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Conserved domains on  [gi|1034576106|ref|XP_016874001|]
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polycomb protein EED isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-398 7.70e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 7.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 298
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 299 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 370
Cdd:cd00200   164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                         250       260
                  ....*....|....*....|....*...
gi 1034576106 371 dFWQKMLALGNQVGKLYVWDLEVEDPHK 398
Cdd:cd00200   229 -PDGYLLASGSEDGTIRVWDLRTGECVQ 255
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-398 7.70e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 7.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 298
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 299 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 370
Cdd:cd00200   164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                         250       260
                  ....*....|....*....|....*...
gi 1034576106 371 dFWQKMLALGNQVGKLYVWDLEVEDPHK 398
Cdd:cd00200   229 -PDGYLLASGSEDGTIRVWDLRTGECVQ 255
WD40 COG2319
WD40 repeat [General function prediction only];
162-392 2.55e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD------YNPNktNRPFIS----QKIHFPDFSTRDI------H 305
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvnsvaFSPD--GKLLASgsddGTVRLWDLATGKLlrtltgH 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 306 RNYVDCVRW--LGDLILSKSCENAIVCWkpgkmedDIDkikpsesNVTILGRFDYSQCDIWYMRFSMDfwQKMLALGNQV 383
Cdd:COG2319   330 TGAVRSVAFspDGKTLASGSDDGTVRLW-------DLA-------TGELLRTLTGHTGAVTSVAFSPD--GRTLASGSAD 393


                  ....*....
gi 1034576106 384 GKLYVWDLE 392
Cdd:COG2319   394 GTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 3.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.39e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034576106  179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 1.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034576106 180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 167-269 1.69e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 167 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 241
Cdd:PTZ00420   51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034576106 242 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 269
Cdd:PTZ00420  131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-398 7.70e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 7.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200    15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 298
Cdd:cd00200    90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 299 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 370
Cdd:cd00200   164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                         250       260
                  ....*....|....*....|....*...
gi 1034576106 371 dFWQKMLALGNQVGKLYVWDLEVEDPHK 398
Cdd:cd00200   229 -PDGYLLASGSEDGTIRVWDLRTGECVQ 255
WD40 COG2319
WD40 repeat [General function prediction only];
162-392 2.55e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD------YNPNktNRPFIS----QKIHFPDFSTRDI------H 305
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvnsvaFSPD--GKLLASgsddGTVRLWDLATGKLlrtltgH 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 306 RNYVDCVRW--LGDLILSKSCENAIVCWkpgkmedDIDkikpsesNVTILGRFDYSQCDIWYMRFSMDfwQKMLALGNQV 383
Cdd:COG2319   330 TGAVRSVAFspDGKTLASGSDDGTVRLW-------DLA-------TGELLRTLTGHTGAVTSVAFSPD--GRTLASGSAD 393


                  ....*....
gi 1034576106 384 GKLYVWDLE 392
Cdd:COG2319   394 GTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
83-269 7.73e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 7.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106  83 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNTshpl 162
Cdd:COG2319   195 KLLRTLT-GHTGAVRSVAF---SPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGH-----SGSVRSVAFSPDGRL---- 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 242
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSV 336

                         170       180
                  ....*....|....*....|....*..
gi 1034576106 243 DYDLLGEKIMSCGMDHSLKLWRINSKR 269
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-264 2.91e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106  81 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 158
Cdd:cd00200   124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 159 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 238
Cdd:cd00200   192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263

                         170       180
                  ....*....|....*....|....*.
gi 1034576106 239 VLSADYDLLGEKIMSCGMDHSLKLWR 264
Cdd:cd00200   264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-267 1.95e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 1.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106  83 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshpl 162
Cdd:COG2319   237 KLLRTLT-GHSGSVRSVAF---SPDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-----VNSVAFSPDGKL---- 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 242
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSV 378

                         170       180
                  ....*....|....*....|....*
gi 1034576106 243 DYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319   379 AFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-331 9.39e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 9.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 148 YTCAWtydsNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVA 227
Cdd:cd00200    97 SSVAF----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 228 IFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNaikesydynpnktnrpfisqkihfpdfsTRDIHRN 307
Cdd:cd00200   172 TL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG----------------------------TLRGHEN 220

                         170       180
                  ....*....|....*....|....*.
gi 1034576106 308 YVDCVRWL--GDLILSKSCENAIVCW 331
Cdd:cd00200   221 GVNSVAFSpdGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
162-392 3.82e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 3.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTL---TGHSGAVTS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD------YNPNktNRPFIS----QKIHFPDFSTRDI------H 305
Cdd:COG2319   168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavrsvaFSPD--GKLLASgsadGTVRLWDLATGKLlrtltgH 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 306 RNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQV 383
Cdd:COG2319   246 SGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL-------LRTLTGHSGGVNSVAFSPD--GKLLASGSDD 309


                  ....*....
gi 1034576106 384 GKLYVWDLE 392
Cdd:COG2319   310 GTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-276 1.58e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 1.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106  81 SFKCVNSLkEDHNQPLFGVQFNWHskegDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWtydsNTSH 160
Cdd:cd00200    82 TGECVRTL-TGHTSYVSSVAFSPD----GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-----VNSVAF----SPDG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 161 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVL 240
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTL---RGHENGVN 223

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1034576106 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276
Cdd:cd00200   224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
162-392 1.97e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE------SYDYNPNktNRPFIS----QKIHFPDFSTRDI------H 305
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhsgavtSVAFSPD--GKLLASgsddGTVRLWDLATGKLlrtltgH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 306 RNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKPsesnVTILGRFDYSqcdIWYMRFSMDfwQKMLALGNQV 383
Cdd:COG2319   204 TGAVRSVAFSpdGKLLASGSADGTVRLW-------DLATGKL----LRTLTGHSGS---VRSVAFSPD--GRLLASGSAD 267


                  ....*....
gi 1034576106 384 GKLYVWDLE 392
Cdd:COG2319   268 GTVRLWDLA 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 3.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.39e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034576106  179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 1.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034576106 180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 167-269 1.69e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 167 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 241
Cdd:PTZ00420   51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034576106 242 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 269
Cdd:PTZ00420  131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
PTZ00421 PTZ00421
coronin; Provisional
 183-262 6.70e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.72  E-value: 6.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIfggVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262
Cdd:PTZ00421  118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-263 7.76e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 7.76e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034576106  233 EGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-403 9.91e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 9.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINskrmmnaikesydynpnkTNRPFISQKIHfpdfsTRDIHRnyVDC 311
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE------------------TGELLRTLKGH-----TGPVRD--VAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576106 312 VRWlGDLILSKSCENAIVCWKPGKmeddidkikpSESNVTILGrfdySQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDL 391
Cdd:cd00200    60 SAD-GTYLASGSSDKTIRLWDLET----------GECVRTLTG----HTSYVSSVAFSPD--GRILSSSSRDKTIKVWDV 122

                         170
                  ....*....|..
gi 1034576106 392 EVEDPHKANRDH 403
Cdd:cd00200   123 ETGKCLTTLRGH 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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