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Conserved domains on  [gi|1370487493|ref|XP_024309964|]
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toll-like receptor 1 isoform X1 [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 1.88e-40

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.16  E-value: 1.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487493  714 AHHNLFHEGSNSLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
215-526 2.77e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 215 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDY 294
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 295 SGTSLKALSIHQVVSDVFgFPQSYIYEIFSNMNIKNFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHL 371
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 372 TELETLILQMNQLKELSKIAEmttQMKSLQQLDISQNSVSYdekkgdcswtksllslnmssniLTDTIFRClpPRIKVLD 451
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD----------------------LPEPLGNL--TNLEELD 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487493 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 526
Cdd:COG4886   212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.15e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  29 VDRSKNGLIHVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLV 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370487493 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 4.92e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370487493  524 NPFQCTCELGEFVKNIDQvssEVLEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 1.88e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.16  E-value: 1.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487493  714 AHHNLFHEGSNSLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 2.61e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 100.13  E-value: 2.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 716 HNLFHEGSNsLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWP------------KEKSKRGLFWANLRAAIN 777
Cdd:pfam01582  81 ECALDLGQK-VIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAYDIS 159


                  ....
gi 1370487493 778 IKLT 781
Cdd:pfam01582 160 NKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
215-526 2.77e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 215 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDY 294
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 295 SGTSLKALSIHQVVSDVFgFPQSYIYEIFSNMNIKNFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHL 371
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 372 TELETLILQMNQLKELSKIAEmttQMKSLQQLDISQNSVSYdekkgdcswtksllslnmssniLTDTIFRClpPRIKVLD 451
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD----------------------LPEPLGNL--TNLEELD 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487493 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 526
Cdd:COG4886   212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.15e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  29 VDRSKNGLIHVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLV 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370487493 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 3.04e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370487493 507 ADFFQSCQKMRSIKAGDNPFqcTCEL-GEFVK----NIDQVSSEVLEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
69-126 3.54e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370487493  69 SKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 4.92e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370487493  524 NPFQCTCELGEFVKNIDQvssEVLEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 9.32e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 9.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370487493 423 KSLLSLNMSSNILTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.22e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  33 KNGLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRIQYLDISVfkfNQELEYLDLSHNKLVKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1370487493 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.49e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 36.65  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1370487493 553 SYKCDYPESYRGTLLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
LRR_8 pfam13855
Leucine rich repeat;
445-500 1.57e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 2.49e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370487493  43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRIQYLD--ISVFKFNQELEYLDLSHNKLVKIS 109
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 1.88e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.16  E-value: 1.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370487493  714 AHHNLFHEGSNSLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 2.61e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 100.13  E-value: 2.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 716 HNLFHEGSNsLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWP------------KEKSKRGLFWANLRAAIN 777
Cdd:pfam01582  81 ECALDLGQK-VIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAYDIS 159


                  ....
gi 1370487493 778 IKLT 781
Cdd:pfam01582 160 NKLN 163
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 640-733 1.54e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 1.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 640 FISYSGHDSFWVKnELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 719
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 1370487493 720 HEGSNSLILILLEP 733
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
215-526 2.77e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 215 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDY 294
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 295 SGTSLKALSIHQVVSDVFgFPQSYIYEIFSNMNIKNFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHL 371
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 372 TELETLILQMNQLKELSKIAEmttQMKSLQQLDISQNSVSYdekkgdcswtksllslnmssniLTDTIFRClpPRIKVLD 451
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD----------------------LPEPLGNL--TNLEELD 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370487493 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 526
Cdd:COG4886   212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.15e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  29 VDRSKNGLIHVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLV 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370487493 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 1.72e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  32 SKNGLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLVKIs 109
Cdd:COG4886   167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEG 183
Cdd:COG4886   244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 184 LQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIR 263
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                         250
                  ....*....|
gi 1370487493 264 ILQLVWHTTV 273
Cdd:COG4886   402 LLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 3.04e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370487493 507 ADFFQSCQKMRSIKAGDNPFqcTCEL-GEFVK----NIDQVSSEVLEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
69-126 3.54e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370487493  69 SKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 4.92e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370487493  524 NPFQCTCELGEFVKNIDQvssEVLEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 9.32e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 9.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370487493 423 KSLLSLNMSSNILTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
LRR_8 pfam13855
Leucine rich repeat;
48-105 2.93e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.93e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370487493  48 TILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 273-536 2.93e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 273 VWYFSISNVKLQGQLDFRDFDYsgTSLKALSIhqVVSDVFG-FPQSyiyeiFSNMNIKNftvsgtrmvhmlcpskispfl 351
Cdd:PLN00113  430 VYFLDISNNNLQGRINSRKWDM--PSLQMLSL--ARNKFFGgLPDS-----FGSKRLEN--------------------- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 352 hLDFSNNLLTDTVFENCGHLTEletlilqmnqlkelskiaemttqmksLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  480 -LDLSRNQFSGAVPRKLGSLSE--------------------------LMQLKLSENKLS-GEIPDELSSCKKLVSLDLS 531

