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Conserved domains on  [gi|1207107939|ref|XP_021333863|]
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uncharacterized protein LOC103909484 [Danio rerio]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10309807)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to matrix remodeling-associated protein 8 which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 121-219 1.21e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.77  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 121 SKRVTVNSGETAVFSCEYS------HNQINHAKVILKPERDSIEMIYSTLN----KQDRFSISDDRQRNSFSVSITAVTA 190
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSssmseaSTSVYWYRQPPGKGPTFLIAYYSNGSeegvKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*....
gi 1207107939 191 GDGGVYLCGVWVNKHSYSyyiTNTVHLQI 219
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVF---GKGTRLTV 108
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 24-96 5.03e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05716:

Pssm-ID: 472250  Cd Length: 100  Bit Score: 38.53  E-value: 5.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207107939  24 TGYSGGSLMLD-SGKLWVSDSAKYLAKLPDWR-TIINDTkhERWINEGRFTLFKNND-GNLMIFIRDLNTDDAGRY 96
Cdd:cd05716     8 TGVEGGSVTIQcPYPPKYASSRKYWCKWGSEGcQTLVSS--EGVVPGGRISLTDDPDnGVFTVTLNQLRKEDAGWY 81
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 121-219 1.21e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.77  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 121 SKRVTVNSGETAVFSCEYS------HNQINHAKVILKPERDSIEMIYSTLN----KQDRFSISDDRQRNSFSVSITAVTA 190
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSssmseaSTSVYWYRQPPGKGPTFLIAYYSNGSeegvKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*....
gi 1207107939 191 GDGGVYLCGVWVNKHSYSyyiTNTVHLQI 219
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVF---GKGTRLTV 108
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 124-218 3.61e-09

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 53.17  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 124 VTVNSGETAVFSCEYSHNQINHAKVILKPERDSIEMIYSTLNKQD--RFSISDDRQRNSFSVSITAVTAGDGGVYLCGVW 201
Cdd:cd05716     7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPggRISLTDDPDNGVFTVTLNQLRKEDAGWYWCGVG 86

                          90
                  ....*....|....*..
gi 1207107939 202 VNKHsysYYITNTVHLQ 218
Cdd:cd05716    87 DDGD---RGLTVQVKLV 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 121-215 1.59e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.97  E-value: 1.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939  121 SKRVTVNSGETAVFSCEYSHNqiNHAKVILKpeRDSIEMIYStlnkQDRFSISddRQRNSFSVSITAVTAGDGGVYLCGV 200
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS--PPPEVTWY--KQGGKLLAE----SGRFSVS--RSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|....*
gi 1207107939  201 WVNKHSYSYYITNTV 215
Cdd:smart00410  71 TNSSGSASSGTTLTV 85
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-96 5.03e-04

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 38.53  E-value: 5.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207107939  24 TGYSGGSLMLD-SGKLWVSDSAKYLAKLPDWR-TIINDTkhERWINEGRFTLFKNND-GNLMIFIRDLNTDDAGRY 96
Cdd:cd05716     8 TGVEGGSVTIQcPYPPKYASSRKYWCKWGSEGcQTLVSS--EGVVPGGRISLTDDPDnGVFTVTLNQLRKEDAGWY 81
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 121-219 1.21e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.77  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 121 SKRVTVNSGETAVFSCEYS------HNQINHAKVILKPERDSIEMIYSTLN----KQDRFSISDDRQRNSFSVSITAVTA 190
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSssmseaSTSVYWYRQPPGKGPTFLIAYYSNGSeegvKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*....
gi 1207107939 191 GDGGVYLCGVWVNKHSYSyyiTNTVHLQI 219
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVF---GKGTRLTV 108
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 124-218 3.61e-09

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 53.17  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 124 VTVNSGETAVFSCEYSHNQINHAKVILKPERDSIEMIYSTLNKQD--RFSISDDRQRNSFSVSITAVTAGDGGVYLCGVW 201
Cdd:cd05716     7 VTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPggRISLTDDPDNGVFTVTLNQLRKEDAGWYWCGVG 86

                          90
                  ....*....|....*..
gi 1207107939 202 VNKHsysYYITNTVHLQ 218
Cdd:cd05716    87 DDGD---RGLTVQVKLV 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 121-215 1.59e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.97  E-value: 1.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939  121 SKRVTVNSGETAVFSCEYSHNqiNHAKVILKpeRDSIEMIYStlnkQDRFSISddRQRNSFSVSITAVTAGDGGVYLCGV 200
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS--PPPEVTWY--KQGGKLLAE----SGRFSVS--RSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|....*
gi 1207107939  201 WVNKHSYSYYITNTV 215
Cdd:smart00410  71 TNSSGSASSGTTLTV 85
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 124-200 7.31e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 41.10  E-value: 7.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 124 VTVNSGETAVFSCEYSHNQINHakvIL----KPERDSIEMIYSTLNKQ----DRFSISDDRQRNSFSVSITAVTAGDGGV 195
Cdd:cd04983     8 LSVQEGENVTLNCNYSTSTFYY---LFwyrqYPGQGPQFLIYISSDSGnkkkGRFSATLDKSRKSSSLHISAAQLSDSAV 84


