|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
96-764 |
3.15e-165 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 507.03 E-value: 3.15e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 96 EEGQLLEPVKEEKADDFVDAVPSLPIDLEAKNGDASLITDAMKE----EEEKLHD-ARVKAEEEEVARKREEAARLAFDP 170
Cdd:PLN03142 13 EDEEELEAVARSAGSDSDDDEVPAEDEDEDEEDDEEAESPAKAEiskrEKARLKElKKQKKQEIQKILEQQNAAIDADMN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 171 NARFNKLDELLSQTQLYSEFLlekmetiadvEGVQTHAEEepveeKKNGRGRKrkatsapkyndkkakkavAVMLTRSHE 250
Cdd:PLN03142 93 NKGKGRLKYLLQQTEIFAHFA----------KGDQSASAK-----KAKGRGRH------------------ASKLTEEEE 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 251 DcspEDCTLTEEERWEKEQA-RLV--PLMTGGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGK 326
Cdd:PLN03142 140 D---EEYLKEEEDGLGGSGGtRLLvqPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLhEYR 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 327 GLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLIYHGDKAARAEIRRKFMPKTtgpDFPLIVTSYEMAMSDAKHLAHYKWK 406
Cdd:PLN03142 217 GITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAG---KFDVCVTSFEMAIKEKTALKRFSWR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 407 YVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGeeeqeds 486
Cdd:PLN03142 294 YIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGEND------- 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 487 eekrKVDVVSKLHAILRPFLLRRMKEDVEHMLPRKKEIIIYANMTDHQKQIQNHLVEQTFDqylhekseiVLRKPGIKAK 566
Cdd:PLN03142 367 ----QQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLD---------VVNAGGERKR 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 567 LNNLLIQLRKNCNHPDLLESAYDSsglyPPV---EKLLEQCGKFQLLNRLLSLLLARKHKVLIFSQWTKVLDIIEYYLET 643
Cdd:PLN03142 434 LLNIAMQLRKCCNHPYLFQGAEPG----PPYttgEHLVENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMY 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 644 KGLQVCRIDGSVKLEERRRQIAEFNDLNSSMNIFILSTRAGGLGINLTSADTCILYDSDWNPQMDLQAMDRCHRIGQTRP 723
Cdd:PLN03142 510 RGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKE 589
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 1002296320 724 VHVYRLATSHSVEGRIIKKAFGKLRLEHVVIGKGQFEQDRA 764
Cdd:PLN03142 590 VQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLAEQKT 630
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
54-755 |
8.98e-145 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 443.13 E-value: 8.98e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 54 EEDHLDVLIEEKVDGFVDASSSLNVEPAANNSDLSPLTVPVKEEGQLLEPVKEEKADDFVDAVPSLPIDLEAKNGDASLI 133
Cdd:COG0553 12 ALGLLLTELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 134 TDAMKEEEEKLHDARVKAEEEEVARKREEAARLAFDPNARFNKLDELLSQTQLYSEFLLEKMETIADVEGVQTHAEEEPV 213
Cdd:COG0553 92 LLLALLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 214 EEKKNGRGRKRKATSAPKYNDKKAKKAVAVMLTRSHEDCSPEDCTLTEEE---RWEKEQARLVPLMTGGKLKSYQIKGVK 290
Cdd:COG0553 172 LEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAfrlRRLREALESLPAGLKATLRPYQLEGAA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 291 WLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLIYHGDKaARAEI 370
Cdd:COG0553 252 WLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR-ERAKG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 371 RRKFmpkttgPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAEL 450
Cdd:COG0553 331 ANPF------EDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEEL 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 451 WSLLNFILPDIFSSHQEFESWFdfsakggeeeqEDSEEKRKVDVVSKLHAILRPFLLRRMKEDVEHMLPRKKEIIIYANM 530
Cdd:COG0553 405 WSLLDFLNPGLLGSLKAFRERF-----------ARPIEKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVEL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 531 TDHQKQIqnhlveqtFDQYLHEKSEIVLRKPGIKAKLNNL--LIQLRKNCNHPDLLESAYDSSGLYPP-VEKLLEQCGKF 607
Cdd:COG0553 474 TPEQRAL--------YEAVLEYLRRELEGAEGIRRRGLILaaLTRLRQICSHPALLLEEGAELSGRSAkLEALLELLEEL 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 608 qllnrllsllLARKHKVLIFSQWTKVLDIIEYYLETKGLQVCRIDGSVKLEERRRQIAEFNDlNSSMNIFILSTRAGGLG 687
Cdd:COG0553 546 ----------LAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQE-GPEAPVFLISLKAGGEG 614
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 688 INLTSADTCILYDSDWNPQMDLQAMDRCHRIGQTRPVHVYRLATSHSVEGRIIKKAFGKLRLEHVVIG 755
Cdd:COG0553 615 LNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
278-511 |
5.98e-137 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 406.00 E-value: 5.98e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 278 GGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTG 357
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 358 LIYHGDKAARAEIRRKFMP-KTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKL 436
Cdd:cd18009 81 LLYHGTKEERERLRKKIMKrEGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296320 437 LLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKG-GEEEQEDSEEKRKVDVVSKLHAILRPFLLRRMK 511
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSdNAADISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
284-584 |
3.51e-97 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 304.99 E-value: 3.51e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 284 YQIKGVKWLISLWQN-GLNGILADQMGLGKTIQTIGFLAHLKG--KGLDGPYLIIAPLSTLSNWVNEISRFV--PSMTGL 358
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHvdKNWGGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 359 IYHGDKAARAEIRRKFMpktTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLL 438
Cdd:pfam00176 81 VLHGNKRPQERWKNDPN---FLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 439 TGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEqedseekrkvDVVSKLHAILRPFLLRRMKEDVEHML 518
Cdd:pfam00176 158 TGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGK----------KGVSRLHKLLKPFLLRRTKKDVEKSL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002296320 519 PRKKEIIIYANMTDHQKQI-QNHLVEQTFDQYLHEKSEivlrkPGIKAKLNNLLIQLRKNCNHPDLL 584
Cdd:pfam00176 228 PPKVEYILFCRLSKLQRKLyQTFLLKKDLNAIKTGEGG-----REIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
278-511 |
8.62e-95 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 296.16 E-value: 8.62e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 278 GGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKG-KGLDGPYLIIAPLSTLSNWVNEISRFVPSMT 356
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 357 GLIYHGDKAARAEI-RRKFMPKttgpDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNK 435
Cdd:cd17997 81 VVVLIGDKEERADIiRDVLLPG----KFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNR 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296320 436 LLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDfsakggeeeqEDSEEKRKVDVVSKLHAILRPFLLRRMK 511
Cdd:cd17997 157 LLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN----------VNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
278-511 |
4.39e-90 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 284.26 E-value: 4.39e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 278 GGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMT 356
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLmEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 357 GLIYHGDKAARAEIRRKFMPKttgpDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKR-LPMDNK 435
Cdd:cd17996 81 KIVYKGTPDVRKKLQSQIRAG----KFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYR 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 436 LLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFD--FsAKGGEEEQEDSEEKRKVDVVSKLHAILRPFLLRRMK 511
Cdd:cd17996 157 LLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNtpF-ANTGEQVKIELNEEETLLIIRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
281-462 |
6.44e-81 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 257.88 E-value: 6.44e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLK-GKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLkEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIRRKFMPkttgPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLT 439
Cdd:cd17919 81 YHGSQRERAQIRAKEKL----DKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLT 156
|
170 180
....*....|....*....|...
