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Conserved domains on  [gi|1034554651|ref|XP_016855527|]
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tryptophan--tRNA ligase, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 1000926)

tryptophan--tRNA ligase is a class I tRNA synthetase and aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA

EC:  6.1.1.2
Gene Ontology:  GO:0006436|GO:0004830|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00927 super family cl35130
tryptophanyl-tRNA synthetase; Reviewed
 34-341 5.19e-109

tryptophanyl-tRNA synthetase; Reviewed


The actual alignment was detected with superfamily member PRK00927:

Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 321.27  E-value: 5.19e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 113
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYEC-FFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 114 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSS------PahgtssgsstrfqqevwgVLSSARV---HSQY 184
Cdd:PRK00927   80 QSHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSaglftyP------------------VLMAADIllyKADL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 185 VCVGV---------------FN--------------LASMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKA 235
Cdd:PRK00927  142 VPVGEdqkqhleltrdiarrFNnlygevfpvpepliPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDFT--SEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDH 311
Cdd:PRK00927  222 VTDSErlREIRYDLPNKPEVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAY 301

                         330       340       350
                  ....*....|....*....|....*....|
gi 1034554651 312 LEKVLQIGSAKAKELAYTVCQEVKKLVGFL 341
Cdd:PRK00927  302 LDEILAEGAEKARAVASKTLKEVREAMGLL 331
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 34-341 5.19e-109

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 321.27  E-value: 5.19e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 113
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYEC-FFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 114 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSS------PahgtssgsstrfqqevwgVLSSARV---HSQY 184
Cdd:PRK00927   80 QSHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSaglftyP------------------VLMAADIllyKADL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 185 VCVGV---------------FN--------------LASMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKA 235
Cdd:PRK00927  142 VPVGEdqkqhleltrdiarrFNnlygevfpvpepliPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDFT--SEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDH 311
Cdd:PRK00927  222 VTDSErlREIRYDLPNKPEVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAY 301

                         330       340       350
                  ....*....|....*....|....*....|
gi 1034554651 312 LEKVLQIGSAKAKELAYTVCQEVKKLVGFL 341
Cdd:PRK00927  302 LDEILAEGAEKARAVASKTLKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 33-341 3.08e-102

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 303.89  E-value: 3.08e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILF 112
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYEC-FFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 113 QQSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSSPAhgtssgsstrfqqevwG-----VLSSARV---HSQY 184
Cdd:COG0180    81 VQSDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENVNA----------------GlltypVLMAADIllyKADL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 185 VCVGV---------------FN--------------LASMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKA 235
Cdd:COG0180   145 VPVGEdqkqhleltrdiarrFNhrygevfpepealiPEEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSA 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDfTSEVTYDPAGRAGVSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHL 312
Cdd:COG0180   221 VTD-SERLRYDDPGKPEVCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAEL 299

                         330       340
                  ....*....|....*....|....*....
gi 1034554651 313 EKVLQIGSAKAKELAYTVCQEVKKLVGFL 341
Cdd:COG0180   300 DEILAEGAEKARAIAAKTLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 36-293 4.38e-82

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 250.58  E-value: 4.38e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSILFQQ 114
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEAGYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 115 SQVSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwggsSPAHGTSSGSSTRFqqeVWGVLSSARV-HSQ--YVCVGV-- 189
Cdd:cd00806    81 SDVPEHYELAWLLSCVVTFGELERMTGFK----------DKSAQGESVNIGLL---TYPVLQAADIlLYKacLVPVGIdq 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 190 -------------FN-------------LASMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEV 243
Cdd:cd00806   148 dphleltrdiarrFNklygeifpkpaalLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTE 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034554651 244 TYDPAGRAGVSNIVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 293
Cdd:cd00806   226 HRRDGGGPGVSNLVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 33-340 1.73e-59

