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Conserved domains on  [gi|1002604396|ref|XP_015681414|]
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LOW QUALITY PROTEIN: laminin subunit alpha-5, partial [Protobothrops mucrosquamatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_B pfam00052
Laminin B (Domain IV);
941-1077 4.34e-42

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 150.88  E-value: 4.34e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396  941 YWHAPSSYLGDQVSSYAGYLKYELHSDIQRGDVfiPMESWADVILKGNQMSIMFVED--SYPTPGEVYNGELQLLEGNFK 1018
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPdqPPPDPGQEQTYSVRLHEENWR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002604396 1019 HTeTHNPVSREELMMVLANLEQLQIRALFSPISSSVSLHRVILERTTETHGSVQANSVE 1077
Cdd:pfam00052   79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
Laminin_I super family cl26988
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1439-1681 9.43e-19

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06008:

Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 87.85  E-value: 9.43e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1439 LKSLNTTSIAWARLHSINGSMQTITSQVRDYQRFIYKVRQNADELEEENADFVQDLNALQHKATMTHRKANSLMDVTQET 1518
Cdd:pfam06008    1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1519 FQLAESLVRNVTKIQNNINDLIHLMNTfTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQSAIAVEERDELKS--KE 1596
Cdd:pfam06008   81 LGHAKELAEAIKNLIDNIKEINEKVAT-LGENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDllSR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1597 MEKQYGTIQATLR----MAKDSLGKISEHLQTIIKAKEE-------SEKLLAQLDGARYPLSEKVKEytLASNKIQKVEL 1665
Cdd:pfam06008  160 IQTWFQSPQEENKalanALRDSLAEYEAKLSDLRELLREaaaktrdANRLNLANQANLREFQRKKEE--VSEQKNQLEET 237

                          250
                   ....*....|....*.
gi 1002604396 1666 AEQHANLLDELARNLS 1681
Cdd:pfam06008  238 LKTARDSLDAANLLLQ 253
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 829-877 7.83e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 64.30  E-value: 7.83e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396  829 CDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFSLDASNPKGC 877
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 690-738 1.61e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.53  E-value: 1.61e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396  690 CHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFPNCRPCDC 738
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1271-1317 4.17e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 4.17e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1002604396 1271 ECNCLSCGTDSCDPKTGQCRCKPGVTGQHCDRCQEGYYGYETCLGCQ 1317
Cdd:pfam00053    2 DCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 780-831 4.79e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 4.79e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1002604396  780 CNCSNSGIQDHTepgCNIESGQCQCKPNIVGRQCDLCAPGYYGYPNCRACDC 831
Cdd:pfam00053    1 CDCNPHGSLSDT---CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1319-1366 1.43e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.75  E-value: 1.43e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1319 CDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDGCSKC 1366
Cdd:pfam00053    1 CDCNpHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1111-1152 6.66e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 6.66e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1002604396 1111 PCDCNGH---SDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNSS 1152
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1217-1270 3.49e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 3.49e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1002604396 1217 PCDCSGNADPNmlfSDCNTLTGVCTgCMYNTAGARCEICAAGFYGDAVVAKNCT 1270
Cdd:cd00055      1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1162-1215 8.31e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 47.35  E-value: 8.31e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002604396 1162 CPCPLSVPSN---NFATGciykgsttQCLCKPGYAGFSCERCAPGYYGNPLVIGSSC 1215
Cdd:pfam00053    1 CDCNPHGSLSdtcDPETG--------QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 34-86 1.12e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002604396   34 SCQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFNLESgNYFGCK 86
Cdd:cd00055      1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 88-126 1.01e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.57  E-value: 1.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002604396   88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1-32 1.37e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1002604396    1 GSCECRAFVEGEACDKCKPLYWNLTPDNPFGC 32
Cdd:pfam00053   18 GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_B pfam00052
Laminin B (Domain IV);
941-1077 4.34e-42

