|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02336 |
PLN02336 |
phosphoethanolamine N-methyltransferase |
19-522 |
0e+00 |
|
phosphoethanolamine N-methyltransferase
Pssm-ID: 177970 [Multi-domain] Cd Length: 475 Bit Score: 971.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 19 MEHSAGLTLEGMLLDSNASDLDKEERPEVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIALDFIEGVIKKNESING 98
Cdd:PLN02336 1 KEHSVDLTVEAMMLDSKASDLDKEERPEILSLLPPYEGKSVLELGAGIGRFTGELAKKAGQVIALDFIESVIKKNESING 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 99 HHKNVKFMCADVTSPELKVSENSVDLIFSNWLLMYLSDKEVKNLAERMVKWLKVGGYIFFRESCFHQSGDCKRKYNPTHY 178
Cdd:PLN02336 81 HYKNVKFMCADVTSPDLNISDGSVDLIFSNWLLMYLSDKEVENLAERMVKWLKVGGYIFFRESCFHQSGDSKRKNNPTHY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 179 REPRFYTKVFKECHMQDEGGDCYELSLVGYKCIGAYARNKKNQNQvlnhlyfvssfansqalnqknqiclwvfqICWIWQ 258
Cdd:PLN02336 161 REPRFYTKVFKECHTRDEDGNSFELSLVGCKCIGAYVKNKKNQNQ-----------------------------ICWLWQ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 259 KQkSSNDDRGFQRFLDTVQYKCSGILRYERVFGPGFVSTGGIETTKEFVGKLDLKPGQRVLDVGCGIGGGDFYMAENFDV 338
Cdd:PLN02336 212 KV-SSTNDKGFQRFLDNVQYKSSGILRYERVFGEGFVSTGGLETTKEFVDKLDLKPGQKVLDVGCGIGGGDFYMAENFDV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 339 EVVGIDLSINMISLALERAIGLKCAVEFEVADCTKKVYPDNAFDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITDY 418
Cdd:PLN02336 291 HVVGIDLSVNMISFALERAIGRKCSVEFEVADCTKKTYPDNSFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLISDY 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 419 CKSSGAPSPAFAEYIKQRGYDLHDVKSYGQMLEEAGFKDVVAEDRTDQFMSVLQRELDAVEKEKDAFIHDFSEEDYNDIV 498
Cdd:PLN02336 371 CRSPGTPSPEFAEYIKQRGYDLHDVQAYGQMLKDAGFDDVIAEDRTDQFLQVLQRELDAVEKEKDEFISDFSEEDYNDIV 450
|
490 500
....*....|....*....|....
gi 1280981287 499 GGWKAKLERCWCGEQKWGLFIAHK 522
Cdd:PLN02336 451 GGWKAKLVRSSSGEQKWGLFIAKK 474
|
|
| PTZ00098 |
PTZ00098 |
phosphoethanolamine N-methyltransferase; Provisional |
271-522 |
1.36e-66 |
|
phosphoethanolamine N-methyltransferase; Provisional
Pssm-ID: 173391 [Multi-domain] Cd Length: 263 Bit Score: 215.99 E-value: 1.36e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 271 RFLDTVQYKCSGILRYERVFGPGFVSTGGIETTKEFVGKLDLKPGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMI 350
Cdd:PTZ00098 9 TYLENNQYSDEGIKAYEFIFGEDYISSGGIEATTKILSDIELNENSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 351 SLALERAIGlKCAVEFEVADCTKKVYPDNAFDVIYSRDTILHI--QDKPALFRSFYKWVKPGGKILITDYCKSSGAP-SP 427
Cdd:PTZ00098 89 NIAKLRNSD-KNKIEFEANDILKKDFPENTFDMIYSRDAILHLsyADKKKLFEKCYKWLKPNGILLITDYCADKIENwDE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 428 AFAEYIKQRGYDLHDVKSYGQMLEEAGFKDVVAEDRTDQFMSVLQRELDAVEKEKDAFIHDFSEEDYNDIVGGWKAKLER 507
Cdd:PTZ00098 168 EFKAYIKKRKYTLIPIQEYGDLIKSCNFQNVVAKDISDYWLELLQVELKKLEEKKEEFLKLYSEKEYNSLKDGWTRKIKD 247
|
250
....*....|....*
gi 1280981287 508 CWCGEQKWGLFIAHK 522
Cdd:PTZ00098 248 TKRKLQKWGYFKAQK 262
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
301-456 |
1.45e-30 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 115.86 E-value: 1.45e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 301 ETTKEFVGKLDLKPGQRVLDVGCGIGGGDFYMAENfDVEVVGIDLSINMISLALERAIGLKCAVEFEVADCTKKVYPDNA 380
Cdd:COG2226 9 DGREALLAALGLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPFPDGS 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1280981287 381 FDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITDyckssgapspafaeyikqrgYDLHDVKSYGQMLEEAGFK 456
Cdd:COG2226 88 FDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVD--------------------FSPPDLAELEELLAEAGFE 143
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
263-417 |
1.64e-30 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 116.18 E-value: 1.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 263 SNDDrgFQRFLD-TVQYKCSGILRYERVFGPGfvstgGIETTKEFVGKLDLKPGQRVLDVGCGIGGGDFYMAENFDVEVV 341
Cdd:COG2230 6 GNDF--YRLFLDpTMTYSCAYFEDPDDTLEEA-----QEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 342 GIDLSINMISLALERA--IGLKCAVEFEVADCTkKVYPDNAFDVIYSRDTILHIQDK--PALFRSFYKWVKPGGKILITD 417
Cdd:COG2230 79 GVTLSPEQLEYARERAaeAGLADRVEVRLADYR-DLPADGQFDAIVSIGMFEHVGPEnyPAYFAKVARLLKPGGRLLLHT 157
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
318-411 |
2.29e-25 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 99.95 E-value: 2.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 318 VLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLALERAIGLKCAVEFEVADCTKKVYPDNAFDVIYSRDTILHI--QD 395
Cdd:pfam13649 1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLpdPD 80
|
90
....*....|....*.
gi 1280981287 396 KPALFRSFYKWVKPGG 411
Cdd:pfam13649 81 LEAALREIARVLKPGG 96
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
305-418 |
4.74e-25 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 100.09 E-value: 4.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 305 EFVGKLdLKPGQRVLDVGCGIGGGDFYMAENFdVEVVGIDLSINMISLALERAIGLKcaVEFEVADCTKKVYPDNAFDVI 384
Cdd:COG2227 16 ALLARL-LPAGGRVLDVGCGTGRLALALARRG-ADVTGVDISPEALEIARERAAELN--VDFVQGDLEDLPLEDGSFDLV 91
|
90 100 110
....*....|....*....|....*....|....
gi 1280981287 385 YSRDTILHIQDKPALFRSFYKWVKPGGKILITDY 418
Cdd:COG2227 92 ICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
314-417 |
1.46e-21 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 89.11 E-value: 1.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 314 PGQRVLDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALERAIGlkcaVEFEVADCTKkVYPDNAFDVIYSRDTILH 392
Cdd:COG4106 1 PPRRVLDLGCGTGRLTALLAERFpGARVTGVDLSPEMLARARARLPN----VRFVVADLRD-LDPPEPFDLVVSNAALHW 75
|
90 100
....*....|....*....|....*
gi 1280981287 393 IQDKPALFRSFYKWVKPGGKILITD 417
Cdd:COG4106 76 LPDHAALLARLAAALAPGGVLAVQV 100
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
319-415 |
3.21e-21 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 88.11 E-value: 3.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 319 LDVGCGIGGGDFYMAENFdVEVVGIDLSINMISLALERAIGLKcaVEFEVADCTKKVYPDNAFDVIYSRDTILHIQDKPA 398
Cdd:pfam08241 1 LDVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREG--LTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77
|
90
....*....|....*..