gi 1002296320 440 GTPLQNNLAELWSLLNFILPDIF 462
Cdd:cd17919 157 GTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
281-509 |
6.62e-78 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 251.40 E-value: 6.62e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGK-GLDGPYLIIAPLSTLSNWVNEISRFVPsMTGLI 359
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVeGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIR---RKFMPKTTGPD-----FPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLP 431
Cdd:cd17995 80 YHGSGESRQIIQqyeMYFKDAQGRKKkgvykFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 432 MDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFdfsakGGEeeqedseekRKVDVVSKLHAILRPFLLRR 509
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF-----GDL---------KTAEQVEKLQALLKPYMLRR 223
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
281-509 |
2.86e-74 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 242.03 E-value: 2.86e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLaEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIRRKFMPKT-TGPD--FPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKL 436
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNlYTRDapFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296320 437 LLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFdfsaKGGEEEQEDSEEKRKVDVVSKLHAILRPFLLRR 509
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWF----SKDIESHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
281-509 |
1.22e-72 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 237.25 E-value: 1.22e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLK-GKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLAcEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIRRKFMPKTTgpdFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLT 439
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNS---FHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLT 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 440 GTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEQEDSEEKrkvdVVSKLHAILRPFLLRR 509
Cdd:cd18003 158 GTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEE----LVRRLHKVLRPFLLRR 223
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
279-522 |
3.91e-71 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 234.17 E-value: 3.91e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 279 GKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKG-KGLDGPYLIIAPLSTLSNWVNEISRFVPSMTG 357
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHyRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 358 LIYHGDKAARAE-IRRKFMPKttgpDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKL 436
Cdd:cd18064 94 VCLIGDKDQRAAfVRDVLLPG----EWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 437 LLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEqedseekrkvdVVSKLHAILRPFLLRRMKEDVEH 516
Cdd:cd18064 170 LLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLGDQK-----------LVERLHMVLRPFLLRRIKADVEK 238
|
....*.
gi 1002296320 517 MLPRKK 522
Cdd:cd18064 239 SLPPKK 244
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
263-511 |
5.28e-71 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 234.17 E-value: 5.28e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 263 ERWEKEQArlvpLMTGGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTL 341
Cdd:cd18062 10 EKVEKQSS----LLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLmEHKRINGPFLIIVPLSTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 342 SNWVNEISRFVPSMTGLIYHGDKAAraeiRRKFMPKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKC 421
Cdd:cd18062 86 SNWVYEFDKWAPSVVKVSYKGSPAA----RRAFVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 422 LLLRELK-RLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFD--FSAKGgeeEQEDSEEKRKVDVVSKL 498
Cdd:cd18062 162 KLTQVLNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNapFAMTG---EKVDLNEEETILIIRRL 238
|
250
....*....|...
gi 1002296320 499 HAILRPFLLRRMK 511
Cdd:cd18062 239 HKVLRPFLLRRLK 251
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
280-509 |
7.63e-71 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 232.25 E-value: 7.63e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 280 KLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGL 358
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLfHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 359 IYHGDKAARAEIRR-KFMPKTTGP-DFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKL 436
Cdd:cd17993 81 VYLGDIKSRDTIREyEFYFSQTKKlKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296320 437 LLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGeeeqedseekrkvdvVSKLHAILRPFLLRR 509
Cdd:cd17993 161 LITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEEQEKG---------------IADLHKELEPFILRR 218
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
276-511 |
1.16e-69 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 229.90 E-value: 1.16e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 276 MTGGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKG-KGLDGPYLIIAPLSTLSNWVNEISRFVPS 354
Cdd:cd18065 11 VKGGTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHyRNIPGPHMVLVPKSTLHNWMNEFKRWVPS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 355 MTGLIYHGDKAARAE-IRRKFMPKttgpDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMD 433
Cdd:cd18065 91 LRAVCLIGDKDARAAfIRDVMMPG----EWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTT 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 434 NKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEqedseekrkvdVVSKLHAILRPFLLRRMK 511
Cdd:cd18065 167 NRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQK-----------LVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
263-511 |
7.18e-69 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 228.41 E-value: 7.18e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 263 ERWEKEQArlvpLMTGGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTL 341
Cdd:cd18063 10 ERVEKQSS----LLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLmEHKRLNGPYLIIVPLSTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 342 SNWVNEISRFVPSMTGLIYHGDKAaraeIRRKFMPKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKC 421
Cdd:cd18063 86 SNWTYEFDKWAPSVVKISYKGTPA----MRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 422 LLLRELK-RLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFD--FSAKGgeeEQEDSEEKRKVDVVSKL 498
Cdd:cd18063 162 KLTQVLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNapFAMTG---ERVDLNEEETILIIRRL 238
|
250
....*....|...
