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Conserved domains on  [gi|1926259031|ref|XP_017535131|]
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alpha-tectorin [Manis javanica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 1.11e-66

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 222.30  E-value: 1.11e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031    98 PFWADVHNGIRGEIYYRETTDPVILKRATKDVRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926259031   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1800-2054 2.01e-59

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 205.70  E-value: 2.01e-59
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1800 TCKAAQMEVSVSKCKLFQLGFEREGVRINDRQCSGV---EGEDFISFQINNTKgnCGNIVQSNSTHIVYKNTIWIesANN 1876
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQftdATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1877 TGNVITRDRTISVEFSCAYELDLKISLDSVVKPMLSVINltVPTQEGSFITKMALYKNASYKHPYRQGEVVLttRDVLYV 1956
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1957 GVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEGGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2034
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1926259031  2035 CAVSLCDSEKYS--CKINCPQN 2054
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 9.83e-46

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 162.54  E-value: 9.83e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1926259031  402 VNDLVTSLPVTLDLGAVKIYQSGM-STAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 1.82e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.66  E-value: 1.82e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTgnrPSSDTFPKFIVTATNEDRDpSLALWVKQVDVTVFGYSLVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD---CSEEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTYLSITVPRSMRNSTYGLCGRYNGNPDDDLEMPMGV 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 3.69e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.41  E-value: 3.69e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1487 CLAAGSGVFRTFDGAFLRFPANCAFVLSTICQKLPTISFQLIINFDRWSSPNlTVISPVYFYINEEQILISDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926259031 1567 TQVNVPFIT-GLATKIYSrEGFLVIDTSPD--IQIHYNGFNVIKISIGERLQNKVCGLCGNFNGDLTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILG-SGFVVVDLSPGvgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 1.59e-31

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.13  E-value: 1.59e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   703 QGCFPKR-QTVCLLSQNQVLHTFDGAAYTFPSDFSYTLLKTCPERPEYlEIDISKKKPEAGPTWLRGLRILVANQEVKIG 781
Cdd:smart00216    1 WCCTQEEcSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   782 GVGAsEVKLNGQEVELPFFHPLGKLEIYRNKNSTTVE-SKGIVSVQYSDVGLLYIRLSTAYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDNG-KVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1926259031   861 CLPTG 865
Cdd:smart00216  159 RTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 5.88e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 97.03  E-value: 5.88e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031   517 LYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRVQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 2.00e-17

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 78.54  E-value: 2.00e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926259031   905 FYRSRARCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNQSELCDSVARYASTCKNADVQVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 7.32e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 7.32e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031 1300 LCGLIpSVNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNDTSC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 3.59e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.58  E-value: 3.59e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  597 CPSFSHYSVCTSSCPNTCSDLTASRNCAAPCTEGCECDDGFVLSTS-QCVPLHKC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 2.06e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 69.27  E-value: 2.06e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHSC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 1.16e-12

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 64.26  E-value: 1.16e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  984 CPENSHFEECM-MCTVTCETLALGPVCVDSCSEGCQCDEGYAL-QGSQCVTRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGsACPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1679-1752 9.78e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 59.66  E-value: 9.78e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  1679 KMQGDGYCTKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YNHRKFQLCGSLAAYGESCRSFGVLSTEWIEKENC 1752
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2084-2116 4.00e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1926259031 2084 EDNGGCEQICTSRVEGPLCSCVTG-TLQEDGRSC 2116
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 652-706 7.49e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam12714:

Pssm-ID: 450195  Cd Length: 54  Bit Score: 39.21  E-value: 7.49e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  652 CDFDGHYYTMGEFfWATANCTVQCLCEeGGDVYCFNKTCRSGEACAVEDGYQGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 1.11e-66

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 222.30  E-value: 1.11e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031    98 PFWADVHNGIRGEIYYRETTDPVILKRATKDVRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926259031   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1800-2054 2.01e-59

