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540502890 227 NPLPYLaRYPEADILTSSDQVIPTVVDDSLEIWqevsgayNIGIFHWRPTESALKLAKQWKEMLLADDKIWDQNGFNDMI 306
Cdd:pfam03407  81 NPFPLL-RYPDADVLVSSDNYDGTTADGLKNWP-------NGGFFFVRSTNATIALFKRWAESLASYPGLWDQDVFNYLL 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540502890 307 HRQLGPSvdddsglvyafdGNLKMGILPASIFcsghTYFVQAMYQ---QLRLEPYAVHTTFQYgGTEGKRHRL 376
Cdd:pfam03407 153 REGAPPL------------LGLKCRFLDTALF----GGFCQSRDEnwvKTKLKPYIVHANCCS-GTEGKLKRL 208
O-FucT super family cl28768
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
 422-471 2.29e-03

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


The actual alignment was detected with superfamily member pfam10250:

Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 39.97  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1540502890 422 NYQIKQIRTALAIASLLNRTLVMPPlWCRIDRLWYPhpgilegSMTRQPF 471
Cdd:pfam10250  12 NQQRDHICDAVAFARLLNATLVLPP-WDQLYHWRDP-------STDQIPF 53
 
Name Accession Description Interval E-value
Nucleotid_trans pfam03407
Nucleotide-diphospho-sugar transferase; Proteins in this family have been been predicted to be ...
 150-376 1.18e-54

Nucleotide-diphospho-sugar transferase; Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.


Pssm-ID: 367480  Cd Length: 208  Bit Score: 185.22  E-value: 1.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540502890 150 LGLSNFLVGALDTKLLEALYWKGVPVFDMGSH---FSSVDVGWGSPTFHKMGREKVVLIDSILPFGFELLMCDTDMVWLK 226
Cdd:pfam03407   1 GLLDNLLVVALDEEAYERCKELGPPICYLLSDlkdFSKKDFGFGSKTYLKMSWRRVRLLLELLKLGYNFLFTDVDVVWLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540502890 227 NPLPYLaRYPEADILTSSDQVIPTVVDDSLEIWqevsgayNIGIFHWRPTESALKLAKQWKEMLLADDKIWDQNGFNDMI 306
Cdd:pfam03407  81 NPFPLL-RYPDADVLVSSDNYDGTTADGLKNWP-------NGGFFFVRSTNATIALFKRWAESLASYPGLWDQDVFNYLL 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540502890 307 HRQLGPSvdddsglvyafdGNLKMGILPASIFcsghTYFVQAMYQ---QLRLEPYAVHTTFQYgGTEGKRHRL 376
Cdd:pfam03407 153 REGAPPL------------LGLKCRFLDTALF----GGFCQSRDEnwvKTKLKPYIVHANCCS-GTEGKLKRL 208
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
 422-471 2.29e-03

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 39.97  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1540502890 422 NYQIKQIRTALAIASLLNRTLVMPPlWCRIDRLWYPhpgilegSMTRQPF 471
Cdd:pfam10250  12 NQQRDHICDAVAFARLLNATLVLPP-WDQLYHWRDP-------STDQIPF 53
 
Name Accession Description Interval E-value
Nucleotid_trans pfam03407
Nucleotide-diphospho-sugar transferase; Proteins in this family have been been predicted to be ...
 150-376 1.18e-54

Nucleotide-diphospho-sugar transferase; Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.


Pssm-ID: 367480  Cd Length: 208  Bit Score: 185.22  E-value: 1.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540502890 150 LGLSNFLVGALDTKLLEALYWKGVPVFDMGSH---FSSVDVGWGSPTFHKMGREKVVLIDSILPFGFELLMCDTDMVWLK 226
Cdd:pfam03407   1 GLLDNLLVVALDEEAYERCKELGPPICYLLSDlkdFSKKDFGFGSKTYLKMSWRRVRLLLELLKLGYNFLFTDVDVVWLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540502890 227 NPLPYLaRYPEADILTSSDQVIPTVVDDSLEIWqevsgayNIGIFHWRPTESALKLAKQWKEMLLADDKIWDQNGFNDMI 306
Cdd:pfam03407  81 NPFPLL-RYPDADVLVSSDNYDGTTADGLKNWP-------NGGFFFVRSTNATIALFKRWAESLASYPGLWDQDVFNYLL 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1540502890 307 HRQLGPSvdddsglvyafdGNLKMGILPASIFcsghTYFVQAMYQ---QLRLEPYAVHTTFQYgGTEGKRHRL 376
Cdd:pfam03407 153 REGAPPL------------LGLKCRFLDTALF----GGFCQSRDEnwvKTKLKPYIVHANCCS-GTEGKLKRL 208
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
 422-471 2.29e-03

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 39.97  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1540502890 422 NYQIKQIRTALAIASLLNRTLVMPPlWCRIDRLWYPhpgilegSMTRQPF 471
Cdd:pfam10250  12 NQQRDHICDAVAFARLLNATLVLPP-WDQLYHWRDP-------STDQIPF 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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