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Conserved domains on  [gi|1196702590|ref|XP_021101574|]
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calcium permeable stress-gated cation channel 1 isoform X2 [Heterocephalus glaber]

Protein Classification

OSCA/TMEM63 family ion channel( domain architecture ID 10342091)

OSCA/TMEM63 family ion channel is an an osmosensitive calcium-permeable cation channel that converts mechanical stimuli into electric signals

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
427-681 4.06e-56

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


:

Pssm-ID: 460661  Cd Length: 273  Bit Score: 193.89  E-value: 4.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 427 PAIIINTIDMYNVTRPIEKLQSP----------VVTQFFPSLLLWAFTVIMPLMVYFSAFLEAHWTRSSQNLIIVHKCYI 496
Cdd:pfam02714  19 PVAFVGLLSNLETLTKVWPFLKWilelppkllgLVTGLLPPLLLSLLMALLPIILRFLSKLQGAPSRSDIELSVQSKYFA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 497 FLVFMVVILPSMGLTSLDVFLrwlfDIYYLEQATIRFQCVFLPDNGAFFINYVITAALLGTGMELMRLGSLFMYSTRLFF 576
Cdd:pfam02714  99 FLVVNVFLVFTLASSASSLIE----QIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQLGPLILFYIKRKF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 577 SRSEPERVHIRKNQAIEFQYGREYAWMMNVFTVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSYAPTKLSEQIHMaa 656
Cdd:pfam02714 175 LDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVYVTKYESGGRFW-- 252
                         250       260
                  ....*....|....*....|....*
gi 1196702590 657 vsqaIFAPLLGLFWMLFFSILRAGY 681
Cdd:pfam02714 253 ----PRALNRLLVGLYLFQLCLIGL 273
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
220-398 5.45e-49

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


:

Pssm-ID: 464272  Cd Length: 164  Bit Score: 170.20  E-value: 5.45e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 220 RTLMITYVPTDIQDPEMVIKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGRVmIRIHPCARL 299
Cdd:pfam14703   2 RTVLVTGIPKDLRSEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK-PKKRPTHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 300 CFCKCWtcFKEVDAEQYYSELEEQLTDEFNAELNRVRLKRLDLIFVTFQDSRMAQRVqedykyihcgvhpQQSSVTTIVK 379
Cdd:pfam14703  81 GFLGLF--GKKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAA-------------AAQINPQLMH 145
                         170
                  ....*....|....*....
gi 1196702590 380 SHHWRVAQAPHPKDIIWKH 398
Cdd:pfam14703 146 PKGWTVELAPEPRDVIWEN 164
RSN1_TM super family cl16507
Late exocytosis, associated with Golgi transport; This family represents the first three ...
40-197 2.06e-13

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


The actual alignment was detected with superfamily member pfam13967:

Pssm-ID: 433613  Cd Length: 158  Bit Score: 68.76  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  40 TVLFLNIVLWVFVLLLYSFLRK--AAWDYGRLallihndsltslIYGEQSEKSSPSeislemerRDKGFCSWFFNSLTMK 117
Cdd:pfam13967   4 TSLVINLVIALVFLLLFSILRPknKRVYAPRT------------YLAPEEERTPPL--------PGTGLFGWIPPLLKIP 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 118 DQDLISKCGDDARIYLTFQYHFIIYVLILCVPSLGIILPINYTGTVLDRNSH------FGRTTIVNVSTESKLLWVHSLF 191
Cdd:pfam13967  64 DEEILQHAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDsltrtgLDKLSSSNNVEGSNRLWAHVVV 143

                  ....*.
gi 1196702590 192 AFLYFL 197
Cdd:pfam13967 144 AYIFTG 149
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
427-681 4.06e-56

