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Conserved domains on  [gi|1279760864|ref|XP_022929756|]
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two-component response regulator-like APRR1 isoform X2 [Cucurbita moschata]

Protein Classification

REC and CCT domain-containing protein( domain architecture ID 10361418)

REC and CCT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
REC super family cl19078
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 35-138 2.15e-57

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


The actual alignment was detected with superfamily member cd17582:

Pssm-ID: 473134 [Multi-domain]  Cd Length: 104  Bit Score: 186.45  E-value: 2.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMM 114
Cdd:cd17582     1 VLLVENDDSTRQIVTALLRKCSYEVTAASDGLQAWDVLEDEQNEIDLILTEVDLPVSSGFKLLSYIMRHKICKNIPVIMM 80

                          90       100
                  ....*....|....*....|....
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17582    81 SSQDSVGVVFKCLSKGAADYLVKP 104
CCT pfam06203
CCT motif; This short motif is found in a number of plant proteins. It is rich in basic amino ...
 466-509 5.09e-23

CCT motif; This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1. The CCT motif is about 45 amino acids long and contains a putative nuclear localization signal within the second half of the CCT motif. Toc1 mutants have been identified in this region.


:

Pssm-ID: 461849  Cd Length: 44  Bit Score: 91.79  E-value: 5.09e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1279760864 466 REAALIKFRQKRKERCFDKKIRYENRKQLAEKRPRVRGQFVRNG 509
Cdd:pfam06203   1 REEALLRYREKRKTRKFDKKIRYESRKALADKRPRVKGRFVKAD 44
 
Name Accession Description Interval E-value
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 35-138 2.15e-57

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 186.45  E-value: 2.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMM 114
Cdd:cd17582     1 VLLVENDDSTRQIVTALLRKCSYEVTAASDGLQAWDVLEDEQNEIDLILTEVDLPVSSGFKLLSYIMRHKICKNIPVIMM 80

                          90       100
                  ....*....|....*....|....
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17582    81 SSQDSVGVVFKCLSKGAADYLVKP 104
CCT pfam06203
CCT motif; This short motif is found in a number of plant proteins. It is rich in basic amino ...
 466-509 5.09e-23

CCT motif; This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1. The CCT motif is about 45 amino acids long and contains a putative nuclear localization signal within the second half of the CCT motif. Toc1 mutants have been identified in this region.


Pssm-ID: 461849  Cd Length: 44  Bit Score: 91.79  E-value: 5.09e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1279760864 466 REAALIKFRQKRKERCFDKKIRYENRKQLAEKRPRVRGQFVRNG 509
Cdd:pfam06203   1 REEALLRYREKRKTRKFDKKIRYESRKALADKRPRVKGRFVKAD 44
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 32-145 2.02e-21

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 91.51  E-value: 2.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  32 KVKILLCDnDSKSSQEVFTLLLR-CSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIP 110
Cdd:COG3706     1 PARILVVD-DDPTNRKLLRRLLEaAGYEVVEAADGEEALELLQEHRPDL--ILLDLEMPDMDGLELCRRLRADPRTADIP 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:COG3706    78 IIFLTALDDEEDRARALEAGADDYLTKPFDPEELL 112
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 35-145 4.57e-15

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.41  E-value: 4.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLRCS-YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyvtrdkELRR----I 109
Cdd:pfam00072   1 VLIVD-DDPLIRELLRQLLEKEgYVVAEADDGKEALELLKEERPDL--ILLDINMPGMDGLELLK------RIRRrdptT 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 110 PVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:pfam00072  72 PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELL 107
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
34-162 3.62e-11

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 63.20  E-value: 3.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIM 113
Cdd:PRK10161    4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDL--ILLDWMLPGGSGIQFIKHLKRESMTRDIPVVM 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRMLGLTE 162
Cdd:PRK10161   82 LTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEE 130
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 34-89 5.07e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 38.32  E-value: 5.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1279760864   34 KILLCDnDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEGPdiDIILTEVDLP 89
Cdd:smart00448   2 RILVVD-DDPLLRELLKALLeKEGYEVDEATDGEEALELLKEEKP--DLILLDIMMP 55
 
Name Accession Description Interval E-value
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 35-138 2.15e-57

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 186.45  E-value: 2.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMM 114
Cdd:cd17582     1 VLLVENDDSTRQIVTALLRKCSYEVTAASDGLQAWDVLEDEQNEIDLILTEVDLPVSSGFKLLSYIMRHKICKNIPVIMM 80

                          90       100
                  ....*....|....*....|....
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17582    81 SSQDSVGVVFKCLSKGAADYLVKP 104
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 35-152 6.73e-27

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 105.02  E-value: 6.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIILTEVDLPMAKGMKMLKYVTrdkELRRIPVIMM 114
Cdd:cd17584     1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKDEFDLVITDVHMPDMDGFEFLELIR---LEMDLPVIMM 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIW 152
Cdd:cd17584    78 SADGSTSTVMKGLAHGACDYLLKPVSIEDLKNIWQHVV 115
CCT pfam06203
CCT motif; This short motif is found in a number of plant proteins. It is rich in basic amino ...
 466-509 5.09e-23

CCT motif; This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1. The CCT motif is about 45 amino acids long and contains a putative nuclear localization signal within the second half of the CCT motif. Toc1 mutants have been identified in this region.


Pssm-ID: 461849  Cd Length: 44  Bit Score: 91.79  E-value: 5.09e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1279760864 466 REAALIKFRQKRKERCFDKKIRYENRKQLAEKRPRVRGQFVRNG 509
Cdd:pfam06203   1 REEALLRYREKRKTRKFDKKIRYESRKALADKRPRVKGRFVKAD 44
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 32-145 2.02e-21

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 91.51  E-value: 2.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  32 KVKILLCDnDSKSSQEVFTLLLR-CSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIP 110
Cdd:COG3706     1 PARILVVD-DDPTNRKLLRRLLEaAGYEVVEAADGEEALELLQEHRPDL--ILLDLEMPDMDGLELCRRLRADPRTADIP 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:COG3706    78 IIFLTALDDEEDRARALEAGADDYLTKPFDPEELL 112
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 28-147 1.26e-20

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 87.60  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  28 VDRSKVKILLCDnDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKEL 106
Cdd:COG0784     1 PPLGGKRILVVD-DNPDNRELLRRLLeRLGYEVTTAEDGAEALELLRAGPPDL--ILLDINMPGMDGLELLRRIRALPRL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279760864 107 RRIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:COG0784    78 PDIPIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEA 118
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 32-176 1.82e-20

