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Conserved domains on  [gi|1041065692|ref|XP_017292361|]
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alpha-sarcoglycan isoform X1 [Kryptolebias marmoratus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sarcoglycan_2 super family cl23856
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
31-377 1.91e-50

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


The actual alignment was detected with superfamily member pfam05510:

Pssm-ID: 461668  Cd Length: 410  Bit Score: 174.78  E-value: 1.91e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692  31 VGRLFTYELLRETFQNDFEPLTklygpvghlydDPMTFKCNEQGFPDLPEWLRFIQRHPLDNGFLYGTPT--SLGKN-II 107
Cdd:pfam05510  28 VGELFTYKIEPELFNWTHEVIS-----------EQFTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPaeNAGKPlII 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 108 EIYAVNKRSYDTTRQILVIKAVPEKMLPYQAEFFIQKREVERVLPPSVQNEIKQDLQY-LW--STQDLEIVNITNALDRG 184
Cdd:pfam05510  97 EIIALNRQNYETRRLIINMMVAHKFPTPNVIQMKIDNLNWVHMMDPGRVENLRNIFRKdLWppSREDLSIIFMESAVNMG 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 185 GRVPLPLAgHYEGVYVKVGSETFFSKCLESVWTTVHQKQCAAGSKGKAPEGCHFCRIPSNCITWCKTELFNLA------- 257
Cdd:pfam05510 177 GRLPLRPQ-QREGVIVHVGSDAQFSSRLRELQEEVRPLYKLPSCTYKRTSVQKIFENVGFKLDWCAFRLVGSEspteily 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 258 -----KQKPEPPAPTVGSGVLEAGGDFN----PPESPPSRDFFPDYMVTVIVPLVLAIVLCLLLAYIMFGRREG------ 322
Cdd:pfam05510 256 hsgkqKQVQTPQEVIRGHGILPDGGEERwmgpPREDVPERNYIDEFAIAFAIPGMIFAILFGILSAILCFQHEKfydphs 335
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1041065692 323 ---------------------VAKRNAKTDNIQLYHHH-TVHENAEELRSMAanrgvPPPLSTLPMFNSRTGERASP 377
Cdd:pfam05510 336 eyffanifhiceescamsessVEKRNMQTSTVQMVHCSdIQAQSTTTLKSLK-----DPPFLLDNYDSTNMSMRSQS 407
 
Name Accession Description Interval E-value
Sarcoglycan_2 pfam05510
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
31-377 1.91e-50

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


Pssm-ID: 461668  Cd Length: 410  Bit Score: 174.78  E-value: 1.91e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692  31 VGRLFTYELLRETFQNDFEPLTklygpvghlydDPMTFKCNEQGFPDLPEWLRFIQRHPLDNGFLYGTPT--SLGKN-II 107
Cdd:pfam05510  28 VGELFTYKIEPELFNWTHEVIS-----------EQFTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPaeNAGKPlII 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 108 EIYAVNKRSYDTTRQILVIKAVPEKMLPYQAEFFIQKREVERVLPPSVQNEIKQDLQY-LW--STQDLEIVNITNALDRG 184
Cdd:pfam05510  97 EIIALNRQNYETRRLIINMMVAHKFPTPNVIQMKIDNLNWVHMMDPGRVENLRNIFRKdLWppSREDLSIIFMESAVNMG 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 185 GRVPLPLAgHYEGVYVKVGSETFFSKCLESVWTTVHQKQCAAGSKGKAPEGCHFCRIPSNCITWCKTELFNLA------- 257
Cdd:pfam05510 177 GRLPLRPQ-QREGVIVHVGSDAQFSSRLRELQEEVRPLYKLPSCTYKRTSVQKIFENVGFKLDWCAFRLVGSEspteily 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 258 -----KQKPEPPAPTVGSGVLEAGGDFN----PPESPPSRDFFPDYMVTVIVPLVLAIVLCLLLAYIMFGRREG------ 322
Cdd:pfam05510 256 hsgkqKQVQTPQEVIRGHGILPDGGEERwmgpPREDVPERNYIDEFAIAFAIPGMIFAILFGILSAILCFQHEKfydphs 335
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1041065692 323 ---------------------VAKRNAKTDNIQLYHHH-TVHENAEELRSMAanrgvPPPLSTLPMFNSRTGERASP 377
Cdd:pfam05510 336 eyffanifhiceescamsessVEKRNMQTSTVQMVHCSdIQAQSTTTLKSLK-----DPPFLLDNYDSTNMSMRSQS 407
Dystroglycan_repeat cd11303
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ...
30-135 6.56e-13

Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand.


