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Conserved domains on  [gi|1370487548|ref|XP_024309981|]
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protein NDNF isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 394-568 1.42e-110

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


:

Pssm-ID: 466079  Cd Length: 174  Bit Score: 327.39  E-value: 1.42e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 394 KLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQ 473
Cdd:pfam19433   1 KVLTSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDKLRTCNSVTVAWLGTQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 474 ERNKFCIYKKEVDDNYNEDqKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGH 553
Cdd:pfam19433  81 ERSKYCLYKKEVEEDQVER-ESRKQNRCLGPESRKKSEKVLCKYFHGANLQRAVTTETIEGLEPGTLYLLDVYVIGQGGH 159

                         170
                  ....*....|....*
gi 1370487548 554 SVKYQSKVVKTRKFC 568
Cdd:pfam19433 160 SVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 192-335 3.32e-47

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


:

Pssm-ID: 462981  Cd Length: 127  Bit Score: 161.07  E-value: 3.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 192 VTLAWKPSPTAsLLKQPIQYCVVINKEHNFKSLCAVEAKLsaDDAFMmapkPGLDFSPFDFAHFGFPSDNSG-KERSFQA 270
Cdd:pfam10179   1 VTLKWKPSPSV-LDRHPMHYCLVVNRKHNYKSLCAAVEAI--RKEQP----PGKTSKSFDPASFEFLKERWPqKERKLNP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487548 271 KPSpklgrhvysrpKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTK 335
Cdd:pfam10179  74 RVS-----------SGDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
 
Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 394-568 1.42e-110

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 327.39  E-value: 1.42e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 394 KLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQ 473
Cdd:pfam19433   1 KVLTSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDKLRTCNSVTVAWLGTQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 474 ERNKFCIYKKEVDDNYNEDqKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGH 553
Cdd:pfam19433  81 ERSKYCLYKKEVEEDQVER-ESRKQNRCLGPESRKKSEKVLCKYFHGANLQRAVTTETIEGLEPGTLYLLDVYVIGQGGH 159

                         170
                  ....*....|....*
gi 1370487548 554 SVKYQSKVVKTRKFC 568
Cdd:pfam19433 160 SVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 192-335 3.32e-47

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 161.07  E-value: 3.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 192 VTLAWKPSPTAsLLKQPIQYCVVINKEHNFKSLCAVEAKLsaDDAFMmapkPGLDFSPFDFAHFGFPSDNSG-KERSFQA 270
Cdd:pfam10179   1 VTLKWKPSPSV-LDRHPMHYCLVVNRKHNYKSLCAAVEAI--RKEQP----PGKTSKSFDPASFEFLKERWPqKERKLNP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487548 271 KPSpklgrhvysrpKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTK 335
Cdd:pfam10179  74 RVS-----------SGDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
 
Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 394-568 1.42e-110

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 327.39  E-value: 1.42e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 394 KLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQ 473
Cdd:pfam19433   1 KVLTSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDKLRTCNSVTVAWLGTQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 474 ERNKFCIYKKEVDDNYNEDqKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGH 553
Cdd:pfam19433  81 ERSKYCLYKKEVEEDQVER-ESRKQNRCLGPESRKKSEKVLCKYFHGANLQRAVTTETIEGLEPGTLYLLDVYVIGQGGH 159

                         170
                  ....*....|....*
gi 1370487548 554 SVKYQSKVVKTRKFC 568
Cdd:pfam19433 160 SVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 192-335 3.32e-47

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 161.07  E-value: 3.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 192 VTLAWKPSPTAsLLKQPIQYCVVINKEHNFKSLCAVEAKLsaDDAFMmapkPGLDFSPFDFAHFGFPSDNSG-KERSFQA 270
Cdd:pfam10179   1 VTLKWKPSPSV-LDRHPMHYCLVVNRKHNYKSLCAAVEAI--RKEQP----PGKTSKSFDPASFEFLKERWPqKERKLNP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487548 271 KPSpklgrhvysrpKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTK 335
Cdd:pfam10179  74 RVS-----------SGDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 133-335 2.10e-09

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 56.98  E-value: 2.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 133 VEYFISSSSPSGLYQLDLLSTEK-DTHFKVYATTTPeSDQPYPELPYDPRVDVTSLGRT--TVTLAWKPSptasllKQPI 209
Cdd:pfam19433  11 LRHFQLRGKPKAEYLVRLKSGRKgNSSLKVFATTNP-HKQPFPSLPEDTKIKVFDKLRTcnSVTVAWLGT------QERS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487548 210 QYCVVINKEHnfkslcaveaklsaddafmmaPKPGLDFSPFDFAHFGfPSDNSGKERSfqakpspkLGRHVYSrpkVDIQ 289
Cdd:pfam19433  84 KYCLYKKEVE---------------------EDQVERESRKQNRCLG-PESRKKSEKV--------LCKYFHG---ANLQ 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370487548 290 KICIgnknIFTVSDLKPDTQYYFDVFVVNiNSNMSTAYVGTFARTK 335
Cdd:pfam19433 131 RAVT----TETIEGLEPGTLYLLDVYVIG-QGGHSVKYQSKVVKTR 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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