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Conserved domains on  [gi|1280997154|ref|XP_022982283|]
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transcription factor MYB44-like [Cucurbita maxima]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 999994)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 39-152 1.52e-31

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 119.70  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280997154  39 KGPWSAEEDRVLTRLVERYGPRNWSLISRYVK-GRSGKSCRLRWCNQLCPGVEHRPFSPAEDEAIIAAHSRYGNRWATIA 117
Cdd:PLN03091   14 KGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGlQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQIA 93

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1280997154 118 RLLPGRTDNAVKNHWNSTLKRRVRDQGKSAVDHSS 152
Cdd:PLN03091   94 AQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 39-152 1.52e-31

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 119.70  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280997154  39 KGPWSAEEDRVLTRLVERYGPRNWSLISRYVK-GRSGKSCRLRWCNQLCPGVEHRPFSPAEDEAIIAAHSRYGNRWATIA 117
Cdd:PLN03091   14 KGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGlQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQIA 93

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1280997154 118 RLLPGRTDNAVKNHWNSTLKRRVRDQGKSAVDHSS 152
Cdd:PLN03091   94 AQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 36-139 7.19e-20

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 87.54  E-value: 7.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280997154  36 DKIKGPWSAEEDRVLTRLVERYGPRNWSLISRYVKGRSGKSCRLRWCNQLCPGVEHRPFSPAEDEAIIAAHSRYGNRWAT 115
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|....
gi 1280997154 116 IARLLPGRTDNAVKNHWNSTLKRR 139
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDL 120
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 93-136 1.85e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 67.91  E-value: 1.85e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1280997154  93 PFSPAEDEAIIAAHSRYGNRWATIARLLPGRTDNAVKNHWNSTL 136
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 41-83 1.04e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.67  E-value: 1.04e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1280997154  41 PWSAEEDRVLTRLVERYGPRNWSLISRYVKGRSGKSCRLRWCN 83
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRN 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
39-83 1.09e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 65.71  E-value: 1.09e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1280997154   39 KGPWSAEEDRVLTRLVERYGPRNWSLISRYVKGRSGKSCRLRWCN 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRN 45
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 39-152 1.52e-31

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 119.70  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280997154  39 KGPWSAEEDRVLTRLVERYGPRNWSLISRYVK-GRSGKSCRLRWCNQLCPGVEHRPFSPAEDEAIIAAHSRYGNRWATIA 117
Cdd:PLN03091   14 KGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGlQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQIA 93

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1280997154 118 RLLPGRTDNAVKNHWNSTLKRRVRDQGKSAVDHSS 152
Cdd:PLN03091   94 AQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 39-150 1.98e-26

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 102.46  E-value: 1.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280997154  39 KGPWSAEEDRVLTRLVERYGPRNW-SLISRYVKGRSGKSCRLRWCNQLCPGVEHRPFSPAEDEAIIAAHSRYGNRWATIA 117
Cdd:PLN03212   25 RGPWTVEEDEILVSFIKKEGEGRWrSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1280997154 118 RLLPGRTDNAVKNHWNSTLKRRVRDQGKSAVDH 150
Cdd:PLN03212  105 GRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTH 137
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 36-139 7.19e-20

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 87.54  E-value: 7.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280997154  36 DKIKGPWSAEEDRVLTRLVERYGPRNWSLISRYVKGRSGKSCRLRWCNQLCPGVEHRPFSPAEDEAIIAAHSRYGNRWAT 115
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|....
gi 1280997154 116 IARLLPGRTDNAVKNHWNSTLKRR 139
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDL 120
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 93-136 1.85e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 67.91  E-value: 1.85e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1280997154  93 PFSPAEDEAIIAAHSRYGNRWATIARLLPGRTDNAVKNHWNSTL 136
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 42-100 3.49e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 67.34  E-value: 3.49e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1280997154  42 WSAEEDRVLTRLVERYGpRNWSLISRYVKGRSGKSCRLRWCNQLCPGVEHRPFSPAEDE 100
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 41-83 1.04e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.67  E-value: 1.04e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1280997154  41 PWSAEEDRVLTRLVERYGPRNWSLISRYVKGRSGKSCRLRWCN 83
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRN 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
39-83 1.09e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 65.71  E-value: 1.09e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1280997154   39 KGPWSAEEDRVLTRLVERYGPRNWSLISRYVKGRSGKSCRLRWCN 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRN 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 39-85 2.07e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.83  E-value: 2.07e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1280997154  39 KGPWSAEEDRVLTRLVERYGpRNWSLISRYVKGRSGKSCRLRWCNQL 85
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 93-136 4.71e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.74  E-value: 4.71e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1280997154  93 PFSPAEDEAIIAAHSRYG-NRWATIARLLPGRTDNAVKNHWNSTL 136
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
92-138 7.59e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.39  E-value: 7.59e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1280997154   92 RPFSPAEDEAIIAAHSRYG-NRWATIARLLPGRTDNAVKNHWNSTLKR 138
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 94-143 2.12e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 51.93  E-value: 2.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1280997154  94 FSPAEDEAIIAAHSRYGNRWATIARLLPGRTDNAVKNHWNSTLKRRVRDQ 143
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRG 50
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 41-83 3.13e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 37.55  E-value: 3.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1280997154  41 PWSAEEDRVLTRLVERYGPRNWSLI---SRYVKGRSGKSCRLRWCN 83
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKIlkdYFFVNNRTSVDLKDKWRN 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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