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Conserved domains on  [gi|2024403389|ref|XP_025006083|]
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major facilitator superfamily domain-containing protein 10 isoform X1 [Gallus gallus]

Protein Classification

major facilitator superfamily domain-containing protein 10( domain architecture ID 13024405)

major facilitator superfamily domain-containing protein 10 (MFSD10) may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 25-427 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 568.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  25 ITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLYLSLQRG-VDWFAAMVGMPPERKYNSVLFGGLIGSMFSILQFFS 103
Cdd:cd17389     1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 104 SPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17389    81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 184 FSLGFTLGPMIGAYLAMETEK-GEVFYLRSALLALTFAAADLIFIFFLLPETLPkekrvssvttgfqaaadllspmalfr 262
Cdd:cd17389   161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 263 fsavtqgkeapsdqnlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17389   215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 343 NEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 422
Cdd:cd17389   279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358


                  ....*
gi 2024403389 423 LSATA 427
Cdd:cd17389   359 VACTV 363
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 25-427 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 568.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  25 ITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLYLSLQRG-VDWFAAMVGMPPERKYNSVLFGGLIGSMFSILQFFS 103
Cdd:cd17389     1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 104 SPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17389    81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 184 FSLGFTLGPMIGAYLAMETEK-GEVFYLRSALLALTFAAADLIFIFFLLPETLPkekrvssvttgfqaaadllspmalfr 262
Cdd:cd17389   161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 263 fsavtqgkeapsdqnlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17389   215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 343 NEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 422
Cdd:cd17389   279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358


                  ....*
gi 2024403389 423 LSATA 427
Cdd:cd17389   359 VACTV 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-419 2.25e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.68  E-value: 2.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  23 RVITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLylslqrgvdwfaamvgmpperkynsvlfgGLIGSMFSILQFF 102
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA-----------------------------GLVVTAYLLGAAL 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 103 SSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAIIADLHSPKARSKGMAMIG 181
Cdd:COG2814    61 GAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 182 VAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRvssvttgfqaaADLLSPMALF 261
Cdd:COG2814   141 AGLGLGPALGPLLGGLLADLFGWRWVFLV-----NAVLALLALLLLLRLLPESRPAARA-----------RLRGSLRELL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 262 RFSAVTqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKP 341
Cdd:COG2814   205 RRPRLL---------------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024403389 342 GNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARAL 419
Cdd:COG2814   270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
67-421 2.95e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.57  E-value: 2.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  67 GVDWFAAMVGMPPERKYN---SVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVF 143
Cdd:pfam07690   9 ALGRSLLGPALPLLLAEDlgiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 144 LLSRMVGGISKGNV-SLCTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallalTFAAA 222
Cdd:pfam07690  89 LVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI-------LAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 223 DLIFIFFLLPETLPKEKRVSSVTTGFQAAADLLSPMALFRFsavtqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTL 302
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV-------------------LWLLLALLLFGFAFFGLLTY 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 303 SFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYS 379
Cdd:pfam07690 223 LPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLG 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2024403389 380 FAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGP 421
Cdd:pfam07690 303 FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-234 5.47e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.91  E-value: 5.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT-AIIADLH 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPET 234
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLF-----LAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-240 2.33e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 56.08  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  96 FSILQFFSSPLtgavSDCLGRRPVILM-TAMGLIASYALwAASRSFGVFLLSRMVGGISKGNVS-LCTAIIADLHSPKAR 173
Cdd:PRK11102   39 FAIGQLFYGPM----ADSFGRKPVILGgTLVFALAAVAC-ALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEF 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024403389 174 SKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLRSALLALTFaaadlIFIFFLLPETLPKEKR 240
Cdd:PRK11102  114 SRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAA-----ALVFFFIPETLPKERR 175
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 25-427 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 568.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  25 ITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLYLSLQRG-VDWFAAMVGMPPERKYNSVLFGGLIGSMFSILQFFS 103
Cdd:cd17389     1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 104 SPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17389    81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 184 FSLGFTLGPMIGAYLAMETEK-GEVFYLRSALLALTFAAADLIFIFFLLPETLPkekrvssvttgfqaaadllspmalfr 262
Cdd:cd17389   161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 263 fsavtqgkeapsdqnlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17389   215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 343 NEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 422
Cdd:cd17389   279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358


                  ....*
gi 2024403389 423 LSATA 427
Cdd:cd17389   359 VACTV 363
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 28-427 1.09e-57

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 194.72  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  28 VFLALLIDLLGFALILPLFPSILDYYSQTEDglylslqrgvdwfaamvgmpperkynSVLFGGLIGSMFSILQFFSSPLT 107
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGA--------------------------SGYYVGLLQSSYSLGQFLASPLW 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 108 GAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGVAFSLG 187
Cdd:cd17330    55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 188 FTLGPMIGAYLAmetekgevfylrsallaltfaaadlififFLLPETLPkekrvssvtTGFQAAADLLSPMALFRFsavt 267
Cdd:cd17330   135 FILGPALGGFLS-----------------------------TPYGYALP---------FLVAAALALLNLVLVLFF---- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 268 qgkeapsdqnLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKP-GNEIR 346
Cdd:cd17330   173 ----------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERK 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 347 VVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSAT 426
Cdd:cd17330   243 LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322


                  .
gi 2024403389 427 A 427
Cdd:cd17330   323 L 323
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 25-426 7.21e-38

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 142.77  E-value: 7.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  25 ITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLylslqrgvdwfaamvgmpperkynsVLFGGLIGSMFSILQFFSS 104
Cdd:cd17388     1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADA-------------------------ATHYGVLLALYALMQFIFA 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 105 PLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGVAF 184
Cdd:cd17388    56 PILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAF 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 185 SLGFTLGPMIGAYLAmetekgeVFYLRS-ALLALTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQAAADLlspMALFRF 263
Cdd:cd17388   136 GLGFIAGPALGGLLG-------EISPRApFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSL---RWLTGF 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 264 SAvtqgkeapsdqnlqnLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKP-- 341
Cdd:cd17388   206 PG---------------LLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKrl 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 342 GNeirvvKRAVLLLIPA----FLLIGWAANVTLLSAGLLLYSfAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALAR 417
Cdd:cd17388   271 GE-----KRAILLGLAAdalgFLLLAFATQGWMVFPILILLA-LGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTS 344


                  ....*....
gi 2024403389 418 ALGPVLSAT 426
Cdd:cd17388   345 IIGPLLFTG 353
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 24-432 4.35e-36

