|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
13-404 |
0e+00 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 532.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 13 LIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIF 92
Cdd:cd17385 1 LISLALANFSSMICYSILAPFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 93 FGLLDKVEGHYPFIILSFVIRIVEALGNAAFLTASFAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGALYQVGGYTT 172
Cdd:cd17385 81 FGFLDRVPDGTVFIALCFLVRIVEAVGFAAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 173 PFAVLGSALFLAAVMTAFVLPTHDNDeqDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSPVVL 252
Cdd:cd17385 161 PFLVLGCLLLLTVPLNMFILPRYDDD--PSPKSGSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGQV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 253 GLMFIINGGTYAITAPAWGWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPFIPGTTIIWLTILGLVIHGLGMSAQLVASF 332
Cdd:cd17385 239 GLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVIGSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTF 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1000763646 333 TDALRISISYGFPNNLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:cd17385 319 PELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-404 |
3.61e-45 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 162.36 E-value: 3.61e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 16 ISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGL 95
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 96 LDkvegHYPFIIlsfVIRIVEALGNAAFLTASFAIIAKEFP-DNVATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPF 174
Cdd:cd17325 81 AT----SYWQLL---LARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 175 AVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMK-----VLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLS 248
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRsglrlLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 249 PVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFclvgpaPFIPGTTIIWLTILGLVIHGLGMSAQL 328
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI-LIGLLLSAVAL------LLLPLATSFWLLLLLLALLGLGLGLVF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1000763646 329 VASFTDALRISISygfpnnlETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLhLIVGIVATLFL 404
Cdd:cd17325 307 PATLALLADIVPP-------EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-366 |
1.76e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 121.23 E-value: 1.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 6 TKRQWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILT 85
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 86 TGTCAIFFGLLDkvegHYPFIILSfviRIVEALGNAAFLTASFAIIAKEFP-DNVATTFASLETFFGLGLIVGPTVGGAL 164
Cdd:COG2814 85 FALGSLLCALAP----SLWLLLAA---RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 165 YQVGGYTTPFAVLGSALFLAAVMTAFVLPtHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHL-R 243
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLP-ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 244 QFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFCLVGPAPFipgttiIWLTILGLVIHGLG 323
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL-LIGLLLLALGLLLLALAGS------LWLLLLALFLLGFG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1000763646 324 MSAQLVASFTDALRIsisygFPNnlETYGLISGLWTSTFALGA 366
Cdd:COG2814 310 FGLLFPLLQALVAEL-----APP--EARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-370 |
1.42e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.50 E-value: 1.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 16 ISIADFANAICVSLQAPFYP-HEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFG 94
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 95 LLDKveghypfIILSFVIRIVEALGNAAFLTASFAIIAKEFPD-NVATTFASLETFFGLGLIVGPTVGGALYQVGGYTTP 173
Cdd:pfam07690 81 FASS-------LWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 174 FAVLGSALFLAAVMTAFVLPTHDND-----EQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLS 248
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKrpkpaEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 249 PVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVATVIGCVLVMVGFCLVgpapFIPGTTIIWLTILGLVIHGLGMSAQL 328
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL----LLSLTLSSLWLLLALLLLGFGFGLVF 309
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1000763646 329 VASFTDALRISisygfpnNLETYGLISGLWTSTFALGAFIGP 370
Cdd:pfam07690 310 PALNALVSDLA-------PKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-404 |
2.79e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 107.27 E-value: 2.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 7 KRQWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTT 86
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 87 GTCAIFFGLLDkveghyPFIILsFVIRIVEALGNAAFLTASFAIIAKEFP-DNVATTFASLETFFGLGLIVGPTVGGALY 165
Cdd:COG2223 81 GIGLLLLALAV------SYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 166 QVGGYTTPFAVLGSALFLAAVMTAFVL--PTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLR 243
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLrdPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 244 -QFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVaTVIGCVLVMVGFCLVgpaPFIPGTtiIWLTILGLVIHGL 322
Cdd:COG2223 234 dQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV-LLIVFALMALGLLLL---ALALGS--LWLFLVLFLLLGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 323 GMSAQLVASFTDALRIsisygFPnnLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATL 402
Cdd:COG2223 308 ALGGGNGAVFALVPDI-----FP--TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
..
gi 1000763646 403 FL 404
Cdd:COG2223 381 LL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
16-404 |
5.64e-25 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 106.14 E-value: 5.64e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 16 ISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGL 95
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 96 LDKveghypfIILSFVIRIVEALGNAAFLTASFAIIAKEFP-DNVATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPF 174
Cdd:cd17489 81 ATS-------VALLLVLRLIHGIGWGAFTTAAATLVADIIPpSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 175 AVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSpvVLGL 254
Cdd:cd17489 154 IVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 255 MFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFCLVGPAPFipgttiIWLTILGLVIHGLGMSAQLVASFTD 334
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVI-IPGLLLLALGLLLLSFAGS------PWMLLLAAVLYGLGFGLLFPALQAL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 335 ALRISISYGFpnnletyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:cd17489 305 AVDLVPPHRR-------GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-404 |
4.73e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 103.41 E-value: 4.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 3 RQFTKRQWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGG 82
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 83 ILTTGTCAIFFGLLDkveghyPFIILsFVIRIVEALGNAAFLTASFAIIAKEFPDNV-ATTFASLETFFGLGLIVGPTVG 161
Cdd:COG2271 82 LLLWGLATLLFGFAT------SFWQL-LLLRFLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 162 GALYQVGGYTTPFAVLGSALFLAAVMTafvlpthdndeqdtqdsggfmkvlripgVMVAAASIIVTSMSIGFLQATLEPH 241
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALLR----------------------------FWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 242 LRQ-FNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVATVIGCVLVMVGFCLVgpAPFIPGTtiiWLTILGLVIH 320
Cdd:COG2271 207 LVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLL--LALLPSP---ALAIALLFLA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 321 GLGMSAQLVASFTdalriSISYGFPNNLetYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNAsMFIVLLHLIVGIVA 400
Cdd:COG2271 282 GFGLGGAFGLLWA-----LAAELFPKKA--RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA-FLLLAALALLAALL 353
|
....
gi 1000763646 401 TLFL 404
Cdd:COG2271 354 ALLL 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-400 |
2.48e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.57 E-value: 2.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 21 FANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGLLdkve 100
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA---- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 101 ghyPFIILSFVIRIVEALGNAAFLTASFAIIAKEFPDNVATT-FASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGS 179
Cdd:cd06174 82 ---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRaLGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 180 ALFLAAVMTAFVLPTHDNDEQDTQDS---------GGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSP 249
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNeeassksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 250 VVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPFipgttiIWLTILGLVIHGLGMSAQLV 329
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS------LLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1000763646 330 ASFTDALRISISygfpnnlETYGLISGLWTSTFALGAFIGPSIAGILLD-TIGFRNASMFIVLLHLIVGIVA 400
Cdd:cd06174 313 LSFALIAELFPP-------EIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-404 |
8.16e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 91.47 E-value: 8.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 3 RQFTKRQWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGG 82
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 83 ILTTGTCAIFFGLLDkveGHYPFIILSFVIRIVEALGNAAFLtasfAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGG 162
Cdd:COG2807 90 LLLLAAGLLLRSLAP---SVALLLAGTALIGAGIAVGNVLLP----GLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 163 ALYQVGGYTTPFAVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHL 242
Cdd:COG2807 163 PLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 243 RQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPfiPGTTIIWLTILGLvihGL 322
Cdd:COG2807 243 RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAP--GSLPWLWAVLLGL---GQ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 323 GMSAQLVASFTdALRISisygfpnNLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATL 402
Cdd:COG2807 318 GGLFPLALTLI-GLRAR-------TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
..
