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Conserved domains on  [gi|1376271640|ref|XP_024513590|]
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cytoplasm protein, putative [Cryptococcus neoformans var. neoformans JEC21]

Protein Classification

DOCK_N and DHR2_DOCK domain-containing protein( domain architecture ID 11241287)

protein containing domains DOCK_N, C2_DOCK180_related, and DHR2_DOCK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DOCK_N pfam16172
DOCK N-terminus; This family is found near to the N-terminus of dedicator of cytokinesis (DOCK) ...
 309-758 6.40e-95

DOCK N-terminus; This family is found near to the N-terminus of dedicator of cytokinesis (DOCK) proteins, between the variant SH3 domain (pfam07653) and the C2 domain (pfam14429).


:

Pssm-ID: 465040  Cd Length: 317  Bit Score: 310.21  E-value: 6.40e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  309 GDSTAGGQQWPLIDEIACAIREWYSRLPTYLANREYRLFNTVTQHIDALSLGRRQLLSQMLSGDELVRVRRECVSRLVKC 388
Cdd:pfam16172    2 GDETPTSAEEPLVDEIASCLREWHSTLHELLLSRQYQLFDKLSQLIYELDLARRQLLHGVLTADELKELREKTVWDLVRG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  389 NVAQGLDVIVRNLEDGSVVVVDRERAysgtkwvggISCYVYQVRLAYIDVipldnvfaevflTPQKAVFQSHTltsskge 468
Cdd:pfam16172   82 NKLLGLDVIVRDPTGRGRLLTDDDSV---------VELYKLQSEMSLLDE------------PPTPQVEPDAT------- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  469 lsdlpagSFYHLFLELRAFVANpcAPGETAELYFSLYNKADKRFISEEYCLILNHYGSPARDSEQrlGRIRTLFTDLKVE 548
Cdd:pfam16172  134 -------SLHHLLVDVKNFVGS--SIGEDAELFFSLYDKKELKFLSENFVVRLPSNGMPKSLAQS--LNLRTLFTDLSSS 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  549 DLA-PDTYLVCKIIRNgamkmrsddsmlpaslsasvagqrsslygisetglsghnqwrgdslmnltddsfsvtsaygpet 627
Cdd:pfam16172  203 DLArSKLYLVCKVIRN---------------------------------------------------------------- 218

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  628 hrpptttgttnapsstigggsgfggkvrVRRPLGWAVMLLPPMSKLMgdglDRDGGGVEQSVKIYVPREEKDFAGMFDDV 707
Cdd:pfam16172  219 ----------------------------VRRPFGVAVLDLTDILKGL----KQSDEEVEHVVPIWSPNNESDFDELHRDI 266

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1376271640  708 IHNRVKQYMDFSRAQSIVLYLKSLRGPAPQLVREHPSLLLDIPLTSRLSFP 758
Cdd:pfam16172  267 IKSITGKYEKSPRAERLWVSLKLFHGDAEQLRKENPTLLHNVAITRKLGFP 317
DHR2_DOCK cd11684
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; DOCK proteins ...
 1709-2100 1.26e-79

Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; DOCK proteins comprise a family of atypical guanine nucleotide exchange factors (GEFs) that lack the conventional Dbl homology (DH) domain. As GEFs, they activate the small GTPases Rac and Cdc42 by exchanging bound GDP for free GTP. They are also called the CZH (CED-5, Dock180, and MBC-zizimin homology) family, after the first family members identified. Dock180 was first isolated as a binding partner for the adaptor protein Crk. The Caenorhabditis elegans protein, Ced-5, is essential for cell migration and phagocytosis, while the Drosophila ortholog, Myoblast city (MBC), is necessary for myoblast fusion and dorsal closure. DOCKs are divided into four classes (A-D) based on sequence similarity and domain architecture: class A includes Dock1 (or Dock180), 2 and 5; class B includes Dock3 and 4; class C includes Dock6, 7, and 8; and class D includes Dock9, 10 and 11. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1, and DHR-2 (also called CZH2 or Docker). This alignment model represents the DHR-2 domain of DOCK proteins, which contains the catalytic GEF activity for Rac and/or Cdc42.


:

Pssm-ID: 212566 [Multi-domain]  Cd Length: 392  Bit Score: 269.17  E-value: 1.26e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWkvgDEHWVDAGRWGDLELPAHSEFARKQAIYYHILGYLAQAEAHE 1788
Cdd:cd11684      2 LYIRYLHKLADLHEERGNYVEAALCLLLHADLYAW---DLKALVPALAESLSFPEQTSFERKEALYKKAIDLFDKGKAWE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1789 FSINLCQELITQHQRlTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGDIL-SLDKNKDYVIRAQVGQKYTDFC 1867
Cdd:cd11684     79 FAIALYKELIPQYEN-NFDYAKLSEVHRKIAKLYEKIAEKDRLFPTYFRVGFYGKGFpESLRGKEFIYRGPEFERLGDFC 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1868 DILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFgeNVSDNVQSYWRWNGIRRFSSVRPYLKDPGER 1947
Cdd:cd11684    158 ERLKSLYPGAEIIQSSEEPDDEILDSEGQYIQITSVEPYFDDEDLVS--RAAPGVRQFYRNNNINTFVYERPFTKGGKKS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1948 ETALA--WTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAIMEIKAAIKSLQKS-SRGENGRLPESKALGTAINNAV 2024
Cdd:cd11684    236 QNEITdqWKERTILTTEESFPTILRRSEVVSIEEIELSPIENAIEDIEKKTEELRSLiNKYRSGDSPNVNPLQMLLQGTV 315

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376271640 2025 DSPVSERIKRYRELFIEGTYLDSHPEDcEEIQQLKTAIIQYVRAIQDSLEVHKRICRDV--AFYEILKNQLYKSFAEE 2100
Cdd:cd11684    316 DAAVNGGPVAYAEAFLSEEYLSNYPEA-EKVKKLKEAFEEFLEILKRGLALHAKLCPPEmaPLHEELEEGFEKLFKEL 392
DOCK-C2 pfam14429
C2 domain in Dock180 and Zizimin proteins; The Dock180/Dock1 and Zizimin proteins are atypical ...
 763-971 2.62e-45

C2 domain in Dock180 and Zizimin proteins; The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.


:

Pssm-ID: 464171  Cd Length: 185  Bit Score: 162.39  E-value: 2.62e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  763 PGHSRHDLYIKLCsasftsapssssgsmRLK-KNVSPGYNSDVQVTMEMRKADGTVVEDAImAGGSGEPGTSQWNSMVFH 841
Cdd:pfam14429    1 PGDYRNDLYVTPK---------------SGNfSKQKKSSARNIEVTVEVRDSDGEPLPNCI-YGGSGGPFVTEFKSTVYY 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  842 HNDKPVYDELVKIPLPVQLSE-YHLFLTFGSKSKNKQMtaDEAEKPFAFTYLPISTAN-IFVKDDDHELVLYHMDKnfqs 919
Cdd:pfam14429   65 HNKSPTWYEEIKIALPAELTPkHHLLFTFYHVSCDEKK--DKVEKPFGYAFLPLLDDDgAFLRDGEHTLPVYKYDE---- 138

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376271640  920 TPSLYFDAPhsakdWAHDPVLPDTILKGMSPLRDRVMIRTRLCSSVHTQDET 971
Cdd:pfam14429  139 LPPGYLSLP-----WSSGGEKESSALPGLKGGKDLFKVRTRLCSTKYTQDEH 185
COG5099 super family cl34901
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ...
 2106-2268 2.49e-03

RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5099:

Pssm-ID: 227430 [Multi-domain]  Cd Length: 777  Bit Score: 43.20  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2106 SSASSDDHFPSFP-SFAPDSSDHGKYYSSTKSQPSisiSFHRSSADRSFSDHREPNITSTMGSEGYNLPPL------RIG 2178
Cdd:COG5099     71 TSSSSSRRKPSGSwSVAISSSTSGSQSLLMELPSS---SFNPSTSSRNKSNSALSSTQQGNANSSVTLSSStassmfNSN 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2179 RLPSsggqPLTVHSAST----------HTHTPRESTSTTHNTPSTPVRAGITTPTSPPFR------TPSRTGSARKKDHR 2242
Cdd:COG5099    148 KLPL----PNPNHSNSAttnqsgssfiNTPASSSSQPLTNLVVSSIKRFPYLTSLSPFFNylidpsSDSATASADTSPSF 223

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1376271640 2243 --------RSLTSPLGPSELGHGKNRSVSSLSIR 2268
Cdd:COG5099    224 npppnlspNNLFSTSDLSPLPDTQSVENNIILNS 257
 
Name Accession Description Interval E-value
DOCK_N pfam16172
DOCK N-terminus; This family is found near to the N-terminus of dedicator of cytokinesis (DOCK) ...
 309-758 6.40e-95

DOCK N-terminus; This family is found near to the N-terminus of dedicator of cytokinesis (DOCK) proteins, between the variant SH3 domain (pfam07653) and the C2 domain (pfam14429).


Pssm-ID: 465040  Cd Length: 317  Bit Score: 310.21  E-value: 6.40e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  309 GDSTAGGQQWPLIDEIACAIREWYSRLPTYLANREYRLFNTVTQHIDALSLGRRQLLSQMLSGDELVRVRRECVSRLVKC 388
Cdd:pfam16172    2 GDETPTSAEEPLVDEIASCLREWHSTLHELLLSRQYQLFDKLSQLIYELDLARRQLLHGVLTADELKELREKTVWDLVRG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  389 NVAQGLDVIVRNLEDGSVVVVDRERAysgtkwvggISCYVYQVRLAYIDVipldnvfaevflTPQKAVFQSHTltsskge 468
Cdd:pfam16172   82 NKLLGLDVIVRDPTGRGRLLTDDDSV---------VELYKLQSEMSLLDE------------PPTPQVEPDAT------- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  469 lsdlpagSFYHLFLELRAFVANpcAPGETAELYFSLYNKADKRFISEEYCLILNHYGSPARDSEQrlGRIRTLFTDLKVE 548
Cdd:pfam16172  134 -------SLHHLLVDVKNFVGS--SIGEDAELFFSLYDKKELKFLSENFVVRLPSNGMPKSLAQS--LNLRTLFTDLSSS 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  549 DLA-PDTYLVCKIIRNgamkmrsddsmlpaslsasvagqrsslygisetglsghnqwrgdslmnltddsfsvtsaygpet 627
Cdd:pfam16172  203 DLArSKLYLVCKVIRN---------------------------------------------------------------- 218

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  628 hrpptttgttnapsstigggsgfggkvrVRRPLGWAVMLLPPMSKLMgdglDRDGGGVEQSVKIYVPREEKDFAGMFDDV 707
Cdd:pfam16172  219 ----------------------------VRRPFGVAVLDLTDILKGL----KQSDEEVEHVVPIWSPNNESDFDELHRDI 266

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1376271640  708 IHNRVKQYMDFSRAQSIVLYLKSLRGPAPQLVREHPSLLLDIPLTSRLSFP 758
Cdd:pfam16172  267 IKSITGKYEKSPRAERLWVSLKLFHGDAEQLRKENPTLLHNVAITRKLGFP 317
DHR2_DOCK cd11684
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; DOCK proteins ...
 1709-2100 1.26e-79

Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; DOCK proteins comprise a family of atypical guanine nucleotide exchange factors (GEFs) that lack the conventional Dbl homology (DH) domain. As GEFs, they activate the small GTPases Rac and Cdc42 by exchanging bound GDP for free GTP. They are also called the CZH (CED-5, Dock180, and MBC-zizimin homology) family, after the first family members identified. Dock180 was first isolated as a binding partner for the adaptor protein Crk. The Caenorhabditis elegans protein, Ced-5, is essential for cell migration and phagocytosis, while the Drosophila ortholog, Myoblast city (MBC), is necessary for myoblast fusion and dorsal closure. DOCKs are divided into four classes (A-D) based on sequence similarity and domain architecture: class A includes Dock1 (or Dock180), 2 and 5; class B includes Dock3 and 4; class C includes Dock6, 7, and 8; and class D includes Dock9, 10 and 11. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1, and DHR-2 (also called CZH2 or Docker). This alignment model represents the DHR-2 domain of DOCK proteins, which contains the catalytic GEF activity for Rac and/or Cdc42.


Pssm-ID: 212566 [Multi-domain]  Cd Length: 392  Bit Score: 269.17  E-value: 1.26e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWkvgDEHWVDAGRWGDLELPAHSEFARKQAIYYHILGYLAQAEAHE 1788
Cdd:cd11684      2 LYIRYLHKLADLHEERGNYVEAALCLLLHADLYAW---DLKALVPALAESLSFPEQTSFERKEALYKKAIDLFDKGKAWE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1789 FSINLCQELITQHQRlTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGDIL-SLDKNKDYVIRAQVGQKYTDFC 1867
Cdd:cd11684     79 FAIALYKELIPQYEN-NFDYAKLSEVHRKIAKLYEKIAEKDRLFPTYFRVGFYGKGFpESLRGKEFIYRGPEFERLGDFC 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1868 DILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFgeNVSDNVQSYWRWNGIRRFSSVRPYLKDPGER 1947
Cdd:cd11684    158 ERLKSLYPGAEIIQSSEEPDDEILDSEGQYIQITSVEPYFDDEDLVS--RAAPGVRQFYRNNNINTFVYERPFTKGGKKS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1948 ETALA--WTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAIMEIKAAIKSLQKS-SRGENGRLPESKALGTAINNAV 2024
Cdd:cd11684    236 QNEITdqWKERTILTTEESFPTILRRSEVVSIEEIELSPIENAIEDIEKKTEELRSLiNKYRSGDSPNVNPLQMLLQGTV 315

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376271640 2025 DSPVSERIKRYRELFIEGTYLDSHPEDcEEIQQLKTAIIQYVRAIQDSLEVHKRICRDV--AFYEILKNQLYKSFAEE 2100
Cdd:cd11684    316 DAAVNGGPVAYAEAFLSEEYLSNYPEA-EKVKKLKEAFEEFLEILKRGLALHAKLCPPEmaPLHEELEEGFEKLFKEL 392
DOCK-C2 pfam14429
C2 domain in Dock180 and Zizimin proteins; The Dock180/Dock1 and Zizimin proteins are atypical ...
 763-971 2.62e-45

C2 domain in Dock180 and Zizimin proteins; The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.


