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Conserved domains on  [gi|1034646532|ref|XP_016865477|]
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multiple epidermal growth factor-like domains protein 10 isoform X3 [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 229591)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779
SCOP:  4003198

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 162-207 1.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 36.95  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034646532 162 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 207
Cdd:pfam00053   1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 162-207 1.90e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034646532 162 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 207
Cdd:pfam00053   1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 162-207 1.90e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034646532 162 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 207
Cdd:pfam00053   1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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