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Conserved domains on  [gi|974108816|ref|XP_015253501|]
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PREDICTED: kelch-like protein 11 [Cyprinodon variegatus]

Protein Classification

kelch-like protein( domain architecture ID 13605437)

kelch-like protein may act as a substrate adaptor for Cullin 3 ubiquitin ligases

Gene Ontology:  GO:0005515
PubMed:  17120193|10603472|23676014|15544948

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-174 1.44e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18241:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 135  Bit Score: 212.41  E-value: 1.44e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  34 FTCPAYCCQLSRRQNEQRKAGLFCDLTLVFSSRGASSgerhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWS 113
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGRE------FRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974108816 114 SAAGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18241   75 SEPGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 169-256 5.39e-50

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18451:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 88  Bit Score: 168.99  E-value: 5.39e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 974108816 249 ERERYFEE 256
Cdd:cd18451   81 ERERYFEE 88
PHA03098 super family cl33709
kelch-like protein; Provisional
 56-510 3.02e-37

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 146.45  E-value: 3.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRGASSGerhltlpAHRCVLSAASQYFELLLGGQFSESQtgrVELREwssaagpDPETVEAVIHFMYTGSV 135
Cdd:PHA03098   9 FCDESIIIVNGGGIIK-------VHKIILSSSSEYFKKMFKNNFKENE---INLNI-------DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPF 215
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 216 HLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERYFEELFKLVRLPQIPPTDLTRL-------------VRKEPLVA 282
Cdd:PHA03098 152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLkrwklrikkkkivFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 283 NSSVCQQLVVDALEYHAVCSESVKSGNLDPSTLY-------------MAAIHPRLGENM----DVIMVIGGVSEGGEYLS 345
Cdd:PHA03098 232 IYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNyitnysplseintIIDIHYVYCFGSvvlnNVIYFIGGMNKNNLSVN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 346 ECVGYFVAEDRWVNLPHIHNHLDGHAVAVAGGNVYVAGSMEPGFA-KMVERYNTSLNCWEDVSSLTTRKHSFGLTCVRDV 424
Cdd:PHA03098 312 SVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 425 LYGIGGHGNFSPGFKDVTVYKPEQDEWISLEPAPKILRDVKTVSVDDrYVYVMArtpeDIDHDDGLSTVTM--CYDTESL 502
Cdd:PHA03098 392 IYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG-KIYVIG----GISYIDNIKVYNIveSYNPVTN 466


                 ....*...
gi 974108816 503 RWQEVHSL 510
Cdd:PHA03098 467 KWTELSSL 474
Kelch smart00612
Kelch domain;
581-627 9.70e-07

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 9.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 974108816   581 VFVIGGWRNSgnldrQYRKEAYRYCAEKKRWTLLPPLPQPRCRAAAC 627
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-174 1.44e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 212.41  E-value: 1.44e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  34 FTCPAYCCQLSRRQNEQRKAGLFCDLTLVFSSRGASSgerhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWS 113
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGRE------FRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974108816 114 SAAGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18241   75 SEPGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 169-256 5.39e-50

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 168.99  E-value: 5.39e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 974108816 249 ERERYFEE 256
Cdd:cd18451   81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 56-510 3.02e-37

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 146.45  E-value: 3.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRGASSGerhltlpAHRCVLSAASQYFELLLGGQFSESQtgrVELREwssaagpDPETVEAVIHFMYTGSV 135
Cdd:PHA03098   9 FCDESIIIVNGGGIIK-------VHKIILSSSSEYFKKMFKNNFKENE---INLNI-------DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPF 215
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 216 HLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERYFEELFKLVRLPQIPPTDLTRL-------------VRKEPLVA 282
Cdd:PHA03098 152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLkrwklrikkkkivFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 283 NSSVCQQLVVDALEYHAVCSESVKSGNLDPSTLY-------------MAAIHPRLGENM----DVIMVIGGVSEGGEYLS 345
Cdd:PHA03098 232 IYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNyitnysplseintIIDIHYVYCFGSvvlnNVIYFIGGMNKNNLSVN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 346 ECVGYFVAEDRWVNLPHIHNHLDGHAVAVAGGNVYVAGSMEPGFA-KMVERYNTSLNCWEDVSSLTTRKHSFGLTCVRDV 424
Cdd:PHA03098 312 SVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 425 LYGIGGHGNFSPGFKDVTVYKPEQDEWISLEPAPKILRDVKTVSVDDrYVYVMArtpeDIDHDDGLSTVTM--CYDTESL 502
Cdd:PHA03098 392 IYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG-KIYVIG----GISYIDNIKVYNIveSYNPVTN 466


