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Conserved domains on  [gi|1034561470|ref|XP_016857697|]
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toll-like receptor 5 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 693-837 4.58e-37

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 136.73  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 693 YDAYLCFS-SKDFTWVQNALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:pfam01582   1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 772 FSYAQGRCLsDLNSALIMVVVGSLSQYQL-------MKHQSIRGFVQKQQYLRWPEDL------------QDVGWFLHKL 832
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154


                  ....*
gi 1034561470 833 SQQIL 837
Cdd:pfam01582 155 AYDIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-577 4.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 288 SSVRHLDLShgfvfslNSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886    96 TNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRV 447
Cdd:COG4886   167 SNNQLTDL-PEELGNLTNLKELDLSNNQIT------DLPEPLGNLTNLEEL----------DLSGNQLTDLPE--PLANL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 448 PHLQILILNQNRFSSCsgdqtpsenPSLEQLflgenmlqlawetelcwdvfeglSHLQVLYLNHNYLNSLPPgvFSHLTA 527
Cdd:COG4886   228 TNLETLDLSNNQLTDL---------PELGNL-----------------------TNLEELDLSNNQLTDLPP--LANLTN 273

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561470 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDIT 577
Cdd:COG4886   274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR_8 pfam13855
Leucine rich repeat;
95-182 5.58e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  95 PNLRILDLGSSKIYFLHPDAFQGlfhlfelrlyfcglsdavlkdgyfrnLKALTRLDLSKNQIRSLYLHpSFGKLNSLKS 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------LSNLKVLDLSNNLLTTLSPG-AFSGLPSLRY 53


                  ....*...
gi 1034561470 175 IDFSSNQI 182
Cdd:pfam13855  54 LDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 554-634 2.43e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  554 DISRNQLLAPNPDVF---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIyCVYPDSFSGVSLF--SLSTEG 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAL-CAGPGALAGQPLLgiPLLDSG 79


                   ....*.
gi 1034561470  629 CDEEEV 634
Cdd:TIGR00864   80 CDEEYV 85
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 693-837 4.58e-37

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 136.73  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 693 YDAYLCFS-SKDFTWVQNALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:pfam01582   1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 772 FSYAQGRCLsDLNSALIMVVVGSLSQYQL-------MKHQSIRGFVQKQQYLRWPEDL------------QDVGWFLHKL 832
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154


                  ....*
gi 1034561470 833 SQQIL 837
Cdd:pfam01582 155 AYDIS 159
TIR smart00255
Toll - interleukin 1 - resistance;
692-827 4.81e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.02  E-value: 4.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  692 KYDAYLCFSSKDftWVQNALLKHLDTQYSdqnRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034561470  772 FSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKqQYLRWPEDLQDVGW 827
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-577 4.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 288 SSVRHLDLShgfvfslNSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886    96 TNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRV 447
Cdd:COG4886   167 SNNQLTDL-PEELGNLTNLKELDLSNNQIT------DLPEPLGNLTNLEEL----------DLSGNQLTDLPE--PLANL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 448 PHLQILILNQNRFSSCsgdqtpsenPSLEQLflgenmlqlawetelcwdvfeglSHLQVLYLNHNYLNSLPPgvFSHLTA 527
Cdd:COG4886   228 TNLETLDLSNNQLTDL---------PELGNL-----------------------TNLEELDLSNNQLTDLPP--LANLTN 273