gi 1000763646 403 FL 404
Cdd:COG2807 390 LA 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
32-400 |
5.52e-19 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 88.02 E-value: 5.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 32 PFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGLLdkveghyPFIILSFV 111
Cdd:cd17330 20 PFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS-------RNLWLLFL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 112 IRIVEALGNAAFLTASFAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFV 191
Cdd:cd17330 93 ARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 192 LPThdndeqdtqdsggfmkvlripgvmvaAASIIVTSMSIGFLQATLEPHL-----RQFNLSPVVLGLMFIINGGTYAIT 266
Cdd:cd17330 173 LPP--------------------------LRRLLLVYFLIALAFAGLESVFslflkDRFGFSPSQIGLLLALVGIAGILA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 267 -APAWGWLcDKYSKPKVATVIGCVLVMVGFCLVGPAPFIPgttiiwLTILGLVIHGLGmsaqlVASFTDALRISISygfp 345
Cdd:cd17330 227 qLLLIPRL-AKRLGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFG-----TGIVFPALSALLS---- 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1000763646 346 NNLETY--GLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVA 400
Cdd:cd17330 291 KSVPSKeqGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-400 |
6.56e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 88.37 E-value: 6.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 6 TKRQWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILT 85
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 86 TGTCAIFFGLLdkveGHYPFIILSFVIRiveALGNAAFLTASFAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGALY 165
Cdd:COG0738 83 MALGLLLFALA----PSYPLLLLALFLL---GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 166 QVG---GYTTPFAVLGSALFLAAVMTAFV-LP-THDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEP 240
Cdd:COG0738 156 LLGlslSWHLPYLILAVLLLLLALLFLRSkLPeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 241 HLRQ-FNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSkPKVATVIGCVLVMVGFCLVGPAPfipgttIIWLTILGLVI 319
Cdd:COG0738 236 YLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG-PVRLLRLSALLAAVGLLLALLAP------GPWLALIGLAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 320 HGLGMSAQLVASFTDALRISISYGfpnnletyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIV 399
Cdd:COG0738 309 VGLGLSLMFPTIFSLALDGLGKRT--------AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
.
gi 1000763646 400 A 400
Cdd:COG0738 381 A 381
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
24-400 |
2.15e-18 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 86.46 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 24 AICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGLLDKveghy 103
Cdd:cd17477 9 GLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 104 pfIILSFVIRIVEALGNAAFLTASFAIIAKEFPDNV-ATTFASLETFFGLGLIVGPTVGGALYQVGGytTPFAVLGSALF 182
Cdd:cd17477 84 --PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENrGRVLGLYSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 183 LAAVMTAFVLPTHDNDEQdtQDSGGFMKVLRI--PGVMVAAASIIVTSMSIGFLQAtlepHLRQFNLSP--VVLGLMFII 258
Cdd:cd17477 160 LALVPLLLTRRAAPEIEE--AESISLRRLLRIapLALLGAFVAGFLEGAFYSLLPL----YGLRLGLSVaqAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 259 NGGtyAITAPAWGWLCDKYSKPKVAtvIGCVLVMVGFCLVGP-APFIPGTTIIWLTILGLVIHG---LGMsAQLVASFTD 334
Cdd:cd17477 234 LGG--LLLQWPLGWLADRFDRRRVL--LGCALLGALAALLLPlVPGLPLALLVLLFLWGGAAGPlytLAL-ALAGDRLPG 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1000763646 335 ALRISISYGFpnnletyglisglwTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVA 400
Cdd:cd17477 309 DELVAANAAL--------------LLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
10-402 |
1.17e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 85.34 E-value: 1.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 10 WLTLIVISIADFANAICVSLQ----APFYPHEAekkGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPK-------LL 78
Cdd:COG2211 9 LKEKLAYGLGDLGLNLAFGLLsaylLYFYTDVL---GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 79 FngGILTTGTCAIFFGLLDKVEGHYPFIILsFVIRIVEALGNAAFLTASFAIIAKEFPDNV--ATTFASLETFFGLGLIV 156
Cdd:COG2211 86 I--GAIPLALSFVLLFTAPDLSPTGKLIYA-LVTYLLLGLAYTLVNIPYSALGAELTPDYEerTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 157 GPTVGGALY------QVGGYTTPFAVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMK-VLRIPGVMVAAASIIVTSM 229
Cdd:COG2211 163 ASVLPPPLVaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKaLLKNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 230 SIGFLQATLEPHLRQ-FNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFCLVgpapFIPGTT 308
Cdd:COG2211 243 ALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF-IIGLLLAALGLLLL----FFLGPG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 309 IIWLTILGLVIHGLGMSAQLVASF---TDAlrisISYG-FPNNLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFR- 383
Cdd:COG2211 318 NLWLLLVLAALAGIGLGAILVLPWamlADV----VDYDeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVa 393
|
410 420
....*....|....*....|....*
gi 1000763646 384 ------NASMFIVLLHLIVGIVATL 402
Cdd:COG2211 394 gaaqspSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-402 |
1.47e-17 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 84.19 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 24 AICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFnggILTTGTCAIFFGLLDKVEGhY 103
Cdd:cd17331 13 ATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAAL---VLSFLSSALSYLLLAFASS-V 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 104 PFIILSFVirivEALGNAAFLTASFAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFL 183
Cdd:cd17331 89 PMLFLSRL----PSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 184 AAVMTAFVLPTH-----------DNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLR-QFNLSPVV 251
Cdd:cd17331 165 SIVLVILLIPSNtkskrekeakeSASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMdFFGLTPEE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 252 LGLMFIINGGTYAIT-APAWGWLCDKYSKPKVatVIGCVLVM-VGFCLVGPAPFipgttiIWLTILGLVIHGLGMSAQLV 329
Cdd:cd17331 245 NGYLMSYAGVLGMVVqGLLVGPLTKRFGERSL--LKLSVALLaIGYLLLAFVTT------VWQLLVLLLPLVIGGSVLYT 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1000763646 330 ASfTDALRISISYgfpnnlETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATL 402
Cdd:cd17331 317 VI-TSLLTKAVPP------EDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
49-390 |
4.12e-17 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 83.01 E-value: 4.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 49 GLVFGIFEFVVFIISPIYGQHLNRLGPKL-LFNGGILTTGTCAIF-FGlldkveGHYPFIilsFVIRIVEALGNAAFLTA 126
Cdd:cd17384 34 GLLFASKALVQLITNPIVGPLTNRIGYSLpMFVGFVIMFISTLLFaFG------ESYGVL---FLARALQGVGSACSSVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 127 SFAIIAKEFPDN------VATTFASLetffGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFVLPThDNDEQ 200
Cdd:cd17384 105 GMGMLASLYPDDkergkaMGIALGGL----ALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQP-SVKSE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 201 DTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSK 279
Cdd:cd17384 180 ESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMEtMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 280 PKVAtVIGcvLVMVGFCLVgpapFIPGTTiiwlTILGLVI--HGLGMSAQLV--------ASFTDALRISIsygfpnnle 349
Cdd:cd17384 260 WLCS-LLG--MLLVGISLI----LIPLAK----NIYGLIIphFGLGLGIGMVdssmmpllAYLVDLRHSSV--------- 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1000763646 350 tYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRnASMFIV 390
Cdd:cd17384 320 -YGSVYAIADVAFCLAFALGPSLGGAIVKSIGFP-WLMRII 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-402 |
3.81e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.90 E-value: 3.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 42 GASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPK--LLFNGGILTTGTCAIFFGlldkveghyPFIILSFVIRIVEALG 119
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRrlLLVLLLLFILGNLLAALA---------PSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 120 NAAFLTASFAIIAKEFPDN-VATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFVLPTHDND 198
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEkRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 199 E-QDTQDSGGFMKVLRIPGVMVA--AASIIVTSMSIGFlqATLEPHL-RQFNLSPVVLGLMFIINGGTYAITAPAWGWLC 274
