NCBI Conserved Domain Search

Conserved domains on [gi|1195674356|ref|XP_021030538|]

View

olfactory receptor 6C1-like [Mus caroli]

Protein Classification

olfactory receptor( domain architecture ID 11610373)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

23-287

1.85e-134

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 381.83 E-value: 1.85e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRvclqlVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

23-287

1.85e-134

Pssm-ID: 320578 Cd Length: 270 Bit Score: 381.83 E-value: 1.85e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRvclqlVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-297

8.89e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 145.72 E-value: 8.89e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  33 YTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYL 112
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 113 LAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDTKF 187
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISriglgVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 188 LEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRAS--LTK 265
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPplLQI 244

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195674356 266 GVAILNTSVATMLNPFIYSLRNQQVKQAFMNM 297
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

18-154

7.77e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 37.45 E-value: 7.77e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  18 DPKLQVVILVFLFITYTLSITGNLTIITLtLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIIsgdKIISFNDCI- 96
Cdd:PHA03087   36 YDTNSTILIVVYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYIL---FQWSFGEFAc 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195674356  97 ---AQLFFLNLFGEIEFylLAAMSYDRYIAICKPLHYL---TIMSQKVFTC--WLVSFLVIFPALM 154
Cdd:PHA03087  112 kivSGLYYIGFYNSMNF--ITVMSVDRYIAIVHPVKSNkinTVKYGYIVSLviWIISIIETTPILF 175

Name

Accession

Description

Interval

E-value

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

23-287

1.85e-134

Pssm-ID: 320578 Cd Length: 270 Bit Score: 381.83 E-value: 1.85e-134

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRvclqlVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-287

3.68e-116

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 335.61 E-value: 3.68e-116

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd13954     5 VLFLLI-YLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd13954    84 GGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVcillaAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd13954   164 SCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd13954   244 SDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-294

1.27e-100

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 296.29 E-value: 1.27e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15225     5 VVFLLI-YLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15225    84 GGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLqlvagSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd15225   164 ACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15225   244 PETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-287

2.76e-99

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 292.85 E-value: 2.76e-99

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15911     5 LLFLVI-YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMS-----QKVFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15911    84 AATECYLLAVMSYDRYLAICKPLHYASLMNgrlclQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd15911   164 SCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15911   244 RDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-287

2.76e-96

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 285.17 E-value: 2.76e-96

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15230     5 VLFLLI-YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15230    84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRvciqlVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd15230   164 SCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYS 243

                         250       260
                  ....*....|....*....|....*..
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15230   244 LDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

26-294

1.01e-94

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 281.42 E-value: 1.01e-94

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15235     6 LLFLAM-YLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15235    85 GNTDSFLLAVMAYDRYVAICHPLHYATVMSPKrclllVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd15235   165 SCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYS 244

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15235   245 ADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-291

2.36e-90

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 270.73 E-value: 2.36e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  10 FILLGLSDDPKLQVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKI 89
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  90 ISFNDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGS 164
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVslvagSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 165 NIIDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISIS 244
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195674356 245 YGSCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVK 291
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

9-293

6.51e-87

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 262.30 E-value: 6.51e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356   9 EFILLGLSDDPKLQVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDK 88
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  89 IISFNDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTC-----WLVSFLVIFPALMLVLHLDYCG 163
Cdd:cd15943    81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQlvagsYLIGFVNALIQTICTFRLPFCG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 164 SNIIDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISI 243
Cdd:cd15943   161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195674356 244 SYGSCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15943   241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDA 290

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-294

3.10e-86

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 259.84 E-value: 3.10e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15229     5 LVFLVI-YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15229    84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVqlvggAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTkFLEKMGFFCAVFIVLF-TLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAAD 259
Cdd:cd15229   164 SCSDT-FANKMVLLTSSVIFGLgSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195674356 260 RASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15229   243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

23-294

6.42e-85

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 256.47 E-value: 6.42e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15419     2 LLFLLFLVI-YMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTcWLVSFLVIFPALMLVLH------LDYCGSNIIDHFACDYFP 176
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCV-QLVAGSYLCGCINSIIQtsftfsLSFCGSNEIDHFFCDVPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 177 LLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS 256
Cdd:cd15419   160 LLKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPG 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15419   240 AVSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

23-294

7.15e-85

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 256.42 E-value: 7.15e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15231     2 LLFLIFLII-YLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15231    81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVclqlaAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15231   161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15231   241 GYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-294

1.38e-84

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 256.05 E-value: 1.38e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  10 FILLGLSDDPKLQVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKI 89
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  90 ISFNDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGS 164
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKlcvllVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 165 NIIDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISIS 244
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195674356 245 YGSCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15410   241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDAL 290

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

23-287

2.75e-84

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 254.69 E-value: 2.75e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15227     2 LHFVLFLLI-YLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMS-----QKVFTCWLVSFlvifpaLMLVLH------LDYCGSNIIDHFA 171
Cdd:cd15227    81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNrgacvQMAAASWLSGL------LYGALHtantfsLPFCGSNVIHQFF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 172 CDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFM 251
Cdd:cd15227   155 CDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFA 234

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 252 YIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15227   235 YLKPPSDSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-294

2.83e-84

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 254.87 E-value: 2.83e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15417     5 VLFLGI-YLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMS-----QKVFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15417    84 GLTECFLLAAMAYDRYVAICNPLLYSVIMSprlcvQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd15417   164 SCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15417   244 QDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDAL 277

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

27-287

4.52e-84

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 254.08 E-value: 4.52e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  27 VFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFG 106
Cdd:cd15918     6 LFLGM-YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 107 EIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLS 181
Cdd:cd15918    85 DLDNFLLAVMAYDRYVAICHPLHYTTIMSPRlcillVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 182 CSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRA 261
Cdd:cd15918   165 CSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSA 244

                         250       260
                  ....*....|....*....|....*.
gi 1195674356 262 SLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15918   245 SKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

24-287

8.52e-83

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 250.66 E-value: 8.52e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15237     2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15237    82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVcvrlaATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAA 258
Cdd:cd15237   162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                         250       260
                  ....*....|....*....|....*....
gi 1195674356 259 DRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15237   242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

23-287

8.41e-82

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 248.35 E-value: 8.41e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15224     1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15224    81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVqlaagSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15224   161 LNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15224   241 ISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

24-294

3.82e-81

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 246.69 E-value: 3.82e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15421    82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVcllmaAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAA 258
Cdd:cd15421   162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 259 DRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15421   242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-297

3.70e-79

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 242.27 E-value: 3.70e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  14 GLSDDPKLQV-VILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISF 92
Cdd:cd15406     1 GLTDQPELQLpLFLLFLGI-YVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  93 NDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVfTCWLVSFLVIFPALMLVLH------LDYCGSNI 166
Cdd:cd15406    80 PECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRV-CSLLVAGVYIMGLIGATVHtscmlrLSFCGDNV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 167 IDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYG 246
Cdd:cd15406   159 INHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYG 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195674356 247 SCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAFMNM 297
Cdd:cd15406   239 SIIFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

26-294

5.46e-79

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 241.46 E-value: 5.46e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15413     5 GLFLVI-YLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVftCW-------LVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15413    84 IISELFLLSAMAYDRYVAICNPLLYTVIMSQRV--CIvlvaipyLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAA 258
Cdd:cd15413   162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 259 DRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15413   242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDAL 277

