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Conserved domains on  [gi|1034631298|ref|XP_016861225|]
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ankyrin repeat and SOCS box protein 14 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
78-351 2.76e-44

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 159.35  E-value: 2.76e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  78 ADEIGWIPLHKAAVQLNRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAA 157
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 158 VLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLR 237
Cdd:COG0666    95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 238 KGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVT-DLAAIKQSGIS 316
Cdd:COG0666   175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGaDLNAKDKDGLT 254

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1034631298 317 PVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKH 351
Cdd:COG0666   255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 529-585 4.37e-38

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239700  Cd Length: 57  Bit Score: 134.20  E-value: 4.37e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631298 529 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 585
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
Ank_2 pfam12796
Ankyrin repeats (3 copies);
319-413 1.76e-09

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 319 HCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP-VNCLQIALRMG 397
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72

                          90
                  ....*....|....*.
gi 1034631298 398 NYELISLLLRHGANVN 413
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
78-351 2.76e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 159.35  E-value: 2.76e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  78 ADEIGWIPLHKAAVQLNRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAA 157
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 158 VLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLR 237
Cdd:COG0666    95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 238 KGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVT-DLAAIKQSGIS 316
Cdd:COG0666   175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGaDLNAKDKDGLT 254

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1034631298 317 PVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKH 351
Cdd:COG0666   255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 529-585 4.37e-38

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 134.20  E-value: 4.37e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631298 529 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 585
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 169-417 5.61e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 5.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 169 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT-----EIMEMLLRKGANAH 243
Cdd:PHA03100   21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVN 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 244 GQASDSSSILLEAASG--GNPDAVALLLEYGADANIPKNSGHLPIHVAAdRGHLLALKILipvtdlaaikqsgispvhca 321
Cdd:PHA03100  101 APDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYL-ESNKIDLKIL-------------------- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 322 aagahpqclELLIQAGFDVNFM--LDQRINKHYDDHRK-----SALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQ 391
Cdd:PHA03100  160 ---------KLLIDKGVDINAKnrVNYLLSYGVPINIKdvygfTPLHYAVYNNNPEFVKYLLDLGANPNlvnKYGDTPLH 230

                         250       260
                  ....*....|....*....|....*.
gi 1034631298 392 IALRMGNYELISLLLRHGANVNYFCR 417
Cdd:PHA03100  231 IAILNNNKEIFKLLLNNGPSIKTIIE 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
154-241 9.43e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 9.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 154 LLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLmLVSGAHPDPQsTYGFTPLALAAQSGHTEIME 233
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKL-LLEHADVNLK-DNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 1034631298 234 MLLRKGAN 241
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 530-571 3.42e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.95  E-value: 3.42e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVL 571
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGK---RRLGAIDKLPLPPLLKDYLL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
319-413 1.76e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 319 HCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP-VNCLQIALRMG 397
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72

                          90
                  ....*....|....*.
gi 1034631298 398 NYELISLLLRHGANVN 413
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 112-247 6.60e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.49  E-value: 6.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 112 QTTHNGETPLFLAVSSCLLENATFLLL-NGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGAD-VNLRCANE----RT 185
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgET 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034631298 186 ALHEAAKLGREDMVKLMLVSGA--------------HPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQAS 247
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGAdvvspratgtffrpGPKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 265-446 1.13e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.58  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 265 VALLLEYGADANI-PKNSGHLPIHVAADRghllalkiliPVTDLAaikqsgispvhcaaagahpqclELLIQAGFDVNFM 343
Cdd:PHA02878  150 TKLLLSYGADINMkDRHKGNTALHYATEN----------KDQRLT----------------------ELLLSYGANVNIP 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 344 ldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGAlpNQDPVNC-----LQIAL-RMGNYELISLLLRHGANVNYFCR 417
Cdd:PHA02878  198 ---------DKTNNSPLHHAVKHYNKPIVHILLENGA--STDARDKcgntpLHISVgYCKDYDILKLLLEHGVDVNAKSY 266

                         170       180
                  ....*....|....*....|....*....
gi 1034631298 418 VNPLhfpSALQYTLKDEVMLRMLLNYGYD 446
Cdd:PHA02878  267 ILGL---TALHSSIKSERKLKLLLEYGAD 292
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 532-573 1.60e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.48  E-value: 1.60e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034631298  532 RSLKHLCRLKIRKCMGrlhlrcpvFMSFLPLPNRLKAYVLYK 573
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 142-274 2.14e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.38  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 142 NPNAKNFEGNSPLLAAVLR-DCYDMAALLINYGADVnlrcANERTALHEAAKL---GREDMVKLMLVSGAHPDPQS---- 213
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIEnENLELTELLLNLSCRG----AVGDTLLHAISLEyvdAVEAILLHLLAAFRKSGPLEland 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 214 ------TYGFTPLALAAQSGHTEIMEMLLRKGANAH----------GQASD----SSSILLEAASGGNPDAVALLLEYGA 273
Cdd:TIGR00870 120 qytsefTPGITALHLAAHRQNYEIVKLLLERGASVParacgdffvkSQGVDsfyhGESPLNAAACLGSPSIVALLSEDPA 199


                  .
gi 1034631298 274 D 274
Cdd:TIGR00870 200 D 200
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 215-241 3.92e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.92e-04
                           10        20
                   ....*....|....*....|....*..
gi 1034631298  215 YGFTPLALAAQSGHTEIMEMLLRKGAN 241
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
78-351 2.76e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 159.35  E-value: 2.76e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  78 ADEIGWIPLHKAAVQLNRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAA 157
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 158 VLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLR 237
Cdd:COG0666    95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 238 KGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVT-DLAAIKQSGIS 316
Cdd:COG0666   175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGaDLNAKDKDGLT 254

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1034631298 317 PVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKH 351
Cdd:COG0666   255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-302 1.97e-43