Cdd:cd17324 181 KpGSLGLLSSLLLLLRNPRLRLAylITFLLFGGFFALY--TYLAPFLtDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 275 DKYSKpKVATVIGCVLVMVGFCLVGPAPfipgttIIWLTILGLVIHGLGMSAQLVASFTDALRISisygfpnnLETYGLI 354
Cdd:cd17324 259 DRGGR-RALLIALLLLAAALLLLTLLGP------SPLLLLVGLVLWGLGFFAAHSALQTRVLRLA--------PEARGLA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1000763646 355 SGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLhLIVGIVATL 402
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAAL-LLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-403 |
4.37e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.92 E-value: 4.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 27 VSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGLLDKveghYPFI 106
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS----FALL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 107 IlsfVIRIVEALGNAAFLTASFAIIAKEFPDN-VATTFASLETFFGLGLIVGPTVGGALYQVGgYTTPFAVLGSALFLAA 185
Cdd:cd17474 91 L---AGRALQGIGAAGLGPLALTLIGDLFEGGeRAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 186 VMTAFVL--PTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSPVVLGLMFIINGGT 262
Cdd:cd17474 167 LAILFLLpePKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 263 YAITAPAWGWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPfipgttIIWLTILGLVIHGLGMSAQLvASFTDAlrisISY 342
Cdd:cd17474 247 LALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP------SLALLLIAIVLFGLGLGLNL-PLLTTL----VTE 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1000763646 343 GFPNnlETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLF 403
Cdd:cd17474 316 LAPE--EERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-404 |
6.64e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 76.07 E-value: 6.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 13 LIVISIADFANaicVSLQAPFYPHEAekkGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIF 92
Cdd:cd17319 11 AYVINYLDRVN---ISVAAPTIMKDL---GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 93 FGLldkVEGHYPFIILSFVIRIVEAlgnaAFLTASFAIIAKEFPDNVATTFASLETFF-GLGLIVGPTVGGALYQVGGYT 171
Cdd:cd17319 85 TGF---ATSLTSLYVLRFLLGVAEA----GFFPGAIKALAEWFPARERGRATGLFNSGaPLGAAIGPPLSGWLLLLFGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 172 TPFAVLGSALFLAAVMTAFVLPThdndeqdtqdsggfmkvlripgVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSPV 250
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYLRQ----------------------VWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 251 VLGLMFIINGGTYAITAPAWGWLCDKYS--KPKVATVIGCVLVMVGFCLVGPapfipgTTIIWLTILGLVIHGLGMSAQL 328
Cdd:cd17319 216 QVGLLAAIPFLAGAIGMILGGRLSDRLLrgARRLVIIIGLLLAAVGLLLAYL------TTSPVVAVILLSLAGFGIGAAS 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1000763646 329 VASFTDALRISisygfpnNLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:cd17319 290 PVFWSLPADLL-------PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-399 |
5.00e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 73.42 E-value: 5.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 13 LIVISIADFANAICVSLQAPFYP-HEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFnggILTTGTCAI 91
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVM---LAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 92 FFGLLDKVEGHYPFIILSFVIriveALGNAAFLTASFAIIAKEFPD-NVATTFASLETFFGLGLIVGPTVGGALYQVGgY 170
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLT----GFGGGLFEPASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-F 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 171 TTPFAVLGSALFLAAVMTAFVLP---THDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHL-RQFN 246
Cdd:cd17329 153 RLLFLAAAVLFLLAALVLLFLLPetrPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVvEILG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 247 LSPVVLGLMFIINGGTYAI-TAPAWGWLCDKysKPKVATVIGCVLVMVGFClvgpapFIPGTTIIWLTILGLVIHGLGMS 325
Cdd:cd17329 233 LGESLLGLLLALNALLIVLlQFPVARLVERF--RLRKILMIGILLFAIGFA------VLAFANTLAVLILAMIVLTLGEM 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000763646 326 aqLVASFTDALRISISygfpnNLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIV 399
Cdd:cd17329 305 --LVFPAVQTLVAALA-----PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
42-404 |
5.82e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 70.29 E-value: 5.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 42 GASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGIL--TTGTCAIFFglLDKveghYPFIILSfviRIVEALG 119
Cdd:cd17473 31 PNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLlyGIGGVAGLF--LDS----LYALLAS---RALLGIG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 120 NAAFLTASFAIIAKEFPDNVATTFASLET-FFGLGLIVGPTVGGALYQVGgYTTPFAVLGSALFLAaVMTAFVLPTHDND 198
Cdd:cd17473 102 VAGIMTLATALIGDYFEGEERAKMLGLQSaAMSLGGVVFLLLGGALAEIG-WRAPFLVYLLALPVL-ILVLLFLPEPARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 199 EQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEP-HLRQFNL-SPVVLGLMFIINGGTYAITAPAWGWLCDK 276
Cdd:cd17473 180 SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPfLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 277 YSKPKVaTVIGCVLVMVGFCLVGPAPFIpgttiiWLTILGLVIHGLGMSAQLVASFTDALRISisygfpnNLETYGLISG 356
Cdd:cd17473 260 LGKRRL-LAIGFALMALGFLLLALASGL------WVVLLGAILAGLGFGLLLPTLNSWAMSLV-------PPELRGRAMG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1000763646 357 LWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:cd17473 326 IVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
48-377 |
8.01e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.89 E-value: 8.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 48 YGLVFGIFefvvfiiSPIYGQHLNRLGPKLLFNGGI----LTTGTCAIFFGLldkveghyPFIILSfviRIVEALGNAAF 123
Cdd:cd17321 40 YLLAFAAL-------LLLAGRLGDRFGRKRVFLIGLalfgLASLLCALAPSL--------AFLIAA---RALQGIGAAAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 124 LTASFAIIAKEFPDN-VATTFASLETFFGLGLIVGPTVGGALYQVGGY------TTPFAVLG---SALFLAAVMTAFvlp 193
Cdd:cd17321 102 MPASLALIAATFPGErRGRALGLWGAVVGIGAALGPLLGGLLLELFGWrwifliNVPIGLVAlllARTFSGAVLAAF--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 194 thdndeqdtqdsggfmkvlripgVMVAAASIIVTSMSIgFLQATLephlrqfNLSPVVLGLMFIINGGTYAITAPAWGWL 273
Cdd:cd17321 179 -----------------------LLGAALGGLLFLLPL-YLQGVL-------GYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 274 CDKYSkPKVATVIGCVLVMVGFCLVgpaPFIPGTTIIWLTILGLVIHGLGMSAQLVASFTDALRISISygfpnnlETYGL 353
Cdd:cd17321 228 ADRFG-PRLVLVAGLLLTAVGLLLL---ALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPK-------EKAGA 296
|
330 340
....*....|....*....|....
gi 1000763646 354 ISGLWTSTFALGAFIGPSIAGILL 377
Cdd:cd17321 297 ASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-403 |
3.46e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 68.03 E-value: 3.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 42 GASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGLLDKVEGHYPFIIlsFVIRIVEALGNA 121
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLL--LVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 122 AFLTASFAIIAKEFPDNVATTFASL-ETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFV------LPT 194
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALnSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIrrpppaAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 195 HDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSPVVLGLMFIINGGTYAITAPAWGWL 273
Cdd:cd06173 188 ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 274 CDKysKPKVATVIGCVLVMVGFCLVgpapfIPGTTIIWLTILGLVIHGLGMSAQLVASFTdALRISIsygfPNNLetYGL 353
Cdd:cd06173 268 SKR--RRRGRLLLIGALLLGLALLV-----LGLSPSLWLLLAALFLLGLAGGLFNVPLNT-LLQLRV----PDEL--RGR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1000763646 354 ISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLF 403
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
213-404 |
6.19e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 66.92 E-value: 6.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 213 RIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVM 292
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-LLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 293 VGFCLVGPAPfipgtTIIWLtILGLVIHGLGMSAQLVASFTDALRIsisygFPNnlETYGLISGLWTSTFALGAFIGPSI 372
Cdd:COG2814 87 LGSLLCALAP-----SLWLL-LAARFLQGLGAGALFPAALALIADL-----VPP--ERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190
....*....|....*....|....*....|..