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 150.88  E-value: 4.34e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396  941 YWHAPSSYLGDQVSSYAGYLKYELHSDIQRGDVfiPMESWADVILKGNQMSIMFVED--SYPTPGEVYNGELQLLEGNFK 1018
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPdqPPPDPGQEQTYSVRLHEENWR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002604396 1019 HTeTHNPVSREELMMVLANLEQLQIRALFSPISSSVSLHRVILERTTETHGSVQANSVE 1077
Cdd:pfam00052   79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
LamB smart00281
Laminin B domain;
937-1062 1.09e-36

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 135.08  E-value: 1.09e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396   937 FQELYWHAPSSYLGDQVSSYAGYLKYELHSDIQRGDVFIpmeSWADVILKGNQMSIMFVEDSYPTPGEVYNGELQLLEGN 1016
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHV---SAPDVILEGNGLRISHPAEGPPLPDELTTVEVRFREEN 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 1002604396  1017 FKHtETHNPVSREELMMVLANLEQLQIRALFSPISSSVSLHRVILE 1062
Cdd:smart00281   79 WQY-YGGRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLE 123
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1439-1681 9.43e-19

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 87.85  E-value: 9.43e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1439 LKSLNTTSIAWARLHSINGSMQTITSQVRDYQRFIYKVRQNADELEEENADFVQDLNALQHKATMTHRKANSLMDVTQET 1518
Cdd:pfam06008    1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1519 FQLAESLVRNVTKIQNNINDLIHLMNTfTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQSAIAVEERDELKS--KE 1596
Cdd:pfam06008   81 LGHAKELAEAIKNLIDNIKEINEKVAT-LGENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDllSR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1597 MEKQYGTIQATLR----MAKDSLGKISEHLQTIIKAKEE-------SEKLLAQLDGARYPLSEKVKEytLASNKIQKVEL 1665
Cdd:pfam06008  160 IQTWFQSPQEENKalanALRDSLAEYEAKLSDLRELLREaaaktrdANRLNLANQANLREFQRKKEE--VSEQKNQLEET 237

