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Conserved domains on  [gi|2148370370|ref|XP_025124290|]
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kelch domain-containing protein 4 isoform X5 [Bubalus bubalis]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 15620386)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-169 1.03e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  10 LFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSgtgPTPRSGCQMTVtPQGSIIIYGGYSKQRVRKDVDRgtqhsdmfl 89
Cdd:COG3055    75 VFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPM---PTPRGGATALL-LDGKIYVVGGWDDGGNVAWVEV--------- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  90 lkaEDGSEGkwSWTRISPSgakPTPRSGFSVAVAPNHQTLLFGGVCDKEEEESL-------------------------- 143
Cdd:COG3055   142 ---YDPATG--TWTQLAPL---PTPRDHLAAAVLPDGKILVIGGRNGSGFSNTWttlaplptaraghaaavlggkilvfg 213

                         170       180
                  ....*....|....*....|....*...
gi 2148370370 144 -EGDFLNDLHFYDPVRNRWF-AGQLKGP 169
Cdd:COG3055   214 gESGFSDEVEAYDPATNTWTaLGELPTP 241
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 248-288 9.04e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 9.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2148370370 248 PSPRSNAMLAVKHGRLYLYGGMFeaGDRQVTLSDLYCLDLH 288
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYT--GGEGQPSDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-169 1.03e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  10 LFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSgtgPTPRSGCQMTVtPQGSIIIYGGYSKQRVRKDVDRgtqhsdmfl 89
Cdd:COG3055    75 VFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPM---PTPRGGATALL-LDGKIYVVGGWDDGGNVAWVEV--------- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  90 lkaEDGSEGkwSWTRISPSgakPTPRSGFSVAVAPNHQTLLFGGVCDKEEEESL-------------------------- 143
Cdd:COG3055   142 ---YDPATG--TWTQLAPL---PTPRDHLAAAVLPDGKILVIGGRNGSGFSNTWttlaplptaraghaaavlggkilvfg 213

                         170       180
                  ....*....|....*....|....*...
gi 2148370370 144 -EGDFLNDLHFYDPVRNRWF-AGQLKGP 169
Cdd:COG3055   214 gESGFSDEVEAYDPATNTWTaLGELPTP 241
PLN02193 PLN02193
nitrile-specifier protein
 1-161 2.69e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.73  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370   1 MVAWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMTVTPQgSIIIYGGYSKQRVRKDVDr 80
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEE-NVYVFGGVSATARLKTLD- 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  81 gtqhSDMFLLKaedgsegkwSWTRISPSGAKPTPRSGFSVAVAPNHQTLLFGgvcdkeeeesLEGDFLNDLHFYDPVRNR 160
Cdd:PLN02193  298 ----SYNIVDK---------KWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYG----------FNGCEVDDVHYYDPVQDK 354


                  .
gi 2148370370 161 W 161
Cdd:PLN02193  355 W 355
Kelch_3 pfam13415
Galactose oxidase, central domain;
5-57 4.79e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.13  E-value: 4.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2148370370   5 KRQLILFGGFHESTRDYiyYNDVYAFNLDTFTWSKLspsGTGPTPRSGCQMTV 57
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 248-288 9.04e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 9.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2148370370 248 PSPRSNAMLAVKHGRLYLYGGMFeaGDRQVTLSDLYCLDLH 288
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYT--GGEGQPSDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-169 1.03e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  10 LFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSgtgPTPRSGCQMTVtPQGSIIIYGGYSKQRVRKDVDRgtqhsdmfl 89
Cdd:COG3055    75 VFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPM---PTPRGGATALL-LDGKIYVVGGWDDGGNVAWVEV--------- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  90 lkaEDGSEGkwSWTRISPSgakPTPRSGFSVAVAPNHQTLLFGGVCDKEEEESL-------------------------- 143
Cdd:COG3055   142 ---YDPATG--TWTQLAPL---PTPRDHLAAAVLPDGKILVIGGRNGSGFSNTWttlaplptaraghaaavlggkilvfg 213

                         170       180
                  ....*....|....*....|....*...
gi 2148370370 144 -EGDFLNDLHFYDPVRNRWF-AGQLKGP 169
Cdd:COG3055   214 gESGFSDEVEAYDPATNTWTaLGELPTP 241
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-296 1.16e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.01  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  10 LFGGFHESTrdyiYYNDVYAFNLDTFTWSKLSPsgtGPTPRSGCQMTVTPQGSIIIYGGYSkqrvrKDVDRGTQHSDMFL 89
Cdd:COG3055    27 VAGGLSGGS----ASNSFEVYDPATNTWSELAP---LPGPPRHHAAAVAQDGKLYVFGGFT-----GANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  90 LKAEDGsegkwSWTRISPSgakPTPRSGfSVAVAPNHQTLLFGGVCDkeeeesleGDFLNDLHFYDPVRNRWfagqlkgp 169
Cdd:COG3055    95 YDPATN-----TWTKLAPM---PTPRGG-ATALLLDGKIYVVGGWDD--------GGNVAWVEVYDPATGTW-------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370 170 kaekrrrrrgrkaepggadKQVAKGPSAQEPLEVvreVVSEDGtvvtikQVLAAPGAagqlesDDDDGSEEAGVALVEPS 249
Cdd:COG3055   150 -------------------TQLAPLPTPRDHLAA---AVLPDG------KILVIGGR------NGSGFSNTWTTLAPLPT 195