                 ....*...
gi 974108816 503 RWQEVHSL 510
Cdd:PHA03098 467 KWTELSSL 474
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 174-276 4.27e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 114.18  E-value: 4.27e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  174 CVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERY 253
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 974108816  254 FEELFKLVRLPQIPPTDLTRLVR 276
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 174-273 6.22e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 102.42  E-value: 6.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816   174 CVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERY 253
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 974108816   254 FEELFKLVRLPQIPPTDLTR 273
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 48-169 1.10e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.87  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816   48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVI 127
Cdd:pfam00651   2 NELREQGELCDVTLVVGDK---------EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD------VSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 974108816  128 HFMYTGSVrVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:pfam00651  67 EFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
357-627 5.45e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.60  E-value: 5.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 357 WVNLPHIHNHLDGHAVAVAGGNVYVAGSMEPGFA-KMVERYNTSLNCWEDVSSL-TTRKHSFGLTCVRDVLYGIGGHGNF 434
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 435 SPG---FKDVTVYKPEQDEWISLEPAPKIlRDVKTVSVDDRYVYVMARTpedidHDDGLSTVTMCYDTESLRWQEVHSLP 511
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTP-RGGATALLLDGKIYVVGGW-----DDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 512 lidnycifqmavsSSTFYHTASCCPKSyKV------TFETAQQKVSRtipeeiLDSLPSEVLGMEGAAicfLGEDVFVIG 585
Cdd:COG3055  157 -------------TPRDHLAAAVLPDG-KIlviggrNGSGFSNTWTT------LAPLPTARAGHAAAV---LGGKILVFG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 974108816 586 GwrnsgnlDRQYRKEAYRYCAEKKRWTLLPPLPQPRCRAAAC 627
Cdd:COG3055  214 G-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 58-169 7.57e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 84.66  E-value: 7.57e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816    58 DLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRV 137
Cdd:smart00225   1 DVTLVVGGK---------KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD------VSPEDFRALLNFLYTGKLDL 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 974108816   138 TNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
581-627 9.70e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 9.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 974108816   581 VFVIGGWRNSgnldrQYRKEAYRYCAEKKRWTLLPPLPQPRCRAAAC 627
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 571-618 2.83e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 2.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 974108816  571 GAAICFLGEDVFVIGGWRNSGNLDRqyrkeAYRYCAEKKRWTLLPPLP 618
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNS-----VEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 369-410 1.22e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 974108816  369 GHAVAVAGGNVYVA-GSMEPGFAKMVERYNTSLNCWEDVSSLT 410
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-174 1.44e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 212.41  E-value: 1.44e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  34 FTCPAYCCQLSRRQNEQRKAGLFCDLTLVFSSRGASSgerhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWS 113
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGRE------FRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974108816 114 SAAGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18241   75 SEPGPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 169-256 5.39e-50

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 168.99  E-value: 5.39e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 974108816 249 ERERYFEE 256
Cdd:cd18451   81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 56-510 3.02e-37

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 146.45  E-value: 3.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRGASSGerhltlpAHRCVLSAASQYFELLLGGQFSESQtgrVELREwssaagpDPETVEAVIHFMYTGSV 135
Cdd:PHA03098   9 FCDESIIIVNGGGIIK-------VHKIILSSSSEYFKKMFKNNFKENE---INLNI-------DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPF 215
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 216 HLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERYFEELFKLVRLPQIPPTDLTRL-------------VRKEPLVA 282
Cdd:PHA03098 152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLkrwklrikkkkivFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 283 NSSVCQQLVVDALEYHAVCSESVKSGNLDPSTLY-------------MAAIHPRLGENM----DVIMVIGGVSEGGEYLS 345
Cdd:PHA03098 232 IYSKKYNLNKILPRSSTFGSIIYIHITMSIFTYNyitnysplseintIIDIHYVYCFGSvvlnNVIYFIGGMNKNNLSVN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 346 ECVGYFVAEDRWVNLPHIHNHLDGHAVAVAGGNVYVAGSMEPGFA-KMVERYNTSLNCWEDVSSLTTRKHSFGLTCVRDV 424
Cdd:PHA03098 312 SVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 425 LYGIGGHGNFSPGFKDVTVYKPEQDEWISLEPAPKILRDVKTVSVDDrYVYVMArtpeDIDHDDGLSTVTM--CYDTESL 502
Cdd:PHA03098 392 IYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG-KIYVIG----GISYIDNIKVYNIveSYNPVTN 466


                 ....*...
gi 974108816 503 RWQEVHSL 510
Cdd:PHA03098 467 KWTELSSL 474
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 174-276 4.27e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 114.18  E-value: 4.27e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  174 CVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERY 253
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 974108816  254 FEELFKLVRLPQIPPTDLTRLVR 276
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 174-273 6.22e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 102.42  E-value: 6.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816   174 CVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERY 253
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 974108816   254 FEELFKLVRLPQIPPTDLTR 273
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-175 2.17e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 101.80  E-value: 2.17e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  45 RRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVE 124
Cdd:cd18237   10 GVMNNMRKQKTLCDVILIVEGR---------EIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD------AEPDIIE 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974108816 125 AVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18237   75 LLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 48-169 1.10e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.87  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816   48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVI 127
Cdd:pfam00651   2 NELREQGELCDVTLVVGDK---------EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD------VSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 974108816  128 HFMYTGSVrVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:pfam00651  67 EFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-152 7.53e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 95.70  E-value: 7.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVIHFMYTGSV 135
Cdd:cd18186    1 LCDVTLVVGGR---------EFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVS------PEAFEALLDYIYTGEL 65

