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Conserved domains on  [gi|1229750575|ref|XP_022142780|]
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transcription factor IIIB 90 kDa subunit-like isoform X1 [Momordica charantia]

Protein Classification

transcription factor IIIB subunit( domain architecture ID 10544075)

transcription factor IIIB subunit is a component of TFIIIB complexes that act as general activators of RNA polymerase (RNAP) transcription; RNAP utilizes different TFIIIB complexes at structurally distinct promoters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRF1 pfam07741
Brf1-like TBP-binding domain; In budding yeasts, Brf1 forms the TFIIIB complex with ...
 31-128 5.50e-20

Brf1-like TBP-binding domain; In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling. This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions.


:

Pssm-ID: 462250 [Multi-domain]  Cd Length: 98  Bit Score: 80.68  E-value: 5.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229750575  31 DILESEVNLYLNNEKEARYKKIIWEKINKDYLQEQAAKKQGRDVAGAAHvVKKSKKRQRKKEAATNTPAEADTEATREML 110
Cdd:pfam07741   2 DLDDDELDNYILSEEEVKIKERIWVELNKDYLEEQAEKRLKAEAAEAAG-KPKKKRKRKKKEKKNIGPASTAAEAAKNML 80

                          90
                  ....*....|....*...
gi 1229750575 111 TKKRLSSKVNFDVLDELF 128
Cdd:pfam07741  81 KKKKFSKKINYDALKSLF 98
 
Name Accession Description Interval E-value
BRF1 pfam07741
Brf1-like TBP-binding domain; In budding yeasts, Brf1 forms the TFIIIB complex with ...
 31-128 5.50e-20

Brf1-like TBP-binding domain; In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling. This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions.


Pssm-ID: 462250 [Multi-domain]  Cd Length: 98  Bit Score: 80.68  E-value: 5.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229750575  31 DILESEVNLYLNNEKEARYKKIIWEKINKDYLQEQAAKKQGRDVAGAAHvVKKSKKRQRKKEAATNTPAEADTEATREML 110
Cdd:pfam07741   2 DLDDDELDNYILSEEEVKIKERIWVELNKDYLEEQAEKRLKAEAAEAAG-KPKKKRKRKKKEKKNIGPASTAAEAAKNML 80

                          90
                  ....*....|....*...
gi 1229750575 111 TKKRLSSKVNFDVLDELF 128
Cdd:pfam07741  81 KKKKFSKKINYDALKSLF 98
 
Name Accession Description Interval E-value
BRF1 pfam07741
Brf1-like TBP-binding domain; In budding yeasts, Brf1 forms the TFIIIB complex with ...
 31-128 5.50e-20

Brf1-like TBP-binding domain; In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling. This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions.


Pssm-ID: 462250 [Multi-domain]  Cd Length: 98  Bit Score: 80.68  E-value: 5.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229750575  31 DILESEVNLYLNNEKEARYKKIIWEKINKDYLQEQAAKKQGRDVAGAAHvVKKSKKRQRKKEAATNTPAEADTEATREML 110
Cdd:pfam07741   2 DLDDDELDNYILSEEEVKIKERIWVELNKDYLEEQAEKRLKAEAAEAAG-KPKKKRKRKKKEKKNIGPASTAAEAAKNML 80

                          90
                  ....*....|....*...
gi 1229750575 111 TKKRLSSKVNFDVLDELF 128
Cdd:pfam07741  81 KKKKFSKKINYDALKSLF 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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