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 194.09  E-value: 1.73e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVlYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSIL 111
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELF-ICIADLHAITVKQtDPDALRKAREELAADYLAVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 112 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwgGSSPAHGTSSGSST-------------------------- 165
Cdd:TIGR00233  80 FLQSDYPEHYELAWLLSCQVTFGELKRMTQFK--------DKSQAENVPIGLLSypvlqaadillyqadlvpvgidqdqh 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 166 ---------RFQQEVWGVLS-SARVHSQyvcvgvfnlaSMKKVKSLRDpsAKMSKSDPDklATVRITDSPEEIVQKFRKA 235
Cdd:TIGR00233 152 leltrdlaeRFNKKFKNFFPkPESLISK----------FFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKA 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDFTSEVTYDPAGRAGVSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLD 308
Cdd:TIGR00233 218 ATDGGRVTLFEHREKPGVPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIA 295

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1034554651 309 KDHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 340
Cdd:TIGR00233 296 EEILDKILEPGAKKARETANKTLADVYKAMGL 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
30-296 8.30e-37

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 133.94  E-value: 8.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  30 QKDSKKRVFSGIQPTGILHLGnYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAV---LRQSILDMTAV---LLACG 103
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPerkLLSRETVLENAikaQLACG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 104 INPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWK-VHTRSCWGGSSPAHGTS-----SGSSTRFQQEV------ 171
Cdd:pfam00579  80 LDPEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKdVKKRLEQGPGISLGEFTypllqAYDILLLKADLqpggsd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 172 -WGVLSSARvHSQYvcvgVFNLASMKKVKSL-------RDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSEV 243
Cdd:pfam00579 160 qWGNIELGR-DLAR----RFNKKIFKKPVGLtnplltgLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDREV 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034554651 244 TYDPAGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 296
Cdd:pfam00579 233 RKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
 
Name Accession Description Interval E-value
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 34-341 5.19e-109

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 321.27  E-value: 5.19e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 113
Cdd:PRK00927    1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYEC-FFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 114 QSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSS------PahgtssgsstrfqqevwgVLSSARV---HSQY 184
Cdd:PRK00927   80 QSHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSaglftyP------------------VLMAADIllyKADL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 185 VCVGV---------------FN--------------LASMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKA 235
Cdd:PRK00927  142 VPVGEdqkqhleltrdiarrFNnlygevfpvpepliPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKA 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDFT--SEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDH 311
Cdd:PRK00927  222 VTDSErlREIRYDLPNKPEVSNLLTIYSALSGESIEELEAeyEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAY 301

                         330       340       350
                  ....*....|....*....|....*....|
gi 1034554651 312 LEKVLQIGSAKAKELAYTVCQEVKKLVGFL 341
Cdd:PRK00927  302 LDEILAEGAEKARAVASKTLKEVREAMGLL 331
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 33-341 3.08e-102

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 303.89  E-value: 3.08e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILF 112
Cdd:COG0180     2 SKKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYEC-FFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 113 QQSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRSCWGGSSPAhgtssgsstrfqqevwG-----VLSSARV---HSQY 184
Cdd:COG0180    81 VQSDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENVNA----------------GlltypVLMAADIllyKADL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 185 VCVGV---------------FN--------------LASMKKVKSLrDPSAKMSKSDpdkLATVRITDSPEEIVQKFRKA 235
Cdd:COG0180   145 VPVGEdqkqhleltrdiarrFNhrygevfpepealiPEEGARIPGL-DGRKKMSKSY---GNTINLLDDPKEIRKKIKSA 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDfTSEVTYDPAGRAGVSNIVAVHAAVTG-LSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHL 312
Cdd:COG0180   221 VTD-SERLRYDDPGKPEVCNLFTIYSAFSGkEEVEELEAeyRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAEL 299

                         330       340
                  ....*....|....*....|....*....
gi 1034554651 313 EKVLQIGSAKAKELAYTVCQEVKKLVGFL 341
Cdd:COG0180   300 DEILAEGAEKARAIAAKTLAEVREAMGLL 328
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 36-293 4.38e-82