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

23-287

2.82e-78

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 239.05 E-value: 2.82e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15431     1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLV-IFPALMLVLHLdyCGSNIIDHFACDYFP 176
Cdd:cd15431    81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVciqlaAGSWVSAFLLtVIPVLTMPLHF--CGPNVINHFFCEVQA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 177 LLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS 256
Cdd:cd15431   159 LLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQ 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15431   239 SKSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

24-287

1.14e-77

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 237.52 E-value: 1.14e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15947     2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15947    82 WLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRlcvqlAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAA 258
Cdd:cd15947   162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195674356 259 DRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15947   242 YSQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

23-294

1.36e-77

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 237.99 E-value: 1.36e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15411     2 PLFVLFLVI-YVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLklaagSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-287

2.19e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 237.16 E-value: 2.19e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTC-----WLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGlatgvWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

23-294

3.69e-77

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 236.84 E-value: 3.69e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15420     1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15420    81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVcttlaATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15420   161 LKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15420   241 SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

25-294

4.59e-77

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 236.53 E-value: 4.59e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQ 179
Cdd:cd15429    83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLciqlaAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAAD 259
Cdd:cd15429   163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195674356 260 RASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15429   243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-296

8.04e-77

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 235.78 E-value: 8.04e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15407     5 IIFTLI-YLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15407    84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVcacltIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR 260
Cdd:cd15407   164 SCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 261 ASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAFMN 296
Cdd:cd15407   244 MDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

23-293

5.48e-76

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 233.81 E-value: 5.48e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15434     1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMS-----QKVFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15434    81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHprlcwKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15434   161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15434   241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGA 276

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

23-287

9.56e-76

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 232.65 E-value: 9.56e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15914     1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15914    81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTqlaagCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15914   161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15914   241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

23-294

1.14e-73

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 227.68 E-value: 1.14e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15409     1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15409    81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVqlitaSYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15409   161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15409   241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

23-287

1.53e-73

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 227.20 E-value: 1.53e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15913     1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15913    81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQlcgklVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15913   161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15913   241 GNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-294

6.07e-73

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 226.59 E-value: 6.07e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  10 FILLGLSDDPKLQVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKI 89
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  90 ISFNDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGS 164
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVclqlmAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 165 NIIDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISIS 244
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195674356 245 YGSCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAF 290

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

24-287

7.65e-73

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 225.26 E-value: 7.65e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15915     2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15915    82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVclllaVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIP-SASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15915   162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15915   242 GDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

23-293

8.78e-73

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 225.44 E-value: 8.78e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15233     2 VLFVTFLLA-YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15233    81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTalvgiSCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15233   161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15233   241 VYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-293

6.79e-72

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 223.85 E-value: 6.79e-72

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  10 FILLGLSDDPKLQVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKI 89
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  90 ISFNDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTCWLVS--FLVIFPALM---LVLHLDYCGS 164
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGayLSGMATSLVhttLTFRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 165 NIIDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISIS 244
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195674356 245 YGSCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEA 289

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

27-294

1.35e-71

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 222.45 E-value: 1.35e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  27 VFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFG 106
Cdd:cd15234     6 LFLSM-YLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 107 EIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLS 181
Cdd:cd15234    85 GLDNFLLAVMAYDRYVAICHPLHYTVIMNPClcgllVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 182 CSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRA 261
Cdd:cd15234   165 CSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSS 244

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195674356 262 SLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15234   245 RKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-287

8.23e-71

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 220.16 E-value: 8.23e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRvcgllVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTiLKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 AdrASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15939   240 T--FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

23-296

1.02e-70

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 220.35 E-value: 1.02e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTCwLVSFLVIFPAL------MLVLHLDYCGSNIIDHFACDYFP 176
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCIS-LVTFPYIYGFLngliqtILTFRLSFCGSNVINHFYCADPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 177 LLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS 256
Cdd:cd15412   160 LIKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPP 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAFMN 296
Cdd:cd15412   240 SEESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-294

4.28e-70

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 218.88 E-value: 4.28e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  22 QVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFF 101
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 102 LNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFP 176
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKlcmglVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 177 LLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS 256
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15418   241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEAL 278

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

24-295

7.30e-70

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 218.00 E-value: 7.30e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLF-ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15416     1 IILFVLFlVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVfTCWLV------SFLVIFPALMLVLHLDYCGSNIIDHFACDYFP 176
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKV-CVLLVaasylgGCLNALVFTTCVFSLSFCGPNEINHFFCDFPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 177 LLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS 256
Cdd:cd15416   160 LLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPN 239

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAFM 295
Cdd:cd15416   240 SSYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-293

3.02e-69

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 216.51 E-value: 3.02e-69

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFI-TYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd15405     3 LFFLFLgIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-FTCWLVSFLVIFPALML----VLHLDYCGSNIIDHFACDYFPLLQ 179
Cdd:cd15405    83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVcSLLMLGSYVMGFAGAMAhtgcMLRLTFCDSNIINHYMCDILPLLQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAAD 259
Cdd:cd15405   163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 260 RASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15405   243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLA 276

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-287

1.17e-68

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 214.54 E-value: 1.17e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15430     1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVF-----TCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15430    81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCvqmaaGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15430   161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15430   241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

23-293

1.39e-68

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 214.65 E-value: 1.39e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15428     1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15428    81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVcislaTGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15428   161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15428   241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHA 276

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

24-287

1.44e-68

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 214.37 E-value: 1.44e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15226     2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15226    82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRmcillVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASqRSKAFSTCSSPMIVISISYGSCIFMYIKSSAa 258
Cdd:cd15226   162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGG-SSKALSTCSAHITVVVLFFGPCIFIYVWPFS- 239

                         250       260
                  ....*....|....*....|....*....
gi 1195674356 259 dRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15226   240 -TFPVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

23-300

2.36e-68

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 214.60 E-value: 2.36e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVftcwlVSFLVIFPALMLVLH----------LDYCGSNIIDHFAC 172
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRV-----CVQLVVGPYVVGLLNttthttaaffLPFCGPNVINHFFC 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 173 DYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMY 252
Cdd:cd15414   156 DIPPLLSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIY 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1195674356 253 IKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAFMNMARK 300
Cdd:cd15414   236 VRPSSSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

23-293

8.23e-68

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 212.67 E-value: 8.23e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15424     1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMS-----QKVFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15424    81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGrwrqlQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15424   161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15424   241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGA 276

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

24-287

6.29e-67

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 210.27 E-value: 6.29e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15936     2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15936    82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTglvagSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTIlKIPSASQRSKAFSTCSSPMIVISISYGSCIFMY---IKS 255
Cdd:cd15936   162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYarpFQT 240

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195674356 256 SAADRAsltkgVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15936   241 FPMDKA-----VSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

24-294

1.45e-66

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 209.60 E-value: 1.45e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFIT-YTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15228     1 TILFVLFLAfYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTC-----WLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15228    81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALlaagtWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15228   161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 AdrASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15228   241 S--PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

24-287

4.42e-66

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 208.06 E-value: 4.42e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLF-ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15940     1 LAFFMLFlVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15940    81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKvclwlVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIpSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15940   161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 AdrASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15940   240 S--FSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