gi 1280981287 399 LFRSFYKWVKPGGKILI 415
Cdd:pfam08241 78 ALREIARVLKPGGILII 94
|
|
| PRK08317 |
PRK08317 |
hypothetical protein; Provisional |
299-417 |
5.46e-21 |
|
hypothetical protein; Provisional
Pssm-ID: 181382 [Multi-domain] Cd Length: 241 Bit Score: 91.92 E-value: 5.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 299 GIETTKEFV-GKLDLKPGQRVLDVGCGIGGGDFYMAENF--DVEVVGIDLSINMISLALERAIGLKCAVEFEVADCTKKV 375
Cdd:PRK08317 3 DFRRYRARTfELLAVQPGDRVLDVGCGPGNDARELARRVgpEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLP 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1280981287 376 YPDNAFDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITD 417
Cdd:PRK08317 83 FPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLD 124
|
|
| Methyltransf_23 |
pfam13489 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
310-458 |
1.27e-20 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 404385 [Multi-domain] Cd Length: 162 Bit Score: 88.64 E-value: 1.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 310 LDLKPGQRVLDVGCGIGggdfYMAENFD---VEVVGIDLSINMISLALEraiglkcAVEFEVADCTKKVYPDNAFDVIYS 386
Cdd:pfam13489 18 PKLPSPGRVLDFGCGTG----IFLRLLRaqgFSVTGVDPSPIAIERALL-------NVRFDQFDEQEAAVPAGKFDVIVA 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1280981287 387 RDTILHIQDKPALFRSFYKWVKPGGKILITDYCKSSGAPSPA-FAEYIKQRG--YDLHDVKSYGQMLEEAGFKDV 458
Cdd:pfam13489 87 REVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLlEWPYLRPRNghISLFSARSLKRLLEEAGFEVV 161
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
304-455 |
1.98e-20 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 88.90 E-value: 1.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 304 KEFVGKLDLKPGQRVLDVGCGIGGGDFYMAENFDvEVVGIDLSINMISLALERAIGlkcaVEFEVADCTKKVYPDNAFDV 383
Cdd:COG4976 36 EELLARLPPGPFGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREKGVY----DRLLVADLADLAEPDGRFDL 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1280981287 384 IYSRDTILHIQDKPALFRSFYKWVKPGGKILITdyckssgapspafAEYIKQRGYDLHDVKSYGQMLEEAGF 455
Cdd:COG4976 111 IVAADVLTYLGDLAAVFAGVARALKPGGLFIFS-------------VEDADGSGRYAHSLDYVRDLLAAAGF 169
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
33-160 |
2.69e-20 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 87.36 E-value: 2.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 33 DSNASDLDkeERPEVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIALDFIEGVIKK-NESINGHHKNVKFMCADVT 111
Cdd:COG2226 2 DRVAARYD--GREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELaRERAAEAGLNVEFVVGDAE 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1280981287 112 spELKVSENSVDLIFSNWLLMYLSDKEvKNLAErMVKWLKVGGYIFFRE 160
Cdd:COG2226 80 --DLPFPDGSFDLVISSFVLHHLPDPE-RALAE-IARVLKPGGRLVVVD 124
|
|
| Methyltransf_31 |
pfam13847 |
Methyltransferase domain; This family appears to have methyltransferase activity. |
312-454 |
2.69e-19 |
|
Methyltransferase domain; This family appears to have methyltransferase activity.
Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 84.78 E-value: 2.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 312 LKPGQRVLDVGCGIGGGDFYMAE--NFDVEVVGIDLSINMISLALERAIGLKCA-VEFEVADCTK--KVYPDNAFDVIYS 386
Cdd:pfam13847 1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEElpELLEDDKFDVVIS 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 387 RDTILHIQDKPALFRSFYKWVKPGGKILITDYCKSSGAPSPAFAE--YIKQRGYDLHDVKSYGQMLEEAG 454
Cdd:pfam13847 81 NCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDstYYAGCVGGAILKKKLYELLEEAG 150
|
|
| PLN02244 |
PLN02244 |
tocopherol O-methyltransferase |
300-462 |
2.71e-19 |
|
tocopherol O-methyltransferase
Pssm-ID: 215135 [Multi-domain] Cd Length: 340 Bit Score: 89.03 E-value: 2.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 300 IETTKEFVG--KLDLKPGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLA--LERAIGLKCAVEFEVADCTKKV 375
Cdd:PLN02244 102 IEESLAWAGvpDDDEKRPKRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAARAnaLAAAQGLSDKVSFQVADALNQP 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 376 YPDNAFDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITDYCKSSGAPS-----PAFAEYIKQ--RGYDLHD---VKS 445
Cdd:PLN02244 182 FEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIVTWCHRDLEPGetslkPDEQKLLDKicAAYYLPAwcsTSD 261
|
170
....*....|....*..
gi 1280981287 446 YGQMLEEAGFKDVVAED 462
Cdd:PLN02244 262 YVKLAESLGLQDIKTED 278
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
311-418 |
3.56e-19 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 85.74 E-value: 3.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 311 DLKPGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLALERAIGLKCA-VEFEVADCTK-KVYPDNAFDVIYSRD 388
Cdd:COG0500 23 RLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLAElDPLPAESFDLVVAFG 102
|
90 100 110
....*....|....*....|....*....|..
gi 1280981287 389 TILHIQDKP--ALFRSFYKWVKPGGKILITDY 418
Cdd:COG0500 103 VLHHLPPEEreALLRELARALKPGGVLLLSAS 134
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
59-154 |
4.99e-18 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 79.14 E-value: 4.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 59 VLELGAGIGRFTGDLAEKAG-QVIALDFIEGVIKK-NESINGHHKNVKFMCADVTspELKVSENSVDLIFSNWLLMYLSD 136
Cdd:pfam13649 1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERaRERAAEAGLNVEFVQGDAE--DLPFPDGSFDLVVSSGVLHHLPD 78
|
90
....*....|....*...
gi 1280981287 137 KEVKNLAERMVKWLKVGG 154
Cdd:pfam13649 79 PDLEAALREIARVLKPGG 96
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
319-413 |
2.91e-16 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 74.33 E-value: 2.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 319 LDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALER--AIGLKCAVEFEVADCTKKVYPDNAFDVIYSRDTILHIQD 395
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERlaALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80
|
90
....*....|....*...
