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Conserved domains on  [gi|1034616569|ref|XP_016860401|]
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FAST kinase domain-containing protein 1, mitochondrial isoform X6 [Homo sapiens]

Protein Classification

RAP domain-containing protein; endonuclease( domain architecture ID 10535838)

RAP domain-containing protein binds RNA, similar to Arabidopsis thaliana RAP domain-containing protein (AtRAP) that binds to the 16S rRNA precursor, is involved in its 5'-end processing, and is required for chloroplast 16S rRNA maturation, an important process which supports chloroplast gene expression and biogenesis; uncharacterized endonuclease similar to NucS, which cleaves both 3' and 5' ssDNA extremities of branched DNA structures

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 255-324 3.56e-22

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 89.85  E-value: 3.56e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 255 AIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLD 324
Cdd:pfam06743   3 SLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 416-475 8.59e-17

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


:

Pssm-ID: 214932  Cd Length: 58  Bit Score: 74.19  E-value: 8.59e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  416 LEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMalSTKDARMDYLREC 475
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKL--KSEDEKVEYLKEK 58
FAST_2 super family cl07113
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 337-380 1.83e-13

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


The actual alignment was detected with superfamily member pfam08368:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 65.67  E-value: 1.83e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034616569 337 QQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLP 380
Cdd:pfam08368  46 QKEVLEALKELLGGENYFRSNVLTPYGYTIDFECKLDKDGKPLP 89
RESC8-like super family cl46255
RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, ...
 14-330 1.33e-03

RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, MRB10130) is a component of the RNA-editing substrate-binding complex (RESC) that is composed of about 20-components and is involved in kinetoplast RNA processing. RESC8 with RESC10, and RESC14 are RESC organizers which are important for modulating proper protein-protein-RNA rearrangements during editing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC8 is predicted (by AlphaFold) to adopt an all-helical structure, with a lower confidence in prediction of the N-terminal 100 residues. The helical structure that is predicted with high confidence, representing the middle and most of the C-terminal region, resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions.


The actual alignment was detected with superfamily member cd23736:

Pssm-ID: 467929 [Multi-domain]  Cd Length: 514  Bit Score: 41.22  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  14 EDLTGEQALAVLGAMGDMESRNSCLIKRVTSVLHKHLDGYKPLELLKITQELTFLHFQRKEFFAKLRELLLSYlKNSFIP 93
Cdd:cd23736    90 EAISPESLLNVLRSMNVHGTRDERKIQEVLKALPPLLDEFSPTQLSLLVRELAKLNYTNADFTNKIAKRGCEV-ASDLST 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  94 TEVSVLVRAISLLPS-PHLDEVGI-SRIEAVLPQCD----------LNNLSS-----FATSVLRWIQH----DHMYLDN- 151
Cdd:cd23736   169 MDLSLTFFNLAKLRGvSHDSLRRAvNLIEARMEEFQpedyvnvlmaLERQGPafartFRKLVEAALSHvenmDAVTLTRf 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 152 ---MTAKQLKLLQKLDHYGRQRLQHSNSL---DLLRKELKSLKGNTFPESLLEEMIATLQHFMDDINYINVGEIASFISS 225
Cdd:cd23736   249 lvtFAAMDYSQREHVEIYADALVDVASDLsekDLVQALVALQRLDLLSEEGFSELASCLMRYAANLDPRHIDPVMDICSV 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 226 ----TDYLSTLLLDRiasvAVQQIEKIHPFTIPAIIrpfSVLNYDPPQRDEflgTCVQHLNSY----LGILDPFILVFLG 297
Cdd:cd23736   329 vphdSDGLMKVLLDR----AVECTRMLSPNQLAFIL---DLLSLYPPAKGH---ALVEAFGKQarlrAELMDPEALARAT 398

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1034616569 298 FSLATLEYFPEDL--LKAIFNIKFLARLDSQLESI 330
Cdd:cd23736   399 RGLAQLGYRDDDFytQAAVLQFRYGFKSWSLLEPI 433
 
Name Accession Description Interval E-value
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 255-324 3.56e-22

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 89.85  E-value: 3.56e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 255 AIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLD 324
Cdd:pfam06743   3 SLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 416-475 8.59e-17

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 74.19  E-value: 8.59e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  416 LEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMalSTKDARMDYLREC 475
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKL--KSEDEKVEYLKEK 58
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 337-380 1.83e-13

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 65.67  E-value: 1.83e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034616569 337 QQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLP 380
Cdd:pfam08368  46 QKEVLEALKELLGGENYFRSNVLTPYGYTIDFECKLDKDGKPLP 89
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 416-474 6.68e-13

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 63.37  E-value: 6.68e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034616569 416 LEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSmaLSTKDARMDYLRE 474
Cdd:pfam08373   1 IEVDGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQ--LKTKEEKVEYLKK 57
RESC8-like cd23736
RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, ...
 14-330 1.33e-03

RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, MRB10130) is a component of the RNA-editing substrate-binding complex (RESC) that is composed of about 20-components and is involved in kinetoplast RNA processing. RESC8 with RESC10, and RESC14 are RESC organizers which are important for modulating proper protein-protein-RNA rearrangements during editing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC8 is predicted (by AlphaFold) to adopt an all-helical structure, with a lower confidence in prediction of the N-terminal 100 residues. The helical structure that is predicted with high confidence, representing the middle and most of the C-terminal region, resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions.