22-294

5.45e-66

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 208.04 E-value: 5.45e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  22 QVVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFF 101
Cdd:cd15415     1 VPLFMLFLLI-YFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 102 LNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTC-----WLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFP 176
Cdd:cd15415    80 FAVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQlvagsYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 177 LLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS 256
Cdd:cd15415   160 LLKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPS 239

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15415   240 SQYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDAL 277

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-293

8.81e-66

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 207.69 E-value: 8.81e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIIS-GDKIISFNDCIAQLFFLNL 104
Cdd:cd15916     5 LIFLII-YLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYFFHF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQ 179
Cdd:cd15916    84 LGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTrlatgTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAAD 259
Cdd:cd15916   164 LACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKE 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 260 raSLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15916   244 --ALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTA 275

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

23-294

2.33e-65

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 206.56 E-value: 2.33e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRlcqqlAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

33-293

2.25e-62

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 198.84 E-value: 2.25e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  33 YTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYL 112
Cdd:cd15236    11 YLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 113 LAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDTKF 187
Cdd:cd15236    91 LAVMAYDRYVAICHPLHYTAIMRPElcvllVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 188 LEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRASLTKGV 267
Cdd:cd15236   171 NELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVA 250

                         250       260
                  ....*....|....*....|....*.
gi 1195674356 268 AILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15236   251 SVMYTVVTPMLNPFIYSLRNRDIKGA 276

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

25-293

6.85e-61

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 194.96 E-value: 6.85e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd15942     3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTC-----WLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQ 179
Cdd:cd15942    83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLClslgtWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAAD 259
Cdd:cd15942   163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 260 raSLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15942   243 --PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDA 274

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

23-287

3.00e-57

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 185.37 E-value: 3.00e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15946     2 ILFAVFLLI-YLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMS-----QKVFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15946    81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSwglciLMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15946   161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 ADRASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15946   241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

25-290

1.85e-54

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 178.25 E-value: 1.85e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd15917     3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQ 179
Cdd:cd15917    83 FTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGkiglaILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSS-AA 258
Cdd:cd15917   163 LACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRfGH 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195674356 259 DRASLTKG-VAILNTSVATMLNPFIYSLRNQQV 290
Cdd:cd15917   243 HVPPHVHIlLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

23-287

1.05e-53

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 176.22 E-value: 1.05e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15938     1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15938    81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRlcwvlVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIirtILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15938   161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFS 237

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195674356 258 AdrASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15938   238 T--FPVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

24-293

6.52e-53

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 174.59 E-value: 6.52e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15433     2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15433    82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLcqtlaSISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAA 258
Cdd:cd15433   162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195674356 259 DRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQA 293
Cdd:cd15433   242 YSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGA 276

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

29-294

5.87e-52

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 172.09 E-value: 5.87e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  29 LFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEI 108
Cdd:cd15223     7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 109 EFYLLAAMSYDRYIAICKPLHYLTIMSQKVFTCWLVSFLV-----IFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCS 183
Cdd:cd15223    87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIrsgllVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 184 DTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRAS- 262
Cdd:cd15223   167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPp 246

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195674356 263 -LTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15223   247 dVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

25-294

6.51e-52

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 171.96 E-value: 6.51e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFLFItYTLSITGNLTIITLTLLDSHLQT-PMYFFLRNFSVLEVPFTTVTILKFLGSIISGD-KIISFNDCIAQLFFL 102
Cdd:cd15941     4 FLLFLLI-YLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPL 177
Cdd:cd15941    83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAglaggTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 178 LQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15941   163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195674356 258 ADRASltKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15941   243 SQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

33-287

8.70e-52

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 171.49 E-value: 8.70e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  33 YTLSITGNLTIITLTLLDSHL-QTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEFY 111
Cdd:cd15935    11 YAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 112 LLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDTK 186
Cdd:cd15935    91 LLTLMAYDRYVAICHPLRYLAVMNRQlciklLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 187 FLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTiLKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAadRASLTKG 266
Cdd:cd15935   171 VVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS--SSSVDKV 247

                         250       260
                  ....*....|....*....|.
gi 1195674356 267 VAILNTSVATMLNPFIYSLRN 287
Cdd:cd15935   248 ASVFYTLITPALNPLIYTLRN 268

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

33-290

1.53e-48

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 162.97 E-value: 1.53e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  33 YTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYL 112
Cdd:cd15950    11 YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 113 LAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDTKF 187
Cdd:cd15950    91 LLAMAFDRYVAICHPLRYSAILTSQVIAqiglaIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRP 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 188 LEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIF-MYIKSSAADRASLTKG 266
Cdd:cd15950   171 SSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFGQGVPPHTQV 250

                         250       260
                  ....*....|....*....|....*
gi 1195674356 267 -VAILNTSVATMLNPFIYSLRNQQV 290
Cdd:cd15950   251 lLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-287

1.64e-48

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 162.98 E-value: 1.64e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15937     2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLL 178
Cdd:cd15937    82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRvccvlVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 QLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIrTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAA 258
Cdd:cd15937   162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                         250       260
                  ....*....|....*....|....*....
gi 1195674356 259 drASLTKGVAILNTSVATMLNPFIYSLRN 287
Cdd:cd15937   241 --FPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

30-290

5.80e-47

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 159.08 E-value: 5.80e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  30 FITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIE 109
Cdd:cd15952     8 CAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGME 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 110 FYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSD 184
Cdd:cd15952    88 SAVLVAMAFDRYVAICNPLRYTTILTNKVISvialgIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACAS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 185 TKfLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRASLT 264
Cdd:cd15952   168 IR-INIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRY 246

                         250       260
                  ....*....|....*....|....*...
gi 1195674356 265 KG--VAILNTSVATMLNPFIYSLRNQQV 290
Cdd:cd15952   247 IHilLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

30-290

5.43e-46

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 156.68 E-value: 5.43e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  30 FITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIE 109
Cdd:cd15221     8 CSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 110 FYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSD 184
Cdd:cd15221    88 SAILLAMAFDRYVAICYPLRYTTILTHSVigkigVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACAD 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 185 TKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRASLT 264
Cdd:cd15221   168 ITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIPRH 247

                         250       260
                  ....*....|....*....|....*...
gi 1195674356 265 KGVAILNTSVAT--MLNPFIYSLRNQQV 290
Cdd:cd15221   248 VHILLANLYVLVppMLNPIVYGVKTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-290

1.06e-45

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 155.74 E-value: 1.06e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd15222     3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQ 179
Cdd:cd15222    83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRiakigLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSS----------PMIVISIsygscI 249
Cdd:cd15222   163 LACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVShicavlifyvPMIGLSM-----V 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195674356 250 FMYIKSSAADRASLTKGVAILntsVATMLNPFIYSLRNQQV 290
Cdd:cd15222   238 HRFGKHASPLVHVLMANVYLL---VPPVLNPIIYSVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-290

1.91e-44

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 152.42 E-value: 1.91e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  29 LFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEI 108
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 109 EFYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCS 183
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAklglvGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 184 DTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFmyikSSAADRASl 263
Cdd:cd15953   167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALF----SFLTHRFG- 241

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195674356 264 tKGV--------AILNTSVATMLNPFIYSLRNQQV 290
Cdd:cd15953   242 -QGIaphihiilANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