gi 1280981287 396 KPALFRSFYKWVKPGGKI 413
Cdd:pfam08242 81 PRAVLRNIRRLLKPGGVL 98
|
|
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
308-495 |
1.49e-15 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 76.98 E-value: 1.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 308 GKLDLKPGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLALER--AIGLKCAVEFEVADctkkvYPD--NAFDV 383
Cdd:pfam02353 55 DKLGLKPGMTLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYKLARKRvaAEGLARKVEVLLQD-----YRDfdEPFDR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 384 IYSRDTILHIQDK--PALFRSFYKWVKPGGKILI-------TDYCKSSGAPSPAFAEYIKQRGY--DLHDVKSYGQmleE 452
Cdd:pfam02353 130 IVSVGMFEHVGHEnyDTFFKKLYNLLPPGGLMLLhtitglhPDETSERGLPLKFIDKYIFPGGElpSISMIVESSS---E 206
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1280981287 453 AGFKDVVAEDRTDQFMSVLQRELDAVEKEKDAFIHDFSEEDYN 495
Cdd:pfam02353 207 AGFTVEDVESLRPHYAKTLDLWAENLQANKDEAIALQSEEFYR 249
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
60-158 |
1.99e-15 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 71.54 E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 60 LELGAGIGRFTGDLAEKAGQVIALDFIEGVIKKNESiNGHHKNVKFMCADVTspELKVSENSVDLIFSNWLLMYLSDKEv 139
Cdd:pfam08241 1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELARE-KAPREGLTFVVGDAE--DLPFPDNSFDLVLSSEVLHHVEDPE- 76
|
90
....*....|....*....
gi 1280981287 140 KNLAErMVKWLKVGGYIFF 158
Cdd:pfam08241 77 RALRE-IARVLKPGGILII 94
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
317-418 |
2.11e-15 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 72.08 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 317 RVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLALERAIGLKCA-VEFEVADCTK-KVYPDNAFDVIYSRDTILHI- 393
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEElPPEADESFDVIISDPPLHHLv 80
|
90 100
....*....|....*....|....*
gi 1280981287 394 QDKPALFRSFYKWVKPGGKILITDY 418
Cdd:cd02440 81 EDLARFLEEARRLLKPGGVLVLTLV 105
|
|
| ubiE |
PRK00216 |
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ... |
304-458 |
1.29e-14 |
|
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;
Pssm-ID: 234689 [Multi-domain] Cd Length: 239 Bit Score: 73.26 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 304 KEFVGKLDLKPGQRVLDVGCGIggGD--FYMAENFDV--EVVGIDLSINMISLALERAIGLKCA--VEFEVADCTKKVYP 377
Cdd:PRK00216 41 RKTIKWLGVRPGDKVLDLACGT--GDlaIALAKAVGKtgEVVGLDFSEGMLAVGREKLRDLGLSgnVEFVQGDAEALPFP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 378 DNAFDVIysrdTI---L-HIQDKPALFRSFYKWVKPGGKILITDYCKSSGAPspafaeyIKQrGYDLH------------ 441
Cdd:PRK00216 119 DNSFDAV----TIafgLrNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPP-------LKK-AYDFYlfkvlpligkli 186
|
170 180 190
....*....|....*....|....*....|....*
gi 1280981287 442 --DVKSY----------------GQMLEEAGFKDV 458
Cdd:PRK00216 187 skNAEAYsylaesirafpdqeelAAMLEEAGFERV 221
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
44-158 |
1.34e-14 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 70.43 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 44 RPEVLSLLPPH--EGKSVLELGAGIGRFTGDLAEKAGQVIALDFIEGVIKKNESiNGHHKNVKFMCADVTspELKVSENS 121
Cdd:COG2227 11 DRRLAALLARLlpAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARE-RAAELNVDFVQGDLE--DLPLEDGS 87
|
90 100 110
....*....|....*....|....*....|....*..
gi 1280981287 122 VDLIFSNWLLMYLSDkeVKNLAERMVKWLKVGGYIFF 158
Cdd:COG2227 88 FDLVICSEVLEHLPD--PAALLRELARLLKPGGLLLL 122
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
309-386 |
4.32e-14 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 73.73 E-value: 4.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 309 KLDLKPGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLALERAIGLkcAVEFEVADctkkvYPD--NAFDVIYS 386
Cdd:PRK11705 162 KLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVGVTISAEQQKLAQERCAGL--PVEIRLQD-----YRDlnGQFDRIVS 234
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
55-158 |
2.61e-13 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 66.00 E-value: 2.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 55 EGKSVLELGAGIGRFTGDLAEK--AGQVIALDFIEGVIkknESINGHHKNVKFMCADVTSPELkvsENSVDLIFSNWLLM 132
Cdd:COG4106 1 PPRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEML---ARARARLPNVRFVVADLRDLDP---PEPFDLVVSNAALH 74
|
90 100
....*....|....*....|....*.
gi 1280981287 133 YLSDKEVknLAERMVKWLKVGGYIFF 158
Cdd:COG4106 75 WLPDHAA--LLARLAAALAPGGVLAV 98
|
|
| arsM |
PRK11873 |
arsenite methyltransferase; |
312-464 |
4.21e-12 |
|
arsenite methyltransferase;
Pssm-ID: 237007 [Multi-domain] Cd Length: 272 Bit Score: 66.51 E-value: 4.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 312 LKPGQRVLDVGCGIGggdfymaenFDV-----------EVVGIDLSINMISLALERAIGLKCA-VEFEVADCTKKVYPDN 379
Cdd:PRK11873 75 LKPGETVLDLGSGGG---------FDCflaarrvgptgKVIGVDMTPEMLAKARANARKAGYTnVEFRLGEIEALPVADN 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 380 AFDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITDYCksSGAPSPafaEYIKQRGyDLH--------DVKSYGQMLE 451
Cdd:PRK11873 146 SVDVIISNCVINLSPDKERVFKEAFRVLKPGGRFAISDVV--LRGELP---EEIRNDA-ELYagcvagalQEEEYLAMLA 219
|
170
....*....|....
gi 1280981287 452 EAGFKDV-VAEDRT 464
Cdd:PRK11873 220 EAGFVDItIQPKRE 233
|
|
| Ubie_methyltran |
pfam01209 |
ubiE/COQ5 methyltransferase family; |
304-464 |
1.15e-11 |
|
ubiE/COQ5 methyltransferase family;
Pssm-ID: 395966 [Multi-domain] Cd Length: 228 Bit Score: 64.38 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 304 KEFVGKLD-LKPGQRVLDVGCGIGGGDFYMAENFDV--EVVGIDLSINMISLALERAI-GLKCAVEFEVADCTKKVYPDN 379
Cdd:pfam01209 31 KDFTMKCMgVKRGNKFLDVAGGTGDWTFGLSDSAGSsgKVVGLDINENMLKEGEKKAKeEGKYNIEFLQGNAEELPFEDD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 380 AFDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITDYCKSSGAP-SPAFAEYIKQ-------------RGY------- 438
Cdd:pfam01209 111 SFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLlSQAYELYFKYvmpfmgkmfaksyKSYqylqesi 190
|
170 180
....*....|....*....|....*..
gi 1280981287 439 -DLHDVKSYGQMLEEAGFKDVVAEDRT 464
Cdd:pfam01209 191 rDFPDQKTLASMFEKAGFKSVGYESLT 217
|
|
| BioC |
TIGR02072 |
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ... |
316-478 |
2.79e-11 |
|
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Pssm-ID: 273953 [Multi-domain] Cd Length: 240 Bit Score: 63.46 E-value: 2.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 316 QRVLDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALERaigLKCAVEFEVADCTKKVYPDNAFDVIYSRDTILHIQ 394
Cdd:TIGR02072 36 ASVLDIGCGTGYLTRALLKRFpQAEFIALDISAGMLAQAKTK---LSENVQFICGDAEKLPLEDSSFDLIVSNLALQWCD 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 395 DKPALFRSFYKWVKPGGKILITDYCKSSgapspaFAEY---IKQRGYDLHDVKSYGQMLEEAgFKDVVAEDR--TDQFMS 469
Cdd:TIGR02072 113 DLSQALSELARVLKPGGLLAFSTFGPGT------LHELrqsFGQHGLRYLSLDELKALLKNS-FELLTLEEEliTLSFDD 185
|
170
....*....|.
gi 1280981287 470 VLQ--RELDAV 478
Cdd:TIGR02072 186 PLDvlRHLKKT 196
|
|
| Methyltransf_31 |
pfam13847 |
Methyltransferase domain; This family appears to have methyltransferase activity. |
53-165 |
3.75e-11 |
|
Methyltransferase domain; This family appears to have methyltransferase activity.
Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 61.28 E-value: 3.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 53 PHEGKSVLELGAGIGRFTGDLAEKAG---QVIALDFIEGVIKKNESINGHH--KNVKFMCADVTSPELKVSENSVDLIFS 127
Cdd:pfam13847 1 IDKGMRVLDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKARENAQKLgfDNVEFEQGDIEELPELLEDDKFDVVIS 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 1280981287 128 NWLLMYLSDKeVKNLaERMVKWLKVGGYIFFRESCFHQ 165
Cdd:pfam13847 81 NCVLNHIPDP-DKVL-QEILRVLKPGGRLIISDPDSLA 116
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
59-158 |
7.77e-11 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 58.98 E-value: 7.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 59 VLELGAGIGRFTGDLAE-KAGQVIALDFIEGVIKKNESI--NGHHKNVKFMCADVTSPeLKVSENSVDLIFSNWLLMYLS 135
Cdd:cd02440 2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKAaaALLADNVEVLKGDAEEL-PPEADESFDVIISDPPLHHLV 80
|
90 100
....*....|....*....|...
gi 1280981287 136 DkEVKNLAERMVKWLKVGGYIFF 158
Cdd:cd02440 81 E-DLARFLEEARRLLKPGGVLVL 102
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
28-158 |
8.34e-11 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 61.17 E-value: 8.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 28 EGMLLDSNASDLDKEERPEVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIALDFIEGVIKKNESINGHhknVKFMC 107
Cdd:COG4976 19 DAALVEDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVY---DRLLV 95
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1280981287 108 ADVTspELKVSENSVDLIFSNWLLMYLSDkeVKNLAERMVKWLKVGGYIFF 158
Cdd:COG4976 96 ADLA--DLAEPDGRFDLIVAADVLTYLGD--LAAVFAGVARALKPGGLFIF 142
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
37-158 |
5.68e-10 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 59.16 E-value: 5.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 37 SDLDKEERPEVLSLLPPHE----GKSVLELGAGIGRFTGDLAEKAG-QVIALDFIEGVI---KKNESINGHHkNVKFMCA 108
Cdd:COG0500 4 SYYSDELLPGLAALLALLErlpkGGRVLDLGCGTGRNLLALAARFGgRVIGIDLSPEAIalaRARAAKAGLG-NVEFLVA 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1280981287 109 DVTSPElKVSENSVDLIFSNWLLMYLSDKEVKNLAERMVKWLKVGGYIFF 158
Cdd:COG0500 83 DLAELD-PLPAESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLL 131
|
|
| PRK08317 |
PRK08317 |
hypothetical protein; Provisional |
44-156 |
2.26e-09 |
|
hypothetical protein; Provisional
Pssm-ID: 181382 [Multi-domain] Cd Length: 241 Bit Score: 58.02 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 44 RPEVLSLLPPHEGKSVLELGAGIGRFTGDLAE---KAGQVIALDFIEGVIK-KNESINGHHKNVKFMCADVTSpeLKVSE 119
Cdd:PRK08317 8 RARTFELLAVQPGDRVLDVGCGPGNDARELARrvgPEGRVVGIDRSEAMLAlAKERAAGLGPNVEFVRGDADG--LPFPD 85
|
90 100 110
....*....|....*....|....*....|....*..
gi 1280981287 120 NSVDLIFSNWLLMYLSDKEvKNLAErMVKWLKVGGYI 156
Cdd:PRK08317 86 GSFDAVRSDRVLQHLEDPA-RALAE-IARVLRPGGRV 120
|
|
| BioC |
TIGR02072 |
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ... |
48-158 |
1.72e-08 |
|
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Pssm-ID: 273953 [Multi-domain] Cd Length: 240 Bit Score: 55.37 E-value: 1.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 48 LSLLPPH---EGKSVLELGAGIGRFTGDLAEK--AGQVIALDFIEGVIKKNESINGhhKNVKFMCADVTspELKVSENSV 122
Cdd:TIGR02072 24 LALLKEKgifIPASVLDIGCGTGYLTRALLKRfpQAEFIALDISAGMLAQAKTKLS--ENVQFICGDAE--KLPLEDSSF 99
|
90 100 110
....*....|....*....|....*....|....*...
gi 1280981287 123 DLIFSNWLLMYLSDKE--VKNLAErmvkWLKVGGYIFF 158
Cdd:TIGR02072 100 DLIVSNLALQWCDDLSqaLSELAR----VLKPGGLLAF 133
|
|
| PKS_MT |
smart00828 |
Methyltransferase in polyketide synthase (PKS) enzymes; |
317-491 |
2.00e-08 |
|
Methyltransferase in polyketide synthase (PKS) enzymes;
Pssm-ID: 214839 [Multi-domain] Cd Length: 224 Bit Score: 54.73 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 317 RVLDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALER--AIGLKCAVEFEVADCTKKVYPDNaFDVIYSRDTILHI 393
Cdd:smart00828 2 RVLDFGCGYGSDLIDLAERHpHLQLHGYTISPEQAEVGRERirALGLQGRIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 394 QDKPALFRSFYKWVKPGGKILITDYCKSSGAP---------SPAFAEYIKQ---RGYDLHDVKSYGQ----MLEEAGFkd 457
Cdd:smart00828 81 KDKMDLFSNISRHLKDGGHLVLADFIANLLSAieheettsyLVTREEWAELlarNNLRVVEGVDASLeianFLYDPGF-- 158
|
170 180 190
....*....|....*....|....*....|....
gi 1280981287 458 vvaedrTDQFMSVLQRELDAVEKEKDAFIHDFSE 491
Cdd:smart00828 159 ------EDNLERLYQDDLDEVTKRHFRGIANLGK 186
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
46-158 |
6.26e-08 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 52.24 E-value: 6.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 46 EVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAG-QVIALDF----IEGVIKKNESInGHHKNVKFMCADVTSPELkvsEN 120
Cdd:COG2230 42 LILRKLGLKPGMRVLDIGCGWGGLALYLARRYGvRVTGVTLspeqLEYARERAAEA-GLADRVEVRLADYRDLPA---DG 117
|
90 100 110
....*....|....*....|....*....|....*...