gi 1000763646 373 AGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:COG2814 154 GGLLADLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
18-384 |
1.55e-10 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 62.67 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 18 IADFANAICVSLQAPFYPHEAEKKGASATEY-----GLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIF 92
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 93 FGLLDKVeghYPFIILSFVIRIVealgnAAFLTASFAIIAKEFPDNVA-TTFASLETFFGLGLIVGPTVGGALYQVGGYT 171
Cdd:cd17391 83 MAFVTNV---WQLLILRLLQGVF-----SGYVPNATALIASQTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 172 TPFAVLGSALFLAAVMTAF-VLPTHDNDEQDTQDSggFMKVLRI---PGVMVaaaSIIVTSMSIGFLQATLEPHL----- 242
Cdd:cd17391 155 NVFFITGGLLFLAFLLTLFfVKEDFKPVEKKKMVS--TKEVWNSvpnPSLLI---SLFVTTFIIQLANQSIEPILtlyir 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 243 ----RQFNLSpVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVatVIGCVLVMVGFcLVGPAPFIPGTTIIWLTILglv 318
Cdd:cd17391 230 qlmgDASNLA-FISGLVFSATGVSSLLSAPRLGKLGDRIGHHRI--LLGALLASALL-YIPQAFVQTPWQLGILRFL--- 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1000763646 319 iHGLGMSAqLVASFTDALRISISYgfpnnlETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRN 384
Cdd:cd17391 303 -LGLATGG-LLPAINSLLAKITPK------EVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRA 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
16-402 |
1.90e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.57 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 16 ISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGL 95
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 96 LDkveGHYPFIILSFVIriveALGNAAFLTASFAIIAKEFPDNVAtTFASLETFFG-LGLIVGPTVGGALYQVGGYTTPF 174
Cdd:cd17478 81 AP---NYWLLLLLVALA----GIGSAAFHPEGARLASQAAGGRRG-LAMSIFSVGGnLGFALGPLIAAALVALFGGLGLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 175 AVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGF--LQATLEPHLRQFNLSPVVL 252
Cdd:cd17478 153 ILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLssLTTFLPFYLVQRGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 253 GLM-FIINGGTyAITAPAWGWLCDKYSKPKV--ATVIGCVLVMVGFCLVGPapfipgttiiWLTILGLVIHGLGMSAQLV 329
Cdd:cd17478 233 GLLlSLFLFAG-AIGTLIGGPLSDRFGRRRViiASLLLAAPFLLLFLLTPG----------IWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000763646 330 ASFTDALRIsisygFPNNLetyGLISGL-WTSTFALGAfIGPSIAGILLDTIGFRNASMFIVLLhLIVGIVATL 402
Cdd:cd17478 302 VTVVLAQEL-----LPGNV---GLASGLmMGLSFGLGG-IGAPVLGALADAFGLESVLLILALL-PLLGALLAF 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-405 |
2.12e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 62.29 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 9 QWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGT 88
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 89 CAIFFGLLDKVEGHYpfiiLSFVIRIVEALGNAAFLTASfAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGALYQVG 168
Cdd:cd17355 81 GLVLLALATSLWQLY----LLWGLLGGGGAGTLAAVAFA-TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 169 GYTTPFAVLGSALFLAAVMTAFVL-------PTHDNDEQDTQDSGGFMK-VLRIPGVMVAAASIIVTSMSIGFLQATLEP 240
Cdd:cd17355 156 GWRTALLVLALLALLVLVPVLLLLrrrpadlALRAYDDASPASPGSTLKeALRSASFWLLALAFFLCGFAVVGLIVHLVP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 241 HLRQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVATVIgCVLVMVGFCLVGPAPFIPGTTIIWLTILGLVIH 320
Cdd:cd17355 236 YLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAAS-YALRALGLALLLLLPFPPLALLLFAALFGLGWG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 321 GLG-MSAQLVASFtdalrisisYGfpnnLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGfrNASMFIVLLHLIVGIV 399
Cdd:cd17355 315 ATVpLTAALAARY---------FG----ARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG--SYTAAWALAVALGLIA 379
|
....*.
gi 1000763646 400 ATLFLT 405
Cdd:cd17355 380 ALLVLP 385
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
16-404 |
5.53e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 61.02 E-value: 5.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 16 ISIADFANAICVSLQAPFYP-HEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGP--KLLFNGGILTTGTCAIF 92
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSlFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDrkPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 93 FGLLDkveghypFIILSFVIRIVEALGNAAF--LTASFAIIAKEFPDNVATTF-ASLETFFGLGLIVGPTVGGALYQVGG 169
Cdd:cd17471 81 AFLRN-------YWVLLLVGVVLLSLGAAAFpqLFALAREYADRSSGRDATLFnSVLRAAFSLAWVIGPPLAFLLLDVLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 170 YTTPFAVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIV--TSMSIGFLQATLepHL-RQFN 246
Cdd:cd17471 154 FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLlfAANSMYIIAMPL--YVtNELG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 247 LSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVatVIGCVLVMVGFCLvgpapFIPGTTIIWLTILGL--------V 318
Cdd:cd17471 232 GSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRL--LLAGFLAGVLFYL-----GLALATSLWQLIALQllnaifigI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 319 IHGLGMSAqlvasFTDALRISIsygfpnnletyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRnaSMFIVLlhLIVGI 398
Cdd:cd17471 305 TAGLGISY-----FQDLMPGQP-----------GLATTLYSNASRIGSLLGGLLAGVIAQYFGYR--AVFLVC--AVLAL 364
|
....*.
gi 1000763646 399 VATLFL 404
Cdd:cd17471 365 LALVLL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-273 |
6.45e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.21 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 6 TKRQWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILT 85
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 86 TGTCAIFFGLLdkveghyPFIILSFVIRIVEALGNAAFLTASFAIIAKEFPDNVATTFASL-ETFFGLGLIVGPTVGGAL 164
Cdd:COG0477 89 FGLASLLCGLA-------PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLwGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 165 YQVGGYTTPFAVLGSALFLAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ 244
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260
....*....|....*....|....*....
gi 1000763646 245 FNLSPVVLGLMFIINGGTYAITAPAWGWL 273
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLL 270
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
113-336 |
7.60e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 60.67 E-value: 7.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 113 RIVEALGNAAFLTASFAIIAKEFPDNVATT-FASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFV 191
Cdd:cd17320 94 RFLQGLGAAAGSVVARAIVRDLYSGAELAKiFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 192 LP-THDNDEQDTQDS---GGFMKVLRIPGVMVAAASIIVTSMSI-GFLQATLEPHLRQFNLSPVVLGLMFIINGGTYAIT 266
Cdd:cd17320 174 LPeTLPEEKRKPLLSsllRAYKRVLKNRRFLGYALALGLSFAGLfAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG 253
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 267 APAWGWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPFIPGTtiIWLTILGLVIHGLGMSAQLVASFTDAL 336
Cdd:cd17320 254 SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLS--LWPLVAPLFLIFFGFGLIFPNATSLAL 321
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
214-408 |
1.01e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 214 IPGVMVAAASIIVTSMSIGFLQATLEphlRQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSkPKVATVIGCVLVMV 293
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQ---ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG-RRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 294 GFCLVGpapFIPGttiIWLTILGLVIHGLGMSAQLVASFTdalriSISYGFPNnlETYGLISGLWTSTFALGAFIGPSIA 373
Cdd:COG2271 88 ATLLFG---FATS---FWQLLLLRFLLGLGEAGFFPAALK-----LIAEWFPP--KERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190
....*....|....*....|....*....|....*
gi 1000763646 374 GILLDTIGFRNASMFIVLLHLIVGIVATLFLTCCN 408
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALLRFWLLALAY 189
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-405 |
3.97e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 3.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 221 AASIIVTSMSIGFLQATLEPHL-RQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFCLVG 299
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL-LIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 300 papFIPGttiIWLTILGLVIHGLGMSAQLVASFTDALRISisygfpnNLETYGLISGLWTSTFALGAFIGPSIAGILLDT 379
Cdd:pfam07690 81 ---FASS---LWLLLVLRVLQGLGAGALFPAALALIADWF-------PPEERGRALGLVSAGFGLGAALGPLLGGLLASL 147
|
170 180
....*....|....*....|....*.