                         90
                 ....*....|....*..
gi 974108816 136 RVTNANVHDVLELADRF 152
Cdd:cd18186   66 ELSEENVEELLAAADKL 82
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 169-298 1.95e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 96.31  E-value: 1.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELaLEAAEK-IRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDL-MQAAEVfSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDK 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974108816 248 EERERYFEELFKLVRLPQIPPTDLTRLVRKEPLVANSSVCQQLVVDALEYH 298
Cdd:cd18452   80 EEREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH 130
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 169-298 7.81e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 91.63  E-value: 7.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 974108816 249 ERERYFEELFKLVRLPQIPPTDLTRLVRKEPLVANSSVCQQLVVDALEYH 298
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 169-298 6.01e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 88.97  E-value: 6.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 974108816 249 ERERYFEELFKLVRLPQIPPTDLTRLVRKEPLVANSSVCQQLVVDALEYH 298
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-174 8.99e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 88.27  E-value: 8.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVI 127
Cdd:cd18242   13 NSLRKSNTLCDVTLRVEGK---------EFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLT------ASTMEILL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18242   78 DFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-177 4.52e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 86.80  E-value: 4.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  28 PEEAEEftcPAYCCQLSRRQNEQRKAGLFCDLTLVFSSRGASSGERHLtLPAHRCVLSAASQYFELLLGGQFSESQTGRV 107
Cdd:cd18273    1 PEELED---AAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPGSGRL-FPCNRNVLAAASPYFKSMFTGGLYESKQETV 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 108 ELRewssaaGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18273   77 TIH------DVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
357-627 5.45e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.60  E-value: 5.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 357 WVNLPHIHNHLDGHAVAVAGGNVYVAGSMEPGFA-KMVERYNTSLNCWEDVSSL-TTRKHSFGLTCVRDVLYGIGGHGNF 434
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 435 SPG---FKDVTVYKPEQDEWISLEPAPKIlRDVKTVSVDDRYVYVMARTpedidHDDGLSTVTMCYDTESLRWQEVHSLP 511
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTP-RGGATALLLDGKIYVVGGW-----DDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 512 lidnycifqmavsSSTFYHTASCCPKSyKV------TFETAQQKVSRtipeeiLDSLPSEVLGMEGAAicfLGEDVFVIG 585
Cdd:COG3055  157 -------------TPRDHLAAAVLPDG-KIlviggrNGSGFSNTWTT------LAPLPTARAGHAAAV---LGGKILVFG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 974108816 586 GwrnsgnlDRQYRKEAYRYCAEKKRWTLLPPLPQPRCRAAAC 627
Cdd:COG3055  214 G-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 58-169 7.57e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 84.66  E-value: 7.57e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816    58 DLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRV 137
Cdd:smart00225   1 DVTLVVGGK---------KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD------VSPEDFRALLNFLYTGKLDL 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 974108816   138 TNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-174 1.54e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 84.82  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaa 116
Cdd:cd18250    2 PAHALHLLRGLSELRAERKFFDVTLCAGGR---------EFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVS--- 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 974108816 117 gpdPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18250   70 ---AEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-175 2.06e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 84.38  E-value: 2.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrewssaAGPDPETVEAVI 127
Cdd:cd18256   12 NKLRGQHEFCDVQLQVGME---------LFSVHRLVLAASSPYFAALFAGGMSESSKDVVQI------HGVEPDIFHILL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18256   77 DFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-177 5.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 83.46  E-value: 5.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLvfssrgaSSGERHLtlPAHRCVLSAASQY-FELLLGGQFSESQTgRVELRewssaaGPDPETVEAV 126
Cdd:cd18306   10 NALRKNRQFCDVIL-------QVGGHEI--PAHRAVLACASPYlFELFSSDSDGESIL-TVKLD------GLDPDAVEVL 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974108816 127 IHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18306   74 VNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-174 1.71e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 81.60  E-value: 1.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVI 127
Cdd:cd18240    9 NELRLEGKLCDVVIRVNGV---------EFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVS------PEMMELII 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18240   74 EYAYTRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-169 3.20e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 80.93  E-value: 3.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVfssrgASSGErhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVI 127
Cdd:cd18235   13 NELRKQNLLCDVILV-----ADGVE----IPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQD------VDGKALLLLI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:cd18235   78 DYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-176 8.05e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 80.20  E-value: 8.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpetVEAVI 127
Cdd:cd18265   15 NAYRRSGTFTDVVLLVDGK---------DFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAA------MEVLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVA 176
Cdd:cd18265   80 DYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 169-264 2.22e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 77.73  E-value: 2.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPF-HLVRdWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18448    2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAqHLEK-LISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 974108816 248 EERERYFEELFKLVRLP 264
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 172-281 3.36e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 77.66  E-value: 3.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELaLEAAEK-IRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEER 250
Cdd:cd18445    4 SNCLGIRAFADLHSCTDL-LKYAQTyTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENR 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 974108816 251 ERYFEELFKLVRLPQIPPTDLTRLVRKEPLV 281
Cdd:cd18445   83 KEHLAELLEHVRLPLLSPEYLVQRVEEEELI 113
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-177 5.87e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 77.83  E-value: 5.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  77 LPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQ 156
Cdd:cd18269   39 FPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLED------VDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPS 112

