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Conserved domains on  [gi|1143397138|ref|XP_019953029|]
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PREDICTED: laminin subunit alpha-2-like [Paralichthys olivaceus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 19-271 6.18e-95

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


:

Pssm-ID: 214532  Cd Length: 238  Bit Score: 294.27  E-value: 6.18e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138   19 AGQQRGLFPAVLNLASMADITANATCGSTGPEMFCKLVEHVPGQPvknsQCRICNQRSakPVEHHPIEYAIDGTN----R 94
Cdd:smart00136   1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHTEQGK----KCDYCDARN--PRRSHPAENLTDGNNpnnpT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138   95 WWQSPSIKNGMeyHYVTITLDLKQVFQIAYLIIKAAnSPRPGNWVLERSIDGVTFEPWQYYAiteTECLTRFNINPRRGP 174
Cdd:smart00136  75 WWQSEPLSNGP--QNVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  175 PSYTrDDEVICTSFYSKIHPLENGEIHTSLINGRPSAEDP--SPTLLNFTSARYIRLVFQRIRTLNADLMtltlrdprDV 252
Cdd:smart00136 149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELM--------DD 219

                          250
                   ....*....|....*....
gi 1143397138  253 DPIVTRRYYYSIKDISVGG 271
Cdd:smart00136 220 RPEVTRRYYYAISDIAVGG 238
Laminin_B pfam00052
Laminin B (Domain IV);
566-682 3.30e-30

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 115.83  E-value: 3.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 566 YWNAPGLYLGNKLPAYGGSVVYAVSYTTDQQEQMAvrvTSEPDLIIEGAGMKIVDRRFGQP-VYPSSPSTNHIVLLPQNF 644
Cdd:pfam00052   1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSL---NSEPDVILEGNGLRLSYSSPDQPpPDPGQEQTYSVRLHEENW 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1143397138 645 lVSETEQVISRRDFLSVLAKVTRVAVRASYSTEPSAVY 682
Cdd:pfam00052  78 -RDSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVS 114
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 399-451 1.31e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1143397138 399 PCSCDPHGSVSQSCVADSsqatppqpvGSCQCKEGFGGRRCDRCAVGYMGYPS 451
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGT---------GQCECKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-501 2.74e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 2.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1143397138 455 CNCSMEGSTNDDpCIT---PCTCKENVEGENCDRCKLGFYDLQGDNGRGC 501
Cdd:pfam00053   1 CDCNPHGSLSDT-CDPetgQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 273-320 2.38e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.04  E-value: 2.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1143397138 273 CICYGHA---KACPLNTVTkkfsCECEHNTCGESCDRCCPGYHQQPWMAGT 320
Cdd:cd00055     2 CDCNGHGslsGQCDPGTGQ----CECKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 19-271 6.18e-95

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 294.27  E-value: 6.18e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138   19 AGQQRGLFPAVLNLASMADITANATCGSTGPEMFCKLVEHVPGQPvknsQCRICNQRSakPVEHHPIEYAIDGTN----R 94
Cdd:smart00136   1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHTEQGK----KCDYCDARN--PRRSHPAENLTDGNNpnnpT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138   95 WWQSPSIKNGMeyHYVTITLDLKQVFQIAYLIIKAAnSPRPGNWVLERSIDGVTFEPWQYYAiteTECLTRFNINPRRGP 174
Cdd:smart00136  75 WWQSEPLSNGP--QNVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  175 PSYTrDDEVICTSFYSKIHPLENGEIHTSLINGRPSAEDP--SPTLLNFTSARYIRLVFQRIRTLNADLMtltlrdprDV 252
Cdd:smart00136 149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELM--------DD 219

                          250
                   ....*....|....*....
gi 1143397138  253 DPIVTRRYYYSIKDISVGG 271
Cdd:smart00136 220 RPEVTRRYYYAISDIAVGG 238
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
25-271 8.05e-89

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 277.93  E-value: 8.05e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  25 LFPAVLNLASMADITANATCGSTGPEMFCKLVEHVPGQpvknsQCRICNqrSAKPVEHHPIEYAIDGTNR----WWQSPS 100
Cdd:pfam00055   1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGLEGGK-----KCFICD--SRDPHNSHPPSNLTDSNNGtnetWWQSET 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 101 IKngMEYHYVTITLDLKQVFQIAYLIIKAAnSPRPGNWVLERSID-GVTFEPWQYYAiteTECLTRFNINPRrgPPSYTR 179
Cdd:pfam00055  74 GV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYFA---SDCRRTFGRPSG--PSRGIK 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 180 DDEVICTSFYSKIHPLENGEIHTSLINGRPSAE--DPSPTLLNFTSARYIRLVFQRIRTLNadlmtltlrDPRDVDPIVT 257
Cdd:pfam00055 146 DDEVICTSEYSDISPLTGGEVIFSTLEGRPSANifDYSPELQDWLTATNIRIRLLRLHTLG---------DELLDDPSVL 216