gi 1000763646 380 IGFRNASMFIVLLHLIVGIVATLFLT 405
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLPRP 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
42-399 |
1.99e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 42 GASATEYGLVFGIFEFVVFIISPIYGQHLNRLGP-KLLFNGGILTTGTCAIFFGLldkveghYPFIILSFVIRIVEALGN 120
Cdd:cd17370 30 GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSALAKPLLAL-------AGSWQLVLLLRILERLGK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 121 AAFLTASFAIIAKEFPD-NVATTFASLETFFGLGLIVGPTVGGAL--YQVGGYTTPFAVLG--SALFLAAVMTAFVLPTH 195
Cdd:cd17370 103 GIRTPPRDALLADATPPsGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLLAAipALLALLILLFVVKEYPR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 196 DNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSM-SIGFLQAtlepHLRQFNLSPVVLGLMFIINGGTYAITAPAWGWLC 274
Cdd:cd17370 183 PPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNfSFAFLIL----RAQELGLSAALIPLLYALFNLVYALAAYPAGRLS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 275 DKYSKPKVATVigcVLVMVGFCLVGPAPFIPgttiIWLTILGLVIHGLGMSAQ------LVASFTDALRISISYgfpnnl 348
Cdd:cd17370 259 DRIGRKKLLIL---GYLSLALAYLGFALGSS----LWLLLLGFILWGLYMGAQesieraAVADLVPAELRGTAY------ 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1000763646 349 etyglisGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIV 399
Cdd:cd17370 326 -------GLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
42-404 |
4.17e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 55.31 E-value: 4.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 42 GASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPK-LLFNGGILttgtCAIFFGLLdkveGHYPFIILSF-VIRIVEALG 119
Cdd:cd17353 34 GWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRkAILIGGIL----FGLGFILS----AFAISLPLLFlGYGVLGGIG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 120 NAAFLTASFAIIAKEFPDN--VATTFASLEtfFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFVL----- 192
Cdd:cd17353 106 AGIGYITPVSTAVKWFPDKrgLATGIVIAG--FGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdppk 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 193 ----PTHDNDEQDTQDSGGFM---KVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFN-LSPVVLGLMFIINGGTYA 264
Cdd:cd17353 184 gwvpPGVDPLANNAENSPRDYtprEMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAgLDAGIAALAVSILSIFNG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 265 ITAPAWGWLCDKYSKPKVATVIgcvLVMVGFCLVGpAPFIPGTTIIWLTILGLVIHGLGMSAQLVASFTdalriSISYGF 344
Cdd:cd17353 264 GGRPFWGWLSDKIGRKNTLSIA---FLIQGVAMFL-LPFIGSVAVLFVLGVALIGFCYGGGFALFPALT-----ADFFGT 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 345 PNNLETYGLisgLWTStFALGAFIGPSIAGILLDTIGFrNASMFIVLLHLIVGIVATLFL 404
Cdd:cd17353 335 KNAGTNYGL---LYTA-KGVGGLIGPIIAAYVLYTGGY-NAAFIIAAALSLVALALALLL 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-193 |
5.35e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 5.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 38 AEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLG--PKLLFNGGILTTGTCAIFFGLLDkveGHYPFIILSFVIriv 115
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLP---SPALAIALLFLA--- 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000763646 116 eALGNAAFLTASFAIIAKEFPDN-VATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAFVLP 193
Cdd:COG2271 282 -GFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
32-400 |
8.61e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.15 E-value: 8.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 32 PFYPHEAEKKGASATEYGLVFG-------IFEFVVFIISPIYGQHlnrlgpKLLFNGGILTTGTCAIFFGLLDKVEGHYP 104
Cdd:cd17490 17 PFLSPYAESLGASLSMIGIILGaygisqmLLRIPLGILSDRIGKR------KLFIIIGLLFTVLASLIMILFPSPWGLLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 105 FIILSfvirivealGNAAFLTASFAII-AKEFPDNVATTFASLETFF-GLGLIVGPTVGGALYQVGGYTTPFAVLGSALF 182
Cdd:cd17490 91 ARFLS---------GIAAATWVSFTVLyASYFPPDEAAKAMGLINLVnNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 183 LAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAA-SIIVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIINGG 261
Cdd:cd17490 162 LGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFSLlAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 262 TYAITAPAWGWLCDKYSKPKVATVIGcvLVMVGFCLVgPAPFIPGTTIIWLTilgLVIHGLGMSaqLVASFTDALRISIS 341
Cdd:cd17490 242 PNALASLLSGTLFYKKLGERNTIIIG--FLLLGAYCF-LIPFAPNLTLLYLL---QALNGFGTG--ILFPLLMSLSIEGV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1000763646 342 ygfpnNLETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVA 400
Cdd:cd17490 314 -----PAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
3-187 |
3.39e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 3 RQFTKRQWLTLIVISIADFANAicvslQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGG 82
Cdd:cd17370 196 KKLPKAFWLYLLAVALFALGNF-----SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 83 ILTTGTCAIFFGLLDKVeghyPFIILSFvirIVEALGNAAFLTASFAIIAKEFPDNV-ATTFASLETFFGLGLIVGPTVG 161
Cdd:cd17370 271 YLSLALAYLGFALGSSL----WLLLLGF---ILWGLYMGAQESIERAAVADLVPAELrGTAYGLFNTVVGIGWLLASLIA 343
|
170 180
....*....|....*....|....*.
gi 1000763646 162 GALYQVGGYTTPFAVLGSALFLAAVM 187
Cdd:cd17370 344 GYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
31-403 |
4.13e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 52.20 E-value: 4.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 31 APFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLG-PKLLFNGGILTTgtcAIFFGLLDKVEGHYPfiiLS 109
Cdd:cd17335 17 LPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAA---VLFFLSLFFVAQIFW---LL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 110 FVIRIVEALGNAAFLTASFAI---IAKEFPDNVattfaSLETFFG-LGLIVGPTVGGAL---YQVGGYTTPFAVLGSALF 182
Cdd:cd17335 91 LLLVILGAFFSAPVVPLVDSItlqYLGEERERY-----GKQRLWGsIGFGIAALLVGILidrSSTYKNYTIAFYVFAVLM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 183 LAAVMTAFVLPTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIINGGT 262
Cdd:cd17335 166 LLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 263 YAITAPAWGWLCDKYSKPKvatvigcVLVMVGFCLVGPAPFIPGTTIIWLTILGLVIHGLGMSAQLVASFTDALRIsisy 342
Cdd:cd17335 246 EIPFFFFSSRLIQRFGHVG-------LLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA---- 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1000763646 343 gFPNNLET------YGLISGLwtsTFALGAFIGpsiaGILLDTIGFRNASMFIVLLHLIVGIVATLF 403
Cdd:cd17335 315 -APPGLRAtaqgllQGLYFGL---GGGLGSLIG----GYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
243-404 |
9.15e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.07 E-value: 9.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 243 RQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSkPKVATVIGCVLVMVGFCLVGPAPFipgttiIWLTILGL-VIHG 321
Cdd:cd17353 31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGG-PRKAILIGGILFGLGFILSAFAIS------LPLLFLGYgVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 322 LGMSAQLVASFTDALRIsisygFPNNLetyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVAT 401
Cdd:cd17353 104 IGAGIGYITPVSTAVKW-----FPDKR---GLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGA 175
|
...
gi 1000763646 402 LFL 404
Cdd:cd17353 176 FLI 178
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
21-403 |
2.02e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 49.95 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 21 FANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIFFGLLDKVe 100
Cdd:cd17393 9 FINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSV- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 101 ghYPFIILSFVIRIVEALGNAAFLTASFAIIAKEFPdnvaTTFASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSA 180
Cdd:cd17393 88 --PALALALFLFGAANGALDVAMNAQGVAVERAYGR----PIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 181 LFLAAVMTA--FVLPTH---DNDEQDTQDSGGFM---KVLRIPGVMVAAASIIVTSM---SIGFLQATLEphlrqfnLSP 249
Cdd:cd17393 162 LLLLAALVAirALLPGTgeaAEDRPDGAGKPGFLlpnRLLLLLGLLALAAALAEGAAadwSALYLRDVLG-------ASA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 250 VVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFCLVGPAPfipgttIIWLTILGLVIHGLGMSAQLV 329
Cdd:cd17393 235 ALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVL-RAGALLAALGLLLALLAP------SVWVALAGFALMGLGLSVVVP 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000763646 330 ASFTDALRIsisygfPNNLETYGLISGLWTSTfaLGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLF 403
Cdd:cd17393 308 LAFSAAGAL------PGLAAGIAVARVATLGY--LGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
27-378 |
4.43e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 48.76 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 27 VSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFnggILTTGTCAIFFGLLdkveGHYPFI 106
Cdd:cd17390 12 VSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVL---LICLLLTALGYVLL----GFSTSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 107 ILSFVIRIVEALGNAAfLTASFAIIAKEFPDN-VATTFASLETFFGLGLIVGPTVGGALYQV-GGYTTPfAVLGSALFLA 184
Cdd:cd17390 85 ALLFLSRIPLGIFKHT-QSLCKAYLSDLVSEQeRSRVLGRFNAASSLGFILGPVVGGHLAETdGGFYYV-ALLCSAIFIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 185 AVMTAFVLPTHDNDeqdtqdsggfmkVLRIPGVMVAAASIIVTSMSIGFLQatlephlrQFNLSPVVLGLMFIINGGTYA 264
Cdd:cd17390 163 NAGLVWFLLSKLWD------------LLLVRFLMGFSVLLFRSNFSLYLEE--------RFDLSPKTIGYLISYSGVLGA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 265 ITAPAWGWLCDKYSKPKVATVIGCVLVMVgFCLVGPApfipGTTIIWLTILGLVIHGLGmSAQLVASFTDalrISISYGF 344
Cdd:cd17390 223 LSGFLVGRILKLYKNNEYLLLLHSFILLA-LSLLGLA----LAPSIWLLVLCLTPLSIS-SAVLRTCSTS---LLLSRGK 293
|
330 340 350
....*....|....*....|....*....|....