Pssm-ID: 464171  Cd Length: 185  Bit Score: 162.39  E-value: 2.62e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  763 PGHSRHDLYIKLCsasftsapssssgsmRLK-KNVSPGYNSDVQVTMEMRKADGTVVEDAImAGGSGEPGTSQWNSMVFH 841
Cdd:pfam14429    1 PGDYRNDLYVTPK---------------SGNfSKQKKSSARNIEVTVEVRDSDGEPLPNCI-YGGSGGPFVTEFKSTVYY 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  842 HNDKPVYDELVKIPLPVQLSE-YHLFLTFGSKSKNKQMtaDEAEKPFAFTYLPISTAN-IFVKDDDHELVLYHMDKnfqs 919
Cdd:pfam14429   65 HNKSPTWYEEIKIALPAELTPkHHLLFTFYHVSCDEKK--DKVEKPFGYAFLPLLDDDgAFLRDGEHTLPVYKYDE---- 138

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376271640  920 TPSLYFDAPhsakdWAHDPVLPDTILKGMSPLRDRVMIRTRLCSSVHTQDET 971
Cdd:pfam14429  139 LPPGYLSLP-----WSSGGEKESSALPGLKGGKDLFKVRTRLCSTKYTQDEH 185
C2_DOCK180_related cd08679
C2 domains found in Dedicator Of CytoKinesis 1 (DOCK 180) and related proteins; Dock180 was ...
 767-972 5.61e-44

C2 domains found in Dedicator Of CytoKinesis 1 (DOCK 180) and related proteins; Dock180 was first identified as an 180kd proto-oncogene product c-Crk-interacting protein involved in actin cytoskeletal changes. It is now known that it has Rac-specific GEF activity, but lacks the conventional Dbl homology (DH) domain. There are 10 additional related proteins that can be divided into four classes based on sequence similarity and domain organization: Dock-A which includes Dock180/Dock1, Dock2, and Dock5; Dock-B which includes Dock3/MOCA (modifier of cell adhesion) and Dock4; Dock-C which includes Dock6/Zir1, Dock7/Zir2, and Dock8/Zir3; and Dock-D, which includes Dock9/Zizimin1, Dock10/Zizimin3, and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Most of members of classes Dock-A and Dock-B are the GEFs specific for Rac. Those of Dock-D are Cdc42-specific GEFs while those of Dock-C are the GEFs for both. All Dock180-related proteins have two common homology domains: the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker). DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176061  Cd Length: 178  Bit Score: 158.26  E-value: 5.61e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  767 RHDLYIKLCsasftsapssssgsmRLKKNVSPGYNSDVQVTMEMRKADGTVVEDAIMAGGSGEPGTSQWNSMVFHHNdKP 846
Cdd:cd08679      2 RNDLYVYPQ---------------SGELSKAKSKGRNIEITVEVRDDDGDIIEPCISAPGSGSELRSEYTSVVYYHK-NP 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  847 VYDELVKIPLPVQLSE-YHLFLTFGSKSKNKQMTADEaEKPFAFTYLPISTAN-IFVKDDDHELVLYHMDKNFQSTPSLY 924
Cdd:cd08679     66 VFNDEIKIQLPADLTPqHHLLFTFYHVSSKKKQGDKE-ETPFGYAFLPLMDKDgAFIKDGDHTLPVYKYDKRPDVGPSGY 144

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1376271640  925 FDAPHSAKDWAHDPvlpdtilkgmsplrDRVMIRTRLCSSVHTQDETL 972
Cdd:cd08679    145 LSLPSTLANGKSSK--------------DTFKIKTRLCSTILTQDKSL 178
DHR-2_Lobe_C pfam20421
DHR-2, Lobe C; DOCK (dedicator of cytokinesis) proteins are guanine nucleotide exchange ...
 1991-2100 2.47e-03

DHR-2, Lobe C; DOCK (dedicator of cytokinesis) proteins are guanine nucleotide exchange factors (GEFs) that activate some small GTPases, such as Rac or Cdc42, by exchanging bound GDP for free GTP to control cell migration, morphogenesis, and phagocytosis. These proteins share a DOCK-type C2 domain (also termed the DOCK-homology region (DHR)-1) at the N-terminal, and the DHR-2 domain (also termed the DOCKER domain) at the C-terminal. DHR-2 is the GEF catalytic domain organized into three lobes A, B and C, with the Rho-family binding site and catalytic centre generated entirely from lobes B and C. This entry represents Lobe C which form an antiparallel four alpha-helical bundle and contains a loop known as the nucleotide sensor characterized by a conserved valine residue essential for catalytic activity.


Pssm-ID: 466570 [Multi-domain]  Cd Length: 103  Bit Score: 39.50  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1991 EIKAAIKSlqkssrgengRLPESKALGTAINNAVDSPVSERIKRYRELFIEGTYLDSHPEdcEEIQQLKTAIIQYVRAIQ 2070
Cdd:pfam20421    1 ELEAAINA----------PPPNIKTLQMVLQGSVDVQVNAGPLEYAEAFLSEKNVDNYPA--EKVEKLKEEFRDFLKVCG 68

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1376271640 2071 DSLEVHKRIC--RDVAFYEILKNQlYKSFAEE 2100
Cdd:pfam20421   69 EALRLNKKLIseDQREYQEELEEG-FEKLKEK 99
COG5099 COG5099
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ...
 2106-2268 2.49e-03

RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227430 [Multi-domain]  Cd Length: 777  Bit Score: 43.20  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2106 SSASSDDHFPSFP-SFAPDSSDHGKYYSSTKSQPSisiSFHRSSADRSFSDHREPNITSTMGSEGYNLPPL------RIG 2178
Cdd:COG5099     71 TSSSSSRRKPSGSwSVAISSSTSGSQSLLMELPSS---SFNPSTSSRNKSNSALSSTQQGNANSSVTLSSStassmfNSN 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2179 RLPSsggqPLTVHSAST----------HTHTPRESTSTTHNTPSTPVRAGITTPTSPPFR------TPSRTGSARKKDHR 2242
Cdd:COG5099    148 KLPL----PNPNHSNSAttnqsgssfiNTPASSSSQPLTNLVVSSIKRFPYLTSLSPFFNylidpsSDSATASADTSPSF 223

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1376271640 2243 --------RSLTSPLGPSELGHGKNRSVSSLSIR 2268
Cdd:COG5099    224 npppnlspNNLFSTSDLSPLPDTQSVENNIILNS 257
 
Name Accession Description Interval E-value
DOCK_N pfam16172
DOCK N-terminus; This family is found near to the N-terminus of dedicator of cytokinesis (DOCK) ...
 309-758 6.40e-95

DOCK N-terminus; This family is found near to the N-terminus of dedicator of cytokinesis (DOCK) proteins, between the variant SH3 domain (pfam07653) and the C2 domain (pfam14429).


Pssm-ID: 465040  Cd Length: 317  Bit Score: 310.21  E-value: 6.40e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  309 GDSTAGGQQWPLIDEIACAIREWYSRLPTYLANREYRLFNTVTQHIDALSLGRRQLLSQMLSGDELVRVRRECVSRLVKC 388
Cdd:pfam16172    2 GDETPTSAEEPLVDEIASCLREWHSTLHELLLSRQYQLFDKLSQLIYELDLARRQLLHGVLTADELKELREKTVWDLVRG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  389 NVAQGLDVIVRNLEDGSVVVVDRERAysgtkwvggISCYVYQVRLAYIDVipldnvfaevflTPQKAVFQSHTltsskge 468
Cdd:pfam16172   82 NKLLGLDVIVRDPTGRGRLLTDDDSV---------VELYKLQSEMSLLDE------------PPTPQVEPDAT------- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  469 lsdlpagSFYHLFLELRAFVANpcAPGETAELYFSLYNKADKRFISEEYCLILNHYGSPARDSEQrlGRIRTLFTDLKVE 548
Cdd:pfam16172  134 -------SLHHLLVDVKNFVGS--SIGEDAELFFSLYDKKELKFLSENFVVRLPSNGMPKSLAQS--LNLRTLFTDLSSS 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  549 DLA-PDTYLVCKIIRNgamkmrsddsmlpaslsasvagqrsslygisetglsghnqwrgdslmnltddsfsvtsaygpet 627
Cdd:pfam16172  203 DLArSKLYLVCKVIRN---------------------------------------------------------------- 218

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  628 hrpptttgttnapsstigggsgfggkvrVRRPLGWAVMLLPPMSKLMgdglDRDGGGVEQSVKIYVPREEKDFAGMFDDV 707
Cdd:pfam16172  219 ----------------------------VRRPFGVAVLDLTDILKGL----KQSDEEVEHVVPIWSPNNESDFDELHRDI 266

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1376271640  708 IHNRVKQYMDFSRAQSIVLYLKSLRGPAPQLVREHPSLLLDIPLTSRLSFP 758
Cdd:pfam16172  267 IKSITGKYEKSPRAERLWVSLKLFHGDAEQLRKENPTLLHNVAITRKLGFP 317
DHR2_DOCK cd11684
Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; DOCK proteins ...
 1709-2100 1.26e-79

Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; DOCK proteins comprise a family of atypical guanine nucleotide exchange factors (GEFs) that lack the conventional Dbl homology (DH) domain. As GEFs, they activate the small GTPases Rac and Cdc42 by exchanging bound GDP for free GTP. They are also called the CZH (CED-5, Dock180, and MBC-zizimin homology) family, after the first family members identified. Dock180 was first isolated as a binding partner for the adaptor protein Crk. The Caenorhabditis elegans protein, Ced-5, is essential for cell migration and phagocytosis, while the Drosophila ortholog, Myoblast city (MBC), is necessary for myoblast fusion and dorsal closure. DOCKs are divided into four classes (A-D) based on sequence similarity and domain architecture: class A includes Dock1 (or Dock180), 2 and 5; class B includes Dock3 and 4; class C includes Dock6, 7, and 8; and class D includes Dock9, 10 and 11. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1, and DHR-2 (also called CZH2 or Docker). This alignment model represents the DHR-2 domain of DOCK proteins, which contains the catalytic GEF activity for Rac and/or Cdc42.


Pssm-ID: 212566 [Multi-domain]  Cd Length: 392  Bit Score: 269.17  E-value: 1.26e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWkvgDEHWVDAGRWGDLELPAHSEFARKQAIYYHILGYLAQAEAHE 1788
Cdd:cd11684      2 LYIRYLHKLADLHEERGNYVEAALCLLLHADLYAW---DLKALVPALAESLSFPEQTSFERKEALYKKAIDLFDKGKAWE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1789 FSINLCQELITQHQRlTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGDIL-SLDKNKDYVIRAQVGQKYTDFC 1867
Cdd:cd11684     79 FAIALYKELIPQYEN-NFDYAKLSEVHRKIAKLYEKIAEKDRLFPTYFRVGFYGKGFpESLRGKEFIYRGPEFERLGDFC 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1868 DILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFgeNVSDNVQSYWRWNGIRRFSSVRPYLKDPGER 1947
Cdd:cd11684    158 ERLKSLYPGAEIIQSSEEPDDEILDSEGQYIQITSVEPYFDDEDLVS--RAAPGVRQFYRNNNINTFVYERPFTKGGKKS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1948 ETALA--WTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAIMEIKAAIKSLQKS-SRGENGRLPESKALGTAINNAV 2024
Cdd:cd11684    236 QNEITdqWKERTILTTEESFPTILRRSEVVSIEEIELSPIENAIEDIEKKTEELRSLiNKYRSGDSPNVNPLQMLLQGTV 315

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376271640 2025 DSPVSERIKRYRELFIEGTYLDSHPEDcEEIQQLKTAIIQYVRAIQDSLEVHKRICRDV--AFYEILKNQLYKSFAEE 2100
Cdd:cd11684    316 DAAVNGGPVAYAEAFLSEEYLSNYPEA-EKVKKLKEAFEEFLEILKRGLALHAKLCPPEmaPLHEELEEGFEKLFKEL 392
DHR2_DOCK_B cd11696
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis proteins; DOCK ...
 1709-2079 2.95e-52

Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis proteins; DOCK proteins are atypical guanine nucleotide exchange factors (GEFs) that lack the conventional Dbl homology (DH) domain. As GEFs, they activate small GTPases by exchanging bound GDP for free GTP. They are divided into four classes (A-D) based on sequence similarity and domain architecture; class B includes Dock3 and 4. Dock3 is a specific GEF for Rac and it regulates N-cadherin dependent cell-cell adhesion, cell polarity, and neuronal morphology. It promotes axonal growth by stimulating actin polymerization and microtubule assembly. Dock4 activates the Ras family GTPase Rap1, probably indirectly through interaction with Rap regulatory proteins. It plays a role in regulating dendritic growth and branching in hippocampal neurons, where it is highly expressed. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of class B DOCKs, which contains the catalytic GEF activity for Rac and/or Cdc42. Class B DOCKs also contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212569  Cd Length: 391  Bit Score: 189.96  E-value: 2.95e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWKvgdehwvDAGRWGDLELPAHSEFARKQAIYYHILGYLAQAEAHE 1788
Cdd:cd11696      2 MYLRYIYKLHDLHLQAENYTEAAFTLLLYAELLSWS-------SDPLPADLHHPSQPEWQRKEALYLKILQYFDRGKCWE 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1789 FSINLCQELITQHQRLtYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGDILSL-DKNKDYVIRAQVGQKYTDFC 1867
Cdd:cd11696     75 KGIPLCRELAELYESL-YDYAKLSHILRMEASFYDNILTQLRPEPEYFRVGFYGKGFPLfLRNKQFVYRGLDYERIGAFT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1868 DILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFGENVSDNVQSYWRWNGIRRFSSVRPYLKDPGER 1947
Cdd:cd11696    154 QRLQSEFPQAHILTKNTPPDDAILQADGQYIQICNVKPVPERRPVLQMVGVPDKVRSFYRVNDVRKFQYDRPIHKGPIDK 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1948 ETALA--WTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAIMEIKAAIKSL-----QKSSRGENGRLPESKALgtai 2020
Cdd:cd11696    234 DNEFKslWIERTTLVTEHSLPGILRWFEVVSREVEEIPPVENACETVENKNQELrslisQYQADPTRNINPFSMRL---- 309

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1376271640 2021 NNAVDSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVHKRI 2079
Cdd:cd11696    310 QGVIDAAVNGGIAKYQEAFFTPEFILSHPEDAEHIARLRELILEQVQILEAGLALHGKL 368
DHR2_DOCK_A cd11697
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis proteins; DOCK ...
 1709-2077 1.81e-50

Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis proteins; DOCK proteins are atypical guanine nucleotide exchange factors (GEFs) that lack the conventional Dbl homology (DH) domain. As GEFs, they activate small GTPases by exchanging bound GDP for free GTP. They are divided into four classes (A-D) based on sequence similarity and domain architecture; class A includes Dock1, 2 and 5. Class A DOCKs are specific GEFs for Rac. Dock1 interacts with the scaffold protein Elmo and the resulting complex functions upstream of Rac in many biological events including phagocytosis of apoptotic cells, cell migration and invasion. Dock2 plays an important role in lymphocyte migration and activation, T-cell differentiation, neutrophil chemotaxis, and type I interferon induction. Dock5 functions upstream of Rac1 to regulate osteoclast function. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of class A DOCKs, which contains the catalytic GEF activity for Rac and/or Cdc42. Class A DOCKs also contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212570  Cd Length: 400  Bit Score: 185.22  E-value: 1.81e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWKvgdehwvdagrwgDLELPAHSEFAR----------KQAIYYHIL 1778
Cdd:cd11697      2 MYIRYLYKLCDLHLECDNYTEAAYTLQLHAELLKWS-------------DEPLPTLLRSRRypeaqthrqlKEALYYDII 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1779 GYLAQAEAHEFSINLCQELITQHQRLTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGD-ILSLDKNKDYVIRA 1857
Cdd:cd11697     69 DYFDKGKMWECAISLCKELAEQYENETFDYLQLSELLKRMATFYDNIMKTLRPEPEYFRVGYYGQgFPSFLRNKVFIYRG 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1858 QVGQKYTDFCDILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFGENVSDNVQSYWRWNGIRRFSSV 1937
Cdd:cd11697    149 KEYERLSDFSARLLNQFPNAELMNTLTPPGDEIKESPGQYLQINKVDPVMDERPRFKGKPVSDQILNYYKVNEVQRFTFS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1938 RPYLK-DPGER-ETALAWTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAI--MEIK-AAIKSLQKSSRGENgRLPe 2012
Cdd:cd11697    229 RPFRRgTKDPDnEFANMWLERTTLTTAYKLPGILRWFEVVSTSTVEISPLENAIetMEDTnKKIRDLILQHQSDP-TLP- 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376271640 2013 SKALGTAINNAVDSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVHK 2077
Cdd:cd11697    307 INPLSMLLNGIVDAAVMGGIANYEKAFFTEEYLDEHPEDQELIERLKDLIAEQIPLLEAGLKIHK 371
DOCK-C2 pfam14429
C2 domain in Dock180 and Zizimin proteins; The Dock180/Dock1 and Zizimin proteins are atypical ...
 763-971 2.62e-45

C2 domain in Dock180 and Zizimin proteins; The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.


