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Conserved domains on  [gi|1281005087|ref|XP_022986464|]
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transducin beta-like protein 3 [Cucurbita maxima]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 16652346)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-607 1.54e-69

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.96  E-value: 1.54e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  26 VVSSDASFIACACGDSIKIVDADTAAIRSTVEGGESEVFTALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHDGP 105
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 106 VMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWDLMSKKCIATL 185
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 186 -GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTvltyevleavlviksgsdfascvgsssqkrketsvssei 264
Cdd:COG2319   159 tGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--------------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 265 yfitvgergvvrlwssesavclfeqkssdvstkmdeqnmgftaavllpsdrgllcvtadqqfifyspvktlggeisltts 344
Cdd:COG2319       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 345 krligyneeivdmkflgddeqflavatnvehirvydvasmscsfiLAGHTDIVLCLdsCVSSSGTTLiVTGSKDNNVRLW 424
Cdd:COG2319   200 ---------------------------------------------LTGHTGAVRSV--AFSPDGKLL-ASGSADGTVRLW 231

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 425 EAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWSFDGLsedankpinlKAKAIVAAHDKDINSIAVAPND 504
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATG----------ELLRTLTGHSGGVNSVAFSPDG 300

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 505 SLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRASF 584
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         570       580
                  ....*....|....*....|...
gi 1281005087 585 LTRGTQLVSCGADGSVMLWTVKT 607
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 668-798 1.69e-54

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


:

Pssm-ID: 462540  Cd Length: 139  Bit Score: 185.02  E-value: 1.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 668 QELENAVSDADYAKAIQIAFDLRRPHRLFELFSELCSKNDYDNH------VGKTLGALGKEDFRLLFEYLREWNTKPKLC 741
Cdd:pfam08625   2 QELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKTS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1281005087 742 HVAQFVLFRAFSILPPTEITEIKGIGELLEGLIPYSQRHFSRIDRLVRSSFLLDYTL 798
Cdd:pfam08625  82 HVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTL 138
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-607 1.54e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.96  E-value: 1.54e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  26 VVSSDASFIACACGDSIKIVDADTAAIRSTVEGGESEVFTALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHDGP 105
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 106 VMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWDLMSKKCIATL 185
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 186 -GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTvltyevleavlviksgsdfascvgsssqkrketsvssei 264
Cdd:COG2319   159 tGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--------------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 265 yfitvgergvvrlwssesavclfeqkssdvstkmdeqnmgftaavllpsdrgllcvtadqqfifyspvktlggeisltts 344
Cdd:COG2319       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 345 krligyneeivdmkflgddeqflavatnvehirvydvasmscsfiLAGHTDIVLCLdsCVSSSGTTLiVTGSKDNNVRLW 424
Cdd:COG2319   200 ---------------------------------------------LTGHTGAVRSV--AFSPDGKLL-ASGSADGTVRLW 231

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 425 EAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWSFDGLsedankpinlKAKAIVAAHDKDINSIAVAPND 504
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATG----------ELLRTLTGHSGGVNSVAFSPDG 300

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 505 SLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRASF 584
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         570       580
                  ....*....|....*....|...
gi 1281005087 585 LTRGTQLVSCGADGSVMLWTVKT 607
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-645 1.30e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 1.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 344 SKRLIGYNEEIVDMKFLgDDEQFLAVATNVEHIRVYDVASMSCSFILAGHTDIVLCldsCVSSSGTTLIVTGSKDNNVRL 423
Cdd:cd00200     2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 424 WEAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWSFDglsedankpiNLKAKAIVAAHDKDINSIAVAPN 503
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 504 DSLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRAS 583
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1281005087 584 FLTRGTQLVSCGADGSVMLWTVKTEERIAVYDQHEDKIWALAVGKKTEMLATGGSDAAVNLW 645
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 668-798 1.69e-54

