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Conserved domains on  [gi|1190421023|ref|XP_020860813|]
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glucosamine-6-phosphate isomerase 1 [Phascolarctos cinereus]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10011441)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-258 3.87e-149

glucosamine-6-phosphate deaminase; Provisional


:

Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 418.08  E-value: 3.87e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQFQPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 161 TLAVDTILYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCD 240
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                         250
                  ....*....|....*...
gi 1190421023 241 EDATLELKVKTVKYFKGL 258
Cdd:PRK00443  241 EAAASELKVKTVKYFTEL 258
 
Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-258 3.87e-149

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 418.08  E-value: 3.87e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQFQPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 161 TLAVDTILYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCD 240
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                         250
                  ....*....|....*...
gi 1190421023 241 EDATLELKVKTVKYFKGL 258
Cdd:PRK00443  241 EAAASELKVKTVKYFTEL 258
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-258 2.35e-134

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 380.31  E-value: 2.35e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQFQPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 161 TLAVDTILYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 1190421023 241 EDATLELKVKTVKYFKGL 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-247 1.93e-132

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 374.51  E-value: 1.93e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  11 QASEWAAKYIRNRIVQFqpgptRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRDHPESFHTYMW 90
Cdd:cd01399     2 EMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  91 NNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVKTLAVDTILYN 170
Cdd:cd01399    77 ENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQAN 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1190421023 171 SRYFDGElSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCDEDATLEL 247
Cdd:cd01399   157 ARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 7.37e-110

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 317.87  E-value: 7.37e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILED----ALQASEWAAKYIRNRIVQfqpgpTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVG 76
Cdd:COG0363     2 MRVIIFPDaeelAAAAAERAAERIAEAIAE-----KGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  77 IPRDHPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASR 156
Cdd:COG0363    77 LPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 157 T-RVKTLAVDTILYNSRYFDGeLSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRV 235
Cdd:COG0363   157 TdRVVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNV 235

                         250
                  ....*....|...
gi 1190421023 236 VFVCDEDATLELK 248
Cdd:COG0363   236 TWFLDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-223 1.41e-17

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 79.20  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   7 EDALQASewAAKYIRNRIVQFQPGPTRyFTLGLPTGSTPLPFYKKLIEYYknGDLSFKYVKTFNMDE-YVgiPRDHPES- 84
Cdd:pfam01182   3 AEALAQA--LAERLAEALEAALAERGR-FTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSn 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  85 FHTYMwNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIE------LCVGGIGTEGHIA--FnePGSSLASR 156
Cdd:pfam01182  76 YGMAR-EALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPDLelpvfdLVLLGMGPDGHTAslF--PGSPALEE 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1190421023 157 TRVKTLAVDtilyNSRyfdgelsKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHM 223
Cdd:pfam01182 153 TDRLVVAVT----DSP-------KPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-258 3.87e-149

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 418.08  E-value: 3.87e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQFQPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 161 TLAVDTILYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCD 240
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                         250
                  ....*....|....*...
gi 1190421023 241 EDATLELKVKTVKYFKGL 258
Cdd:PRK00443  241 EAAASELKVKTVKYFTEL 258
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 7.82e-144

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 404.14  E-value: 7.82e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQFQPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:PTZ00285    1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:PTZ00285   81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 161 TLAVDTILYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCD 240
Cdd:PTZ00285  161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                         250
                  ....*....|...
gi 1190421023 241 EDATLELKVKTVK 253
Cdd:PTZ00285  241 EDATLELKVKTTK 253
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-258 2.35e-134

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 380.31  E-value: 2.35e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQFQPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 161 TLAVDTILYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 1190421023 241 EDATLELKVKTVKYFKGL 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-247 1.93e-132

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 374.51  E-value: 1.93e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  11 QASEWAAKYIRNRIVQFqpgptRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRDHPESFHTYMW 90
Cdd:cd01399     2 EMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  91 NNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVKTLAVDTILYN 170
Cdd:cd01399    77 ENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQAN 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1190421023 171 SRYFDGElSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCDEDATLEL 247
Cdd:cd01399   157 ARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 7.37e-110

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 317.87  E-value: 7.37e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILED----ALQASEWAAKYIRNRIVQfqpgpTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVG 76
Cdd:COG0363     2 MRVIIFPDaeelAAAAAERAAERIAEAIAE-----KGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  77 IPRDHPESFHTYMWNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASR 156
Cdd:COG0363    77 LPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 157 T-RVKTLAVDTILYNSRYFDGeLSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRV 235
Cdd:COG0363   157 TdRVVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNV 235

                         250
                  ....*....|...
gi 1190421023 236 VFVCDEDATLELK 248
Cdd:COG0363   236 TWFLDEAAASLLT 248
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 4-247 4.42e-68

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 222.98  E-value: 4.42e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   4 IILEDALQASEWAAKYIRNRIVQFQpGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRDHPE 83
Cdd:PRK02122   31 DIFESSEEASRAVAQEIATLIRERQ-AEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQ 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  84 SFHTYMWNNFFKHIDISPTNAYILDGNAS--DLQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVKT 161
Cdd:PRK02122  110 SYHRFMKENLFDHVDIPPENIHIPDGTIPkeEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVT 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 162 LAVDTILYNSRYFDGElSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVCDE 241
Cdd:PRK02122  190 LDHITRRDAASDFFGE-ENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDL 268