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 136.97  E-value: 4.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  24 VITIVFLalliDLLGFALILPLFPSILDYYsqtedglylslqrgvdwfaamvGMPPerkynsvLFGGLIGSMFSILQFFS 103
Cdd:cd17390     1 LYLVGFL----DLFGVSMILPLLSTHIRSL----------------------GASP-------TVIGLIGSVYGALQLFS 47

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 104 SPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17390    48 SPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAA 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 184 FSLGFTLGPMIGAYLaMETEKGevFYLRSALLALTFAAADLIfIFFLLPEtlpkekrvssvttgfqaAADLLspmaLFRF 263
Cdd:cd17390   128 SSLGFILGPVVGGHL-AETDGG--FYYVALLCSAIFILNAGL-VWFLLSK-----------------LWDLL----LVRF 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 264 savtqgkeapsdqnlqnlkILGLAYFLYlflfsglEYTLSFLTHQRFQFSSMQQGKMFFFIGItMAVIQGGYARRIK--- 340
Cdd:cd17390   183 -------------------LMGFSVLLF-------RSNFSLYLEERFDLSPKTIGYLISYSGV-LGALSGFLVGRILkly 235

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 341 PGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALG 420
Cdd:cd17390   236 KNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILA 315

                         410
                  ....*....|..
gi 2024403389 421 PVLSATADEGGV 432
Cdd:cd17390   316 PLLSGLLQEFSV 327
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 28-424 4.40e-32

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 126.15  E-value: 4.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  28 VFLALLIDLLGFALILPLFPSildyysqtedglylslqrgvdwFAAMVGMpperkynSVLFGGLIGSMFSILQFFSSPLT 107
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPL----------------------YAESLGA-------SVAQIGLIVAAYALAQLLFSPPA 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 108 GAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAIIADLHSPKARSKGMAMIGVAFSL 186
Cdd:cd17325    52 GRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGL 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 187 GFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQAAADLLSpmalfrfsav 266
Cdd:cd17325   132 GFLIGPLLGGLLADALGYRAPFLV-----CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL---------- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 267 tqgkeapsdqNLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIkpgN 343
Cdd:cd17325   197 ----------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQppaGKLSDRI---G 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 344 EIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVL 423
Cdd:cd17325   264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343


                  .
gi 2024403389 424 S 424
Cdd:cd17325   344 G 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-419 2.25e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.68  E-value: 2.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  23 RVITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLylslqrgvdwfaamvgmpperkynsvlfgGLIGSMFSILQFF 102
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA-----------------------------GLVVTAYLLGAAL 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 103 SSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAIIADLHSPKARSKGMAMIG 181
Cdd:COG2814    61 GAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 182 VAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRvssvttgfqaaADLLSPMALF 261
Cdd:COG2814   141 AGLGLGPALGPLLGGLLADLFGWRWVFLV-----NAVLALLALLLLLRLLPESRPAARA-----------RLRGSLRELL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 262 RFSAVTqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKP 341
Cdd:COG2814   205 RRPRLL---------------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024403389 342 GNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARAL 419
Cdd:COG2814   270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 25-425 7.40e-25

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 105.73  E-value: 7.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  25 ITIVFLALLIDLLGFALILPLFPSILDYYSQTEdglylslqrgvdwfaAMVGMpperkynsvlfggLIGSmFSILQFFSS 104
Cdd:cd17474     1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASP---------------AQVGL-------------LITA-FTLPAAVLM 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 105 PLTGAVSDCLGRRpVILMTAMGLIASYALWAA-SRSFGVFLLSRMVGGI-SKGNVSLCTAIIADLHSPKARSKGMAMIGV 182
Cdd:cd17474    52 PVAGVLADRFGRK-KVLLPGLLLFGIGGLLCGlSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEA 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 183 AFSLGFTLGPMIGAYLAMETEKGeVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSsvttgfqaAADLLSPMALFR 262
Cdd:cd17474   131 ALGLGIAVGPLLGGLLAAISWRY-PFFL-----LAALIPVAFLAILFLLPEPKEKAKSSS--------ATKLRDLKKALR 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 263 FSAVtqgkeapsdqnlqnLKILGLAYFLYLFLFSGLEYtLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17474   197 GRGL--------------LTFLVSAFLYFFLYFAFLTY-LPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 343 -NEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGP 421
Cdd:cd17474   262 fGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP 341


                  ....
gi 2024403389 422 VLSA 425
Cdd:cd17474   342 LLFG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
67-421 2.95e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.57  E-value: 2.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  67 GVDWFAAMVGMPPERKYN---SVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVF 143
Cdd:pfam07690   9 ALGRSLLGPALPLLLAEDlgiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 144 LLSRMVGGISKGNV-SLCTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallalTFAAA 222
Cdd:pfam07690  89 LVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI-------LAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 223 DLIFIFFLLPETLPKEKRVSSVTTGFQAAADLLSPMALFRFsavtqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTL 302
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV-------------------LWLLLALLLFGFAFFGLLTY 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 303 SFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYS 379
Cdd:pfam07690 223 LPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLG 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2024403389 380 FAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGP 421
Cdd:pfam07690 303 FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 84-425 6.78e-19

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 88.43  E-value: 6.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  84 NSVLFGGLIgSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRmVGGISKGNVSLCTAI 163
Cdd:cd17331    33 DSVVFGYLQ-TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmetekgEVFYLRSALLALTFAAADLIFIFFLLPETLPKEKRVSS 243
Cdd:cd17331   111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLT------KKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 244 vttgfqaAADLLSPMALFRFSAVTQGKEAPSDQNLQNLKILGLayflylFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFF 323
Cdd:cd17331   185 -------AKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSG------LPIGMFQSMFSLVAMDFFGLTPEENGYLMSY 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 324 IGITMAVIQGGYARR-IKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQK 402
Cdd:cd17331   252 AGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDT 331

                         330       340
                  ....*....|....*....|...
gi 2024403389 403 GRVMGILRSLGALARALGPVLSA 425
Cdd:cd17331   332 GTALGLSHALFSLVRTVSPTIGG 354
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 90-425 1.55e-16

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 81.12  E-value: 1.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIADLH 168
Cdd:cd17329    38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFePASEAMIADVT 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEtekgevFYLRSALLALTFAAADLIFIFFLLPETLPKEKRVssvttgf 248
Cdd:cd17329   118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY------SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 QAAADLLSPMALFRFSAVTqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:cd17329   185 EKTEILRGYKIVLRDRAFL---------------LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLI 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 329 AVIQGGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGI 408
Cdd:cd17329   250 VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329

