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Conserved domains on  [gi|1379669823|ref|XP_024627437|]
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WD repeat domain-containing protein 83 [Medicago truncatula]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 7.30e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 215.66  E-value: 7.30e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  10 EVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDV 89
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  90 ATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLTKTE--IIGGSVDGT 167
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 168 VRTFDMRIGREISDSLG--QPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYkldCCLTNTDAH-VT 244
Cdd:cd00200   159 IKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN---SVAFSPDGYlLA 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379669823 245 GGSEDGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVWK 298
Cdd:cd00200   236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 7.30e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 215.66  E-value: 7.30e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  10 EVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDV 89
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  90 ATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLTKTE--IIGGSVDGT 167
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 168 VRTFDMRIGREISDSLG--QPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYkldCCLTNTDAH-VT 244
Cdd:cd00200   159 IKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN---SVAFSPDGYlLA 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379669823 245 GGSEDGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVWK 298
Cdd:cd00200   236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-299 1.41e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.53  E-value: 1.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYW 87
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  88 DVATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLT---KTeIIGGSV 164
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSpdgRL-LASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 165 DGTVRTFDMRIGREIS--DSLGQPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYKLdcCLTNTDAH 242
Cdd:COG2319   267 DGTVRLWDLATGELLRtlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379669823 243 VTGGSEDGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVWKT 299
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-46 1.59e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 1.59e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1379669823    7 PRKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWN 46
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
8-46 1.23e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWN 46
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 14-200 1.11e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  14 LKGHEGGVLAARFNSDGNYIL-SCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDVATG 92
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  93 RVIRKFRGHDG-EVNGVKFNEYSSVVVSAGYDQS----LRAWDCRSHSTePIQIIDTFADSVMSVCL----TKTEIIGGS 163
Cdd:PTZ00421  201 TIVSSVEAHASaKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMAS-PYSTVDLDQSSALFIPFfdedTNLLYIGSK 279

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1379669823 164 VDGTVRTFDMRIGREIsdslgqpvNCISMSND----GNCIL 200
Cdd:PTZ00421  280 GEGNIRCFELMNERLT--------FCSSYSSVephkGLCMM 312
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 7.30e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 215.66  E-value: 7.30e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  10 EVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDV 89
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  90 ATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLTKTE--IIGGSVDGT 167
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 168 VRTFDMRIGREISDSLG--QPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYkldCCLTNTDAH-VT 244
Cdd:cd00200   159 IKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN---SVAFSPDGYlLA 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379669823 245 GGSEDGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVWK 298
Cdd:cd00200   236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-299 1.41e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.53  E-value: 1.41e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYW 87
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  88 DVATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLT---KTeIIGGSV 164
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSpdgRL-LASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 165 DGTVRTFDMRIGREIS--DSLGQPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYKLdcCLTNTDAH 242
Cdd:COG2319   267 DGTVRLWDLATGELLRtlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379669823 243 VTGGSEDGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVWKT 299
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
5-297 8.69e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 8.69e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   5 DLPRKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQV 84
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  85 YYWDVATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLT---KTeIIG 161
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSpdgKL-LAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 162 GSVDGTVRTFDMRIGREIS--DSLGQPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYKLdcCLTNT 239
Cdd:COG2319   222 GSADGTVRLWDLATGKLLRtlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPD 299

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1379669823 240 DAHVTGGSEDGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVW 297
Cdd:COG2319   300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
13-297 1.72e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 1.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  13 VLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDVATG 92
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  93 RVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDcrSHSTEPIQIIDTFADSVMSVCLTK--TEIIGGSVDGTVRT 170
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 171 FDMRIGREISDSLG--QPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYKLDccLTNTDAHVTGGSE 248
Cdd:COG2319   189 WDLATGKLLRTLTGhtGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA--FSPDGRLLASGSA 266

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1379669823 249 DGFVYFWDLVDASVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVW 297
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
9-215 3.94e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 3.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   9 KEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWD 88
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  89 VATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDCRSHstEPIQIIDTFADSVMSVCLT--KTEIIGGSVDG 166
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSpdGKTLASGSDDG 352

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1379669823 167 TVRTFDMRIGREISDSLG--QPVNCISMSNDGNCILAGCLDSTVRLLDRTT 215
Cdd:COG2319   353 TVRLWDLATGELLRTLTGhtGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
25-297 4.56e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 4.56e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  25 RFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDVATGRVIRKFRGHDGE 104
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 105 VNGVKFNEYSSVVVSAGYDQSLRAWDCRshSTEPIQIIDTFADSVMSVCLTK--TEIIGGSVDGTVRTFDMRIGREISDS 182
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 183 LG--QPVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYKLdcCLTNTDAHVTGGSEDGFVYFWDLVDA 260
Cdd:COG2319   159 TGhsGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDLATG 236

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1379669823 261 SVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVW 297
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
8-174 5.42e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.02  E-value: 5.42e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYW 87
Cdd:COG2319   236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  88 DVATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWDcrSHSTEPIQIIDTFADSVMSVCLTK--TEIIGGSVD 165
Cdd:COG2319   316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD--LATGELLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393


