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Conserved domains on  [gi|1333120313|ref|XP_023534511|]
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F-box/kelch-repeat protein OR23 [Cucurbita pepo subsp. pepo]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
96-396 2.84e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  96 SWCPLPPMPcnphvYGLCNFTPISLGPHLYVIGGSLFDtrsypidrpSSSSSAFRFDFYASLWEPISPMLSPRGSFACAA 175
Cdd:COG3055     2 TWSSLPDLP-----TPRSEAAAALLDGKVYVAGGLSGG---------SASNSFEVYDPATNTWSELAPLPGPPRHHAAAV 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 176 VPGsGQILVAGGGsrhTMFAAAGSRMSSVERYDVERDEWVALDGLPRFRAGCVGFFVGNgekrEFWVMGGYGESRTISGV 255
Cdd:COG3055    68 AQD-GKLYVFGGF---TGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDG----KIYVVGGWDDGGNVAWV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 256 FPVDeyyrdavvlelrngngNGGGRWRQIGDMweEGERRRLGKIVVIEDHhnhgqpgIFMLDGDEFFRYemtSNRWveeS 335
Cdd:COG3055   140 EVYD----------------PATGTWTQLAPL--PTPRDHLAAAVLPDGK-------ILVIGGRNGSGF---SNTW---T 188

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333120313 336 RVPRKTPFNSSYGFVALNGELYVISFLKTESAEArrlrhhkkggllymQIYDPVKKTWRSL 396
Cdd:COG3055   189 TLAPLPTARAGHAAAVLGGKILVFGGESGFSDEV--------------EAYDPATNTWTAL 235
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 20-64 1.74e-08

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22152:

Pssm-ID: 459239  Cd Length: 45  Bit Score: 50.26  E-value: 1.74e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1333120313  20 LIPGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSNILISLR 64
Cdd:cd22152     1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
96-396 2.84e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  96 SWCPLPPMPcnphvYGLCNFTPISLGPHLYVIGGSLFDtrsypidrpSSSSSAFRFDFYASLWEPISPMLSPRGSFACAA 175
Cdd:COG3055     2 TWSSLPDLP-----TPRSEAAAALLDGKVYVAGGLSGG---------SASNSFEVYDPATNTWSELAPLPGPPRHHAAAV 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 176 VPGsGQILVAGGGsrhTMFAAAGSRMSSVERYDVERDEWVALDGLPRFRAGCVGFFVGNgekrEFWVMGGYGESRTISGV 255
Cdd:COG3055    68 AQD-GKLYVFGGF---TGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDG----KIYVVGGWDDGGNVAWV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 256 FPVDeyyrdavvlelrngngNGGGRWRQIGDMweEGERRRLGKIVVIEDHhnhgqpgIFMLDGDEFFRYemtSNRWveeS 335
Cdd:COG3055   140 EVYD----------------PATGTWTQLAPL--PTPRDHLAAAVLPDGK-------ILVIGGRNGSGF---SNTW---T 188

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333120313 336 RVPRKTPFNSSYGFVALNGELYVISFLKTESAEArrlrhhkkggllymQIYDPVKKTWRSL 396
Cdd:COG3055   189 TLAPLPTARAGHAAAVLGGKILVFGGESGFSDEV--------------EAYDPATNTWTAL 235
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 20-64 1.74e-08

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 50.26  E-value: 1.74e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1333120313  20 LIPGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSNILISLR 64
Cdd:cd22152     1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch smart00612
Kelch domain;
123-178 7.47e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 7.47e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1333120313  123 HLYVIGGslfdtrsypIDRPSSSSSAFRFDFYASLWEPISPMLSPRGSFACAAVPG 178
Cdd:smart00612   1 KIYVVGG---------FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 21-60 1.34e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.06  E-value: 1.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1333120313  21 IPGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSNIL 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
PHA03098 PHA03098
kelch-like protein; Provisional
 90-223 2.51e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  90 FDPLNLSWCPLPPMPCnPHVYGLCnftpISLGPHLYVIGGSlfdtrSYpIDRPSSSSSAFRFDFYASLWEPISPMLSPRG 169
Cdd:PHA03098  411 FSLNTNKWSKGSPLPI-SHYGGCA----IYHDGKIYVIGGI-----SY-IDNIKVYNIVESYNPVTNKWTELSSLNFPRI 479