Pssm-ID: 464171  Cd Length: 185  Bit Score: 162.39  E-value: 2.62e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  763 PGHSRHDLYIKLCsasftsapssssgsmRLK-KNVSPGYNSDVQVTMEMRKADGTVVEDAImAGGSGEPGTSQWNSMVFH 841
Cdd:pfam14429    1 PGDYRNDLYVTPK---------------SGNfSKQKKSSARNIEVTVEVRDSDGEPLPNCI-YGGSGGPFVTEFKSTVYY 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  842 HNDKPVYDELVKIPLPVQLSE-YHLFLTFGSKSKNKQMtaDEAEKPFAFTYLPISTAN-IFVKDDDHELVLYHMDKnfqs 919
Cdd:pfam14429   65 HNKSPTWYEEIKIALPAELTPkHHLLFTFYHVSCDEKK--DKVEKPFGYAFLPLLDDDgAFLRDGEHTLPVYKYDE---- 138

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1376271640  920 TPSLYFDAPhsakdWAHDPVLPDTILKGMSPLRDRVMIRTRLCSSVHTQDET 971
Cdd:pfam14429  139 LPPGYLSLP-----WSSGGEKESSALPGLKGGKDLFKVRTRLCSTKYTQDEH 185
DHR2_DOCK1 cd11707
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1; Dock1, also ...
 1709-2076 4.34e-44

Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1; Dock1, also called Dock180, is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates small GTPases by exchanging bound GDP for free GTP. Dock1 interacts with the scaffold protein Elmo and the resulting complex functions upstream of Rac in many biological events including phagocytosis of apoptotic cells, cell migration and invasion. In the nervous system, it mediates attractive responses to netrin-1 and thus, plays a role in axon outgrowth and pathfinding. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class A includes Dock1, 2 and 5. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock1, which contains the catalytic GEF activity for Rac and/or Cdc42. Class A DOCKs, like Dock1, are specific GEFs for Rac and they contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212580  Cd Length: 400  Bit Score: 166.37  E-value: 4.34e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKW--KVGDEHWVDAGRWgdlelPAHSEFARKQAIYYHILGYLAQAEA 1786
Cdd:cd11707      2 MYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWseEACAAHLTQRDGY-----QATTQGQLKDQLYQEIIHYFDKGKM 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1787 HEFSINLCQELITQHQRLTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGD-ILSLDKNKDYVIRAQVGQKYTD 1865
Cdd:cd11707     77 WEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQgFPTFLRNKMFIYRGKEYERRED 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1866 FCDILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFGENVSDNVQSYWRWNGIRRFSSVRPYL---K 1942
Cdd:cd11707    157 FEARLLTQFPNAEKMKTTSPPGDDIKNSSGQYIQCFTVKPLLELPPKFQNKPVSEQIVSFYRVNEVQRFQYSRPVRkgeK 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1943 DPgERETALAWTEKTLLITKDELPGVLCRGEIVNIRYEQIAPI--AMAIMEIKAAIKSLQKSSRGENGRLPeSKALGTAI 2020
Cdd:cd11707    237 DP-DNEFANMWIERTTYVTAYKLPGILRWFEVKSVFMVEISPLenAIETMQLTNEKINNMVQQHLNDPNLP-INPLSMLL 314

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1376271640 2021 NNAVDSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVH 2076
Cdd:cd11707    315 NGIVDPAVMGGFANYEKAFFTEKYMQEHPEDHEKIEKLKDLIAWQIPFLAEGIRIH 370
C2_DOCK180_related cd08679
C2 domains found in Dedicator Of CytoKinesis 1 (DOCK 180) and related proteins; Dock180 was ...
 767-972 5.61e-44

C2 domains found in Dedicator Of CytoKinesis 1 (DOCK 180) and related proteins; Dock180 was first identified as an 180kd proto-oncogene product c-Crk-interacting protein involved in actin cytoskeletal changes. It is now known that it has Rac-specific GEF activity, but lacks the conventional Dbl homology (DH) domain. There are 10 additional related proteins that can be divided into four classes based on sequence similarity and domain organization: Dock-A which includes Dock180/Dock1, Dock2, and Dock5; Dock-B which includes Dock3/MOCA (modifier of cell adhesion) and Dock4; Dock-C which includes Dock6/Zir1, Dock7/Zir2, and Dock8/Zir3; and Dock-D, which includes Dock9/Zizimin1, Dock10/Zizimin3, and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Most of members of classes Dock-A and Dock-B are the GEFs specific for Rac. Those of Dock-D are Cdc42-specific GEFs while those of Dock-C are the GEFs for both. All Dock180-related proteins have two common homology domains: the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker). DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176061  Cd Length: 178  Bit Score: 158.26  E-value: 5.61e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  767 RHDLYIKLCsasftsapssssgsmRLKKNVSPGYNSDVQVTMEMRKADGTVVEDAIMAGGSGEPGTSQWNSMVFHHNdKP 846
Cdd:cd08679      2 RNDLYVYPQ---------------SGELSKAKSKGRNIEITVEVRDDDGDIIEPCISAPGSGSELRSEYTSVVYYHK-NP 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  847 VYDELVKIPLPVQLSE-YHLFLTFGSKSKNKQMTADEaEKPFAFTYLPISTAN-IFVKDDDHELVLYHMDKNFQSTPSLY 924
Cdd:cd08679     66 VFNDEIKIQLPADLTPqHHLLFTFYHVSSKKKQGDKE-ETPFGYAFLPLMDKDgAFIKDGDHTLPVYKYDKRPDVGPSGY 144

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1376271640  925 FDAPHSAKDWAHDPvlpdtilkgmsplrDRVMIRTRLCSSVHTQDETL 972
Cdd:cd08679    145 LSLPSTLANGKSSK--------------DTFKIKTRLCSTILTQDKSL 178
DHR2_DOCK2 cd11706
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2; Dock2 is a ...
 1690-2102 3.64e-43

Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2; Dock2 is a hematopoietic cell-specific, class A DOCK and is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates small GTPases by exchanging bound GDP for free GTP. It plays an important role in lymphocyte migration and activation, T-cell differentiation, neutrophil chemotaxis, and type I interferon induction. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class A includes Dock1, 2 and 5. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock2, which contains the catalytic GEF activity for Rac and/or Cdc42. Class A DOCKs, like Dock2, are specific GEFs for Rac and they contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212579  Cd Length: 421  Bit Score: 164.39  E-value: 3.64e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1690 RATAIYQLMNFVSAMGRKGLYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWKvgDEHwVDAGRWGDLELPAHSEFAR 1769
Cdd:cd11706      1 RMSCTVNLLNFYKDINREAMYIRYLYKLRDLHLDCENYTEAAYTLLLHTRLLKWS--DEQ-CASQVMQTGQQHPQTQRQL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1770 KQAIYYHILGYLAQAEAHEFSINLCQELITQHQRLTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGD-ILSLD 1848
Cdd:cd11706     78 KETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQgFPSFL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1849 KNKDYVIRAQVGQKYTDFCDILQTKYRQATIHRSKIPPPESIKRGtdPVIWIMPVTPEPDLTNPVFGEN--VSDNVQSYW 1926
Cdd:cd11706    158 RNKVFIYRGKEYERREDFQMQLMSQFPNAEKLNTTSAPGDDIKNS--PGQYIQCFTVQPVLEEHPRLKNkpVPDQIINFY 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1927 RWNGIRRFSSVRPYLKDP--GERETALAWTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAI--MEiKAAIKSLQKS 2002
Cdd:cd11706    236 KSNYVQRFHYSRPVRKGPvdPENEFASMWIERTTFVTAYKLPGILRWFEVTHMSQTTISPLENAIetMS-TTNEKILMMI 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2003 SRGENGRLPESKALGTAINNAVDSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVH-KRICR 2081
Cdd:cd11706    315 NQYQSDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTRLKDLIAWQIPLLGAGIKIHgKRVTD 394