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 157.04  E-value: 1.97e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  57 IEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITLSASDPSLwEQTTHNGETPLFLAVSSCLLENATFL 136
Cdd:COG0666    28 AALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI-NAKDDGGNTLLHAAARNGDLEIVKLL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 137 LLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYG 216
Cdd:COG0666   107 LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 217 FTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLL 296
Cdd:COG0666   187 ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266


                  ....*.
gi 1034631298 297 ALKILI 302
Cdd:COG0666   267 IVKLLL 272
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 529-585 4.37e-38

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 134.20  E-value: 4.37e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631298 529 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTG 585
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQGIFTG 57
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
130-414 1.48e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 1.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 130 LENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHP 209
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 210 DPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVA 289
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 290 ADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNSD 368
Cdd:COG0666   161 AANGNLEIVKLLLEAgADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN---------AKDNDGKTALDLAAENGN 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1034631298 369 LSSVKLLLSAGALPNQDPVNCLQ---IALRMGNYELISLLLRHGANVNY 414
Cdd:COG0666   232 LEIVKLLLEAGADLNAKDKDGLTallLAAAAGAALIVKLLLLALLLLAA 280
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 530-582 2.85e-18

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 78.72  E-value: 2.85e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGI 582
Cdd:cd03731     2 NPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQEL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 169-417 5.61e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 5.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 169 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT-----EIMEMLLRKGANAH 243
Cdd:PHA03100   21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVN 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 244 GQASDSSSILLEAASG--GNPDAVALLLEYGADANIPKNSGHLPIHVAAdRGHLLALKILipvtdlaaikqsgispvhca 321
Cdd:PHA03100  101 APDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYL-ESNKIDLKIL-------------------- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 322 aagahpqclELLIQAGFDVNFM--LDQRINKHYDDHRK-----SALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQ 391
Cdd:PHA03100  160 ---------KLLIDKGVDINAKnrVNYLLSYGVPINIKdvygfTPLHYAVYNNNPEFVKYLLDLGANPNlvnKYGDTPLH 230

                         250       260
                  ....*....|....*....|....*.
gi 1034631298 392 IALRMGNYELISLLLRHGANVNYFCR 417
Cdd:PHA03100  231 IAILNNNKEIFKLLLNNGPSIKTIIE 256
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 530-573 6.08e-17

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 74.45  E-value: 6.08e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 573
Cdd:cd03716     2 TPRSLQHLCRLAIRRCLGR---RRLELIKKLPLPPRLKDYLLYE 42
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 124-343 9.14e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 82.73  E-value: 9.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 124 AVSSCLLENATFLLLNGCNPNAKNFEGNSPL-LAAVLRDCyDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLM 202
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIkLAMKFRDS-EAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 203 LVSGAHPDpQSTY--GFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKN 280
Cdd:PHA02875   88 LDLGKFAD-DVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034631298 281 SGHLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAA-GAHPQCLELLIQAGFDVNFM 343
Cdd:PHA02875  167 CGCTPLIIAMAKGDIAICKMLLDSgANIDYFGKNGCVAALCYAIeNNKIDIVRLFIKRGADCNIM 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
154-241 9.43e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 9.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 154 LLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLmLVSGAHPDPQsTYGFTPLALAAQSGHTEIME 233
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKL-LLEHADVNLK-DNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 1034631298 234 MLLRKGAN 241
Cdd:pfam12796  79 LLLEKGAD 86
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 82-277 3.76e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 80.81  E-value: 3.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  82 GWIPLhKAAVQLnRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNF-EGNSPLLAAVLR 160
Cdd:PHA02875   35 GISPI-KLAMKF-RDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATIL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 161 DCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA 240
Cdd:PHA02875  113 KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034631298 241 NAH--GQASDsSSILLEAASGGNPDAVALLLEYGADANI 277
Cdd:PHA02875  193 NIDyfGKNGC-VAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 119-302 7.74e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.71  E-value: 7.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 119 TPLFLAVSSCLLENATFLLLNGCNPN--AKNFEGNSPLLA---AVLRDCYDMAALLINYGADVNLRCANERTALHEAA-- 191
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINssTKNNSTPLHYLSnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIsk 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 192 KLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH--TEIMEMLLRKGANAHgqASDSSSILLE-------------- 255
Cdd:PHA03100  117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDIN--AKNRVNYLLSygvpinikdvygft 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034631298 256 ----AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI 302
Cdd:PHA03100  195 plhyAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 530-573 5.82e-15

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 68.65  E-value: 5.82e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 573
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGK---RRLDLIDKLPLPPRLKDYLLYK 41
Ank_2 pfam12796
Ankyrin repeats (3 copies);
187-277 8.57e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 8.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 187 LHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLrkgANAHGQASDS-SSILLEAASGGNPDAV 265
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL---EHADVNLKDNgRTALHYAARSGHLEIV 77

                          90
                  ....*....|..
gi 1034631298 266 ALLLEYGADANI 277
Cdd:pfam12796  78 KLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 117-377 1.20e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.60  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 117 GETPL--FLAVSSCLLENATFLLLN-GCNPNAKNFEGNSPLLAAVLRDC-YDMAALLINYGADVNLRCANERTALHE--A 190
Cdd:PHA03095   47 GKTPLhlYLHYSSEKVKDIVRLLLEaGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVylS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 191 AKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT--EIMEMLLRKGANAHGQASDSSSILLEAASGGNPDA--VA 266
Cdd:PHA03095  127 GFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRAriVR 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 267 LLLEYGADANIPKNSGHLPIHVAADRGHLLALKI---LIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNfm 343
Cdd:PHA03095  207 ELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlplLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN-- 284