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 185.02  E-value: 1.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 668 QELENAVSDADYAKAIQIAFDLRRPHRLFELFSELCSKNDYDNH------VGKTLGALGKEDFRLLFEYLREWNTKPKLC 741
Cdd:pfam08625   2 QELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKTS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1281005087 742 HVAQFVLFRAFSILPPTEITEIKGIGELLEGLIPYSQRHFSRIDRLVRSSFLLDYTL 798
Cdd:pfam08625  82 HVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTL 138
WD40 pfam00400
WD domain, G-beta repeat;
135-175 1.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1281005087 135 GFCTHYFTGHKGVVSSILFHPDPNkqLLFSGSEDGSVRVWD 175
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-175 1.43e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1281005087  137 CTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWD 175
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 72-218 3.78e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  72 NDEFLFSAGHSRQIRVWDL-------STMKCVRSWKGHDGPVMGMNCHLSG-GLLATAGADRKVLVWDVDGGFCTHYFTG 143
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 144 HKGVVSSILFHPDPNkqLLFSGSEDGSVRVWDLMSKKCIATLG-HESTVTSFAIsedgW-----TLLSAGRDKV----VN 213
Cdd:PTZ00421  167 HSDQITSLEWNLDGS--LLCTTSKDKKLNIIDPRDGTIVSSVEaHASAKSQRCL----WakrkdLIITLGCSKSqqrqIM 240


                  ....*
gi 1281005087 214 VWNLR 218
Cdd:PTZ00421  241 LWDTR 245
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-607 1.54e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.96  E-value: 1.54e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  26 VVSSDASFIACACGDSIKIVDADTAAIRSTVEGGESEVFTALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHDGP 105
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 106 VMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWDLMSKKCIATL 185
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLATGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 186 -GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTvltyevleavlviksgsdfascvgsssqkrketsvssei 264
Cdd:COG2319   159 tGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--------------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 265 yfitvgergvvrlwssesavclfeqkssdvstkmdeqnmgftaavllpsdrgllcvtadqqfifyspvktlggeisltts 344
Cdd:COG2319       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 345 krligyneeivdmkflgddeqflavatnvehirvydvasmscsfiLAGHTDIVLCLdsCVSSSGTTLiVTGSKDNNVRLW 424
Cdd:COG2319   200 ---------------------------------------------LTGHTGAVRSV--AFSPDGKLL-ASGSADGTVRLW 231

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 425 EAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWSFDGLsedankpinlKAKAIVAAHDKDINSIAVAPND 504
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATG----------ELLRTLTGHSGGVNSVAFSPDG 300

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 505 SLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRASF 584
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         570       580
                  ....*....|....*....|...
gi 1281005087 585 LTRGTQLVSCGADGSVMLWTVKT 607
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
68-645 1.76e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.09  E-value: 1.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  68 ALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHDGPVMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGV 147
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 148 VSSILFHPDPnkQLLFSGSEDGSVRVWDLMSKKCIATL-GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTv 226
Cdd:COG2319    81 VLSVAFSPDG--RLLASASADGTVRLWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 227 ltyevleavlviksgsdfascvgsssqkrketsvsseiyfitvgergvvrlwssesavclfeqkssdvstkmdeqnmgft 306
Cdd:COG2319       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 307 aavllpsdrgllcvtadqqfifyspvktlggeislttskrligyneeivdmkflgddeqflavatnvehirvydvasmsc 386
Cdd:COG2319       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 387 sfiLAGHTDIVLCLDscVSSSGTTLiVTGSKDNNVRLWEAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKV 466
Cdd:COG2319   158 ---LTGHSGAVTSVA--FSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 467 WSFDGlsedaNKPInlkakAIVAAHDKDINSIAVAPNDSLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVD 546
Cdd:COG2319   231 WDLAT-----GKLL-----RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 547 QCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRASFLTRGTQLVSCGADGSVMLWTVKTEERIAVYDQHEDKIWALAV 626
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         570
                  ....*....|....*....
gi 1281005087 627 GKKTEMLATGGSDAAVNLW 645
Cdd:COG2319   381 SPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
24-565 2.15e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 213.62  E-value: 2.15e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  24 AFVVSSDASFIACACGDSIKIVDADTAAIRSTVEGGESEVfTALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHD 103
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV-LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 104 GPVMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWDLMSKKCIA 183
Cdd:COG2319   121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 184 TL-GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTvltyevleavlviksgsdfascvgsssqkrketsvss 262
Cdd:COG2319   199 TLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT------------------------------------- 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 263 eiyfitvgergvvrlwssesavclfeqkssdvstkmdeqnmgftaavllpsdrgllcvtadqqfifyspvktlggeislt 342
Cdd:COG2319       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 343 tskrligyneeivdmkflgddeqflavatnvehirvydvasmscsfiLAGHTDIVLCLDscVSSSGTTLiVTGSKDNNVR 422
Cdd:COG2319   242 -----------------------------------------------LTGHSGSVRSVA--FSPDGRLL-ASGSADGTVR 271