gi 1280981287 121 SVDLIFSNWLLMYLSDKEVKNLAERMVKWLKVGGYIFF 158
Cdd:COG2230 118 QFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLL 155
|
|
| Trm11 |
COG1041 |
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ... |
312-443 |
1.88e-07 |
|
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440663 [Multi-domain] Cd Length: 172 Bit Score: 51.10 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 312 LKPGQRVLDVGCGIGGgdfymaenFDVE-------VVGIDLSINMISLA---LERAigLKCAVEFEVADCTKKVYPDNAF 381
Cdd:COG1041 24 AKEGDTVLDPFCGTGT--------ILIEagllgrrVIGSDIDPKMVEGArenLEHY--GYEDADVIRGDARDLPLADESV 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1280981287 382 DVI-----------YSRDTILHIQDKpaLFRSFYKWVKPGGKILITdyckssgAPSPaFAEYIKQRGYDLHDV 443
Cdd:COG1041 94 DAIvtdppygrsskISGEELLELYEK--ALEEAARVLKPGGRVVIV-------TPRD-IDELLEEAGFKVLER 156
|
|
| TrmA |
COG2265 |
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ... |
46-111 |
1.28e-06 |
|
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 441866 [Multi-domain] Cd Length: 377 Bit Score: 50.56 E-value: 1.28e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1280981287 46 EVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIAldfIEGV---I---KKNESINGhHKNVKFMCADVT 111
Cdd:COG2265 224 AALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIG---VEIVpeaVedaRENARLNG-LKNVEFVAGDLE 291
|
|
| PRK10258 |
PRK10258 |
biotin biosynthesis protein BioC; Provisional |
310-422 |
1.31e-06 |
|
biotin biosynthesis protein BioC; Provisional
Pssm-ID: 182340 [Multi-domain] Cd Length: 251 Bit Score: 49.76 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 310 LDLKPGQR---VLDVGCGIGGGDFYMAENfDVEVVGIDLSINMISLALERaiglKCAVEFEVADCTKKVYPDNAFDVIYS 386
Cdd:PRK10258 35 LAMLPQRKfthVLDAGCGPGWMSRYWRER-GSQVTALDLSPPMLAQARQK----DAADHYLAGDIESLPLATATFDLAWS 109
|
90 100 110
....*....|....*....|....*....|....*.
gi 1280981287 387 RDTILHIQDKPALFRSFYKWVKPGGKILITDYCKSS 422
Cdd:PRK10258 110 NLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGS 145
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
289-415 |
1.50e-06 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 48.65 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 289 VFGPGFVSTGgietTKEFVGKLDLKPGQRVLDVGCGIGG-GDFYMAENFDVEVVGIDLSINMISLALE--RAIGLKcAVE 365
Cdd:COG2813 28 VFSRDRLDIG----TRLLLEHLPEPLGGRVLDLGCGYGViGLALAKRNPEARVTLVDVNARAVELARAnaAANGLE-NVE 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 366 FEVADCTKKVyPDNAFDVIYS----------RDTILHiqdkpALFRSFYKWVKPGGKILI 415
Cdd:COG2813 103 VLWSDGLSGV-PDGSFDLILSnppfhagravDKEVAH-----ALIADAARHLRPGGELWL 156
|
|
| PLN02233 |
PLN02233 |
ubiquinone biosynthesis methyltransferase |
313-455 |
1.96e-06 |
|
ubiquinone biosynthesis methyltransferase
Pssm-ID: 177877 [Multi-domain] Cd Length: 261 Bit Score: 49.50 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 313 KPGQRVLDVGCGIGGGDFYMAENF--DVEVVGIDLSINMISLALERA-----IGLKCaVEFEVADCTKKVYPDNAFDVIY 385
Cdd:PLN02233 72 KMGDRVLDLCCGSGDLAFLLSEKVgsDGKVMGLDFSSEQLAVAASRQelkakSCYKN-IEWIEGDATDLPFDDCYFDAIT 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 386 SRDTILHIQDKPALFRSFYKWVKPGGKILITDYCKSSGAPSPAFAEYIKQR-------GYDLHDVKSY----------GQ 448
Cdd:PLN02233 151 MGYGLRNVVDRLKAMQEMYRVLKPGSRVSILDFNKSTQPFTTSMQEWMIDNvvvpvatGYGLAKEYEYlkssineyltGE 230
|
170
....*....|.
gi 1280981287 449 MLE----EAGF 455
Cdd:PLN02233 231 ELEklalEAGF 241
|
|
| UbiG |
TIGR01983 |
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ... |
303-456 |
3.03e-06 |
|
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273910 Cd Length: 224 Bit Score: 48.44 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 303 TKEFVGKLDlkpGQRVLDVGCGIGGGDFYMAENfDVEVVGIDLSINMISLALERAIGLKCAVEFE---VADCTKKvyPDN 379
Cdd:TIGR01983 38 RKNFKNPLD---GLRVLDVGCGGGLLSEPLARL-GANVTGIDASEENIEVAKLHAKKDPLQIDYRcttVEDLAEK--KAG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 380 AFDVIYSRDTILHIQDKPALFRSFYKWVKPGGKILITDYCKS--SGAPSPAFAEYIKQ---RGydLHDVKSY------GQ 448
Cdd:TIGR01983 112 SFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINRTpkSYLLAIVGAEYILRivpKG--THDWEKFikpselLS 189
|
....*...
gi 1280981287 449 MLEEAGFK 456
Cdd:TIGR01983 190 WLESAGLR 197
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
60-156 |
4.02e-06 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 45.44 E-value: 4.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 60 LELGAGIGRFTGDLAEKA--GQVIALDFIEGVIKKNESINGHHKNVKFMCADVTSPEL-KVSENSVDLIFSNWLLMYLSD 136
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALpgLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLgELDPGSFDVVVASNVLHHLAD 80
|
90 100
....*....|....*....|
gi 1280981287 137 KEVknLAERMVKWLKVGGYI 156
Cdd:pfam08242 81 PRA--VLRNIRRLLKPGGVL 98
|
|
| PTZ00098 |
PTZ00098 |
phosphoethanolamine N-methyltransferase; Provisional |
46-195 |
1.19e-05 |
|
phosphoethanolamine N-methyltransferase; Provisional
Pssm-ID: 173391 [Multi-domain] Cd Length: 263 Bit Score: 46.89 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 46 EVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAG-QVIALDFIEGVIKKNESINGHHKNVKFMCADVTSPELkvSENSVDL 124
Cdd:PTZ00098 43 KILSDIELNENSKVLDIGSGLGGGCKYINEKYGaHVHGVDICEKMVNIAKLRNSDKNKIEFEANDILKKDF--PENTFDM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 125 IFSNWLLMYLSDKEVKNLAERMVKWLKVGGYIFFRESCFHQSGDC---------KRKYNPTHYREprfYTKVFKECHMQD 195
Cdd:PTZ00098 121 IYSRDAILHLSYADKKKLFEKCYKWLKPNGILLITDYCADKIENWdeefkayikKRKYTLIPIQE---YGDLIKSCNFQN 197
|
|
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
311-386 |
3.70e-05 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 45.14 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 311 DLKPGQRVLDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALE--RAIGLKCAVEFEVADCT--KKVYPDNAFDVIY 385
Cdd:COG4123 34 PVKKGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARRnvALNGLEDRITVIHGDLKefAAELPPGSFDLVV 113
|
.