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1034631298 344 ldqrinkHYDDHRKSALYFAVSNSDLSSVKLLLS 377
Cdd:PHA03095  285 -------AVSSDGNTPLSLMVRNNNGRAVRAALA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
121-212 1.73e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 121 LFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYgADVNLRCaNERTALHEAAKLGREDMVK 200
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 1034631298 201 LMLVSGAHPDPQ 212
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 136-289 2.55e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 75.69  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 136 LLLNGCNPNAKN-FEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQST 214
Cdd:PHA02878  153 LLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034631298 215 YGFTPLALAAQS-GHTEIMEMLLRKGANAHGQasdsSSILLEAA---SGGNPDAVALLLEYGADANIPKNSGHLPIHVA 289
Cdd:PHA02878  233 CGNTPLHISVGYcKDYDILKLLLEHGVDVNAK----SYILGLTAlhsSIKSERKLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
253-341 6.19e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 6.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 253 LLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLaAIKQSGISPVHCAAAGAHPQCLEL 332
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV-NLKDNGRTALHYAARSGHLEIVKL 79


                  ....*....
gi 1034631298 333 LIQAGFDVN 341
Cdd:pfam12796  80 LLEKGADIN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 149-442 6.37e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 74.23  E-value: 6.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 149 EGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDpqstygftplALAAQSGH 228
Cdd:PHA02874   34 ETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS----------ILPIPCIE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 229 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLA 308
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 309 AIKQSGI-SPVHCAAAGAHPQCLELLIQAGFDVNfmldQRINKHYDDHRKSALYfavsnsDLSSVKLLLSAGALPNQDpV 387
Cdd:PHA02874  184 NVKDNNGeSPLHNAAEYGDYACIKLLIDHGNHIM----NKCKNGFTPLHNAIIH------NRSAIELLINNASINDQD-I 252

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034631298 388 NC---LQIALRMG-NYELISLLLRHGANVNyfCRVNPLHFP--SALQYTLKDEVMLRMLLN 442
Cdd:PHA02874  253 DGstpLHHAINPPcDIDIIDILLYHKADIS--IKDNKGENPidTAFKYINKDPVIKDIIAN 311
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 41-242 2.26e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 72.39  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  41 SLHSFLSADYKKIVETI-EKG---KEDALSHLTKYHSAFGEadeigwiplhKAAVQLNRKILEITLSASdpSLWEQTTHN 116
Cdd:PHA03100   38 PLYLAKEARNIDVVKILlDNGadiNSSTKNNSTPLHYLSNI----------KYNLTDVKEIVKLLLEYG--ANVNAPDNN 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 117 GETPLFLAVSSCL--LENATFLLLNGCNPNAKNFEGNSpLLAAVLRDCY---DMAALLI----------------NYGAD 175
Cdd:PHA03100  106 GITPLLYAISKKSnsYSIVEYLLDNGANVNIKNSDGEN-LLHLYLESNKidlKILKLLIdkgvdinaknrvnyllSYGVP 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631298 176 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANA 242
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA03095 PHA03095
ankyrin-like protein; Provisional
 168-426 3.12e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 3.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 168 LLINYGADVNLRCANERTALHEAAKLG---REDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTE-IMEMLLRKGA--N 241
Cdd:PHA03095   32 RLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGAdvN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 242 AHGQASDSssiLLEAASGG---NPDAVALLLEYGADANIPKNSGHLPIHVaadrghllalkilipvtdlaAIKQSGISpv 318
Cdd:PHA03095  112 AKDKVGRT---PLHVYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAV--------------------LLKSRNAN-- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 319 hcaaagahPQCLELLIQAGFDVnfmldqrINKhyDDHRKSAL-YFAVS-NSDLSSVKLLLSAGALPNQDPV--NCLQIAL 394
Cdd:PHA03095  167 --------VELLRLLIDAGADV-------YAV--DDRFRSLLhHHLQSfKPRARIVRELIRAGCDPAATDMlgNTPLHSM 229

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1034631298 395 RMGNYELISL---LLRHGANVNYFCRV--NPLHFPSA 426
Cdd:PHA03095  230 ATGSSCKRSLvlpLLIAGISINARNRYgqTPLHYAAV 266
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 182-447 3.13e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 182 NERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAaqsghteimeMLLRkganahgqasdsssilleaasggN 261
Cdd:PHA02875    1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLA----------MKFR-----------------------D 47

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 262 PDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLA--AIKQSGISPVHCAAAGAHPQCLELLIQAGFD 339
Cdd:PHA02875   48 SEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAddVFYKDGMTPLHLATILKKLDIMKLLIARGAD 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 340 VNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPN-QDPVNC--LQIALRMGNYELISLLLRHGANVNYFC 416
Cdd:PHA02875  128 PDIP---------NTDKFSPLHLAVMMGDIKGIELLIDHKACLDiEDCCGCtpLIIAMAKGDIAICKMLLDSGANIDYFG 198

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034631298 417 RvNPLhfPSALQYTLKDEV--MLRMLLNYGYDT 447
Cdd:PHA02875  199 K-NGC--VAALCYAIENNKidIVRLFIKRGADC 228
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 85-444 7.49e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.25  E-value: 7.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  85 PLHKAAVQLNRKILEITLS-ASDPSLweqTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEgnspLLAAVLRDCY 163
Cdd:PHA02876  181 PIHYAAERGNAKMVNLLLSyGADVNI---IALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLS----LLKAIRNEDL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 164 DMAALLINYGADVNLRCANERTALHEAAK---LGRedMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH-TEIMEMLLRKG 239
Cdd:PHA02876  254 ETSLLLYDAGFSVNSIDDCKNTPLHHASQapsLSR--LVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLG 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 240 ANAHGQASDSSSILLEAAS-GGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISP 317
Cdd:PHA02876  332 ADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYgADIEALSQKIGTA 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 318 VHCAAAGAHP-QCLELLIQAGFDVNfmldqRINKHYddhrKSALYFAVSNsdlssvklllsagalpnqdpvNClqialrm 396
Cdd:PHA02876  412 LHFALCGTNPyMSVKTLIDRGANVN-----SKNKDL----STPLHYACKK---------------------NC------- 454