gi 1002296320 499 HAILRPFLLRRMK 511
Cdd:cd18063 239 HKVLRPFLLRRLK 251
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
279-511 |
4.43e-68 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 224.75 E-value: 4.43e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 279 GKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGL 358
Cdd:cd18012 3 ATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 359 IYHGDKAARAEIRRKfmpkttgPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLL 438
Cdd:cd18012 83 VIHGTKRKREKLRAL-------EDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLAL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296320 439 TGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKggeeeqedseEKRKVDVVSKLHAILRPFLLRRMK 511
Cdd:cd18012 156 TGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIE----------KDGDEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
281-462 |
1.85e-67 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 222.26 E-value: 1.85e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLIY 360
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 HGDKAARAEIRRKFMPKTTgpDFPLIVTSYEMAMS---DAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLL 437
Cdd:cd17998 81 YGSQEERKHLRYDILKGLE--DFDVIVTTYNLATSnpdDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLL 158
|
170 180
....*....|....*....|....*
gi 1002296320 438 LTGTPLQNNLAELWSLLNFILPDIF 462
Cdd:cd17998 159 LTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
281-509 |
8.96e-66 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 218.46 E-value: 8.96e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGK-GLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRlKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIRRKFMpktTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLT 439
Cdd:cd18006 81 YMGDKEKRLDLQQDIK---STNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLT 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 440 GTPLQNNLAELWSLLNFILPDIFSShqefESWFDFSAKggeeeqeDSEEKRKVDVVSKLHAILRPFLLRR 509
Cdd:cd18006 158 GTPIQNSLQELYALLSFIEPNVFPK----DKLDDFIKA-------YSETDDESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
274-509 |
1.39e-58 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 199.85 E-value: 1.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 274 PLMTGGK---LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTLSNWVNEIS 349
Cdd:cd18054 11 PSYIGGEnleLRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLfHQHQLYGPFLLVVPLSTLTSWQREFE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 350 RFVPSMTGLIYHGDKAARAEIRRK--FMPKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLREL 427
Cdd:cd18054 91 IWAPEINVVVYIGDLMSRNTIREYewIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 428 KRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDifsshqEFESWFDFSAKGGeeeqedseeKRKVDVVSKLHAILRPFLL 507
Cdd:cd18054 171 IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPE------KFEFWEDFEEDHG---------KGRENGYQSLHKVLEPFLL 235
|
..
gi 1002296320 508 RR 509
Cdd:cd18054 236 RR 237
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
604-729 |
6.52e-56 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 188.45 E-value: 6.52e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 604 CGKFQLLNRLLSLLLARKHKVLIFSQWTKVLDIIEYYLETKGLQVCRIDGSVKLEERRRQIAEFNDlNSSMNIFILSTRA 683
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNE-DPDIRVFLLSTKA 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1002296320 684 GGLGINLTSADTCILYDSDWNPQMDLQAMDRCHRIGQTRPVHVYRL 729
Cdd:cd18793 89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRL 134
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
281-509 |
6.84e-56 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 191.81 E-value: 6.84e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRFVpSMTGLIY 360
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 HGDKAARAEIRR----------KFMPKTTgpDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRL 430
Cdd:cd18060 80 HGSLASRQMIQQyemyckdsrgRLIPGAY--KFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 431 PMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWF-DFSAKggeeeqedseekrkvDVVSKLHAILRPFLLRR 509
Cdd:cd18060 158 DLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFgDLKTE---------------EQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
281-509 |
1.34e-55 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 191.02 E-value: 1.34e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEIsRFVPSMTGLIY 360
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREF-RTWTEMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 HGDKAARAEIRRKFM--------PKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPM 432
Cdd:cd18058 80 HGSQISRQMIQQYEMyyrdeqgnPLSGIFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMAL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 433 DNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEF-ESWFDFSAKggeeeqedseekrkvDVVSKLHAILRPFLLRR 509
Cdd:cd18058 160 EHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFlEEFGDLKTE---------------EQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
281-509 |
2.75e-53 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 183.79 E-value: 2.75e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKG-LDGPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGhSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKaaraeirrkfmpkttgpdfpLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLT 439
Cdd:cd17994 81 YVGDH--------------------VLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLT 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 440 GTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGgeeeqedseekrkvDVVSKLHAILRPFLLRR 509
Cdd:cd17994 141 GTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKE--------------DQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
281-509 |
8.59e-53 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 183.31 E-value: 8.59e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEIsRFVPSMTGLIY 360
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREF-RTWTELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 HGDKAARAEIR--RKFMPKTTGP------DFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPM 432
Cdd:cd18059 80 HGSQASRRTIQlyEMYFKDPQGRvikgsyKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 433 DNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWF-DFSAKggeeeqedseekrkvDVVSKLHAILRPFLLRR 509
Cdd:cd18059 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFgDLKTE---------------EQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
267-509 |
1.76e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 180.25 E-value: 1.76e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 267 KEQARLVPLMTGGKLKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHL-KGKGLDGPYLIIAPLSTLSNWV 345
Cdd:cd18053 7 KKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLfHEHQLYGPFLLVVPLSTLTSWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 346 NEISRFVPSMTGLIYHGDKAARAEIR-RKFM-PKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLL 423
Cdd:cd18053 87 REIQTWAPQMNAVVYLGDINSRNMIRtHEWMhPQTKRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 424 LRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPdifsshQEFESWFDFSAKGGeeeqedseeKRKVDVVSKLHAILR 503
Cdd:cd18053 167 YKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP------EKFSSWEDFEEEHG---------KGREYGYASLHKELE 231
|
....*.