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 250.58  E-value: 4.38e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSILFQQ 114
Cdd:cd00806     1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEAGYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 115 SQVSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwggsSPAHGTSSGSSTRFqqeVWGVLSSARV-HSQ--YVCVGV-- 189
Cdd:cd00806    81 SDVPEHYELAWLLSCVVTFGELERMTGFK----------DKSAQGESVNIGLL---TYPVLQAADIlLYKacLVPVGIdq 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 190 -------------FN-------------LASMKKVKSLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKAVTDFTSEV 243
Cdd:cd00806   148 dphleltrdiarrFNklygeifpkpaalLSKGAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAATDGGRTE 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034554651 244 TYDPAGRAGVSNIVAVHAAVTGLSVEEVVR----RSAGMNTARYKLAVADAVIE 293
Cdd:cd00806   226 HRRDGGGPGVSNLVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQE 279
PLN02886 PLN02886
aminoacyl-tRNA ligase
 23-341 4.13e-73

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 231.24  E-value: 4.13e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  23 SAAAPALQKDS------KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMT 96
Cdd:PLN02886   29 ATAATAPEKEAppkvarKKRVVSGVQPTGSIHLGNYLGAIKNWVALQETYDT-FFCVVDLHAITLPHDPRELGKATRSTA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  97 AVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRScwggsspaHGTSSGSSTRFqqeVWGVLS 176
Cdd:PLN02886  108 AIYLACGIDPSKASVFVQSHVPAHAELMWLLSCSTPIGWLNKMIQFKEKSRK--------AGDENVGVGLL---TYPVLM 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 177 SARV---HSQYVCVG----------------VFNLASMKKVK-------------------------SLRDPSAKMSKSD 212
Cdd:PLN02886  177 ASDIllyQADLVPVGedqkqhleltrdiaerVNNLYGGRKWKklggrggsvfkvpealippagarvmSLTDGTSKMSKSA 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 213 PDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVI 292
Cdd:PLN02886  257 PSDQSRINLLDPPDVIANKIKRCKTDSFPGLEFDNPERPECNNLLSIYQLVTGKTKEEVLAECGDMRWGDFKPLLTDALI 336

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1034554651 293 EKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 341
Cdd:PLN02886  337 EHLSPIQVRYEEIMSDPSYLDSVLKEGADAAAEIADRTLANVYQAMGFV 385
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 33-340 1.73e-59

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 194.09  E-value: 1.73e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVlYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSIL 111
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELF-ICIADLHAITVKQtDPDALRKAREELAADYLAVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 112 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwgGSSPAHGTSSGSST-------------------------- 165
Cdd:TIGR00233  80 FLQSDYPEHYELAWLLSCQVTFGELKRMTQFK--------DKSQAENVPIGLLSypvlqaadillyqadlvpvgidqdqh 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 166 ---------RFQQEVWGVLS-SARVHSQyvcvgvfnlaSMKKVKSLRDpsAKMSKSDPDklATVRITDSPEEIVQKFRKA 235
Cdd:TIGR00233 152 leltrdlaeRFNKKFKNFFPkPESLISK----------FFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKA 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 236 VTDFTSEVTYDPAGRAGVSNIVAVHAAVT-----GLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEklKLD 308
Cdd:TIGR00233 218 ATDGGRVTLFEHREKPGVPNLLVIYQYLSfflidDDKLKEIYEayKSGKLGYGECKKALIEVLQEFLKEIQERRA--EIA 295

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1034554651 309 KDHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 340
Cdd:TIGR00233 296 EEILDKILEPGAKKARETANKTLADVYKAMGL 327
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 33-339 5.50e-38