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 205.70  E-value: 2.01e-59
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1800 TCKAAQMEVSVSKCKLFQLGFEREGVRINDRQCSGV---EGEDFISFQINNTKgnCGNIVQSNSTHIVYKNTIWIesANN 1876
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQftdATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1877 TGNVITRDRTISVEFSCAYELDLKISLDSVVKPMLSVINltVPTQEGSFITKMALYKNASYKHPYRQGEVVLttRDVLYV 1956
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1957 GVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEGGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2034
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1926259031  2035 CAVSLCDSEKYS--CKINCPQN 2054
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
1801-2052 3.06e-53

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 187.81  E-value: 3.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1801 CKAAQMEVSVSKCKLFQLGFEREGVR--INDRQCSGV---EGEDFISFQINNTkgNCGNIVQSNSTHIVYKNTIWIESAN 1875
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPVsntNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1876 NtGNVITRDRTISVEFSCAYELDLKISLDSVVKPmlsVINLTVPTQEGSFITKMALYKNASYKHPYRQGEVVLTTRDVLY 1955
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPP---SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1956 VGVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIG--IEENGVSLTCRFHVTVFKFIGDY-DEVH 2032
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1926259031 2033 LHCAVSLCDSEKYSCKINCP 2052
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 9.83e-46

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 162.54  E-value: 9.83e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1926259031  402 VNDLVTSLPVTLDLGAVKIYQSGM-STAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 1.19e-45

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 162.57  E-value: 1.19e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   313 YCSPVET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   392 IPKGsYGKVKVNDLVTSLPVTLDLGAVKIYQSGMSTAVETDFGLL-VTFDGQHYASISIPGSYINSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1926259031   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 163-251 7.65e-39

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 140.12  E-value: 7.65e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  163 VNTFQAVLVSDGSYTFTLFNY--YEINWTTGTASGGdpLTGLGGVMAQAGFNGGN-LTNFFSLPGSRTPDIVNIQETTNV 239
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYpdGGIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1926259031  240 NVPGRWAFKVDG 251
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 1.82e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.66  E-value: 1.82e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTgnrPSSDTFPKFIVTATNEDRDpSLALWVKQVDVTVFGYSLVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD---CSEEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTYLSITVPRSMRNSTYGLCGRYNGNPDDDLEMPMGV 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1090-1257 2.78e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 138.69  E-value: 2.78e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1090 YYC-QARTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTgnrpsSDTFPKFIVTATNEDRDPSLAlWVKQVDVTVFGY 1168
Cdd:smart00216    1 WCCtQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQD-----CSSEPTFSVLLKNVPCGGGAT-CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1169 SLVIHRAyKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVV-YDWKTYLSITVPRSMRNSTYGLCGRYNGN 1247
Cdd:smart00216   75 EIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1926259031  1248 PDDDLEMPMG 1257
Cdd:smart00216  154 PEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 3.69e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.41  E-value: 3.69e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1487 CLAAGSGVFRTFDGAFLRFPANCAFVLSTICQKLPTISFQLIINFDRWSSPNlTVISPVYFYINEEQILISDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926259031 1567 TQVNVPFIT-GLATKIYSrEGFLVIDTSPD--IQIHYNGFNVIKISIGERLQNKVCGLCGNFNGDLTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILG-SGFVVVDLSPGvgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1477-1638 1.20e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 125.21  E-value: 1.20e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1477 RGCFSTRT-SYCLAAGSGVFRTFDGAFLRFPANCAFVLSTICQKLPTISfqliINFDRWS-SPNLTVISPVYFYINEEQI 1554
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFS----VLLKNVPcGGGATCLKSVKVELNGDEI 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1555 LI-SDRNTVKVNGTQVNVPFITGLAT-KIYSREGFLVIDTSPDI-QIHYNGFNVIKISIGERLQNKVCGLCGNFNGDLTD 1631
Cdd:smart00216   77 ELkDDNGKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1926259031  1632 DYVTLRG 1638
Cdd:smart00216  157 DFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 1.59e-31