                         90       100
                 ....*....|....*....|.
gi 974108816 157 LKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18269  113 IFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-175 7.17e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 76.64  E-value: 7.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  57 CDLTLVfssrgasSGERhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVIHFMYTGSVR 136
Cdd:cd18234    2 CDVILI-------AGDR--RIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLK------DVDPDALWTLVQYCYTGRLE 66

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974108816 137 VTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18234   67 LKEDNVESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-165 8.05e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 76.61  E-value: 8.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  43 LSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrewsSAAGPDPET 122
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGE---------EIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKI----ELEGISVEV 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 974108816 123 VEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18245   68 MEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 172-268 1.14e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 75.83  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18444    5 SNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERK 84

                         90
                 ....*....|....*..
gi 974108816 252 RYFEELFKLVRLPQIPP 268
Cdd:cd18444   85 KHLAKLLALIRLPLLTP 101
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-177 2.51e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 76.03  E-value: 2.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  77 LPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQ 156
Cdd:cd18340   39 FPCHRLVLAACSPYFRAMFLSDLEESKKREIVLED------VDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPS 112

                         90       100
                 ....*....|....*....|.
gi 974108816 157 LKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18340  113 IFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-176 3.72e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 75.02  E-value: 3.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFssrgassGERHLtlPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWssaagpDPETVEAVI 127
Cdd:cd18238    7 HQFYENGELCDVTLKV-------GEKSI--HCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI------DEEAVELLV 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVA 176
Cdd:cd18238   72 DFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-168 5.52e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 74.24  E-value: 5.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFssrgassGERHLTlpAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVI 127
Cdd:cd18247   11 EEIRRQGKLCDVTLKV-------GDQKFS--AHRIVLAATIPYFHAMFTHDMVESKQDEITMQ------GIEPSALEALI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKK 168
Cdd:cd18247   76 NFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-163 7.01e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 74.06  E-value: 7.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  42 QLSRRQNeqrkAGLFCDLTLvfssrgASSGErhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRV-ELREWSSAagpdp 120
Cdd:cd18293    5 QLHRQQN----SGVFCDVLL------QAEGE---SVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAH----- 66

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 974108816 121 eTVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCAD 163
Cdd:cd18293   67 -TLLKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLCLE 108
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-177 8.86e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 75.02  E-value: 8.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  34 FTCPAYCCQLSRRQNEQRKAGLFCDLTLvfssrgaSSGERhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREws 113
Cdd:cd18267   18 FHKSSYADSVLTHLNLLRQQRLFTDVLL-------HAGNR--SFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHD-- 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 974108816 114 saaGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18267   87 ---SIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-165 1.31e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 73.05  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  55 LFCDLTLVFssrgassGERHLTLPAHRCVLSAASQYFELLLGGQF-SESQTGRVELrewssaAGPDPETVEAVIHFMYTG 133
Cdd:cd18294   13 EFSDVKFLV-------GPERQEIFAHKCILAARCEVFRAMFLTGPqKESTQSPLVL------SDIEPEVFRAVLEFIYTN 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 974108816 134 SVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18294   80 CVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 79-161 2.27e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 71.99  E-value: 2.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELREWssaagpDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLK 158
Cdd:cd18314   20 AHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDV------EPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLE 93


                 ...
gi 974108816 159 NFC 161
Cdd:cd18314   94 KLC 96
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-169 5.86e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 71.64  E-value: 5.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  45 RRQNEQRKAGLFCDLTLVfssrgassgERHLTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVE 124
Cdd:cd18338   10 KVMNELRSQNLLCDVTIV---------AEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE------VDGWTLK 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 974108816 125 AVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:cd18338   75 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 173-272 7.11e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 70.80  E-value: 7.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 173 NCVAVHSLAHMYSLNELaLEAAEK-IRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18457    5 NCLGIRQFAETMMCSSL-VDAANKyIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENRE 83

                         90       100
                 ....*....|....*....|.
gi 974108816 252 RYFEELFKLVRLPQIPPTDLT 272
Cdd:cd18457   84 EYLPELLSKVRLPLLRPQFLT 104
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-169 7.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 71.29  E-value: 7.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaa 116
Cdd:cd18339    2 PAHMKKAFKVMNELRSKQLLCDVTIVAED---------VEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD----- 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 974108816 117 gPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:cd18339   68 -VDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-177 8.14e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 71.36  E-value: 8.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  41 CQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDP 120
Cdd:cd18268    8 SELLRQLNSLRQERILTDVILCTGDK---------EIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLK------GIDS 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 974108816 121 ETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18268   73 DVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-165 1.25e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 70.73  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  77 LPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpetVEAVIHFMYTGSVRVTN---ANVHDVLELADRFL 153
Cdd:cd18287   34 FPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEA------FKALLKYIYTGRLTLTDlkeDVLLDVLGLAHQYG 107

