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Conserved domains on  [gi|1279752690|ref|XP_022959122|]
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protein STRICTOSIDINE SYNTHASE-LIKE 6-like [Cucurbita moschata]

Protein Classification

strictosidine synthase family protein( domain architecture ID 11465301)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Str_synth super family cl22863
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 162-248 4.02e-36

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


The actual alignment was detected with superfamily member pfam03088:

Pssm-ID: 354965 [Multi-domain]  Cd Length: 89  Bit Score: 126.79  E-value: 4.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 162 DGVDVADD-GTVYFTDASSKYRLHNFIFDMLEGRPLGRLLRYDPTTKTTELLVGDLYFANGVAVAPSQDFVIFCETPLRR 240
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*...
gi 1279752690 241 CRKYYIAG 248
Cdd:pfam03088  81 ISRYWIKE 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 76-281 1.13e-29

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 115.37  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  76 PEDFAYDSDlGLVYTGD-SDGWLKRVRLNDSAVEKWAFTGGRPLGVALGPDGSVLVADADKGLLKVTKE-GVVETLTTEA 153
Cdd:COG3386    10 GEGPVWDPD-GRLYWVDiPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPAdGEVTVLADEY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 154 GGLKFQLTDGVdVADDGTVYFTdasskyrlhnfifDMLEGRPLGRLLRYDPtTKTTELLVGDLYFANGVAVAPSQDFVIF 233
Cdd:COG3386    89 GKPLNRPNDGV-VDPDGRLYFT-------------DMGEYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTLYV 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1279752690 234 CETPLRRCRKYYIAGDRK-GSIEKFVD--NLPGTPDNIKYDGHGHFWIGLP 281
Cdd:COG3386   154 ADTGAGRIYRFDLDADGTlGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
 
Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 162-248 4.02e-36

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 126.79  E-value: 4.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 162 DGVDVADD-GTVYFTDASSKYRLHNFIFDMLEGRPLGRLLRYDPTTKTTELLVGDLYFANGVAVAPSQDFVIFCETPLRR 240
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*...
gi 1279752690 241 CRKYYIAG 248
Cdd:pfam03088  81 ISRYWIKE 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 76-281 1.13e-29

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 115.37  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  76 PEDFAYDSDlGLVYTGD-SDGWLKRVRLNDSAVEKWAFTGGRPLGVALGPDGSVLVADADKGLLKVTKE-GVVETLTTEA 153
Cdd:COG3386    10 GEGPVWDPD-GRLYWVDiPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPAdGEVTVLADEY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 154 GGLKFQLTDGVdVADDGTVYFTdasskyrlhnfifDMLEGRPLGRLLRYDPtTKTTELLVGDLYFANGVAVAPSQDFVIF 233
Cdd:COG3386    89 GKPLNRPNDGV-VDPDGRLYFT-------------DMGEYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTLYV 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1279752690 234 CETPLRRCRKYYIAGDRK-GSIEKFVD--NLPGTPDNIKYDGHGHFWIGLP 281
Cdd:COG3386   154 ADTGAGRIYRFDLDADGTlGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 81-281 1.32e-11