                         250
                  ....*....|....
gi 1143397138 258 RRYYYSIKDISVGG 271
Cdd:pfam00055 217 RKYYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
566-682 3.30e-30

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 115.83  E-value: 3.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 566 YWNAPGLYLGNKLPAYGGSVVYAVSYTTDQQEQMAvrvTSEPDLIIEGAGMKIVDRRFGQP-VYPSSPSTNHIVLLPQNF 644
Cdd:pfam00052   1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSL---NSEPDVILEGNGLRLSYSSPDQPpPDPGQEQTYSVRLHEENW 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1143397138 645 lVSETEQVISRRDFLSVLAKVTRVAVRASYSTEPSAVY 682
Cdd:pfam00052  78 -RDSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVS 114
LamB smart00281
Laminin B domain;
561-682 1.35e-25

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 102.34  E-value: 1.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  561 LGSAYYWNAPGLYLGNKLPAYGGSVVYAVSYTTdqQEQMavRVTSEPDLIIEGAGMKIVDRRFGQPvYPSSPSTNHIVLL 640
Cdd:smart00281   1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDG--RRGG--THVSAPDVILEGNGLRISHPAEGPP-LPDELTTVEVRFR 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1143397138  641 PQNFlVSETEQVISRRDFLSVLAKVTRVAVRASYSTEPSAVY 682
Cdd:smart00281  76 EENW-QYYGGRPVTREDLMMVLANLTAILIRATYSQQMAGSR 116
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 399-451 1.31e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1143397138 399 PCSCDPHGSVSQSCVADSsqatppqpvGSCQCKEGFGGRRCDRCAVGYMGYPS 451
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGT---------GQCECKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 400-457 2.33e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.21  E-value: 2.33e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1143397138 400 CSCDPHGSVSQSCvaDSSQatppqpvGSCQCKEGFGGRRCDRCAVGYMGYPSCQRCNC 457
Cdd:pfam00053   1 CDCNPHGSLSDTC--DPET-------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
400-450 1.72e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 50.77  E-value: 1.72e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1143397138  400 CSCDPHGSVSQSCVADSsqatppqpvGSCQCKEGFGGRRCDRCAVGYMGYP 450
Cdd:smart00180   1 CDCDPGGSASGTCDPDT---------GQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-501 2.74e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 2.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1143397138 455 CNCSMEGSTNDDpCIT---PCTCKENVEGENCDRCKLGFYDLQGDNGRGC 501
Cdd:pfam00053   1 CDCNPHGSLSDT-CDPetgQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 273-320 2.38e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.04  E-value: 2.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1143397138 273 CICYGHA---KACPLNTVTkkfsCECEHNTCGESCDRCCPGYHQQPWMAGT 320
Cdd:cd00055     2 CDCNGHGslsGQCDPGTGQ----CECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-501 2.43e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.99  E-value: 2.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1143397138  455 CNCSMEGSTND--DPCITPCTCKENVEGENCDRCKLGFYdlqGDNGRGC 501
Cdd:smart00180   1 CDCDPGGSASGtcDPDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-502 3.19e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.65  E-value: 3.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1143397138 454 RCNCSMEGSTNDDpCITP---CTCKENVEGENCDRCKLGFYDLQgDNGRGCE 502
Cdd:cd00055     1 PCDCNGHGSLSGQ-CDPGtgqCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
293-316 3.99e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.45  E-value: 3.99e-04
                           10        20
                   ....*....|....*....|....
gi 1143397138  293 CECEHNTCGESCDRCCPGYHQQPW 316
Cdd:smart00180  20 CECKPNVTGRRCDRCAPGYYGDGP 43
 
Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 19-271 6.18e-95

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 294.27  E-value: 6.18e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138   19 AGQQRGLFPAVLNLASMADITANATCGSTGPEMFCKLVEHVPGQPvknsQCRICNQRSakPVEHHPIEYAIDGTN----R 94
Cdd:smart00136   1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHTEQGK----KCDYCDARN--PRRSHPAENLTDGNNpnnpT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138   95 WWQSPSIKNGMeyHYVTITLDLKQVFQIAYLIIKAAnSPRPGNWVLERSIDGVTFEPWQYYAiteTECLTRFNINPRRGP 174
Cdd:smart00136  75 WWQSEPLSNGP--QNVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  175 PSYTrDDEVICTSFYSKIHPLENGEIHTSLINGRPSAEDP--SPTLLNFTSARYIRLVFQRIRTLNADLMtltlrdprDV 252
Cdd:smart00136 149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELM--------DD 219

                          250
                   ....*....|....*....
gi 1143397138  253 DPIVTRRYYYSIKDISVGG 271
Cdd:smart00136 220 RPEVTRRYYYAISDIAVGG 238
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
25-271 8.05e-89