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 89.63  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  32 KVKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKelRRIPV 111
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDL--ILLDLMLPGMDGLEVCRRLRARP--SDIPI 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRMLGLTEKQILNFDFDLATSD 176
Cdd:COG0745    77 IMLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLRVGDLLDLAAREVTRD 141
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 31-157 5.66e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 89.25  E-value: 5.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  31 SKVKILLCDnDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKelRRI 109
Cdd:COG2204     1 SMARILVVD-DDPDIRRLLKELLeRAGYEVETAASGEEALALLREEPPDL--VLLDLRMPGMDGLELLRELRALD--PDL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1279760864 110 PVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRM 157
Cdd:COG2204    76 PVILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRL 123
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 29-160 6.75e-19

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 85.60  E-value: 6.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  29 DRSKVKILLCDnDSKSSQEVFTLLLR-CSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELR 107
Cdd:COG3437     3 TGQAPTVLIVD-DDPENLELLRQLLRtLGYDVVTAESGEEALELLLEAPPDL--ILLDVRMPGMDGFELLRLLRADPSTR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1279760864 108 RIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLN-LWTHIWRRRRMLGL 160
Cdd:COG3437    80 DIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLArVRNALELRRLQREL 133
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 36-138 4.30e-18

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 79.58  E-value: 4.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  36 LLCDnDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKelRRIPVIMM 114
Cdd:cd00156     1 LIVD-DDPAIRELLKSLLeREGYEVDTAADGEEALELLREERPDL--VLLDLMMPGMDGLELLRKLRELP--PDIPVIVL 75

                          90       100
                  ....*....|....*....|....
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd00156    76 TAKADEEDAVRALELGADDYLVKP 99
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 31-166 2.87e-17

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 78.47  E-value: 2.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  31 SKVKILLCDNDSKSSQEVFTLLLRCS-YQVI-SVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKYVTRDKelRR 108
Cdd:COG4565     2 KMIRVLIVEDDPMVAELLRRYLERLPgFEVVgVASSGEEALALLAEH--RPDLILLDIYLPDGDGLELLRELRARG--PD 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1279760864 109 IPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRMLGLTEKQIL 166
Cdd:COG4565    78 VDVIVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQEEDL 135
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 34-145 1.42e-15

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 73.05  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIM 113
Cdd:cd17618     2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDL--ILLDWMLPGGSGIQFIRRLKRDEMTRDIPIIM 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17618    80 LTARGEEEDKVRGLEAGADDYITKPFSPRELV 111
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 36-138 3.45e-15

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 71.28  E-value: 3.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  36 LLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdIILtevDLPMAK--GMKMLKYVtRdKELRRIPVIM 113
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDL-IIL---DVMLPGmdGFEVCRRL-R-EKGSDIPIIM 74

                          90       100
                  ....*....|....*....|....*
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17574    75 LTAKDEEEDKVLGLELGADDYITKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 35-145 4.57e-15

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 71.41  E-value: 4.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLRCS-YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyvtrdkELRR----I 109
Cdd:pfam00072   1 VLIVD-DDPLIRELLRQLLEKEgYVVAEADDGKEALELLKEERPDL--ILLDINMPGMDGLELLK------RIRRrdptT 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 110 PVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:pfam00072  72 PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELL 107
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 35-140 4.19e-14

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 68.93  E-value: 4.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLRCS-YQVISVRSARQVI---------NALNAEGPDIDIILTEVDLPMAKGMKMLKYVTRDK 104
Cdd:cd17581     1 VLAVD-DSLVDRKVIERLLRISsCRVTAVDSGKRALeflgledeeDSSNFNEPKVNMIITDYCMPGMTGYDLLKKVKESS 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 105 ELRRIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLR 140
Cdd:cd17581    80 ALKEIPVVIMSSENIPTRISRCLEEGAEDFLLKPVK 115
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 33-139 5.55e-14

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 68.38  E-value: 5.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILteVDLPMAK--GMKMLKYVTrdKELRRIP 110
Cdd:cd17555     1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDL--VL--CDLRMPEmdGLEVLKQIT--KESPDTP 74

                          90       100
                  ....*....|....*....|....*....
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPL 139
Cdd:cd17555    75 VIVVSGAGVMSDAVEALRLGAWDYLTKPI 103
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 33-144 1.34e-13

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 67.54  E-value: 1.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDnDSKSSQEVFT-LLLRCSYQVISVRSARQVINALNAEgPDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPV 111
Cdd:cd17544     1 IKVLVVD-DSATSRNHLRaLLRRHNFQVLEAANGQEALEVLEQH-PDIKLVITDYNMPEMDGFELVREIRKKYSRDQLAI 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNEL 144
Cdd:cd17544    79 IGISASGDNALSARFIKAGANDFLTKPFLPEEF 111
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 34-138 5.76e-13

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 64.79  E-value: 5.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEVFTLLLR--CSYQVISV-RSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVtrdKELR-RI 109
Cdd:COG4753     1 KVLIVD-DEPLIREGLKRILEweAGFEVVGEaENGEEALELLEEHKPDL--VITDINMPGMDGLELLEAI---RELDpDT 74

                          90       100
                  ....*....|....*....|....*....
gi 1279760864 110 PVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:COG4753    75 KIIILSGYSDFEYAQEAIKLGADDYLLKP 103
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 35-138 1.19e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 64.07  E-value: 1.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLR-CSYQVISVRSARQVINALNAEGPDIdiILTEVDLPmakGM------KMLKyvtRDKELR 107
Cdd:cd19920     1 ILIVD-DVPDNLRLLSELLRaAGYRVLVATDGQQALQRAQAEPPDL--ILLDVMMP---GMdgfevcRRLK---ADPATR 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 108 RIPVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19920    72 HIPVIFLTALTDTEDKVKGFELGAVDYITKP 102
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 35-145 2.51e-12

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 63.66  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdIILtEVDLPMAKGMKMLKYVTRDKelRRIPVIMM 114
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDL-VIL-DLGLPDGDGLDLLRRWRRQG--QSLPVLIL 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17624    77 TARDGVDDRVAGLDAGADDYLVKPFALEELL 107
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 34-145 2.87e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 63.61  E-value: 2.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEVFTLLLR--CSYQVISVRSARQVINALNAEGPDIdiILteVDLPMAK--GMKMLKYVTRDKELRRI 109
Cdd:cd17551     2 RILIVD-DNPTNLLLLEALLRsaGYLEVVSFTDPREALAWCRENPPDL--IL--LDYMMPGmdGLEFIRRLRALPGLEDV 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 110 PVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17551    77 PIVMITADTDREVRLRALEAGATDFLTKPFDPVELL 112
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 56-147 3.19e-12

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 63.59  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  56 SYQVISVRSARQVINALNAEG-----PDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMMSAQDEVSVVVKCLRLG 130
Cdd:cd17557    25 PNELHVVRDGEEALDFLRGEGeyadaPRPDLILLDLNMPRMDGFEVLREIKADPDLRRIPVVVLTTSDAEEDIERAYELG 104

