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Conserved domains on  [gi|1281051944|ref|XP_022968135|]
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reticulon-like protein B14 [Cucurbita maxima]

Protein Classification

reticulon family protein( domain architecture ID 10493657)

reticulon family protein associates with the endoplasmic reticulum (ER) through a C-terminal di-lysine ER retention motif; such as mammalian RTN4/Nogo, a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching

Gene Ontology:  GO:0005789|GO:0005783
PubMed:  12832288

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 20-172 2.61e-39

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


:

Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 131.84  E-value: 2.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  20 VAELMLWKKKRESAAMLAGISGVWFLLEVLDYHFVTLLCYLLIITMLLLFSWNKLALLINWAPPSVHDFEISNATLTHFF 99
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRPPPPIPELELSEETVRELA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1281051944 100 DTF----NWFLHHFFQISTAQNFKLFAMVMGSIWLVSLIGELMNSLNLIYIVFLSLQTVPIVLDKYEEEIHKLVSNL 172
Cdd:pfam02453  81 DSLrvliNFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDAYVEKA 157
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 20-172 2.61e-39

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 131.84  E-value: 2.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  20 VAELMLWKKKRESAAMLAGISGVWFLLEVLDYHFVTLLCYLLIITMLLLFSWNKLALLINWAPPSVHDFEISNATLTHFF 99
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRPPPPIPELELSEETVRELA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1281051944 100 DTF----NWFLHHFFQISTAQNFKLFAMVMGSIWLVSLIGELMNSLNLIYIVFLSLQTVPIVLDKYEEEIHKLVSNL 172
Cdd:pfam02453  81 DSLrvliNFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDAYVEKA 157
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 18-178 1.40e-03

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411697  Cd Length: 192  Bit Score: 38.05  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  18 GKVAELMLWKKKRESAAMLAGISGVWFLLEVLDYHFVTLLCYLLIITMLLLFSWNKLALLINWAPP---------SVHDF 88
Cdd:cd22558    14 MRAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPEpeedpeswtPIHPR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  89 EISNATLTHFFD----TFNWFLHHFFQISTAQNFKLFAMVMGSIWLVSLIGELMNSLNLIYIVFLSLQTVPI-----VLD 159
Cdd:cd22558    94 LLSVPELCRHLAeswvSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLSLLLWPLvvyhrVPQ 173

                         170
                  ....*....|....*....
gi 1281051944 160 KYEEEIHKLVSNLKSSMDT 178
Cdd:cd22558   174 KIYTKLEPVLMQLEYSMKI 192
 
Name Accession Description Interval E-value
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 20-172 2.61e-39

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 131.84  E-value: 2.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  20 VAELMLWKKKRESAAMLAGISGVWFLLEVLDYHFVTLLCYLLIITMLLLFSWNKLALLINWAPPSVHDFEISNATLTHFF 99
Cdd:pfam02453   1 VADLLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLFLWAEYAGKLNRPPPPIPELELSEETVRELA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1281051944 100 DTF----NWFLHHFFQISTAQNFKLFAMVMGSIWLVSLIGELMNSLNLIYIVFLSLQTVPIVLDKYEEEIHKLVSNL 172
Cdd:pfam02453  81 DSLrvliNFALSELRRIALGEDLKLFLKVAVVLWILSYVGSLFSFLTLLYIGVVLAFTVPLLYEKYEDEIDAYVEKA 157
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 18-178 1.40e-03

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411697  Cd Length: 192  Bit Score: 38.05  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  18 GKVAELMLWKKKRESAAMLAGISGVWFLLEVLDYHFVTLLCYLLIITMLLLFSWNKLALLINWAPP---------SVHDF 88
Cdd:cd22558    14 MRAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPEpeedpeswtPIHPR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1281051944  89 EISNATLTHFFD----TFNWFLHHFFQISTAQNFKLFAMVMGSIWLVSLIGELMNSLNLIYIVFLSLQTVPI-----VLD 159
Cdd:cd22558    94 LLSVPELCRHLAeswvSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLSLLLWPLvvyhrVPQ 173

                         170
                  ....*....|....*....
gi 1281051944 160 KYEEEIHKLVSNLKSSMDT 178
Cdd:cd22558   174 KIYTKLEPVLMQLEYSMKI 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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