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.13  E-value: 1.59e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   703 QGCFPKR-QTVCLLSQNQVLHTFDGAAYTFPSDFSYTLLKTCPERPEYlEIDISKKKPEAGPTWLRGLRILVANQEVKIG 781
Cdd:smart00216    1 WCCTQEEcSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   782 GVGAsEVKLNGQEVELPFFHPLGKLEIYRNKNSTTVE-SKGIVSVQYSDVGLLYIRLSTAYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDNG-KVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1926259031   861 CLPTG 865
Cdd:smart00216  159 RTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 3.36e-31

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 120.94  E-value: 3.36e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  713 CLLSQNQVLHTFDGAAYTFPSDFSYTLLKTCPERPEYLEIDISKKKPEAGP-TWLRGLRILVANQEVKIGGVGasEVKLN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASgVCLKSVTVIVGDLEITLQKGG--TVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926259031  792 GQEVELPFFHPLGKLEIYRNKNSTTVESKGI-VSVQYSDVGLLYIRLSTAYFNCTGGLCGFFNANASDEFCLPTGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 5.88e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 97.03  E-value: 5.88e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031   517 LYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRVQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 523-591 7.05e-18

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 79.73  E-value: 7.05e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031  523 YCGFLNKtDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRVQTGC 591
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 2.00e-17

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 78.54  E-value: 2.00e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926259031   905 FYRSRARCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNQSELCDSVARYASTCKNADVQVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 7.32e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 7.32e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031 1300 LCGLIpSVNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNDTSC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 911-980 1.38e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 75.88  E-value: 1.38e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  911 RCGIINDpsNSSFLECHGVVNVTAYYRTCLFRLCQSGGNQSELCDSVARYASTCKNADVQVGPWRTYDFC 980
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1298-1368 2.45e-15

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 72.76  E-value: 2.45e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1926259031  1298 QQLCGLIPSVNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNDTSC 1368
Cdd:smart00832    5 CSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 3.59e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.58  E-value: 3.59e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  597 CPSFSHYSVCTSSCPNTCSDLTASRNCAAPCTEGCECDDGFVLSTS-QCVPLHKC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 9.53e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 70.11  E-value: 9.53e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  597 CPSFSHYSVCTSSCPNTCSDLTASRNCAAPCTEGCECDDGFVLS-TSQCVPLHKC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 2.06e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 69.27  E-value: 2.06e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHSC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1372-1425 3.63e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 68.57  E-value: 3.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHSC 1425
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 1.16e-12

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 64.26  E-value: 1.16e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  984 CPENSHFEECM-MCTVTCETLALGPVCVDSCSEGCQCDEGYAL-QGSQCVTRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGsACPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1679-1752 9.78e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 59.66  E-value: 9.78e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  1679 KMQGDGYCTKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YNHRKFQLCGSLAAYGESCRSFGVLSTEWIEKENC 1752
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 984-1036 1.47e-10

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 58.55  E-value: 1.47e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  984 CPENSHFEECMM-CTVTCETLALGPVCVDSCSEGCQCDEGYALQ-GSQCVTRSEC 1036
Cdd:pfam01826    1 CPANEVYSECGSaCPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1685-1752 2.70e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 52.38  E-value: 2.70e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031 1685 YCTKLTDmKGFFQPCYGLLDPLPFYESCYLDGC-YNHRKFQLCGSLAAYGESCRSFGVLSTEWIEKENC 1752
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2084-2116 4.00e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1926259031 2084 EDNGGCEQICTSRVEGPLCSCVTG-TLQEDGRSC 2116
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 652-706 7.49e-04

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 39.21  E-value: 7.49e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  652 CDFDGHYYTMGEFfWATANCTVQCLCEeGGDVYCFNKTCRSGEACAVEDGYQGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 1.11e-66

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 222.30  E-value: 1.11e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031    98 PFWADVHNGIRGEIYYRETTDPVILKRATKDVRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926259031   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1800-2054 2.01e-59