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1034631298 397 gNYELISLLLRHGANVNYFCRVNPLHFPSALQYtlkdEVMLRMLLNYG 444
Cdd:PHA02876  455 -KLDVIEMLLDNGADVNAINIQNQYPLLIALEY----HGIVNILLHYG 497
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 55-341 4.86e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.37  E-value: 4.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  55 ETIEKgKEDALSHLTKYHSAfgeADEIGWIPLHKAAVQLNRKILEITLSASDPSlwEQTTHNGETPLFLAVSscllenat 134
Cdd:PHA02878   14 ETILK-YIEYIDHTENYSTS---ASLIPFIPLHQAVEARNLDVVKSLLTRGHNV--NQPDHRDLTPLHIICK-------- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 135 flllngcnpnAKNFEGNSPLLAAVLRDCYDMAALLIN---YGADVNL-------RCANERTA-LHEAAKLGRED-----M 198
Cdd:PHA02878   80 ----------EPNKLGMKEMIRSINKCSVFYTLVAIKdafNNRNVEIfkiiltnRYKNIQTIdLVYIDKKSKDDiieaeI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 199 VKLMLVSGAHPDPQSTY-GFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANI 277
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034631298 278 PKNSGHLPIHVAAdrGHLLA---LKILIPVTDLAAIKQS--GISPVHCAAAGahPQCLELLIQAGFDVN 341
Cdd:PHA02878  230 RDKCGNTPLHISV--GYCKDydiLKLLLEHGVDVNAKSYilGLTALHSSIKS--ERKLKLLLEYGADIN 294
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 133-412 5.80e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 5.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 133 ATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVN---------LRCA---------------------- 181
Cdd:PHA02876  161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiialddlsvLECAvdsknidtikaiidnrsninkn 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 182 ---------NE----------------------RTALHEAAK---LGRedMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 227
Cdd:PHA02876  241 dlsllkairNEdletslllydagfsvnsiddckNTPLHHASQapsLSR--LVPKLLERGADVNAKNIKGETPLYLMAKNG 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 228 H-TEIMEMLLRKGANAHGQASDSSSILLEAAS-GGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV- 304
Cdd:PHA02876  319 YdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYg 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 305 TDLAAIKQSGISPVHCAAAGAHP-QCLELLIQAGFDVNfmldqRINKHYddhrKSALYFAV-SNSDLSSVKLLLSAGA-- 380
Cdd:PHA02876  399 ADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVN-----SKNKDL----STPLHYACkKNCKLDVIEMLLDNGAdv 469

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1034631298 381 ----LPNQDPvncLQIALrmGNYELISLLLRHGANV 412
Cdd:PHA02876  470 nainIQNQYP---LLIAL--EYHGIVNILLHYGAEL 500
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 114-289 2.37e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.14  E-value: 2.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 114 THNGETPLFL--AVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAA 191
Cdd:PHA02874  119 IKDAELKTFLhyAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 192 KLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEImeMLLRKGANAHGQASDSSSILLEAAsggNP----DAVAL 267
Cdd:PHA02874  199 EYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPLHHAI---NPpcdiDIIDI 273

                         170       180
                  ....*....|....*....|..
gi 1034631298 268 LLEYGADANIPKNSGHLPIHVA 289
Cdd:PHA02874  274 LLYHKADISIKDNKGENPIDTA 295
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 530-571 3.42e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 57.95  E-value: 3.42e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVL 571
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGK---RRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 111-321 2.77e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 2.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 111 EQTThngeTPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVN---LRCANertal 187
Cdd:PHA02874   33 DETT----TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSilpIPCIE----- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 188 heaaklgrEDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVAL 267
Cdd:PHA02874  104 --------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034631298 268 LLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIK-QSGISPVHCA 321
Cdd:PHA02874  176 LLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNA 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 62-289 6.65e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 6.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  62 EDALSHLTKYHSAFG--EADEIGWIPLHKA--AVQLNR---KILEITLSASDPSLweqtthNGETPLFL-AVSSCLLENA 133
Cdd:PHA02876  251 EDLETSLLLYDAGFSvnSIDDCKNTPLHHAsqAPSLSRlvpKLLERGADVNAKNI------KGETPLYLmAKNGYDTENI 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 134 TFLLLNGCNPNAKNFEGNSPLLAAVLRDCY-DMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQ 212
Cdd:PHA02876  325 RTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAL 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 213 STYGFTPL--ALAAQSGHTEImEMLLRKGANAHGQASDSSSILLEAASGG-NPDAVALLLEYGADANIPKNSGHLPIHVA 289
Cdd:PHA02876  405 SQKIGTALhfALCGTNPYMSV-KTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIA 483
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 165-446 8.11e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.62  E-value: 8.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 165 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHg 244
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN- 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 245 qASDSSsiLLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL--LALKILIPVTDLAAIKQSGISPVHCAA 322
Cdd:PHA02876  239 -KNDLS--LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsrLVPKLLERGADVNAKNIKGETPLYLMA 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 323 A-GAHPQCLELLIQAGFDVN--------------------------FMLDQRINKHyDDHRKSALYFAVSNSDLSSVKLL 375
Cdd:PHA02876  316 KnGYDTENIRTLIMLGADVNaadrlyitplhqastldrnkdivitlLELGANVNAR-DYCDKTPIHYAAVRNNVVIINTL 394

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631298 376 LSAGA---LPNQDPVNCLQIALRMGN-YELISLLLRHGANVNYFCR--VNPLHFpsALQYTLKDEVmLRMLLNYGYD 446
Cdd:PHA02876  395 LDYGAdieALSQKIGTALHFALCGTNpYMSVKTLIDRGANVNSKNKdlSTPLHY--ACKKNCKLDV-IEMLLDNGAD 468
Ank_2 pfam12796
Ankyrin repeats (3 copies);
319-413 1.76e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 319 HCAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP-VNCLQIALRMG 397
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNgRTALHYAARSG 72