                          250
                   ....*....|....*.
gi 1002604396 1666 AEQHANLLDELARNLS 1681
Cdd:pfam06008  238 LKTARDSLDAANLLLQ 253
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 829-877 7.83e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 64.30  E-value: 7.83e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396  829 CDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFSLDASNPKGC 877
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 690-738 1.61e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.53  E-value: 1.61e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396  690 CHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFPNCRPCDC 738
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 689-731 2.52e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.06  E-value: 2.52e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1002604396  689 PCHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFP 731
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1271-1317 4.17e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 4.17e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1002604396 1271 ECNCLSCGTDSCDPKTGQCRCKPGVTGQHCDRCQEGYYGYETCLGCQ 1317
Cdd:pfam00053    2 DCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 780-831 4.79e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 4.79e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1002604396  780 CNCSNSGIQDHTepgCNIESGQCQCKPNIVGRQCDLCAPGYYGYPNCRACDC 831
Cdd:pfam00053    1 CDCNPHGSLSDT---CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1272-1310 7.84e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.48  E-value: 7.84e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1002604396  1272 CNCLSCGT--DSCDPKTGQCRCKPGVTGQHCDRCQEGYYGY 1310
Cdd:smart00180    1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGD 41
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1272-1317 8.99e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 8.99e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1272 CNCLSCGT--DSCDPKTGQCRCKPGVTGQHCDRCQEGYYGY-ETCLGCQ 1317
Cdd:cd00055      2 CDCNGHGSlsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 828-878 1.23e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.13  E-value: 1.23e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1002604396  828 ACDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFSlDASNPKGCT 878
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1319-1366 1.43e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.75  E-value: 1.43e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1319 CDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDGCSKC 1366
Cdd:pfam00053    1 CDCNpHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1319-1363 2.64e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 2.64e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1002604396  1319 CDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDGC 1363
Cdd:smart00180    1 CDCDpGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
690-731 3.08e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 3.08e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1002604396   690 CHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFP 731
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
829-877 1.09e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 1.09e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1002604396   829 CDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFsldASNPKGC 877
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
780-824 1.17e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 1.17e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1002604396   780 CNCSNSGiqdHTEPGCNIESGQCQCKPNIVGRQCDLCAPGYYGYP 824
Cdd:smart00180    1 CDCDPGG---SASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 780-824 1.46e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 1.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1002604396  780 CNCSNSGIQDHTepgCNIESGQCQCKPNIVGRQCDLCAPGYYGYP 824
Cdd:cd00055      2 CDCNGHGSLSGQ---CDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1318-1362 2.31e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 2.31e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1002604396 1318 RCDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDG 1362
Cdd:cd00055      1 PCDCNgHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1111-1152 6.66e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 6.66e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1002604396 1111 PCDCNGH---SDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNSS 1152
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1112-1156 3.05e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.20  E-value: 3.05e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1002604396 1112 CDCNGH---SDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNSSLEGN 1156
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1217-1270 3.49e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 3.49e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1002604396 1217 PCDCSGNADPNmlfSDCNTLTGVCTgCMYNTAGARCEICAAGFYGDAVVAKNCT 1270
Cdd:cd00055      1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1162-1215 8.31e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 47.35  E-value: 8.31e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002604396 1162 CPCPLSVPSN---NFATGciykgsttQCLCKPGYAGFSCERCAPGYYGNPLVIGSSC 1215
Cdd:pfam00053    1 CDCNPHGSLSdtcDPETG--------QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 34-86 1.12e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002604396   34 SCQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFNLESgNYFGCK 86
Cdd:cd00055      1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1112-1151 1.66e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.15  E-value: 1.66e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1002604396  1112 CDCNG---HSDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNS 1151
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 35-85 2.24e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.24e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1002604396   35 CQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFNLESGNYFGC 85
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1422-1681 3.76e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 3.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1422 LEDLQKIDSDFPALEHQLKSLNttsiawarlhsinGSMQTITSQVRDYQRFIYKVRQNADELEEEnadfVQDLNALQHKA 1501
Cdd:PRK03918   230 VKELEELKEEIEELEKELESLE-------------GSKRKLEEKIRELEERIEELKKEIEELEEK----VKELKELKEKA 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1502 TmTHRKANSLMDVTQETFQLAESLVRNVTKIQNNINDLIhlmntfTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQ 1581
Cdd:PRK03918   293 E-EYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERI------KELEEKEERLEELKKKLKELEKRLEELEERHELYE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1582 SAIAVEER-DELKSKEMEKqygtiqatlrmakdSLGKISEHLQTIIKAKEESEKLLAQLDGARYPLSEKVKEYTLASNKI 1660
Cdd:PRK03918   366 EAKAKKEElERLKKRLTGL--------------TPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1002604396 1661 QKV---------ELAEQH-ANLLDELARNLS 1681
Cdd:PRK03918   432 KKAkgkcpvcgrELTEEHrKELLEEYTAELK 462
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1162-1208 4.74e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.99  E-value: 4.74e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1002604396  1162 CPCPlsvPSNNFATGCIYKgsTTQCLCKPGYAGFSCERCAPGYYGNP 1208
Cdd:smart00180    1 CDCD---PGGSASGTCDPD--TGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1185-1216 8.21e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.65  E-value: 8.21e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1002604396 1185 QCLCKPGYAGFSCERCAPGYYGNPLvIGSSCQ 1216
Cdd:cd00055     20 QCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1218-1263 1.27e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.88  E-value: 1.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1002604396 1218 CDCSGNADPNmlfSDCNTLTGVCTgCMYNTAGARCEICAAGFYGDA 1263
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
35-76 1.45e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.84  E-value: 1.45e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1002604396    35 CQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFN 76
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 88-126 1.01e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.57  E-value: 1.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002604396   88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1-32 1.37e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1002604396    1 GSCECRAFVEGEACDKCKPLYWNLTPDNPFGC 32
Cdd:pfam00053   18 GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1473-1668 1.77e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1473 IYKVRQNADELEEENADFVQDLNALQHKATMTHRKANSLMDVTQETFQLAESLVRNVTKIQNNINDLIHLM--------- 1543
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELgeraralyr 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1544 ----NTFTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQSAiaveeRDELKSKEMEkqygtIQATLRMAKDSLGKIS 1619
Cdd:COG3883     98 sggsVSYLDVLLGSESFSDFLDRLSALSKIADADADLLEELKAD-----KAELEAKKAE-----LEAKLAELEALKAELE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1620 EHLQTIIKAKEESEKLLAQLDGARYPLSEKVKEYTLASNKIQKVELAEQ 1668
Cdd:COG3883    168 AAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
88-126 2.36e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.37  E-value: 2.36e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1002604396    88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 88-126 6.06e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.26  E-value: 6.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002604396   88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1217-1262 2.19e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.68  E-value: 2.19e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1002604396  1217 PCDCSGNADPnmlfsDCNTLTGVCTgCMYNTAGARCEICAAGFYGD 1262
Cdd:smart00180    2 DCDPGGSASG-----TCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
 1430-1625 2.43e-03