                          410       420
                   ....*....|....*....|....*
gi 1376271640 2082 DV-AFYEILKN---QLYKSFAEEAG 2102
Cdd:cd11706    395 DLrPFHERMEEcfkQLKMKVEKEYG 419
DHR2_DOCK3 cd11704
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3; Dock3, also ...
 1709-2079 8.46e-42

Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3; Dock3, also called modifier of cell adhesion (MOCA), is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates small GTPases by exchanging bound GDP for free GTP. Dock3 is a specific GEF for Rac. It regulates N-cadherin dependent cell-cell adhesion, cell polarity, and neuronal morphology. It promotes axonal growth by stimulating actin polymerization and microtubule assembly. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class B includes Dock3 and 4. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock3, which contains the catalytic GEF activity for Rac and/or Cdc42. Class B DOCKs also contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212577  Cd Length: 392  Bit Score: 159.40  E-value: 8.46e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYkwkvgdeHWVDAGRWGDLELPAHSEFARKQAIYYHILGYLAQAEAHE 1788
Cdd:cd11704      2 MYIRYIHKLCDMHLQAENYTEAAFTLLLYCELL-------QWEDRPLREFLHYPSQSEWQRKEGLCRKIIHYFNKGKSWE 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1789 FSINLCQELITQHQRLtYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGDILSLD-KNKDYVIRAQVGQKYTDFC 1867
Cdd:cd11704     75 FGIPLCRELAFQYESL-YDYQSLSWIRKMEAAYYDNIMEQQRLEPEFFRVGFYGRKFPFFlRNKEYVCRGHDYERLEAFQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1868 DILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFGENVSDNVQSYWRWNGIRRFSSVRPYLKDPGER 1947
Cdd:cd11704    154 QRMLSEFPQAIAMQHPNHPDDGILQCDAQYLQIYAVTPIPDNMDVLQMDRVPDRIKSFYRVNNVRKFRYDRPFHKGPKDK 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1948 ETALA--WTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAI-------MEIKAAIKSLQKSSRGENGRLpeskaLGT 2018
Cdd:cd11704    234 ENEFKslWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIqvvenknQELRTLISQYQHKQLHGNINL-----LSM 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1376271640 2019 AINNAVDSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVHKRI 2079
Cdd:cd11704    309 CLNGVIDAAVNGGIARYQEAFFDKDYISKHPGDAEKITQLKELMQEQVHVLGVGLAVHEKF 369
DHR2_DOCK5 cd11708
Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5; Dock5 is an ...
 1709-2076 5.06e-38

Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5; Dock5 is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates small GTPases by exchanging bound GDP for free GTP. It functions upstream of Rac1 to regulate osteoclast function. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class A includes Dock1, 2 and 5. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock5, which contains the catalytic GEF activity for Rac and/or Cdc42. Class A DOCKs, like Dock5, are specific GEFs for Rac and they contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212581  Cd Length: 400  Bit Score: 148.55  E-value: 5.06e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWK---------VGDEHWVdagrWGDLELpahsefarKQAIYYHILG 1779
Cdd:cd11708      2 IYIRYLYKLRDLHLDCENYTEAAYTLLLHAELLQWSekpcvphllQRDSYYV----YTQQEL--------KERLYQEIIS 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1780 YLAQAEAHEFSINLCQELITQHQRLTYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGD-ILSLDKNKDYVIRAQ 1858
Cdd:cd11708     70 FFDKGKMWEKAIELSKELADMYENQVFDYEGLGNLLKKQAQFYENIMKAMRPQPEYFAVGYYGQgFPSFLRNKIFIYRGK 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1859 VGQKYTDFCDILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFGENVSDNVQSYWRWNGIRRFSSVR 1938
Cdd:cd11708    150 EYERLEDFSLKLLTQFPNAEKMTSTSPPGDEIKSSTKQYVQCFTVKPVMNLPSHYKDKPVPEQILNYYRANEVQQFQYSR 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1939 PYL---KDPgERETALAWTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAI--MEI-KAAIKSLQKSSRGENGrLPe 2012
Cdd:cd11708    230 PFRkgeKDP-DNEFATMWIERTTFTTAYRFPGILKWFEVKQISTEEISPLENAIetMELtNEKISNLVQQHAWDRS-LP- 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1376271640 2013 SKALGTAINNAVDSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVH 2076
Cdd:cd11708    307 VHPLSMLLNGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKIELLKQLIALQMPLLAEGIRIH 370
DHR2_DOCK4 cd11705
Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4; Dock4 is an ...
 1709-2078 6.03e-32

Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4; Dock4 is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates small GTPases by exchanging bound GDP for free GTP. It plays a role in regulating dendritic growth and branching in hippocampal neurons, where it is highly expressed. It may also regulate spine morphology and synapse formation. Dock4 activates the Ras family GTPase Rap1, probably indirectly through interaction with Rap regulatory proteins. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class B includes Dock3 and 4. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock4, which contains the catalytic GEF activity for Rac and/or Cdc42. Class B DOCKs also contain an SH3 domain at the N-terminal region and a PxxP motif at the C-terminus.


Pssm-ID: 212578  Cd Length: 391  Bit Score: 130.54  E-value: 6.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1709 LYVRYVHELVKNSKSVKNWLGAGLALKLHADIYKWKvgdehwvDAGRWGDLELPAHSEFARKQAIYYHILGYLAQAEAHE 1788
Cdd:cd11705      2 MYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWS-------DRPLREFLSYPMQTEWQRKEYLHLTIIQNFDRGKCWE 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1789 FSINLCQELITQHQRLtYDINMITELLGHQAKLWMTIGEAPRPKQEYFRVAYFGDILSLD-KNKDYVIRAQVGQKYTDFC 1867
Cdd:cd11705     75 NGIILCRKLAEQYESY-YDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFlRNKEFVCRGHDYERLEAFQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1868 DILQTKYRQATIHRSKIPPPESIKRGTDPVIWIMPVTPEPDLTNPVFGENVSDNVQSYWRWNGIRRFSSVRPYLKDPGER 1947
Cdd:cd11705    154 QRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQRDGVPDNIKSFYKVNHIWRFRYDRPFHKGTKDK 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1948 ETALA--WTEKTLLITKDELPGVLCRGEIVNIRYEQIAPIAMAIMEIKAAIKSLQK-SSRGENGRLPESKALGTAINNAV 2024
Cdd:cd11705    234 ENEFKslWVERTTLTLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTlISQCQTRQMQNINPLTMCLNGVI 313

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1376271640 2025 DSPVSERIKRYRELFIEGTYLDSHPEDCEEIQQLKTAIIQYVRAIQDSLEVHKR 2078
Cdd:cd11705    314 DAAVNGGVSRYQEAFFVKEYILNHPEDGDKITRLRELMLEQAQILEFGLAVHEK 367
C2_Dock-A cd08694
C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins; Dock-A is one of 4 ...
 803-969 2.10e-20