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 205.70  E-value: 2.01e-59
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1800 TCKAAQMEVSVSKCKLFQLGFEREGVRINDRQCSGV---EGEDFISFQINNTKgnCGNIVQSNSTHIVYKNTIWIesANN 1876
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQftdATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1877 TGNVITRDRTISVEFSCAYELDLKISLDSVVKPMLSVINltVPTQEGSFITKMALYKNASYKHPYRQGEVVLttRDVLYV 1956
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1957 GVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEGGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2034
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1926259031  2035 CAVSLCDSEKYS--CKINCPQN 2054
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
1801-2052 3.06e-53

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 187.81  E-value: 3.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1801 CKAAQMEVSVSKCKLFQLGFEREGVR--INDRQCSGV---EGEDFISFQINNTkgNCGNIVQSNSTHIVYKNTIWIESAN 1875
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPVsntNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1876 NtGNVITRDRTISVEFSCAYELDLKISLDSVVKPmlsVINLTVPTQEGSFITKMALYKNASYKHPYRQGEVVLTTRDVLY 1955
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPP---SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1956 VGVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEGGCQNIKDNTIG--IEENGVSLTCRFHVTVFKFIGDY-DEVH 2032
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1926259031 2033 LHCAVSLCDSEKYSCKINCP 2052
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 9.83e-46

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 162.54  E-value: 9.83e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1926259031  402 VNDLVTSLPVTLDLGAVKIYQSGM-STAVETDFGLLVTFDGQHYASISIPGSYINSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 1.19e-45

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 162.57  E-value: 1.19e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   313 YCSPVET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   392 IPKGsYGKVKVNDLVTSLPVTLDLGAVKIYQSGMSTAVETDFGLL-VTFDGQHYASISIPGSYINSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1926259031   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 163-251 7.65e-39

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 140.12  E-value: 7.65e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  163 VNTFQAVLVSDGSYTFTLFNY--YEINWTTGTASGGdpLTGLGGVMAQAGFNGGN-LTNFFSLPGSRTPDIVNIQETTNV 239
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYpdGGIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1926259031  240 NVPGRWAFKVDG 251
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 1.82e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.66  E-value: 1.82e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTgnrPSSDTFPKFIVTATNEDRDpSLALWVKQVDVTVFGYSLVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD---CSEEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTYLSITVPRSMRNSTYGLCGRYNGNPDDDLEMPMGV 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1090-1257 2.78e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 138.69  E-value: 2.78e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1090 YYC-QARTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTTgnrpsSDTFPKFIVTATNEDRDPSLAlWVKQVDVTVFGY 1168
Cdd:smart00216    1 WCCtQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQD-----CSSEPTFSVLLKNVPCGGGAT-CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1169 SLVIHRAyKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVV-YDWKTYLSITVPRSMRNSTYGLCGRYNGN 1247
Cdd:smart00216   75 EIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1926259031  1248 PDDDLEMPMG 1257
Cdd:smart00216  154 PEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 3.69e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.41  E-value: 3.69e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031 1487 CLAAGSGVFRTFDGAFLRFPANCAFVLSTICQKLPTISFQLIINFDRWSSPNlTVISPVYFYINEEQILISDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926259031 1567 TQVNVPFIT-GLATKIYSrEGFLVIDTSPD--IQIHYNGFNVIKISIGERLQNKVCGLCGNFNGDLTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILG-SGFVVVDLSPGvgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1477-1638 1.20e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 125.21  E-value: 1.20e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1477 RGCFSTRT-SYCLAAGSGVFRTFDGAFLRFPANCAFVLSTICQKLPTISfqliINFDRWS-SPNLTVISPVYFYINEEQI 1554
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFS----VLLKNVPcGGGATCLKSVKVELNGDEI 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  1555 LI-SDRNTVKVNGTQVNVPFITGLAT-KIYSREGFLVIDTSPDI-QIHYNGFNVIKISIGERLQNKVCGLCGNFNGDLTD 1631
Cdd:smart00216   77 ELkDDNGKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1926259031  1632 DYVTLRG 1638
Cdd:smart00216  157 DFRTPDG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 1.59e-31

