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Conserved domains on  [gi|1370472353|ref|XP_024306733|]
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dynein regulatory complex subunit 3 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-188 1.61e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 92.93  E-value: 1.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  54 NILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISK-------IDS 126
Cdd:cd21340    35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdPRS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370472353 127 LDALVK-LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDykmfICAYLPDLMYL 188
Cdd:cd21340   115 LAALSNsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDLEE----LLDLLSSWPSL 170
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-188 1.61e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 92.93  E-value: 1.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  54 NILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISK-------IDS 126
Cdd:cd21340    35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdPRS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370472353 127 LDALVK-LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDykmfICAYLPDLMYL 188
Cdd:cd21340   115 LAALSNsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDLEE----LLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-170 4.01e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 4.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  49 QLDFRNILRIDNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKI-D 125
Cdd:COG4886    97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpE 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1370472353 126 SLDALVKLQVLSLGNNRIDNMMNIIYlrRFKCLRTLSLSRNPISE 170
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTD 219
LRR_9 pfam14580
Leucine-rich repeat;
68-193 6.68e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.10  E-value: 6.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  68 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 144
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370472353 145 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRI 193
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-188 1.61e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 92.93  E-value: 1.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  54 NILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISK-------IDS 126
Cdd:cd21340    35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdPRS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370472353 127 LDALVK-LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDykmfICAYLPDLMYL 188
Cdd:cd21340   115 LAALSNsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDLEE----LLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-170 4.01e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 4.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  49 QLDFRNILRIDNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKI-D 125
Cdd:COG4886    97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpE 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1370472353 126 SLDALVKLQVLSLGNNRIDNMMNIIYlrRFKCLRTLSLSRNPISE 170
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTD 219
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-143 8.52e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 8.52e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370472353  70 LQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRI 143
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-170 9.21e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 9.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  59 DNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVL 136
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1370472353 137 SLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISE 170
Cdd:COG4886   256 DLSNNQLTDLPPLANLTN---LKTLDLSNNQLTD 286
LRR_9 pfam14580
Leucine-rich repeat;
68-193 6.68e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 67.10  E-value: 6.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  68 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 144
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370472353 145 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRI 193
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKV 150
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-146 1.39e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 1.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  61 LWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLG 139
Cdd:COG4886   201 LGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLS 280


                  ....*..
gi 1370472353 140 NNRIDNM 146
Cdd:COG4886   281 NNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-169 7.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 7.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  54 NILRIDNLWQFENLRKLQLDNNIIEKIEGLENL------------------------------AHLVWLDLSFNNIETIE 103
Cdd:cd21340    57 QIEKIENLENLVNLKKLYLGGNRISVVEGLENLtnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSLE 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370472353 104 GLDTLVNLEDLSLFNNRISKIDSLDALvklqvlslgnnridnmmniiyLRRFKCLRTLSLSRNPIS 169
Cdd:cd21340   137 PLAPLRNLEQLDASNNQISDLEELLDL---------------------LSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-195 4.99e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  59 DNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRIS--KIDSLDALVKLQVL 136
Cdd:COG4886   222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSL 301

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370472353 137 SLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDD 195
Cdd:COG4886   302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360
LRR_8 pfam13855
Leucine rich repeat;
66-121 1.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  66 NLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRI 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
88-143 9.49e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  88 HLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNNRI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-152 7.15e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 7.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIET--IEGLDTLVNLEDLSLFNNRISKI 124
Cdd:COG4886   232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLL 311

                          90       100
                  ....*....|....*....|....*...
gi 1370472353 125 DSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Cdd:COG4886   312 ELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-145 9.99e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 9.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370472353 110 NLEDLSLFNNRISKIDSLDALVKLQVLSL-GNNRIDN 145
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITD 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 88-128 1.42e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370472353  88 HLVWLDLSFNNIETIEGLDTLVNLEDLSL-FNNRISKIDSLD 128
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-106 4.73e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 4.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370472353  66 NLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNN-IETIEGLD 106
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-170 6.65e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  40 ILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNN 119
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370472353 120 riskiDSLDALVKLQVLSLGNNRIDNMmnIIYLRRFKCLRTLSLSRNPISE 170
Cdd:COG4886   107 -----EELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTD 150
LRR_8 pfam13855
Leucine rich repeat;
110-168 3.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370472353 110 NLEDLSLFNNRISKID--SLDALVKLQVLSLGNNRIdnmmNIIY---LRRFKCLRTLSLSRNPI 168
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLL----TTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
47-99 3.27e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370472353  47 SLQLDFRNILRIDNLW--QFENLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNI 99
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-177 4.80e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  67 LRKLQLDNN------IIEKIEGLENLAHLVWLDLSFNNIETI------EGLDTLVNLEDLSLFNNRISKID-------SL 127
Cdd:cd00116   167 LKELNLANNgigdagIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAGaaalasaLL 246

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370472353 128 DALVKLQVLSLGNNRI---DNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMF 177
Cdd:cd00116   247 SPNISLLTLSLSCNDItddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-170 5.09e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370472353  66 NLRKLQLDNNIIEK------IEGLENLAHLVWLDLSFNNI------ETIEGLDTLVNLEDLSLFNNRISK------IDSL 127
Cdd:COG5238   265 TVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaialAKAL 344

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1370472353 128 DALVKLQVLSLGNNRIDN--MMNII-YLRRFKCLRTLSLSRNPISE 170
Cdd:COG5238   345 QENTTLHSLDLSDNQIGDegAIALAkYLEGNTTLRELNLGKNNIGK 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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