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561470 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDIT 577
Cdd:COG4886   274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR_8 pfam13855
Leucine rich repeat;
288-348 5.67e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561470 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-581 3.25e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  90 AFRNLPNLRILDLGSSKIYFLHPDA-----------------FQG------LFHLFELRLYFCGLSDAVLKD-GYFRNLK 145
Cdd:PLN00113   88 AIFRLPYIQTINLSNNQLSGPIPDDifttssslrylnlsnnnFTGsiprgsIPNLETLDLSNNMLSGEIPNDiGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 146 ALtrlDLSKNQIRSlYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEplQGKTLSFFSLAANSLYSRVSVDWGKCMNpfrn 225
Cdd:PLN00113  168 VL---DLGGNVLVG-KIPNSLTNLTSLEFLTLASNQLVGQIPRELG--QMKSLKWIYLGYNNLSGEIPYEIGGLTS---- 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 226 mvLEILDVSGNGWTVDITGNFSNaISKSQAFSLIlahhimgagfgfhnikdpdQNTFAGLARSSVR------HLDLSHGF 299
Cdd:PLN00113  238 --LNHLDLVYNNLTGPIPSSLGN-LKNLQYLFLY-------------------QNKLSGPIPPSIFslqkliSLDLSDNS 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 300 VFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLnlsynllgELYSSNFYG-LPKvayiDLQKNHiaiiqdq 378
Cdd:PLN00113  296 LSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--------QLWSNKFSGeIPK----NLGKHN------- 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 379 tfkfleKLQTLDLRDNALTTihfipSIPDIFLSGNKLVTL------------PKINLTANL--IHLSENRLE-------- 436
Cdd:PLN00113  357 ------NLTVLDLSTNNLTG-----EIPEGLCSSGNLFKLilfsnslegeipKSLGACRSLrrVRLQDNSFSgelpseft 425

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 437 NLDILYFL---------------LRVPHLQILILNQNRFSSCSGDQTPSENpsLEQLFLGENMLqlaweTELCWDVFEGL 501
Cdd:PLN00113  426 KLPLVYFLdisnnnlqgrinsrkWDMPSLQMLSLARNKFFGGLPDSFGSKR--LENLDLSRNQF-----SGAVPRKLGSL 498

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT---VLSHNDLPAnLEILDISRNQL---LAPNPDVFVSLSVLD 575
Cdd:PLN00113  499 SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgqiPASFSEMPV-LSQLDLSQNQLsgeIPKNLGNVESLVQVN 577


                  ....*.
gi 1034561470 576 ITHNKF 581
Cdd:PLN00113  578 ISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 328-581 7.54e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 7.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 328 ADEAFYGLDNLQVLNLSYNLLGELY----SSNFYGLPKVAYIDLQKNHIAIIQDQT------FKFLEKLQTLDLRDNALT 397
Cdd:cd00116    15 ATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 398 --TIHFIPSipdiFLSGNKLVTLpkinltanliHLSENRLENlDILYFLLRV-----PHLQILILNQNRFSSCSGDQTPS 470
Cdd:cd00116    95 pdGCGVLES----LLRSSSLQEL----------KLNNNGLGD-RGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEALAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 471 E---NPSLEQLFLGENMLQLAWETELCWDvFEGLSHLQVLYLNHNYLN----SLPPGVFSHLTALRGLSLNSNRLT---- 539
Cdd:cd00116   160 AlraNRDLKELNLANNGIGDAGIRALAEG-LKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTdaga 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034561470 540 --VLSHNDLPA-NLEILDISRNQL-------LAPNPDVFVSLSVLDITHNKF 581
Cdd:cd00116   239 aaLASALLSPNiSLLTLSLSCNDItddgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
95-182 5.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  95 PNLRILDLGSSKIYFLHPDAFQGlfhlfelrlyfcglsdavlkdgyfrnLKALTRLDLSKNQIRSLYLHpSFGKLNSLKS 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------LSNLKVLDLSNNLLTTLSPG-AFSGLPSLRY 53


                  ....*...
gi 1034561470 175 IDFSSNQI 182
Cdd:pfam13855  54 LDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 554-634 2.43e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  554 DISRNQLLAPNPDVF---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIyCVYPDSFSGVSLF--SLSTEG 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAL-CAGPGALAGQPLLgiPLLDSG 79


                   ....*.
gi 1034561470  629 CDEEEV 634
Cdd:TIGR00864   80 CDEEYV 85
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-630 4.73e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 4.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034561470  579 NKFICECELSTFINWLNHTNVTiaGPPADIYCVYPDSFSG-VSLFSLSTEGCD 630
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHL--QDPVDLRCASPSSLRGpLLELLHSEFKCP 51
LRR smart00370
Leucine-rich repeats, outliers;
501-524 2.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 1034561470  501 LSHLQVLYLNHNYLNSLPPGVFSH 524
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-208 8.27e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  89 EAFRNLPNLRILDLGSSKIyflHPDAFQGLF-------HLFELRLYFCGLSDAVLKD--GYFRNLKALTRLDLSKNQIRS 159
Cdd:cd00116   159 KALRANRDLKELNLANNGI---GDAGIRALAeglkancNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLTD 235