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 41.24  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1430 SDFPALEHQLKSLNTTSIAWarLHSINGSMQTITSQVRDY----QRFIYKVRQNADELEEEN----ADFVQDLNALQHKA 1501
Cdd:cd21116     30 DLLPSLNTHQALARAHALEW--LNEIKPKLLSLPNDIIGYnntfQSYYPDLIELADNLIKGDqgakQQLLQGLEALQSQV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1502 TMTHRKANSLMDVTQETFQLAESLVRNVTKIQNNIND-------LIHLMNTFTTANTSSTSAeefrqkiaeVDAMLRHMK 1574
Cdd:cd21116    108 TKKQTSVTSFINELTTFKNDLDDDSRNLQTDATKAQAqvavlnaLKNQLNSLAEQIDAAIDA---------LEKLSNDWQ 178

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1002604396 1575 AMDFSFQSAIaveerDELKSKEMEKQYGTIQATLRMAKDSLGKISEHLQTI 1625
Cdd:cd21116    179 TLDSDIKELI-----TDLEDAESSIDAAFLQADLKAAKADWNQLYEQAKSL 224
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1-33 7.96e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 7.96e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1002604396    1 GSCECRAFVEGEACDKCKPLYWNLtPDNPFGCT 33
Cdd:cd00055     19 GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
 
Name Accession Description Interval E-value
Laminin_B pfam00052
Laminin B (Domain IV);
941-1077 4.34e-42

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 150.88  E-value: 4.34e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396  941 YWHAPSSYLGDQVSSYAGYLKYELHSDIQRGDVfiPMESWADVILKGNQMSIMFVED--SYPTPGEVYNGELQLLEGNFK 1018
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPdqPPPDPGQEQTYSVRLHEENWR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002604396 1019 HTeTHNPVSREELMMVLANLEQLQIRALFSPISSSVSLHRVILERTTETHGSVQANSVE 1077
Cdd:pfam00052   79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
LamB smart00281
Laminin B domain;
937-1062 1.09e-36

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 135.08  E-value: 1.09e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396   937 FQELYWHAPSSYLGDQVSSYAGYLKYELHSDIQRGDVFIpmeSWADVILKGNQMSIMFVEDSYPTPGEVYNGELQLLEGN 1016
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHV---SAPDVILEGNGLRISHPAEGPPLPDELTTVEVRFREEN 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 1002604396  1017 FKHtETHNPVSREELMMVLANLEQLQIRALFSPISSSVSLHRVILE 1062
Cdd:smart00281   79 WQY-YGGRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLE 123
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1439-1681 9.43e-19

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 87.85  E-value: 9.43e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1439 LKSLNTTSIAWARLHSINGSMQTITSQVRDYQRFIYKVRQNADELEEENADFVQDLNALQHKATMTHRKANSLMDVTQET 1518
Cdd:pfam06008    1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1519 FQLAESLVRNVTKIQNNINDLIHLMNTfTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQSAIAVEERDELKS--KE 1596
Cdd:pfam06008   81 LGHAKELAEAIKNLIDNIKEINEKVAT-LGENDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDllSR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1597 MEKQYGTIQATLR----MAKDSLGKISEHLQTIIKAKEE-------SEKLLAQLDGARYPLSEKVKEytLASNKIQKVEL 1665
Cdd:pfam06008  160 IQTWFQSPQEENKalanALRDSLAEYEAKLSDLRELLREaaaktrdANRLNLANQANLREFQRKKEE--VSEQKNQLEET 237