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 277.93  E-value: 8.05e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  25 LFPAVLNLASMADITANATCGSTGPEMFCKLVEHVPGQpvknsQCRICNqrSAKPVEHHPIEYAIDGTNR----WWQSPS 100
Cdd:pfam00055   1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGLEGGK-----KCFICD--SRDPHNSHPPSNLTDSNNGtnetWWQSET 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 101 IKngMEYHYVTITLDLKQVFQIAYLIIKAAnSPRPGNWVLERSID-GVTFEPWQYYAiteTECLTRFNINPRrgPPSYTR 179
Cdd:pfam00055  74 GV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYFA---SDCRRTFGRPSG--PSRGIK 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 180 DDEVICTSFYSKIHPLENGEIHTSLINGRPSAE--DPSPTLLNFTSARYIRLVFQRIRTLNadlmtltlrDPRDVDPIVT 257
Cdd:pfam00055 146 DDEVICTSEYSDISPLTGGEVIFSTLEGRPSANifDYSPELQDWLTATNIRIRLLRLHTLG---------DELLDDPSVL 216

                         250
                  ....*....|....
gi 1143397138 258 RRYYYSIKDISVGG 271
Cdd:pfam00055 217 RKYYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
566-682 3.30e-30

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 115.83  E-value: 3.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138 566 YWNAPGLYLGNKLPAYGGSVVYAVSYTTDQQEQMAvrvTSEPDLIIEGAGMKIVDRRFGQP-VYPSSPSTNHIVLLPQNF 644
Cdd:pfam00052   1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSL---NSEPDVILEGNGLRLSYSSPDQPpPDPGQEQTYSVRLHEENW 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1143397138 645 lVSETEQVISRRDFLSVLAKVTRVAVRASYSTEPSAVY 682
Cdd:pfam00052  78 -RDSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVS 114
LamB smart00281
Laminin B domain;
561-682 1.35e-25

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 102.34  E-value: 1.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143397138  561 LGSAYYWNAPGLYLGNKLPAYGGSVVYAVSYTTdqQEQMavRVTSEPDLIIEGAGMKIVDRRFGQPvYPSSPSTNHIVLL 640
Cdd:smart00281   1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDG--RRGG--THVSAPDVILEGNGLRISHPAEGPP-LPDELTTVEVRFR 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1143397138  641 PQNFlVSETEQVISRRDFLSVLAKVTRVAVRASYSTEPSAVY 682
Cdd:smart00281  76 EENW-QYYGGRPVTREDLMMVLANLTAILIRATYSQQMAGSR 116
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 399-451 1.31e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.98  E-value: 1.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1143397138 399 PCSCDPHGSVSQSCVADSsqatppqpvGSCQCKEGFGGRRCDRCAVGYMGYPS 451
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGT---------GQCECKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 400-457 2.33e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.21  E-value: 2.33e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1143397138 400 CSCDPHGSVSQSCvaDSSQatppqpvGSCQCKEGFGGRRCDRCAVGYMGYPSCQRCNC 457
Cdd:pfam00053   1 CDCNPHGSLSDTC--DPET-------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
400-450 1.72e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 50.77  E-value: 1.72e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1143397138  400 CSCDPHGSVSQSCVADSsqatppqpvGSCQCKEGFGGRRCDRCAVGYMGYP 450
Cdd:smart00180   1 CDCDPGGSASGTCDPDT---------GQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-501 2.74e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 2.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1143397138 455 CNCSMEGSTNDDpCIT---PCTCKENVEGENCDRCKLGFYDLQGDNGRGC 501
Cdd:pfam00053   1 CDCNPHGSLSDT-CDPetgQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 273-320 2.38e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.04  E-value: 2.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1143397138 273 CICYGHA---KACPLNTVTkkfsCECEHNTCGESCDRCCPGYHQQPWMAGT 320
Cdd:cd00055     2 CDCNGHGslsGQCDPGTGQ----CECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-501 2.43e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.99  E-value: 2.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1143397138  455 CNCSMEGSTND--DPCITPCTCKENVEGENCDRCKLGFYdlqGDNGRGC 501
Cdd:smart00180   1 CDCDPGGSASGtcDPDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-502 3.19e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.65  E-value: 3.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1143397138 454 RCNCSMEGSTNDDpCITP---CTCKENVEGENCDRCKLGFYDLQgDNGRGCE 502
Cdd:cd00055     1 PCDCNGHGSLSGQ-CDPGtgqCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
293-316 3.99e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.45  E-value: 3.99e-04
                           10        20
                   ....*....|....*....|....
gi 1143397138  293 CECEHNTCGESCDRCCPGYHQQPW 316
Cdd:smart00180  20 CECKPNVTGRRCDRCAPGYYGDGP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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