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 423 LWEAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWSFDglsedankpiNLKAKAIVAAHDKDINSIAVAP 502
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLA----------TGKLLRTLTGHTGAVRSVAFSP 340

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1281005087 503 NDSLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWAISD 565
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-645 1.30e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 1.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 344 SKRLIGYNEEIVDMKFLgDDEQFLAVATNVEHIRVYDVASMSCSFILAGHTDIVLCldsCVSSSGTTLIVTGSKDNNVRL 423
Cdd:cd00200     2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD---VAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 424 WEAESKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWSFDglsedankpiNLKAKAIVAAHDKDINSIAVAPN 503
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 504 DSLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRAS 583
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1281005087 584 FLTRGTQLVSCGADGSVMLWTVKTEERIAVYDQHEDKIWALAVGKKTEMLATGGSDAAVNLW 645
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 386-645 7.10e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 194.48  E-value: 7.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 386 CSFILAGHTDIVLCLDScvsSSGTTLIVTGSKDNNVRLWEAESKTCIGVGVGHMGAVGAVAFSKkRRDFFVSGSSDRTLK 465
Cdd:cd00200     1 LRRTLKGHTGGVTCVAF---SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 466 VWSFDGlsedaNKPINlkakaIVAAHDKDINSIAVAPNDSLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPV 545
Cdd:cd00200    77 LWDLET-----GECVR-----TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 546 DQCVVTASGDKTIKIWAISDGSCLKTFEGHMSSVLRASFLTRGTQLVSCGADGSVMLWTVKTEERIAVYDQHEDKIWALA 625
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260
                  ....*....|....*....|
gi 1281005087 626 VGKKTEMLATGGSDAAVNLW 645
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVW 246
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 668-798 1.69e-54

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 185.02  E-value: 1.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 668 QELENAVSDADYAKAIQIAFDLRRPHRLFELFSELCSKNDYDNH------VGKTLGALGKEDFRLLFEYLREWNTKPKLC 741
Cdd:pfam08625   2 QELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKTS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1281005087 742 HVAQFVLFRAFSILPPTEITEIKGIGELLEGLIPYSQRHFSRIDRLVRSSFLLDYTL 798
Cdd:pfam08625  82 HVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTL 138
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-562 9.87e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 185.62  E-value: 9.87e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  95 CVRSWKGHDGPVMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVW 174
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD--GTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 175 DLMSKKCIATL-GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTvltyevleavlviksgsdfascvgsssq 253
Cdd:cd00200    79 DLETGECVRTLtGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---------------------------- 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 254 krketsvsseiyfitvgergvvrlwssesavclfeqkssdvstkmdeqnmgftaavllpsdrgllcvtadqqfifyspvk 333
Cdd:cd00200       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 334 tlggeislttskrligyneeivdmkflgddeqflavatnvehirvydvasmscsfiLAGHTDIVLCLdsCVSSSGtTLIV 413
Cdd:cd00200   131 --------------------------------------------------------LRGHTDWVNSV--AFSPDG-TFVA 151

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 414 TGSKDNNVRLWEAESKTCIGVGVGHMGAVGAVAFSKKRRDfFVSGSSDRTLKVWSFDGlsedankpinLKAKAIVAAHDK 493
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLST----------GKCLGTLRGHEN 220

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1281005087 494 DINSIAVAPNDSLVCSGSQDRTACVWRLPDLVSVVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIWA 562
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-425 2.70e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.99  E-value: 2.70e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  53 RSTVEGGESEVfTALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHDGPVMGMNCHLSGGLLATAGADRKVLVWDV 132
Cdd:cd00200     2 RRTLKGHTGGV-TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 133 DGGFCTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWDLMSKKCIATL-GHESTVTSFAISEDGWTLLSAGRDKV 211
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 212 VNVWNLRNYSCKKTVLTYE-VLEAVLVIKSGSDFASCVGSSSqkrketsvsseiyfitvgergvVRLWSSESAVCLfeqk 290
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTgEVNSVAFSPDGEKLLSSSSDGT----------------------IKLWDLSTGKCL---- 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 291 ssdvstkmdeqnmgftaavllpsdrgllcvtadqqfifyspvktlggeislttsKRLIGYNEEIVDMKFLGDDeQFLAVA 370
Cdd:cd00200   213 ------------------------------------------------------GTLRGHENGVNSVAFSPDG-YLLASG 237