                         90
                 ....*....|..
gi 974108816 154 LGQLKNFCADFL 165
Cdd:cd18287  108 FEELEAAISDYL 119
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-177 1.48e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 70.84  E-value: 1.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  42 QLSRRQNEQRKAGLFCDLTLVFSsrgassgerHLTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPE 121
Cdd:cd18336    5 QTFRKMENYLQHKQLCDVLLIAG---------NLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKME------GVDPD 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816 122 TVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18336   70 ALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-177 2.24e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 70.26  E-value: 2.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLG 155
Cdd:cd18341   38 SLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDN------VDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIP 111

                         90       100
                 ....*....|....*....|..
gi 974108816 156 QLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18341  112 SVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-175 2.41e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 70.24  E-value: 2.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSV 135
Cdd:cd18259   32 LSDVTLLVGGR---------EFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD------VDPAVMESLIDFAYTGKL 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18259   97 TINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-175 7.58e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 68.88  E-value: 7.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaaGPDPETVEAVI 127
Cdd:cd18254   14 NTLRKQCMFTDVTLWAGNR---------SFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHD-----SLHPEVLELLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18254   80 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-165 8.13e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 68.72  E-value: 8.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVfsSRGassgerhLTLPAHRCVLSAASQYFELLLGGQFSESQTGRVelrewssAA 116
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTIK--TRG-------LEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA-------GG 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 974108816 117 GPD--------PETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18327   70 GQDvceldfvgPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-175 8.35e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 68.71  E-value: 8.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLG 155
Cdd:cd18271   35 TIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLS------PKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVS 108

                         90       100
                 ....*....|....*....|
gi 974108816 156 QLKNFCADFLVKKLSLSNCV 175
Cdd:cd18271  109 LLSKACSDFLIKSIDLTNCL 128
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-175 1.18e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 67.93  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  54 GLFCDLTLVfssrgASSGErhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrewssaAGPDPETVEAVIHFMYTG 133
Cdd:cd18252   19 GLFTDITLQ-----CASGQ---IFHCHKAALAACSSYFKVMFTADMKEKSNNVIKL------SGIDHDILEALVNYVYTS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 134 SVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18252   85 QICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-169 1.55e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 67.79  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRGASSgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVI 127
Cdd:cd18248   13 NELRLSQQLCDVTLKVKYQDPKE-----EFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIE------GVHPCVMSRLI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:cd18248   82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-174 2.00e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 67.17  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVI 127
Cdd:cd18253   10 NEFRDSRLFTDVIICVEGR---------EFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN------GILAEAMDCFL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18253   75 QYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-181 2.28e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 67.61  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrewssaAGPDPETVEAVI 127
Cdd:cd18266   17 NEQRQRGLFCDVVLVADEQ---------RVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVEL------VGASYIGLKAVI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAVHSLA 181
Cdd:cd18266   82 DFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 6.06e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 65.73  E-value: 6.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrEWSSAagpdpETVEAVI 127
Cdd:cd18326   17 NEQRTQGLLCDVVILVEGR---------EFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEI-DFVSA-----EALTALL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18326   82 DFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-169 7.01e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 65.64  E-value: 7.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  42 QLSRRQNEQRKAGLFCDLTLvfssrgaSSGERHLTlpAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpe 121
Cdd:cd18257    4 QLLQGLNLLRQHHELCDVVL-------RVGDVKIH--AHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETA----- 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 974108816 122 tVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:cd18257   70 -LQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 170-257 7.87e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 64.65  E-value: 7.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 170 SLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEE 249
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80


                 ....*...
gi 974108816 250 RERYFEEL 257
Cdd:cd18455   81 RKVHLKDL 88
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 172-257 1.68e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 63.47  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTL-PFHLV----RDwlldsEITVDSELELFEAIVKWVHQN 246
Cdd:cd18458    5 SNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLsPCQLValisRD-----ELNVRCESEVYNAVIRWVKYD 79

                         90
                 ....*....|.
gi 974108816 247 PEERERYFEEL 257
Cdd:cd18458   80 EENRRQYLEAL 90
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-174 1.87e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 64.34  E-value: 1.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVfssrgaSSGERhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwSSAAGpdpetVEAVI 127
Cdd:cd18255   10 NALRAKGQLLDVTLI------ADGQR---FQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKG-VSAKG-----LKHIL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18255   75 DFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 173-268 2.79e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 63.64  E-value: 2.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 173 NCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERER 252
Cdd:cd18446    5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLP 84

                         90
                 ....*....|....*.
gi 974108816 253 YFEELFKLVRLPQIPP 268
Cdd:cd18446   85 LLPRVLENVRLPLLDP 100
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 169-268 2.82e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 63.22  E-value: 2.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEItVDSELELFEAIVKWVHQNPE 248
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 974108816 249 ERERYFEELFKLVRLPQIPP 268
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 3.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 63.73  E-value: 3.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVI 127
Cdd:cd18198   17 NEQRTQGLLCDVVILVQGR---------EYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVS------PEALTALL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18198   82 EFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 77-169 3.69e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 63.47  E-value: 3.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  77 LPAHRCVLSAASQYFELLLGGQFSESQTGR-----VELREWSsaagpdPETVEAVIHFMYTGSVRVTNANVHDVLELADR 151
Cdd:cd18296   29 FPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVS------PEVFAIVLYYIYTDDTDLPPENAYDVLYVADM 102