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 193.89  E-value: 4.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 427 PAIIINTIDMYNVTRPIEKLQSP----------VVTQFFPSLLLWAFTVIMPLMVYFSAFLEAHWTRSSQNLIIVHKCYI 496
Cdd:pfam02714  19 PVAFVGLLSNLETLTKVWPFLKWilelppkllgLVTGLLPPLLLSLLMALLPIILRFLSKLQGAPSRSDIELSVQSKYFA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 497 FLVFMVVILPSMGLTSLDVFLrwlfDIYYLEQATIRFQCVFLPDNGAFFINYVITAALLGTGMELMRLGSLFMYSTRLFF 576
Cdd:pfam02714  99 FLVVNVFLVFTLASSASSLIE----QIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQLGPLILFYIKRKF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 577 SRSEPERVHIRKNQAIEFQYGREYAWMMNVFTVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSYAPTKLSEQIHMaa 656
Cdd:pfam02714 175 LDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVYVTKYESGGRFW-- 252
                         250       260
                  ....*....|....*....|....*
gi 1196702590 657 vsqaIFAPLLGLFWMLFFSILRAGY 681
Cdd:pfam02714 253 ----PRALNRLLVGLYLFQLCLIGL 273
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
220-398 5.45e-49

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 170.20  E-value: 5.45e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 220 RTLMITYVPTDIQDPEMVIKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGRVmIRIHPCARL 299
Cdd:pfam14703   2 RTVLVTGIPKDLRSEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK-PKKRPTHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 300 CFCKCWtcFKEVDAEQYYSELEEQLTDEFNAELNRVRLKRLDLIFVTFQDSRMAQRVqedykyihcgvhpQQSSVTTIVK 379
Cdd:pfam14703  81 GFLGLF--GKKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAA-------------AAQINPQLMH 145
                         170
                  ....*....|....*....
gi 1196702590 380 SHHWRVAQAPHPKDIIWKH 398
Cdd:pfam14703 146 PKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
15-688 1.89e-32

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 135.24  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  15 LNMTVDECFQSRNTVLQGQPFGGIPTVLFLNIVLWVFVLLLYSFLRK-AAWDYgrlallihndSLTSLIYGEQSEKSSPS 93
Cdd:COG5594     1 MVDSKSDLFVNGAKPPLNRSTSAVITQLVFAGLIFLVFLILFLILRKrWKRLY----------APRTNFDGQNECLPEPN 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  94 EislemerrdKGFCSWFFNSLTMKDQDLISKCGDDARIYLTFQYHFIIYVLILCVPSLGIILPINYTGT-----VLDRNS 168
Cdd:COG5594    71 P---------SSYWGWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQkatngNSDSES 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 169 HFGRTTIVNVsTESKLLWVHS--------LFAFLYFLT-NFVLMAHHRLGFVP--------KKSQKVTRTLMITYVPTDI 231
Cdd:COG5594   142 GLDKLSISNV-SPSNRLYAHVflswfffgYVLFIIFRElRFYVVLRQAYLRSPlyqqslltLQNNLSSRTVLISGLPSEL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 232 QDPEmvikHFHEAYPGCVVTRVHFCYDVRNLIDLDDQ--------RRHAMRGRLYYTAKAKKTG---------------- 287
Cdd:COG5594   221 RSDE----ELKELFDKLKVGEIDSDVLCRDLGTLQELykerdkilKKLEKALNELLNKLLKKSHlktnkksgkltpsrkk 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 288 -------------RVMIRIHPCARLCFCKcwtcfkEVDAEQYYSEleeQLTdEFNAELNRVR-----LKRLDLIFVTFQD 349
Cdd:COG5594   297 efeilpeyvpdkkRPKHRIKKLNKGIFGK------KVDAIDYYSA---KLT-KLDAEIENARkslyeNTPTKSGFITFKS 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 350 SRMAQRVQEdykyIHCGVHPQQSSVTTIvkshhwrvaqAPHPKDIIWKHLSIrrfSWWARF---IAINTFLFFLFVFLTT 426
Cdd:COG5594   367 QASAQIAAQ----SQIYSRVLGKLKVEI----------APAPNDIIWDNLRL---SRKERLfkrISANILFILLIILWAF 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 427 P----AIIINtidMYNVTRPIEKLQS---------PVVTQFFPSLLLWAFTVIMPLMVYFSAFLEAHWTRSSQNLIIVHK 493
Cdd:COG5594   430 PvafvGTISN---LNTLSSLWPFLKFilkdppflaGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNK 506
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 494 CYIFLV---FMVVILPSMGLTSLDVFLRWLFDIYYLEQATirfqcvfLPDNGAFFINYVITAALLGTGMELMRLGSLFMY 570
Cdd:COG5594   507 YFAFLFvnlFLVVTLASSFSSIVWSLLKEPTSIMTLLANN-------LPKASNFFISYIILQGLSGFPGTLLQIVPLLLS 579
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 571 STRLFFSRSEPERVHIRKNQAIEFQYGREYAWMMNVFTVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSY-APTKLS 649
Cdd:COG5594   580 LVLGKFKDSTPRQKWNRLETPPSFQFGTVLPQPILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVSnHSPESG 659
                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 1196702590 650 EQIHMAAVSQAIFAPLLGLFWMLFFSILRAGYLHSITLF 688
Cdd:COG5594   660 GGYWPRALFQIIVGLYLFQVCLLGLFSLAKGWGLSVLLF 698
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
40-197 2.06e-13