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 64.21  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  81 YDSDLGLVYTGDSDG-WLKRVRLNDSAVEKWAFTGgrPLG-VALGPDGSVLVADADKGLLKVTKEGVVETLTTEAGGLKF 158
Cdd:pfam08450   7 WDEEEGALYWVDILGgRIHRLDPATGKETVWDTPG--PVGaIAPRDDGGLIVALKDGVALLDLATGELTPLADPEDDDWP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 159 QL--TDGVdVADDGTVYFTDASskyrlhnfiFDMLEGRPLGRLLRYDPTTKTTELLvGDLYFANGVAVAPSQDFVIFCET 236
Cdd:pfam08450  85 LNrfNDGK-VDPDGRFWFGTMG---------DDEAPGGDPGALYRLDPDGKLTRVL-DGLTISNGLAWSPDGRTLYFADS 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1279752690 237 PLRRCRKY--YIAGDRKGSIEKFVD--NLPGTPDNIKYDGHGHFWIGLP 281
Cdd:pfam08450 154 PARKIWAYdyDLDGGLISNRRVFADfkPGLGRPDGMAVDAEGNVWVARW 202
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 69-229 1.06e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  69 GVAELKAPEDFAYDSDlGLVYTgdSDGWLKRVRLNDSAVEKWAFTGGR---------PLGVALGPDGSVLVADADKG-LL 138
Cdd:cd05819     3 GPGELNNPQGIAVDSS-GNIYV--ADTGNNRIQVFDPDGNFITSFGSFgsgdgqfnePAGVAVDSDGNLYVADTGNHrIQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 139 KVTKEGVVETLTTEAGGLKFQLTD--GVDVADDGTVYFTDASSKyrlhnfifdmlegrplgRLLRYDPTTKTTELL---- 212
Cdd:cd05819    80 KFDPDGNFLASFGGSGDGDGEFNGprGIAVDSSGNIYVADTGNH-----------------RIQKFDPDGEFLTTFgsgg 142

                         170
                  ....*....|....*....
gi 1279752690 213 --VGDLYFANGVAVAPSQD 229
Cdd:cd05819   143 sgPGQFNGPTGVAVDSDGN 161
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
114-236 3.19e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.09  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 114 GGRPLGVALGPDGSVLVADADKGLLKV--TKEGVVETLTTEAGGlkfqLTDGVDVADDGTVYFTDASSkyrlhnfifdml 191
Cdd:COG4257    16 GSGPRDVAVDPDGAVWFTDQGGGRIGRldPATGEFTEYPLGGGS----GPHGIAVDPDGNLWFTDNGN------------ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1279752690 192 egrplGRLLRYDPTTKTTELLV--GDLYFANGVAVAPSQDfVIFCET 236
Cdd:COG4257    80 -----NRIGRIDPKTGEITTFAlpGGGSNPHGIAFDPDGN-LWFTDQ 120
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 79-175 1.01e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 43.80  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  79 FAYDSDLGLVYtgdsdgwlkRVRLnDSAVEKWA--FTGgrPLGVALGPDGSVLVA----------DADKGLLKVTKEGVV 146
Cdd:NF033206  224 FPFPPGRARVY---------RVDP-GGAPTVYAtgFTG--LTDLAFDPDGNLYVLelagggllkgDPTGSLIRIAPDGTR 291

                          90       100
                  ....*....|....*....|....*....
gi 1279752690 147 ETLtteAGGLkfQLTDGVDVADDGTVYFT 175
Cdd:NF033206  292 TTL---LDGL--ELPTGLAVGPDGTLYVT 315
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 117-216 1.55e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 43.42  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 117 PLGVALGPDGSVLVADADKG---------------LLKVTKEGVVETLTTEAGGLKF--QLTDGVDVA--DDGTVYFT-- 175
Cdd:NF033206   10 PRGLAFGPDGRLYVAEAGTGgcpspsplcygntgaVSRITPDGKKTRVVTGLPSLALgeGAAGPADVAfdGDGTYYVLtg 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1279752690 176 -DASSKYRlhnfifdmLEGRPLGRLLRYDPTTKTTeLLVGDL 216
Cdd:NF033206   90 lGGDPATR--------DGGPLLGTLLKVDLGTGSL-TTLADL 122
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 116-232 2.77e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 42.52  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 116 RPLGVALGPDGSVLVADADKGLL-KVTKEGVVETL--------TTEAGGLKFQLTD--GVDVADDGTVYFTDASSkyrlh 184
Cdd:cd14953   188 NPTGVAVDAAGNLYVADRGNHRIrKITPDGVVTTVagtgtagfSGDGGATAAQLNNptGVAVDAAGNLYVADSGN----- 262