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034561470 160 ---LYLHPSFGKLN-SLKSIDFSSNQIFLV-CEHELEPLQGK-TLSFFSLAANSL 208
Cdd:cd00116   236 agaAALASALLSPNiSLLTLSLSCNDITDDgAKDLAEVLAEKeSLLELDLRGNKF 290
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 693-837 4.58e-37

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 136.73  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 693 YDAYLCFS-SKDFTWVQNALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:pfam01582   1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 772 FSYAQGRCLsDLNSALIMVVVGSLSQYQL-------MKHQSIRGFVQKQQYLRWPEDL------------QDVGWFLHKL 832
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154


                  ....*
gi 1034561470 833 SQQIL 837
Cdd:pfam01582 155 AYDIS 159
TIR smart00255
Toll - interleukin 1 - resistance;
692-827 4.81e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.02  E-value: 4.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  692 KYDAYLCFSSKDftWVQNALLKHLDTQYSdqnRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034561470  772 FSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKqQYLRWPEDLQDVGW 827
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-577 4.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 288 SSVRHLDLShgfvfslNSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886    96 TNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRV 447
Cdd:COG4886   167 SNNQLTDL-PEELGNLTNLKELDLSNNQIT------DLPEPLGNLTNLEEL----------DLSGNQLTDLPE--PLANL 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 448 PHLQILILNQNRFSSCsgdqtpsenPSLEQLflgenmlqlawetelcwdvfeglSHLQVLYLNHNYLNSLPPgvFSHLTA 527
Cdd:COG4886   228 TNLETLDLSNNQLTDL---------PELGNL-----------------------TNLEELDLSNNQLTDLPP--LANLTN 273

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561470 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDIT 577
Cdd:COG4886   274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-553 1.63e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 288 SSVRHLDLSHGFVFSLNSrVFETLKDLKVLNLAYNKINKIaDEAFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886   136 TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD---IFLSGNKLVTLPKINLTANL--IHLSENRLENLDILY 442
Cdd:COG4886   213 SGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNleeLDLSNNQLTDLPPLANLTNLktLDLSNNQLTDLKLKE 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 443 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVF 522
Cdd:COG4886   292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1034561470 523 SHLTALRGLSLNSNRLTVLSHNDLPANLEIL 553
Cdd:COG4886   372 LGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
309-560 3.31e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 309 ETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNllgelysSNFYGLPKVAYIDLQKNHIAIIqDQTFKFLEKLQT 388
Cdd:COG4886    69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 389 LDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRVPHLQILILNQNRFSScsGDQT 468
Cdd:COG4886   141 LDLSNNQLT------DLPEPLGNLTNLKSL----------DLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEP 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 469 PSENPSLEQLFLGENMLqlaweTELCwDVFEGLSHLQVLYLNHNYLNSLPpgVFSHLTALRGLSLNSNRLTVLSHNDLPA 548
Cdd:COG4886   201 LGNLTNLEELDLSGNQL-----TDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLT 272

                         250
                  ....*....|..
gi 1034561470 549 NLEILDISRNQL 560
Cdd:COG4886   273 NLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
291-552 6.52e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 291 RHLDLSHGFVFSLnSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDLQKN 370
Cdd:COG4886   162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 371 HIAIIQDqtFKFLEKLQTLDLRDNALTTIHF---IPSIPDIFLSGNKLVTLpkinltaNLIHLSENRLENLDILYFLLRV 447
Cdd:COG4886   239 QLTDLPE--LGNLTNLEELDLSNNQLTDLPPlanLTNLKTLDLSNNQLTDL-------KLKELELLLGLNSLLLLLLLLN 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 448 PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
Cdd:COG4886   310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389