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1281005087 371 TNVEHIRVYDVASMSCSFILAGHTDIVLCLdsCVSSSGTTLIvTGSKDNNVRLWE 425
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSL--AWSPDGKRLA-SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-279 7.35e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.36  E-value: 7.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  23 GAFVVSSDASFIACACGDS-IKIVDADTAAIRSTVEGGESEVFtALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKG 101
Cdd:cd00200    55 RDVAASADGTYLASGSSDKtIRLWDLETGECVRTLTGHTSYVS-SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 102 HDGPVMGMNCHLSGGLLATAGADRKVLVWDVDGGFCTHYFTGHKGVVSSILFHPDPNKqlLFSGSEDGSVRVWDLMSKKC 181
Cdd:cd00200   134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK--LLSSSSDGTIKLWDLSTGKC 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 182 IATL-GHESTVTSFAISEDGWTLLSAGRDKVVNVWNLRNYSCKKTvltyevleavlvIKSGSDFASCVGSSsqkrketsv 260
Cdd:cd00200   212 LGTLrGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT------------LSGHTNSVTSLAWS--------- 270

                         250
                  ....*....|....*....
gi 1281005087 261 SSEIYFITVGERGVVRLWS 279
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
135-175 1.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1281005087 135 GFCTHYFTGHKGVVSSILFHPDPNkqLLFSGSEDGSVRVWD 175
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-175 1.43e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1281005087  137 CTHYFTGHKGVVSSILFHPDpnKQLLFSGSEDGSVRVWD 175
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 7.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 7.66e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1281005087   92 TMKCVRSWKGHDGPVMGMNCHLSGGLLATAGADRKVLVWD 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 527-561 9.69e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 9.69e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1281005087  527 VVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIW 561
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
527-561 1.91e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1281005087 527 VVVLRGHKRGIWSVEFSPVDQCVVTASGDKTIKIW 561
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 565-603 2.82e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.82e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1281005087  565 DGSCLKTFEGHMSSVLRASFLTRGTQLVSCGADGSVMLW 603
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 72-218 3.78e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  72 NDEFLFSAGHSRQIRVWDL-------STMKCVRSWKGHDGPVMGMNCHLSG-GLLATAGADRKVLVWDVDGGFCTHYFTG 143
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 144 HKGVVSSILFHPDPNkqLLFSGSEDGSVRVWDLMSKKCIATLG-HESTVTSFAIsedgW-----TLLSAGRDKV----VN 213
Cdd:PTZ00421  167 HSDQITSLEWNLDGS--LLCTTSKDKKLNIIDPRDGTIVSSVEaHASAKSQRCL----WakrkdLIITLGCSKSqqrqIM 240


                  ....*
gi 1281005087 214 VWNLR 218
Cdd:PTZ00421  241 LWDTR 245
PTZ00421 PTZ00421
coronin; Provisional
 143-262 6.68e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 143 GHKGVVSSILFHP-DPNKqlLFSGSEDGSVRVWDL----MSKKCIATL----GHESTV--TSFAISEDGwTLLSAGRDKV 211
Cdd:PTZ00421   73 GQEGPIIDVAFNPfDPQK--LFTASEDGTIMGWGIpeegLTQNISDPIvhlqGHTKKVgiVSFHPSAMN-VLASAGADMV 149

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1281005087 212 VNVWNLrnysckktvltyEVLEAVLVIKSGSDFAS-----------CVGSSSQK------RKETSVSS 262
Cdd:PTZ00421  150 VNVWDV------------ERGKAVEVIKCHSDQITslewnldgsllCTTSKDKKlniidpRDGTIVSS 205
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 61-219 8.60e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 8.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  61 SEVFTALALSPNDEFLFSAGHSRQIRVWDLSTMkcVRSWKGHDGPVMGM--NCHLSG--------GLLATAGADRKVLVW 130
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESI--IKDGRDIHYPVVELasRSKLSGicwnsyikSQVASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 131 DVDGGFCTHYFTGHKGVVSSILFHP-DPNkqLLFSGSEDGSVRVWDLMSKKCIATLGHESTVTSFAI-SEDGWTLLSAGR 208
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRVWSIDYSSaDPT--LLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAFGSA 638