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1279752690 185 nfifdmlegrplGRLLRYDPTTKTTELLVGD--------------LYFANGVAVAPSQDFVI 232
Cdd:cd14953   263 ------------HRIRKITPAGVVTTVAGGGagfsgdggpatsaqFNNPTGVAVDAAGNLYV 312
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 117-230 4.12e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 41.88  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 117 PLGVALGPDGSVLVAD-----ADKGLLKVTKegVVET--LTTEAGGLKfQLTDgVDVADDGTVYFtdasskyrLHNFIFD 189
Cdd:NF033206  205 PTGVAVGPDGALYVSEltgfpFPPGRARVYR--VDPGgaPTVYATGFT-GLTD-LAFDPDGNLYV--------LELAGGG 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279752690 190 MLEGRPLGRLLRYDPTTKTTELLVGdLYFANGVAVAPSQDF 230
Cdd:NF033206  273 LLKGDPTGSLIRIAPDGTRTTLLDG-LELPTGLAVGPDGTL 312
 
Name Accession Description Interval E-value
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 162-248 4.02e-36

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 126.79  E-value: 4.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 162 DGVDVADD-GTVYFTDASSKYRLHNFIFDMLEGRPLGRLLRYDPTTKTTELLVGDLYFANGVAVAPSQDFVIFCETPLRR 240
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*...
gi 1279752690 241 CRKYYIAG 248
Cdd:pfam03088  81 ISRYWIKE 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 76-281 1.13e-29

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 115.37  E-value: 1.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  76 PEDFAYDSDlGLVYTGD-SDGWLKRVRLNDSAVEKWAFTGGRPLGVALGPDGSVLVADADKGLLKVTKE-GVVETLTTEA 153
Cdd:COG3386    10 GEGPVWDPD-GRLYWVDiPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPAdGEVTVLADEY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 154 GGLKFQLTDGVdVADDGTVYFTdasskyrlhnfifDMLEGRPLGRLLRYDPtTKTTELLVGDLYFANGVAVAPSQDFVIF 233
Cdd:COG3386    89 GKPLNRPNDGV-VDPDGRLYFT-------------DMGEYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTLYV 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1279752690 234 CETPLRRCRKYYIAGDRK-GSIEKFVD--NLPGTPDNIKYDGHGHFWIGLP 281
Cdd:COG3386   154 ADTGAGRIYRFDLDADGTlGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 81-281 1.32e-11

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 64.21  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  81 YDSDLGLVYTGDSDG-WLKRVRLNDSAVEKWAFTGgrPLG-VALGPDGSVLVADADKGLLKVTKEGVVETLTTEAGGLKF 158
Cdd:pfam08450   7 WDEEEGALYWVDILGgRIHRLDPATGKETVWDTPG--PVGaIAPRDDGGLIVALKDGVALLDLATGELTPLADPEDDDWP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 159 QL--TDGVdVADDGTVYFTDASskyrlhnfiFDMLEGRPLGRLLRYDPTTKTTELLvGDLYFANGVAVAPSQDFVIFCET 236
Cdd:pfam08450  85 LNrfNDGK-VDPDGRFWFGTMG---------DDEAPGGDPGALYRLDPDGKLTRVL-DGLTISNGLAWSPDGRTLYFADS 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1279752690 237 PLRRCRKY--YIAGDRKGSIEKFVD--NLPGTPDNIKYDGHGHFWIGLP 281
Cdd:pfam08450 154 PARKIWAYdyDLDGGLISNRRVFADfkPGLGRPDGMAVDAEGNVWVARW 202
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 69-229 1.06e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  69 GVAELKAPEDFAYDSDlGLVYTgdSDGWLKRVRLNDSAVEKWAFTGGR---------PLGVALGPDGSVLVADADKG-LL 138
Cdd:cd05819     3 GPGELNNPQGIAVDSS-GNIYV--ADTGNNRIQVFDPDGNFITSFGSFgsgdgqfnePAGVAVDSDGNLYVADTGNHrIQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 139 KVTKEGVVETLTTEAGGLKFQLTD--GVDVADDGTVYFTDASSKyrlhnfifdmlegrplgRLLRYDPTTKTTELL---- 212
Cdd:cd05819    80 KFDPDGNFLASFGGSGDGDGEFNGprGIAVDSSGNIYVADTGNH-----------------RIQKFDPDGEFLTTFgsgg 142