gi 1002296320 504 PFLLRR 509
Cdd:cd18053 232 PFLLRR 237
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
281-509 |
5.29e-51 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 178.72 E-value: 5.29e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLIY 360
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 HGdkAARAEIRRKFMPKTTGpdFPLIVTSYEMAMSDAKHLAHY-----KWKYVIVDEGHRLKNSKCLLLRELKRLPMDNK 435
Cdd:cd18001 81 HG--TSKKERERNLERIQRG--GGVLLTTYGMVLSNTEQLSADdhdefKWDYVILDEGHKIKNSKTKSAKSLREIPAKNR 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296320 436 LLLTGTPLQNNLAELWSLLNFILP-DIFSSHQEFESWFDFSAKGGEEEQEDSEEKRKVDVVSK-LHAILRPFLLRR 509
Cdd:cd18001 157 IILTGTPIQNNLKELWALFDFACNgSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAEnLRQIIKPYFLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
284-459 |
1.16e-48 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 170.58 E-value: 1.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 284 YQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKG-KGLDGPYLIIAPLSTLSNWVNEISRFVPSMTGLIYH- 361
Cdd:cd18000 4 YQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHsKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVVLHs 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 362 -------GDKAARAEIRRKFMPKTTgPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDN 434
Cdd:cd18000 84 sgsgtgsEEKLGSIERKSQLIRKVV-GDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPH 162
|
170 180
....*....|....*....|....*
gi 1002296320 435 KLLLTGTPLQNNLAELWSLLNFILP 459
Cdd:cd18000 163 RLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
281-509 |
1.32e-47 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 169.04 E-value: 1.32e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKG-LDGPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGhTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIR---------------RKFMPKTTGP-DFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLL 423
Cdd:cd18055 81 YTGDKDSRAIIRenefsfddnavkggkKAFKMKREAQvKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 424 LRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEF-ESWFDFSakggeeeqedseekrKVDVVSKLHAIL 502
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFlEEFADIS---------------KEDQIKKLHDLL 225
|
....*..
gi 1002296320 503 RPFLLRR 509
Cdd:cd18055 226 GPHMLRR 232
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
281-509 |
7.00e-47 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 167.14 E-value: 7.00e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLA--HLKGKGLDG----PYLIIAPLSTLSNWVNEISRFVP- 353
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdHHKRANSFNsenlPSLVVCPPTLVGHWVAEIKKYFPn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 354 -SMTGLIYHGDKAARAEIRRKFmpkttgPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPM 432
Cdd:cd17999 81 aFLKPLAYVGPPQERRRLREQG------EKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 433 DNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWF----------DFSAKggeeeqedsEEKRKVDVVSKLHAIL 502
Cdd:cd17999 155 NHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFlkpilasrdsKASAK---------EQEAGALALEALHKQV 225
|
....*..
gi 1002296320 503 RPFLLRR 509
Cdd:cd17999 226 LPFLLRR 232
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
281-509 |
8.38e-47 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 166.33 E-value: 8.38e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEIsRFVPSMTGLIY 360
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREF-RTWTDLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 HGDKAARAEIRR--KFMPKTTGP------DFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPM 432
Cdd:cd18061 80 HGSLISRQMIQQyeMYFRDSQGRiirgayRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 433 DNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWF-DFSAKggeeeqedseekrkvDVVSKLHAILRPFLLRR 509
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFgDLKTE---------------EQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
281-509 |
1.05e-46 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 166.78 E-value: 1.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLD-GPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSkGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIRRK----------------FMPKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLL 423
Cdd:cd18057 81 YTGDKESRSVIRENefsfednairsgkkvfRMKKEAQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 424 LRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEF-ESWFDFSakggeeeqedseekrKVDVVSKLHAIL 502
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFlEEFADIS---------------KEDQIKKLHDLL 225
|
....*..
gi 1002296320 503 RPFLLRR 509
Cdd:cd18057 226 GPHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
281-509 |
9.38e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 161.00 E-value: 9.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLD-GPYLIIAPLSTLSNWVNEISRFVPSMTGLI 359
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSkGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YHGDKAARAEIRRK----------------FMPKTTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLL 423
Cdd:cd18056 81 YVGDKDSRAIIRENefsfednairggkkasRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 424 LRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEF-ESWFDFSakggeeeqedseekrKVDVVSKLHAIL 502
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFlEEFADIA---------------KEDQIKKLHDML 225
|
....*..
gi 1002296320 503 RPFLLRR 509
Cdd:cd18056 226 GPHMLRR 232
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
281-509 |
9.23e-44 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 158.60 E-value: 9.23e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISlwqNGlnGILADQMGLGKTIQTIGFLAHLKGKGLDGPY------------------LIIAPLSTLS 342
Cdd:cd18008 1 LLPYQKQGLAWMLP---RG--GILADEMGLGKTIQALALILATRPQDPKIPEeleenssdpkklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 343 NWVNEISRFV--PSMTGLIYHGDKaaraeiRRKFMPKTTGPDfpLIVTSY-EMAMSDAKH---------------LAHYK 404
Cdd:cd18008 76 QWKDEIEKHTkpGSLKVYVYHGSK------RIKSIEELSDYD--IVITTYgTLASEFPKNkkgggrdskekeaspLHRIR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 405 WKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEQe 484
Cdd:cd18008 148 WYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRKA- 226
|
250 260
....*....|....*....|....*
gi 1002296320 485 dseekrkvdvVSKLHAILRPFLLRR 509
Cdd:cd18008 227 ----------LERLQALLKPILLRR 241
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
281-509 |
3.86e-42 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 154.07 E-value: 3.86e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGKGLDG---------------------PYLIIAPLS 339
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGKTGTRrdrennrprfkkkppassakkPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 340 TLSNWVNEISRFvPSMTGLIYHGDK-----AARAEIRRkfmpkttgpdFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGH 414
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRkddelEGRLKAGR----------LEVVVTTYDTLRRCIDSLNSINWSAVIADEAH 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 415 RLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEQEDSEEKRKVD- 493
Cdd:cd18005 150 RIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRk 229
|
250
....*....|....*.