                         170
                  ....*....|.
gi 1281005087 209 DKVVNVWNLRN 219
Cdd:PLN00181  639 DHKVYYYDLRN 649
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-216 1.28e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1281005087  178 SKKCIATL-GHESTVTSFAISEDGWTLLSAGRDKVVNVWN 216
Cdd:smart00320   1 SGELLKTLkGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
93-131 2.12e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.12e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1281005087  93 MKCVRSWKGHDGPVMGMNCHLSGGLLATAGADRKVLVWD 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
566-603 2.79e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1281005087 566 GSCLKTFEGHMSSVLRASFLTRGTQLVSCGADGSVMLW 603
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 85-217 3.14e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  85 IRVWDLSTMKCVRSWKGHDGPVMGMNCHLSG-GLLATAGADRKVLVWDVDGGFCTHYFTGhKGVVSSILFHPDPNKQLLF 163
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAF 635

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1281005087 164 sGSEDGSVRVWDLMSKK---CiATLGHESTVtSFAISEDGWTLLSAGRDKVVNVWNL 217
Cdd:PLN00181  636 -GSADHKVYYYDLRNPKlplC-TMIGHSKTV-SYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 383-425 1.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1281005087  383 SMSCSFILAGHTDIVLCLdsCVSSSGTtLIVTGSKDNNVRLWE 425
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV--AFSPDGK-YLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
33-209 1.73e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  33 FIACACGDSIKIVDADTAAIRSTVEGGESevFTALALSPNDEFLF-SAGHSRQIRVWDLSTMKCVRSWKGHDGPVMgmnc 111
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVGGG--PRGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVATIPVGAGPHG---- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 112 hlsggllatagadrkvlvwdvdggfcthyftghkgvvssILFHPDpNKQLLFSGSEDGS----VRVWDLMSKKCIATLGH 187
Cdd:COG3391   157 ---------------------------------------IAVDPD-GKRLYVANSGSNTvsviVSVIDTATGKVVATIPV 196

                         170       180
                  ....*....|....*....|..
gi 1281005087 188 ESTVTSFAISEDGWTLLSAGRD 209
Cdd:COG3391   197 GGGPVGVAVSPDGRRLYVANRG 218
WD40 pfam00400
WD domain, G-beta repeat;
490-519 4.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.60e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1281005087 490 AHDKDINSIAVAPNDSLVCSGSQDRTACVW 519
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 481-519 4.76e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1281005087  481 NLKAKAIVAAHDKDINSIAVAPNDSLVCSGSQDRTACVW 519
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
429-468 5.43e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1281005087 429 KTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWS 468
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
384-425 5.43e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1281005087 384 MSCSFILAGHTDIVLCLDScvsSSGTTLIVTGSKDNNVRLWE 425
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 428-468 6.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1281005087  428 SKTCIGVGVGHMGAVGAVAFSKKRRdFFVSGSSDRTLKVWS 468
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-216 7.45e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1281005087 179 KKCIATL-GHESTVTSFAISEDGWTLLSAGRDKVVNVWN 216
Cdd:pfam00400   1 GKLLKTLeGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 34-204 1.09e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.21  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  34 IACACGdSIKIVDADTAAIRSTVEGGESEV-------FTALALspNDEFLFSAGHSRQIRVWDLS--TMKCVRS--WKGH 102
Cdd:cd22857    49 VARKNG-TVEVLDPENGDLLASFSDSEPATklseedhFVGLHL--FSGTLLTCTSKGSLRSTKLPddSTASSSPtaWVCL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087 103 DGPVMGMNCHLSGGLLATAGADRKVLVWDVDgGFCTHYFTGhKGV------------VSSILFHPDPNKQLLFSGSEDGS 170
Cdd:cd22857   126 GGNLLCMRVDPNENYFAFGGKEVELNVWDLE-EKPGKIWRA-KNVpndslglrvpvwVTDLTFLSKDDHRKIVTGTGYHQ 203

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1281005087 171 VRVWDLMSKK--CIATLGHESTVTSFAISEDGWTLL 204
Cdd:cd22857   204 VRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTVY 239
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 48-135 2.04e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.44  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281005087  48 DTAAIR---STVEGGESEVfTALALSPNDEFLFSAGHSRQIRVWDLSTMKCVRSWKGHDGPVMGM-NCHLSGGLLATAGA 123
Cdd:cd22857   208 DTRAQRrpvVSVDFGETPI-KAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGGSIRSiARHPELPLIASCGL 286

                          90
                  ....*....|..
gi 1281005087 124 DRKVLVWDVDGG 135
Cdd:cd22857   287 DRYLRIWDTETR 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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