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 138.06  E-value: 5.50e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYsIVDLHSIT-VPQDPAVLRQSILDMTAVLLACGINPEKSIL 111
Cdd:PRK12282    1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVL-IADQQALTdNAKNPEKIRRNILEVALDYLAVGIDPAKSTI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 112 FQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHTRscwggsspAHGTSSGSSTRFQqeVWGVLSSARV---HSQYVCVG 188
Cdd:PRK12282   80 FIQSQIPELAELTMYYMNLVTVARLERNPTVKTEIA--------QKGFGRSIPAGFL--TYPVSQAADItafKATLVPVG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 189 ---------------VFN--------------LASMKKVKSLrDPSAKMSKSDPDKLAtvrITDSPEEIVQKFRKAVTDf 239
Cdd:PRK12282  150 ddqlpmieqtreivrRFNslygtdvlvepealLPEAGRLPGL-DGKAKMSKSLGNAIY---LSDDADTIKKKVMSMYTD- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 240 TSEVTYDPAGRAGVSNIVAVHAAV--TGLSVEEVVR--RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKV 315
Cdd:PRK12282  225 PNHIRVEDPGKVEGNVVFTYLDAFdpDKAEVAELKAhyQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEI 304

                         330       340
                  ....*....|....*....|....
gi 1034554651 316 LQIGSAKAKELAYTVCQEVKKLVG 339
Cdd:PRK12282  305 LKAGSEKAREVAAQTLSEVKDAMG 328
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
30-296 8.30e-37

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 133.94  E-value: 8.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  30 QKDSKKRVFSGIQPTGILHLGnYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAV---LRQSILDMTAV---LLACG 103
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPerkLLSRETVLENAikaQLACG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 104 INPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWK-VHTRSCWGGSSPAHGTS-----SGSSTRFQQEV------ 171
Cdd:pfam00579  80 LDPEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKdVKKRLEQGPGISLGEFTypllqAYDILLLKADLqpggsd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 172 -WGVLSSARvHSQYvcvgVFNLASMKKVKSL-------RDPSAKMSKSDPdkLATVRITDSPEEIVQKFRKAVTDFTSEV 243
Cdd:pfam00579 160 qWGNIELGR-DLAR----RFNKKIFKKPVGLtnplltgLDGGKKMSKSAG--NSAIFLDDDPESVYKKIQKAYTDPDREV 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034554651 244 TYDPAGRAGVSN-IVAVHAAVTGLSV---------EEVVRRSAGMNtarYKLAVADAVIEKFA 296
Cdd:pfam00579 233 RKDLKLFTFLSNeEIEILEAELGKSPyreaeellaREVTGLVHGGD---LKKAAAEAVNKLLQ 292
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 32-340 3.44e-30

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 117.13  E-value: 3.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  32 DSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSV-LYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSI 110
Cdd:PRK12556    1 MSEKIMLTGIKPTGYPHLGNYIGAIKPALQMAKNYEGKaLYFIADYHALNAVHDPEQFRSYTREVAATWLSLGLDPEDVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 111 LFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKVHT-RSCWGGSSPAHGTSSGSSTR----------FQQEVWGVlssAR 179
Cdd:PRK12556   81 FYRQSDVPEIFELAWILSCLTPKGLMNRAHAYKAKVdQNKEAGLDLDAGVNMGLYTYpilmaadillFQATHVPV---GK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 180 VHSQYV-----CVGVFN-----LASMKKVkSLRDPSA--------KMSKSDPDklaTVRITDSPEEIVQKFRKAVTDFT- 240
Cdd:PRK12556  158 DQIQHIeiardIATYFNhtfgdTFTLPEY-VIQEEGAilpgldgrKMSKSYGN---VIPLFAEQEKLRKLIFKIKTDSSl 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 241 SEVTYDPAGragvSNIVAVHAA-VTGLSVEEV-VRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQI 318
Cdd:PRK12556  234 PNEPKDPET----SALFTIYKEfATEEEVQSMrEKYETGIGWGDVKKELFRVVDRELAGPREKYAMYMNEPSLLDEALEK 309