                          90
                  ....*....|....*..
gi 1279760864 131 AADYLVKPLRTNELLNL 147
Cdd:cd17557   105 ANSYIVKPVDFEEFVEA 121
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 35-147 7.52e-12

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 62.10  E-value: 7.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEgpDIDIILTEVDLPmakGM------KMLKyvTRDKELR 107
Cdd:cd17546     1 VLVVD-DNPVNRKVLKKLLeKLGYEVDVAENGQEALELLKEE--PFDLVLMDLQMP---VMdgleatRRIR--ELEGGGR 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1279760864 108 RIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:cd17546    73 RTPIIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEV 112
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 34-145 8.48e-12

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 64.21  E-value: 8.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVI-SVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDkelRRIPVI 112
Cdd:COG3707     5 RVLVVDDEPLRRADLREGLREAGYEVVaEAADGEDAVELVRELKPDL--VIVDIDMPDRDGLEAARQISEE---RPAPVI 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 113 MMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:COG3707    80 LLTAYSDPELIERALEAGVSAYLVKPLDPEDLL 112
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 35-157 1.17e-11

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 62.12  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDS---KSSQEVFTLllrCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVT-RDKELrriP 110
Cdd:cd17549     1 VLLVDDDAdvrEALQQTLEL---AGFRVRAFADAEEALAALSPDFPGV--VISDIRMPGMDGLELLAQIReLDPDL---P 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRM 157
Cdd:cd17549    73 VILITGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRRL 119
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 57-145 1.35e-11

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 61.52  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  57 YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMMSAQDEVSVVVKCLRLGAADYLV 136
Cdd:cd19937    22 YEVVTAYDGEEALKRAKDEKPDL--IILDLMLPGIDGLEVCRILRSDPKTSSIPIIMLTAKGEEFDKVLGLELGADDYIT 99


                  ....*....
gi 1279760864 137 KPLRTNELL 145
Cdd:cd19937   100 KPFSPRELL 108
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
34-162 3.62e-11

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 63.20  E-value: 3.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIM 113
Cdd:PRK10161    4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDL--ILLDWMLPGGSGIQFIKHLKRESMTRDIPVVM 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRMLGLTE 162
Cdd:PRK10161   82 LTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEE 130
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 35-145 5.72e-11

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 59.74  E-value: 5.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKElrrIPVIMM 114
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDL--ILLDLMLPEKDGLEVCREVRKTSN---VPIIML 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17614    76 TAKDSEVDKVLGLELGADDYVTKPFSNRELL 106
orf27 CHL00148
Ycf27; Reviewed
 31-170 5.89e-11

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 62.81  E-value: 5.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  31 SKVKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdIILtEVDLPMAKGMKMLKyvtrdkELRR-- 108
Cdd:CHL00148    5 SKEKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDL-VIL-DVMMPKLDGYGVCQ------EIRKes 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1279760864 109 -IPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNEL----LNLWTHIWRRRRMLGLTEKQILNFDF 170
Cdd:CHL00148   77 dVPIIMLTALGDVSDRITGLELGADDYVVKPFSPKELeariRSVLRRTNKKSFSSKIPNSSIIRIGF 143
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 34-138 9.56e-11

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 58.66  E-value: 9.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIM 113
Cdd:cd17538     1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDL--ILLDVMMPGMDGFEVCRRLKEDPETRHIPVIM 78

                          90       100
                  ....*....|....*....|....*
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17538    79 ITALDDREDRIRGLEAGADDFLSKP 103
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 80-145 1.15e-10

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 58.77  E-value: 1.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1279760864  80 DIILTEVDLPMAKGMKMLKYVTRDKElrRIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17625    43 DLIILDIMLPGMDGLEVLKSLREEGI--ETPVLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELL 106
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 35-154 2.64e-10

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 57.70  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELrriPVIMM 114
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDL--VVLDVMLPKMNGLDVLKELRKTSQV---PVLML 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279760864 115 SAQ-DEVSVVVKcLRLGAADYLVKPLRTNELLNLWTHIWRR 154
Cdd:cd17623    76 TARgDDIDRILG-LELGADDYLPKPFNPRELVARIRAILRR 115
PLN03029 PLN03029
type-a response regulator protein; Provisional
 31-164 4.80e-10

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 59.66  E-value: 4.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  31 SKVKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINAL--------NAEGP----------DIDIILTEVDLPMAK 92
Cdd:PLN03029    7 SQFHVLAVDDSLIDRKLIEKLLKTSSYQVTTVDSGSKALKFLglheddrsNPDTPsvspnshqevEVNLIITDYCMPGMT 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1279760864  93 GMKMLKYVTRDKELRRIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRMLGLTEKQ 164
Cdd:PLN03029   87 GYDLLKKIKESSSLRNIPVVIMSSENVPSRITRCLEEGAEEFFLKPVQLSDLNRLKPHMMKTKSKNQKQENQ 158
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
34-144 8.95e-10

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 61.02  E-value: 8.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyVTRDKElRRIPVIM 113
Cdd:PRK11361    6 RILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDV--VLMDIRMPEMDGIKALK-EMRSHE-TRTPVIL 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNEL 144
Cdd:PRK11361   82 MTAYAEVETAVEALRCGAFDYVIKPFDLDEL 112
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 33-145 1.04e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 56.19  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQ-VISVRSARQVINALNAEGpdIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPV 111
Cdd:cd19923     1 MKVLVVDDFSTMRRIIKNLLKELGFNnVEEAEDGVDALEKLKAGG--FDFVITDWNMPNMDGLELLKTIRADGALSHLPV 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLrTNELL 145
Cdd:cd19923    79 LMVTAEAKKENVIAAAQAGVNNYIVKPF-TAATL 111
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 35-145 3.42e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 54.70  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKssqeVFTLLLRC----SYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKelRRIP 110
Cdd:cd17627     1 ILVVDDDRA----VRESLRRSlrfeGYEVETAVDGAEALRVISGNRPDA--VVLDVMMPRLDGLEVCRRLRAAG--NDLP 72

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17627    73 ILVLTARDSVSDRVAGLDAGADDYLVKPFALEELL 107
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 50-145 7.00e-09

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 55.88  E-value: 7.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  50 TLLLRCS-YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyvtrdkELRR----IPVIMMSAQDEVSVVV 124
Cdd:COG4566    16 AFLLESAgLRVETFASAEAFLAALDPDRPGC--LLLDVRMPGMSGLELQE------ELAArgspLPVIFLTGHGDVPMAV 87

                          90       100
                  ....*....|....*....|.
gi 1279760864 125 KCLRLGAADYLVKPLRTNELL 145
Cdd:COG4566    88 RAMKAGAVDFLEKPFDDQALL 108
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 57-147 7.08e-09