                         170
                  ....*....|....*....
gi 1279752690 213 --VGDLYFANGVAVAPSQD 229
Cdd:cd05819   143 sgPGQFNGPTGVAVDSDGN 161
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
71-227 1.17e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 52.71  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  71 AELKAPEDFAYDSDLGLVYTGDSDGWLKRVRLNDSAVEKWAFTGG-RPLGVALGPDGSVLVAD-ADKGLLKVT-KEGVVE 147
Cdd:COG4257    14 APGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGsGPHGIAVDPDGNLWFTDnGNNRIGRIDpKTGEIT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 148 TLTTEAGGLKFQltdGVDVADDGTVYFTDASSkyrlhnfifdmlegrplGRLLRYDPTTKTTEL--LVGDLYFANGVAVA 225
Cdd:COG4257    94 TFALPGGGSNPH---GIAFDPDGNLWFTDQGG-----------------NRIGRLDPATGEVTEfpLPTGGAGPYGIAVD 153


                  ..
gi 1279752690 226 PS 227
Cdd:COG4257   154 PD 155
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
71-236 5.41e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.40  E-value: 5.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  71 AELKAPEDFAYDSDLGLVYTGDSDGWLKRVRLNDSAVEKWAF--TGGRPLGVALGPDGSVLVADADKG-LLKVTKEGvvE 147
Cdd:COG4257    99 GGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPLptGGAGPYGIAVDPDGNLWVTDFGANaIGRIDPDT--G 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 148 TLTTEAGGLKFQLTDGVDVADDGTVYFTDASSkyrlhnfifdmlegrplGRLLRYDPTTKT-TEL-LVGDLYFANGVAVA 225
Cdd:COG4257   177 TLTEYALPTPGAGPRGLAVDPDGNLWVADTGS-----------------GRIGRFDPKTGTvTEYpLPGGGARPYGVAVD 239

                         170
                  ....*....|.
gi 1279752690 226 PsQDFVIFCET 236
Cdd:COG4257   240 G-DGRVWFAES 249
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
76-210 1.20e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 49.63  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  76 PEDFAYDSDLGLVYTGDSDGWLKRVRLNDSAVEKWAF--TGGRPLGVALGPDGSVLVADADKG-LLKV-TKEGVVETLTT 151
Cdd:COG4257   147 PYGIAVDPDGNLWVTDFGANAIGRIDPDTGTLTEYALptPGAGPRGLAVDPDGNLWVADTGSGrIGRFdPKTGTVTEYPL 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1279752690 152 EAGGlkfQLTDGVDVADDGTVYFTDASSkyrlhnfifdmlegrplGRLLRYDPTTKTTE 210
Cdd:COG4257   227 PGGG---ARPYGVAVDGDGRVWFAESGA-----------------NRIVRFDPDTELTE 265
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 69-176 1.82e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 48.82  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  69 GVAELKAPEDFAYDSDlGLVYTGDSDGWlkRVRLNDSA---VEKWAFTGGR------PLGVALGPDGSVLVADADKGLLK 139
Cdd:cd14956   149 EPGSFNYPRGVAVDPD-GTLYVADTYND--RIQVFDNDgafLRKWGGRGTGpgqfnyPYGIAIDPDGNVFVADFGNNRIQ 225

