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Conserved domains on  [gi|1002257796|ref|XP_015633214|]
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uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
90-436 2.57e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  90 TLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDDvsSKSFKILRinlPAGAHPTAIAFSQGASSVVvaaqallgssl 169
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLT---GHSGAVTSVAFSPDGKLLA----------- 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 170 ymyadvgappAGGNKQQGKL-SPPEIKWEHRKIHGKESVLNLAAARatygtgDGsTILISCSEATDIKIWHGKSGKELGT 248
Cdd:COG2319   179 ----------SGSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSP------DG-KLLASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 249 VDTNQLKNNMADISPNGRFIAAAAFTADVKVWeivyskDSSVKEVNKVmqLKGHKSAVTCLCFALNSEQIITASKDGTIR 328
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLW------DLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 329 VWNInvryhldEDPKTLRVLpiplhdsKGSVCQYDHMSVSPDEKVLATTSG-STLQWLCVETGAVLDTAeKAHEGDITGI 407
Cdd:COG2319   314 LWDL-------ATGKLLRTL-------TGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSV 378

                         330       340
                  ....*....|....*....|....*....
gi 1002257796 408 AWAprtiPNGGTpafvLATAGVDKKVKLW 436
Cdd:COG2319   379 AFS----PDGRT----LASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
90-436 2.57e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  90 TLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDDvsSKSFKILRinlPAGAHPTAIAFSQGASSVVvaaqallgssl 169
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLT---GHSGAVTSVAFSPDGKLLA----------- 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 170 ymyadvgappAGGNKQQGKL-SPPEIKWEHRKIHGKESVLNLAAARatygtgDGsTILISCSEATDIKIWHGKSGKELGT 248
Cdd:COG2319   179 ----------SGSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSP------DG-KLLASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 249 VDTNQLKNNMADISPNGRFIAAAAFTADVKVWeivyskDSSVKEVNKVmqLKGHKSAVTCLCFALNSEQIITASKDGTIR 328
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLW------DLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 329 VWNInvryhldEDPKTLRVLpiplhdsKGSVCQYDHMSVSPDEKVLATTSG-STLQWLCVETGAVLDTAeKAHEGDITGI 407
Cdd:COG2319   314 LWDL-------ATGKLLRTL-------TGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSV 378

                         330       340
                  ....*....|....*....|....*....
gi 1002257796 408 AWAprtiPNGGTpafvLATAGVDKKVKLW 436
Cdd:COG2319   379 AFS----PDGRT----LASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-436 8.68e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  88 VNTLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDDvssksfkilrinlpagahPTAIAFSQGASSVVVAAQALlGS 167
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET------------------GELLRTLKGHTGPVRDVAAS-AD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 168 SLYMYAdvgappaGGNKQQGKLSPPEIKWEHRKIHG-KESVLNLAAARAtygtgdgSTILISCSEATDIKIWHGKSGKEL 246
Cdd:cd00200    63 GTYLAS-------GSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETGKCL 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 247 GTVDTNQLKNNMADISPNGRFIAAAAFTADVKVWEIVYSKdssvkevnKVMQLKGHKSAVTCLCFALNSEQIITASKDGT 326
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--------CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 327 IRVWNINvryhldeDPKTLRVLPIplHDskGSVCqydHMSVSPDEKVLAttSGSTLQWLCV---ETGAVLDTAeKAHEGD 403
Cdd:cd00200   201 IKLWDLS-------TGKCLGTLRG--HE--NGVN---SVAFSPDGYLLA--SGSEDGTIRVwdlRTGECVQTL-SGHTNS 263