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 53.65  E-value: 7.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  57 YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTrdKELRRIPVIMMSAQDEVSVVVKCLRLGAADYLV 136
Cdd:cd17550    23 YEVDTAADGEEALKLIKERRPDL--VLLDIWLPDMDGLELLKEIK--EKYPDLPVIMISGHGTIETAVKATKLGAYDFIE 98

                          90
                  ....*....|.
gi 1279760864 137 KPLRTNELLNL 147
Cdd:cd17550    99 KPLSLDRLLLT 109
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 57-138 8.46e-09

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 53.74  E-value: 8.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  57 YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKElrRIPVIMMSAQDEVSVVVKCLRLGAADYLV 136
Cdd:cd17572    23 YKVTHVETGKEALAFLSDQPPDV--VLLDLKLPDMSGMEILKWIQERSL--PTSVIVITAHGSVDIAVEAMRLGAYDFLE 98


                  ..
gi 1279760864 137 KP 138
Cdd:cd17572    99 KP 100
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
34-154 1.02e-08

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 55.96  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEgpdIDIILTEVDLPMAKGMKMLKyvtrdkELRR---IP 110
Cdd:PRK10955    3 KILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDS---IDLLLLDVMMPKKNGIDTLK------ELRQthqTP 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRR 154
Cdd:PRK10955   74 VIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRR 117
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 34-145 1.47e-08

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 52.83  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKYVTRDKELrriPVIM 113
Cdd:cd17594     1 HVLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHR--RVDLVLLDLRLGQESGLDLLRTIRARSDV---PIII 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 114 MSAQ--DEVSVVVKcLRLGAADYLVKPLRTNELL 145
Cdd:cd17594    76 ISGDrrDEIDRVVG-LELGADDYLAKPFGLRELL 108
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 35-155 1.51e-08

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 53.09  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLRCSYQVISVRSARQ-VINAlnAEGPdIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPVIM 113
Cdd:cd17539     1 VLLVD-DRPSSAERIAAMLSSEHEVVVEADPDEaLFRA--AEGP-FDLVIVSLALEDFDGLRLCSQLRSLERTRQLPILA 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELL-NLWTHIWRRR 155
Cdd:cd17539    77 VADPGDRGRLIRALEIGVNDYLVRPIDPNELLaRVRTQIRRKR 119
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 52-147 1.60e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 52.66  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  52 LLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVtrDKELRRIPVIMMSAQDEVSVVVKCLRLGA 131
Cdd:cd19919    20 LAGAGLTVTSFENAQEALAALASSQPDV--LISDIRMPGMDGLALLAQI--KQRHPDLPVIIMTAHSDLDSAVSAYQGGA 95

                          90
                  ....*....|....*.
gi 1279760864 132 ADYLVKPLRTNELLNL 147
Cdd:cd19919    96 FEYLPKPFDIDEAVAL 111
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 35-146 1.92e-08

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 52.51  E-value: 1.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDndsksSQEVF-----TLL-LRCSYQVIS-VRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRdkELR 107
Cdd:cd17535     1 VLIVD-----DHPLVreglrRLLeSEPDIEVVGeAADGEEALALLRELRPDV--VLMDLSMPGMDGIEALRRLRR--RYP 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1279760864 108 RIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLN 146
Cdd:cd17535    72 DLKVIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIE 110
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
30-144 2.44e-08

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 56.19  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  30 RSKVKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINalNAEGPDIDIILTEVDLPMAKGMKMLKYVtrdKELR-R 108
Cdd:PRK10365    3 HDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALE--QVREQVFDLVLCDVRMAEMDGIATLKEI---KALNpA 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 109 IPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNEL 144
Cdd:PRK10365   78 IPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNL 113
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 35-138 2.82e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 52.00  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINAL-------NAEGPDIDIILTEVDLPMAKGMKMLKYVTRDKELR 107
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLenlakegNDLSKELDLIITDIEMPKMDGYELTFELRDDPRLA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 108 RIPVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19924    81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 34-145 2.99e-08

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 52.09  E-value: 2.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSkSSQEVFTLLLRCS-YQVISVRSARQVINALNAEGPDIdiILTEVDLPmakGMKMLKYVTRDKELRRIPVI 112
Cdd:cd17626     2 RILVVDDDA-ALAEMIGIVLRGEgFDPAFCGDGTQALAAFREVRPDL--VLLDLMLP---GIDGIEVCRQIRAESGVPIV 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 113 MMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17626    76 MLTAKSDTVDVVLGLESGADDYVAKPFKPKELV 108
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 33-145 4.43e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 51.51  E-value: 4.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDnDSKSSQEVFT-LLLRCSYQVI-SVRSARQVINALNAEGPDI---DIILTEVDlpmakGMKMLKYVTR-DKEL 106
Cdd:cd17542     1 KKVLIVD-DAAFMRMMLKdILTKAGYEVVgEAANGEEAVEKYKELKPDLvtmDITMPEMD-----GIEALKEIKKiDPNA 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1279760864 107 RripVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17542    75 K---VIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVL 110
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 80-138 4.53e-08

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 50.90  E-value: 4.53e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1279760864  80 DIILTEVDLPMAKGMKMLKyvtrdkELRR----IPVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19935    44 DLIILDVMLPGLDGLEVLR------RLRAagkqTPVLMLTARDSVEDRVKGLDLGADDYLVKP 100
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 34-145 4.87e-08

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 51.22  E-value: 4.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyvtrdkELRR---IP 110
Cdd:cd19938     1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDL--ILLDLMLPGTDGLTLCR------EIRRfsdVP 72

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 111 VIMMSAQ-DEVSVVVKcLRLGAADYLVKPLRTNELL 145
Cdd:cd19938    73 IIMVTARvEEIDRLLG-LELGADDYICKPYSPREVV 107
pleD PRK09581
response regulator PleD; Reviewed
 10-155 6.03e-08

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 54.91  E-value: 6.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  10 NKDCGVGESNRGGGGAGFvdrSKVKILLCDNDsKSSQEVFTLLLRCSYQVISVRSA-RQVINAlnAEGPdIDIILTEVDL 88
Cdd:PRK09581  136 NAEIGVTALMIMAYANKD---EDGRILLVDDD-VSQAERIANILKEEFRVVVVSDPsEALFNA--AETN-YDLVIVSANF 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1279760864  89 PMAKGMKMLKYVTRDKELRRIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL-NLWTHIWRRR 155
Cdd:PRK09581  209 ENYDPLRLCSQLRSKERTRYVPILLLVDEDDDPRLVKALELGVNDYLMRPIDKNELLaRVRTQIRRKR 276
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 33-147 8.18e-08

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 50.95  E-value: 8.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCdndskssqEVFTlllRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPmakGMKMLKYVTRDKELRR-IPV 111
Cdd:COG5803    14 IRMLLK--------EVLK---KEGYEVFQAANGKEALEKVKELKPDL--VLLDMKMP---GMDGIEILKEIKEIDPdIPV 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:COG5803    78 IMMTAYGELDMVEEAKELGAKGYFTKPFDIDELREA 113
ompR PRK09468
osmolarity response regulator; Provisional
 34-177 9.52e-08