                          250
                   ....*....|....*.
gi 1002604396 1666 AEQHANLLDELARNLS 1681
Cdd:pfam06008  238 LKTARDSLDAANLLLQ 253
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 829-877 7.83e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 64.30  E-value: 7.83e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396  829 CDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFSLDASNPKGC 877
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 690-738 1.61e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.53  E-value: 1.61e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396  690 CHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFPNCRPCDC 738
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 689-731 2.52e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.06  E-value: 2.52e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1002604396  689 PCHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFP 731
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1271-1317 4.17e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 4.17e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1002604396 1271 ECNCLSCGTDSCDPKTGQCRCKPGVTGQHCDRCQEGYYGYETCLGCQ 1317
Cdd:pfam00053    2 DCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 780-831 4.79e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 4.79e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1002604396  780 CNCSNSGIQDHTepgCNIESGQCQCKPNIVGRQCDLCAPGYYGYPNCRACDC 831
Cdd:pfam00053    1 CDCNPHGSLSDT---CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1272-1310 7.84e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.48  E-value: 7.84e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1002604396  1272 CNCLSCGT--DSCDPKTGQCRCKPGVTGQHCDRCQEGYYGY 1310
Cdd:smart00180    1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGD 41
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1272-1317 8.99e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 8.99e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1272 CNCLSCGT--DSCDPKTGQCRCKPGVTGQHCDRCQEGYYGY-ETCLGCQ 1317
Cdd:cd00055      2 CDCNGHGSlsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 828-878 1.23e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.13  E-value: 1.23e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1002604396  828 ACDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFSlDASNPKGCT 878
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1319-1366 1.43e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.75  E-value: 1.43e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1319 CDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDGCSKC 1366
Cdd:pfam00053    1 CDCNpHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1319-1363 2.64e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 2.64e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1002604396  1319 CDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDGC 1363
Cdd:smart00180    1 CDCDpGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
690-731 3.08e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 3.08e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1002604396   690 CHCHEAGAVSSQCEPFGGQCTCKSNIIGRECSRCATGYWGFP 731
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
829-877 1.09e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 1.09e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1002604396   829 CDCHEAGTKPSICDPVTGECHCKENVEGPRCDQCHLGTFsldASNPKGC 877
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
780-824 1.17e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 1.17e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1002604396   780 CNCSNSGiqdHTEPGCNIESGQCQCKPNIVGRQCDLCAPGYYGYP 824
Cdd:smart00180    1 CDCDPGG---SASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 780-824 1.46e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 1.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1002604396  780 CNCSNSGIQDHTepgCNIESGQCQCKPNIVGRQCDLCAPGYYGYP 824
Cdd:cd00055      2 CDCNGHGSLSGQ---CDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1318-1362 2.31e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 2.31e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1002604396 1318 RCDCD-IGSVSPNCHAQNGQCDCGPGVSGSRCQQCSPGYWGLSSDG 1362
Cdd:cd00055      1 PCDCNgHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1111-1152 6.66e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 6.66e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1002604396 1111 PCDCNGH---SDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNSS 1152
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPS 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1112-1156 3.05e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.20  E-value: 3.05e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1002604396 1112 CDCNGH---SDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNSSLEGN 1156
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQ 47
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1456-1662 1.93e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 56.34  E-value: 1.93e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1456 NGSMQTITSQVRDYQRFIYKVRQNADELEEENADFVQDLNALQH-KATMTHRKA------NSLMDVTQETFQLAESLVRN 1528
Cdd:pfam01576  355 TQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQaKQDSEHKRKklegqlQELQARLSESERQRAELAEK 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1529 VTKIQNNINDLIHLMNTFTTANTSSTS----------------AEEFRQKIAeVDAMLRHMKAMDFSFQSAIavEERDEL 1592
Cdd:pfam01576  435 LSKLQSELESVSSLLNEAEGKNIKLSKdvsslesqlqdtqellQEETRQKLN-LSTRLRQLEDERNSLQEQL--EEEEEA 511