                         90
                 ....*....|....*...
gi 974108816 152 FLLGQLKNFCADFLVKKL 169
Cdd:cd18296  103 YLLPGLKRLCGTVLAQSL 120
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 169-247 7.16e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 61.47  E-value: 7.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVI-RNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAkDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-175 7.28e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 63.07  E-value: 7.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTG-RVELrewsSAAGPDPETVEAV 126
Cdd:cd18258    9 NQQRRAKEFTDLKIIVEGK---------EFEVHQNVLASCSLYFKDLIKRSSRDSGGGeKLEL----TMSNINADVLELL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 974108816 127 IHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18258   76 LEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-174 7.54e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 62.90  E-value: 7.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVfssrgasSGERHLTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpetVEAVI 127
Cdd:cd18239   15 DQLRGEGLLCDVTLV-------PGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIG------LKNII 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18239   82 DFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 169-264 8.92e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 61.80  E-value: 8.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFytlpFHLVRDWL---LDS-EITVDSELELFEAIVKWVH 244
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEF----LHLTKDQLisiLNSdDLNVEKEEHVYESIIHWFE 76

                         90       100
                 ....*....|....*....|.
gi 974108816 245 QNPEERERYFEELF-KLVRLP 264
Cdd:cd18483   77 HEQSKREMHLPEIFaKCIRMP 97
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-173 9.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 62.29  E-value: 9.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELrewssaagPDP--ETVEAVIHFMYTGSVRVTNANVHDVLEL---ADRFL 153
Cdd:cd18297   26 AHKIVLVTASDRFKSMLSSGSTEAQTPVIEI--------PDIryDIFQLMMQYLYTGGVESLDVAQDDALELlraASFFQ 97

                         90       100
                 ....*....|....*....|
gi 974108816 154 LGQLKNFCADFLVKKLSLSN 173
Cdd:cd18297   98 LDGLKRHCEILLSQQIDLDN 117
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 169-264 1.28e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 61.50  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*.
gi 974108816 249 ERERYFEELFKLVRLP 264
Cdd:cd18467   81 ERQKYLAQLLHCVRLP 96
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 169-266 1.29e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 61.35  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*...
gi 974108816 249 ERERYFEELFKLVRLPQI 266
Cdd:cd18460   81 HRQHFWPELLQHVRLPFV 98
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 168-268 1.36e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 61.47  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 168 KLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|.
gi 974108816 248 EERERYFEELFKLVRLPQIPP 268
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPP 101
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 169-267 1.61e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 60.93  E-value: 1.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTL-PFHLVRDWLLDSeITVDSELELFEAIVKWVHQNP 247
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLsPDELIAIISSDS-LNVEKEEDVFEAVMKWVGKDQ 79

                         90       100
                 ....*....|....*....|
gi 974108816 248 EERERYFEELFKLVRLPQIP 267
Cdd:cd18516   80 EERTKALPVLLESIRFRLMP 99
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 76-184 1.82e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 61.51  E-value: 1.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVIHFMYTGSVRV-TNANVHDVLELADRFLL 154
Cdd:cd18286   28 TFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVS------HAAVSFVLLFIYGGVLDLpDDVNLGELLSLADMYGL 101

                         90       100       110
                 ....*....|....*....|....*....|
gi 974108816 155 GQLKNfcadflvkklslsncVAVHSLAHMY 184
Cdd:cd18286  102 DGLKD---------------VVAYTLRRDY 116
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-175 1.99e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 61.70  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWssaagpDPETVEAVI 127
Cdd:cd18249   15 NLLRKHRELCDVVLVVGAK---------KIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDI------DERAMELLI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18249   80 DFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 169-268 2.78e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 60.81  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|
gi 974108816 249 ERERYFEELFKLVRLPQIPP 268
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPP 101
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-164 3.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 60.71  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLggqfsESQTGRVELrEWSSAA 116
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDG---------VDFKAHKAVLAACSEYFRMLF-----VDQKDVVHL-DISNAA 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 974108816 117 GpdpetVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADF 164
Cdd:cd18206   68 G-----LGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 170-243 5.23e-11