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 53.05  E-value: 9.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSqevfTLLLRC----SYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKyvtrdkELR-- 107
Cdd:PRK09468    7 KILVVDDDMRLR----ALLERYlteqGFQVRSAANAEQMDRLLTRE--SFHLMVLDLMLPGEDGLSICR------RLRsq 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864 108 --RIPVIMMSAQ-DEVSVVVKcLRLGAADYLVKPLRTNELLNLWTHIWRRR--RMLGL--TEKQILNF---DFDLATSDL 177
Cdd:PRK09468   75 nnPTPIIMLTAKgEEVDRIVG-LEIGADDYLPKPFNPRELLARIRAVLRRQapELPGApsQEEEVIAFgkfKLNLGTREL 153
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 32-145 1.10e-07

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 52.90  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  32 KVKILLCDnDSKSSQEVFTLLLRC--SYQVI-SVRSARQVINALNAEGPDI---DIiltevDLPMAKGMKMLKYVtrDKE 105
Cdd:COG3279     1 MMKILIVD-DEPLARERLERLLEKypDLEVVgEASNGEEALELLEEHKPDLvflDI-----QMPGLDGFELARQL--REL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1279760864 106 LRRIPVIMMSAQDEVsvVVKCLRLGAADYLVKPLRTNELL 145
Cdd:COG3279    73 DPPPPIIFTTAYDEY--ALEAFEVNAVDYLLKPIDEERLA 110
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 79-147 1.14e-07

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 50.41  E-value: 1.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  79 IDIILTEVDLPMAKGMKMLKYVtrdKELR-RIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:cd17536    46 PDIVITDIRMPGMDGLELIEKI---RELYpDIKIIILSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEA 112
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 52-138 1.26e-07

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 49.86  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  52 LLRCSYQVISVRSARQVINALNAEGPDIdIILtEVDLPMAKGMKMLKyvtRDKELRRIPVIMMSAQDEVSVVVKCLRLGA 131
Cdd:cd17620    18 LEAHGYRVFEAETGQEGLLEAATRKPDL-IIL-DLGLPDMDGLEVIR---RLREWSAVPVIVLSARDEESDKIAALDAGA 92


                  ....*..
gi 1279760864 132 ADYLVKP 138
Cdd:cd17620    93 DDYLTKP 99
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 34-145 1.82e-07

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 49.68  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyvtrdkELRRI---P 110
Cdd:cd17622     2 RILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDA--VLLDIMLPGIDGLTLCR------DLRPKyqgP 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17622    74 ILLLTALDSDIDHILGLELGADDYVVKPVEPAVLL 108
PRK10610 PRK10610
chemotaxis protein CheY;
33-139 2.12e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 49.97  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQviSVRSARQVINALNA-EGPDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPV 111
Cdd:PRK10610    6 LKFLVVDDFSTMRRIVRNLLKELGFN--NVEEAEDGVDALNKlQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPV 83

                          90       100
                  ....*....|....*....|....*...
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPL 139
Cdd:PRK10610   84 LMVTAEAKKENIIAAAQAGASGYVVKPF 111
PRK11517 PRK11517
DNA-binding response regulator HprR;
33-145 2.28e-07

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 51.82  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINAlnAEGPDIDIILTEVDLPMAKGMKMLKYVTRDKElrrIPVI 112
Cdd:PRK11517    1 MKILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYL--ALKDDYALIILDIMLPGMDGWQILQTLRTAKQ---TPVI 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 113 MMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:PRK11517   76 CLTARDSVDDRVRGLDSGANDYLVKPFSFSELL 108
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 34-147 2.60e-07

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 52.95  E-value: 2.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELrrIPVIM 113
Cdd:PRK10923    5 IVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDV--LLSDIRMPGMDGLALLKQIKQRHPM--LPVII 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:PRK10923   81 MTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVAL 114
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 34-145 3.78e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 48.69  E-value: 3.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEVFTLLLRCS-YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVI 112
Cdd:cd17548     1 KILIVE-DNPLNMKLARDLLESAgYEVLEAADGEEALEIARKEKPDL--ILMDIQLPGMDGLEATRLLKEDPATRDIPVI 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1279760864 113 -----MMSAQDEvsvvvKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17548    78 altayAMKGDRE-----KILEAGCDGYISKPIDTREFL 110
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 35-138 5.22e-07

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 48.14  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMM 114
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDL--IISDIIMPGVDGYSLLGKLRKNADFDTIPVIFL 78

                          90       100
                  ....*....|....*....|....
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19927    79 TAKGMTSDRIKGYNAGCDGYLSKP 102
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 77-138 6.80e-07

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 48.01  E-value: 6.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1279760864  77 PDIDIILTEVDLPMAKGMKMLKYVTRDKelRRIPVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19925    45 RQPDLILLDIYLPDGNGLDLLRELRAAG--HDVDVIVVTAANDVETVREALRLGVVDYLIKP 104
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 33-138 7.54e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 48.16  E-value: 7.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDnDSKSSQEVFTLLLRCS--YQVISV----RSARQVINALNaegPDIdiILTEVDLPMAKGMKMLKYVtrdKEL 106
Cdd:cd17541     1 IRVLIVD-DSAVMRKLLSRILESDpdIEVVGTardgEEALEKIKELK---PDV--ITLDIEMPVMDGLEALRRI---MAE 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 107 RRIPVIMMSA--QDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17541    72 RPTPVVMVSSltEEGAEITLEALELGAVDFIAKP 105
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 35-138 1.02e-06

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 47.11  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALnAEGpDIDIILTEVDLPMAKGMKMLkyvTRDKELR-RIPVIM 113
Cdd:cd19928     1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWV-EEG-EGDLVITDVVMPDENGLDLI---PRIKKARpDLPIIV 75

                          90       100
                  ....*....|....*....|....*
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19928    76 MSAQNTLMTAVKAAERGAFEYLPKP 100
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 35-138 1.03e-06

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 47.05  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIIltEVDLPMAKGMKMLKyvtRDKELRRIPVIMM 114
Cdd:cd19936     1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAIL--DIKMPRMDGMELLQ---RLRQKSTLPVIFL 75

                          90       100
                  ....*....|....*....|....
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19936    76 TSKDDEIDEVFGLRMGADDYITKP 99
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 35-145 1.31e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 47.38  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKyvtrdkELRR---IPV 111
Cdd:cd17619     3 ILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQ--DIDLVLLDINLPGKDGLSLTR------ELREqseVGI 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17619    75 ILVTGRDDEVDRIVGLEIGADDYVTKPFNPRELL 108
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 38-138 1.37e-06