                         330
                  ....*....|....*..
gi 2024403389 409 LRSLGALARALGPVLSA 425
Cdd:cd17329   330 YALAWGLGRAIGPLVGG 346
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-425 4.14e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 76.70  E-value: 4.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIADLH 168
Cdd:cd06174    34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIdPAVLALIADLF 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGevfyLRSALLALTFAAADLIFIFFLLPETLPKEKRVSSVTTGF 248
Cdd:cd06174   114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG----WRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 QAAADLLSPMALFRfsavtqgkeapsdqnlqNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKM---FFFIG 325
Cdd:cd06174   190 KSVLKLLKRVLKNP-----------------GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLlslFGLAG 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 326 ITMAVIQGGYARRIKPGNEIRVVkrAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 405
Cdd:cd06174   253 ALGSLLLGLLSDRLIGRKPLLLI--GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTA 330

                         330       340
                  ....*....|....*....|
gi 2024403389 406 MGILRSLGALARALGPVLSA 425
Cdd:cd06174   331 FGLLNTFGFLGGAIGPLLAG 350
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 96-433 5.19e-15

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 76.46  E-value: 5.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  96 FSILQFFSSPLtgavSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT-AIIADLHSPKARS 174
Cdd:cd17320    47 FALGQLLYGPL----SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVArAIVRDLYSGAELA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 175 KGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQAAADL 254
Cdd:cd17320   123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF-----LALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRV 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 255 LSpMALFRFSAVTQGkeapsdqnlqnlkILGLAYFLYLFlfsgleyTLSFLTHQRFQFSSMQQGKMFFFIGITM---AVI 331
Cdd:cd17320   198 LK-NRRFLGYALALG-------------LSFAGLFAYLA-------AAPFIYIEQLGLSPAQFGLLFALNAIALilgSLL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 332 QGGYARRIKPGNEIRVVkrAVLLLIPAFLLIGWA----ANVTLLSAGLLLYSFAAAIVIP-CLSAVVSGYGsaSQKGRVM 406
Cdd:cd17320   257 NGRLVRRFGPRRLLRLG--LLLLLAAALVLLLAAllggLSLWPLVAPLFLIFFGFGLIFPnATSLALEPFP--HVAGTAS 332

                         330       340
                  ....*....|....*....|....*..
gi 2024403389 407 GILRSLGALARALGPVLSATADEGGVG 433
Cdd:cd17320   333 ALLGFLQFLIGALAGALVGLLPNGTAL 359
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-234 5.47e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.91  E-value: 5.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT-AIIADLH 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPET 234
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLF-----LAILALAAFILLAFLLPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 90-427 2.50e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.51  E-value: 2.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIADLH 168
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSSVTTGF 248
Cdd:cd17324   117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA-----IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 QAAadLLSPMALFRFsavtqgkeapsdqnlqnlkilgLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:cd17324   192 LLL--LRNPRLRLAY----------------------LITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 329 AV---IQGGYARRIKPGneiRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASqKGRV 405
Cdd:cd17324   248 VVgspLAGRLADRGGRR---ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLA 323

                         330       340
                  ....*....|....*....|..
gi 2024403389 406 MGILRSLGALARALGPVLSATA 427
Cdd:cd17324   324 SSLYLAAYNLGGALGAALGGLV 345
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 84-433 3.73e-14

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 73.76  E-value: 3.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  84 NSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVilmtamgLIASYALWAASRSFGVF-------LLSRMVGGISKGN 156
Cdd:cd17473    32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRL-------LIAGLLLYGIGGVAGLFldslyalLASRALLGIGVAG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 157 V-SLCTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmetekgeVFYLRSALLALTFAAADLIFIFFLLPETL 235
Cdd:cd17473   105 ImTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-------EIGWRAPFLVYLLALPVLILVLLFLPEPA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 236 PKEKRVSSvttgfqaaadllspmalfrfsavTQGKEAPSDQNLQNLKILGLAYFLYLFLFSGLEYtLSFLTHQRFQFSSM 315
Cdd:cd17473   178 RKSKSAAS-----------------------PGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQ-LPFLLQERGGGSAA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 316 QQGKMFFFIGITMAVIQGGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSG 395
Cdd:cd17473   234 LIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS 313

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2024403389 396 YGSASQKGRVMGILRSLGALARALGPVLSATADEGGVG 433
Cdd:cd17473   314 LVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGG 351
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 84-423 5.51e-13

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 70.53  E-value: 5.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  84 NSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSrmVGGISKGNVSLCTAI 163
Cdd:cd17387    33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VSGIFSVTFSVIFAY 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLRSallalTFAAADLIFIFFLLPETLPKEKRVSS 243
Cdd:cd17387   111 VADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVAT-----IVALLDICFILLAVPESLPEKMRPAS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 244 VTTGFQ-AAADllsPMALFRFSavtqGKEapsdqnlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF 322
Cdd:cd17387   186 WGAPISwEQAD---PFASLRKV----GKD-------KTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIA 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 323 FIGITMAVIQG--GYARRIKPGNeirvvKRAVLL-LIPAFLLIGWAANVT----LLSAGLLlySFAAAIVIPCLSAVVSG 395
Cdd:cd17387   252 VVGILSITAQTllLSILMRSIGA-----KNTILLgLGFQMLQLAWYGFGSqhwmMWAAGAV--AAMSSITFPAISALVSR 324

                         330       340
                  ....*....|....*....|....*...
gi 2024403389 396 YGSASQKGRVMGILRSLGALARALGPVL 423
Cdd:cd17387   325 YADPDQQGAVQGMITGIRGLCNGLGPAL 352
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
90-423 1.62e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAIIADLH 168
Cdd:COG2271    48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmetekgEVFYLRSallaltfaaadlIFIFFLLPETLpkekrvssvttgf 248
Cdd:COG2271   128 PPKERGRALGIFNAGGPLGGALAPPLLGWLL------AAFGWRA------------AFLILGLPGLL------------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 qaaadllspMALFRFSAvtqgkeapsdqnlqnlkiLGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:COG2271   177 ---------LALLRFWL------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 329 AVIQ--GGY-ARRIKPGNeIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 405
Cdd:COG2271   230 IVGSllGGWlSDRLGRRR-KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA 308

                         330
                  ....*....|....*...
gi 2024403389 406 MGILRSLGALARALGPVL 423
Cdd:COG2271   309 SGLVNTFGFLGGALGPLL 326
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-423 2.95e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 68.00  E-value: 2.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHS 169
Cdd:cd17489    34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 170 PKAR-SKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSSVTTGF 248
Cdd:cd17489   114 PPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-----AAVLALLALLLVFLVKDPPPVAAEEAEAGTRAF 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 QAAAD--LLSPMALFRFSAVTQGkeapsdqnlqnlkilGLAYFLYLFLFS-GLEYTLSFLThqrfqfssmqqgkmffFIG 325
Cdd:cd17489   189 RRLVEkkVLPPALILFLASIAYG---------------AISTFLPLYAAErGISNAGLFFT----------------VYA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 326 ITMAVIQGGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 405
Cdd:cd17489   238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317