                         250       260
                  ....*....|....*....|....*
gi 1034561470 528 LRGLSLNSNRLTVLSHNDLPANLEI 552
Cdd:COG4886   390 LLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-507 1.23e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 1.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  51 LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCG 130
Cdd:COG4886    28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 131 LsdavlkdgyFRNLKALTRLDLSKNQIRSLYlhPSFGKLNSLKSIDFSSNQIflvcEHELEPLQG-KTLSFFSLAANSLy 209
Cdd:COG4886   108 E---------LSNLTNLESLDLSGNQLTDLP--EELANLTNLKELDLSNNQL----TDLPEPLGNlTNLKSLDLSNNQL- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 210 SRVSVDWGKCMNpfrnmvLEILDVSGNGWTvditgNFSNAISKsqafslilahhimgagfgfhnikdpdqntfaglaRSS 289
Cdd:COG4886   172 TDLPEELGNLTN------LKELDLSNNQIT-----DLPEPLGN----------------------------------LTN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 290 VRHLDLSHGFVFSLnSRVFETLKDLKVLNLAYNKINKIADeaFYGLDNLQVLNLSYNLLGELysSNFYGLPKVAYIDLQK 369
Cdd:COG4886   207 LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSN 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 370 NHIAIIQdqtfkfLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPH 449
Cdd:COG4886   282 NQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034561470 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVL 507
Cdd:COG4886   356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-462 2.94e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 2.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  37 NLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGsskiyflHPDAFQ 116
Cdd:COG4886    38 LLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 117 GLFHLFELRLYFCGLSDAvlkDGYFRNLKALTRLDLSKNQIRSLylHPSFGKLNSLKSIDFSSNQIFLVCEhELEPLqgK 196
Cdd:COG4886   111 NLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNL--T 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 197 TLSFFSLAANSLySRVSVDWGKCMNpfrnmvLEILDVSGNgwtvDITgNFSNAISKSqafslilahhimgagfgfhnikd 276
Cdd:COG4886   183 NLKELDLSNNQI-TDLPEPLGNLTN------LEELDLSGN----QLT-DLPEPLANL----------------------- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 277 pdqntfaglarSSVRHLDLSHGFVFSLNSrvFETLKDLKVLNLAYNKINKIADEAfyGLDNLQVLNLSYNLLGELYSSNF 356
Cdd:COG4886   228 -----------TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 357 YGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLE 436
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                         410       420
                  ....*....|....*....|....*.
gi 1034561470 437 NLDILYFLLRVPHLQILILNQNRFSS 462
Cdd:COG4886   373 GLLEATLLTLALLLLTLLLLLLTTTA 398
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
337-581 5.50e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 5.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLV 416
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 417 TLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCsgDQTPSENPSLEQLFLGENMLqlaweTELcWD 496
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQL-----TDL-PE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 497 VFEGLSHLQVLYLNHNYLNSLPPgVFSHLTALRGLSLNSNRLTVLSH--NDLPaNLEILDISRNQLLAPNPDV--FVSLS 572
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEplGNLT-NLEELDLSGNQLTDLPEPLanLTNLE 231


                  ....*....
gi 1034561470 573 VLDITHNKF 581
Cdd:COG4886   232 TLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
288-348 5.67e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561470 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
314-372 5.90e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034561470 314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
473-538 3.78e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.78e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034561470 473 PSLEQLFLGENMLqlaweTELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538
Cdd:pfam13855   1 PNLRSLDLSNNRL-----TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 696-782 6.78e-10

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 57.33  E-value: 6.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 696 YLCFSSKDFTWVQnALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYA 775
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALE-----AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75