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.13  E-value: 1.59e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   703 QGCFPKR-QTVCLLSQNQVLHTFDGAAYTFPSDFSYTLLKTCPERPEYlEIDISKKKPEAGPTWLRGLRILVANQEVKIG 781
Cdd:smart00216    1 WCCTQEEcSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031   782 GVGAsEVKLNGQEVELPFFHPLGKLEIYRNKNSTTVE-SKGIVSVQYSDVGLLYIRLSTAYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDNG-KVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1926259031   861 CLPTG 865
Cdd:smart00216  159 RTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 3.36e-31

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 120.94  E-value: 3.36e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  713 CLLSQNQVLHTFDGAAYTFPSDFSYTLLKTCPERPEYLEIDISKKKPEAGP-TWLRGLRILVANQEVKIGGVGasEVKLN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASgVCLKSVTVIVGDLEITLQKGG--TVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926259031  792 GQEVELPFFHPLGKLEIYRNKNSTTVESKGI-VSVQYSDVGLLYIRLSTAYFNCTGGLCGFFNANASDEFCLPTGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 5.88e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 97.03  E-value: 5.88e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031   517 LYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRVQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 523-591 7.05e-18

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 79.73  E-value: 7.05e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031  523 YCGFLNKtDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRVQTGC 591
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 2.00e-17

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 78.54  E-value: 2.00e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926259031   905 FYRSRARCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNQSELCDSVARYASTCKNADVQVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 7.32e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 7.32e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031 1300 LCGLIpSVNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNDTSC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 911-980 1.38e-16

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 75.88  E-value: 1.38e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926259031  911 RCGIINDpsNSSFLECHGVVNVTAYYRTCLFRLCQSGGNQSELCDSVARYASTCKNADVQVGPWRTYDFC 980
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1298-1368 2.45e-15

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 72.76  E-value: 2.45e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1926259031  1298 QQLCGLIPSVNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNDTSC 1368
Cdd:smart00832    5 CSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 3.59e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.58  E-value: 3.59e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  597 CPSFSHYSVCTSSCPNTCSDLTASRNCAAPCTEGCECDDGFVLSTS-QCVPLHKC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 9.53e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 70.11  E-value: 9.53e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  597 CPSFSHYSVCTSSCPNTCSDLTASRNCAAPCTEGCECDDGFVLS-TSQCVPLHKC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 2.06e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 69.27  E-value: 2.06e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHSC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1372-1425 3.63e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 68.57  E-value: 3.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLN-GKSCILPHSC 1425
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 1.16e-12

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 64.26  E-value: 1.16e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  984 CPENSHFEECM-MCTVTCETLALGPVCVDSCSEGCQCDEGYAL-QGSQCVTRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGsACPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1679-1752 9.78e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 59.66  E-value: 9.78e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  1679 KMQGDGYCTKLTDMKGFFQPCYGLLDPLPFYESCYLDGC-YNHRKFQLCGSLAAYGESCRSFGVLSTEWIEKENC 1752
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCaCGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 984-1036 1.47e-10

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 58.55  E-value: 1.47e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  984 CPENSHFEECMM-CTVTCETLALGPVCVDSCSEGCQCDEGYALQ-GSQCVTRSEC 1036
Cdd:pfam01826    1 CPANEVYSECGSaCPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1685-1752 2.70e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 52.38  E-value: 2.70e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926259031 1685 YCTKLTDmKGFFQPCYGLLDPLPFYESCYLDGC-YNHRKFQLCGSLAAYGESCRSFGVLSTEWIEKENC 1752
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2084-2116 4.00e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1926259031 2084 EDNGGCEQICTSRVEGPLCSCVTG-TLQEDGRSC 2116
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 652-706 7.49e-04

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 39.21  E-value: 7.49e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1926259031  652 CDFDGHYYTMGEFfWATANCTVQCLCEeGGDVYCFNKTCRSGEACAVEDGYQGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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