gi 1002296320 494 VVSKLHAILRPFLLRR 509
Cdd:cd18005 230 RKQELAVKLSKFFLRR 245
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
281-509 |
1.57e-38 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 143.58 E-value: 1.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLIS--LWQNGLNG---ILADQMGLGKTIQTIGFL-AHLKGKGLDGP----YLIIAPLSTLSNWVNEISR 350
Cdd:cd18004 1 LRPHQREGVQFLYDclTGRRGYGGggaILADEMGLGKTLQAIALVwTLLKQGPYGKPtakkALIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 351 FVPSMTGLIYHGDKAARAEIRRKfMPKTTGPDFPLIVTSYEMAMSDAKHLAHYK-WKYVIVDEGHRLKNSKCLLLRELKR 429
Cdd:cd18004 81 WLGLRRIKVVTADGNAKDVKASL-DFFSSASTYPVLIISYETLRRHAEKLSKKIsIDLLICDEGHRLKNSESKTTKALNS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 430 LPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGGEEEQEDSEEKRKVDVVSK-LHAILRPFLLR 508
Cdd:cd18004 160 LPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQeLSELTSRFILR 239
|
.
gi 1002296320 509 R 509
Cdd:cd18004 240 R 240
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
281-472 |
1.07e-35 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 135.50 E-value: 1.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLislWQNgLNG-----------ILADQMGLGKTIQTIGFL-AHLKGKGLDGPYLIIAPLSTLSNWVNEI 348
Cdd:cd18007 1 LKPHQVEGVRFL---WSN-LVGtdvgsdegggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 349 SRFVPSMTgLIYHGDKAARAEIRRKFMPKT-----TGPDFPLIvtSYEM-------AMSDAK-HLAHYKW------KYVI 409
Cdd:cd18007 77 KKWLPPDL-RPLLVLVSLSASKRADARLRKinkwhKEGGVLLI--GYELfrnlasnATTDPRlKQEFIAAlldpgpDLLV 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296320 410 VDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWF 472
Cdd:cd18007 154 LDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKF 216
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
281-468 |
1.46e-32 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 125.40 E-value: 1.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISlwQNGlNGILADQMGLGKTIQTIGFLAHLKGkglDGPYLIIAPLSTLSNWVNEISRFVPSMTgliy 360
Cdd:cd18010 1 LLPFQREGVCFALR--RGG-RVLIADEMGLGKTVQAIAIAAYYRE---EWPLLIVCPSSLRLTWADEIERWLPSLP---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 361 hgdkaaRAEIRRKFMPKTTGPDF-PLIV-TSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNK--L 436
Cdd:cd18010 71 ------PDDIQVIVKSKDGLRDGdAKVViVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKrvI 144
|
170 180 190
....*....|....*....|....*....|..
gi 1002296320 437 LLTGTPLQNNLAELWSLLNFILPDIFSSHQEF 468
Cdd:cd18010 145 LLSGTPALSRPIELFTQLDALDPKLFGRFHDF 176
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
273-465 |
1.22e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 119.52 E-value: 1.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 273 VPLMTGGKLKSYQIKGVKWLISLWQNGlngILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTL-SNWVNEISRF 351
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDV---ILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 352 VPSMTG---LIYHGDKaaraeiRRKFMPKTTGPDFPLIVTSYEMAMSDAKH--LAHYKWKYVIVDEGHRLKNS--KCLLL 424
Cdd:smart00487 78 GPSLGLkvvGLYGGDS------KREQLRKLESGKTDILVTTPGRLLDLLENdkLSLSNVDLVILDEAHRLLDGgfGDQLE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1002296320 425 RELKRLPMDNK-LLLTGTP---LQNNLAELWSLLNFILPDIFSSH 465
Cdd:smart00487 152 KLLKLLPKNVQlLLLSATPpeeIENLLELFLNDPVFIDVGFTPLE 196
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
281-509 |
7.85e-29 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 115.64 E-value: 7.85e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWL----ISLWQNGLNG-ILADQMGLGKTIQTIGFLAHLKGKGLDGPYLI-----IAPLSTLSNWVNEISR 350
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaivVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 351 FV-PSMTGLIYHGDKAARAEIRRKFMPKTTGPDF--PLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLREL 427
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKEIDRKLVQWASQQGRRVstPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 428 KRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSA-KGGEEEQEDSEEKRKVDVVSKLHAILRPFL 506
Cdd:cd18067 161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPIlKGRDADASEKERQLGEEKLQELISIVNRCI 240
|
...
gi 1002296320 507 LRR 509
Cdd:cd18067 241 IRR 243
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
619-719 |
7.76e-28 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 108.07 E-value: 7.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 619 ARKHKVLIFSQWTKVLDIiEYYLETKGLQVCRIDGSVKLEERRRQIAEFNDLNSsmnIFILSTRAGGLGINLTSADTCIL 698
Cdd:pfam00271 13 ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKI---DVLVATDVAERGLDLPDVDLVIN 88
|
90 100
....*....|....*....|.
gi 1002296320 699 YDSDWNPQMDLQAMDRCHRIG 719
Cdd:pfam00271 89 YDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
281-479 |
4.14e-26 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 107.21 E-value: 4.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLislWQN------------GLNGILADQMGLGKTIQTIGF----LAHLKGKGLdgpyLIIAPLSTLSNW 344
Cdd:cd18069 1 LKPHQIGGIRFL---YDNiieslerykgssGFGCILAHSMGLGKTLQVISFldvlLRHTGAKTV----LAIVPVNTLQNW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 345 VNEISRFVPSMTGLIYH----------GDKAARAEIRRKFMPKTTGpDFPLIVTSYEMamsdakhlahYKWK----YVIV 410
Cdd:cd18069 74 LSEFNKWLPPPEALPNVrprpfkvfilNDEHKTTAARAKVIEDWVK-DGGVLLMGYEM----------FRLRpgpdVVIC 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296320 411 DEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAKGG 479
Cdd:cd18069 143 DEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNG 211
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
297-470 |
8.76e-25 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 104.09 E-value: 8.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 297 QNGLNGILADQMGLGKTIQTIGFLahlkgkgLDGPYLIIAPLSTLSNWVNEISRFVPS--MTGLIYHGdkAARAEIRRKF 374
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISLI-------LANFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHG--GERNRDPKLL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 375 MPKTtgpdfpLIVTSY-----EMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAE 449
Cdd:cd18071 117 SKYD------IVLTTYntlasDFGAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKD 190
|
170 180
....*....|....*....|.