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 58.96  E-value: 5.23e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 974108816 170 SLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWV 243
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWL 74
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-177 5.35e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 60.74  E-value: 5.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  54 GLFCDLTLVFssrgassgERHlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVIHFMYTG 133
Cdd:cd18244   28 GLLLDVTLVI--------EDH-QFQAHKALLATQSDYFRIMFTADMRERDQDKIHLK------GLTATGFSHVLQFMYYG 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 974108816 134 SVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18244   93 TIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-170 6.35e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 60.35  E-value: 6.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  38 AYCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESqtgrvelREWSSAAG 117
Cdd:cd18201    3 SYCYQLLQELNEQRKKGILCDVNIVVSGK---------VFRAHKNILVAGSRFFKTLYCFTNKES-------CDQTTVTH 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816 118 PDPETVEA---VIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLS 170
Cdd:cd18201   67 LDVVAVQGfsvILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 168-264 6.62e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 59.37  E-value: 6.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 168 KLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*..
gi 974108816 248 EERERYFEELFKLVRLP 264
Cdd:cd18459   81 QERRPHLPQVLQHVRLP 97
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-164 8.62e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 59.61  E-value: 8.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  54 GLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFE-LLLGGQFSESQTGRVELREwssaagpDPETV---EAVIHF 129
Cdd:cd18292   15 EELSDIVLRVGGK---------VFHAHRLILAKSSDVFRvMLSNDWWSESKQSEIELVE-------DPECAavfEKFLRY 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 974108816 130 MYTGSVRVTNANVHDVLELADRFLLGQLKNFCADF 164
Cdd:cd18292   79 LYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-177 9.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 59.67  E-value: 9.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  42 QLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPE 121
Cdd:cd18335    5 QTFRKMESYLKQQQLCDVILIAGNR---------KIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKME------GIDPN 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816 122 TVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18335   70 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-173 1.27e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 59.59  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVfssrgasSGERHLtlPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpetVEAVI 127
Cdd:cd18261   20 NQQRNDGILCDITLV-------AEEQKF--HAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLG------LKQAL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18261   85 DFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 172-267 1.56e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 58.61  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18469    6 TNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARA 85

                         90
                 ....*....|....*.
gi 974108816 252 RYFEELFKLVRLPQIP 267
Cdd:cd18469   86 AHLPELLSLVHLSLLT 101
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-175 1.92e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 59.09  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  78 PAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQL 157
Cdd:cd18236   37 SCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIK------GVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRM 110

                         90
                 ....*....|....*...
gi 974108816 158 KNFCADFLVKKLSLSNCV 175
Cdd:cd18236  111 VDACASFLTEALHPENCV 128
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 168-268 1.92e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 58.15  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 168 KLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|.
gi 974108816 248 EERERYFEELFKLVRLPQIPP 268
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAP 101
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-177 2.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 58.85  E-value: 2.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrewssaAGPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLG 155
Cdd:cd18274   34 TFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI------VGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIP 107

                         90       100
                 ....*....|....*....|..
gi 974108816 156 QLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18274  108 SLQDQCAQFMISRLDPQNSIGV 129
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 169-247 2.21e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 57.13  E-value: 2.21e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 169-250 2.77e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 56.95  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 974108816 249 ER 250
Cdd:cd18480   81 AR 82
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-172 3.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 57.62  E-value: 3.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  46 RQNEQRkagLF----CDLTLVFssrgassGERHLTLPAHRCVLSAASQYFELLlggqFSES-QTGRVELrewsSAAGPDP 120
Cdd:cd18231    3 RLNEQR---LFqpdlCDVDIVL-------VRQRSTFPAHKGVLAAYSQFFHSL----FTQNkQLQRVEL----SLEALTS 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 974108816 121 ETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADfLVKKLSLS 172
Cdd:cd18231   65 QGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQE-LIDSRSLS 115
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 76-169 4.03e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 57.25  E-value: 4.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTGRVELrewssaAGPDPETVEAVIHFMYTGSVRVT-NANVHDVLELADRFLL 154
Cdd:cd18300   20 TIPAHKALLVARCDVMAAMFGGNFRESSAKEVEL------PGVSKETFLALLEYLYTDQAPILeDGDCVGLIVLANRLCL 93

                         90
                 ....*....|....*
gi 974108816 155 GQLKNFCADFLVKKL 169
Cdd:cd18300   94 PRLVALCEQYIVKEL 108
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-175 4.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 58.09  E-value: 4.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  55 LFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGS 134
Cdd:cd18270   25 LLTDIVLIVEGT---------EFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN------VDAATLQIIITYAYTGN 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 974108816 135 VRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18270   90 LAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-175 5.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 57.33  E-value: 5.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  55 LFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQtgrvelreWSSAagpDPETVEAVIHFMYTGS 134
Cdd:cd18303   17 LYSDITIKLADK---------SIPAHKFVLAARSEKWSNENLASTNELD--------LSDI---SYEVVLALLRWLYTDE 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 974108816 135 VRVTNANVH--DVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18303   77 LDLTLDDEFllELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 169-271 5.58e-10

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 56.85  E-value: 5.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFytlpFHLVRDWLLDSeITVDS----ELELFEAIVKWVH 244
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGF----LTLSKSALKEL-LSRDSfcapEVDIFNAVRRWCE 75

                         90       100
                 ....*....|....*....|....*..
gi 974108816 245 QNPEERERyFEELFKLVRLPQIPPTDL 271
Cdd:cd14822   76 HNPDSKED-AKEILEAVRLPLMSLTEL 101
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-169 6.67e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 57.73  E-value: 6.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWssaagpDPETVEAVI 127
Cdd:cd18246   31 NRMRQRGLLCDIVLHVGTK---------EIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI------DPQALEQLV 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKL 169
Cdd:cd18246   96 QYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 170-222 7.37e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 54.97  E-value: 7.37e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 974108816 170 SLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWL 222
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELL 53
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 172-271 9.49e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 56.27  E-value: 9.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18468    3 SNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRK 82