                          90
                  ....*....|....*.
gi 1034631298 398 NYELISLLLRHGANVN 413
Cdd:pfam12796  73 HLEIVKLLLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
286-384 2.92e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 2.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 286 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQagfdvnfmldqRINKHYDDHRKSALYFAV 364
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1034631298 365 SNSDLSSVKLLLSAGALPNQ 384
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 112-247 6.60e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.49  E-value: 6.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 112 QTTHNGETPLFLAVSSCLLENATFLLL-NGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGAD-VNLRCANE----RT 185
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgET 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034631298 186 ALHEAAKLGREDMVKLMLVSGA--------------HPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQAS 247
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGAdvvspratgtffrpGPKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 265-446 1.13e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.58  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 265 VALLLEYGADANI-PKNSGHLPIHVAADRghllalkiliPVTDLAaikqsgispvhcaaagahpqclELLIQAGFDVNFM 343
Cdd:PHA02878  150 TKLLLSYGADINMkDRHKGNTALHYATEN----------KDQRLT----------------------ELLLSYGANVNIP 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 344 ldqrinkhyDDHRKSALYFAVSNSDLSSVKLLLSAGAlpNQDPVNC-----LQIAL-RMGNYELISLLLRHGANVNYFCR 417
Cdd:PHA02878  198 ---------DKTNNSPLHHAVKHYNKPIVHILLENGA--STDARDKcgntpLHISVgYCKDYDILKLLLEHGVDVNAKSY 266

                         170       180
                  ....*....|....*....|....*....
gi 1034631298 418 VNPLhfpSALQYTLKDEVMLRMLLNYGYD 446
Cdd:PHA02878  267 ILGL---TALHSSIKSERKLKLLLEYGAD 292
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 532-573 1.60e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.48  E-value: 1.60e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034631298  532 RSLKHLCRLKIRKCMGrlhlrcpvFMSFLPLPNRLKAYVLYK 573
Cdd:smart00969   1 RSLQHLCRLAIRRSLG--------GIDKLPLPPRLKDYLLYY 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
183-236 3.21e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 3.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034631298 183 ERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLL 236
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-147 3.96e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  57 IEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITLSASDPSLWEqtthNGETPLFLAVSSCLLENATFL 136
Cdd:pfam12796   5 AKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 1034631298 137 LLNGCNPNAKN 147
Cdd:pfam12796  81 LEKGADINVKD 91
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 529-573 4.43e-08

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 49.22  E-value: 4.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034631298  529 TNPRSLKHLCRLKIRKCMGRLHLRCpvfmsfLPLPNRLKAYVLYK 573
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIKT------LPLPPKLKDYLSYY 43
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 130-289 4.69e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 4.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 130 LENATF--LLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGA 207
Cdd:PHA02874  102 IEKDMIktILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 208 HPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSIlLEAASGGNPDAVALLLEyGADANIPKNSGHLPIH 287
Cdd:PHA02874  182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP-LHNAIIHNRSAIELLIN-NASINDQDIDGSTPLH 259


                  ..
gi 1034631298 288 VA 289
Cdd:PHA02874  260 HA 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 166-267 5.19e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 5.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 166 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRK------- 238
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqchfel 177

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1034631298 239 GANAHGQASDS--SSILLEAASGGNPDAVAL 267
Cdd:PTZ00322  178 GANAKPDSFTGkpPSLEDSPISSHHPDFSAV 208
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 225-427 6.18e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 6.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 225 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIpv 304
Cdd:PHA02876  154 QQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAII-- 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 305 TDLAAIKQSGISPVHcAAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSALYFAVSNSDLSS-VKLLLSAGALPN 383
Cdd:PHA02876  232 DNRSNINKNDLSLLK-AIRNEDLETSLLLYDAGFSVNSI---------DDCKNTPLHHASQAPSLSRlVPKLLERGADVN 301

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034631298 384 QDPVNC---LQIALRMG-NYELISLLLRHGANVNYFCR--VNPLHFPSAL 427
Cdd:PHA02876  302 AKNIKGetpLYLMAKNGyDTENIRTLIMLGADVNAADRlyITPLHQASTL 351
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 529-573 1.07e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 48.36  E-value: 1.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034631298 529 TNPRSLKHLCRLKIRKCMGRLHLRCpvfmsfLPLPNRLKAYVLYK 573
Cdd:cd03717     1 TSVRSLQHLCRFVIRQCTRRDLIDQ------LPLPRRLKDYLKEY 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 190-340 1.64e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.49  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 190 AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLL 269
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034631298 270 EYGADANiPKNSGHLpIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDV 340
Cdd:PLN03192  612 HFASISD-PHAAGDL-LCTAAKRNDLTAMKELLKQgLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
Ank_4 pfam13637
Ankyrin repeats (many copies);
150-203 2.03e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 2.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034631298 150 GNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLML 203
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
360-446 3.56e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 3.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 360 LYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFpsALQYTLKDevM 436
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAdanLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRTALHY--AARSGHLE--I 76

                          90
                  ....*....|
gi 1034631298 437 LRMLLNYGYD 446
Cdd:pfam12796  77 VKLLLEKGAD 86
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 533-574 3.57e-07

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 47.09  E-value: 3.57e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034631298 533 SLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 574
Cdd:cd03722     5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 94-241 3.97e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.33  E-value: 3.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  94 NRKILEITLSAS-DPSLWEQTthnGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINY 172
Cdd:PLN03192  537 NAALLEELLKAKlDPDIGDSK---GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHF 613

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034631298 173 GADVNLRCANErtALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGAN 241
Cdd:PLN03192  614 ASISDPHAAGD--LLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 530-571 4.04e-07