gi 1002296320 450 LWSLLNFILPDIFSSHQEFES 470
Cdd:cd18071 191 LGSLLSFLHLKPFSNPEYWRR 211
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
635-719 |
1.93e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 91.89 E-value: 1.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 635 DIIEYYLETKGLQVCRIDGSVKLEERRRQIAEFNDlnsSMNIFILSTRAGGLGINLTSADTCILYDSDWNPQMDLQAMDR 714
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNN---GKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77
|
....*
gi 1002296320 715 CHRIG 719
Cdd:smart00490 78 AGRAG 82
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
281-472 |
4.33e-22 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 96.11 E-value: 4.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWL---------ISLWQNGLNGILADQMGLGKTIQTIGF----LAHLKGKGLDgPYLIIAPLSTLSNWVNE 347
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFlhtvLLCEKLENFS-RVLVVCPLNTVLNWLNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 348 ISRFvpsMTGL-------IYHGDKAARAEIRRkFMPKTTGPDFPLIVTSYEM----AMSDAKHLAHyKWK---------- 406
Cdd:cd18068 80 FEKW---QEGLkdeekieVNELATYKRPQERS-YKLQRWQEEGGVMIIGYDMyrilAQERNVKSRE-KLKeifnkalvdp 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002296320 407 ---YVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWF 472
Cdd:cd18068 155 gpdFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRF 223
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
281-473 |
4.80e-22 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 95.68 E-value: 4.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWL----ISLWQNGLNG-ILADQMGLGKTIQTIGFLAHLKGKGLDGP------YLIIAPLSTLSNWVNEIS 349
Cdd:cd18066 1 LRPHQREGIEFLyecvMGMRVNERFGaILADEMGLGKTLQCISLIWTLLRQGPYGGkpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 350 RFVPSMTGLIYHGDKAARAEirrKFMpktTGPDFPLIVTSYEMAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKR 429
Cdd:cd18066 81 KWLGSERIKVFTVDQDHKVE---EFI---ASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTS 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1002296320 430 LPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFD 473
Cdd:cd18066 155 LSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYE 198
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
281-509 |
2.83e-21 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 93.70 E-value: 2.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLisLW---QNGLNGILADQMGLGKTIQTIGFL----------AHLKGKGLD-------------GPYLI 334
Cdd:cd18072 1 LLLHQKQALAWL--LWrerQKPRGGILADDMGLGKTLTMIALIlaqkntqnrkEEEKEKALTeweskkdstlvpsAGTLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 335 IAPLSTLSNWVNEISRFVPS--MTGLIYHGdkAARAEIRRKFMpkttgpDFPLIVTSYEMAMSDAKH---------LAHY 403
Cdd:cd18072 79 VCPASLVHQWKNEVESRVASnkLRVCLYHG--PNRERIGEVLR------DYDIVITTYSLVAKEIPTykeesrsspLFRI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 404 KWKYVIVDEGHRLKNSK------CLLLRELKRLpmdnklLLTGTPLQNNLAELWSLLNFILPDIFSSHQEFESWFDFSAK 477
Cdd:cd18072 151 AWARIILDEAHNIKNPKvqasiaVCKLRAHARW------ALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSR 224
|
250 260 270
....*....|....*....|....*....|..
gi 1002296320 478 GGEEeqedseekrkvdvvsKLHAILRPFLLRR 509
Cdd:cd18072 225 KGGE---------------RLNILTKSLLLRR 241
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
284-463 |
9.45e-20 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 88.50 E-value: 9.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 284 YQIKGVKWLISLWQNGLngILADQMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWVNEISRF----VPSMTGLI 359
Cdd:cd18011 4 HQIDAVLRALRKPPVRL--LLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQDKfglpFLILDRET 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 360 YhgdKAARAEIRRKFMPkttgpdFPLIVTSYEMAMSDAKHLAHYK---WKYVIVDEGHRLKNSKCL-------LLRELKR 429
Cdd:cd18011 82 A---AQLRRLIGNPFEE------FPIVIVSLDLLKRSEERRGLLLseeWDLVVVDEAHKLRNSGGGketkrykLGRLLAK 152
|
170 180 190
....*....|....*....|....*....|....
gi 1002296320 430 LpMDNKLLLTGTPLQNNLAELWSLLNFILPDIFS 463
Cdd:cd18011 153 R-ARHVLLLTATPHNGKEEDFRALLSLLDPGRFA 185
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
281-463 |
6.14e-15 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 75.46 E-value: 6.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISLwqnglNGILADQMGLGKTIQTIGF-LAHLKGKGLD-------------------------GPYLI 334
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALiLLHPRPDNDLdaadddsdemvccpdclvaetpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 335 IAPLSTLSNWVNEISRFVP-SMTGLIYHGDKAARAeirrkfmPKTTGPDF----PLIVTSY-----EMAMSDAKH----- 399
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQGVKKDGA-------LASPAPEIlaeyDIVVTTYdvlrtELHYAEANRsnrrr 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002296320 400 ------------LAHYKWKYVIVDEGHRLKNSKCLLLRELKRLPMDNKLLLTGTPLQNNLAELWSLLNFILPDIFS 463
Cdd:cd18070 149 rrqkryeappspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFC 224
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