gi 1000763646 345 PNNLetyGLISGLWTSTFALGAFIGPSIAGILLD 378
Cdd:cd17390 294 SKER---GTLLGVGQSVTSLARILAPLLSGLLQE 324
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
33-404 |
4.85e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 33 FYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLlfnggILTTGTCAIFFGL-LDKVEGHYPFIILSFv 111
Cdd:cd17352 25 LFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRP-----VAIAGGLLAALGLlLSSFATSLWQLYLTY- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 112 iRIVEALGNAAFLTASFAIIAKEFPDN--VATTFASLETffGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTA 189
Cdd:cd17352 99 -GVLGGLGLGLIYSPAIVIVGQYFEKKrgLATGIAVAGS--GVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 190 fvlpthdndeqdtqdsggFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIINGGTYAITAPA 269
Cdd:cd17352 176 ------------------LLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 270 WGWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPFIPGTTIIWLTILGLVIHG-LGMSAQLVASFTDALRISISYGFPNNL 348
Cdd:cd17352 238 LGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSySSLTPVILADLVGLEKLSNAYGLVLLF 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1000763646 349 EtyglisglwtstfALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:cd17352 318 Q-------------GLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
21-402 |
5.85e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.47 E-value: 5.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 21 FANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKllfnGGILTTGTCAIFFGLLDKVE 100
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRR----RTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 101 GHYPFIILSFVIrivEALGNAAFLTASFAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGAL-YQVGGYTTPFAVLGS 179
Cdd:cd17333 82 PSIYLFVVLMFL---AGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 180 ALFLAAVMTAFVL-----PTHDNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSPVVLGL 254
Cdd:cd17333 159 IYLLLAILILLTLfpelpSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 255 MFI-INGGTYAITAPAWGWLCDKYsKPKVATVIGCVLVMVGFCLVGPAPFipGTTIIWLTILGlvihGLGMSAQLVASFT 333
Cdd:cd17333 239 YLLsGFWVGITIGRLLGGPISRRI-KPHTLLVLSGSGALLGLLILLLAPT--LVVGLVATALL----GLFMAALFPTILS 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000763646 334 DALRIsISYGFPNNLeTYGLISGlwtstfALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATL 402
Cdd:cd17333 312 LGISN-LPYAKGKGT-SVLLAAG------SIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
110-395 |
5.93e-06 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 48.46 E-value: 5.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 110 FVIRIVEALGNAAFLTASFAIIAKEFPDNVATTFA---SLeTFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAV 186
Cdd:cd17383 87 FFARSLQGVGSAFADTAGLAMIADRFTEEAERSKAlgiAL-AFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 187 MTAFVLPTHDN--DEQDTQDSGGFMKVLRI-PGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSPVVLGLMFIINGGT 262
Cdd:cd17383 166 LLLLVMKPVRRetRANMPEPVGTPIHRLLMdPYIAVCAGALTMANVSLAFLEPTIANWMKDtMNASEWQMGLVWLPAFFP 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 263 YAITAPAWGWLCDKYskPKVATVIGCV-LVMVGFCLVgpapFIPGTTIIWLTILGLVIHGLGM----SAQL--VASFTDA 335
Cdd:cd17383 246 HVLGVYLTVKLAAKY--PHYQWLMAAVgLAIEGASCF----IVPFCTNFGVLIIPLCGICFGIalvdTALLptLGFLVDV 319
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 336 LRISIsygfpnnletYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLI 395
Cdd:cd17383 320 RHVSV----------YGSVYAIADISYSLAYALGPIVAGQIVHSIGFTQLNIGIGLANLL 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
225-404 |
1.18e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 225 IVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSkPKVATVIGCVLVMVGFCLVGPAPfi 304
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLFAFAP-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 305 pgttIIWLTILGLVIHGLGMSAQLVASFTDALRISisygfpnNLETYGLISGLWTSTFALGAFIGPSIAGILLD--TIGF 382
Cdd:cd06174 83 ----SFWLLLLGRFLLGLGSGLIDPAVLALIADLF-------PERERGRALGLLQAFGSVGGILGPLLGGILASslGFGW 151
|
170 180
....*....|....*....|..
gi 1000763646 383 RNASMFIVLLHLIVGIVATLFL 404
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVV 173
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
13-298 |
1.91e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.84 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 13 LIVISIADFANAICVSLQAPFYPHEAEKKGASATE-----YGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTG 87
Cdd:PRK09874 16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 88 TCAIFFGLLDKVeghYPFIILSFVIRIVealgnAAFLTASFAIIAKEFPDNVAT-TFASLETFFGLGLIVGPTVGGALYQ 166
Cdd:PRK09874 96 IVMVLMGLAQNI---WQFLILRALLGLL-----GGFVPNANALIATQVPRNKSGwALGTLSTGGVSGALLGPLAGGLLAD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 167 VGGYTTPFAVLGSALFLAAVMTAFVL-----PTHDNDEQDTQDSGGFMKVLRIpgvmvaAASIIVTSMSIGFLQATLEPH 241
Cdd:PRK09874 168 SYGLRPVFFITASVLFLCFLVTLFCIrenfqPVSKKEMLHMREVVTSLKNPKL------VLSLFVTTLIIQVATGSIAPI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1000763646 242 LRQF------NLSPVVL--GLMFIINGGTYAITAPAWGWLCDKYSKPK--VATVIGCVLVMVGFCLV 298
Cdd:PRK09874 242 LTLYvrelagNVSNIAFisGMIASVPGVAALLSAPRLGKLGDRIGPEKilITALIFSVLLLIPMSFV 308
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
244-433 |
2.24e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 244 QFNLSPVVLGLMFIINGGTYAITAPAWGWLCD----KYSKPKVATVIGCVLVMVGFCLVGPAPFIPGTTIIWLTILGLVI 319
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 320 HGLGMSAQLVASFTDALRISISYgfpnnlETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIV 399
Cdd:COG2211 120 LGLAYTLVNIPYSALGAELTPDY------EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLG 193
|
170 180 190
....*....|....*....|....*....|....
gi 1000763646 400 ATLFLTCCNSGPKPYTEVGSHEDIRASLSCSIRN 433
Cdd:COG2211 194 LLAFLLTFFGTKERPVPEEEKVSLKESLKALLKN 227
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
111-379 |
2.73e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 111 VIRIVEALGNAAFlTASFAIIAKEFPDN-VATTFASLETFFGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTA 189
Cdd:cd17504 89 AGRALQGIGGAVF-PLAFALVREEFPPErVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVP 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 190 FVLpthdndeqdtqdsggfMKVLRIPGVMVAAASIIVTSMSIGFLQATLePHLRQ------FNLSPVVLGLMFIINGGTY 263
Cdd:cd17504 168 LID----------------LRLLRRRNVLLANITALLAGFGMFMVFQLL-PQLLQlptptgFGLGITEAGLLLLPGALVM 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 264 AITAPAWGWLCDKYSkPKVATVIGCVLVMVGFCLVGpapFIPGTtiIWLTILGLVIHGLGMSAqLVASFTDALRISISYG 343
Cdd:cd17504 231 LIAGPLAGRLIARVG-PRRVLLIGLVISAVGLLLLA---LLHSS--LWALVVALLLIGIGLGL-AFASLPNIVVESVPPD 303
|
250 260 270
....*....|....*....|....*....|....*.