gi 1280981287 386 S 386
Cdd:COG4123 114 S 114
|
|
| COG2263 |
COG2263 |
Predicted RNA methylase [General function prediction only]; |
55-128 |
5.71e-05 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 44.12 E-value: 5.71e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1280981287 55 EGKSVLELGAGIGRFT-GDLAEKAGQVIALD----FIEgVIKKNESinGHHKNVKFMCADVTSPELkvsENSVDLIFSN 128
Cdd:COG2263 45 EGKTVLDLGCGTGMLAiGAALLGAKKVVGVDidpeALE-IARENAE--RLGVRVDFIRADVTRIPL---GGSVDTVVMN 117
|
|
| PRK06202 |
PRK06202 |
hypothetical protein; Provisional |
317-401 |
6.74e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 180466 [Multi-domain] Cd Length: 232 Bit Score: 44.22 E-value: 6.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 317 RVLDVGCgiGGGDF-----YMAE--NFDVEVVGIDLSINMISLALERAIGLKCAVEFEVADCTkkVYPDNAFDVIYSrDT 389
Cdd:PRK06202 63 TLLDIGC--GGGDLaidlaRWARrdGLRLEVTAIDPDPRAVAFARANPRRPGVTFRQAVSDEL--VAEGERFDVVTS-NH 137
|
90
....*....|..
gi 1280981287 390 ILHIQDKPALFR 401
Cdd:PRK06202 138 FLHHLDDAEVVR 149
|
|
| TrmA |
COG2265 |
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ... |
310-384 |
1.39e-04 |
|
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 441866 [Multi-domain] Cd Length: 377 Bit Score: 44.01 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 310 LDLKPGQRVLDVGCGIGGgdF--YMAENFDvEVVGIDLSINMISLALE--RAIGLKcAVEFEVADCTK---KVYPDNAFD 382
Cdd:COG2265 229 LDLTGGERVLDLYCGVGT--FalPLARRAK-KVIGVEIVPEAVEDAREnaRLNGLK-NVEFVAGDLEEvlpELLWGGRPD 304
|
..
gi 1280981287 383 VI 384
Cdd:COG2265 305 VV 306
|
|
| PRK14968 |
PRK14968 |
putative methyltransferase; Provisional |
310-384 |
1.49e-04 |
|
putative methyltransferase; Provisional
Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 42.96 E-value: 1.49e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1280981287 310 LDLKPGQRVLDVGCGIGGGDFYMAENfDVEVVGIDLSINMISLALERAIGLKCA---VEFEVADCTKKVYpDNAFDVI 384
Cdd:PRK14968 19 AVDKKGDRVLEVGTGSGIVAIVAAKN-GKKVVGVDINPYAVECAKCNAKLNNIRnngVEVIRSDLFEPFR-GDKFDVI 94
|
|
| Nnt1 |
COG3897 |
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ... |
314-441 |
1.54e-04 |
|
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443104 [Multi-domain] Cd Length: 216 Bit Score: 42.95 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 314 PGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSinmiSLALErAIGLKCA-----VEFEVADCTKKVyPDNAFDVI---- 384
Cdd:COG3897 70 AGKRVLELGCGLGLVGIAAAKAGAADVTATDYD----PEALA-ALRLNAAlngvaITTRLGDWRDPP-AAGGFDLIlggd 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1280981287 385 --YSRDTILHIqdkPALFRSFykwVKPGGKILITDYckssG-APSPAFAEY-IKQRGYDLH 441
Cdd:COG3897 144 vlYERDLAEPL---LPFLDRL---AAPGGEVLIGDP----GrGYLPAFRERlEALAGYEVV 194
|
|
| PRK07580 |
PRK07580 |
Mg-protoporphyrin IX methyl transferase; Validated |
309-370 |
1.97e-04 |
|
Mg-protoporphyrin IX methyl transferase; Validated
Pssm-ID: 236059 [Multi-domain] Cd Length: 230 Bit Score: 42.90 E-value: 1.97e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1280981287 309 KLDLKPGQRVLDVGCGIGGGDFYMAENfDVEVVGIDLSINMISLALERA--IGLKCAVEFEVAD 370
Cdd:PRK07580 58 ADGDLTGLRILDAGCGVGSLSIPLARR-GAKVVASDISPQMVEEARERApeAGLAGNITFEVGD 120
|
|
| MetW |
pfam07021 |
Methionine biosynthesis protein MetW; This family consists of several bacterial and one ... |
312-390 |
1.98e-04 |
|
Methionine biosynthesis protein MetW; This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalyzed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganizms the reaction is catalyzed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells.
Pssm-ID: 399779 Cd Length: 193 Bit Score: 42.44 E-value: 1.98e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1280981287 312 LKPGQRVLDVGCGIGGGDFYMAENFDVEVVGIDLSINMISLALERAIglkcAVEFEVADCTKKVYPDNAFDVIYSRDTI 390
Cdd:pfam07021 11 IPPGSRVLDLGCGDGTLLYLLKEEKGVDGYGIELDAAGVAECVAKGL----YVIQGDLDEGLEHFPDKSFDYVILSQTL 85
|
|
| TrmR |
COG4122 |
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ... |
312-417 |
2.36e-04 |
|
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443298 Cd Length: 173 Bit Score: 42.09 E-value: 2.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 312 LKPGQRVLDVGCGIGGGDFYMAENF--DVEVVGIDLSINMISLA---LERAiGLKCAVEFEVADCTK--KVYPDNAFDVI 384
Cdd:COG4122 14 LLGAKRILEIGTGTGYSTLWLARALpdDGRLTTIEIDPERAAIArenFARA-GLADRIRLILGDALEvlPRLADGPFDLV 92
|
90 100 110
....*....|....*....|....*....|....*.
gi 1280981287 385 YSrDTilhiqDK---PALFRSFYKWVKPGGkILITD 417
Cdd:COG4122 93 FI-DA-----DKsnyPDYLELALPLLRPGG-LIVAD 121
|
|
| ubiE |
PRK00216 |
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ... |
44-125 |
3.77e-04 |
|
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;
Pssm-ID: 234689 [Multi-domain] Cd Length: 239 Bit Score: 42.06 E-value: 3.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 44 RPEVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAG---QVIALDFIEG---VIKKNESINGHHKNVKFMCADVTspELKV 117
Cdd:PRK00216 40 RRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGktgEVVGLDFSEGmlaVGREKLRDLGLSGNVEFVQGDAE--ALPF 117
|
....*...
gi 1280981287 118 SENSVDLI 125
Cdd:PRK00216 118 PDNSFDAV 125
|
|
| Methyltransf_PK |
pfam05891 |
AdoMet dependent proline di-methyltransferase; This protein is expressed in the tail neuron ... |
15-160 |
3.78e-04 |
|
AdoMet dependent proline di-methyltransferase; This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyzes the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognize the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified. As with other methyltransferases, this family carries the characteriztic GxGxG motif.