303-729 |
1.56e-14 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 77.80 E-value: 1.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 303 ILADQMGLGKTIQT---IGFLAHLKGKGLdgpyLIIAPLSTLSNWVNEI-SRFvpSMTGLIYhgDKAARAEIRRKFMPKT 378
Cdd:NF038318 51 ILADEVGLGKTIEAglvLKYVLESGAKKI----LIILPANLRKQWEIELeEKF--DLESLIL--DSLTVEKDAKKWNKRL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 379 TGPDFPLIV-TSYEMAMSDAKHLAHYKWKYVIVDEGHRLKN-----SKCLLLREL-KRLPmdnKLLLTGTPLQNNLAELW 451
Cdd:NF038318 123 TDNKKVRIViTSYDYASKLMKRFPKVKWDFIIIDEAHNLRNvhkggKRAKNLYELtKGIP---KILLTATPLQNSLLDLY 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 452 SLLNFILPDIFSSHQEFESWF----DFSAkggeeeqedseekrkvdvvskLHAILRPFLLRRMKEDV-EHM-LPRKKEI- 524
Cdd:NF038318 200 GLVSFIDPRIFGSEKVFSKRYikdeDYSD---------------------LKRELSPVLYRTLRKDVaDYMqFKKRKCIt 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 525 -----------------------IIYANMTDHQ-------------------------KQIQNHLVEQT----------- 545
Cdd:NF038318 259 vdfelspdeielyvrvnnflkrdILYSIPTSNRtliilvirkllasssfalaetfevlKKRLEKLKEGTrsanaqegfdl 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 546 ----FDQYLHEKSE-------IVLRKPGIKAKLN------NLLIQLRKNCNhpdllesaydSSGLYPPVEKLLEqcgkFQ 608
Cdd:NF038318 339 fwsfVEDEIDESGFeekqdelYTRQKEFIQHEIDevdaiiDVAKRIKTNAK----------VTALKTALEIAFE----YQ 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 609 LLNRLlslllarKHKVLIFSQWTKVLDIIEYYLETKGLQVCRI--------DGSVKLEERRRQIAEFNDLNSSMNI---- 676
Cdd:NF038318 405 REEGI-------AQKVVVFTESKRTQKYIAEELRKSGYEGEDIllfngdfdDAMTKEIYRAWQVKNYGKANYGRSVeykh 477
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002296320 677 -----------FILSTRAGGLGINLTSADTCILYDSDWNPQMDLQAMDRCHRIGQTRPVHVYRL 729
Cdd:NF038318 478 aivdyfknnakILIVTDAGSEGLNLQFCNTVINYDLPWNPQKIEQRIGRCHRYGQKNDVVAINL 541
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
281-473 |
1.72e-13 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 70.46 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGVKWLISlwqNGLNGILADqMGLGKTIQTIGFLAHLKGKGLDGPYLIIAPLSTLSN-WVNEISRF--VPSMTG 357
Cdd:cd18013 1 PHPYQKVAINFIIE---HPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKWnhLRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 358 LIYHGDKAAraeiRRKFMpkTTGPDfpLIVTSYE-MAMSDAKHLAHYKWKYVIVDEGHRLKNSKCLLLRELKRL-PMDNK 435
Cdd:cd18013 77 SVAVGTERQ----RSKAA--NTPAD--LYVINREnLKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVrPVIKR 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1002296320 436 LL-LTGTPLQNNLAELWSLLNFI-----LPDIFSSHQefESWFD 473
Cdd:cd18013 149 LIgLTGTPSPNGLMDLWAQIALLdqgerLGRSITAYR--ERWFD 190
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
280-442 |
7.89e-09 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 55.37 E-value: 7.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 280 KLKSYQIKGVKWLISLWQNGLNGILAdQM--GLGKTIQTIGFLAHLKGKGLDGPYLIIAP-LSTLSNWVNEISRFVPSMT 356
Cdd:pfam04851 3 ELRPYQIEAIENLLESIKNGQKRGLI-VMatGSGKTLTAAKLIARLFKKGPIKKVLFLVPrKDLLEQALEEFKKFLPNYV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 357 --GLIYHGDKAaraeirrkfmpKTTGPDFPLIVTSYEMAMSDAK----HLAHYKWKYVIVDEGHRL----------KNSK 420
Cdd:pfam04851 82 eiGEIISGDKK-----------DESVDDNKIVVTTIQSLYKALElaslELLPDFFDVIIIDEAHRSgassyrnileYFKP 150
|
170 180
....*....|....*....|..
gi 1002296320 421 CLLLRelkrlpmdnkllLTGTP 442
Cdd:pfam04851 151 AFLLG------------LTATP 160
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
301-441 |
1.28e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 48.55 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 301 NGILADQMGLGKTIQ-TIGFLAHLKGKGldGPYLIIAPLSTLSNWVNEI--SRFVPSMTGLIYHGDKaaRAEIRRKFmpk 377
Cdd:cd00046 3 NVLITAPTGSGKTLAaLLAALLLLLKKG--KKVLVLVPTKALALQTAERlrELFGPGIRVAVLVGGS--SAEEREKN--- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002296320 378 tTGPDFPLIVTSYEMAMSDAKHLAHY---KWKYVIVDEGHR-LKNSK---CLLLRELKRLPMDNK-LLLTGT 441
Cdd:cd00046 76 -KLGDADIIIATPDMLLNLLLREDRLflkDLKLIIVDEAHAlLIDSRgalILDLAVRKAGLKNAQvILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
250-442 |
1.02e-05 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 49.25 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 250 EDCSPEDCTLTEEERWEKE--QARLVPLMTGGKLKSYQIKGV-KWLISLWQNGLNGILADQMGLGKTIQTIGFLAHLKGK 326
Cdd:COG1061 48 EDGRRLPEEDTERELAEAEalEAGDEASGTSFELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 327 GldgPYLIIAPLSTLSN-WVNEISRFVPSmtGLIYHGDKAaraeirrkfmpkttgPDFPLIVTSYEMAMSDA--KHLAHY 403
Cdd:COG1061 128 K---RVLVLVPRRELLEqWAEELRRFLGD--PLAGGGKKD---------------SDAPITVATYQSLARRAhlDELGDR 187
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1002296320 404 kWKYVIVDEGHRLKNSKcllLRE-LKRLPMDNKLLLTGTP 442
Cdd:COG1061 188 -FGLVIIDEAHHAGAPS---YRRiLEAFPAAYRLGLTATP 223
|
|
| HDA2-3 |
pfam11496 |
Class II histone deacetylase complex subunits 2 and 3; This family of class II histone ... |
530-736 |
8.09e-05 |
|
Class II histone deacetylase complex subunits 2 and 3; This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus.