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSL-TDLPGCGSFSSLSVLIIDHNSV--SHP 505
Cdd:PLN00113  532 HNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVAGNIDlcGGD 611

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1370487493 506 SADFFQSCQKMRsiKAGDNPFQCTCELGEFV 536
Cdd:PLN00113  612 TTSGLPPCKRVR--KTPSWWFYITCTLGAFL 640
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 6.60e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493   2 TSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELwTSDILSLSKLRILIISHNRI 81
Cdd:COG4886    30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG-LTDLGDLTNLTELDLSGNEE 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370487493  82 qyldisvFKFNQELEYLDLSHNKLVKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   109 -------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
344-484 1.00e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 344 PSKISPFLhLDfSNNLLT---------DTVFENCGHLTELETLILQMNQLKELS--KIAEMTTQMKS-LQQLDISQNSVS 411
Cdd:PRK15370  198 PEQITTLI-LD-NNELKSlpenlqgniKTLYANSNQLTSIPATLPDTIQEMELSinRITELPERLPSaLQSLDLFHNKIS 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 412 ---------------YDE--KKGDCSWTKSLLSLNMSSNILT----------------DTIFRCLP----PRIKVLDLHS 454
Cdd:PRK15370  276 clpenlpeelrylsvYDNsiRTLPAHLPSGITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSK 355

                         170       180       190
                  ....*....|....*....|....*....|
gi 1370487493 455 NKIKSIPKQVVKleALQELNVAFNSLTDLP 484
Cdd:PRK15370  356 NQITVLPETLPP--TITTLDVSRNALTNLP 383
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.22e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  33 KNGLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRIQYLDISVfkfNQELEYLDLSHNKLVKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1370487493 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-526 2.92e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 351 LHLdFSNNLltdTVFENCGHLTELETLILQMNQLKELskiaEMTTQMKSLQQLDISQNSVSYDEKKGDCSwtkSLLSLNM 430
Cdd:cd21340    29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKI----ENLENLVNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 431 SSNiltdtifrCLPPRIKVL-DLHSnkIKSIpkqvvkLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPS--A 507
Cdd:cd21340    98 ENQ--------RLPPGEKLTfDPRS--LAAL------SNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelL 161

                         170
                  ....*....|....*....
gi 1370487493 508 DFFQSCQKMRSIKAGDNPF 526
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPV 180
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.49e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 36.65  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1370487493 553 SYKCDYPESYRGTLLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
LRR_8 pfam13855
Leucine rich repeat;
445-500 1.57e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 2.49e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370487493  43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRIQYLD--ISVFKFNQELEYLDLSHNKLVKIS 109
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-411 2.61e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493 352 HLDFSNNLLTDTvfENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-147 7.54e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 7.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370487493  48 TILNISQNYISELwtSDILSLSKLRILIISHNRI------------QYLDIS--------VFKFNQE--------LEYLD 99
Cdd:cd21340    49 THLYLQNNQIEKI--ENLENLVNLKKLYLGGNRIsvveglenltnlEELHIEnqrlppgeKLTFDPRslaalsnsLRVLN 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370487493 100 LSHNKLVKISC-HPTVNLKHLDLSFNAFDAL-PICKEFGNMSQLKFLGLS 147
Cdd:cd21340   127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLT 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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