Pssm-ID: 461771 Cd Length: 218 Bit Score: 41.98 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 15 KKYWMEHSAglTLEGML--------LDSNASD-----LDKEERPEVlsllppHEGKSVLELGAGIGRFTGDLAEK-AGQV 80
Cdd:pfam05891 10 IDYWEGVSA--TVDGMLggyghvsdIDVNGSRnflrrLLRERLPGK------NRHLVALDCGAGIGRVTKNLLLPlFSKV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 81 IALDFIEGVIKK--NESINGHHKNVKFMCADVT--SPElkvsENSVDLIFSNWLLMYLSDKEVKNLAERMVKWLKVGGYI 156
Cdd:pfam05891 82 DLVEPVEDFIEKakEYLAEGKKKVGNFFCVGLQdfTPE----EGRYDLIWIQWCIGHLTDEDLVAFLKRCKGGLKPNGFI 157
|
....
gi 1280981287 157 FFRE 160
Cdd:pfam05891 158 VVKE 161
|
|
| PRK06922 |
PRK06922 |
class I SAM-dependent methyltransferase; |
310-417 |
4.55e-04 |
|
class I SAM-dependent methyltransferase;
Pssm-ID: 180751 [Multi-domain] Cd Length: 677 Bit Score: 42.93 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 310 LDLKPGQRVLDVGCGigGG---DFYMAENFDVEVVGIDLSINMISlALER---------------AIGLKCAVEFEVADC 371
Cdd:PRK06922 414 LDYIKGDTIVDVGAG--GGvmlDMIEEETEDKRIYGIDISENVID-TLKKkkqnegrswnvikgdAINLSSSFEKESVDT 490
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 372 tkkvypdnafdVIYSrdTILH-----IQDKPALF---------RSFYKWVKPGGKILITD 417
Cdd:PRK06922 491 -----------IVYS--SILHelfsyIEYEGKKFnhevikkglQSAYEVLKPGGRIIIRD 537
|
|
| COG4627 |
COG4627 |
Predicted SAM-depedendent methyltransferase [General function prediction only]; |
368-446 |
4.95e-04 |
|
Predicted SAM-depedendent methyltransferase [General function prediction only];
Pssm-ID: 443666 [Multi-domain] Cd Length: 161 Bit Score: 41.01 E-value: 4.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 368 VADCTKKV-YPDNAFDVIYSRDTILHIQDK--PALFRSFYKWVKPGGKILIT--D---YCKSSGAPSPAFAEYIKQRGYD 439
Cdd:COG4627 33 VGDLTDPLpFPDNSVDAIYSSHVLEHLDYEeaPLALKECYRVLKPGGILRIVvpDlehVARLYLAEYDAALDVAELRLAG 112
|
....*..
gi 1280981287 440 LHDVKSY 446
Cdd:COG4627 113 PIDPLGI 119
|
|
| COG4076 |
COG4076 |
Predicted RNA methylase [General function prediction only]; |
54-157 |
5.99e-04 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 443253 [Multi-domain] Cd Length: 230 Bit Score: 41.56 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 54 HEGKSVLELGAGIGRFTGdLAEKAG--QVIALD---FIEGVIKKNESINGHHKNVKFMCADVTSPELK------VSEnsv 122
Cdd:COG4076 34 KPGDVVLDIGTGSGLLSM-LAARAGakKVYAVEvnpDIAAVARRIIAANGLSDRITVINADATDLDLPekadviISE--- 109
|
90 100 110
....*....|....*....|....*....|....*
gi 1280981287 123 dlIFSNWLlmyLSDKEVKNLAERMVKWLKVGGYIF 157
Cdd:COG4076 110 --MLDTAL---LDEGQVPILNHARKRLLKPGGRII 139
|
|
| PRK01683 |
PRK01683 |
trans-aconitate 2-methyltransferase; Provisional |
312-411 |
6.25e-04 |
|
trans-aconitate 2-methyltransferase; Provisional
Pssm-ID: 234970 Cd Length: 258 Bit Score: 41.47 E-value: 6.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 312 LKPGQRVLDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALERAIGlkcaVEFEVADCTKKVyPDNAFDVIYSRDTI 390
Cdd:PRK01683 29 LENPRYVVDLGCGPGNSTELLVERWpAARITGIDSSPAMLAEARSRLPD----CQFVEADIASWQ-PPQALDLIFANASL 103
|
90 100
....*....|....*....|.
gi 1280981287 391 LHIQDKPALFRSFYKWVKPGG 411
Cdd:PRK01683 104 QWLPDHLELFPRLVSLLAPGG 124
|
|
| MTS |
pfam05175 |
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
292-415 |
7.12e-04 |
|
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.
Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 40.65 E-value: 7.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 292 PGFVSTGGIET-TKEFVGKLDLKPGQRVLDVGCGIGG-GDFYMAENFDVEVVGIDlsINMISLALER----AIGLKcAVE 365
Cdd:pfam05175 8 PGVFSHGRLDIgSRLLLEHLPKDLSGKVLDLGCGAGVlGAALAKESPDAELTMVD--INARALESARenlaANGLE-NGE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1280981287 366 FEVADCTKKVyPDNAFDVIYS-------RDTILHIQDkpALFRSFYKWVKPGGKILI 415
Cdd:pfam05175 85 VVASDVYSGV-EDGKFDLIISnppfhagLATTYNVAQ--RFIADAKRHLRPGGELWI 138
|
|
| arsM |
PRK11873 |
arsenite methyltransferase; |
54-154 |
8.03e-04 |
|
arsenite methyltransferase;
Pssm-ID: 237007 [Multi-domain] Cd Length: 272 Bit Score: 41.47 E-value: 8.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 54 HEGKSVLELGAGIGrFTGDLAEKA----GQVIALDFIEGVI---KKNESINGHhKNVKFMCADVTspELKVSENSVDLIF 126
Cdd:PRK11873 76 KPGETVLDLGSGGG-FDCFLAARRvgptGKVIGVDMTPEMLakaRANARKAGY-TNVEFRLGEIE--ALPVADNSVDVII 151
|
90 100
....*....|....*....|....*...
gi 1280981287 127 SNWLLMYLSDKEvKNLAErMVKWLKVGG 154
Cdd:PRK11873 152 SNCVINLSPDKE-RVFKE-AFRVLKPGG 177
|
|
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
52-128 |
1.40e-03 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 40.51 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 52 PPHEGKSVLELGAGIG--------RFtgdlaeKAGQVIALDFIEGVI---KKNESINGHHKNVKFMCADVTSPELKVSEN 120
Cdd:COG4123 34 PVKKGGRVLDLGTGTGvialmlaqRS------PGARITGVEIQPEAAelaRRNVALNGLEDRITVIHGDLKEFAAELPPG 107
|
....*...
gi 1280981287 121 SVDLIFSN 128
Cdd:COG4123 108 SFDLVVSN 115
|
|
| Pcm |
COG2518 |
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ... |
310-385 |
1.89e-03 |
|
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 442008 [Multi-domain] Cd Length: 197 Bit Score: 39.69 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 310 LDLKPGQRVLDVGCGIGggdfY----MAENFDvEVVGIDLSINMISLALER--AIGLKcAVEFEVADCTkKVYPDNA-FD 382
Cdd:COG2518 62 LDLKPGDRVLEIGTGSG----YqaavLARLAG-RVYSVERDPELAERARERlaALGYD-NVTVRVGDGA-LGWPEHApFD 134
|
...