                  ....*..
gi 1034561470 776 QGRCLSD 782
Cdd:pfam13676  76 LADPEGR 82
LRR_8 pfam13855
Leucine rich repeat;
502-560 1.79e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.79e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561470 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL--PANLEILDISRNQL 560
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-581 3.25e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  90 AFRNLPNLRILDLGSSKIYFLHPDA-----------------FQG------LFHLFELRLYFCGLSDAVLKD-GYFRNLK 145
Cdd:PLN00113   88 AIFRLPYIQTINLSNNQLSGPIPDDifttssslrylnlsnnnFTGsiprgsIPNLETLDLSNNMLSGEIPNDiGSFSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 146 ALtrlDLSKNQIRSlYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEplQGKTLSFFSLAANSLYSRVSVDWGKCMNpfrn 225
Cdd:PLN00113  168 VL---DLGGNVLVG-KIPNSLTNLTSLEFLTLASNQLVGQIPRELG--QMKSLKWIYLGYNNLSGEIPYEIGGLTS---- 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 226 mvLEILDVSGNGWTVDITGNFSNaISKSQAFSLIlahhimgagfgfhnikdpdQNTFAGLARSSVR------HLDLSHGF 299
Cdd:PLN00113  238 --LNHLDLVYNNLTGPIPSSLGN-LKNLQYLFLY-------------------QNKLSGPIPPSIFslqkliSLDLSDNS 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 300 VFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLnlsynllgELYSSNFYG-LPKvayiDLQKNHiaiiqdq 378
Cdd:PLN00113  296 LSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--------QLWSNKFSGeIPK----NLGKHN------- 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 379 tfkfleKLQTLDLRDNALTTihfipSIPDIFLSGNKLVTL------------PKINLTANL--IHLSENRLE-------- 436
Cdd:PLN00113  357 ------NLTVLDLSTNNLTG-----EIPEGLCSSGNLFKLilfsnslegeipKSLGACRSLrrVRLQDNSFSgelpseft 425

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 437 NLDILYFL---------------LRVPHLQILILNQNRFSSCSGDQTPSENpsLEQLFLGENMLqlaweTELCWDVFEGL 501
Cdd:PLN00113  426 KLPLVYFLdisnnnlqgrinsrkWDMPSLQMLSLARNKFFGGLPDSFGSKR--LENLDLSRNQF-----SGAVPRKLGSL 498

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT---VLSHNDLPAnLEILDISRNQL---LAPNPDVFVSLSVLD 575
Cdd:PLN00113  499 SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgqiPASFSEMPV-LSQLDLSQNQLsgeIPKNLGNVESLVQVN 577


                  ....*.
gi 1034561470 576 ITHNKF 581
Cdd:PLN00113  578 ISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
383-580 4.44e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 4.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 383 LEKLQT-LDLRDNALTTI-HFIP-SIPDIFLSGNKLVTLPKiNLTANLIHLSENrlENLdilyfLLRVPH-----LQILI 454
Cdd:PRK15370  176 LKNNKTeLRLKILGLTTIpACIPeQITTLILDNNELKSLPE-NLQGNIKTLYAN--SNQ-----LTSIPAtlpdtIQEME 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 455 LNQNRFSscsgdQTPSENPS-LEQLFLGENMLQLAWETelcwdVFEGLSHLQVLylnHNYLNSLPpgvfSHL-TALRGLS 532
Cdd:PRK15370  248 LSINRIT-----ELPERLPSaLQSLDLFHNKISCLPEN-----LPEELRYLSVY---DNSIRTLP----AHLpSGITHLN 310

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034561470 533 LNSNRLTVLSHNdLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNK 580
Cdd:PRK15370  311 VQSNSLTALPET-LPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQ 357
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 328-581 7.54e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 7.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 328 ADEAFYGLDNLQVLNLSYNLLGELY----SSNFYGLPKVAYIDLQKNHIAIIQDQT------FKFLEKLQTLDLRDNALT 397
Cdd:cd00116    15 ATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 398 --TIHFIPSipdiFLSGNKLVTLpkinltanliHLSENRLENlDILYFLLRV-----PHLQILILNQNRFSSCSGDQTPS 470
Cdd:cd00116    95 pdGCGVLES----LLRSSSLQEL----------KLNNNGLGD-RGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEALAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 471 E---NPSLEQLFLGENMLQLAWETELCWDvFEGLSHLQVLYLNHNYLN----SLPPGVFSHLTALRGLSLNSNRLT---- 539
Cdd:cd00116   160 AlraNRDLKELNLANNGIGDAGIRALAEG-LKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTdaga 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034561470 540 --VLSHNDLPA-NLEILDISRNQL-------LAPNPDVFVSLSVLDITHNKF 581
Cdd:cd00116   239 aaLASALLSPNiSLLTLSLSCNDItddgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
337-396 2.62e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.62e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
490-583 4.20e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 4.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 490 ETELCWDVFeGLS--------HLQVLYLNHNYLNSLPPGVFSHLtalRGLSLNSNRLTVLSHNdLPANLEILDISRNQLL 561
Cdd:PRK15370  180 KTELRLKIL-GLTtipacipeQITTLILDNNELKSLPENLQGNI---KTLYANSNQLTSIPAT-LPDTIQEMELSINRIT 254

