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Conserved domains on  [gi|1229788136|ref|XP_022147456|]
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mediator of RNA polymerase II transcription subunit 12 [Momordica charantia]

Protein Classification

mediator of RNA polymerase II transcription subunit 12( domain architecture ID 10559989)

mediator of RNA polymerase II transcription subunit 12 (MED12) plays a key role in the Mediator complex and directly moderates receptor tyrosine kinase, nuclear receptor and Wnt pathway signaling.

Gene Ontology:  GO:0016592|GO:0003713
PubMed:  24123922

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med12 pfam09497
Transcription mediator complex subunit Med12; Med12 is a negative regulator of the ...
 159-219 1.93e-22

Transcription mediator complex subunit Med12; Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.


:

Pssm-ID: 462818  Cd Length: 63  Bit Score: 92.59  E-value: 1.93e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1229788136  159 FPEQRPCGEDFRKKWIEGLSQQHKRLRSLADNVPHGYRKRALFEVLIRNNVPLLRATWFIK 219
Cdd:pfam09497    3 PPPRVTLTDTKREAWLRDLANPNVPLSKLSKKIPHGLKGKKLLEQLCSKNVPIPRAIWFIK 63
 
Name Accession Description Interval E-value
Med12 pfam09497
Transcription mediator complex subunit Med12; Med12 is a negative regulator of the ...
 159-219 1.93e-22

Transcription mediator complex subunit Med12; Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.


Pssm-ID: 462818  Cd Length: 63  Bit Score: 92.59  E-value: 1.93e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1229788136  159 FPEQRPCGEDFRKKWIEGLSQQHKRLRSLADNVPHGYRKRALFEVLIRNNVPLLRATWFIK 219
Cdd:pfam09497    3 PPPRVTLTDTKREAWLRDLANPNVPLSKLSKKIPHGLKGKKLLEQLCSKNVPIPRAIWFIK 63
 
Name Accession Description Interval E-value
Med12 pfam09497
Transcription mediator complex subunit Med12; Med12 is a negative regulator of the ...
 159-219 1.93e-22

Transcription mediator complex subunit Med12; Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.


Pssm-ID: 462818  Cd Length: 63  Bit Score: 92.59  E-value: 1.93e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1229788136  159 FPEQRPCGEDFRKKWIEGLSQQHKRLRSLADNVPHGYRKRALFEVLIRNNVPLLRATWFIK 219
Cdd:pfam09497    3 PPPRVTLTDTKREAWLRDLANPNVPLSKLSKKIPHGLKGKKLLEQLCSKNVPIPRAIWFIK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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