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 68.76  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  40 TVLFLNIVLWVFVLLLYSFLRK--AAWDYGRLallihndsltslIYGEQSEKSSPSeislemerRDKGFCSWFFNSLTMK 117
Cdd:pfam13967   4 TSLVINLVIALVFLLLFSILRPknKRVYAPRT------------YLAPEEERTPPL--------PGTGLFGWIPPLLKIP 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 118 DQDLISKCGDDARIYLTFQYHFIIYVLILCVPSLGIILPINYTGTVLDRNSH------FGRTTIVNVSTESKLLWVHSLF 191
Cdd:pfam13967  64 DEEILQHAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDsltrtgLDKLSSSNNVEGSNRLWAHVVV 143

                  ....*.
gi 1196702590 192 AFLYFL 197
Cdd:pfam13967 144 AYIFTG 149
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
427-681 4.06e-56

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 193.89  E-value: 4.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 427 PAIIINTIDMYNVTRPIEKLQSP----------VVTQFFPSLLLWAFTVIMPLMVYFSAFLEAHWTRSSQNLIIVHKCYI 496
Cdd:pfam02714  19 PVAFVGLLSNLETLTKVWPFLKWilelppkllgLVTGLLPPLLLSLLMALLPIILRFLSKLQGAPSRSDIELSVQSKYFA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 497 FLVFMVVILPSMGLTSLDVFLrwlfDIYYLEQATIRFQCVFLPDNGAFFINYVITAALLGTGMELMRLGSLFMYSTRLFF 576
Cdd:pfam02714  99 FLVVNVFLVFTLASSASSLIE----QIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQLGPLILFYIKRKF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 577 SRSEPERVHIRKNQAIEFQYGREYAWMMNVFTVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSYAPTKLSEQIHMaa 656
Cdd:pfam02714 175 LDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVYVTKYESGGRFW-- 252
                         250       260
                  ....*....|....*....|....*
gi 1196702590 657 vsqaIFAPLLGLFWMLFFSILRAGY 681
Cdd:pfam02714 253 ----PRALNRLLVGLYLFQLCLIGL 273
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
220-398 5.45e-49

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 170.20  E-value: 5.45e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 220 RTLMITYVPTDIQDPEMVIKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGRVmIRIHPCARL 299
Cdd:pfam14703   2 RTVLVTGIPKDLRSEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK-PKKRPTHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 300 CFCKCWtcFKEVDAEQYYSELEEQLTDEFNAELNRVRLKRLDLIFVTFQDSRMAQRVqedykyihcgvhpQQSSVTTIVK 379
Cdd:pfam14703  81 GFLGLF--GKKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAA-------------AAQINPQLMH 145
                         170
                  ....*....|....*....
gi 1196702590 380 SHHWRVAQAPHPKDIIWKH 398
Cdd:pfam14703 146 PKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
15-688 1.89e-32