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1333120313 170 -SFACAAvpgSGQILVAGGGSRHtmfaaagSRMSSVERYDVERDEWVALDGLPRF 223
Cdd:PHA03098  480 nASLCIF---NNKIYVVGGDKYE-------YYINEIEVYDDKTNTWTLFCKFPKV 524
FBOX smart00256
A Receptor for Ubiquitination Targets;
24-58 1.26e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1333120313   24 LPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSN 58
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSH 35
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 113-164 1.46e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333120313 113 CNFTPISLGPHLYVIGGSlfdtrsypiDRPSSSSSAFRFDFYASLWEPISPM 164
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGF---------DGNQSLNSVEVYDPETNTWSKLPSM 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
96-396 2.84e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  96 SWCPLPPMPcnphvYGLCNFTPISLGPHLYVIGGSLFDtrsypidrpSSSSSAFRFDFYASLWEPISPMLSPRGSFACAA 175
Cdd:COG3055     2 TWSSLPDLP-----TPRSEAAAALLDGKVYVAGGLSGG---------SASNSFEVYDPATNTWSELAPLPGPPRHHAAAV 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 176 VPGsGQILVAGGGsrhTMFAAAGSRMSSVERYDVERDEWVALDGLPRFRAGCVGFFVGNgekrEFWVMGGYGESRTISGV 255
Cdd:COG3055    68 AQD-GKLYVFGGF---TGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDG----KIYVVGGWDDGGNVAWV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 256 FPVDeyyrdavvlelrngngNGGGRWRQIGDMweEGERRRLGKIVVIEDHhnhgqpgIFMLDGDEFFRYemtSNRWveeS 335
Cdd:COG3055   140 EVYD----------------PATGTWTQLAPL--PTPRDHLAAAVLPDGK-------ILVIGGRNGSGF---SNTW---T 188

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333120313 336 RVPRKTPFNSSYGFVALNGELYVISFLKTESAEArrlrhhkkggllymQIYDPVKKTWRSL 396
Cdd:COG3055   189 TLAPLPTARAGHAAAVLGGKILVFGGESGFSDEV--------------EAYDPATNTWTAL 235
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
89-360 5.18e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.59  E-value: 5.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  89 LFDPLNLSWCPLPPMPcNPHVYGlcnFTPISLGPHLYVIGGslfdtRSYPIDRPSSSSSAFRFDFYASLWEPISPMLSPR 168
Cdd:COG3055    42 VYDPATNTWSELAPLP-GPPRHH---AAAVAQDGKLYVFGG-----FTGANPSSTPLNDVYVYDPATNTWTKLAPMPTPR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 169 GSFAcaAVPGSGQILVAGGGSrhtmfaaAGSRMSSVERYDVERDEWVALDGLPRFRAGCVGFFVGNGekrEFWVMGGYGE 248
Cdd:COG3055   113 GGAT--ALLLDGKIYVVGGWD-------DGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDG---KILVIGGRNG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 249 SrtisgvfpvdeyyrdavvlelrngngNGGGRWRQIGDMWEEGERRRL----GKIVVIEdhhnhGQPGIFmldgDEFFRY 324
Cdd:COG3055   181 S--------------------------GFSNTWTTLAPLPTARAGHAAavlgGKILVFG-----GESGFS----DEVEAY 225

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1333120313 325 EMTSNRWVEESRVPRktpfnSSYGFVAL--NGELYVIS 360
Cdd:COG3055   226 DPATNTWTALGELPT-----PRHGHAAVltDGKVYVIG 258
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 20-64 1.74e-08

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 50.26  E-value: 1.74e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1333120313  20 LIPGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSNILISLR 64
Cdd:cd22152     1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch smart00612
Kelch domain;
123-178 7.47e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 7.47e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1333120313  123 HLYVIGGslfdtrsypIDRPSSSSSAFRFDFYASLWEPISPMLSPRGSFACAAVPG 178
Cdd:smart00612   1 KIYVVGG---------FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
94-208 1.11e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 43.61  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  94 NLSWCPLPPMPcnphvYGLCNFTPISLGPHLYVIGGSlfdtrsypidrPSSSSSAFRFDFYASLWEPISPMLSPRGSFAc 173
Cdd:COG3055   184 SNTWTTLAPLP-----TARAGHAAAVLGGKILVFGGE-----------SGFSDEVEAYDPATNTWTALGELPTPRHGHA- 246

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1333120313 174 aAVPGSGQILVAGGGSRHtmfAAAGSRMSSVERYD 208
Cdd:COG3055   247 -AVLTDGKVYVIGGETKP---GVRTPLVTSAEVYD 277
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 21-60 1.34e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.06  E-value: 1.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1333120313  21 IPGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSNIL 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
PHA03098 PHA03098
kelch-like protein; Provisional
 90-223 2.51e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  90 FDPLNLSWCPLPPMPCnPHVYGLCnftpISLGPHLYVIGGSlfdtrSYpIDRPSSSSSAFRFDFYASLWEPISPMLSPRG 169
Cdd:PHA03098  411 FSLNTNKWSKGSPLPI-SHYGGCA----IYHDGKIYVIGGI-----SY-IDNIKVYNIVESYNPVTNKWTELSSLNFPRI 479