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1593 KsKEMEKQYGTIQATLrmaKDSLGKISEHLQTIIKAKEESEKLLAQLDGARYPLSEKVKEYtlasNKIQK 1662
Cdd:pfam01576  512 K-RNVERQLSTLQAQL---SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAY----DKLEK 573
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1217-1270 3.49e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 3.49e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1002604396 1217 PCDCSGNADPNmlfSDCNTLTGVCTgCMYNTAGARCEICAAGFYGDAVVAKNCT 1270
Cdd:cd00055      1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1162-1215 8.31e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 47.35  E-value: 8.31e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002604396 1162 CPCPLSVPSN---NFATGciykgsttQCLCKPGYAGFSCERCAPGYYGNPLVIGSSC 1215
Cdd:pfam00053    1 CDCNPHGSLSdtcDPETG--------QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 34-86 1.12e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002604396   34 SCQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFNLESgNYFGCK 86
Cdd:cd00055      1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1112-1151 1.66e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.15  E-value: 1.66e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1002604396  1112 CDCNG---HSDQCLPGSGICLnCQHNTEGDHCERCKDGFVGNS 1151
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 35-85 2.24e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.24e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1002604396   35 CQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFNLESGNYFGC 85
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1422-1681 3.76e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 3.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1422 LEDLQKIDSDFPALEHQLKSLNttsiawarlhsinGSMQTITSQVRDYQRFIYKVRQNADELEEEnadfVQDLNALQHKA 1501
Cdd:PRK03918   230 VKELEELKEEIEELEKELESLE-------------GSKRKLEEKIRELEERIEELKKEIEELEEK----VKELKELKEKA 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1502 TmTHRKANSLMDVTQETFQLAESLVRNVTKIQNNINDLIhlmntfTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQ 1581
Cdd:PRK03918   293 E-EYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERI------KELEEKEERLEELKKKLKELEKRLEELEERHELYE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1582 SAIAVEER-DELKSKEMEKqygtiqatlrmakdSLGKISEHLQTIIKAKEESEKLLAQLDGARYPLSEKVKEYTLASNKI 1660
Cdd:PRK03918   366 EAKAKKEElERLKKRLTGL--------------TPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1002604396 1661 QKV---------ELAEQH-ANLLDELARNLS 1681
Cdd:PRK03918   432 KKAkgkcpvcgrELTEEHrKELLEEYTAELK 462
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1162-1208 4.74e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.99  E-value: 4.74e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1002604396  1162 CPCPlsvPSNNFATGCIYKgsTTQCLCKPGYAGFSCERCAPGYYGNP 1208
Cdd:smart00180    1 CDCD---PGGSASGTCDPD--TGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1185-1216 8.21e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.65  E-value: 8.21e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1002604396 1185 QCLCKPGYAGFSCERCAPGYYGNPLvIGSSCQ 1216
Cdd:cd00055     20 QCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1218-1263 1.27e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.88  E-value: 1.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1002604396 1218 CDCSGNADPNmlfSDCNTLTGVCTgCMYNTAGARCEICAAGFYGDA 1263
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
35-76 1.45e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.84  E-value: 1.45e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1002604396    35 CQCNTIGTMAGvaECQQGDGHCFCKPNICGQKCSICREGYFN 76
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 88-126 1.01e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.57  E-value: 1.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002604396   88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:cd00055      2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1-32 1.37e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1002604396    1 GSCECRAFVEGEACDKCKPLYWNLTPDNPFGC 32
Cdd:pfam00053   18 GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1473-1668 1.77e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1473 IYKVRQNADELEEENADFVQDLNALQHKATMTHRKANSLMDVTQETFQLAESLVRNVTKIQNNINDLIHLM--------- 1543
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELgeraralyr 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1544 ----NTFTTANTSSTSAEEFRQKIAEVDAMLRHMKAMDFSFQSAiaveeRDELKSKEMEkqygtIQATLRMAKDSLGKIS 1619
Cdd:COG3883     98 sggsVSYLDVLLGSESFSDFLDRLSALSKIADADADLLEELKAD-----KAELEAKKAE-----LEAKLAELEALKAELE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1002604396 1620 EHLQTIIKAKEESEKLLAQLDGARYPLSEKVKEYTLASNKIQKVELAEQ 1668
Cdd:COG3883    168 AAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1475-1678 2.07e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 45.29  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1475 KVRQNADELEEENADFVQDLNALQHKATMTHRKANSLMDVTQETFQLAESLV---RNVTKIQNNINDLIhlmNTFTTANT 1551
Cdd:COG1340     54 ELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELRKELAELNkagGSIDKLRKEIERLE---WRQQTEVL 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1552 SSTSAEEFRQKIAEVDAMLRHMKAmdfsfqsaiAVEERDELKskEMEKQYGTIQATLRMAKDSLG----KISEHLQTIIK 1627
Cdd:COG1340    131 SPEEEKELVEKIKELEKELEKAKK---------ALEKNEKLK--ELRAELKELRKEAEEIHKKIKelaeEAQELHEEMIE 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002604396 1628 AKEESEKLLAQLDgaryPLSEKVKEYTLASNKI--QKVELAEQHANLLDELAR 1678
Cdd:COG1340    200 LYKEADELRKEAD----ELHKEIVEAQEKADELheEIIELQKELRELRKELKK 248
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
88-126 2.36e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.37  E-value: 2.36e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1002604396    88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 88-126 6.06e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.26  E-value: 6.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1002604396   88 CQCDIGGSVGPLCEETTGSCQCRRNIRGPACSDPAKGFY 126
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1418-1595 1.12e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1418 VLLLLEDLQKIDSDFPALEHQLKSL--------NTTSIAWARLHSINGSMQTITSQVRDYQRFIYKVRQNADELEE--EN 1487
Cdd:COG1579      5 DLRALLDLQELDSELDRLEHRLKELpaelaeleDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlGN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1488 ADFVQDLNALQHKATMTHRKANSLMDVTQETFQLAESLVRNVTKIQNNINDLihlmntfttantsstsAEEFRQKIAEVD 1567
Cdd:COG1579     85 VRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAEL----------------EAELEEKKAELD 148