                         330
                  ....*....|....*...
gi 2024403389 406 MGILRSLGALARALGPVL 423
Cdd:cd17489   318 NGTFFIFFDLGIGLGGLL 335
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 88-205 9.03e-12

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 66.46  E-value: 9.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  88 FGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGL-IASYALWAASRSFG-----VFLLSRMVGGISKGNVSLCT 161
Cdd:cd17326    37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIaIVGNILYALAEYFPsnrkyVMLVARFLIGVGAGNVAVLR 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2024403389 162 AIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKG 205
Cdd:cd17326   117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 84-427 5.83e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 64.17  E-value: 5.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  84 NSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMT---AMGLIASYALWAASRSFG---VFLLSRMVGGISKGNV 157
Cdd:cd06173    31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllRALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 158 SLCTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallaltfaAADLIFIFFLLPETLPK 237
Cdd:cd06173   111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI----------NALSFLLSALLLLFIRR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 238 EKRVSSVTTGFQAAADLLSPMALFRFSAVtqgkeapsdqnlqnLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQ 317
Cdd:cd06173   181 PPPAAPGESSSLLLRDLREGLRYLRRSPL--------------LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 318 GKMFFFIGITMAVIQGGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYG 397
Cdd:cd06173   247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326

                         330       340       350
                  ....*....|....*....|....*....|
gi 2024403389 398 SASQKGRVMGILRSLGALARALGPVLSATA 427
Cdd:cd06173   327 PDELRGRVFSVYNALNSGAMPLGALLAGLL 356
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
23-423 1.49e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 62.95  E-value: 1.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  23 RVITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLylslqrgvdwfaamvgmpperkynsvlfgGLIGSMFSILQFF 102
Cdd:COG0738     8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQA-----------------------------GLLLFAFFLGYLL 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 103 SSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGV 182
Cdd:COG0738    59 ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHA 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 183 AFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQAaadllSPMALFR 262
Cdd:COG0738   139 FFSLGALLGPLLGGLLILLGLSLSWHLP-----YLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA-----SLKSLLK 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 263 FSAvtqgkeapsdqnlqnLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAV---IQGGYARRI 339
Cdd:COG0738   209 NPR---------------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIgrfLGGFLLKRF 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 340 KPGneiRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCL-SAVVSGYGSASQKGrvMGILRSLGALARA 418
Cdd:COG0738   274 GPV---RLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfSLALDGLGKRTAAA--VSAVLIMGIVGGA 348


                  ....*
gi 2024403389 419 LGPVL 423
Cdd:COG0738   349 IGPPL 353
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 94-398 2.56e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.21  E-value: 2.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  94 SMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIADLHSPKA 172
Cdd:cd17323    41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEE 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 173 RSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLpkekrVSSVTTGFQAAa 252
Cdd:cd17323   121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF-----LAIISGFCLILIFLFLPIVL-----LLGLYVGLVYA- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 253 dllspmalfrfsavtqgkeapsdqnlqnlkilglayFLYLFLFsgleyTLSFLTHQRFQFSSMQQGKMFFFIGITMaVIQ 332
Cdd:cd17323   190 ------------------------------------ILYLFLT-----AFPYVFGEVYGFSPGEVGLMYLPIGIGA-LIG 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 333 GGYARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAA----IVIPCLSAVVSGYGS 398
Cdd:cd17323   228 SIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYphihWIVPIIGSAFFGFGL 297
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 23-305 1.90e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 58.67  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  23 RVITIVFLALLIDLLGFALILPLFPSILDYYSQTEDGLylslqrgvdwfaamvgmpperkynsvlfgGLIGSMFSILQFF 102
Cdd:COG0477    14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL-----------------------------GWIVSAYLLGRAI 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 103 SSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAIIADLHSPKARSKGMAMIG 181
Cdd:COG0477    65 GLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 182 VAFSLGFTLGPMIGAYLAmetekgEVFYLRSALLALTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQAAADLLSPMALF 261
Cdd:COG0477   145 AAIGLGLALGPLLGGLLV------AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLAL 218

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2024403389 262 RFSAVTQGKEAPSDQNLQNLKILGLAYFLYLFLFSGLEYTLSFL 305
Cdd:COG0477   219 LLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 90-199 1.63e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG--NVSLcTAIIADL 167
Cdd:cd17325   238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlvFPAT-LALLADI 316

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2024403389 168 HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLA 199
Cdd:cd17325   317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-423 1.77e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.43  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAIIADLH 168
Cdd:COG2223    43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGgSFAVGIALVSKWF 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmetekgEVFYLRSALLALTFAAADLIFIFFLLPETLPKEKRVSsvttgf 248
Cdd:COG2223   123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLI------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA------ 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 qAAADLLSPMALFRFSAVTqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:COG2223   191 -AKASLRDQLEALRDPRFW---------------LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 329 AVIQ--GGY-ARRIKPGNEIRVVkrAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 405
Cdd:COG2223   255 ALGRplGGWlSDRIGGRRVLLIV--FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV 332

                         330
                  ....*....|....*...
gi 2024403389 406 MGILRSLGALARALGPVL 423
Cdd:COG2223   333 YGLVGAAGGLGGFLGPLL 350
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-240 2.33e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 56.08  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  96 FSILQFFSSPLtgavSDCLGRRPVILM-TAMGLIASYALwAASRSFGVFLLSRMVGGISKGNVS-LCTAIIADLHSPKAR 173
Cdd:PRK11102   39 FAIGQLFYGPM----ADSFGRKPVILGgTLVFALAAVAC-ALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEF 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024403389 174 SKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLRSALLALTFaaadlIFIFFLLPETLPKEKR 240
Cdd:PRK11102  114 SRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAA-----ALVFFFIPETLPKERR 175
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 106-247 2.39e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 52.77  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 106 LTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVG--GISKGNVsLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:TIGR00710  59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQafGASAGSV-ISQALVRDIYPGEELSRIYSILMPV 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024403389 184 FSLGFTLGPMIGAYLAMETEKGEVFYLRSALLALTFAAadlifIFFLLPETLPKEKRVSSVTTG 247
Cdd:TIGR00710 138 LALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL-----IFFILPETLPYEARIQISTYF 196
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 90-199 2.54e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 52.57  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILM-TAMGLIASyALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIADL 167
Cdd:cd17502    33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIaIVIFELGS-LLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADL 111