                          90       100
                  ....*....|....*....|..
gi 1034561470 562 APNPDVFVSLSVLDITHNKFIC 583
Cdd:PRK15370  255 ELPERLPSALQSLDLFHNKISC 276
LRR_8 pfam13855
Leucine rich repeat;
95-182 5.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  95 PNLRILDLGSSKIYFLHPDAFQGlfhlfelrlyfcglsdavlkdgyfrnLKALTRLDLSKNQIRSLYLHpSFGKLNSLKS 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------LSNLKVLDLSNNLLTTLSPG-AFSGLPSLRY 53


                  ....*...
gi 1034561470 175 IDFSSNQI 182
Cdd:pfam13855  54 LDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 498-580 6.93e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 498 FEGLSHLQVLYLNHNYLNSLPPgvFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQL-----LAPNPDVFVSLS 572
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLppgekLTFDPRSLAALS 119

                          90
                  ....*....|..
gi 1034561470 573 ----VLDITHNK 580
Cdd:cd21340   120 nslrVLNISGNN 131
LRR_8 pfam13855
Leucine rich repeat;
84-126 7.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 7.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034561470  84 LTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRL 126
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 292-439 1.12e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 292 HLDLSHGFVFSLNSrvFETLKDLKVLNLAYNKINKIadEAFYGLDNLQVLNLSYNLLGE------LYSSNFYGLPKVAYI 365
Cdd:cd21340    50 HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNSLRVL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 366 DLQKNHIAIIQDqtFKFLEKLQTLDLRDNALTTIHFI-------PSIPDIFLSGNKLVTLPKINltANLIhLSENRLENL 438
Cdd:cd21340   126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldllsswPSLRELDLTGNPVCKKPKYR--DKII-LASKSLEVL 200


                  .
gi 1034561470 439 D 439
Cdd:cd21340   201 D 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 408-581 1.48e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 408 IFLSGNKLVTLPKINLTANL--IHLSENRLENLDILYFLlrvPHLQILILNQNR------FSSCsgdqtpsenPSLEQLF 479
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLkvLYLYDNKITKIENLEFL---TNLTHLYLQNNQiekienLENL---------VNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 480 LGENMLQlawetelcwdVFEGL---SHLQVLYLNHNylnSLPPGVfshltalrGLSLNSNRLTVLSHNdlpanLEILDIS 556
Cdd:cd21340    75 LGGNRIS----------VVEGLenlTNLEELHIENQ---RLPPGE--------KLTFDPRSLAALSNS-----LRVLNIS 128

                         170       180
                  ....*....|....*....|....*.
gi 1034561470 557 RNQLLAPNP-DVFVSLSVLDITHNKF 581
Cdd:cd21340   129 GNNIDSLEPlAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 367-579 2.00e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 367 LQKNHIAIIQDqtFKFLEKLQTLDLRDNALTTIhfipsipdiflsgNKLVTLPkiNLTAnlIHLSEN---RLENLDILyf 443
Cdd:cd21340     9 LNDKNITKIDN--LSLCKNLKVLYLYDNKITKI-------------ENLEFLT--NLTH--LYLQNNqieKIENLENL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 444 llrvPHLQILILNQNRFSSCSGDQTPsenPSLEQLFLGENmlQLAWETELCWDVF--EGLSH-LQVLYLNHNYLNSLPPg 520
Cdd:cd21340    68 ----VNLKKLYLGGNRISVVEGLENL---TNLEELHIENQ--RLPPGEKLTFDPRslAALSNsLRVLNISGNNIDSLEP- 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034561470 521 vFSHLTalrglslnsnrltvlshndlpaNLEILDISRNQLLAPNPDVFV-----SLSVLDITHN 579
Cdd:cd21340   138 -LAPLR----------------------NLEQLDASNNQISDLEELLDLlsswpSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
360-415 2.23e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034561470 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH-----FIPSIPDIFLSGNKL 415
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 554-634 2.43e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  554 DISRNQLLAPNPDVF---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIyCVYPDSFSGVSLF--SLSTEG 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAL-CAGPGALAGQPLLgiPLLDSG 79