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2148370370 250 PRSNAMLAVKHGRLYLYGGmfeagdRQVTLSDLYCLDLHKMeEWTIL 296
Cdd:COG3055   196 ARAGHAAAVLGGKILVFGG------ESGFSDEVEAYDPATN-TWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 1-161 2.69e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.73  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370   1 MVAWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMTVTPQgSIIIYGGYSKQRVRKDVDr 80
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEE-NVYVFGGVSATARLKTLD- 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  81 gtqhSDMFLLKaedgsegkwSWTRISPSGAKPTPRSGFSVAVAPNHQTLLFGgvcdkeeeesLEGDFLNDLHFYDPVRNR 160
Cdd:PLN02193  298 ----SYNIVDK---------KWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYG----------FNGCEVDDVHYYDPVQDK 354


                  .
gi 2148370370 161 W 161
Cdd:PLN02193  355 W 355
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
36-161 1.42e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.47  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  36 TWSKLSPSgtgPTPRSGCQmTVTPQGSIIIYGGYSKqrvrkdvdrGTQHSDMFLLkaeDGSEGKWswtriSPSGAKPTPR 115
Cdd:COG3055     2 TWSSLPDL---PTPRSEAA-AALLDGKVYVAGGLSG---------GSASNSFEVY---DPATNTW-----SELAPLPGPP 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2148370370 116 SGFSVAVAPNHQTLLFGGVCDKEEeeslEGDFLNDLHFYDPVRNRW 161
Cdd:COG3055    61 RHHAAAVAQDGKLYVFGGFTGANP----SSTPLNDVYVYDPATNTW 102
Kelch_3 pfam13415
Galactose oxidase, central domain;
5-57 4.79e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.13  E-value: 4.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2148370370   5 KRQLILFGGFHESTRDYiyYNDVYAFNLDTFTWSKLspsGTGPTPRSGCQMTV 57
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
PLN02193 PLN02193
nitrile-specifier protein
 11-162 1.02e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 44.18  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  11 FGGfhESTRDYIYYNDVYAFNLDTFTWSkLSPSgTGPTPRSGCQ--MTVTPQGSIIIYGGyskqrvrKDVDRgtQHSDMF 88
Cdd:PLN02193  181 FGG--EFTPNQPIDKHLYVFDLETRTWS-ISPA-TGDVPHLSCLgvRMVSIGSTLYVFGG-------RDASR--QYNGFY 247

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2148370370  89 LLKAEDGsegkwSWTRISPSGAKPTPRSGFSVAvAPNHQTLLFGGVCDKEEeeslegdfLNDLHFYDPVRNRWF 162
Cdd:PLN02193  248 SFDTTTN-----EWKLLTPVEEGPTPRSFHSMA-ADEENVYVFGGVSATAR--------LKTLDSYNIVDKKWF 307
Kelch_4 pfam13418
Galactose oxidase, central domain;
114-161 1.39e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2148370370 114 PRSGFSVAVAPNHQTLLFGGvcdkeeeESLEGDFLNDLHFYDPVRNRW 161
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG-------EGEDGTLLSDLWVFDLSTNEW 41
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
7-75 2.20e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 42.84  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2148370370   7 QLILFGGFHEstrdyiYYNDVYAFNLDTFTWSKLspsGTGPTPRSGcQMTVTPQGSIIIYGGYSKQRVR 75
Cdd:COG3055   208 KILVFGGESG------FSDEVEAYDPATNTWTAL---GELPTPRHG-HAAVLTDGKVYVIGGETKPGVR 266
Kelch_4 pfam13418
Galactose oxidase, central domain;
49-108 2.41e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  49 PRSGCQMTVTPQGSIIIYGGYSKQrvrkdvdrGTQHSDMFLLKAEDGsegkwSWTRISPS 108
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGED--------GTLLSDLWVFDLSTN-----EWTRLGSL 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
5-45 2.94e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2148370370   5 KRQLILFGGFhesTRDYIYYNDVYAFNLDTFTWSKLSPSGT 45
Cdd:pfam13418  12 DDTIYLFGGE---GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
PLN02153 PLN02153
epithiospecifier protein
 1-170 6.57e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.51  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370   1 MVAWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTW---SKLSPSGtGPTPRSGCQMTvTPQGSIIIYGGYSKQRVRKD 77
Cdd:PLN02153   81 MVAVGTKLYIFGGRDEKRE----FSDFYSYDTVKNEWtflTKLDEEG-GPEARTFHSMA-SDENHVYVFGGVSKGGLMKT 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  78 VDRgtqhsdMFLLKAEDGSEGKWswTRISPSGAKPTPRSGFSVAVAPNHQTLLFGGVCD-----KEEEESlegdflNDLH 152
Cdd:PLN02153  155 PER------FRTIEAYNIADGKW--VQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSilpggKSDYES------NAVQ 220

                         170
                  ....*....|....*...
gi 2148370370 153 FYDPVRNRWFAGQLKGPK 170
Cdd:PLN02153  221 FFDPASGKWTEVETTGAK 238
PLN02153 PLN02153
epithiospecifier protein
 24-133 7.43e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 38.04  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2148370370  24 YNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMTVTpQGSIIIYGGYSKQRVRKDVDRGTQHSDMFLlkaeDGSEGKWswT 103
Cdd:PLN02153  158 FRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVV-QGKIWVVYGFATSILPGGKSDYESNAVQFF----DPASGKW--T 230

                          90       100       110
                  ....*....|....*....|....*....|
gi 2148370370 104 RISPSGAKPTPRSGFSVAVAPNHqTLLFGG 133
Cdd:PLN02153  231 EVETTGAKPSARSVFAHAVVGKY-IIIFGG 259
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 248-288 9.04e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 9.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2148370370 248 PSPRSNAMLAVKHGRLYLYGGMFeaGDRQVTLSDLYCLDLH 288
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYT--GGEGQPSDDVYVLSLP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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