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2024403389 168 HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLA 199
Cdd:cd17502   112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFT 143
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 89-202 3.97e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 52.24  E-value: 3.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  89 GGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVS-LCTAIIADL 167
Cdd:cd17328    36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSpIAPTIIADL 115

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024403389 168 HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMET 202
Cdd:cd17328   116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAT 150
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 108-424 4.39e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 51.83  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 108 GAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGiSKGNVSLCTAIIADLHSPKARSKGMAM----IGVA 183
Cdd:cd17472    53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALigasIGIA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 184 FSLGFTLGPMIGAYLAMEtekgEVFYLRSallalTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQAaadLLSPMALFRf 263
Cdd:cd17472   132 FAISMVLGPLLAAHLGVS----GLFLITA-----ILSLVSLLILLFFVPDPPKIVQISEKEKKKLKK---LLKNKRLLR- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 264 savtqgkeapsdqnlqnlkiLGLAYFLYLFLFSGLEYTLSFLTHQRFqFSSMQQGKMF---FFIGITMAVIQGGYARRIK 340
Cdd:cd17472   199 --------------------LDFSIFILHFVLMAFFYILPLLLTQLG-GGKGQLWKVYlpaILIGFILMVPFVIYAEKKG 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 341 PGNEIRVVkrAVLLLIPAFLLIGWAA-NVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARAL 419
Cdd:cd17472   258 KMKQVFVS--SILLIAVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFL 335


                  ....*
gi 2024403389 420 GPVLS 424
Cdd:cd17472   336 GGALG 340
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 87-423 6.95e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 51.50  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  87 LFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIAD 166
Cdd:cd17391    36 LWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIAS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 167 lHSPKARS-KGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLRSALlaltfaaadlIFIFFLLPETLPKEKrvssvt 245
Cdd:cd17391   116 -QTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGL----------LFLAFLLTLFFVKED------ 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 246 tgfqaaadllspmalfrFSAVTQGKEAPSDQNLQNLKILGLAYFLYLFLF---SGLEYTLSFLTHQRFQFSSMQQGKMFF 322
Cdd:cd17391   179 -----------------FKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFiiqLANQSIEPILTLYIRQLMGDASNLAFI 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 323 fIGITMAV------IQGGYARRI--KPGNEIRVVkraVLLLIPAFLLIGWAANVTLLSAGLL--LYSFAAAIVIPCLSAV 392
Cdd:cd17391   242 -SGLVFSAtgvsslLSAPRLGKLgdRIGHHRILL---GALLASALLYIPQAFVQTPWQLGILrfLLGLATGGLLPAINSL 317

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2024403389 393 VSGYGSASQKGRVMGILRSLGALARALGPVL 423
Cdd:cd17391   318 LAKITPKEVAGRIFGYNQSFQYLGNVAGPLL 348
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 90-433 1.05e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 50.63  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVI----LMTAMGLIASyalwAASRSFGVFLLSRMVGGISKGNVSLCTAIIA 165
Cdd:cd17478    34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLplgpLLTGLGLSLL----GFAPNYWLLLLLVALAGIGSAAFHPEGARLA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 166 DLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETekgevFYLRSALLALTFAAADLIFIFFLLPETLPKEKRVSSVT 245
Cdd:cd17478   110 SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF-----GGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKS 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 246 TGFQAAADLLSPMALfrfsavtqgkeapsdqnlqnlkILGLAYFLYLFLFSGLEYTLSFLTHqrfQFSSMQQGKM----F 321
Cdd:cd17478   185 SARSTLKGVWRALLL----------------------LLIIVFLRSWVLSSLTTFLPFYLVQ---RGYSLVFAGLllslF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 322 FFIGITMAVIQGGYARRIKPGNEIRVvkrAVLLLIPAFLLI----GWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYG 397
Cdd:cd17478   240 LFAGAIGTLIGGPLSDRFGRRRVIIA---SLLLAAPFLLLFlltpGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVG 316

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2024403389 398 SASqkGRVMGILRSLGALAralGPVLSATADEGGVG 433
Cdd:cd17478   317 LAS--GLMMGLSFGLGGIG---APVLGALADAFGLE 347
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 69-200 1.36e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 50.27  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  69 DWFAAMVGMpperkynSVLFGGLIGSMFSilqffsspltGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRM 148
Cdd:cd17317    24 DWLVALVQT-------IFFLGVLIGSLLF----------GYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRF 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024403389 149 VGGISKGNVSLCT-AIIADLHSPKARSkgmaMIGVAFSLGFTLGPMIGAYLAM 200
Cdd:cd17317    87 LVGVTSAGIFTVGfVLGMEIVGPKYRS----FVGILFGLFWALGYMLLALLAY 135
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-199 1.52e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.25  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRR---PVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT 161
Cdd:COG2271   214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2024403389 162 AIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLA 199
Cdd:COG2271   294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 90-205 8.49e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 48.39  E-value: 8.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHS 169
Cdd:cd06179    35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVP 114

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2024403389 170 PKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKG 205
Cdd:cd06179   115 NKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAG 150
Sugar_tr pfam00083
Sugar (and other) transporter;
82-196 8.60e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 48.04  E-value: 8.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  82 KYNSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAAS---RSFGVFLLSRMVGGISKGNVS 158
Cdd:pfam00083  41 LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGAS 120

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2024403389 159 -LCTAIIADLHSPKARSKgmamIGVAFSLGFTLGPMIGA 196
Cdd:pfam00083 121 vLAPMYISEIAPKKLRGA----LGSLYQLAITFGILLAY 155
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-198 1.35e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.18  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWA-ASRSFGVFLLSRMVGGISKGNVSLCT-A 162
Cdd:COG2223   239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVfA 318

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2024403389 163 IIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYL 198
Cdd:COG2223   319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 95-198 1.72e-05

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 46.89  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  95 MFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASY------ALWAASRSFGVFLLSRMVGGISKGNVSL---CTAIIA 165
Cdd:cd17386    38 MGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSlilvliVYFTTVPSVWWFYLSAIPLALFGGFTAFlsaSFAYIS 117

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2024403389 166 DLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYL 198
Cdd:cd17386   118 DISSEKKRTYRMAILEVALGLGGFLGSLLSGHL 150
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 105-199 2.09e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.78  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 105 PLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT-AIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17321    49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASlALIAATFPGERRGRALGLWGAV 128

                          90
                  ....*....|....*.
gi 2024403389 184 FSLGFTLGPMIGAYLA 199
Cdd:cd17321   129 VGIGAALGPLLGGLLL 144
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 85-201 2.68e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 46.55  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSilqffsspltGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGI-SKGNVSLCTAI 163
Cdd:TIGR00898 135 CFFVGVLLGSFVF----------GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVL 204