C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins; Dock-A is one of 4 classes of Dock family proteins. The members here include: Dock180/Dock1, Dock2, and Dock5. Most of these members have been shown to be GEFs specific for Rac. Dock5 has not been well characterized to date, but most likely also is a GEF specific for Rac. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-A members contain a proline-rich region and a SH3 domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176076  Cd Length: 196  Bit Score: 91.31  E-value: 2.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  803 DVQVTMEMRKADGTVVEDAImAGGSGEPGTSQWNSMVFHHNDKPVYDELVKIPLPV-QLSEYHLFLTFGSKSKNKQmtAD 881
Cdd:cd08694     24 NVEVTVSVCNEDGKIIPGVI-SLGAGEEPIDEYKSVIYYQVDKPKWFETFKVAIPIeDFKSSHLRFTFKHRSSNEA--KD 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  882 EAEKPFAFTYLPISTAN-IFVKDDDHELVLYHMD-KNFQSTPSLYFDAPHS---AKDWAHDPVLPDTILKGMSPLRDRVM 956
Cdd:cd08694    101 KSEKPFALSFVKLMQENgTTLTDGEHDLIVYKVDaKKKLEDAKAYLSLPSTraeLEARKSSPSGSASNLGLSLSSKDSFQ 180

                          170
                   ....*....|...
gi 1376271640  957 IRTRLCSSVHTQD 969
Cdd:cd08694    181 ISTLVCSTKLTQN 193
C2_Dock-B cd08695
C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins; Dock-B is one of 4 ...
 803-969 1.60e-18

C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins; Dock-B is one of 4 classes of Dock family proteins. The members here include: Dock3/MOCA (modifier of cell adhesion) and Dock4. Most of these members have been shown to be GEFs specific for Rac, although Dock4 has also been shown to interact indirectly with the Ras family GTPase Rap1, probably through Rap regulatory proteins. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-B members contain a SH3 domain upstream of the C2 domain and a proline-rich region downstream. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176077  Cd Length: 189  Bit Score: 85.51  E-value: 1.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  803 DVQVTMEMRKADGTVVEDAImAGGSGEPGTSQWNSMVFHHNDKPVYDELVKIPLPV-QLSEYHLFLTFGSKSknkqmTAD 881
Cdd:cd08695     24 NIEVTMVVLDADGQVLKDCI-SLGSGEPPCSEYRSFVLYHNNSPRWNETIKLPIPIdKFRGSHLRFEFRHCS-----TKD 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  882 EAEKP-FAFTYLPI-STANIFVKDDDHELVLYHMDKN--FQStPSLYFDAPHSAKDWAHDPVLPDTILkGMSPlRDRVMI 957
Cdd:cd08695     98 KGEKKlFGFSFVPLmREDGTTLPDGSHELYVYKCDENatFLD-PALYLGLPCSKEDFQGCPNSPSPLF-SRSS-KESFWI 174

                          170
                   ....*....|..
gi 1376271640  958 RTRLCSSVHTQD 969
Cdd:cd08695    175 RTLLCSTKLTQN 186
C2_Dock-D cd08697
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; Dock-D is one of 4 ...
 806-972 4.10e-10

C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; Dock-D is one of 4 classes of Dock family proteins. The members here include: Dock9/Zizimin1, Dock10/Zizimin3, and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Dock-D are Cdc42-specific GEFs. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-D members contain a functionally uncharacterized domain and a PH domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The PH domain broadly binds to phospholipids and is thought to be involved in targeting the plasma membrane. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176079  Cd Length: 185  Bit Score: 61.18  E-value: 4.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  806 VTMEMRKADGtvvEDA----IMAGGSGEPGTSQWNSMVFHHNDKPV-YDElVKIPLPVQL-SEYHLFLTF-------GSK 872
Cdd:cd08697     28 VCIEFRDSDE---EDAkplkCIYYGPGGGFTTSAYAAVLHHNQNPEfYDE-IKIELPTQLhEKHHLLFTFyhvscdiNKK 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  873 SKNKqmtaDEAEKPFAFTYLPISTANIFVKDDDHELVLY-HMDKNFQSTPSLYFDAPHSAKDWAHDPvlpdtILKgmspl 951
Cdd:cd08697    104 GKKK----DGVETPVGYAWLPLLKDKGRLNSEEQTPPVAnLLPNYPDGYLSIQPHGPEVKWVDGGKP-----LFK----- 169

                          170       180
                   ....*....|....*....|.
gi 1376271640  952 rdrvmIRTRLCSSVHTQDETL 972
Cdd:cd08697    170 -----VSTHLVSTVYTQDQHL 185
C2_Dock-C cd08696
C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; Dock-C is one of 4 ...
 839-972 5.41e-07

C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins; Dock-C is one of 4 classes of Dock family proteins. The members here include: Dock6/Zir1, Dock7/Zir2, and Dock8/Zir3. Dock-C members are GEFs for both Rac and Cdc42. In addition to the C2 domain (AKA Dock homology region (DHR)-1, CED-5, Dock180, MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2, or Docker), which all Dock180-related proteins have, Dock-C members contain a functionally uncharacterized domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176078  Cd Length: 179  Bit Score: 51.97  E-value: 5.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640  839 VFHHNDKP-VYDElVKIPLPVQLSE-YHLFLTFGSKSKNKQMTADEAEKPFAFTYLPIsTANIFVKDDDHELvLYHMDKN 916
Cdd:cd08696     60 VTYHNKSPdFYDE-IKIKLPADLTDnHHLLFTFYHISCQKKQEGGSVETPIGYTWLPL-LRNGRLQSGEFNL-PVSLEKP 136

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1376271640  917 fqstPSLYfdAPHSakdwahdpvlPDTILKGMSPL---RDRVMIRTRLCSSVHTQDETL 972
Cdd:cd08696    137 ----PSNY--SPDS----------PEVKLPGTKWVdnhKGVFSVSVEAVSSVHTQDSYL 179
DHR2_DOCK_D cd11694
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis proteins; DOCK ...
 1835-2100 9.97e-07

Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis proteins; DOCK proteins are atypical guanine nucleotide exchange factors (GEFs) that lack the conventional Dbl homology (DH) domain. As GEFs, they activate small GTPases by exchanging bound GDP for free GTP. They are divided into four classes (A-D) based on sequence similarity and domain architecture; class D, also called the Zizimin subfamily, includes Dock9, 10 and 11. Class D Docks are specific GEFs for Cdc42. Dock9 plays important roles in spine formation and dendritic growth. Dock10 and Dock11 are preferentially expressed in lymphocytes. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of class D DOCKs, which contains the catalytic GEF activity for Cdc42. Class D DOCKs also contain a Pleckstrin homology (PH) domain at the N-terminus.


Pssm-ID: 212567  Cd Length: 376  Bit Score: 53.50  E-value: 9.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1835 YFRVAYFGDI-LSLDKNKDYVIRAqvgQKYTDFCDI---LQTKYrqatihrskipppeSIKRGTDPVIWIM---PVTPEp 1907
Cdd:cd11694    112 YYRVAFYGQAfFEEEDGKEYIYKE---PKVTSLSEIserLLKLY--------------GDKFGSENVKLIQdsgKVNPK- 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1908 DL-----------TNPVFGEN-VSDNVQSYWRWNGIRRFSSVRPYLKDpGERETALA--WTEKTLLITKDELPGVLCRGE 1973
Cdd:cd11694    174 DLdpkyayiqvthVTPYFDEKeLEDRKTEFERNHNIRRFVFETPFTLS-GKARGAVEeqWKRRTILTTSHSFPYVKKRIP 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1974 IVNIRYEQIAPIAMAIMEIKAAIKSLQKSSRGENgrlPESKALGTAINNAVDSPVSERIKRYRELFIEGTYLDSHPEDce 2053
Cdd:cd11694    253 VVQREIIELSPIEVAIDEMQSKVKELEELISTEP---VDMKKLQLRLQGSVSVQVNAGPLAYARAFLEPTTVKNYPDD-- 327

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1376271640 2054 EIQQLKTAIIQYVRAIQDSLEVHKRICRD--VAFYEILKNQlYKSFAEE 2100
Cdd:cd11694    328 QVEDLKDVFRDFIKACGQALELNERLIKEdqREYHEVLKEN-YRKMVKE 375
DHR2_DOCK9 cd11698
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9; Dock9, also ...
 1835-2100 6.90e-05

Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9; Dock9, also called Zizimin1, is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates the small GTPase Cdc42 by exchanging bound GDP for free GTP. It plays important roles in spine formation and dendritic growth. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class D includes Dock9, 10 and 11. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock9, which contains the catalytic GEF activity for Cdc42. Class D DOCKs also contain a Pleckstrin homology (PH) domain at the N-terminus.