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 46.98  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  38 CDNDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMMSA 116
Cdd:cd17602     3 CVDDRPSIQKMIEYFLeKQGFRVVVIDDPLRALTTLLNSKPDL--ILIDIDMPDLDGYELCSLLRKSSALKDTPIIMLTG 80

                          90       100
                  ....*....|....*....|..
gi 1279760864 117 QDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17602    81 KDGLVDRIRAKMAGASGYLTKP 102
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 35-145 1.39e-06

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 47.28  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMkmlkYVTRdkELRRI---PV 111
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDL--VLLDINLPYFDGF----YWCR--EIRQIsnvPI 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd18159    73 IFISSRDDNMDQVMAINMGGDDYITKPFDLDVLL 106
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 35-145 1.41e-06

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 47.32  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDI---DIILTEVDlpmakGMKMLKYVTRDKELRRIPV 111
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLvisDIVMPEMD-----GYELCRKIKSDPDLKDIPV 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17598    76 ILLTTLSDPRDVIRGLECGADNFITKPYDEKYLL 109
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 35-145 2.40e-06

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 46.51  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIIltEVDLPMAKGMKMLKYVtRDKElRRIPVIMM 114
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVL--DLGLPGMDGLSVLRRW-RSEG-RATPVLIL 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 115 SAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd19934    77 TARDSWQDKVEGLDAGADDYLTKPFHIEELL 107
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 82-147 2.69e-06

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 46.43  E-value: 2.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1279760864  82 ILTEVDLPmakGMKMLKYVTRDKELR-RIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:cd17537    48 LVLDVRMP---GMSGLELQDELLARGsNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDA 111
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 35-138 5.69e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 45.03  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALnAEGPDIDIILTevDLPMAKGMKMLKYVTRDKELR-RIPVIM 113
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLL-ESGPDIDLLVT--DVIMPGGMNGSQLAEEARRRRpDLKVLL 77

                          90       100
                  ....*....|....*....|....*.
gi 1279760864 114 MSAQDEVSVVVKclRLGA-ADYLVKP 138
Cdd:cd18161    78 TSGYAENAIEGG--DLAPgVDVLSKP 101
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 35-147 9.39e-06

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 44.76  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLR-CSYQVISVRSARQVINALNAEGPdiDIILTEVDLPMAKGMKMLKYVTRDKELRRIPVIM 113
Cdd:cd17580     1 ILVVD-DNEDAAEMLALLLElEGAEVTTAHSGEEALEAAQRFRP--DVILSDIGMPGMDGYELARRLRELPWLANTPAIA 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 114 MS--AQDEvsVVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:cd17580    78 LTgyGQPE--DRERALEAGFDAHLVKPVDPDELIEL 111
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 81-137 1.34e-05

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 44.71  E-value: 1.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1279760864  81 IILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMMSAQDEVSVVVKCLRLGAADYLVK 137
Cdd:cd17575    48 VILQDLVMPGVDGLTLVRFFRANPATRDIPIIVLSTKEEPEVKSEAFALGANDYLVK 104
pleD PRK09581
response regulator PleD; Reviewed
 57-145 1.62e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 47.20  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  57 YQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPVIMMSAQDEVSVVVKCLRLGAADYLV 136
Cdd:PRK09581   27 YTVLTASSGAEAIAICEREQPDI--ILLDVMMPGMDGFEVCRRLKSDPATTHIPVVMVTALDDPEDRVRGLEAGADDFLT 104


                  ....*....
gi 1279760864 137 KPLRTNELL 145
Cdd:PRK09581  105 KPINDVALF 113
PRK10693 PRK10693
two-component system response regulator RssB;
80-140 1.76e-05

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 46.91  E-value: 1.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1279760864  80 DIILTEVDLPMAKGMKMLKYVtRDKELRrIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLR 140
Cdd:PRK10693   19 DLIICDLAMPRMNGIEFVEHL-RNRGDQ-TPVLVISATENMADIAKALRLGVQDVLLKPVK 77
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 33-138 1.76e-05

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 43.93  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIDIILTEVDLPMAKG----MKMLKYVTRdkelRR 108
Cdd:cd19933     1 LKVLLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLNLLASAEHSFQLVLLDLCMPEMDGfevaLRIRKLFGR----RE 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1279760864 109 IPVIM-MSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd19933    77 RPLIVaLTANTDDSTREKCLSLGMNGVITKP 107
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 34-154 2.05e-05

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 43.90  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVtrdKELRRIPVIM 113
Cdd:cd19939     1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSL--VVLDIMLPGMDGLTVCREV---REHSHVPILM 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRR 154
Cdd:cd19939    76 LTARTEEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
PRK10643 PRK10643
two-component system response regulator PmrA;
34-174 2.41e-05

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 45.80  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKYVTRDKElrRIPVIM 113
Cdd:PRK10643    2 KILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESG--HYSLVVLDLGLPDEDGLHLLRRWRQKKY--TLPVLI 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1279760864 114 MSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRRMLGLTEKQILNFDFDLAT 174
Cdd:PRK10643   78 LTARDTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQGENELQVGNLTLNLGR 138
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 80-180 2.65e-05

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 45.57  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  80 DIILTEVDLPMAKGMKMLKyvtrdkELRR---IPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLwTHIWRRRR 156
Cdd:PRK10529   47 DLIILDLGLPDGDGIEFIR------DLRQwsaIPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQAR-LRVALRRH 119

                          90       100
                  ....*....|....*....|....
gi 1279760864 157 MLGLTEKQILNFDfDLaTSDLSDR 180
Cdd:PRK10529  120 SATPAPDPLVKFS-DV-TVDLAAR 141
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 34-154 2.68e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 43.50  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEVFTLLLRcsYQVISVRSA---RQVINALNAEGPDIdIILtEVDLPMAKGMKMLKYVTRDkeLRRIP 110
Cdd:cd17615     1 RVLVVD-DEPNITELLSMALR--YEGWDVETAadgAEALAAAREFRPDA-VVL-DIMLPDMDGLEVLRRLRAD--GPDVP 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1279760864 111 VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRR 154
Cdd:cd17615    74 VLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 35-138 3.32e-05

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 42.96  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKyvtrdkELR---RIPV 111
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADI--VLLDLMLPGLSGTEVCR------QLRarsNVPV 72

                          90       100
                  ....*....|....*....|....*...
gi 1279760864 112 IMMSAQD-EVSVVVKcLRLGAADYLVKP 138
Cdd:cd17621    73 IMVTAKDsEIDKVVG-LELGADDYVTKP 99
dpiA PRK10046
two-component response regulator DpiA; Provisional
 81-165 3.40e-05

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 45.39  E-value: 3.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  81 IILTEVDLPMAKGMKMLKyvtrdkELR--RIP--VIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRRRR 156
Cdd:PRK10046   53 LILLDNYLPDGRGINLLH------ELVqaHYPgdVVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKH 126