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1333120313 170 -SFACAAvpgSGQILVAGGGSRHtmfaaagSRMSSVERYDVERDEWVALDGLPRF 223
Cdd:PHA03098  480 nASLCIF---NNKIYVVGGDKYE-------YYINEIEVYDDKTNTWTLFCKFPKV 524
PHA03098 PHA03098
kelch-like protein; Provisional
 90-226 2.69e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  90 FDPLNLSWCPLPPMPCNPHVYGLCNFTPislgpHLYVIGGslfdtrsypIDRPSSSSSAFRFDFYASLWEPISPMLSPRG 169
Cdd:PHA03098  316 YDTKTKSWNKVPELIYPRKNPGVTVFNN-----RIYVIGG---------IYNSISLNTVESWKPGESKWREEPPLIFPRY 381

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333120313 170 SfACAaVPGSGQILVAGGGSRHtmfaaaGSRMSSVERYDVERDEWVALDGLPRFRAG 226
Cdd:PHA03098  382 N-PCV-VNVNNLIYVIGGISKN------DELLKTVECFSLNTNKWSKGSPLPISHYG 430
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 22-58 2.73e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 38.21  E-value: 2.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1333120313  22 PGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSN 58
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSP 37
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 21-60 5.82e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 37.46  E-value: 5.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1333120313  21 IPGLPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSNIL 60
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
24-58 1.26e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1333120313   24 LPNDVAALVLSFLPYSHHARLKSTCKSWRLFFSSN 58
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSH 35
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 113-164 1.46e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333120313 113 CNFTPISLGPHLYVIGGSlfdtrsypiDRPSSSSSAFRFDFYASLWEPISPM 164
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGF---------DGNQSLNSVEVYDPETNTWSKLPSM 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 167-214 1.74e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 1.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333120313 167 PRGSFACAAVPGsgQILVAGGGSRHTmfaaagsRMSSVERYDVERDEW 214
Cdd:pfam01344   1 RRSGAGVVVVGG--KIYVIGGFDGNQ-------SLNSVEVYDPETNTW 39
Kelch smart00612
Kelch domain;
181-227 3.58e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 3.58e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1333120313  181 QILVAGGGSRhtmfaaaGSRMSSVERYDVERDEWVALDGLPRFRAGC 227
Cdd:smart00612   1 KIYVVGGFDG-------GQRLKSVEVYDPETNKWTPLPSMPTPRSGH 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 24-56 6.06e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 34.34  E-value: 6.06e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1333120313  24 LPNDVAALVLSFLPYSHHARLKSTCKSWRLFFS 56
Cdd:cd09917     3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
PHA03098 PHA03098
kelch-like protein; Provisional
 42-393 9.36e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.21  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313  42 ARLKSTCKSWRLFFSSNILISLRFTH-------PNSLSHLLCFFPQDPLIASPILFDPLNLSWCPLPPMPCNPHVyglCN 114
Cdd:PHA03098  211 KRWKLRIKKKKIVFNKRCIKIIYSKKynlnkilPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYV---YC 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 115 FTPISLGPHLYVIGGSlfdtrsypIDRPSSSSSAFRFDFYASLWEPISPMLSPRGSFACAAVpgSGQILVAGGgsrhtmf 194
Cdd:PHA03098  288 FGSVVLNNVIYFIGGM--------NKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVF--NNRIYVIGG------- 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 195 AAAGSRMSSVERYDVERDEWVALDGL--PRFRAGCVgfFVGNgekrEFWVMGGygesrtisgvfpVDEYYRDAVVLElrn 272
Cdd:PHA03098  351 IYNSISLNTVESWKPGESKWREEPPLifPRYNPCVV--NVNN----LIYVIGG------------ISKNDELLKTVE--- 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333120313 273 GNGNGGGRWRQIGDMweegeRRRL---------GKIVVIEDHHNHGQPGIFmldgDEFFRYEMTSNRWVEES--RVPRkt 341
Cdd:PHA03098  410 CFSLNTNKWSKGSPL-----PISHyggcaiyhdGKIYVIGGISYIDNIKVY----NIVESYNPVTNKWTELSslNFPR-- 478

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333120313 342 pFNSSYGfvALNGELYVISFLKTESAEArrlrhhkkggllYMQIYDPVKKTW 393
Cdd:PHA03098  479 -INASLC--IFNNKIYVVGGDKYEYYIN------------EIEVYDDKTNTW 515
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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