                   ....*.
gi 1034561470  629 CDEEEV 634
Cdd:TIGR00864   80 CDEEYV 85
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-630 4.73e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 4.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034561470  579 NKFICECELSTFINWLNHTNVTiaGPPADIYCVYPDSFSG-VSLFSLSTEGCD 630
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHL--QDPVDLRCASPSSLRGpLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 308-462 1.28e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 308 FETLKDLKVLNLAYNKINKIadEAFYGLDNLQVLNLSYNLLGELysSNFYGLPKVAYIDLQKNHIAIIQDqtFKFLEKLQ 387
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEG--LENLTNLE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 388 TLDLRDNAL---TTIHFIP-SIPDIF-------LSGNKLVTLPKINLTANLIHL--SENRLENL-DILYFLLRVPHLQIL 453
Cdd:cd21340    94 ELHIENQRLppgEKLTFDPrSLAALSnslrvlnISGNNIDSLEPLAPLRNLEQLdaSNNQISDLeELLDLLSSWPSLREL 173


                  ....*....
gi 1034561470 454 ILNQNRFSS 462
Cdd:cd21340   174 DLTGNPVCK 182
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 324-534 2.14e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.78  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  324 INKIADEAFYGLDNLQVLNLSYNLlGELYSSNFYGLPKV-AYIDLQKNHIAIIQDQT----FKFLEKLQTLDL------- 391
Cdd:PLN03210   680 LNKLEDLDMSRCENLEILPTGINL-KSLYRLNLSGCSRLkSFPDISTNISWLDLDETaieeFPSNLRLENLDElilcemk 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  392 ------RDNALTTIHFI--PSIPDIFLSGN-KLVTLPKI--NLTaNLIHLSENRLENLDILYFLLRVPHLQILilnqnRF 460
Cdd:PLN03210   759 seklweRVQPLTPLMTMlsPSLTRLFLSDIpSLVELPSSiqNLH-KLEHLEIENCINLETLPTGINLESLESL-----DL 832

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  461 SSCSGDQT-PSENPSLEQLFLGENMLQ-LAWETE----LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLN 534
Cdd:PLN03210   833 SGCSRLRTfPDISTNISDLNLSRTGIEeVPWWIEkfsnLSFLDMNGCNNLQRVSLNISKLKHLETVDFSDCGALTEASWN 912
LRR smart00370
Leucine-rich repeats, outliers;
501-524 2.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 1034561470  501 LSHLQVLYLNHNYLNSLPPGVFSH 524
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
501-524 2.97e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 1034561470  501 LSHLQVLYLNHNYLNSLPPGVFSH 524
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-208 8.27e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470  89 EAFRNLPNLRILDLGSSKIyflHPDAFQGLF-------HLFELRLYFCGLSDAVLKD--GYFRNLKALTRLDLSKNQIRS 159
Cdd:cd00116   159 KALRANRDLKELNLANNGI---GDAGIRALAeglkancNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLTD 235

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034561470 160 ---LYLHPSFGKLN-SLKSIDFSSNQIFLV-CEHELEPLQGK-TLSFFSLAANSL 208
Cdd:cd00116   236 agaAALASALLSPNiSLLTLSLSCNDITDDgAKDLAEVLAEKeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 288-400 8.82e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 8.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561470 288 SSVRHLDLSH-----GFVFSLNSRVFETLKD-LKVLNLAYNKINKIADeaFYGLDNLQVLNLSYNLLGELyssnfyglpk 361
Cdd:cd21340    90 TNLEELHIENqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL---------- 157

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034561470 362 vayidlqkNHIAiiqdQTFKFLEKLQTLDLRDNALTTIH 400
Cdd:cd21340   158 --------EELL----DLLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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