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIgAYLAME 201
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIPD 241
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 103-199 2.89e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.03  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 103 SSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADLHSPKARSKGMAMIGV 182
Cdd:cd17504    47 STPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSA 126

                          90
                  ....*....|....*..
gi 2024403389 183 AFSLGFTLGPMIGAYLA 199
Cdd:cd17504   127 TFGIGAGIGLPLGGWIV 143
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
283-425 4.70e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 4.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 283 ILGLAYFLYLFLFSGLEYTLSFLThQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGneiRVVKRAVLLLIPAF 359
Cdd:COG2271    14 LLFLAYFLNYLDRSNLSVAAPPLQ-ADLGLSAAQLGLLASAFFLGYALGQipaGLLADRFGRR---RVLAIGLLLWGLAT 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024403389 360 LLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSA 425
Cdd:COG2271    90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 85-175 4.81e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 45.64  E-value: 4.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSilqffsspltGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVS-LCTAI 163
Cdd:cd17359    44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113

                          90
                  ....*....|..
gi 2024403389 164 IADLHSPKARSK 175
Cdd:cd17359   114 IAEVAPAEIRGR 125
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 92-425 4.82e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 45.39  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  92 IGSMFSILQ---FFSSPLTGAVSDCLGRRPViLMTAMGLIAS-YALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADL 167
Cdd:cd17333    33 VSVIFSSQNagyLIGSLLAGFLMKRLGRRRT-LILGLLLISLaLALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 168 HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeTEKGEVFYLRSALLALTFAAADLIFiFFLLPETLPKEKRVSSVTtg 247
Cdd:cd17333   112 LFEESSATRLNVLHGFFGLGALIGPLIATSLL--TSELSWSWAYLIIGLIYLLLAILIL-LTLFPELPSARNPQQSVG-- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 248 fqaaadllspmalfRFSAVTQGKeapsdqnLQNLKILGLAyfLYLFLFSGLEYTL-----SFLTHQRF-QFSSMQQGKMF 321
Cdd:cd17333   187 --------------AFSASASRL-------LRNPSIILGA--LALFLYVGAETAFsswvpSYLVEKKHvSDGLAGYLLSG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 322 FFIGITMAVIQGGY-ARRIKPGneiRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSAS 400
Cdd:cd17333   244 FWVGITIGRLLGGPiSRRIKPH---TLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320

                         330       340
                  ....*....|....*....|....*
gi 2024403389 401 qKGRVMGILRSLGALARALGPVLSA 425
Cdd:cd17333   321 -KGKGTSVLLAAGSIGGAIIPFIMG 344
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 102-246 5.16e-05

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 45.57  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 102 FSSPLTGAVSDCLGRRPVILMTAMGLI--ASYALWAASRSFGV--FLLSRMVGGISkGNVSL----CTAIIADLHSPKAR 173
Cdd:cd17449    80 FSVTLLGPWSDSVGRRPVLILPSLGLAlqAAVYLLVMYLQLHVayFLIGRILSGLL-GDFNGilagCFAYVADVSDRRSR 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024403389 174 SKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKRVSSVTT 246
Cdd:cd17449   159 TFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWL-----VLALNLAAALYAAFCVGESVKEPKSARLFTT 226
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 83-198 6.79e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.23  E-value: 6.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  83 YNSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCT 161
Cdd:cd17324   230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFaAHSALQ 309

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2024403389 162 AIIADLhSPKARSKGMAMIGVAFSLGFTLGPMIGAYL 198
Cdd:cd17324   310 TRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLV 345
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 85-200 1.02e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.49  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSilqffsspltGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVS-LCTAI 163
Cdd:cd17315    42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASvLVPLY 111

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAM 200
Cdd:cd17315   112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSL 148
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
272-425 1.05e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 272 APSDQNLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQrFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIkpgNEIRVV 348
Cdd:COG2814     3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAplaGRLADRF---GRRRVL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024403389 349 KRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSA 425
Cdd:COG2814    79 LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
105-262 1.09e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 44.63  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 105 PLTGAVSDCLGRRPVILMTAmgLIASYALWAASRSFGV--FLLSRMVGGISKGNVSLCT-AIIADLHSPKARSKGMAMIG 181
Cdd:PRK10473   56 LFAGKIADRSGRKPVAIPGA--ALFIIASLLCSLAETSslFLAGRFLQGIGAGCCYVVAfAILRDTLDDRRRAKVLSLLN 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 182 VAFSLGFTLGPMIGAYLAMETEKGEVFYLRSallalTFAAADLIFIFFLLPETLPKEKRVSSVTTgFQAAADLLSPMALF 261
Cdd:PRK10473  134 GITCIIPVLAPVLGHLIMLKFPWQSLFYTMA-----AMGILVLLLSLFILKETRPARAPAASSKP-RENSESLLNRFFLS 207


                  .
gi 2024403389 262 R 262
Cdd:PRK10473  208 R 208
MFS_1 pfam07690
Major Facilitator Superfamily;
284-425 1.26e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 284 LGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPGNEIRVVKRAVLLLIPAFLLIG 363
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024403389 364 WAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSA 425
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG 142
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 90-423 1.42e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.10  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISK-GNVSLCTAIIADLH 168
Cdd:cd17319    41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEaGFFPGAIKALAEWF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmetekgEVFYLRSAllaltfaaadliFIFFLLPetlpkekrvssvttgf 248
Cdd:cd17319   121 PARERGRATGLFNSGAPLGAAIGPPLSGWLL------LLFGWRWA------------FIIEGLL---------------- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 249 qaaADLLSPMALFRfsavtqgkeapsdqnLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF--FIGI 326
Cdd:cd17319   167 ---GLLLAVLWWFY---------------LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAipFLAG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 327 TMAVIQGGY-ARRIKPGNEIRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 405
Cdd:cd17319   229 AIGMILGGRlSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308

                         330
                  ....*....|....*...
gi 2024403389 406 MGILRSLGALARALGPVL 423
Cdd:cd17319   309 GGLINSGGNLGGFVAPLL 326
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 90-234 1.73e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.79  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASR---SFGVFLLSRMVGGISKGnvsLCTAIIAD 166
Cdd:cd17357    52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKsakSPELLIFGRFLVGIACG---LSTGFVPM 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024403389 167 LHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLRSALLALTFAAADLIFIFFLLPET 234
Cdd:cd17357   129 YLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPES 196
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 28-197 2.51e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 43.32  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  28 VFLALLIDLLGFALILPLFPSILDyysqtedglylslQRGVDWFAAmvgmpperkynsvlfgGLIGSMFSILQFFSSPLT 107
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLE-------------REGVSTALI----------------GLVASAYYLGILLGSPLV 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 108 GAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT-AIIADLHSPKARSKGMAMIGVAFSL 186
Cdd:cd17477    52 PRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGL 131