33-291

1.22e-42

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 147.74 E-value: 1.22e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  33 YTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYL 112
Cdd:cd15948    12 FTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 113 LAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDTKF 187
Cdd:cd15948    92 LLAMAFDRYVAICNPLRYATILTNSVITkiglaALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRF 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 188 LEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRASLTKGV 267
Cdd:cd15948   172 NNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHVAPHVHI 251

                         250       260
                  ....*....|....*....|....*.
gi 1195674356 268 AILNTSV--ATMLNPFIYSLRNQQVK 291
Cdd:cd15948   252 LLANFYLlfPPMMNPIVYGVKTKQIR 277

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-290

3.20e-42

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 146.72 E-value: 3.20e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  31 ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEF 110
Cdd:cd15951     9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 111 YLLAAMSYDRYIAICKPLHYLTIMSQKVFTCW-----LVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDT 185
Cdd:cd15951    89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIglavvLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 186 KFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRASLTK 265
Cdd:cd15951   169 RVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPPHV 248

                         250       260
                  ....*....|....*....|....*..
gi 1195674356 266 GVAILNTS--VATMLNPFIYSLRNQQV 290
Cdd:cd15951   249 HILIANVYllVPPMLNPIIYGVRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-297

8.89e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 145.72 E-value: 8.89e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  33 YTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYL 112
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 113 LAAMSYDRYIAICKPLHYLTIMSQKVFT-----CWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSDTKF 187
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISriglgVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 188 LEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRAS--LTK 265
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPplLQI 244

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195674356 266 GVAILNTSVATMLNPFIYSLRNQQVKQAFMNM 297
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

30-290

1.68e-35

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 129.17 E-value: 1.68e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  30 FITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIE 109
Cdd:cd15954     8 CFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGME 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 110 FYLLAAMSYDRYIAICKPLHYLTIMSQKVFT-CWLVSFL----VIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCSD 184
Cdd:cd15954    88 SGVLMLMALDRYVAICYPLRYATILTNPVITkAGLATFLrgvmLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACAN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 185 TKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADR---A 261
Cdd:cd15954   168 IRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGGHhitP 247

                         250       260
                  ....*....|....*....|....*....
gi 1195674356 262 SLTKGVAILNTSVATMLNPFIYSLRNQQV 290
Cdd:cd15954   248 HIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

26-290

4.11e-35

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 128.06 E-value: 4.11e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLF 105
Cdd:cd15956     5 LPFCFI-YVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 106 GEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQL 180
Cdd:cd15956    84 SAMESGVLVAMALDRFVAICNPLHYATILTLEVvakagLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 181 SCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAadR 260
Cdd:cd15956   164 ACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRF--G 241

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195674356 261 ASLTKGVAILNTSVATM----LNPFIYSLRNQQV 290
Cdd:cd15956   242 HSVPSAAHVLLSNLYLLlppaLNPIVYGIRTKQI 275

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-291

1.84e-34

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 126.82 E-value: 1.84e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356   8 TEFILLGLSDDPKLQVVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGD 87
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  88 KIISFNDCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKV-----FTCWLVSFLVIFPALMLVLHLDYC 162
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTvirigLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 163 GSNIIDHFACDYFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVIS 242
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195674356 243 ISY-----GSCIFMYIKSSAADRASLTKGVAILntsVATMLNPFIYSLRNQQVK 291
Cdd:cd15949   242 AFYvpiavSSLIHRFGQNVPPPTHILLANFYLL---IPPMLNPIVYGVRTKQIQ 292

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

30-290

3.01e-32

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 120.64 E-value: 3.01e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  30 FITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNLFGEIE 109
Cdd:cd15955     8 CIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 110 FYLLAAMSYDRYIAICKPLHYLTIMSQKVFTCWLV------SFLVIFPALMLVLHLDYCGSNIIDHFACDYFPLLQLSCS 183
Cdd:cd15955    88 SGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVlvvvraVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAAD 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 184 DTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISISYGSCIFMYIKSSAADRasL 263
Cdd:cd15955   168 DVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHH--V 245

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195674356 264 TKGVAILNTS----VATMLNPFIYSLRNQQV 290
Cdd:cd15955   246 APYVHILLSNlyllVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-283

4.59e-25

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 100.83 E-value: 4.59e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  39 GNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIIS-GDKIISFNDCIAQLFFLNLFGEIEFYLLAAMS 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 118 YDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNiidHFACDYFPLLQLSCsdtkfLEKMG 192
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRrakvlILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 193 FFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRS-------KAFSTCSSPMIVISISYGSCIFMYIKSSAADRASLTK 265
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 1195674356 266 G------VAILNTSVATMLNPFIY 283
Cdd:pfam00001 233 LldkalsVTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

25-287

3.33e-14

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 71.17 E-value: 3.33e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYcgsniidhfacDYFPLLQ 179
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRrakllIALIWLLSLLLALPPLLGWGVYDY-----------GGYCCCC 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILK----------IPSASQRSK--------------AFSTCS 235
Cdd:cd00637   150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssNSSRRRRRRrerkvtktllivvvVFLLCW 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195674356 236 SPMIVISISYGSCIFMYIKSSAADRASLTkgVAILNtsvaTMLNPFIYSLRN 287
Cdd:cd00637   230 LPYFILLLLDVFGPDPSPLPRILYFLALL--LAYLN----SAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

24-294

3.33e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 62.20 E-value: 3.33e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCgsnIIDHFACDYFPll 178
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKralimIAAVWVYSLLISLPPLVGWRDETQP---SVVDCECEFTP-- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 qlscsDTKFLekmgFFCAVFIVLFTLVLVFLSYTYIIRTilkipsASQRSKAFST----------CSSPMIVISISYGSC 248
Cdd:cd14967   156 -----NKIYV----LVSSVISFFIPLLIMIVLYARIFRV------ARRELKAAKTlaiivgafllCWLPFFIIYLVSAFC 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1195674356 249 IFMYIKSSAADrasLTKGVAILNtsvaTMLNPFIYSLRNQQVKQAF 294
Cdd:cd14967   221 PPDCVPPILYA---VFFWLGYLN----SALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

23-294

4.36e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 56.45 E-value: 4.36e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVF----TCWLVSFLVIFPALM----LVLHLDYCgsniidhfacdy 174
Cdd:cd14969    81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALiliaFIWLYGLFWALPPLFgwssYVPEGGGT------------ 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 175 fpllqlSCS---DTKFLEKMGFFCAVFIVLFT--LVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSP---------MIV 240
Cdd:cd14969   149 ------SCSvdwYSKDPNSLSYIVSLFVFCFFlpLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakMVL 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1195674356 241 ISIS--------YG--SCIFMYIKSSAADRASLTkgVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd14969   223 VMIVafliawtpYAvvSLYVSFGGESTIPPLLAT--IPALFAKSSTIYNPIIYVFMNKQFRRAL 284