gi 1000763646 344 FPnnletyGLISGLWTSTFALGAFIGPSIAGILLDT 379
Cdd:cd17504 304 RT------GIATGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
213-404 |
2.81e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.96 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 213 RIPGVMVAAASIIVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKpKVATVIGCVLVM 292
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR-KRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 293 VGFCLVGPAPfipgtTIIWLtILGLVIHGLGMSAQLVASFTdalriSISYGFPNnlETYGLISGLWTSTFALGAFIGPSI 372
Cdd:COG0477 91 LASLLCGLAP-----SPELL-IAARALQGIGAGGLMPGALA-----LIAELFPA--RERGRALGLWGAAIGLGLALGPLL 157
|
170 180 190
....*....|....*....|....*....|...
gi 1000763646 373 AGILLDTIGFRnaSMFIVLLHL-IVGIVATLFL 404
Cdd:COG0477 158 GGLLVAALGWR--WIFLINAPLgLLALVLRLRL 188
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-191 |
3.32e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 3.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 6 TKRQWLtLIVISIADFANAICVSLQAPFYPHEAekKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILT 85
Cdd:COG2223 204 DPRFWL-LSLLYFGTFGSFIGFSSWLPPYLVDQ--FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 86 TGTCAIFFGLLdkVEGHYPFIILSFVIRIVEALGNAAFltasFAIIAKEFP-DNVATTFASLETFFGLGLIVGPTVGGAL 164
Cdd:COG2223 281 MALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAV----FALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
170 180
....*....|....*....|....*...
gi 1000763646 165 YQV-GGYTTPFAVLGSALFLAAVMTAFV 191
Cdd:COG2223 355 LDAtGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
45-370 |
5.04e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 45.70 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 45 ATEYGLVFGIFEFVVFIISPIYGQHLNRLG--PKLLfnggiLTTGTCAIFFGLLdkveGHYPFIILSFVIRIVEALGNAA 122
Cdd:cd17388 37 ATHYGVLLALYALMQFIFAPILGALSDRFGrrPVLL-----LSLAGAALDYLLM----AFAPTLWWLYLGRIIAGITGAT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 123 FLTASFAIIAKEFPDNVATTFASLETFFGLGLIVGPTVGGALYQVgGYTTPFAVLGSALFLAAVMTAFVLP-TH------ 195
Cdd:cd17388 108 GAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLFVLPeSLpperrr 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 196 DNDEQDTQDSGGFMKVLRIPGVMVAAASIIVTSMsIGFLQATLEPHLRQ--FNLSPVVLGLMFIINGGTYA-ITAPAWGW 272
Cdd:cd17388 187 AFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQL-IGQVPATTWVLFTEdrFDWSPTMVGLSLAVFGLLHAlFQAFVTGP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 273 LCDKYSKpKVATVIGCVLVMVGFCLVGPApfipgtTIIWLTILGLVIHGLGMSAQlvasftDALRISISYGFPNNLEtyG 352
Cdd:cd17388 266 IAKRLGE-KRAILLGLAADALGFLLLAFA------TQGWMVFPILILLALGGIAG------PALQGLLSRQVPENEQ--G 330
|
330
....*....|....*...
gi 1000763646 353 LISGLWTSTFALGAFIGP 370
Cdd:cd17388 331 ELQGVLTSLTSLTSIIGP 348
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
271-378 |
6.32e-05 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 45.18 E-value: 6.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 271 GWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPFIPgttIIWLTILGLVIHGLGMSAQLVASFTDALRISISygfpnnlET 350
Cdd:cd06176 280 GFLLSRRLGKKRTAALGCLLSALGFLLLALAGLLG---NPWLFRPGVFLLGLGNGLFTVGALTLMMDLTGE-------GT 349
|
90 100
....*....|....*....|....*...
gi 1000763646 351 YGLISGLWTSTFALGAFIGPSIAGILLD 378
Cdd:cd06176 350 AGLFMGLWGAAQALARGLGTLLGGALRD 377
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
153-383 |
8.64e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 44.99 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 153 GLIVGPTVGGALYQVGgyTTPFAVLGSALFLAAVMTAFvLPTHDNDEQDTQD----------SGGFMKVLRIPGVMVAAA 222
Cdd:pfam13347 155 FPLVLILGGTGLERKG--YRIFALIGAVLMLLGVIITA-AGTKERVSMRSKEdtgqkeagslLDMLKEVFRNRAFLILLA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 223 SIIVTSMSIGFLqATLEPHLRQFnlspvVLGLMFIINGGTYA------ITAPAWGWLCDKYSKPKvATVIGCVLVMVGFc 296
Cdd:pfam13347 232 SFLLAALAMGVL-NGLLLYYFRY-----VLGNGFAASAFPLVftigalLGIPLWPPLAKRIGKKN-TYILGALITIAGF- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 297 lVGPAPFIPGTTIIWLTILGLVIHGLGMSAQLVASF-TDAlrisISYG-FPNNLETYGLISGLWTSTFALGAFIGPSIAG 374
Cdd:pfam13347 304 -ALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMlADV----VDYGeLRTGKRREGTFFAMWSFISKLATGVGLGVSG 378
|
....*....
gi 1000763646 375 ILLDTIGFR 383
Cdd:pfam13347 379 LLLSAFGYN 387
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
119-400 |
5.41e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.20 E-value: 5.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 119 GNAAFLTASFAIIAKEFPDNV-----ATTFASLETFFGLGLIVGPTVGGALyqvgGYTTPFAVLGSALFLAAVMTAFVLP 193
Cdd:cd17472 96 GSGAISSVVMALLADLTREENrtkamALIGASIGIAFAISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVP 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 194 THDNDEQDTQDSGGFMK-VLRIPGVMVAAASIIVTS--MSIGF--LQATLEPHLRQFNLSPVVLGLMFIINGGTYAITAp 268
Cdd:cd17472 172 DPPKIVQISEKEKKKLKkLLKNKRLLRLDFSIFILHfvLMAFFyiLPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFV- 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 269 awgWLCDKYSKPKVATVIGCVLVMVGFCLVGPAPfipgtTIIWLTILGLVIHGLGMSaqlvaSFTDALRISISYGFPNnl 348
Cdd:cd17472 251 ---IYAEKKGKMKQVFVSSILLIAVGFLLLLFAA-----TSLWLLIIGLIIFFIGFN-----LLEALLPSLVSKIAPK-- 315
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1000763646 349 ETYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVA 400
Cdd:cd17472 316 EYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVS 367
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
225-413 |
7.43e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 41.83 E-value: 7.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 225 IVTSMSIGFLQATLEPHLRQFNLSPVVLGLMFIInggtYAITA--PAWGWLCDKYSKPKVAT----VIGCVLVMVGFCLV 298
Cdd:cd17485 7 LAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLL----YLPWVlkFLWAPLVDRYGLPRLGRrrswLLPTQLGLALLLLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 299 GPapFIPGTTIIWLTILGLVIHGLGMSAQLVAsfTDALRISISYGfpnnlETYGLISGLWTSTFALGAFIGPSIAGILLD 378
Cdd:cd17485 83 LA--FLPPTTNLLAFLGLLFLLNLFSATQDIA--TDGLAVELLTP-----EERGLGNAAQVVGYKLGSLLGGGGLLWLYD 153
|
170 180 190
....*....|....*....|....*....|....*
gi 1000763646 379 TIGFRNASMFIVLLHLiVGIVATLFLTCCNSGPKP 413
Cdd:cd17485 154 LIGWQSLLLSLAALYL-LLLLPVLFLRELELPQQP 187
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
243-403 |
1.07e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 243 RQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVaTVIGCVLVMVGFCLVGPAPfipgtTIIWLtILGLVIHGL 322
Cdd:cd17321 24 RDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRV-FLIGLALFGLASLLCALAP-----SLAFL-IAARALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 323 G-------MSAQLVASFTDALRisisygfpnnletyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRnaSMFivLLHLI 395
Cdd:cd17321 97 GaaaimpaSLALIAATFPGERR--------------GRALGLWGAVVGIGAALGPLLGGLLLELFGWR--WIF--LINVP 158
|
....*...