                  ....*.
gi 1190421023 242 DATLEL 247
Cdd:PRK02122  269 AAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 14-239 2.35e-35

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 125.16  E-value: 2.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  14 EWAAKYIRNRIVQFqPGPTRYFTLGLPTGSTPLPFYKKLIEYYKNGdlSFKYVKTFNMDEYVGIPrDHPESFHTYMWNNF 93
Cdd:cd00458     2 KEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPL-DSDQSNFRQAKLLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  94 FKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIELCVGGIGteghiafnepgsslasrtrvktlavdtilynsry 173
Cdd:cd00458    78 FEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG---------------------------------- 123

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1190421023 174 fdgelskvptmvltvgvgtvMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVC 239
Cdd:cd00458   124 --------------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-236 5.78e-32

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 118.01  E-value: 5.78e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQfQPGptryFTLGLPTGSTPLPFYKKLIEYYKNGDLSFKYVKTFNMDEYVGIPRD 80
Cdd:PRK09762    1 QTLQQVENYTALSERASEYLLAVIRS-KPD----AVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNNFFKHIDISPTNAYILDGNASDlQTECDTFEKKIREAGGIELCVGGIGTEGHIAFNEPGSSLASRTRVK 160
Cdd:PRK09762   76 MPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHIS 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1190421023 161 TLAVDTILYNSRYFDGelsKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVV 236
Cdd:PRK09762  155 QLDARTQQHEMLKTAG---RPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFI 227
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 3.71e-29

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 111.00  E-value: 3.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   1 MKLIILEDALQASEWAAKYIRNRIVQfqpgpTRYFTLGLPTGSTPLPFYKKLIEYYKNGDLsFKYVKTFNMDEyvgIPRD 80
Cdd:PRK12358    1 MKIIITKDYEEMSRVAAHHLLGYMSK-----TKRVNLAITAGSTPKGMYEYLITLVKGKAW-YDNVHYYNFDE---IPFR 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  81 HPESFHTYMWNnfFKHIDISPtnAYILDGNASDLQTECDT-FEKKIREAGGIELCVGGIGTEGHIAFNEPG-SSLASRTR 158
Cdd:PRK12358   72 GKEGEGVTITN--LRNLFFTP--AGIKEENIHKLTIDNYReHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 159 VKTLAVDTI-LYNSRYFDGELSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVF 237
Cdd:PRK12358  148 EVPIQGEMVdIVAHGELGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTV 227

                         250
                  ....*....|
gi 1190421023 238 VCDEDATLEL 247
Cdd:PRK12358  228 ILDEAAAAEL 237
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-223 1.41e-17

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 79.20  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023   7 EDALQASewAAKYIRNRIVQFQPGPTRyFTLGLPTGSTPLPFYKKLIEYYknGDLSFKYVKTFNMDE-YVgiPRDHPES- 84
Cdd:pfam01182   3 AEALAQA--LAERLAEALEAALAERGR-FTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSn 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  85 FHTYMwNNFFKHIDISPTNAYILDGNASDLQTECDTFEKKIREAGGIE------LCVGGIGTEGHIA--FnePGSSLASR 156
Cdd:pfam01182  76 YGMAR-EALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPDLelpvfdLVLLGMGPDGHTAslF--PGSPALEE 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1190421023 157 TRVKTLAVDtilyNSRyfdgelsKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEGISHM 223
Cdd:pfam01182 153 TDRLVVAVT----DSP-------KPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 13-239 3.65e-17

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 78.37  E-value: 3.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  13 SEWAAKYIRNRIVQF--QPGptrYFTLGLPTGSTPLPFYKKLIEYYKngdLSFKYVKTFNMDE-YVgiPRDHPES-FHTY 88
Cdd:cd01400     4 AEALADRIAEALAAAiaKRG---RFSLALSGGSTPKPLYELLAAAPA---LDWSKVHVFLGDErCV--PPDDPDSnYRLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  89 MwNNFFKHIDISPTNAYILDGNAsDLQTECDTFEKKIREAGG----IELCVGGIGTEGHIA--FnePGSSLASRTRVKTL 162
Cdd:cd01400    76 R-EALLSHVAIPAANIHPIPTEL-GPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTAslF--PGHPALLEETDRLV 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1190421023 163 AVdtilynsrYFDGELSKVPTMVLTVGVgtVMDAREVMILITGAQKALALHKAIEEGISHMWTVSALQQHPRVVFVC 239
Cdd:cd01400   152 VA--------VTDSPKPPPERITLTLPV--LNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 34-219 1.80e-04

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 42.15  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023  34 YFTLGLPTGSTpLPFYKKLIE--YYKNGDLSFKYVktFNMDEYVgIPRDHPESFHTYMWNNFFKHIDISPTNAYILDGNA 111
Cdd:PLN02360   43 VFAIALSGGSL-ISFMGKLCEapYNKTVDWAKWYI--FWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190421023 112 SdLQTECDTFEKKIREAGGI--------------ELCVGGIGTEGHIAFNEPG-SSLASRTRVKTLAVDTilynsryfdg 176
Cdd:PLN02360  119 T-AEEAATDYEFAIRQLVKTrtigvsdisdcpkfDLILLGMGSDGHVASLFPNhPALEEKDDWVTFITDS---------- 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1190421023 177 elSKVPTMVLTVGVGTVMDAREVMILITGAQKALALHKAIEEG 219
Cdd:PLN02360  188 --PKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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