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

34-294

7.20e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 55.72 E-value: 7.20e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  34 TLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTTVtilkflgsiISGDKIISFNDCIAQLFFLNLFG 106
Cdd:cd14968    12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVadilvgaLAIPLAIL---------ISLGLPTNFHGCLFMACLVLVLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 107 EIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVlhldYCGSNIIDHFACDYFPLLQLS 181
Cdd:cd14968    83 QSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRrawgaIAVCWVLSFLVGLTPMFGW----NNGAPLESGCGEGGIQCLFEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 182 CSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRS--------KAFSTCSSPMIVIsISYGSC----- 248
Cdd:cd14968   159 VIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSrrsrstlqKEVKAAKSLAIIL-FLFALCwlplh 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195674356 249 ---IFMYIKSSAADRASLTKgVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd14968   238 iinCITLFCPECKVPKILTY-IAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

23-213

7.38e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 52.60 E-value: 7.38e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTT---VTILKFLGSIIsgdkiisf 92
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVadllvslFCMPLTLlenVYRPWVFGEVL-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  93 ndCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMlVLHLDYCGSNII 167
Cdd:cd14993    73 --CKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRrariiIVAIWVIAIIIMLPLLV-VYELEEIISSEP 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1195674356 168 dhfacdyFPLLQLSCSDTKF--LEKMGFFCAVFIVLFTLVLVFLSYTY 213
Cdd:cd14993   150 -------GTITIYICTEDWPspELRKAYNVALFVVLYVLPLLIISVAY 190

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

25-128

2.72e-07

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 51.01 E-value: 2.72e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  25 ILVFL-FITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPF-----TTVTILKFLGSIISGDKIisfndCIAQ 98
Cdd:cd15085     2 ILSFLmFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMalcgtTIVTVTNYEGYFYLGDAF-----CIFQ 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1195674356  99 LFFLNLFGEIEFYLLAAMSYDRYIAICKPL 128
Cdd:cd15085    77 GFAVNYFGIVSLWSLTLLAYERYNVVCKPM 106

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

24-294

6.61e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 49.80 E-value: 6.61e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEvpfttvtilkFLGSIISGdkIISFND--------- 94
Cdd:cd15082    15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVAD----------FLVSLTGG--TISFLTnargyfflg 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  95 ---CIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMS----QKVFTCWLVSFLVIFPALMlvLHLDYCGSNII 167
Cdd:cd15082    83 vwaCVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGkhaaLGLLFVWTFSFIWTIPPVL--GWSSYTVSKIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 168 DHFACDYFpllQLSCSDTKFLekMGFFCAVFIvlFTLVLVFLSYTYIIRTILKIPSASQRSK------------------ 229
Cdd:cd15082   161 TTCEPNWY---SGNMHDHTYI--ITFFTTCFI--LPLGVIFVSYGKLLQKLRKVSNTQGRLGnarkperqvtrmvvvmiv 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1195674356 230 AFSTCSSPMIVISISYGSCIFMYIKSSAAdrasltkGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15082   234 AFMVCWTPYAAFSILVTAHPTIHLDPRLA-------AIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

24-294

7.58e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 49.55 E-value: 7.58e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILkfLGSIISGDKIISFNDCIAQLFFLN 103
Cdd:cd15069     2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDY---CGSNIIDHFACDYF 175
Cdd:cd15069    80 VLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKrargvIAVLWVLAFGIGLTPFLGWNKAMSatnNSTNPADHGTNHSC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 176 PLLQLSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYII----------------RTILKIPSASQRSKA-----FSTC 234
Cdd:cd15069   160 CLISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFlvacrqlqrtelmdhsRTTLQREIHAAKSLAiivgiFALC 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 235 SSPMIVIsisygSCIFMYIKSSAADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15069   240 WLPVHIL-----NCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

23-294

2.46e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 48.01 E-value: 2.46e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFS-------VLEVPFTTVtilkflgsiISGDKIISFNDC 95
Cdd:cd15068     1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAaadiavgVLAIPFAIT---------ISTGFCAACHGC 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  96 IAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVifpALMLVLHLDYCGSNIIDHF 170
Cdd:cd15068    72 LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTrakgiIAICWVLSFAI---GLTPMLGWNNCGQPKEGKN 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 171 ACDYFPLLQLSC--SDTKFLEKMGFFCAVFIVLFTLVL-------VFLSYTYIIRTILKIPSASQRSKA----------- 230
Cdd:cd15068   149 HSQGCGEGQVAClfEDVVPMNYMVYFNFFACVLVPLLLmlgvylrIFLAARRQLKQMESQPLPGERARStlqkevhaaks 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195674356 231 -------FSTCSSPMIVIsisygSCIFMYIKssAADRASL-TKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15068   229 laiivglFALCWLPLHII-----NCFTFFCP--DCSHAPLwLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

26-155

1.22e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 45.88 E-value: 1.22e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  26 LVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTIL-----KFLGSIISGDKIisfndCIAQLF 100
Cdd:cd15197     4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLtdiiwRITVEWRAGDFA-----CKVIRY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1195674356 101 FLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQ-KVFTC--WLVSFLVIFPALML 155
Cdd:cd15197    79 LQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQaRVLICvaWILSALFSIPMLII 136

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

23-160

1.62e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 45.62 E-value: 1.62e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTTVTILK---FLGSIIsgdkiisf 92
Cdd:cd15055     1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVadflvglLVMPFSMIRSIEtcwYFGDTF-------- 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195674356  93 ndCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLD 160
Cdd:cd15055    73 --CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRrvkicICLCWFVSALYSSVLLYDNLNQP 143

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

23-294

8.89e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 43.13 E-value: 8.89e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItytLSITGNLTIITLTLLDSHLQ-TPMYFFLRNFSVLE----VPFTTVTILKFLGSIISGDKIIsfndCIA 97
Cdd:cd15104     3 GVILAVLSP---LIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADflvgLAIPGLATDELLSDGENTQKVL----CLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  98 QLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVfTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFA-CDYF- 175
Cdd:cd15104    76 RMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKS-AGALIAGLWLYSGLIGFLPLISPQFQQTSYKGkCSFFa 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 176 -----PLLQLSCsdtkflekMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRS----------KAFSTCSSPMIV 240
Cdd:cd15104   155 afhprVLLVLSC--------MVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQihprrtlsdfKAARTVAVLIGC 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195674356 241 ISISYGSCIFMYIKSSAADRASLT---KGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15104   227 FLLSWLPFQITGLVQALCDECKLYdvlEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

20-151

1.05e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 43.27 E-value: 1.05e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  20 KLQVVILVFLFItytLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVpftTVTILKFLGSIISGdkiISFN----DC 95
Cdd:cd15387     1 KVEVTVLALILF---LALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADL---VVAVFQVLPQLIWD---ITFRfygpDF 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  96 IAQLF-FLNLFGEI-EFYLLAAMSYDRYIAICKPLHYLTIMSQK--VFTCWLVSFLVIFP 151
Cdd:cd15387    72 LCRLVkYLQVVGMFaSTYMLLLMSIDRCLAICQPLRSLHRRSDRvyVLFSWLLSLVFSIP 131

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

23-218

2.54e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 41.93 E-value: 2.54e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15083     1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMS--QKVFTC---WLVSFLVIFPALMlvlhldYCGSNIIDHFAC----D 173
Cdd:cd15083    81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRIShrRALIVIavvWLYSLLWVLPPLF------GWSRYVLEGLLTscsfD 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1195674356 174 YfpllqLSCSDTKFLEKMGFFCAVFivLFTLVLVFLSYTYIIRTI 218
Cdd:cd15083   155 Y-----LSRDDANRSYVICLLIFGF--VLPLLIIIYCYSFIFRAV 192

