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Conserved domains on  [gi|1381360460|ref|XP_024657033|]
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platelet-derived growth factor subunit A-like, partial [Maylandia zebra]

Protein Classification

PDGF_N and PDGF domain-containing protein( domain architecture ID 10520087)

protein containing domains gly_rich_SclB, PDGF_N, and PDGF

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 14-91 6.12e-36

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


:

Pssm-ID: 461394  Cd Length: 78  Bit Score: 118.69  E-value: 6.12e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381360460  14 QESPLPQELLERLSRSEIRSISDLQRLLEIDSVENEVIEE--TKHSYHKDFSHSFPDLKRAHTHTRHRRStvVEEALPAV 91
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEveTKHRAHSDHSSSSVDLKRRQLHSRRKRS--IEEAVPAV 78
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 90-146 1.10e-16

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member smart00141:

Pssm-ID: 444701  Cd Length: 83  Bit Score: 69.76  E-value: 1.10e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381360460   90 AVCKVRTAIYEIPRSQVDPTsaNFIIWPPCVEVKRCTGCCNTSNMRCQAARKHYRTV 146
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTM 55
 
Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 14-91 6.12e-36

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 118.69  E-value: 6.12e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381360460  14 QESPLPQELLERLSRSEIRSISDLQRLLEIDSVENEVIEE--TKHSYHKDFSHSFPDLKRAHTHTRHRRStvVEEALPAV 91
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEveTKHRAHSDHSSSSVDLKRRQLHSRRKRS--IEEAVPAV 78
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 90-146 1.10e-16

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 69.76  E-value: 1.10e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381360460   90 AVCKVRTAIYEIPRSQVDPTsaNFIIWPPCVEVKRCTGCCNTSNMRCQAARKHYRTV 146
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTM 55
PDGF pfam00341
PDGF/VEGF domain;
92-147 1.11e-14

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 64.62  E-value: 1.11e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1381360460  92 CKVRTAIYEIPRSQVDPTSANFIiwPPCVEVKRCTGCCNTSNMRCQAARKHYRTVK 147
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQ 54
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 90-147 4.34e-14

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 63.16  E-value: 4.34e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1381360460  90 AVCKVRTAIYEIPRSQVDPTsaNFIIWPPCVEVKRCTGCCNTSNMRCQAARKHYRTVK 147
Cdd:cd00135     1 SSCKPRETLVEISEELPDET--NTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQ 56
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 117-138 8.80e-03

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 34.60  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|..
gi 1381360460 117 PPCVEVKRCTGCCNTSNMRCQA 138
Cdd:PHA02661   71 PRCVTVRRCGGCCNDESQICTP 92
 
Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 14-91 6.12e-36

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 118.69  E-value: 6.12e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381360460  14 QESPLPQELLERLSRSEIRSISDLQRLLEIDSVENEVIEE--TKHSYHKDFSHSFPDLKRAHTHTRHRRStvVEEALPAV 91
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEveTKHRAHSDHSSSSVDLKRRQLHSRRKRS--IEEAVPAV 78
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 90-146 1.10e-16

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 69.76  E-value: 1.10e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381360460   90 AVCKVRTAIYEIPRSQVDPTsaNFIIWPPCVEVKRCTGCCNTSNMRCQAARKHYRTV 146
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTM 55
PDGF pfam00341
PDGF/VEGF domain;
92-147 1.11e-14

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 64.62  E-value: 1.11e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1381360460  92 CKVRTAIYEIPRSQVDPTSANFIiwPPCVEVKRCTGCCNTSNMRCQAARKHYRTVK 147
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQ 54
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 90-147 4.34e-14

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 63.16  E-value: 4.34e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1381360460  90 AVCKVRTAIYEIPRSQVDPTsaNFIIWPPCVEVKRCTGCCNTSNMRCQAARKHYRTVK 147
Cdd:cd00135     1 SSCKPRETLVEISEELPDET--NTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQ 56
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 117-138 8.80e-03

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 34.60  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|..
gi 1381360460 117 PPCVEVKRCTGCCNTSNMRCQA 138
Cdd:PHA02661   71 PRCVTVRRCGGCCNDESQICTP 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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