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 46.66  E-value: 4.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVL 571
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGS---RCHKLVPQLSLPTSLKNYLL 40
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 150-302 4.15e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.95  E-value: 4.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 150 GNSPLLAAVLRDcydmaallinyGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT 229
Cdd:PLN03192  536 GNAALLEELLKA-----------KLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHH 604

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034631298 230 EIMEMLLRKGANAHGQAsdSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI 302
Cdd:PLN03192  605 KIFRILYHFASISDPHA--AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA03095 PHA03095
ankyrin-like protein; Provisional
 246-446 6.99e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 6.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 246 ASDSSSILLEAASGGNPDA--VALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV----TDLAAIKQSGISPVH 319
Cdd:PHA03095    9 IIMEAALYDYLLNASNVTVeeVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLleagADVNAPERCGFTPLH 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 320 C-AAAGAHPQCLELLIQAGFDVNFMldqrinkhyDDHRKSAL--YFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIA 393
Cdd:PHA03095   89 LyLYNATTLDVIKLLIKAGADVNAK---------DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNaldLYGMTPLAVL 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631298 394 LRMGN--YELISLLLRHGANVNY--FCRVNPLHfpSALQYTLKDEVMLRMLLNYGYD 446
Cdd:PHA03095  160 LKSRNanVELLRLLIDAGADVYAvdDRFRSLLH--HHLQSFKPRARIVRELIRAGCD 214
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 531-574 1.84e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 44.86  E-value: 1.84e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 531 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYKE 574
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 340-446 3.13e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.66  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 340 VNFMLDQRINKH-YDDHRKSALYF-----AVSNSDLSSVKLLLSAGALPN-QDPVNC--LQIAL--RMGNYELISLLLRH 408
Cdd:PHA03100   51 VKILLDNGADINsSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNaPDNNGItpLLYAIskKSNSYSIVEYLLDN 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034631298 409 GANVN--YFCRVNPLHFpsALQYTLKDEVMLRMLLNYGYD 446
Cdd:PHA03100  131 GANVNikNSDGENLLHL--YLESNKIDLKILKLLIDKGVD 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 79-220 4.03e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  79 DEIGWIPLHKAAvqlnrkiLEITLSASDPSLWEQTTHNGETPL---FLAVSSCLLE------NATFLLLNGCNPNAKNFE 149
Cdd:PTZ00322   42 EEIARIDTHLEA-------LEATENKDATPDHNLTTEEVIDPVvahMLTVELCQLAasgdavGARILLTGGADPNCRDYD 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034631298 150 GNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLV-------SGAHPDPQSTYGFTPL 220
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhsqchfeLGANAKPDSFTGKPPS 192
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 253-446 5.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.11  E-value: 5.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 253 LLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIpvtdlAAIKQSGISPVHCAAAGA----HPQ 328
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI-----RSINKCSVFYTLVAIKDAfnnrNVE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 329 CLELLIQAGFDVNFMLDQR-------------------------INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPN 383
Cdd:PHA02878  116 IFKIILTNRYKNIQTIDLVyidkkskddiieaeitklllsygadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVN 195

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034631298 384 QdPVNC----LQIALRMGNYELISLLLRHGANVNY--FCRVNPLHFPSAlqyTLKDEVMLRMLLNYGYD 446
Cdd:PHA02878  196 I-PDKTnnspLHHAVKHYNKPIVHILLENGASTDArdKCGNTPLHISVG---YCKDYDILKLLLEHGVD 260
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 531-573 1.14e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 42.67  E-value: 1.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034631298 531 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYK 573
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRLE---EIEQLPLPPSLKNYLLYQ 42
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 84-238 1.16e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.09  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  84 IPLHKAAVQLNRKILEITLSASDPSLWEQTTHnGETPLFLAVSSCLLENATFLLlnGCNPNAKN-------FEGNSPLLA 156
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGAL-GETALHVAALYDNLEAAVVLM--EAAPELVNepmtsdlYQGETALHI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 157 AVLRDCYDMAALLINYGADVnlrcANERTA------------------LHEAAKLGREDMVKLMLVSGAHPDPQSTYG-- 216
Cdd:cd22192    96 AVVNQNLNLVRELIARGADV----VSPRATgtffrpgpknliyygehpLSFAACVGNEEIVRLLIEHGADIRAQDSLGnt 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034631298 217 -----------------------------------------FTPLALAAQSGHTEIMEMLLRK 238
Cdd:cd22192   172 vlhilvlqpnktfacqmydlilsydkeddlqpldlvpnnqgLTPFKLAAKEGNIVMFQHLVQK 234
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 531-576 1.26e-05

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 42.53  E-value: 1.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034631298 531 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYKEYD 576
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNLK---LLDELPIAKVMKDYLKHKFDD 45
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 142-274 2.14e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.38  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 142 NPNAKNFEGNSPLLAAVLR-DCYDMAALLINYGADVnlrcANERTALHEAAKL---GREDMVKLMLVSGAHPDPQS---- 213
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIEnENLELTELLLNLSCRG----AVGDTLLHAISLEyvdAVEAILLHLLAAFRKSGPLEland 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 214 ------TYGFTPLALAAQSGHTEIMEMLLRKGANAH----------GQASD----SSSILLEAASGGNPDAVALLLEYGA 273
Cdd:TIGR00870 120 qytsefTPGITALHLAAHRQNYEIVKLLLERGASVParacgdffvkSQGVDsfyhGESPLNAAACLGSPSIVALLSEDPA 199


                  .
gi 1034631298 274 D 274
Cdd:TIGR00870 200 D 200
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 531-573 3.31e-05