                  ....*
gi 1207107939 196 YLCGV 200
Cdd:cd04983    85 YFCAL 89
IGv smart00406
Immunoglobulin V-Type;
131-200 1.23e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 39.67  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939  131 TAVFSCEYSHNQINHAKV--ILKPERDSIE-MIYSTLNKQ--------DRFSISDDRQRNSFSVSITAVTAGDGGVYLCG 199
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVswVRQPPGKGLEwLGYIGSNGSsyyqesykGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80


                   .
gi 1207107939  200 V 200
Cdd:smart00406  81 V 81
IgV_1_Necl-2 cd05881
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2; member of the ...
 120-209 4.04e-04

First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of nectin-like molecule-2, Necl-2 (also known as cell adhesion molecule 1 (CADM1), SynCAM1, IGSF4A, Tslc1, sgIGSF, and RA175). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 - Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region, belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-2 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma.


Pssm-ID: 409465  Cd Length: 94  Bit Score: 38.83  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 120 MSKRVTVNSGETAVFSCEYSHNQiNHAKVILKPERDSIEMIYSTLNKQDRFSISdDRQRNSFSVSITAVTAGDGGVYLCG 199
Cdd:cd05881     2 VTEDVTVVEGEVATISCRVKNSD-DSVIQLLNPNRQTIYFRDFRPLKDSRFQLV-NFSSSELRVSLTNVSISDEGRYFCQ 79

                          90
                  ....*....|
gi 1207107939 200 VWVNKHSYSY 209
Cdd:cd05881    80 LYTDPPQEAY 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-96 5.03e-04

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 38.53  E-value: 5.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207107939  24 TGYSGGSLMLD-SGKLWVSDSAKYLAKLPDWR-TIINDTkhERWINEGRFTLFKNND-GNLMIFIRDLNTDDAGRY 96
Cdd:cd05716     8 TGVEGGSVTIQcPYPPKYASSRKYWCKWGSEGcQTLVSS--EGVVPGGRISLTDDPDnGVFTVTLNQLRKEDAGWY 81
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 124-209 1.06e-03

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 37.83  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 124 VTVNSGETAVFSCeySHNQINHAKVIL-----KPERDSIEMIYstLNKQ------DRFSISDDRqrNSFSVSITAVTAGD 192
Cdd:cd04984     8 LSVSPGETVTITC--TGSSGNISGNYVnwyqqKPGSAPRYLIY--EDKHrpsgipDRFSGSKSG--NTASLTISGAQTED 81

                          90
                  ....*....|....*..
gi 1207107939 193 GGVYLCGVWvnkHSYSY 209
Cdd:cd04984    82 EADYYCQVW---DSNSY 95
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
 119-198 3.36e-03

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 35.95  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 119 NMSKRVTVNSGETAVFSCEYSHNQINHAKvILKPERDSIEMIYSTLNKQDRFSISDDRQrNSFSVSITAVTAGDGGVYLC 198
Cdd:cd05717     1 PHTQDVTVVEGETLTLKCQVSLRDDSSLQ-WLNPNGQTIYFNDKRALRDSRYQLLNHSA-SELSISVSNVTLSDEGVYTC 78
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 124-212 5.36e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.25  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 124 VTVNSGETAVFSCEYSHNQINhAKVILKPERDSIEmiystlnkQDRFSISDDRQRNSFSVSITAVTAGDGGVYLCGVWVN 203
Cdd:pfam00047   6 VTVLEGDSATLTCSASTGSPG-PDVTWSKEGGTLI--------ESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNP 76


                  ....*....
gi 1207107939 204 KHSYSYYIT 212
Cdd:pfam00047  77 GGSATLSTS 85
I-set pfam07679
Immunoglobulin I-set domain;
121-198 8.10e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 34.93  E-value: 8.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207107939 121 SKRVTVNSGETAVFSCeyshnqinhaKVILKPErDSIEMIY--STLNKQDRFSISDDRQRNSFsvSITAVTAGDGGVYLC 198
Cdd:pfam07679   7 PKDVEVQEGESARFTC----------TVTGTPD-PEVSWFKdgQPLRSSDRFKVTYEGGTYTL--TISNVQPDDSGKYTC 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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