                         170
                  ....*....|.
gi 2024403389 187 GFTLGPMIGAY 197
Cdd:cd17477   132 GFALGPLLLAL 142
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 90-210 2.70e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 43.50  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRP-VILMTAMGLIASYALWAASRsFGVFLLSRMVGGISKGNVSLCTAIIADLH 168
Cdd:pfam06609  81 GLFSTLWTMGQAVSILMMGRLTDRFGRRPfVIATHIIGLVGAIVGCTANK-FNTLLAAMTLLGVAAGPAGASPLFIGELM 159

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYL 210
Cdd:pfam06609 160 SNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYI 201
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 101-198 3.56e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 42.72  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 101 FFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGI-SKGNVSLCTAIIADLHSPKARSKGMAM 179
Cdd:cd17379    47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLfGKGGWMTGYVLVTEFVGSKYRRTVGIV 126

                          90
                  ....*....|....*....
gi 2024403389 180 IGVAFSLGFTLGPMIgAYL 198
Cdd:cd17379   127 YQMFFTLGLLILPGI-AYF 144
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-199 3.96e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.58  E-value: 3.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLC-TAIIADLH 168
Cdd:cd17489   230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAlQALAVDLV 309

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2024403389 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLA 199
Cdd:cd17489   310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
90-420 4.21e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQF---FSSPLTGAVSDCLG-----RRPVILMTAMGLIASYAL------WAASRSFGVFLLSRMVGGISKG 155
Cdd:COG2211    46 ALVGLILLVARLwdaITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAYT 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 156 NVSLC-TAIIADL-HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVF-YLRSALLALTFAAADLIFIFFLLP 232
Cdd:COG2211   126 LVNIPySALGAELtPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgYRLTALIFAVLGLLAFLLTFFGTK 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 233 ETLPKEKRVSSVttgFQAAADLLSPMALFRFSAVTqgkeapsdqnlqnlkilgLAYFLYLFLFSGLeytLSFLTHQRFQF 312
Cdd:COG2211   206 ERPVPEEEKVSL---KESLKALLKNRPFLLLLLAY------------------LLFFLALALVAAL---LLYYFKYVLGL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 313 SSMQQGKMFFFIGITMAVIQ---GGYARRIKPgneIRVVKRAVLLLIPAFLLIGWA--ANVTLLSAGLLLYSFAAAIVIP 387
Cdd:COG2211   262 SAALVGLLLALYFLAALLGAplwPRLAKRFGK---KKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2024403389 388 CLSAVVSG---YGSASQKGRVMGILRSLGALARALG 420
Cdd:COG2211   339 LPWAMLADvvdYDEWKTGRRREGLYFGIFTFAIKLG 374
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 105-240 7.03e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 41.98  E-value: 7.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 105 PLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGN-VSLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:TIGR00711  55 PLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPlIPLSFSTLLNIYPPEKRGRAMAIWGLT 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024403389 184 FSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLPKEKR 240
Cdd:TIGR00711 135 VLVAPALGPTLGGWIIENYHWRWIFLI-----NVPIGIIVVVVAFFILPRDKPAASE 186
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 105-198 7.07e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 7.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 105 PLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGN-VSLCTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17503    49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                          90
                  ....*....|....*
gi 2024403389 184 FSLGFTLGPMIGAYL 198
Cdd:cd17503   129 ILLAPAIGPTLGGWL 143
emrD PRK11652
multidrug transporter EmrD;
98-249 8.70e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 41.43  E-value: 8.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  98 ILQFFSSPLtgavSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIADLHSPKA--RS 174
Cdd:PRK11652   58 LSQLFYGPL----SDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGgVMARTLPRDLYEGTQlrHA 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024403389 175 KGMAMIGVAFSLgfTLGPMIGAYLAmetekgEVFYLRSA-LLALTFAAADLIFIFFLLPETLPKEKRVSSVTTGFQ 249
Cdd:PRK11652  134 NSLLNMGILVSP--LLAPLIGGLLT------TLFGWRACyLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYR 201
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
20-210 9.07e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 41.44  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  20 NCSRVITIVFLALLIDLLGFALILPLFPsildyysqtedgLYLSlQRGVDWFAAMVgmpperkynsvLFGGLIGSMFSIL 99
Cdd:PRK09874   11 NWKRNLTVAWLGCFLTGAAFSLVMPFLP------------LYVE-QLGVTGHSALN-----------MWSGLVFSITFLF 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 100 QFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAIIADlHSPKARSK-GMA 178
Cdd:PRK09874   67 SAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIAT-QVPRNKSGwALG 145

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2024403389 179 MIGVAFSLGFTLGPMIGAYLAMETEKGEVFYL 210
Cdd:PRK09874  146 TLSTGGVSGALLGPLAGGLLADSYGLRPVFFI 177
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-200 1.41e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 40.65  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  87 LFGGLIGSMFSilqffsspltGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAIIA 165
Cdd:cd17365    44 LFGMAIGALLA----------GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAmPNAITLVS 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024403389 166 DLHSPKARSkgmAMIGVAFSlGFTLGPMIGAYLAM 200
Cdd:cd17365   114 EYAPARRRS---LAVTLMFC-GYPLGAALGGFLAA 144
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 308-427 1.42e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 308 QRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGneiRVVKRAVLLLIPAFLLIGWAANVTLLSAGLLLYSFAAAI 384
Cdd:cd17478    24 AKLGLSYAQAGLLVSVFSITSSLLQplfGYLADRKPRR---YLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024403389 385 VIPcLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATA 427
Cdd:cd17478   101 FHP-EGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL 142
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 85-210 1.59e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSILQFFSSPLTGAVSD-CLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVS-LCTA 162
Cdd:cd06174   237 SVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLpLSFA 316

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2024403389 163 IIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYL 210
Cdd:cd06174   317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 75-204 1.67e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 40.70  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  75 VGMPPERKYNSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMG-LIASYALWAASRSFGVFLLSRMVGGIS 153
Cdd:cd17356    33 FADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIyIIGAIIQVAAIGKWYQLIVGRIIAGLG 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024403389 154 KGNVSLCTAIIADLHSPKARsKGmaMIGVAFSLGFTLGPMIGAYLAMETEK 204
Cdd:cd17356   113 VGFASVLVPVYQSEVAPKHI-RG--TLVSLYQLAITIGILVAYCINYGTHK 160
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 84-199 2.66e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 40.20  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  84 NSVLFGGLIGSmfsILQFFSSPLTGAVSDCLGRRPVILMTAMGLIAS----YALWAASRSFGVFLLSRMVGGISKGNV-S 158
Cdd:cd17369   264 STVLLAVLIAS---VVAAITIPLFGWLSDRVGRRPVYLAGALLAALFafpfFWLLDTGSTWLIVLAAVVVLGVLHGMMyG 340