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1279752690 140 V-TKEGVVETLTTEAGGLKFQLTD--GVDVADDGTVYFTD 176
Cdd:cd14956   226 KfTADGTFLTSWGSPGTGPGQFKNpwGVVVDADGTVYVAD 265
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
114-236 3.19e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.09  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 114 GGRPLGVALGPDGSVLVADADKGLLKV--TKEGVVETLTTEAGGlkfqLTDGVDVADDGTVYFTDASSkyrlhnfifdml 191
Cdd:COG4257    16 GSGPRDVAVDPDGAVWFTDQGGGRIGRldPATGEFTEYPLGGGS----GPHGIAVDPDGNLWFTDNGN------------ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1279752690 192 egrplGRLLRYDPTTKTTELLV--GDLYFANGVAVAPSQDfVIFCET 236
Cdd:COG4257    80 -----NRIGRIDPKTGEITTFAlpGGGSNPHGIAFDPDGN-LWFTDQ 120
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 72-186 4.88e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 47.65  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  72 ELKAPEDFAYDSDlGLVYTGDSDGwlKRVR-LNDSAVEKWAFTGG--------RPLGVALGPDGSVLVADADKGLLKV-T 141
Cdd:cd14957    63 QFNSPYGIAVDSN-GNIYVADTDN--NRIQvFNSSGVYQYSIGTGgsgdgqfnGPYGIAVDSNGNIYVADTGNHRIQVfT 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1279752690 142 KEGVVE-TLTTEAGGL-KFQLTDGVDVADDGTVYFTDASSkYRLHNF 186
Cdd:cd14957   140 SSGTFSySIGSGGTGPgQFNGPQGIAVDSDGNIYVADTGN-HRIQVF 185
SSL_N pfam20067
Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of ...
 62-100 8.08e-06

Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of strictosidine synthase-like (SSL) proteins including Adipocyte plasma membrane- associated proteins (APMAPs) from animals, Protein STRICTOSIDINE SYNTHASE-LIKE (SSLs) from Arabidopsis and SGL proteins, being also present in bacterial sequences. It is about 50 amino acids in length. It contains residues involved in metal coordination in the active site. This domain is also found in Gluconolactonase and Sugar lactone lactonase. These proteins share a six-bladed beta-propeller fold structure and have similar structural and mechanistic features to SS (strictosidine synthase) that involve nucleophilic attack on an electrophilic substrate, although they do not catalyze the SS reaction as they lack the catalytic glutamate required for SS activity; they catalyze hydrolytic reactions instead. APMAPs shows similarity with paraoxonases (PON) and has a strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. They are involved in adipocyte differentiation.


Pssm-ID: 437899 [Multi-domain]  Cd Length: 46  Bit Score: 42.48  E-value: 8.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1279752690  62 LQGAERVGVAELKAPEDFAYDSDlGLVYTGDSDGWLKRV 100
Cdd:pfam20067   9 LAGAELIALGGEHGPEDIAVDPD-GRLYTGLHDGRIVRM 46
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 71-224 8.55e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.82  E-value: 8.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  71 AELKAPEDFAYDSDlGLVYTGDS--DGWLKRVRLNDSAVEkWAFTG-GRPLGVALGPDGSVLVADADKGllKVTKEGVVE 147
Cdd:cd14952    49 TGLYQPQGVAVDAA-GTVYVTDFgnNRVLKLAAGSTTQTV-LPFTGlNDPTGVAVDAAGNVYVADTGNN--RVLKLAAGS 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 148 TLTTEaggLKFQ-LTDGVDVADD--GTVYFTDasskyRLHNfifdmlegrplgRLLRYDPTTKT-TELLVGDLYFANGVA 223
Cdd:cd14952   125 NTQTV---LPFTgLSNPDGVAVDgaGNVYVTD-----TGNN------------RVLKLAAGSTTqTVLPFTGLNSPSGVA 184


                  .
gi 1279752690 224 V 224
Cdd:cd14952   185 V 185
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 64-178 1.00e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.54  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  64 GAERVGVAELKAPEDFAYDSDlGLVYTgdSDGWLKRVR---LNDSAVEKWAFTG------GRPLGVALGPDGSVLVADAD 134
Cdd:cd05819   139 GSGGSGPGQFNGPTGVAVDSD-GNIYV--ADTGNHRIQvfdPDGNFLTTFGSTGtgpgqfNYPTGIAVDSDGNIYVADSG 215

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1279752690 135 KG-LLKVTKEGVVETLTTEAGGLKFQLTD--GVDVADDGTVYFTDAS 178
Cdd:cd05819   216 NNrVQVFDPDGAGFGGNGNFLGSDGQFNRpsGLAVDSDGNLYVADTG 262
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 91-176 1.04e-05