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 41.40  E-value: 3.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034631298 531 PRSLKHLCRLKIRKCMG--RLHLrcpvfMSFLPLPNRLKAYVLYK 573
Cdd:cd03724     3 PSSLCQLCRLCIRNYIGrsRLHL-----IPQLQLPTLLKNFLQYR 42
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 145-299 3.42e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 46.68  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 145 AKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRcanertalheaaklgredmVKLMLVSGAHPDPQSTYGFTPLALAA 224
Cdd:cd22194   136 EEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAH-------------------AKGVFFNPKYKHEGFYFGETPLALAA 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 225 QSGHTEIMEMLLRKGA-NAHGQASDSSSIL---LEAA--SGGNPDAVA----LLLEYGADAN---IPKNSGHLPIHVAAD 291
Cdd:cd22194   197 CTNQPEIVQLLMEKEStDITSQDSRGNTVLhalVTVAedSKTQNDFVKrmydMILLKSENKNletIRNNEGLTPLQLAAK 276


                  ....*...
gi 1034631298 292 RGHLLALK 299
Cdd:cd22194   277 MGKAEILK 284
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 529-575 4.80e-05

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 40.60  E-value: 4.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034631298 529 TNPRSLKHLCRLKIRKCMGRLHLrcpvfmsfLPLPNRLKAYVlyKEY 575
Cdd:cd03736     1 TSTPSLQHLCRITINKCTRQIQE--------LPLPTRLKDYL--TEY 37
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 530-572 6.89e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 40.48  E-value: 6.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLY 572
Cdd:cd03720     2 NPRSLLSLCRIAVRRALGKQRLS---LICSLPLPDPIKKFLLH 41
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 530-575 7.21e-05

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 40.47  E-value: 7.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRLHLRCpvfmsfLPLPNRLKAYVLYKEY 575
Cdd:cd03741     2 NVQSLQHLCRFVIRKLVRRDHIPA------LPLPRRLIDYLREKHY 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
250-302 8.49e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 8.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034631298 250 SSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI 302
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 85-217 1.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  85 PLHKAAVQLNRKILEITLSasDPSLWEQTTHNGETPLFLAVSSCL-LENATFLLLNGCNPNAKNFEGNSPLLAAVLRDcY 163
Cdd:PHA02878  204 PLHHAVKHYNKPIVHILLE--NGASTDARDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSYILGLTALHSSIKS-E 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 164 DMAALLINYGADVNLRCANERTALHEAAK------LGREDMVKLMLVSGAHPDPQSTYGF 217
Cdd:PHA02878  281 RKLKLLLEYGADINSLNSYKLTPLSSAVKqylcinIGRILISNICLLKRIKPDIKNSEGF 340
Ank_5 pfam13857
Ankyrin repeats (many copies);
136-190 1.61e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034631298 136 LLLNG-CNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEA 190
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 116-177 1.73e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 1.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034631298 116 NGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVN 177
Cdd:PHA03100  191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 532-575 3.04e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 38.55  E-value: 3.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 532 RSLKHLCRLKIRKCMGRLHLRcpvfmsFLPLPNRLKAYVLYKEY 575
Cdd:cd03740     4 RSLQYLCRFVIRQYTRIDLIQ------KLPLPNKMKGYLLEKHY 41
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 215-241 3.92e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.92e-04
                           10        20
                   ....*....|....*....|....*..
gi 1034631298  215 YGFTPLALAAQSGHTEIMEMLLRKGAN 241
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
PHA02798 PHA02798
ankyrin-like protein; Provisional
 139-241 4.14e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.28  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 139 NGCNPNAKNFEGNSPLLAAV-----LRDCYDMAALLINYGADVNLRCANERTALH---EAAKLGREDMVKLMLVSGAHPD 210
Cdd:PHA02798   60 LGANVNGLDNEYSTPLCTILsnikdYKHMLDIVKILIENGADINKKNSDGETPLYcllSNGYINNLEILLFMIENGADTT 139

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1034631298 211 PQSTYGFTPLALAAQSGHT---EIMEMLLRKGAN 241
Cdd:PHA02798  140 LLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVD 173
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 530-573 4.55e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 38.23  E-value: 4.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 530 NPRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 573
Cdd:cd03729     2 TPLSLQQLCRINLRKALGT---RALEKIAKLNIPNRIIDYLSYN 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 531-573 4.66e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 38.08  E-value: 4.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034631298 531 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYK 573
Cdd:cd03719     3 PHSLLHLSRLCVRHALGDTRLG---QVSALPLPPAMKRYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
218-269 4.89e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 4.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034631298 218 TPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLL 269
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 531-571 5.38e-04

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 37.81  E-value: 5.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034631298 531 PRSLKHLCRLKIRKCMGRLHLRCPVfmSFLPLPNRLKAYVL 571
Cdd:cd03725     3 PPPLKHLCRVFIRLCLRPWPVDVKV--KALPLPDRLKWYLL 41
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 199-281 6.45e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 6.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 199 VKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG-----A 273
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSqchfeL 177


                  ....*...
gi 1034631298 274 DANIPKNS 281
Cdd:PTZ00322  178 GANAKPDS 185
Ank_4 pfam13637
Ankyrin repeats (many copies);
119-170 7.54e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 7.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034631298 119 TPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLI 170
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 80-238 9.39e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 42.17  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  80 EIGWIPLHKAAVQLNRKILE-ITL--------SASDPSLWEQTT---HNGETPLFLAVSSCLLENATFLLLNGCNPNAKN 147
Cdd:cd21882    24 ATGKTCLHKAALNLNDGVNEaIMLlleaapdsGNPKELVNAPCTdefYQGQTALHIAIENRNLNLVRLLVENGADVSARA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 148 -------------FEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANE---RTALH----------EAAKLGREdMVKL 201
Cdd:cd21882   104 tgrffrkspgnlfYFGELPLSLAACTNQEEIVRLLLENGAQPAALEAQDslgNTVLHalvlqadntpENSAFVCQ-MYNL 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 202 MLVSGAHPDP-------QSTYGFTPLALAAQSGHTEIMEMLLRK 238
Cdd:cd21882   183 LLSYGAHLDPtqqleeiPNHQGLTPLKLAAVEGKIVMFQHILQR 226
PHA02946 PHA02946
ankyin-like protein; Provisional
 136-318 1.21e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 136 LLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGRE--DMVKLMLVSGAHPDPQ- 212
Cdd:PHA02946   58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKINNSv 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 213 STYGFTPLaLAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDA--VALLLEYGADANIPKNSGHLPIHVAA 290
Cdd:PHA02946  138 DEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKAstISWMMKLGISPSKPDHDGNTPLHIVC 216