                          90
                  ....*....|...
gi 1279760864 157 ML----GLTEKQI 165
Cdd:PRK10046  127 MLesidSASQKQI 139
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 78-191 3.72e-05

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 45.30  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  78 DIDIILTEVDLPMAKG---MKMLKYVTRDkelrrIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL-NLWTHIWR 153
Cdd:PRK09836   44 DYDLIILDIMLPDVNGwdiVRMLRSANKG-----MPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLaRVRTLLRR 118

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1279760864 154 RRRMLGLTEKQILNFDFDLATSDLSdRNTNSTTFLSDD 191
Cdd:PRK09836  119 GAAVIIESQFQVADLMVDLVSRKVT-RSGTRITLTSKE 155
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 33-145 3.97e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 43.17  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALnAEGPDIDIILTEVDLPMAKGMKMLKYVTRDkelRRIPVI 112
Cdd:cd19932     1 VRVLIAEDEALIRMDLREMLEEAGYEVVGEASDGEEAVEL-AKKHKPDLVIMDVKMPRLDGIEAAKIITSE---NIAPIV 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 113 MMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd19932    77 LLTAYSQQDLVERAKEAGAMAYLVKPFSESDLI 109
PRK10336 PRK10336
two-component system response regulator QseB;
33-139 4.02e-05

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 44.89  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  33 VKILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAeGPdIDIILTEVDLPMAKGMKMLKYvTRDKElRRIPVI 112
Cdd:PRK10336    1 MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYS-AP-YDAVILDLTLPGMDGRDILRE-WREKG-QREPVL 76

                          90       100
                  ....*....|....*....|....*..
gi 1279760864 113 MMSAQDEVSVVVKCLRLGAADYLVKPL 139
Cdd:PRK10336   77 ILTARDALAERVEGLRLGADDYLCKPF 103
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 34-145 4.84e-05

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 44.14  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDskssqEVFTLLL-----RCSYQVISVRSARQVINALNAEGPDIDIilteVDLPMAkGMKMLKYVTRDKELR- 107
Cdd:COG4567     6 SLLLVDDD-----EAFARVLaraleRRGFEVTTAASVEEALALLEQAPPDYAV----LDLRLG-DGSGLDLIEALRERDp 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1279760864 108 RIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:COG4567    76 DARIVVLTGYASIATAVEAIKLGADDYLAKPADADDLL 113
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 35-145 4.85e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 42.78  E-value: 4.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVrsarqvinALNAEGPDI------DIILTEVDLPMAKGMKMLKYVTRDKElrR 108
Cdd:cd17616     1 VLLIEDDSATAQSIELMLKSEGFNVYTT--------DLGEEGLDLgklydyDIILLDLNLPDMSGYEVLRTLRLAKV--K 70

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1279760864 109 IPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17616    71 TPILILSGLADIEDKVKGLGFGADDYMTKPFHKDELV 107
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 34-138 5.79e-05

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 42.54  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEV--FTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTRDKELRRIPV 111
Cdd:cd17552     3 RILVID-DEEDIREVvqACLEKLAGWEVLTASSGQEGLEKAATEQPDA--ILLDVMMPDMDGLATLKKLQANPETQSIPV 79

                          90       100
                  ....*....|....*....|....*..
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17552    80 ILLTAKAQPSDRQRFASLGVAGVIAKP 106
fixJ PRK09390
response regulator FixJ; Provisional
 82-138 6.87e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 43.84  E-value: 6.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1279760864  82 ILTEVDLPMAKGMKMLKyvtRDKELR-RIPVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:PRK09390   51 VVTDVRMPGIDGIELLR---RLKARGsPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKP 105
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 32-138 8.87e-05

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 41.83  E-value: 8.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  32 KVKILLCDnDSKSSQEVFT--LLLRCSYQVISVRS-ARQVINALNAEGPDI---DIILTEVDlpmakGMKMLKYVTRDKE 105
Cdd:cd17561     1 KIKVLIAD-DNREFVQLLEeyLNSQPDMEVVGVAHnGQEALELIEEKEPDVlllDIIMPHLD-----GIGVLEKLRRMRL 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 106 LRRIPVIMMSAQDEVSVVVKCLRLGAADYLVKP 138
Cdd:cd17561    75 EKRPKIIMLTAFGQEDITQRAVELGASYYILKP 107
PRK10766 PRK10766
two-component system response regulator TorR;
57-153 2.12e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 42.72  E-value: 2.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  57 YQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMkMLkyvTRdkELRR---IPVIMMSAQDEVSVVVKCLRLGAAD 133
Cdd:PRK10766   27 YTVSEAASGAGMREIMQNQ--HVDLILLDINLPGEDGL-ML---TR--ELRSrstVGIILVTGRTDSIDRIVGLEMGADD 98

                          90       100
                  ....*....|....*....|....
gi 1279760864 134 YLVKPLRTNELL----NLwthIWR 153
Cdd:PRK10766   99 YVTKPLELRELLvrvkNL---LWR 119
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 31-138 2.19e-04

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 43.25  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  31 SKVKILLCDNDskssqEVFTLLLRCS------YQVISV-RSARQVINALNAEGPDI---DIILTEVDlpmakGMKMLKYV 100
Cdd:COG5801     3 EKIKVLIADDN-----REFCELLEEYlssqpdMEVVGVaYNGLEALELIEEKKPDVvilDIIMPHLD-----GLGVLEKL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1279760864 101 TRDKELRRIPVIMMSA--QDEVsvVVKCLRLGAADYLVKP 138
Cdd:COG5801    73 REMNLEKRPKVIMLTAfgQEDI--TQRAVELGADYYILKP 110
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 52-138 2.36e-04

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 40.60  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  52 LLRCSYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKYVtrDKELRRIPVIMMSAQDEVSVVVKCLRLGA 131
Cdd:cd19926    18 LGRMGLDVRSARNVKEARELLASE--PYDLCLTDMRLPDGSGLELVQHI--QQRLPQTPVAVITAYGSLDTAIEALKAGA 93


                  ....*..
gi 1279760864 132 ADYLVKP 138
Cdd:cd19926    94 FDFLTKP 100
PRK10430 PRK10430
two-component system response regulator DcuR;
54-148 2.48e-04

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 42.79  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  54 RCSYQVISVRSARQVINalNAEGPdIDIILTEVDLPMAKGMKMLKYVTRDKelRRIPVIMMSAQDEVSVVVKCLRLGAAD 133
Cdd:PRK10430   28 QCCGTASTLEQAKEIIF--NSDTP-IDLILLDIYMQQENGLDLLPVLHEAG--CKSDVIVISSAADAATIKDSLHYGVVD 102