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1002257796 404 ITGIAWAPRTIpnggtpafVLATAGVDKKVKLW 436
Cdd:cd00200   264 VTSLAWSPDGK--------RLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 294-331 6.89e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 6.89e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1002257796  294 NKVMQLKGHKSAVTCLCFALNSEQIITASKDGTIRVWN 331
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
294-331 3.48e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 3.48e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1002257796 294 NKVMQLKGHKSAVTCLCFALNSEQIITASKDGTIRVWN 331
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
90-436 2.57e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  90 TLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDDvsSKSFKILRinlPAGAHPTAIAFSQGASSVVvaaqallgssl 169
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLT---GHSGAVTSVAFSPDGKLLA----------- 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 170 ymyadvgappAGGNKQQGKL-SPPEIKWEHRKIHGKESVLNLAAARatygtgDGsTILISCSEATDIKIWHGKSGKELGT 248
Cdd:COG2319   179 ----------SGSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSP------DG-KLLASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 249 VDTNQLKNNMADISPNGRFIAAAAFTADVKVWeivyskDSSVKEVNKVmqLKGHKSAVTCLCFALNSEQIITASKDGTIR 328
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLW------DLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 329 VWNInvryhldEDPKTLRVLpiplhdsKGSVCQYDHMSVSPDEKVLATTSG-STLQWLCVETGAVLDTAeKAHEGDITGI 407
Cdd:COG2319   314 LWDL-------ATGKLLRTL-------TGHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSV 378

                         330       340
                  ....*....|....*....|....*....
gi 1002257796 408 AWAprtiPNGGTpafvLATAGVDKKVKLW 436
Cdd:COG2319   379 AFS----PDGRT----LASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
20-436 1.20e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 1.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  20 AAIALLFLSGYLRRKRAAIAHLPPSATAAAPDQPKQVRPSNQNQPKKGHQRSHHAVDKDAAKKHHHLDVNTLRGHTDSVT 99
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 100 ALHFSDDACNLATVCADGAVRVFRVDDVssksfKILRINLPAGAHPTAIAFSQGASSVVVAAQallGSSLYMYadvgapp 179
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATG-----LLLRTLTGHTGAVRSVAFSPDGKTLASGSA---DGTVRLW------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 180 aggNKQQGKLsppeikwEHRKIHGKESVLNLAAaratygTGDGSTiLISCSEATDIKIWHGKSGKELGTVDTNQLKNNMA 259
Cdd:COG2319   148 ---DLATGKL-------LRTLTGHSGAVTSVAF------SPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 260 DISPNGRFIAAAAFTADVKVWeivyskdsSVKEVNKVMQLKGHKSAVTCLCFALNSEQIITASKDGTIRVWNInvryhld 339
Cdd:COG2319   211 AFSPDGKLLASGSADGTVRLW--------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------- 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 340 EDPKTLRVLPIPlhdsKGSVCQydhMSVSPDEKVLATTSG-STLQWLCVETGAVLDTAeKAHEGDITGIAWAprtiPNGG 418
Cdd:COG2319   276 ATGELLRTLTGH----SGGVNS---VAFSPDGKLLASGSDdGTVRLWDLATGKLLRTL-TGHTGAVRSVAFS----PDGK 343

                         410
                  ....*....|....*...
gi 1002257796 419 TpafvLATAGVDKKVKLW 436
Cdd:COG2319   344 T----LASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-436 8.68e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  88 VNTLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDDvssksfkilrinlpagahPTAIAFSQGASSVVVAAQALlGS 167
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET------------------GELLRTLKGHTGPVRDVAAS-AD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 168 SLYMYAdvgappaGGNKQQGKLSPPEIKWEHRKIHG-KESVLNLAAARAtygtgdgSTILISCSEATDIKIWHGKSGKEL 246
Cdd:cd00200    63 GTYLAS-------GSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETGKCL 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 247 GTVDTNQLKNNMADISPNGRFIAAAAFTADVKVWEIVYSKdssvkevnKVMQLKGHKSAVTCLCFALNSEQIITASKDGT 326
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--------CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 327 IRVWNINvryhldeDPKTLRVLPIplHDskGSVCqydHMSVSPDEKVLAttSGSTLQWLCV---ETGAVLDTAeKAHEGD 403
Cdd:cd00200   201 IKLWDLS-------TGKCLGTLRG--HE--NGVN---SVAFSPDGYLLA--SGSEDGTIRVwdlRTGECVQTL-SGHTNS 263