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-294

2.76e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 41.92 E-value: 2.76e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTV------TILKFLGSIISGdkiisFNDCIA 97
Cdd:cd15337     2 LIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVngfplkTISSFNKKWIWG-----KVACEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  98 QLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVfTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFAC----D 173
Cdd:cd15337    77 YGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKR-AFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTsctfD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 174 YFPLLQLSCSDTKFLEKMGFFCAVFIVLFTLVL----VFLSYTYIIRTILKIPSASQRSKA------FSTCSSPMIVIS- 242
Cdd:cd15337   156 YLSRDLNNRLFILGLFIFGFLCPLLIIIFCYVNiiraVRNHEKEMTQTAKSGMGKDTEKNDarkkaeIRIAKVAIILISl 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195674356 243 --ISYGSCIFMYIKSSAADRASLTKGVAILNTSVA---TMLNPFIYSLRNQQVKQAF 294
Cdd:cd15337   236 flLSWTPYAVVALLGQFGPAYWITPYVSELPVMFAkasAIYNPIIYALSHPKFRAAL 292

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

20-220

3.33e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 41.45 E-value: 3.33e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  20 KLQVVILVFLFItytLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTIL---------KFLGSIISGdKII 90
Cdd:cd15196     1 KVEIAVLATILV---LALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLpqliwdityRFYGGDLLC-RLV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  91 SFndciAQLFFLNLfgeiEFYLLAAMSYDRYIAICKPLHYLTIMSQK----VFTCWLVSFLVIFPALMLVlHLDYCGSNI 166
Cdd:cd15196    77 KY----LQVVGMYA----SSYVLVATAIDRYIAICHPLSSHRWTSRRvhlmVAIAWVLSLLLSIPQLFIF-SYQEVGSGV 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195674356 167 IDHFACDYFPLlqlscsdTKFLEKMGFFCAVFIVLFtLVLVFLsYTYIIRTILK 220
Cdd:cd15196   148 YDCWATFEPPW-------GLRAYITWFTVAVFVVPL-IILAFC-YGRICYVVWR 192

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-229

4.30e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 41.28 E-value: 4.30e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  29 LFITYTL----SITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFLNL 104
Cdd:cd15012     2 FIILYTLvfccCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 105 FGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHFAcdyfpllq 179
Cdd:cd15012    82 SYTASIGILVVISVERYIAILHPLRCKQLLTAArlrvtIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEE-------- 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1195674356 180 LSCSDTKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSK 229
Cdd:cd15012   154 ICVLDREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEAR 203

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

23-153

5.83e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 40.92 E-value: 5.83e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15075     1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK----VFTCWLVSFLVIFPAL 153
Cdd:cd15075    81 AFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHalagIASSWLWSLIWNTPPL 135

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

31-294

6.89e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 40.69 E-value: 6.89e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  31 ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTTVTILKFLGSIISGDKiisfndCIAQLFFLN 103
Cdd:cd15304     9 IVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIadmllgfLVMPVSMLTILYGYRWPLPSKL------CAVWIYLDV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQ-----KVFTCWLVSFLVIFPALMLVLHLDycgSNIIDHFACdyfpll 178
Cdd:cd15304    83 LFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRtkaflKIIAVWTISVGISMPIPVFGLQDD---SKVFKEGSC------ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 179 qlSCSDTKFLeKMGFFCAVFIVLFTLVlvfLSYTYIIRTILKIPSASQR-SKAFSTCSSPMIVISISYGSCIFMYIKSSA 257
Cdd:cd15304   154 --LLADENFV-LIGSFVAFFIPLTIMV---ITYFLTIKSLQQSISNEQKaSKVLGIVFFLFVVMWCPFFITNVMAVICKE 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1195674356 258 ADRASLTKGvaILNTSV-----ATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15304   228 SCNEVVIGG--LLNVFVwigylSSAVNPLVYTLFNKTYRSAF 267

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

24-158

8.99e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 40.41 E-value: 8.99e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNF-------SVLEVPFTTVTILkfLGSIISGDKIisfndCI 96
Cdd:cd15065     1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLavadllvALLVMTFAVVNDL--LGYWLFGETF-----CN 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1195674356  97 AQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVF-----TCWLVSFLVIFPALMLVLH 158
Cdd:cd15065    74 IWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRAlvviaSVWILSALISFLPIHLGWH 140

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

19-299

1.26e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 39.89 E-value: 1.26e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  19 PKLQVVILVFLfitytlSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTTVTILKFLGSIISGDKiis 91
Cdd:cd15305     3 PALLILIIIIL------TIGGNILVIMAVSLEKKLQNATNFFLMSLAVadmlvgiLVMPVSLIAILYDYAWPLPRYL--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  92 fndCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQ-----KVFTCWLVSFLVIFPALMLVLHLDycgSNI 166
Cdd:cd15305    74 ---CPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRtkammKIAAVWTISIGISMPIPVIGLQDD---EKV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 167 IDHFACdyfpllqlSCSDTKFLeKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKA-------FSTCSSPMI 239
Cdd:cd15305   148 FVNGTC--------VLNDENFV-LIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVlgivfflFLIMWCPFF 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1195674356 240 VISISYGSCifmyikSSAADRASLTK--GVAILNTSVATMLNPFIYSLRNQQVKQAFMNMAR 299
Cdd:cd15305   219 ITNILSVLC------KEACDQKLMEEllNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIR 274

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

40-297

1.44e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 39.85 E-value: 1.44e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  40 NLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTtvtilkFLGSIIS-GDKIISF-----NDCIAQLFFLNLFGEIEFYLL 113
Cdd:cd15084    28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVT------LFGSSVSfSNNIVGFfvfgkTMCEFEGFMVSLTGIVGLWSL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 114 AAMSYDRYIAICKPLHYLTIMSQ-KVFTC---WLVSFLVIFPALMlvlhldycgsniidhFACDYFPL-LQLSCSDTKFL 188
Cdd:cd15084   102 AILAFERYLVICKPMGDFRFQQRhAVSGCaftWGWSLLWTSPPLF---------------GWSSYVPEgLRTSCGPNWYT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 189 EKMG---FFCAVFIVLFTLVL--VFLSYTYIIRTiLKIPSASQR-----SKAFSTCSSPMIVISISYGSCIFMYikSSAA 258
Cdd:cd15084   167 GGTNnnsYILALFVTCFALPLstIIFSYSNLLLT-LRAVAAQQKesettQRAEKEVTRMVIAMVMAFLICWLPY--ATFA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1195674356 259 DRASLTKGVAILNT---------SVATMLNPFIYSLRNQQVKQAFMNM 297
Cdd:cd15084   244 MVVATNKDVVIQPTlaslpsyfsKTATVYNPIIYVFMNKQFRSCLLEL 291

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

23-155

1.51e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 39.40 E-value: 1.51e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTTVtiLKFLGSIISGDKIisfndC 95
Cdd:cd15063     1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACadllvgtLVLPFSAV--NEVLDVWIFGHTW-----C 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1195674356  96 IAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALML 155
Cdd:cd15063    74 QIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKrakclIAGVWVLSFVICFPPLVG 138

7tmA_CysLTR

cd15921

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...