                  ....*....
gi 1379669823 166 GTVRTFDMR 174
Cdd:COG2319   394 GTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-130 9.09e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 9.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   9 KEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWD 88
Cdd:cd00200   168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1379669823  89 VATGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWD 130
Cdd:cd00200   248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-299 3.67e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 3.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 186 PVNCISMSNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKSYKLDCCLtNTDAHVTGGSeDGFVYFWDLVDASVVSK 265
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSS-DKTIRLWDLETGECVRT 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1379669823 266 FRAHTSVVTSVSYHPKENCMITSSVDGTIRVWKT 299
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
8-91 3.09e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 3.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYW 87
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                  ....
gi 1379669823  88 DVAT 91
Cdd:COG2319   400 DLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-46 1.59e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 1.59e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1379669823    7 PRKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWN 46
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
8-46 1.23e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWN 46
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 14-200 1.11e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  14 LKGHEGGVLAARFNSDGNYIL-SCGKDRTIRLWNPHRGIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWDVATG 92
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  93 RVIRKFRGHDG-EVNGVKFNEYSSVVVSAGYDQS----LRAWDCRSHSTePIQIIDTFADSVMSVCL----TKTEIIGGS 163
Cdd:PTZ00421  201 TIVSSVEAHASaKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMAS-PYSTVDLDQSSALFIPFfdedTNLLYIGSK 279

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1379669823 164 VDGTVRTFDMRIGREIsdslgqpvNCISMSND----GNCIL 200
Cdd:PTZ00421  280 GEGNIRCFELMNERLT--------FCSSYSSVephkGLCMM 312
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-298 1.73e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.73e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1379669823  261 SVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVWK 298
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 4.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.91e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1379669823   91 TGRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
261-297 5.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1379669823 261 SVVSKFRAHTSVVTSVSYHPKENCMITSSVDGTIRVW 297
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 21-296 8.17e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 8.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  21 VLAARFNSDGNYILSCGKDRTIRLW------NPHRGIHIKTYKSHGREVRDVHVTTD--NSKLCSCGGDRQVYYWDVATG 92
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFecesiiKDGRDIHYPVVELASRSKLSGICWNSyiKSQVASSNFEGVVQVWDVARS 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  93 RVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQ-SLRAWDCRSHSTepIQIIDTFADsvmsVCL------TKTEIIGGSVD 165
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKAN----ICCvqfpseSGRSLAFGSAD 639

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 166 GTVRTFDMR---------IGREISDSLGQPVncismsnDGNCILAGCLDSTVRLLDRTTG------ELLQEYKGHTN-KS 229
Cdd:PLN00181  640 HKVYYYDLRnpklplctmIGHSKTVSYVRFV-------DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNvKN 712

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 230 YkldCCLTNTDAHVTGGSEDG--FVYFWDLVDASVVSKFRAHTSV-----------VTSVSYHPKENCMITSSVDGTIRV 296
Cdd:PLN00181  713 F---VGLSVSDGYIATGSETNevFVYHKAFPMPVLSYKFKTIDPVsglevddasqfISSVCWRGQSSTLVAANSTGNIKI 789
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-46 3.43e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 3.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379669823   8 RKEVNVLKGHEGGVLAARFNSDGNYILSCGKDRTIRLWN 46
Cdd:cd00200   251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
92-130 1.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379669823  92 GRVIRKFRGHDGEVNGVKFNEYSSVVVSAGYDQSLRAWD 130
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-297 2.19e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.77  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 105 VNGVKFNEYSSVVVSAGYDQSLRAWDCRS--HSTEPIQ--IIDTFADSVMS-VCLT---KTEIIGGSVDGTVRTFDMRIG 176
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESiiKDGRDIHypVVELASRSKLSgICWNsyiKSQVASSNFEGVVQVWDVARS 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 177 REISDSLGQPVNCISM---SNDGNCILAGCLDSTVRLLDRTTGELLQEYKGHTNKsykldCCL---TNTDAHVTGGSEDG 250
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIdysSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI-----CCVqfpSESGRSLAFGSADH 640

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1379669823 251 FVYFWDLVDASV-VSKFRAHTSVVTSVSYhPKENCMITSSVDGTIRVW 297
Cdd:PLN00181  641 KVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-88 1.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1379669823   50 GIHIKTYKSHGREVRDVHVTTDNSKLCSCGGDRQVYYWD 88
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 14-201 2.30e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  14 LKGHEGGVLAARFNSDGNYIL-SCGKDRTIRLWN-PHRGIHIKtykshgrEVRDvhvttdnsKLCScggdrqvyywdvat 91
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWEiPHNDESVK-------EIKD--------PQCI-------------- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823  92 grvirkFRGHDGEVNGVKFNEYSSVVV-SAGYDQSLRAWDCRSHStEPIQIIdtfadsvMSVCLT--KTEIIGGSVDGTV 168
Cdd:PTZ00420  121 ------LKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIENEK-RAFQIN-------MPKKLSslKWNIKGNLLSGTC 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1379669823 169 RTFDMRI----GREISDSL-----GQPVNCI---SMSNDGNCILA 201
Cdd:PTZ00420  187 VGKHMHIidprKQEIASSFhihdgGKNTKNIwidGLGGDDNYILS 231
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 104-195 9.20e-03

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 36.96  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379669823 104 EVNGVKFNEYSSVVVSAGYDQSLRAWDCRShsTEPIQIIDTFADSVMSVCLTKTE-IIGGSVDGTVRTFDMRIGREISD- 181
Cdd:pfam17005   2 EIYSIDISKKGSYILYGGKDDTCTVYDFEN--LDLVSIVEGFSDSVIFCKFLDDDlILVVTLDGTIMESLLKNDQEIENt 79

                          90
                  ....*....|....
gi 1379669823 182 SLGQPVNCISMSND 195
Cdd:pfam17005  80 KINEDISTVKVTDD 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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