Pssm-ID: 467929 [Multi-domain]  Cd Length: 514  Bit Score: 41.22  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  14 EDLTGEQALAVLGAMGDMESRNSCLIKRVTSVLHKHLDGYKPLELLKITQELTFLHFQRKEFFAKLRELLLSYlKNSFIP 93
Cdd:cd23736    90 EAISPESLLNVLRSMNVHGTRDERKIQEVLKALPPLLDEFSPTQLSLLVRELAKLNYTNADFTNKIAKRGCEV-ASDLST 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  94 TEVSVLVRAISLLPS-PHLDEVGI-SRIEAVLPQCD----------LNNLSS-----FATSVLRWIQH----DHMYLDN- 151
Cdd:cd23736   169 MDLSLTFFNLAKLRGvSHDSLRRAvNLIEARMEEFQpedyvnvlmaLERQGPafartFRKLVEAALSHvenmDAVTLTRf 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 152 ---MTAKQLKLLQKLDHYGRQRLQHSNSL---DLLRKELKSLKGNTFPESLLEEMIATLQHFMDDINYINVGEIASFISS 225
Cdd:cd23736   249 lvtFAAMDYSQREHVEIYADALVDVASDLsekDLVQALVALQRLDLLSEEGFSELASCLMRYAANLDPRHIDPVMDICSV 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 226 ----TDYLSTLLLDRiasvAVQQIEKIHPFTIPAIIrpfSVLNYDPPQRDEflgTCVQHLNSY----LGILDPFILVFLG 297
Cdd:cd23736   329 vphdSDGLMKVLLDR----AVECTRMLSPNQLAFIL---DLLSLYPPAKGH---ALVEAFGKQarlrAELMDPEALARAT 398

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1034616569 298 FSLATLEYFPEDL--LKAIFNIKFLARLDSQLESI 330
Cdd:cd23736   399 RGLAQLGYRDDDFytQAAVLQFRYGFKSWSLLEPI 433
 
Name Accession Description Interval E-value
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 255-324 3.56e-22

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 89.85  E-value: 3.56e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 255 AIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLD 324
Cdd:pfam06743   3 SLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 416-475 8.59e-17

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 74.19  E-value: 8.59e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  416 LEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMalSTKDARMDYLREC 475
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKL--KSEDEKVEYLKEK 58
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 337-380 1.83e-13

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 65.67  E-value: 1.83e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034616569 337 QQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLP 380
Cdd:pfam08368  46 QKEVLEALKELLGGENYFRSNVLTPYGYTIDFECKLDKDGKPLP 89
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 416-474 6.68e-13

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 63.37  E-value: 6.68e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034616569 416 LEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNSmaLSTKDARMDYLRE 474
Cdd:pfam08373   1 IEVDGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQ--LKTKEEKVEYLKK 57
RESC8-like cd23736
RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, ...
 14-330 1.33e-03

RNA-editing substrate-binding complex subunit 8 (RESC8) and related proteins; RESC8 (REMC1, MRB10130) is a component of the RNA-editing substrate-binding complex (RESC) that is composed of about 20-components and is involved in kinetoplast RNA processing. RESC8 with RESC10, and RESC14 are RESC organizers which are important for modulating proper protein-protein-RNA rearrangements during editing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC8 is predicted (by AlphaFold) to adopt an all-helical structure, with a lower confidence in prediction of the N-terminal 100 residues. The helical structure that is predicted with high confidence, representing the middle and most of the C-terminal region, resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions.


Pssm-ID: 467929 [Multi-domain]  Cd Length: 514  Bit Score: 41.22  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  14 EDLTGEQALAVLGAMGDMESRNSCLIKRVTSVLHKHLDGYKPLELLKITQELTFLHFQRKEFFAKLRELLLSYlKNSFIP 93
Cdd:cd23736    90 EAISPESLLNVLRSMNVHGTRDERKIQEVLKALPPLLDEFSPTQLSLLVRELAKLNYTNADFTNKIAKRGCEV-ASDLST 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569  94 TEVSVLVRAISLLPS-PHLDEVGI-SRIEAVLPQCD----------LNNLSS-----FATSVLRWIQH----DHMYLDN- 151
Cdd:cd23736   169 MDLSLTFFNLAKLRGvSHDSLRRAvNLIEARMEEFQpedyvnvlmaLERQGPafartFRKLVEAALSHvenmDAVTLTRf 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 152 ---MTAKQLKLLQKLDHYGRQRLQHSNSL---DLLRKELKSLKGNTFPESLLEEMIATLQHFMDDINYINVGEIASFISS 225
Cdd:cd23736   249 lvtFAAMDYSQREHVEIYADALVDVASDLsekDLVQALVALQRLDLLSEEGFSELASCLMRYAANLDPRHIDPVMDICSV 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034616569 226 ----TDYLSTLLLDRiasvAVQQIEKIHPFTIPAIIrpfSVLNYDPPQRDEflgTCVQHLNSY----LGILDPFILVFLG 297
Cdd:cd23736   329 vphdSDGLMKVLLDR----AVECTRMLSPNQLAFIL---DLLSLYPPAKGH---ALVEAFGKQarlrAELMDPEALARAT 398

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1034616569 298 FSLATLEYFPEDL--LKAIFNIKFLARLDSQLESI 330
Cdd:cd23736   399 RGLAQLGYRDDDFytQAAVLQFRYGFKSWSLLEPI 433
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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