gi 1280981287 383 VIY 385
Cdd:COG2518 135 RII 137
|
|
| RsmA |
COG0030 |
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ... |
31-147 |
2.25e-03 |
|
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 439801 [Multi-domain] Cd Length: 270 Bit Score: 40.11 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 31 LLDSNAsdLDKeerpeVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIA--LDfiEGVIKKNESINGHHKNVKFMCA 108
Cdd:COG0030 20 LIDPNI--IRR-----IVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAveID--RRLAAILRETFAAYPNLTVIEG 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1280981287 109 DVtspeLKVSENSVDL-----IFSN-----------WLLMYLSD---------KEVknlAERMV 147
Cdd:COG0030 91 DA----LKVDLPALAAgeplkVVGNlpynistpilfKLLEARPPiedavlmvqKEV---AERLV 147
|
|
| rADc |
smart00650 |
Ribosomal RNA adenine dimethylases; |
46-147 |
2.27e-03 |
|
Ribosomal RNA adenine dimethylases;
Pssm-ID: 128898 Cd Length: 169 Bit Score: 39.03 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 46 EVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIAL----DFIEGVIKKNEsingHHKNVK-----FMCADVTS-PEL 115
Cdd:smart00650 4 KIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIeidpRLAPRLREKFA----AADNLTvihgdALKFDLPKlQPY 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1280981287 116 KVSEN-----SVDLIFsnWLL--------MYL-SDKEVknlAERMV 147
Cdd:smart00650 80 KVVGNlpyniSTPILF--KLLeeppafrdAVLmVQKEV---ARRLA 120
|
|
| PRK14103 |
PRK14103 |
trans-aconitate 2-methyltransferase; Provisional |
305-413 |
2.68e-03 |
|
trans-aconitate 2-methyltransferase; Provisional
Pssm-ID: 184509 Cd Length: 255 Bit Score: 39.67 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 305 EFVGKLDLKPGQRVLDVGCGIGGGDFYMAENF-DVEVVGIDLSINMISLALERAIGlkcAVEFEVADCTkkvyPDNAFDV 383
Cdd:PRK14103 20 DLLARVGAERARRVVDLGCGPGNLTRYLARRWpGAVIEALDSSPEMVAAARERGVD---ARTGDVRDWK----PKPDTDV 92
|
90 100 110
....*....|....*....|....*....|
gi 1280981287 384 IYSRDTILHIQDKPALFRSFYKWVKPGGKI 413
Cdd:PRK14103 93 VVSNAALQWVPEHADLLVRWVDELAPGSWI 122
|
|
| MeTrc |
smart00138 |
Methyltransferase, chemotaxis proteins; Methylates methyl-accepting chemotaxis proteins to ... |
330-415 |
3.83e-03 |
|
Methyltransferase, chemotaxis proteins; Methylates methyl-accepting chemotaxis proteins to form gamma-glutamyl methyl ester residues.
Pssm-ID: 214534 [Multi-domain] Cd Length: 264 Bit Score: 39.19 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 330 FYMAENFDVEVVGIDLSINMISLA-----LERAIG-----------------------LKCAVEFEVADCTKKVYPDNAF 381
Cdd:smart00138 125 LPKGREPDVKILATDIDLKALEKAragiyPERELEdlpkallaryfkevedkyrvkpeLKERVRFAKHNLLAESPPLGDF 204
|
90 100 110
....*....|....*....|....*....|....*.
gi 1280981287 382 DVIYSRDTILHI--QDKPALFRSFYKWVKPGGKILI 415
Cdd:smart00138 205 DLIFCRNVLIYFdePTQRKLLNRFAEALKPGGYLFL 240
|
|
| COG2263 |
COG2263 |
Predicted RNA methylase [General function prediction only]; |
314-391 |
4.57e-03 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 38.35 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 314 PGQRVLDVGCGIG----GGDFYMAEnfdvEVVGIDLSINMISLALERAIGLKCAVEFEVADCTKkvypdnaFDVIYSRDT 389
Cdd:COG2263 45 EGKTVLDLGCGTGmlaiGAALLGAK----KVVGVDIDPEALEIARENAERLGVRVDFIRADVTR-------IPLGGSVDT 113
|
..
gi 1280981287 390 IL 391
Cdd:COG2263 114 VV 115
|
|
| rumA |
PRK13168 |
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; |
310-370 |
4.59e-03 |
|
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
Pssm-ID: 237291 [Multi-domain] Cd Length: 443 Bit Score: 39.37 E-value: 4.59e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 310 LDLKPGQRVLDVGCGIGggdfymaeNFDV-------EVVGIDLSINMISLALERAI--GLKcAVEFEVAD 370
Cdd:PRK13168 293 LDPQPGDRVLDLFCGLG--------NFTLplarqaaEVVGVEGVEAMVERARENARrnGLD-NVTFYHAN 353
|
|
| PRK11207 |
PRK11207 |
tellurite resistance methyltransferase TehB; |
45-155 |
4.96e-03 |
|
tellurite resistance methyltransferase TehB;
Pssm-ID: 183040 Cd Length: 197 Bit Score: 38.56 E-value: 4.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 45 PEVLSLLPPHEGKSVLELGAGIGRFTGDLAEKAGQVIALD----FIEGV--IKKNESINGHHKNVKfmcaDVTSPELkvs 118
Cdd:PRK11207 20 SEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGFDVTAWDknpmSIANLerIKAAENLDNLHTAVV----DLNNLTF--- 92
|
90 100 110
....*....|....*....|....*....|....*..
gi 1280981287 119 ENSVDLIFSNWLLMYLSDKEVKNLAERMVKWLKVGGY 155
Cdd:PRK11207 93 DGEYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGY 129
|
|
| Nnt1 |
COG3897 |
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ... |
43-151 |
4.99e-03 |
|
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443104 [Multi-domain] Cd Length: 216 Bit Score: 38.71 E-value: 4.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 43 ERPEVlsllpphEGKSVLELGAGIGrFTGDLAEKAG--QVIALDFIEGV---IKKNESINGHHknVKFMCADVTSPELkv 117
Cdd:COG3897 65 DHPEV-------AGKRVLELGCGLG-LVGIAAAKAGaaDVTATDYDPEAlaaLRLNAALNGVA--ITTRLGDWRDPPA-- 132
|
90 100 110
....*....|....*....|....*....|....*..
gi 1280981287 118 sENSVDLIFsnwllmyLSDkeV---KNLAERMVKWLK 151
Cdd:COG3897 133 -AGGFDLIL-------GGD--VlyeRDLAEPLLPFLD 159
|
|
| trmB |
PRK00121 |
tRNA (guanine-N(7)-)-methyltransferase; Reviewed |
59-158 |
7.06e-03 |
|
tRNA (guanine-N(7)-)-methyltransferase; Reviewed
Pssm-ID: 234649 Cd Length: 202 Bit Score: 37.83 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 59 VLELGAGIGRFTGDLAEKAGQV--IALD-FIEGVIKKNESINGHH-KNVKFMCADVTSP-ELKVSENSVD---LIFSN-W 129
Cdd:PRK00121 44 HLEIGFGKGEFLVEMAKANPDInfIGIEvHEPGVGKALKKIEEEGlTNLRLLCGDAVEVlLDMFPDGSLDriyLNFPDpW 123
|
90 100 110
....*....|....*....|....*....|....*..
gi 1280981287 130 L--------LMYlsdkevKNLAERMVKWLKVGGYIFF 158
Cdd:PRK00121 124 PkkrhhkrrLVQ------PEFLALYARKLKPGGEIHF 154
|
|
| Gcd14 |
COG2519 |
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ... |
307-419 |
9.59e-03 |
|
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 442009 [Multi-domain] Cd Length: 249 Bit Score: 37.83 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280981287 307 VGKLDLKPGQRVLDVGCGIGGGDFYMAeNFdV----EVVGIDLSINMISLALE--RAIGLKCAVEFEVADcTKKVYPDNA 380
Cdd:COG2519 84 IARLDIFPGARVLEAGTGSGALTLALA-RA-VgpegKVYSYERREDFAEIARKnlERFGLPDNVELKLGD-IREGIDEGD 160
|
90 100 110
....*....|....*....|....*....|....*....
gi 1280981287 381 FDVIysrdtILHIQDKPALFRSFYKWVKPGGKILItdYC 419
Cdd:COG2519 161 VDAV-----FLDMPDPWEALEAVAKALKPGGVLVA--YV 192
|
|
| |