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034631298 291 DR--GHLLALKILIPVTDLAAIKQSGISPV 318
Cdd:PHA02946  217 SKtvKNVDIINLLLPSTDVNKQNKFGDSPL 246
Ank_4 pfam13637
Ankyrin repeats (many copies);
285-334 1.45e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034631298 285 PIHVAADRGHLLALKILIPVT-DLAAIKQSGISPVHCAAAGAHPQCLELLI 334
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGaDINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 248-447 1.45e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 248 DSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLalkilipvTDLAAIkqsgispvhcaaagahp 327
Cdd:PHA03100   34 KPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNL--------TDVKEI----------------- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 328 qcLELLIQAGFDVNfmldqrinkHYDDHRKSALYFAVSNS--DLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL- 401
Cdd:PHA03100   89 --VKLLLEYGANVN---------APDNNGITPLLYAISKKsnSYSIVEYLLDNGAnvnIKNSDGENLLHLYLESNKIDLk 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1034631298 402 -ISLLLRHGANVNYFCRVNplhfpsalqytlkdevmlrMLLNYGYDT 447
Cdd:PHA03100  158 iLKLLIDKGVDINAKNRVN-------------------YLLSYGVPI 185
Ank_4 pfam13637
Ankyrin repeats (many copies);
316-376 1.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034631298 316 SPVHCAAAGAHPQCLELLIQAGFDVNfmlDQRINKhyddhrKSALYFAVSNSDLSSVKLLL 376
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN---AVDGNG------ETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
168-223 1.94e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 1.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034631298 168 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALA 223
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 531-573 2.47e-03

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 35.92  E-value: 2.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034631298 531 PRSLKHLCRLKIRKCMGRlhlRCPVFMSFLPLPNRLKAYVLYK 573
Cdd:cd03728     3 PPSLMQLCRLCIRKCFGR---KQHHKIHKLHLPEPLKHFLLYR 42
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 531-573 2.76e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 35.73  E-value: 2.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034631298 531 PRSLKHLCRLKIRKCMGRLHLRcpvFMSFLPLPNRLKAYVLYK 573
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLS---EIHTLPLPASLKNYLLYQ 42
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 342-461 2.82e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.36  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 342 FMLDQRINKHYDDHRK-SALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVN---Y 414
Cdd:PHA02875   20 RLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDvkyPDIESELHDAVEEGDVKAVEELLDLGKFADdvfY 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034631298 415 FCRVNPLHFPSALQytlKDEVMlRMLLNYGYDTercfDCPHGDKVHP 461
Cdd:PHA02875  100 KDGMTPLHLATILK---KLDIM-KLLIARGADP----DIPNTDKFSP 138
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 532-575 4.44e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 35.32  E-value: 4.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034631298 532 RSLKHLCRLKIRKCMGRLHLrcpvfmsfLPLPNRLKAYVlyKEY 575
Cdd:cd03734     4 RSLQHLCRLVINRLVTDVDC--------LPLPRRMADYL--RQY 37
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 215-241 4.78e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034631298 215 YGFTPLALAA-QSGHTEIMEMLLRKGAN 241
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGAD 28
Ank_4 pfam13637
Ankyrin repeats (many copies);
358-406 5.31e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 5.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034631298 358 SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELISLLL 406
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNgetALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 55-170 5.54e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298  55 ETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQ-LNRKILEITLSASdPSLWEQTTHNGETPLFLAVSScllENA 133
Cdd:PHA02878  207 HAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHG-VDVNAKSYILGLTALHSSIKS---ERK 282

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034631298 134 TFLLLN-GCNPNAKNFEGNSPLLAAVL-RDCYDMAALLI 170
Cdd:PHA02878  283 LKLLLEyGADINSLNSYKLTPLSSAVKqYLCINIGRILI 321
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 149-179 7.82e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.19  E-value: 7.82e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034631298 149 EGNSPL-LAAVLRDCYDMAALLINYGADVNLR 179
Cdd:pfam00023   1 DGNTPLhLAAGRRGNLEIVKLLLSKGADVNAR 32
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 150-308 8.07e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 39.09  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 150 GNSPLLAAVLRD---CYDMAALLINYGAD-------VNLRCANE----RTALHEAAKLGREDMVKLMLVSGA-------- 207
Cdd:cd21882    26 GKTCLHKAALNLndgVNEAIMLLLEAAPDsgnpkelVNAPCTDEfyqgQTALHIAIENRNLNLVRLLVENGAdvsaratg 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631298 208 -----HPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGAN-AHGQASDSSS-----ILLEAASgGNPDAVA-------LLL 269
Cdd:cd21882   106 rffrkSPGNLFYFGELPLSLAACTNQEEIVRLLLENGAQpAALEAQDSLGntvlhALVLQAD-NTPENSAfvcqmynLLL 184

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034631298 270 EYGADAN-------IPKNSGHLPIHVAADRG------HLLALKILIPVTDLA 308
Cdd:cd21882   185 SYGAHLDptqqleeIPNHQGLTPLKLAAVEGkivmfqHILQREFSGPYQPLS 236
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 215-243 8.43e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 8.43e-03
                          10        20
                  ....*....|....*....|....*....
gi 1034631298 215 YGFTPLALAAQSGHTEIMEMLLRKGANAH 243
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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