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1002257796 404 ITGIAWAPRTIpnggtpafVLATAGVDKKVKLW 436
Cdd:cd00200   264 VTSLAWSPDGK--------RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
88-333 6.94e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 6.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  88 VNTLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDDVssksfKILRINLPAGAHPTAIAFSQGASSVVVAAQallGS 167
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-----KLLRTLTGHSGSVRSVAFSPDGRLLASGSA---DG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 168 SLYMYadvgappaggNKQQGKLSppeikweHRKIHGKESVLNLAAaratygTGDGSTiLISCSEATDIKIWHGKSGKELG 247
Cdd:COG2319   269 TVRLW----------DLATGELL-------RTLTGHSGGVNSVAF------SPDGKL-LASGSDDGTVRLWDLATGKLLR 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 248 TVDTNQLKNNMADISPNGRFIAAAAFTADVKVWEIvyskdSSVKEVNKvmqLKGHKSAVTCLCFALNSEQIITASKDGTI 327
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-----ATGELLRT---LTGHTGAVTSVAFSPDGRTLASGSADGTV 396


                  ....*.
gi 1002257796 328 RVWNIN 333
Cdd:COG2319   397 RLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
176-436 3.01e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 3.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 176 GAPPAGGNKQQGKLSPPEIKWEHRKIHGKESVLNLAAARATYGTGDGSTILISCSEATDIKIWHGKSGKELGTVDTNQLK 255
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 256 NNMADISPNGRFIAAAAFTADVKVWEIVYSKDssvkevnkVMQLKGHKSAVTCLCFALNSEQIITASKDGTIRVWNInvr 335
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLL--------LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 336 yhldEDPKTLRVLPIPlhdsKGSVcqyDHMSVSPDEKVLATTSG-STLQWLCVETGAVLDTAeKAHEGDITGIAWAprti 414
Cdd:COG2319   150 ----ATGKLLRTLTGH----SGAV---TSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTL-TGHTGAVRSVAFS---- 213

                         250       260
                  ....*....|....*....|..
gi 1002257796 415 PNGGTpafvLATAGVDKKVKLW 436
Cdd:COG2319   214 PDGKL----LASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-331 1.66e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796  88 VNTLRGHTDSVTALHFSDDaCNLATVC-ADGAVRVFrvdDVSSKSFKILrinlpAGAHP---TAIAFSQGASSVVVAAQa 163
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPD-GRILSSSsRDKTIKVW---DVETGKCLTT-----LRGHTdwvNSVAFSPDGTFVASSSQ- 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 164 llGSSLYMYadvgappaggNKQQGKLSppeikwehRKIHG-KESVLNLAAaratygTGDGSTiLISCSEATDIKIWHGKS 242
Cdd:cd00200   156 --DGTIKLW----------DLRTGKCV--------ATLTGhTGEVNSVAF------SPDGEK-LLSSSSDGTIKLWDLST 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 243 GKELGTVDTNQLKNNMADISPNGRFIAAAAFTADVKVWeivyskdsSVKEVNKVMQLKGHKSAVTCLCFALNSEQIITAS 322
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW--------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                  ....*....
gi 1002257796 323 KDGTIRVWN 331
Cdd:cd00200   281 ADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 294-331 6.89e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 6.89e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1002257796  294 NKVMQLKGHKSAVTCLCFALNSEQIITASKDGTIRVWN 331
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
294-331 3.48e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 3.48e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1002257796 294 NKVMQLKGHKSAVTCLCFALNSEQIITASKDGTIRVWN 331
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 88-122 5.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1002257796   88 VNTLRGHTDSVTALHFSDDACNLATVCADGAVRVF 122
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
88-122 6.02e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1002257796  88 VNTLRGHTDSVTALHFSDDACNLATVCADGAVRVF 122
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
88-126 6.63e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 6.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1002257796  88 VNTLRGHTDSVTALHFSDDACNLATVCADGAVRVFRVDD 126
Cdd:COG2319   365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 261-326 5.05e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002257796 261 ISPNGRFIAAAAFTADVKVWEIVYSKDSSVKEVNKVMQ---------------LKGHKSAVTCLCFALNSEQIITASKDG 325
Cdd:pfam20426 132 VTSDGSILATGSYDTTVMVWEVLRGRSSEKRSRNTQTEfprkdhviaetpfhiLCGHDDIITCLYVSVELDIVISGSKDG 211


                  .
gi 1002257796 326 T 326
Cdd:pfam20426 212 T 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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