gi 1000763646 396 VGIVATLF 403
Cdd:cd17321 159 IGLVALLL 166
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
253-404 |
1.09e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.10 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 253 GLMFIINGGTYAITAPAWGWLCDKYS-KPKV-ATVIGCVLVMVGFCLVgpapfipgTTIIWLTIL----GLVIHGLGMSA 326
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGrKPMLlRASLGMAIVIGLMAFV--------TNVWQLLILrllqGVFSGYVPNAT 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1000763646 327 QLVASFTdalrisisygfPNNLETYGLiSGLWTSTFAlGAFIGPSIAGILLDTIGFRNAsMFIVLLHLIVGIVATLFL 404
Cdd:cd17391 111 ALIASQT-----------PKEKSGWAL-GTLSTGVVA-GTLIGPLLGGFLADLFGIRNV-FFITGGLLFLAFLLTLFF 174
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
244-403 |
1.61e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.70 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 244 QFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYsKPKVATVIGCVLVMVGFCLVGPAPFIPGTTiIWLTILGLVIhgLG 323
Cdd:cd17341 235 RFGLPLVTAGILAALFPLAGALARPAGGWLSDRF-GGRRRLWWLFIVMTIGAALLSLSLPTSGTN-LVLFLALFVA--LG 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 324 MSAQLVASFTDALrisISYGFPNNLetyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLF 403
Cdd:cd17341 311 LGAGAGNGSVFRM---VPFIFRREL---GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
9-404 |
1.73e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.72 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 9 QWLTLIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGT 88
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 89 CAIFFGLLDKVeghYPFIILSFVIRIVEALG---NAAFLTASFAiiAKEFpdnvATTFASLETFFGLGLIVGPTVGGALY 165
Cdd:cd17312 81 ANIFMGFSTSL---WFFAVLWGLNGLFQSMGwppCVKLLGNWFS--KKER----GTVYGIWSTSHNFGGILAPILAASLA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 166 QVGGYTTPFAVLGSALFLAAVMTAFVLpthdndeqdtQDSGGFMKVLRIPGVMVAAASIIVTSMSIGFLQAtlephlrQF 245
Cdd:cd17312 152 SYYGWRAAFLVPGIVGLVVAIILFFFL----------RDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYE-------VK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 246 NLSPVVLGLMFIINGGTYAITAPAWGWLCDKY--SKPKVATVIGCVLVMVGFCLVGPAPFIPGTTIIWLTILGLVIHGLG 323
Cdd:cd17312 215 GYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 324 MSAQLVASftdalrisiSYGFPNNLEtyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVllhlIVGIVATLF 403
Cdd:cd17312 295 NLIGGAAA---------QDIGRKEAA--GTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLI----SAALLSVLL 359
|
.
gi 1000763646 404 L 404
Cdd:cd17312 360 L 360
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
6-191 |
2.59e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 6 TKRQWLTLIVISIADFANAICVSLQAPFyphEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNggILT 85
Cdd:cd17353 212 TPTFWLLWLMFFLNATAGLMLIGQAKPI---GQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS--IAF 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 86 TGTCAIFFGLLDKVEGHYPFIILSFVIriveALGNAAFLTASFAIIAKEF-PDNVATTFASLETFFGLGLIVGPTVGGAL 164
Cdd:cd17353 287 LIQGVAMFLLPFIGSVAVLFVLGVALI----GFCYGGGFALFPALTADFFgTKNAGTNYGLLYTAKGVGGLIGPIIAAYV 362
|
170 180
....*....|....*....|....*..
gi 1000763646 165 YQVGGYTTPFAVLGSALFLAAVMTAFV 191
Cdd:cd17353 363 LYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
211-403 |
2.86e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.82 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 211 VLRIPGVMVAAASI--IVTSMSIGFLQATLephlrqfNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVaTVIGC 288
Cdd:cd17369 230 LLLAIGLRLAENVLfyLFTTFALSYATQTL-------GVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPV-YLAGA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 289 VLVMVgfcLVGPAPFIPGTTIIWLTILGL-----VIHGLGMSAQ---LVASFTDALR---ISISYGFpnnletyglisgl 357
Cdd:cd17369 302 LLAAL---FAFPFFWLLDTGSTWLIVLAAvvvlgVLHGMMYGPQaafLAELFPTRVRytgASLGYQL------------- 365
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1000763646 358 wtsTFALGAFIGPSIAGILLDTIGfrnaSMFIVLLHLIVGIVATLF 403
Cdd:cd17369 366 ---GAILGGGFAPLIATALVAATG----SWWPVALYLAALAVISLV 404
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
34-403 |
3.14e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 34 YPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTtgtcAIFFGLLDKVEGHYPFIILSfviR 113
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALAL----FTLGSLLCGLAPNLASLIIF---R 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 114 IVEALGNAAFLTASFAIIAKEFPDNV---ATTFASLETffGLGLIVGPTVGGALYQVGGYTTPFAVLGSALFLAAVMTAF 190
Cdd:cd17503 92 ILQGFGGGVLIPLAQTILLRIYPPEKrgaAMGLVGLVI--LLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 191 VLpthdndeqdtqdsggfMKVLRIPGVMVAAASIIVTSMSIGFLQATLEPHLRQ-FNLSPVVLGLMFIINGGTYAITAPA 269
Cdd:cd17503 170 LD----------------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 270 WGWLCDKYSKPKVatVIGCVLVMVGFCLvgPAPFIPGTTIIWLTILGLVIHGLGMSAQLVASFTDALRisisyGFPNNLe 349
Cdd:cd17503 234 VGRLLDKFGPRLL--LLAGLLLLALGTL--LLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALN-----SLPPEQ- 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1000763646 350 tYGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLF 403
Cdd:cd17503 304 -IGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQVQKQALII 356
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
245-404 |
3.49e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 245 FNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSkPKvATVIGCVLVMVGFCLVgpAPFIPGTTIIWltILGLVIhGLGM 324
Cdd:COG2270 269 LGFSTTELIVFGLLVQIVAALGALLFGRLDDRIG-PK-RVILVSLVIWIVVCLA--AYFLTTALAFW--ILGLLI-GLVM 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 325 SAQLVASFTDALRISisygfPNNLETYGLisGLWTSTFALGAFIGPSIAGILLDTIGFRNASMFIVLLHLIVGIVATLFL 404
Cdd:COG2270 342 GGIQALSRSLLARLI-----PPGREAEFF--GLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRV 414
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-158 |
7.39e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 7.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 13 LIVISIADFANAICVSLQAPFYPHEAEKKGASATEYGLVFGIFEFVVFIISPIYGQHLNRLGPKLLFNGGILTTGTCAIF 92
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1000763646 93 FGLLDKVEGHYPFIILSFVIriveALGNAAFLTASFAIIAKEFPDNVATTFASL-ETFFGLGLIVGP 158
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLL----GFGFGLVFPALNALVSDLAPKEERGTASGLyNTAGSLGGALGP 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
232-404 |
9.68e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 9.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 232 GFLQATLEPHLRQFNLSPVVLGLMFIINGGTYAITAPAWGWLCDKYSKPKVAtVIGCVLVMVGFCLVGpapFIPGttiIW 311
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLL-PLGPLLTGLGLSLLG---FAPN---YW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000763646 312 LTILGLVIHGLGMS------AQLVASFTDALRisisygfpnnletyGLISGLWTSTFALGAFIGPSIAGILLDTIGFRNA 385
Cdd:cd17478 86 LLLLLVALAGIGSAafhpegARLASQAAGGRR--------------GLAMSIFSVGGNLGFALGPLIAAALVALFGGLGL 151
|
170
....*....|....*....
gi 1000763646 386 SMFIVLLHLIVGIVATLFL 404
Cdd:cd17478 152 LILLIIPGLAVALLLLRLR 170
|
|
| |