Pssm-ID: 212571  Cd Length: 415  Bit Score: 47.72  E-value: 6.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1835 YFRVAYFGDILSLDKN-KDYVIRAQvgqKYTDFCDILQ-------TKYRQATIH----RSKIPPPE-SIKRGTDPVIWIM 1901
Cdd:cd11698    148 YFRVAFFGQGFFEDEDgKEYIYKEP---KLTPLSEISQrllklysDKFGSENVKmiqdSGKVNPKDlDSKYAYIQVTHVT 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1902 PVTPEPDLtnpvfgenvSDNVQSYWRWNGIRRFSSVRPYLKDpGERETAL--AWTEKTLLITKDELPGVLCRGEIVNIRY 1979
Cdd:cd11698    225 PYFDEKEL---------QERKTDFERSHNIRRFMFEMPFTQS-GKRQGGVeeQCKRRTILTAIHCFPYVKKRIPVMYQHH 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1980 EQIAPIAMAIMEIKAAIKSL-QKSSRGENGRLPESKALGTAINNAVDS-PVSerikrYRELFIEGTYLDSHPEDceEIQQ 2057
Cdd:cd11698    295 TDLNPIEVAIDEMSKKVAELrQLCSSAEVDMIKLQLKLQGSVSVQVNAgPLA-----YARAFLDDTNTKRYPDN--KVKL 367

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1376271640 2058 LKTAIIQYVRAIQDSLEVHKRICRD--VAFYEILKNQlYKSFAEE 2100
Cdd:cd11698    368 LKEVFRQFVEACGQALAVNERLIKEdqLEYQEEMKAN-YREMAKE 411
DHR2_DOCK11 cd11700
Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11; Dock11, also ...
 1814-2100 3.27e-04

Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11; Dock11, also called Zizimin2 or activated Cdc42-associated GEF (ACG), is an atypical guanine nucleotide exchange factor (GEF) that lacks the conventional Dbl homology (DH) domain. As a GEF, it activates the small GTPase Cdc42 by exchanging bound GDP for free GTP. Dock11 is predominantly expressed in lymphocytes and is found in high levels in germinal center B lymphocytes after T cell dependent antigen immunization. DOCK proteins are divided into four classes (A-D) based on sequence similarity and domain architecture; class D includes Dock9, 10 and 11. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker). The DHR-1 domain binds phosphatidylinositol-3,4,5-triphosphate. This alignment model represents the DHR-2 domain of Dock11, which contains the catalytic GEF activity for Cdc42. Class D DOCKs also contain a Pleckstrin homology (PH) domain at the N-terminus.


Pssm-ID: 212573  Cd Length: 413  Bit Score: 45.76  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1814 LLGHQAKLWMTIGEAPRPKQEYFRVAYFGD-ILSLDKNKDYVIRAQvgqKYTDFCDIlqtKYRQATIHRSKIPPpESIK- 1891
Cdd:cd11700    128 LHGAYAKILEVMHTGKRLLGTFFRVAFYGQgFFEEEDGKEYIYKEP---KLTGLSEI---SHRLLKLYGEKFGS-ENVKi 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1892 ---------RGTDPVIWIMPVTpepdLTNPVFGEN-VSDNVQSYWRWNGIRRFSSVRPYL---KDPGERETALawTEKTL 1958
Cdd:cd11700    201 iqdsnkvnqKDLDPKYAHIQVT----YVKPYFDDKeMAERKTEFERNHNIQRFVFETPYTlsgKKQGGVEEQC--KRRTI 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1959 LITKDELPGVLCRGEIVNIRYEQIAPIAMAIMEIKAAIKSLQK-SSRGENGRLpeskALGTAINNAVDSPVSERIKRYRE 2037
Cdd:cd11700    275 LTTANSFPYVKKRIPVNGEKQTNLKPIDVATDEIKDKTAELQKlCSNQDVDMI----QLQLKLQGCVSVQVNAGPLAYAR 350

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1376271640 2038 LFIEGTYLDSHPEdcEEIQQLKTAIIQYVRAIQDSLEVHKRICRD--VAFYEILKNQlYKSFAEE 2100
Cdd:cd11700    351 AFLDDSQASKYPN--KKVKELKEMFRKFIQACSIALELNERLIKEdqVEYHEGLKSN-FRDMVKE 412
DHR-2_Lobe_C pfam20421
DHR-2, Lobe C; DOCK (dedicator of cytokinesis) proteins are guanine nucleotide exchange ...
 1991-2100 2.47e-03

DHR-2, Lobe C; DOCK (dedicator of cytokinesis) proteins are guanine nucleotide exchange factors (GEFs) that activate some small GTPases, such as Rac or Cdc42, by exchanging bound GDP for free GTP to control cell migration, morphogenesis, and phagocytosis. These proteins share a DOCK-type C2 domain (also termed the DOCK-homology region (DHR)-1) at the N-terminal, and the DHR-2 domain (also termed the DOCKER domain) at the C-terminal. DHR-2 is the GEF catalytic domain organized into three lobes A, B and C, with the Rho-family binding site and catalytic centre generated entirely from lobes B and C. This entry represents Lobe C which form an antiparallel four alpha-helical bundle and contains a loop known as the nucleotide sensor characterized by a conserved valine residue essential for catalytic activity.


Pssm-ID: 466570 [Multi-domain]  Cd Length: 103  Bit Score: 39.50  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 1991 EIKAAIKSlqkssrgengRLPESKALGTAINNAVDSPVSERIKRYRELFIEGTYLDSHPEdcEEIQQLKTAIIQYVRAIQ 2070
Cdd:pfam20421    1 ELEAAINA----------PPPNIKTLQMVLQGSVDVQVNAGPLEYAEAFLSEKNVDNYPA--EKVEKLKEEFRDFLKVCG 68

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1376271640 2071 DSLEVHKRIC--RDVAFYEILKNQlYKSFAEE 2100
Cdd:pfam20421   69 EALRLNKKLIseDQREYQEELEEG-FEKLKEK 99
COG5099 COG5099
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ...
 2106-2268 2.49e-03

RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227430 [Multi-domain]  Cd Length: 777  Bit Score: 43.20  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2106 SSASSDDHFPSFP-SFAPDSSDHGKYYSSTKSQPSisiSFHRSSADRSFSDHREPNITSTMGSEGYNLPPL------RIG 2178
Cdd:COG5099     71 TSSSSSRRKPSGSwSVAISSSTSGSQSLLMELPSS---SFNPSTSSRNKSNSALSSTQQGNANSSVTLSSStassmfNSN 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376271640 2179 RLPSsggqPLTVHSAST----------HTHTPRESTSTTHNTPSTPVRAGITTPTSPPFR------TPSRTGSARKKDHR 2242
Cdd:COG5099    148 KLPL----PNPNHSNSAttnqsgssfiNTPASSSSQPLTNLVVSSIKRFPYLTSLSPFFNylidpsSDSATASADTSPSF 223

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1376271640 2243 --------RSLTSPLGPSELGHGKNRSVSSLSIR 2268
Cdd:COG5099    224 npppnlspNNLFSTSDLSPLPDTQSVENNIILNS 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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