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 46.80  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  91 GDSDGWLKRVRLNDsavekwaftggrPLGVALGPDGSVLVADADKGLLKVT--KEGVVETLtteAGGLKFQLTD------ 162
Cdd:cd14951   184 GDRDGPGAEALLQH------------PLGVAALPDGSVYVADTYNHKIKRVdpATGEVSTL---AGTGKAGYKDleaqfs 248

                          90
                  ....*....|....*..
gi 1279752690 163 ---GVDVADDGTVYFTD 176
Cdd:cd14951   249 epsGLVVDGDGRLYVAD 265
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 69-227 1.87e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.77  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  69 GVAELKAPEDFAYDSDlGLVYTGDSDG-WLKRVRLNDSAVEKWAFTGG------RPLGVALGPDGSVLVADADKG-LLKV 140
Cdd:cd05819    97 GDGEFNGPRGIAVDSS-GNIYVADTGNhRIQKFDPDGEFLTTFGSGGSgpgqfnGPTGVAVDSDGNIYVADTGNHrIQVF 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 141 TKEGVVETL--TTEAGGLKFQLTDGVDVADDGTVYFTDaSSKYRLHNFIFDMLEGRPLGRLLRYDpttkttellvGDLYF 218
Cdd:cd05819   176 DPDGNFLTTfgSTGTGPGQFNYPTGIAVDSDGNIYVAD-SGNNRVQVFDPDGAGFGGNGNFLGSD----------GQFNR 244


                  ....*....
gi 1279752690 219 ANGVAVAPS 227
Cdd:cd05819   245 PSGLAVDSD 253
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 79-175 1.01e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 43.80  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  79 FAYDSDLGLVYtgdsdgwlkRVRLnDSAVEKWA--FTGgrPLGVALGPDGSVLVA----------DADKGLLKVTKEGVV 146
Cdd:NF033206  224 FPFPPGRARVY---------RVDP-GGAPTVYAtgFTG--LTDLAFDPDGNLYVLelagggllkgDPTGSLIRIAPDGTR 291

                          90       100
                  ....*....|....*....|....*....
gi 1279752690 147 ETLtteAGGLkfQLTDGVDVADDGTVYFT 175
Cdd:NF033206  292 TTL---LDGL--ELPTGLAVGPDGTLYVT 315
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 117-216 1.55e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 43.42  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 117 PLGVALGPDGSVLVADADKG---------------LLKVTKEGVVETLTTEAGGLKF--QLTDGVDVA--DDGTVYFT-- 175
Cdd:NF033206   10 PRGLAFGPDGRLYVAEAGTGgcpspsplcygntgaVSRITPDGKKTRVVTGLPSLALgeGAAGPADVAfdGDGTYYVLtg 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1279752690 176 -DASSKYRlhnfifdmLEGRPLGRLLRYDPTTKTTeLLVGDL 216
Cdd:NF033206   90 lGGDPATR--------DGGPLLGTLLKVDLGTGSL-TTLADL 122
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
86-141 1.66e-04

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 43.38  E-value: 1.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1279752690  86 GLVYTGD---------------SDGWLKRVRLND----SAVEKWAF-TGGRPLGVALGPDGSVLVADADKG-LLKVT 141
Cdd:COG2133   288 LAFYTGDafpaeyrgglfvadlGSRRVVRVPLDGdgkvVGEEDFLTgAGGRPRDVAQGPDGALYVLDDNDGrIYRIT 364
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
64-221 1.84e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  64 GAERVGVAELKAPEDFAYDSDLGLVYTGDS-DGWLKRVRLNDSAVEKWAFTGGRPLGVALGPDGS-VLVADADKGLLKV- 140
Cdd:COG3391    58 AGLGLGAAAVADADGADAGADGRRLYVANSgSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGrLYVADSGNGRVSVi 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 141 -TKEG-VVETLTTEAGglkfqlTDGVDVADDG-TVYFTDASSKyRLHNFI--FDMLEGRPLGRL--------LRYDPTTK 207
Cdd:COG3391   138 dTATGkVVATIPVGAG------PHGIAVDPDGkRLYVANSGSN-TVSVIVsvIDTATGKVVATIpvgggpvgVAVSPDGR 210