Pssm-ID: 402894 Cd Length: 281 Bit Score: 45.40 E-value: 8.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 530 MTDHQKQIQNHLVE---QTFDQYL---HEKSEIVLRKpgikaKLNNLLIQLRKNCNHPDLLESAY--DSSGLYPPVEKLL 601
Cdd:pfam11496 12 MTSYQKELTEQIVSlhySDILKYCetsDSKEDISLIK-----SMTLCLENLSLVATHPYLLVDHYmpKSLLLKDEPEKLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 602 EQCGKFQLLNRLLSLLLARKHK----VLIFSQWTKVLDIIEYYLETKGLQVCRIDGSVKLEERRRQIAEFNDLNSSMNIF 677
Cdd:pfam11496 87 YTSGKFLVLNDLVNLLIERDRKepinVAIVARSGKTLDLVEALLLGKGLSYKRYSGEMLYGENKKVSDSGNKKIHSTTCH 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002296320 678 ILS-----TRAGGLGINlTSADTCILYDSDWNP-QMDLQAMDRCHRIGQTRPVhVYRLATSHSVE 736
Cdd:pfam11496 167 LLSstgqlTNDDSLLEN-YKFDLIIAFDSSVDTsSPSVEHLRTQNRRKGNLAP-IIRLVVINSIE 229
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
281-442 |
3.23e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 41.91 E-value: 3.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 281 LKSYQIKGV-KWLISlwQNGLNGILADQMGLGKTIQTIGFLAHLKgkglDGPYLIIAP-LSTLSNWVNEISRFVP-SMTG 357
Cdd:cd17926 1 LRPYQEEALeAWLAH--KNNRRGILVLPTGSGKTLTALALIAYLK----ELRTLIVVPtDALLDQWKERFEDFLGdSSIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 358 LIYHGDKAARaeirrkfmpkttgPDFPLIVTSYEMAMSDAKHLAHYK--WKYVIVDEGHRL---KNSKClllreLKRLPM 432
Cdd:cd17926 75 LIGGGKKKDF-------------DDANVVVATYQSLSNLAEEEKDLFdqFGLLIVDEAHHLpakTFSEI-----LKELNA 136
|
170
....*....|
gi 1002296320 433 DNKLLLTGTP 442
Cdd:cd17926 137 KYRLGLTATP 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
309-442 |
1.13e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 40.69 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 309 GLGKT-IQTIGFLAHLKGKGLDGPYLIIAPLSTLSNWV----NEISRFVPSMTGLIYHGDKaaRAEIRRKFmpktTGPDf 383
Cdd:pfam00270 24 GSGKTlAFLLPALEALDKLDNGPQALVLAPTRELAEQIyeelKKLGKGLGLKVASLLGGDS--RKEQLEKL----KGPD- 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002296320 384 pLIVTSYEMAMSDAKHLAHYK-WKYVIVDEGHRL--KNSKCLLLRELKRLPMDNK-LLLTGTP 442
Cdd:pfam00270 97 -ILVGTPGRLLDLLQERKLLKnLKLLVLDEAHRLldMGFGPDLEEILRRLPKKRQiLLLSATL 158
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
299-444 |
1.82e-03 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 39.87 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 299 GLNGILADQMGLGKTIQT-IGFLAHLKGKGLDGPYLI-IAPLSTLSN--------WVNEISrfvPSMTGLIYHGDKAARa 368
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAfLPALSSLADEPEKGVQVLyISPLKALINdqerrleePLDEID---LEIPVAVRHGDTSQS- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 369 eIRRKFMPKTtgPDFpLIVT--SYEMAMSDAKH---LAHYKwkYVIVDEGHRLKNSK--CLLLRELKRLpmdnkLLLTGT 441
Cdd:cd17922 77 -EKAKQLKNP--PGI-LITTpeSLELLLVNKKLrelFAGLR--YVVVDEIHALLGSKrgVQLELLLERL-----RKLTGR 145
|
...
gi 1002296320 442 PLQ 444
Cdd:cd17922 146 PLR 148
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
135-271 |
2.12e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.05 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 135 DAMKEEEEKLHDARVKAEEEEvaRKREEAARLAFDPNARfnKLDELLSQTqlysefllEKMETIADVEGVQTHAEEEPVE 214
Cdd:PTZ00121 1611 EAKKAEEAKIKAEELKKAEEE--KKKVEQLKKKEAEEKK--KAEELKKAE--------EENKIKAAEEAKKAEEDKKKAE 1678
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1002296320 215 EKKNGRGRKRKATSAPKYNDKKAKKAVAVMLTRSHEDCSPEDCTLTEEERWEK-EQAR 271
Cdd:PTZ00121 1679 EAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKaEEAK 1736
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
624-690 |
4.60e-03 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 38.31 E-value: 4.60e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002296320 624 VLIFSQWtKVLDIIEYYLETKGLQVCRIDGSVKLEERRRQIAEFNDLNSSMNIfILSTRAGGLGINL 690
Cdd:cd18805 22 VVAFSRK-DIFSLKREIEKRTGLKCAVIYGALPPETRRQQARLFNDPESGYDV-LVASDAIGMGLNL 86
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| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
138-240 |
5.85e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.51 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 138 KEEEEKLHDARVKAEEEEVARKREEAARLAFDPNARFNKLDELLSQTQLYSEFLLEKMETIADVEGVQTHAEEE--PVEE 215
Cdd:PTZ00121 1641 KEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEkkKAEE 1720
|
90 100
....*....|....*....|....*.
gi 1002296320 216 -KKNGRGRKRKATSAPKYNDKKAKKA 240
Cdd:PTZ00121 1721 lKKAEEENKIKAEEAKKEAEEDKKKA 1746
|
|
| DBINO |
pfam13892 |
DNA-binding domain; DBINO is a DNA-binding domain found on global transcription activator ... |
139-197 |
6.60e-03 |
|
DNA-binding domain; DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.
Pssm-ID: 464024 [Multi-domain] Cd Length: 134 Bit Score: 37.52 E-value: 6.60e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002296320 139 EEEEKlhDARVKAE-EEEVARKREEAARLAfDPNARfnKLDELLSQTQLYSEFLLEKMET 197
Cdd:pfam13892 79 EKEER--ELRKRAEkEALEQAKKEEELREA-KRQQR--KLNFLITQTELYSHFMGKKLKT 133
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