Pssm-ID: 206636 [Multi-domain]  Cd Length: 99  Bit Score: 64.30  E-value: 6.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692  30 PVGRLFTYELLRETFqndfepltklygpvghlYDDPMTFKCNEQGFPDLPEWLRFIQRhpldNGFLYGTPTS--LGKNII 107
Cdd:cd11303    12 VVGRLFTYKIPPDTF-----------------SGNGDTYQVSEAGKDDLPSWLQFDSS----SRTLYGLPLSddVGVHYI 70
                          90       100
                  ....*....|....*....|....*....
gi 1041065692 108 EIYAVNKRSY-DTTRQILVIKAVPEKMLP 135
Cdd:cd11303    71 SVTAEDKGSAgSQASDVFSIDVHPEPHPE 99
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
23-126 9.12e-07

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 46.95  E-value: 9.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692   23 AEIKFTTPVGRLFTYELLRETFqndfepltklYGPVGhlydDPMTFKCNEQGFPDLPEWLRFIQrhplDNGFLYGTPTS- 101
Cdd:smart00736   3 AIGDQTATEGESFSYTIPSSTF----------TDADG----DTLTYSATLSDGSALPSWLSFDS----DTGTLSGTPTNs 64
                           90       100
                   ....*....|....*....|....*.
gi 1041065692  102 -LGKNIIEIYAVNkRSYDTTRQILVI 126
Cdd:smart00736  65 dVGSLSLKVTATD-SSGASASDTFTI 89
 
Name Accession Description Interval E-value
Sarcoglycan_2 pfam05510
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
31-377 1.91e-50

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


Pssm-ID: 461668  Cd Length: 410  Bit Score: 174.78  E-value: 1.91e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692  31 VGRLFTYELLRETFQNDFEPLTklygpvghlydDPMTFKCNEQGFPDLPEWLRFIQRHPLDNGFLYGTPT--SLGKN-II 107
Cdd:pfam05510  28 VGELFTYKIEPELFNWTHEVIS-----------EQFTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPaeNAGKPlII 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 108 EIYAVNKRSYDTTRQILVIKAVPEKMLPYQAEFFIQKREVERVLPPSVQNEIKQDLQY-LW--STQDLEIVNITNALDRG 184
Cdd:pfam05510  97 EIIALNRQNYETRRLIINMMVAHKFPTPNVIQMKIDNLNWVHMMDPGRVENLRNIFRKdLWppSREDLSIIFMESAVNMG 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 185 GRVPLPLAgHYEGVYVKVGSETFFSKCLESVWTTVHQKQCAAGSKGKAPEGCHFCRIPSNCITWCKTELFNLA------- 257
Cdd:pfam05510 177 GRLPLRPQ-QREGVIVHVGSDAQFSSRLRELQEEVRPLYKLPSCTYKRTSVQKIFENVGFKLDWCAFRLVGSEspteily 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692 258 -----KQKPEPPAPTVGSGVLEAGGDFN----PPESPPSRDFFPDYMVTVIVPLVLAIVLCLLLAYIMFGRREG------ 322
Cdd:pfam05510 256 hsgkqKQVQTPQEVIRGHGILPDGGEERwmgpPREDVPERNYIDEFAIAFAIPGMIFAILFGILSAILCFQHEKfydphs 335
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1041065692 323 ---------------------VAKRNAKTDNIQLYHHH-TVHENAEELRSMAanrgvPPPLSTLPMFNSRTGERASP 377
Cdd:pfam05510 336 eyffanifhiceescamsessVEKRNMQTSTVQMVHCSdIQAQSTTTLKSLK-----DPPFLLDNYDSTNMSMRSQS 407
Dystroglycan_repeat cd11303
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ...
30-135 6.56e-13

Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand.


Pssm-ID: 206636 [Multi-domain]  Cd Length: 99  Bit Score: 64.30  E-value: 6.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692  30 PVGRLFTYELLRETFqndfepltklygpvghlYDDPMTFKCNEQGFPDLPEWLRFIQRhpldNGFLYGTPTS--LGKNII 107
Cdd:cd11303    12 VVGRLFTYKIPPDTF-----------------SGNGDTYQVSEAGKDDLPSWLQFDSS----SRTLYGLPLSddVGVHYI 70
                          90       100
                  ....*....|....*....|....*....
gi 1041065692 108 EIYAVNKRSY-DTTRQILVIKAVPEKMLP 135
Cdd:cd11303    71 SVTAEDKGSAgSQASDVFSIDVHPEPHPE 99
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
23-126 9.12e-07

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 46.95  E-value: 9.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041065692   23 AEIKFTTPVGRLFTYELLRETFqndfepltklYGPVGhlydDPMTFKCNEQGFPDLPEWLRFIQrhplDNGFLYGTPTS- 101
Cdd:smart00736   3 AIGDQTATEGESFSYTIPSSTF----------TDADG----DTLTYSATLSDGSALPSWLSFDS----DTGTLSGTPTNs 64
                           90       100
                   ....*....|....*....|....*.
gi 1041065692  102 -LGKNIIEIYAVNkRSYDTTRQILVI 126
Cdd:smart00736  65 dVGSLSLKVTATD-SSGASASDTFTI 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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