31-243

1.52e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320587 [Multi-domain] Cd Length: 283 Bit Score: 39.41 E-value: 1.52e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  31 ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDC--IAQLFFLNLFGEI 108
Cdd:cd15921     9 LIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACriILYVLYVNMYSSI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 109 efYLLAAMSYDRYIAICKPLHYLTIMSQKV--FTCWLVSFLVIFPALMLVLHLDYcgSNIIDHFACdyfplLQLSCSDTK 186
Cdd:cd15921    89 --YFLTALSVFRYLALVWPYLYLRVQTHSVagIICGLIWILMGLASSPLLFAKSK--QHDEGSTRC-----LELAHDAVD 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195674356 187 FLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSKAFSTCSSPMIVISI 243
Cdd:cd15921   160 KLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSRRKACALIIISL 216

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

23-155

1.82e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 39.24 E-value: 1.82e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV-------LEVPFTTVTILK---FLGSIISgDKIISF 92
Cdd:cd15051     1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVtdlllglLVLPFSAIYELRgewPLGPVFC-NIYISL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195674356  93 NDCIAQLFFLNLFgeiefyllaAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALML 155
Cdd:cd15051    80 DVMLCTASILNLF---------AISLDRYLAITAPLRYPSRVTPRrvaiaLAAIWVVSLAVSFLPIHL 138

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

22-155

1.97e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 39.16 E-value: 1.97e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  22 QVVILVFLF-ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLF 100
Cdd:cd15299     2 QVVLIAFLTgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 101 FLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALML 155
Cdd:cd15299    82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKragvmIGLAWVISFVLWAPAILF 141

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

35-294

2.24e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 38.99 E-value: 2.24e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  35 LSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILkfLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYLLA 114
Cdd:cd15070    13 CAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 115 AMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMlvlhldycGSNIIDHFACDYFPLLQLSCSDTKFLE 189
Cdd:cd15070    91 AIAVDRYLRVKLTVRYRIVTTQRriwlaLGLCWLVSFLVGLTPMF--------GWNRKPSLESVNTTPLQCQFTSVMRMD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 190 KM---GFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRS------KAFSTCSSPMIVISISYGS----CIFMYIKSS 256
Cdd:cd15070   163 YMvyfSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFREtgafygREFKTAKSLALVLFLFAVCwlplSIINCVVYF 242

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195674356 257 AADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15070   243 NPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

23-153

2.30e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 38.79 E-value: 2.30e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNF-------SVLEVPFTTVTILK---FLGSIISgDKIISF 92
Cdd:cd15329     1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLavsdllvALLVMPLAIIYELSgywPFGEILC-DVWISF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195674356  93 NDCIAQLFFLNLfgeiefyllAAMSYDRYIAICKPLHYLT-----IMSQKVFTCWLVSFLVIFPAL 153
Cdd:cd15329    80 DVLLCTASILNL---------CAISVDRYLVITRPLTYAVkrtpkRMALMIAIVWLLSALISIPPL 136

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

23-294

2.34e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 38.99 E-value: 2.34e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLE-------VPFT-TVTILK--FLGSIIsgdkiisf 92
Cdd:cd14971     1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADltfllfcVPFTaTIYPLPgwVFGDFM-------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  93 ndCIAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLvlhldycgsnii 167
Cdd:cd14971    73 --CKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRnalaaSGCIWVVSLAVAAPVLAL------------ 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 168 dHFACDYFPLLQLSCSD--TKFLEKMGFFCAVFIVLFTLVLVFLSYTY--IIRTILKIP------SASQRSKA------- 230
Cdd:cd14971   139 -HRLRNYTPGNRTVCSEawPSRAHRRAFALCTFLFGYLLPLLLICVCYaaMLRHLWRVAvrpvlsEGSRRAKRkvtrlvl 217

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1195674356 231 -----FSTCSSPMIVISISYGSCIFMYIKSSAADRaSLTKGVAILNTSVatmlNPFIYSLRNQQVKQAF 294
Cdd:cd14971   218 vvvvlFAACWGPIHAILLLVALGPFPLTYATYALR-IWAHCLAYSNSAV----NPVLYAFLSEHFRKAF 281

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

99-229

2.43e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 38.79 E-value: 2.43e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  99 LFFLNLFGEIefYLLAAMSYDRYIAICKPLHYLTIMSQKVFTC-----WLVSFLVIFPalMLVLHLDYCGSNIIDHfaCD 173
Cdd:cd14982    79 LFYINMYGSI--LFLTCISVDRYLAVVHPLKSRRLRRKRYAVGvcagvWILVLVASVP--LLLLRSTIAKENNSTT--CF 152

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1195674356 174 YFPLLQLscsdtKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTILKIPSASQRSK 229
Cdd:cd14982   153 EFLSEWL-----ASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSV 203

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

24-228

2.64e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 38.80 E-value: 2.64e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  24 VILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEV-------PFTTVTIlkFLGSIISGDKIisfndCI 96
Cdd:cd15074     2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLgisvfgyPLAIISA--FAHRWLFGDIG-----CV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  97 AQLFFLNLFGEIEFYLLAAMSYDRYIAICKPlHYLTIMSQKvFTCWLVSFLVIFPALMLVLHLDYCGSNIIDHF--ACDY 174
Cdd:cd15074    75 FYGFCGFLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRR-HVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFgtSCSI 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1195674356 175 -FPLLQLSCSDTKFLEKMGFFCavfiVLFTLVLVFLSYTYIIRTILKIPSASQRS 228
Cdd:cd15074   153 dWTGASASVGGMSYIISIFIFC----YLLPVLIIVFSYVKIIRKVKSSRKRVAGF 203

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

23-151

2.76e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 38.81 E-value: 2.76e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV------LEVPFTTVTILkfLGSIISGD---KIISFN 93
Cdd:cd14970     1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVadelflLGLPFLATSYL--LGYWPFGEvmcKIVLSV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195674356  94 DciaqlfFLNLFGEIefYLLAAMSYDRYIAICKP---LHYLTIMSQKVFTC--WLVSFLVIFP 151
Cdd:cd14970    79 D------AYNMFTSI--FCLTVMSVDRYLAVVHPvksLRFRTPRKAKLVSLcvWALSLVLGLP 133

7tmA_P2Y6_P2Y3-like

cd15968

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...