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 135.24  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  15 LNMTVDECFQSRNTVLQGQPFGGIPTVLFLNIVLWVFVLLLYSFLRK-AAWDYgrlallihndSLTSLIYGEQSEKSSPS 93
Cdd:COG5594     1 MVDSKSDLFVNGAKPPLNRSTSAVITQLVFAGLIFLVFLILFLILRKrWKRLY----------APRTNFDGQNECLPEPN 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  94 EislemerrdKGFCSWFFNSLTMKDQDLISKCGDDARIYLTFQYHFIIYVLILCVPSLGIILPINYTGT-----VLDRNS 168
Cdd:COG5594    71 P---------SSYWGWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQkatngNSDSES 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 169 HFGRTTIVNVsTESKLLWVHS--------LFAFLYFLT-NFVLMAHHRLGFVP--------KKSQKVTRTLMITYVPTDI 231
Cdd:COG5594   142 GLDKLSISNV-SPSNRLYAHVflswfffgYVLFIIFRElRFYVVLRQAYLRSPlyqqslltLQNNLSSRTVLISGLPSEL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 232 QDPEmvikHFHEAYPGCVVTRVHFCYDVRNLIDLDDQ--------RRHAMRGRLYYTAKAKKTG---------------- 287
Cdd:COG5594   221 RSDE----ELKELFDKLKVGEIDSDVLCRDLGTLQELykerdkilKKLEKALNELLNKLLKKSHlktnkksgkltpsrkk 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 288 -------------RVMIRIHPCARLCFCKcwtcfkEVDAEQYYSEleeQLTdEFNAELNRVR-----LKRLDLIFVTFQD 349
Cdd:COG5594   297 efeilpeyvpdkkRPKHRIKKLNKGIFGK------KVDAIDYYSA---KLT-KLDAEIENARkslyeNTPTKSGFITFKS 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 350 SRMAQRVQEdykyIHCGVHPQQSSVTTIvkshhwrvaqAPHPKDIIWKHLSIrrfSWWARF---IAINTFLFFLFVFLTT 426
Cdd:COG5594   367 QASAQIAAQ----SQIYSRVLGKLKVEI----------APAPNDIIWDNLRL---SRKERLfkrISANILFILLIILWAF 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 427 P----AIIINtidMYNVTRPIEKLQS---------PVVTQFFPSLLLWAFTVIMPLMVYFSAFLEAHWTRSSQNLIIVHK 493
Cdd:COG5594   430 PvafvGTISN---LNTLSSLWPFLKFilkdppflaGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNK 506
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 494 CYIFLV---FMVVILPSMGLTSLDVFLRWLFDIYYLEQATirfqcvfLPDNGAFFINYVITAALLGTGMELMRLGSLFMY 570
Cdd:COG5594   507 YFAFLFvnlFLVVTLASSFSSIVWSLLKEPTSIMTLLANN-------LPKASNFFISYIILQGLSGFPGTLLQIVPLLLS 579
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 571 STRLFFSRSEPERVHIRKNQAIEFQYGREYAWMMNVFTVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSY-APTKLS 649
Cdd:COG5594   580 LVLGKFKDSTPRQKWNRLETPPSFQFGTVLPQPILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVSnHSPESG 659
                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 1196702590 650 EQIHMAAVSQAIFAPLLGLFWMLFFSILRAGYLHSITLF 688
Cdd:COG5594   660 GGYWPRALFQIIVGLYLFQVCLLGLFSLAKGWGLSVLLF 698
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
40-197 2.06e-13

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 68.76  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590  40 TVLFLNIVLWVFVLLLYSFLRK--AAWDYGRLallihndsltslIYGEQSEKSSPSeislemerRDKGFCSWFFNSLTMK 117
Cdd:pfam13967   4 TSLVINLVIALVFLLLFSILRPknKRVYAPRT------------YLAPEEERTPPL--------PGTGLFGWIPPLLKIP 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1196702590 118 DQDLISKCGDDARIYLTFQYHFIIYVLILCVPSLGIILPINYTGTVLDRNSH------FGRTTIVNVSTESKLLWVHSLF 191
Cdd:pfam13967  64 DEEILQHAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDsltrtgLDKLSSSNNVEGSNRLWAHVVV 143

                  ....*.
gi 1196702590 192 AFLYFL 197
Cdd:pfam13967 144 AYIFTG 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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