                         170
                  ....*....|....
gi 1279752690 208 TtellvgdLYFANG 221
Cdd:COG3391   211 R-------LYVANR 217
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 116-232 2.77e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 42.52  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 116 RPLGVALGPDGSVLVADADKGLL-KVTKEGVVETL--------TTEAGGLKFQLTD--GVDVADDGTVYFTDASSkyrlh 184
Cdd:cd14953   188 NPTGVAVDAAGNLYVADRGNHRIrKITPDGVVTTVagtgtagfSGDGGATAAQLNNptGVAVDAAGNLYVADSGN----- 262

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1279752690 185 nfifdmlegrplGRLLRYDPTTKTTELLVGD--------------LYFANGVAVAPSQDFVI 232
Cdd:cd14953   263 ------------HRIRKITPAGVVTTVAGGGagfsgdggpatsaqFNNPTGVAVDAAGNLYV 312
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 117-230 4.12e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 41.88  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 117 PLGVALGPDGSVLVAD-----ADKGLLKVTKegVVET--LTTEAGGLKfQLTDgVDVADDGTVYFtdasskyrLHNFIFD 189
Cdd:NF033206  205 PTGVAVGPDGALYVSEltgfpFPPGRARVYR--VDPGgaPTVYATGFT-GLTD-LAFDPDGNLYV--------LELAGGG 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279752690 190 MLEGRPLGRLLRYDPTTKTTELLVGdLYFANGVAVAPSQDF 230
Cdd:NF033206  273 LLKGDPTGSLIRIAPDGTRTTLLDG-LELPTGLAVGPDGTL 312
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 115-184 6.27e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 41.36  E-value: 6.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 115 GRPLGVALGPDGSVLVADADKG-LLKVTKEGVVETLTTEAGGL----------KFQLTDGVDVADDGTVYFTDASSkYRL 183
Cdd:cd14953   242 NNPTGVAVDAAGNLYVADSGNHrIRKITPAGVVTTVAGGGAGFsgdggpatsaQFNNPTGVAVDAAGNLYVADTGN-NRI 320


                  .
gi 1279752690 184 H 184
Cdd:cd14953   321 R 321
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 65-176 9.36e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.27  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  65 AERVGVAELKAPEDFAYDSDlGLVYTGDSDGwlKRVRlndsaveKWA----------FTGGR-PLGVALGPDGSVLVADA 133
Cdd:cd14952   127 QTVLPFTGLSNPDGVAVDGA-GNVYVTDTGN--NRVL-------KLAagsttqtvlpFTGLNsPSGVAVDTAGNVYVTDH 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1279752690 134 DKGllKVTK--EGVVETLTTEAGGLKFqlTDGVDVADDGTVYFTD 176
Cdd:cd14952   197 GNN--RVLKlaAGSTTPTVLPFTGLNG--PLGVAVDAAGNVYVAD 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
74-136 1.12e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 1.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1279752690  74 KAPEDFAYDSDLGLVYTGDSDG-----WLKRVRLNDSAVEKWAFTGGRPLGVALGPDGS-VLVADADKG 136
Cdd:COG3391   152 AGPHGIAVDPDGKRLYVANSGSntvsvIVSVIDTATGKVVATIPVGGGPVGVAVSPDGRrLYVANRGSN 220
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 111-232 1.65e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.50  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 111 AFTGGR-PLGVALGPDGSVLVADADKGLlkvtkegVVEtLTTEAGG---LKFQLTD---GVDVADDGTVYFTDASSkyrl 183
Cdd:cd14952     5 PFTGLDgPGGVAVDAAGNVYVADSGNNR-------VLK-LAAGSTTqtvLPFTGLYqpqGVAVDAAGTVYVTDFGN---- 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1279752690 184 hnfifdmlegrplGRLLRYDP-TTKTTELLVGDLYFANGVAVAPSQDFVI 232
Cdd:cd14952    73 -------------NRVLKLAAgSTTQTVLPFTGLNDPTGVAVDAAGNVYV 109
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 73-226 1.74e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  73 LKAPEDFAYDSdlGLVYTGDSDGWlkRVRLNDsavEKWAFT---GGR---------PLGVALGPDGSVLVADADKGLLKV 140
Cdd:cd14963     9 LNKPMGVAVSD--GRIYVADTNNH--RVQVFD---YEGKFKksfGGPgtgpgefkyPYGIAVDSDGNIYVADLYNGRIQV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 141 -TKEG-VVETLTTEAGGLKFQLTDGVDVaDDGTVYFTDAsSKYRLhnFIFDmlegrPLGRLLRYDPTTKTTEllvGDLYF 218
Cdd:cd14963    82 fDPDGkFLKYFPEKKDRVKLISPAGLAI-DDGKLYVSDV-KKHKV--IVFD-----LEGKLLLEFGKPGSEP---GELSY 149