                          170       180
                   ....*....|....*....|....*...
gi 1002604396 1568 AMLRHMKAmdfsfQSAIAVEERDELKSK 1595
Cdd:COG1579    149 EELAELEA-----ELEELEAEREELAAK 171
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1217-1262 2.19e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.68  E-value: 2.19e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1002604396  1217 PCDCSGNADPnmlfsDCNTLTGVCTgCMYNTAGARCEICAAGFYGD 1262
Cdd:smart00180    2 DCDPGGSASG-----TCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
 1430-1625 2.43e-03

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 41.24  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1430 SDFPALEHQLKSLNTTSIAWarLHSINGSMQTITSQVRDY----QRFIYKVRQNADELEEEN----ADFVQDLNALQHKA 1501
Cdd:cd21116     30 DLLPSLNTHQALARAHALEW--LNEIKPKLLSLPNDIIGYnntfQSYYPDLIELADNLIKGDqgakQQLLQGLEALQSQV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002604396 1502 TMTHRKANSLMDVTQETFQLAESLVRNVTKIQNNIND-------LIHLMNTFTTANTSSTSAeefrqkiaeVDAMLRHMK 1574
Cdd:cd21116    108 TKKQTSVTSFINELTTFKNDLDDDSRNLQTDATKAQAqvavlnaLKNQLNSLAEQIDAAIDA---------LEKLSNDWQ 178

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1002604396 1575 AMDFSFQSAIaveerDELKSKEMEKQYGTIQATLRMAKDSLGKISEHLQTI 1625
Cdd:cd21116    179 TLDSDIKELI-----TDLEDAESSIDAAFLQADLKAAKADWNQLYEQAKSL 224
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1-33 7.96e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 7.96e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1002604396    1 GSCECRAFVEGEACDKCKPLYWNLtPDNPFGCT 33
Cdd:cd00055     19 GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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