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2024403389 159 LCTAIIADLHSPKARSKGMAmigVAFSLGFTLG----PMIGAYLA 199
Cdd:cd17369   341 PQAAFLAELFPTRVRYTGAS---LGYQLGAILGggfaPLIATALV 382
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 85-198 3.02e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.83  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNV-SLCTAI 163
Cdd:cd17370   232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAA 311

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYL 198
Cdd:cd17370   312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL 346
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
90-423 3.30e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.86  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGG--ISKGNVsLCTAIIADl 167
Cdd:COG2807    56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagIAVGNV-LLPGLIKR- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 168 HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmetekgEVFYLRSALLALTFAAADLIFIFFLLPETLPKEKRVSSVTTG 247
Cdd:COG2807   134 WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLA------AALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 248 FQAAadLLSPMALfrfsavtqgkeapsdqnlqnlkILGLAYFLYLFLFSGLeytLSFLTH--QRFQFSSMQQGKMFF--- 322
Cdd:COG2807   208 LRSL--WRSPLAW----------------------LLTLFFGLQSLLYYAV---VAWLPPilRDAGLSAATAGLLLSlfq 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 323 FIGITMAVIQGGYARRIKPgneirvvKRAVLLLIPAFLLIG----WAANVTLLSAGLLLYSFAAAIVIPCLSAVVSGY-G 397
Cdd:COG2807   261 LAGIPGSLLVPLLADRLGD-------RRPLLLLLGLLGLAGllglLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRaR 333

                         330       340
                  ....*....|....*....|....*.
gi 2024403389 398 SASQKGRVMGILRSLGALARALGPVL 423
Cdd:COG2807   334 TPAEAAALSGMAQSVGYLLAALGPLL 359
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 82-196 3.32e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  82 KYNSVLFGGLIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCT 161
Cdd:cd17478   225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2024403389 162 AIIADLhspKARSKGMA---MIGVAFSLGFTLGPMIGA 196
Cdd:cd17478   305 VLAQEL---LPGNVGLAsglMMGLSFGLGGIGAPVLGA 339
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 90-200 5.00e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.07  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  90 GLIGSMFSILQFFSSPLTGAVSDCLG-RRPVILMTAMGLIASYALWAASRSFGVFLL-SRMVGGISKGNVSLCTAII--- 164
Cdd:cd17471    35 GIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLvGVVLLSLGAAAFPQLFALArey 114

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2024403389 165 ADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAM 200
Cdd:cd17471   115 ADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLD 150
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 98-194 5.28e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 39.28  E-value: 5.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  98 ILQFFSSPLTGAVSDCLGRRPVILMTAMGLIA----SYALWAASRSFGVFLLSRMVGG--ISKGNVSLCTAIiadlhspk 171
Cdd:cd17368   269 VANFIWAPLGGALSDRIGRRPVLLVITLAALVtlypVFAWLTAAPSFGRLLLVLLVLSffFGMYGGAMVVAL-------- 340

                          90       100
                  ....*....|....*....|...
gi 2024403389 172 ARSKGMAMIGVAFSLGFTLGPMI 194
Cdd:cd17368   341 VELFPVRVRSTGFSLVYALAVAI 363
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 85-426 5.91e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSILQFfsspltGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGN-VSLCTAI 163
Cdd:TIGR00895  56 FLFSAGLIGMAFGALFF------GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGlMPNLNAL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMETEKGEVFYLrsallALTFAAADLIFIFFLLPETLP--KEKRV 241
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-----GGIAPLLLLLLLMRFLPESIDflVSKRP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 242 SSVTTGFQAAADLLSPMALFRF---SAVTQGKEAP-----SDQNLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFS 313
Cdd:TIGR00895 205 ETVRRIVNAIAPQMQAEAQSALpeqKSTQGTKRSVfkalfQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSL 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 314 SMQQGKMFFFI--GITMAVIQGGYARRIKPGneirvVKRAVLLLIPAFLLIGWAA--NVTLLSAGLLLYSFAAAIVIPCL 389
Cdd:TIGR00895 285 SLAATGGALFNfgGVIGSIIFGWLADRLGPR-----VTALLLLLGAVFAVLVGSTlfSPTLLLLLGAIAGFFVNGGQSGL 359

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2024403389 390 SAVVSGYGSASQKGRVMGILRSLGALARALGPVLSAT 426
Cdd:TIGR00895 360 YALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 24-195 7.12e-03

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 38.71  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  24 VITIVFLALLIDLLGFALILPLFPSILDyysqtEDGLylslqrgvdwfaamvgmpperkynsvlfgglIGSMFS---ILQ 100
Cdd:cd17384     1 VLVIVYVALLLDNMLLTVVVPIIPDYLN-----ENVR-------------------------------VGLLFAskaLVQ 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389 101 FFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISkgnvSLCTAI-----IADL-HSPKARS 174
Cdd:cd17384    45 LITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVG----SACSSVagmgmLASLyPDDKERG 120

                         170       180
                  ....*....|....*....|...
gi 2024403389 175 KGM--AMIGVAfsLGFTLGPMIG 195
Cdd:cd17384   121 KAMgiALGGLA--LGVLVGPPFG 141
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 89-200 7.14e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  89 GGLIGSMFSILQFF---SSPLTGAVSDC-LGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKG-NVSLCTAI 163
Cdd:cd17474   233 PIIIGLLFAGWSVLlalGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTL 312

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2024403389 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAM 200
Cdd:cd17474   313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 91-173 7.15e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 38.79  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  91 LIGSMFSILQFFSSPLTGAVSDCLGRRPVILMTAMGLIASYALWAASRSFGVFLLSRMVGGISKGNVSLCTAI-IADLHS 169
Cdd:cd17360    39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLyIAEAAP 118


                  ....
gi 2024403389 170 PKAR 173
Cdd:cd17360   119 PRIR 122
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 85-201 8.68e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.36  E-value: 8.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024403389  85 SVLFGGLIGSMFSILQFFSSPLTGAVSDCLGR-RPVILMTAMGLIASYALWAASRSFGVFLLsrMVGGIS---KGNVSLC 160
Cdd:cd17353   247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRkNTLSIAFLIQGVAMFLLPFIGSVAVLFVL--GVALIGfcyGGGFALF 324

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2024403389 161 TAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAME 201
Cdd:cd17353   325 PALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYT 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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