                  ....*...
gi 1279752690 219 ANGVAVAP 226
Cdd:cd14963   150 PNGIAVDE 157
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 76-176 2.25e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 39.56  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  76 PEDFAYDSDlGLVYTGDSDGwlKRVR-LNDSAVEKWAFTGG--------RPLGVALGPDGSVLVADADKGLLKV-TKEGV 145
Cdd:cd14957   114 PYGIAVDSN-GNIYVADTGN--HRIQvFTSSGTFSYSIGSGgtgpgqfnGPQGIAVDSDGNIYVADTGNHRIQVfTSSGT 190

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279752690 146 VETLTTEAGGLKFQLTD--GVDVADDGTVYFTD 176
Cdd:cd14957   191 FQYTFGSSGSGPGQFSDpyGIAVDSDGNIYVAD 223
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 117-245 2.66e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.18  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690 117 PLGVALGPDGSVLVADADKGLLKV-TKEGVVETLTTEAgglkFQLTDGVDVADDGTVYFTDASSKYrLHNFIFDmlegRP 195
Cdd:cd14961    60 PLDVAVTPDGHIVVTDAGDRSVKVfSFDGRLKLFVRKS----FSLPWGVAVNPSGEILVTDSEAGK-LFVLTVD----FK 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1279752690 196 LGRLlrydpttKTTELLVGDLYFANGVAVAPSQDfVIFCETPLRRCRKYY 245
Cdd:cd14961   131 LGIL-------KKGQKLCSQLCRPRFVAVSRLGA-VAVTEHLFANGTRSS 172
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 71-176 2.66e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 39.44  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  71 AELKAPEDFAYDSDlGLVYTGDSDGwlKRVR--LNDSAVEKWAFTGGR--------------PLGVALGPDGSVLVADAD 134
Cdd:cd14953    20 ARFNSPSGVAVDAA-GNLYVADRGN--HRIRkiTPDGVVTTVAGTGTAgfadgggaaaqfntPSGVAVDAAGNLYVADTG 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1279752690 135 KGLL-KVTKEGVVETL--TTEAGGL--------KFQLTDGVDVADDGTVYFTD 176
Cdd:cd14953    97 NHRIrKITPDGVVSTLagTGTAGFSddggataaQFNYPTGVAVDAAGNLYVAD 149
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 69-186 7.36e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 37.94  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279752690  69 GVAELKAPEDFAYDSDlGLVYTGDSDGwlKRVRLNDSA---VEKWAFTGG------RPLGVALGPDGSVLVADAD-KGLL 138
Cdd:cd14955   152 GDGQFNSPTGIAVDSA-GNVYVADTGN--NRIQKFTSTgtfLTKWGSEGSgdgqfnAPYGIAVDSAGNVYVADTGnNRIQ 228

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1279752690 139 KVTKEGvveTLTTEAGGL-----KFQLTDGVDVADDGTVYFTDaSSKYRLHNF 186
Cdd:cd14955   229 KFDSSG---TFITKWGSEgsgdgQFNSPSGIAVDSAGNVYVAD-SGNNRIQKF 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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