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Conserved domains on  [gi|1370475531|ref|XP_024307381|]
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homeobox protein Meis3 isoform X2 [Homo sapiens]

Protein Classification

Meis_PKNOX_N and homeodomain domain-containing protein( domain architecture ID 11071485)

Meis_PKNOX_N and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Meis_PKNOX_N super family cl24908
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 184-251 1.06e-35

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


The actual alignment was detected with superfamily member pfam16493:

Pssm-ID: 465140  Cd Length: 86  Bit Score: 127.46  E-value: 1.06e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475531 184 GGDVCSSDSFNEDIAAFAKQV-RSERPLFSSNPELDNLMIQAIQVLRFHLLELEK-----------------GKMPIDLV 245
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIeRAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKvhelcdnfchryitclkGKMPSDLV 80


                  ....*.
gi 1370475531 246 IEDRDG 251
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 402-436 4.66e-18

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 77.17  E-value: 4.66e-18
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1370475531 402 LQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:pfam05920   5 LHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 184-251 1.06e-35

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 127.46  E-value: 1.06e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475531 184 GGDVCSSDSFNEDIAAFAKQV-RSERPLFSSNPELDNLMIQAIQVLRFHLLELEK-----------------GKMPIDLV 245
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIeRAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKvhelcdnfchryitclkGKMPSDLV 80


                  ....*.
gi 1370475531 246 IEDRDG 251
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 402-436 4.66e-18

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 77.17  E-value: 4.66e-18
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1370475531 402 LQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:pfam05920   5 LHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 400-436 5.51e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 60.72  E-value: 5.51e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475531 400 WWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:cd00086    18 EFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 400-436 4.10e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 4.10e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1370475531  400 WWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:smart00389  19 EFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 184-251 1.06e-35

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 127.46  E-value: 1.06e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475531 184 GGDVCSSDSFNEDIAAFAKQV-RSERPLFSSNPELDNLMIQAIQVLRFHLLELEK-----------------GKMPIDLV 245
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIeRAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKvhelcdnfchryitclkGKMPSDLV 80


                  ....*.
gi 1370475531 246 IEDRDG 251
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 402-436 4.66e-18

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 77.17  E-value: 4.66e-18
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1370475531 402 LQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:pfam05920   5 LHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 400-436 5.51e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 60.72  E-value: 5.51e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475531 400 WWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:cd00086    18 EFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 400-436 4.10e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 4.10e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1370475531  400 WWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:smart00389  19 EFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
Homeodomain pfam00046
Homeodomain;
403-436 7.68e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.26  E-value: 7.68e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1370475531 403 QHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 436
Cdd:pfam00046  21 ENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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