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Conserved domains on  [gi|1079413036|ref|XP_018514859|]
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probable inactive lysine-specific demethylase JMJ19 isoform X1 [Brassica rapa]

Protein Classification

lysine-specific demethylase family protein( domain architecture ID 10650807)

lysine-specific demethylase family protein is a jumonji C domain-containing (JMJD) protein and may have histone demethylase activity; contains a C5HC2 zinc finger

CATH:  2.60.120.10
EC:  1.14.11.-
Gene Ontology:  GO:0046872|GO:0032452|GO:0006355|GO:0008270
PubMed:  25372754|37832177|35558079|19478949|14697267|17210253|12665246
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 393-506 1.11e-31

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 119.33  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079413036 393 RLSVGMFLSSQLWKSEKDRLYSLCYLHVGAPRVWYSVAGCHRSKLMNLFPEMSGELQSKMSREPVMIMSPYALNMEGIPV 472
Cdd:pfam02373   1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFGGEQPDDLLHLNTIISPKQLRENGIPV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1079413036 473 TRCVQNPGQYVILFPGSCYSAVNCGFNCLEKANF 506
Cdd:pfam02373  81 YRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjN smart00545
Small domain found in the jumonji family of transcription factors; To date, this domain always ...
 172-213 1.16e-19

Small domain found in the jumonji family of transcription factors; To date, this domain always co-occurs with the JmjC domain (although the reverse is not true).


:

Pssm-ID: 128818  Cd Length: 42  Bit Score: 82.70  E-value: 1.16e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1079413036  172 EAPVFNPTEEEFSDTLSYIATLRDKAEPYGICCVVPPPSWKP 213
Cdd:smart00545   1 EIPVFYPTMEEFKDPLAYISKIRPQAEKYGICKVVPPKSWKP 42
zf-C5HC2 pfam02928
C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. ...
 613-665 1.30e-15

C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.


:

Pssm-ID: 460750  Cd Length: 54  Bit Score: 71.51  E-value: 1.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1079413036 613 CCFCFVDLHFSAVQCSCSDERFSCLSHVRNLCACPSGKKRFL-YRYTIDELNVL 665
Cdd:pfam02928   1 CSFCKAYCYLSAVTCSKCSGKVVCLRHAKELCSDCPPSKRTLlYRYTDDELEAL 54
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 393-506 1.11e-31

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 119.33  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079413036 393 RLSVGMFLSSQLWKSEKDRLYSLCYLHVGAPRVWYSVAGCHRSKLMNLFPEMSGELQSKMSREPVMIMSPYALNMEGIPV 472
Cdd:pfam02373   1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFGGEQPDDLLHLNTIISPKQLRENGIPV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1079413036 473 TRCVQNPGQYVILFPGSCYSAVNCGFNCLEKANF 506
Cdd:pfam02373  81 YRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjN smart00545
Small domain found in the jumonji family of transcription factors; To date, this domain always ...
 172-213 1.16e-19

Small domain found in the jumonji family of transcription factors; To date, this domain always co-occurs with the JmjC domain (although the reverse is not true).


Pssm-ID: 128818  Cd Length: 42  Bit Score: 82.70  E-value: 1.16e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1079413036  172 EAPVFNPTEEEFSDTLSYIATLRDKAEPYGICCVVPPPSWKP 213
Cdd:smart00545   1 EIPVFYPTMEEFKDPLAYISKIRPQAEKYGICKVVPPKSWKP 42
zf-C5HC2 pfam02928
C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. ...
 613-665 1.30e-15

C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.


Pssm-ID: 460750  Cd Length: 54  Bit Score: 71.51  E-value: 1.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1079413036 613 CCFCFVDLHFSAVQCSCSDERFSCLSHVRNLCACPSGKKRFL-YRYTIDELNVL 665
Cdd:pfam02928   1 CSFCKAYCYLSAVTCSKCSGKVVCLRHAKELCSDCPPSKRTLlYRYTDDELEAL 54
JmjN pfam02375
jmjN domain;
174-207 2.32e-13

jmjN domain;


Pssm-ID: 460542  Cd Length: 34  Bit Score: 64.23  E-value: 2.32e-13
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1079413036 174 PVFNPTEEEFSDTLSYIATLRDKAEPYGICCVVP 207
Cdd:pfam02375   1 PVFYPTEEEFKDPLKYIEKIRPLGEKYGICKIVP 34
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 393-506 1.11e-31

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 119.33  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079413036 393 RLSVGMFLSSQLWKSEKDRLYSLCYLHVGAPRVWYSVAGCHRSKLMNLFPEMSGELQSKMSREPVMIMSPYALNMEGIPV 472
Cdd:pfam02373   1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFGGEQPDDLLHLNTIISPKQLRENGIPV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1079413036 473 TRCVQNPGQYVILFPGSCYSAVNCGFNCLEKANF 506
Cdd:pfam02373  81 YRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
JmjN smart00545
Small domain found in the jumonji family of transcription factors; To date, this domain always ...
 172-213 1.16e-19

Small domain found in the jumonji family of transcription factors; To date, this domain always co-occurs with the JmjC domain (although the reverse is not true).


Pssm-ID: 128818  Cd Length: 42  Bit Score: 82.70  E-value: 1.16e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1079413036  172 EAPVFNPTEEEFSDTLSYIATLRDKAEPYGICCVVPPPSWKP 213
Cdd:smart00545   1 EIPVFYPTMEEFKDPLAYISKIRPQAEKYGICKVVPPKSWKP 42
zf-C5HC2 pfam02928
C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. ...
 613-665 1.30e-15

C5HC2 zinc finger; Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.


Pssm-ID: 460750  Cd Length: 54  Bit Score: 71.51  E-value: 1.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1079413036 613 CCFCFVDLHFSAVQCSCSDERFSCLSHVRNLCACPSGKKRFL-YRYTIDELNVL 665
Cdd:pfam02928   1 CSFCKAYCYLSAVTCSKCSGKVVCLRHAKELCSDCPPSKRTLlYRYTDDELEAL 54
JmjN pfam02375
jmjN domain;
174-207 2.32e-13

jmjN domain;


Pssm-ID: 460542  Cd Length: 34  Bit Score: 64.23  E-value: 2.32e-13
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1079413036 174 PVFNPTEEEFSDTLSYIATLRDKAEPYGICCVVP 207
Cdd:pfam02375   1 PVFYPTEEEFKDPLKYIEKIRPLGEKYGICKIVP 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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