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Conserved domains on  [gi|1034641149|ref|XP_016864100|]
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putative methyltransferase NSUN7 isoform X1 [Homo sapiens]

Protein Classification

RsmB family protein( domain architecture ID 1002937)

RsmB family protein such as 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB, which specifically methylates cytosine(967) at C(5) in 16S rRNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RsmB super family cl33775
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
366-441 7.78e-09

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


The actual alignment was detected with superfamily member COG0144:

Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 58.48  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 366 LAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKAL----EFQDLgnkgqPYRLSPPVLPLCSLKEIQL----- 435
Cdd:COG0144   353 LAALQRELLDAAARLLKPGGRlVYSTCSLLPEENEEVVEAFLarhpDFELV-----PLAELLPGLALTDGGYLRLlphrh 427

                  ....*.
gi 1034641149 436 STDKFF 441
Cdd:COG0144   428 GTDGFF 433
PRK14902 super family cl36439
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
208-407 4.24e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


The actual alignment was detected with superfamily member PRK14902:

Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 49.79  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 208 INTCKISPEEVYNNLKRRGYNKVKSV-----LHIDDKvfavdqhcydvlifpshlknDLINIDLFKDYKLIFQDKSRSLA 282
Cdd:PRK14902  183 VNTLKISVEELIEKLEEEGYEVEESLlspeaLVIEKG--------------------NIAGTDLFKDGLITIQDESSMLV 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 283 VHSVKalLNMDDDVL----------------MVNTGSWYTV---SHMSILTNNNTSKVFVCGVQSQAKD-----PDLKTL 338
Cdd:PRK14902  243 APALD--PKGGDTVLdacaapggktthiaelLKNTGKVVALdihEHKLKLIEENAKRLGLTNIETKALDarkvhEKFAEK 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 339 FTKIgckntefLKDHSQGGISV-------------DKLHVLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKK 404
Cdd:PRK14902  321 FDKI-------LVDAPCSGLGVirrkpdikynktkEDIESLQEIQLEILESVAQYLKKGGIlVYSTCTIEKEENEEVIEA 393

                  ...
gi 1034641149 405 ALE 407
Cdd:PRK14902  394 FLE 396
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
366-441 7.78e-09

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 58.48  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 366 LAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKAL----EFQDLgnkgqPYRLSPPVLPLCSLKEIQL----- 435
Cdd:COG0144   353 LAALQRELLDAAARLLKPGGRlVYSTCSLLPEENEEVVEAFLarhpDFELV-----PLAELLPGLALTDGGYLRLlphrh 427

                  ....*.
gi 1034641149 436 STDKFF 441
Cdd:COG0144   428 GTDGFF 433
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
208-407 4.24e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 49.79  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 208 INTCKISPEEVYNNLKRRGYNKVKSV-----LHIDDKvfavdqhcydvlifpshlknDLINIDLFKDYKLIFQDKSRSLA 282
Cdd:PRK14902  183 VNTLKISVEELIEKLEEEGYEVEESLlspeaLVIEKG--------------------NIAGTDLFKDGLITIQDESSMLV 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 283 VHSVKalLNMDDDVL----------------MVNTGSWYTV---SHMSILTNNNTSKVFVCGVQSQAKD-----PDLKTL 338
Cdd:PRK14902  243 APALD--PKGGDTVLdacaapggktthiaelLKNTGKVVALdihEHKLKLIEENAKRLGLTNIETKALDarkvhEKFAEK 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 339 FTKIgckntefLKDHSQGGISV-------------DKLHVLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKK 404
Cdd:PRK14902  321 FDKI-------LVDAPCSGLGVirrkpdikynktkEDIESLQEIQLEILESVAQYLKKGGIlVYSTCTIEKEENEEVIEA 393

                  ...
gi 1034641149 405 ALE 407
Cdd:PRK14902  394 FLE 396
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
331-406 9.36e-06

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 47.03  E-value: 9.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034641149 331 KDPDLKTLFTKigcknteflKDHSQggisvdklhvLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKAL 406
Cdd:pfam01189  97 RHPDVKWLRQE---------ADIAQ----------LAQLQKELLSAAIDLLKPGGVlVYSTCSVLPEENEAVIEYFL 154
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
361-407 1.05e-04

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 45.31  E-value: 1.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034641149 361 DKLHVLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKALE 407
Cdd:PRK14901  354 EKIQELAPLQAELLESLAPLLKPGGTlVYATCTLHPAENEAQIEQFLA 401
 
Name Accession Description Interval E-value
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
366-441 7.78e-09

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 58.48  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 366 LAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKAL----EFQDLgnkgqPYRLSPPVLPLCSLKEIQL----- 435
Cdd:COG0144   353 LAALQRELLDAAARLLKPGGRlVYSTCSLLPEENEEVVEAFLarhpDFELV-----PLAELLPGLALTDGGYLRLlphrh 427

                  ....*.
gi 1034641149 436 STDKFF 441
Cdd:COG0144   428 GTDGFF 433
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
208-407 4.24e-06

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 49.79  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 208 INTCKISPEEVYNNLKRRGYNKVKSV-----LHIDDKvfavdqhcydvlifpshlknDLINIDLFKDYKLIFQDKSRSLA 282
Cdd:PRK14902  183 VNTLKISVEELIEKLEEEGYEVEESLlspeaLVIEKG--------------------NIAGTDLFKDGLITIQDESSMLV 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 283 VHSVKalLNMDDDVL----------------MVNTGSWYTV---SHMSILTNNNTSKVFVCGVQSQAKD-----PDLKTL 338
Cdd:PRK14902  243 APALD--PKGGDTVLdacaapggktthiaelLKNTGKVVALdihEHKLKLIEENAKRLGLTNIETKALDarkvhEKFAEK 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641149 339 FTKIgckntefLKDHSQGGISV-------------DKLHVLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKK 404
Cdd:PRK14902  321 FDKI-------LVDAPCSGLGVirrkpdikynktkEDIESLQEIQLEILESVAQYLKKGGIlVYSTCTIEKEENEEVIEA 393

                  ...
gi 1034641149 405 ALE 407
Cdd:PRK14902  394 FLE 396
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
331-406 9.36e-06

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 47.03  E-value: 9.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034641149 331 KDPDLKTLFTKigcknteflKDHSQggisvdklhvLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKAL 406
Cdd:pfam01189  97 RHPDVKWLRQE---------ADIAQ----------LAQLQKELLSAAIDLLKPGGVlVYSTCSVLPEENEAVIEYFL 154
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
361-407 1.05e-04

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 45.31  E-value: 1.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034641149 361 DKLHVLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKALE 407
Cdd:PRK14901  354 EKIQELAPLQAELLESLAPLLKPGGTlVYATCTLHPAENEAQIEQFLA 401
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
358-409 1.10e-04

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 45.05  E-value: 1.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034641149 358 ISVDKLHVLAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEEN----EAVVKKALEFQ 409
Cdd:PRK14904  344 LTPEKLAELVGLQAELLDHAASLLKPGGVlVYATCSIEPEENelqiEAFLQRHPEFS 400
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
366-407 3.39e-04

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 43.64  E-value: 3.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034641149 366 LAQQQYEQLTHAMKFTKAQAV-VYCTCSVFPEENEAVVKKALE 407
Cdd:PRK10901  347 LAALQSEILDALWPLLKPGGTlLYATCSILPEENEQQIKAFLA 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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