                          90
                  ....*....|....*...
gi 1279760864 134 YLVKPL---RTNELLNLW 148
Cdd:PRK10430  103 YLIKPFqasRFEEALTGW 120
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 29-144 2.91e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 40.62  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  29 DRSKVKILLcdndskssQEVFTlllRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMKMLKYVTR-DKELR 107
Cdd:cd17553     8 DQYGIRILL--------NEVFN---KEGYQTFQAANGLQALDIVTKERPDL--VLLDMKIPGMDGIEILKRMKViDENIR 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1279760864 108 ripVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNEL 144
Cdd:cd17553    75 ---VIIMTAYGELDMIQESKELGALTHFAKPFDIDEI 108
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 35-145 5.06e-04

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 41.72  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKYVTRDKElrrIPVIMM 114
Cdd:PRK13856    4 VLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASE--TVDVVVVDLNLGREDGLEIVRSLATKSD---VPIIII 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1279760864 115 SAQ--DEVSVVVkCLRLGAADYLVKPLRTNELL 145
Cdd:PRK13856   79 SGDrlEEADKVV-ALELGATDFIAKPFGTREFL 110
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 34-89 5.07e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 38.32  E-value: 5.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1279760864   34 KILLCDnDSKSSQEVFTLLL-RCSYQVISVRSARQVINALNAEGPdiDIILTEVDLP 89
Cdd:smart00448   2 RILVVD-DDPLLRELLKALLeKEGYEVDEATDGEEALELLKEEKP--DLILLDIMMP 55
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 34-145 6.50e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 39.59  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEVFTLLLR-CSYQVISVRSARQvinALN-AEGPDIDIILTEVDLPMAKGMKMLKYVTRDKELRRIPV 111
Cdd:cd17562     2 KILAVD-DSASIRQMVSFTLRgAGYEVVEAADGRD---ALSkAQSKKFDLIITDQNMPNMDGIELIKELRKLPAYKFTPI 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1279760864 112 IMMS--AQDEVSVVVKclRLGAADYLVKPLRTNELL 145
Cdd:cd17562    78 LMLTteSSDEKKQEGK--AAGATGWLVKPFDPEQLL 111
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 35-145 6.71e-04

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 39.34  E-value: 6.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQ---VISVRSARQVINALNaegpdIDIILTEVDLPMAKGMKMLKYVTRDKElrRIPV 111
Cdd:cd17573     1 ILLIEDDSTLGKEISKGLNEKGYQadvAESLKDGEYYIDIRN-----YDLVLVSDKLPDGNGLSIVSRIKEKHP--SIVV 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17573    74 IVLSDNPKTEQEIEAFKEGADDYIAKPFDFKVLV 107
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 74-145 1.23e-03

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 40.40  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1279760864  74 AEGPDIDIILTEVDLPMAKGMKMLKYVtRDKELR-RIpvIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:PRK10651   48 AESLDPDLILLDLNMPGMNGLETLDKL-REKSLSgRI--VVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLL 117
PRK15479 PRK15479
transcriptional regulator TctD;
85-144 1.63e-03

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 40.09  E-value: 1.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1279760864  85 EVDLPmakGMKMLKYVTRdkeLRR----IPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNEL 144
Cdd:PRK15479   51 DINMP---GMDGLEVLQR---LRKrgqtLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEEL 108
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
65-138 1.86e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 40.52  E-value: 1.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1279760864  65 ARQVINALNaegpdIDIILTEVDLPMAKGMKMLKYVTRdkeLRRIPVIMMSA--QDEVSVVVKCLRLGAADYLVKP 138
Cdd:PRK00742   41 AREKIKKLN-----PDVITLDVEMPVMDGLDALEKIMR---LRPTPVVMVSSltERGAEITLRALELGAVDFVTKP 108
PRK10816 PRK10816
two-component system response regulator PhoP;
57-178 2.36e-03

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 39.72  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  57 YQVISVRSARQVINALNAEGPDIDIIltEVDLPMAKGMKMLKYVTRDKElrRIPVIMMSAQDEVSVVVKCLRLGAADYLV 136
Cdd:PRK10816   25 HQVDAAEDAKEADYYLNEHLPDIAIV--DLGLPDEDGLSLIRRWRSNDV--SLPILVLTARESWQDKVEVLSAGADDYVT 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1279760864 137 KPLRTNELLNLWTHIWRRRRMLGLTEKQILNFDFDLATSDLS 178
Cdd:PRK10816  101 KPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELS 142
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 34-145 3.66e-03

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 37.39  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDNDSKSSQEVFTLLLRCSYQVI-SVRSARQVINALNAEGPDIdiILTEVDLpmaKG-------MKMLKyvtrdkE 105
Cdd:cd17534     2 KILIVEDEAIIALDLKEILESLGYEVVgIADSGEEAIELAEENKPDL--ILMDINL---KGdmdgieaAREIR------E 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1279760864 106 LRRIPVIMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELL 145
Cdd:cd17534    71 KFDIPVIFLTAYSDEETLERAKETNPYGYLVKPFNERELK 110
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 35-154 3.98e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 38.90  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDNDSKSSQEVFTLLLRCSYQVISVRSARQVINALNAEGPDIdiILTEVDLPMAKGMkmlkyvTRDKELRR---IPV 111
Cdd:PRK10710   13 ILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDL--ILLDLMLPGTDGL------TLCREIRRfsdIPI 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1279760864 112 IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNELLNLWTHIWRR 154
Cdd:PRK10710   85 VMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRR 127
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 34-147 6.71e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 36.75  E-value: 6.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  34 KILLCDnDSKSSQEvftLLLRC-----SYQVISVRSARQVINALNAEgpDIDIILTEVDLPMAKGMKMLKYVtRDKELRr 108
Cdd:cd17593     2 KVLICD-DSSMARK---QLARAlpadwDVEITFAENGEEALEILREG--RIDVLFLDLTMPVMDGYEVLEAL-PVEQLE- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1279760864 109 IPVIMMSA--QDEVsvVVKCLRLGAADYLVKPLRTNELLNL 147
Cdd:cd17593    74 TKVIVVSGdvQPEA--KERVLELGALAFLKKPFDPEKLAQL 112
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 35-144 7.85e-03

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 36.47  E-value: 7.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1279760864  35 ILLCDnDSKSSQEVFTLLLRcSYQVISVR---SARQVINALNAEgpDIDIILTEVDLPMAK-GMKMLKYVTRDKELRRIP 110
Cdd:cd17589     1 FLIVD-DQPTFRSMLKSMLR-SLGVTRIDtasSGEEALRMCENK--TYDIVLCDYNLGKGKnGQQLLEELRHKKLISPST 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1279760864 111 V-IMMSAQDEVSVVVKCLRLGAADYLVKPLRTNEL 144
Cdd:cd17589    77 VfIMVTGESSRAMVLSALELEPDDYLLKPFTVSEL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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