99-288

2.80e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320634 [Multi-domain] Cd Length: 285 Bit Score: 38.60 E-value: 2.80e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  99 LFFLNLFGEIefYLLAAMSYDRYIAICKPLHYLTIMSQK--VFTC---WLVSFLVIFPALM-----LVLHLDYCGSNIID 168
Cdd:cd15968    79 LFYFNLYGSI--LFLTCISVHRYLGICHPMRPWHKETRRaaWLTCvlvWILVFAQTLPILIfartgIIRNRTVCYDLAPP 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 169 HFACDYFPLlqlscsdTKFLEKMGFFCAVFIVLFTLVLVFLSytyIIRTI--LKIPSASQRSKAFSTcsspMIVISISYG 246
Cdd:cd15968   157 ALFPHYVPY-------GMALTVSGFLLPFSIILWCYCLVVRT---LCRTLgpAEPPAQARRRKSIRT----IVTVTLLFA 222

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1195674356 247 SC---------IFMYIKSSAADRASLTKGVAILN------TSVATMLNPFIYSLRNQ 288
Cdd:cd15968   223 LCflpfhitrtIYLAVRVTPGVPCHVLEAVAACYkitrplASANSVLNPLLYFLTKK 279

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

31-151

3.50e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 38.26 E-value: 3.50e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  31 ITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEV-------PFTTVTILkfLGSIISGDKIisfndCIAQLFFLN 103
Cdd:cd15979     9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfcmPFTLIPNL--MGTFIFGEVI-----CKAVAYLMG 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195674356 104 LFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFP 151
Cdd:cd15979    82 VSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRShayrvIAATWLLSGLIMIP 134

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

35-294

3.54e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 38.29 E-value: 3.54e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  35 LSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILkfLGSIISGDKIISFNDCIAQLFFLNLFGEIEFYLLA 114
Cdd:cd15071    13 VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILALL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 115 AMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVifpALMLVLHLDYCGSNIIDHFACDYFPLLQLSCS-----D 184
Cdd:cd15071    91 AIAVDRYLRVKIPTRYKSVVTPRraavaIAGCWILSFLV---GLTPMFGWNNLNAVERAWAANSSMGELVIKCQfetviS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 185 TKFLEKMGFFCAVFIVLFTLVLVFLSYTYIIRTIL--KIPSASQRSKAF--------STCSSPMIVISISY-----GSCI 249
Cdd:cd15071   168 MEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQLnkKVSSSSSDPQKYygkelkiaKSLALILFLFALSWlplhiLNCI 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195674356 250 FMYIKSsaADRASLTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15071   248 TLFCPS--CKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

23-137

3.66e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 38.22 E-value: 3.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIIS--------GDKIISFND 94
Cdd:cd15350     1 VVPEEVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILAdmgylnrrGPFETKLDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1195674356  95 CIAQLFFLNLFGEIefYLLAAMSYDRYIAICKPLHYLTIMSQK 137
Cdd:cd15350    81 IMDSLFCLSLLGSI--FSILAIAADRYITIFHALRYHNIMTMR 121

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

23-151

5.23e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 37.93 E-value: 5.23e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFItYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIISGDKIISFNDCIAQLFFL 102
Cdd:cd15978     2 VRILLYSLI-FLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195674356 103 NLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQ----KVFTC-WLVSFLVIFP 151
Cdd:cd15978    81 GISVSVSTFNLVAISLERYSAICKPLKSRVWQTKshalKVIAAtWCLSFTIMLP 134

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

23-137

5.56e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 37.85 E-value: 5.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFSVLE-------VPFTtvTILKFLGSIISGDkiiSFNDC 95
Cdd:cd15062     1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADlllsftvLPFS--ATLEVLGYWAFGR---IFCDV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195674356  96 IAQLFFLNLFGEIefYLLAAMSYDRYIAICKPLHYLTIMSQK 137
Cdd:cd15062    76 WAAVDVLCCTASI--MSLCVISVDRYIGVRYPLNYPTIVTAR 115

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

22-153

7.19e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 37.36 E-value: 7.19e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  22 QVVILVFLFItytLSITGNLTIITLTLLDSHLQTPMYFFLRNFSV--LEVPFTTVT---ILKFLGSIISGD---KIISFN 93
Cdd:cd14986     3 RVAVLGVLFV---FTLVGNGLVILVLRRKRKKRSRVNIFILNLAIadLVVAFFTVLtqiIWEATGEWVAGDvlcRIVKYL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1195674356  94 DCIAqlfflnLFGEIefYLLAAMSYDRYIAICKPLHYLTIMSQ---KVFTCWLVSFLVIFPAL 153
Cdd:cd14986    80 QVVG------LFAST--YILVSMSLDRYQAIVKPMSSLKPRKRarlMIVVAWVLSFLFSIPQL 134

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

111-151

7.64e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 37.49 E-value: 7.64e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1195674356 111 YLLAAMSYDRYIAICKPLHYLTIMSQK----VFTCWLVSFLVIFP 151
Cdd:cd15385    89 YMLVMMTADRYIAICHPLKTLQQPTKRsylmIGSAWALSFILSTP 133

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

18-154

7.77e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 37.45 E-value: 7.77e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  18 DPKLQVVILVFLFITYTLSITGNLTIITLtLLDSHLQTPMYFFLRNFSVLEVPFTTVTILKFLGSIIsgdKIISFNDCI- 96
Cdd:PHA03087   36 YDTNSTILIVVYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYIL---FQWSFGEFAc 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195674356  97 ---AQLFFLNLFGEIEFylLAAMSYDRYIAICKPLHYL---TIMSQKVFTC--WLVSFLVIFPALM 154
Cdd:PHA03087  112 kivSGLYYIGFYNSMNF--ITVMSVDRYIAIVHPVKSNkinTVKYGYIVSLviWIISIIETTPILF 175

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

23-294

7.87e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 37.37 E-value: 7.87e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNFS-------VLEVPFTTVTILkfLGSIISGDKIisfndC 95
Cdd:cd15206     1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAvsdlllaVFCMPFTLVGQL--LRNFIFGEVM-----C 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  96 IAQLFFLNLFGEIEFYLLAAMSYDRYIAICKPLHYLTIMSQK-----VFTCWLVSFLVIFPALMLVLHLDYCGSNIidHF 170
Cdd:cd15206    74 KLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLShaykvIAGIWLLSFLIMSPILVFSNLIPMSRPGG--HK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356 171 ACDYFPLLQLSCSDTKFLEkmgffcaVFIVLFTLVLVFLSYTYIIRTILKipsASQR--------SKAFSTCSSPMIVIS 242
Cdd:cd15206   152 CREVWPNEIAEQAWYVFLD-------LMLLVIPGLVMSVAYGLISWTLLE---AKKRvirmlfviVVEFFICWTPLYVIN 221

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195674356 243 ISYgscifMYIKSSAADRAS-LTKGVAILNTSVATMLNPFIYSLRNQQVKQAF 294
Cdd:cd15206   222 TWK-----AFDPPSAARYVSsTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

111-176

8.43e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 37.47 E-value: 8.43e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195674356 111 YLLAAMSYDRYIAICKPLHYLTIMSQKVF----TCWLVSFLVIFPALMLV-LHLDYCGSNIIDHFACDYFP 176
Cdd:cd15386    89 YMLIMMTVDRYIAVCHPLRTLQQPSRQAYlmigATWLLSCILSLPQVFIFsLREVDQGSGVLDCWADFGFP 159

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

23-154

8.44e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 37.34 E-value: 8.44e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195674356  23 VVILVFLFITYTLSITGNLTIITLTLLDSHLQTPMYFFLRNF-------SVLEVPFTTVTILKFL----GSIISgdKIIS 91
Cdd:cd15392     1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLalsdilmAVFCVPFSFIALLILQywpfGEFMC--PVVN 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1195674356  92 FNDCIAQLfflnlfgeIEFYLLAAMSYDRYIAICKPLHYLTIMSQKVF---TCWLVSFLVIFPALM 154
Cdd:cd15392    79 YLQAVSVF--------VSAFTLVAISIDRYVAIMWPLRPRMTKRQALLliaVIWIFALATALPIAI 136

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01