                         330       340
                  ....*....|....*....|..
gi 1034554651 319 GSAKAKELAYTVCQEVKKLVGF 340
Cdd:PRK12556  310 GAERAREIAKPNLAEIKKAIGF 331
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 33-133 2.29e-27

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 110.81  E-value: 2.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSvLYSIVDLHSITVP-QDPAVLRQSILDMTAVLLACGINPEKSIL 111
Cdd:PRK12283    1 FPDRVLSGMRPTGRLHLGHYHGVLKNWVKLQHEYEC-FFFVADWHALTTHyETPEVIEKNVWDMVIDWLAAGVDPAQATL 79

                          90       100
                  ....*....|....*....|..
gi 1034554651 112 FQQSQVSEHTQLSWILSCMVRL 133
Cdd:PRK12283   80 FIQSKVPEHAELHLLLSMITPL 101
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 36-129 4.78e-18

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 84.29  E-value: 4.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  36 RVFSGIQPTGILHLGNYLGAIESWVR--LQDEYDSvLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQ 113
Cdd:PRK12284    4 RVLTGITTTGTPHLGNYAGAIRPAIAasRQPGVES-FYFLADYHALIKCDDPARIQRSTLEIAATWLAAGLDPERVTFYR 82

                          90
                  ....*....|....*.
gi 1034554651 114 QSQVSEHTQLSWILSC 129
Cdd:PRK12284   83 QSDIPEIPELTWLLTC 98
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 37-293 8.93e-14

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 70.41  E-value: 8.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651  37 VFSGIQPTG-ILHLGNYLGaIESWVRLQDEYDSVLYSIVDLHSITV----------PQDPAVLRQSILDMTAVLLACGI- 104
Cdd:cd00395     2 LYCGIDPTAdSLHIGHLIG-LLTFRRFQHAGHRPIFLIGGQTGIIGdpsgkksertLNDPEEVRQNIRRIAAQYLAVGIf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 105 -NPEKSILFQQSQV---SEHTQLSWILSCMVRLPRLQHLHQWKvhtrscwggSSPAHGTSSGSSTRFQQEVWGVLSSARV 180
Cdd:cd00395    81 eDPTQATLFNNSDWpgpLAHIQFLRDLGKHVYVNYMERKTSFQ---------SRSEEGISATEFTYPPLQAADFLLLNTT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554651 181 HSQYVCVG--------VFNLASMKKVKSLRDPSA------------KMSKSDPDKLATVRITDSPEEIVQKFRKAVtdft 240
Cdd:cd00395   152 EGCDIQPGgsdqwgniTLGRELARRFNGFTIAEGltiplvtkldgpKFGKSESGPKWLDTEKTSPYEFYQFWINAV---- 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034554651 241 sevtydpagragVSNIVAVHAAVTGLSVEEVVRRSAGMNTAR----YKLAVADAVIE 293
Cdd:cd00395   228 ------------DSDVINILKYFTFLSKEEIERLEQEQYEAPgyrvAQKTLAEEVTK 272
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 200-235 2.74e-04

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 42.16  E-value: 2.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034554651 200 SLRDPSAKMSKSDPDklATVRITDSPEEIVQKFRKA 235
Cdd:PRK08560  207 GLDGGGIKMSKSKPG--SAIFVHDSPEEIRRKIKKA 240
nt_trans cd02156
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 37-103 5.48e-04

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


Pssm-ID: 173912 [Multi-domain]  Cd Length: 105  Bit Score: 39.06  E-value: 5.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034554651  37 VFSGIQPtGILHLGNYLGaIESWVRLQDEydsVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACG 103
Cdd:cd02156     2 ARFPGEP-GYLHIGHAKL-ICRAKGIADQ---CVVRIDDNPPVKVWQDPHELEERKESIEEDISVCG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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