                         90       100
                 ....*....|....*....|
gi 974108816 252 RYFEELFKLVRLPQIPPTDL 271
Cdd:cd18468   83 QHIAELLAVVRLPFIHPSYL 102
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 169-246 1.01e-09

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 55.43  E-value: 1.01e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQN 246
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 169-264 1.28e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 55.78  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*.
gi 974108816 249 ERERYFEELFKLVRLP 264
Cdd:cd18456   81 GRRQHVPRLMKCVRLP 96
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-177 1.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 56.22  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVfssrgasSGERHLtlPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVIHFMYTGSV 135
Cdd:cd18337   23 LCDVVLV-------AGDRRI--PAHRLVLSSVSDYFAAMFTNDVREAKQEEIKME------GVEPNALWALVQYAYTGRL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18337   88 ELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
331-476 2.58e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 58.63  E-value: 2.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 331 IMVIGGVSEGGEYLSECVgYFVAEDRWVNLPHIHNHLDGHAVAVA-GGNVYVAGsmepGFakmveRYNTSLNCWEDVSSL 409
Cdd:COG3055  124 IYVVGGWDDGGNVAWVEV-YDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIG----GR-----NGSGFSNTWTTLAPL 193

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 974108816 410 TTRKHSFGLTCVRDVLYGIGGHGNFspgFKDVTVYKPEQDEWISLEPAPKILRDVKTVSVDDRyVYV 476
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGK-VYV 256
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 169-264 2.59e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 54.74  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPe 248
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED- 79

                         90
                 ....*....|....*.
gi 974108816 249 ERERYFEELFKLVRLP 264
Cdd:cd18449   80 DRMQFAAKLMENIRFP 95
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-172 2.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 55.45  E-value: 2.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAA 116
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGK---------IFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQ 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816 117 GpdpetVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLS 172
Cdd:cd18230   73 G-----FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
329-445 3.79e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 58.24  E-value: 3.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 329 DVIMVIGGVSEGGEYlsecvgyfvaeDRWVNLPHIHNHLDGHAVAVAGGNVYVAGSmEPGFAKMVERYNTSLNCWEDVSS 408
Cdd:COG3055  170 GKILVIGGRNGSGFS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGG-ESGFSDEVEAYDPATNTWTALGE 237

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 974108816 409 LTTRKHSFGLTCVRDVLYGIGGH---GNFSPGFKDVTVYK 445
Cdd:COG3055  238 LPTPRHGHAAVLTDGKVYVIGGEtkpGVRTPLVTSAEVYD 277
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-165 4.18e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 54.55  E-value: 4.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  39 YCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESqtGRvelrewSSAAGP 118
Cdd:cd18330    1 YYTKLLGELNEQRKRDFFCDCSIIVEGR---------IFKAHRNILFANSGYFRALLIHYIQDS--GR------HSTASL 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 974108816 119 DPETVEA---VIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18330   64 DIVTSEAfsiILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-165 5.41e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 54.57  E-value: 5.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  39 YCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTgrVELREWSSAAGP 118
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVEGK---------EFRAHRAVLAACSEYFLQALVGQTENDLV--VSLPEEVTARGF 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 119 DPetveaVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18278   83 GP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 169-267 5.56e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 54.08  E-value: 5.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*....
gi 974108816 249 ERERYFEELFKLVRLPQIP 267
Cdd:cd18477   81 NRQKALPTVFESIRFRLLP 99
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-165 6.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 54.13  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  39 YCCQLSRRQNEQRKAGLFCDLTLVFssrgassgeRHLTLPAHRCVLSAASQYFELLLggQFSESQTGRVELREWSSAAGp 118
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVV---------KGVCFKAHKNVLAAFSQYFRSLF--QNSSSQKNDVFHLDIKNVGG- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 974108816 119 dpetVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18233   69 ----IGQILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 169-267 6.37e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 53.62  E-value: 6.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*....
gi 974108816 249 ERERYFEELFKLVRLPQIP 267
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLMP 99
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 7.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 54.12  E-value: 7.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRGASSgerhltlpaHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVI 127
Cdd:cd18328   17 NEQRHDGLLCDVVLIVQDQEYRT---------HRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVT------PEALSAIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18328   82 EFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 181-243 7.29e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 52.58  E-value: 7.29e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 974108816 181 AHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWV 243
Cdd:cd18493   12 AKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 56-173 7.72e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 53.91  E-value: 7.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVfssrgASSGErhlTLPAHRCVLSAASQYFELLLGGQFSESQtgrvelrewSSAAGPDP---ETVEAVIHFMYT 132
Cdd:cd18302    5 LYDVTIV-----SEDGK---EFPCHKCVLVARLEYFHSMLSSSWIEAS---------SCSALTMPipsDILEIILDYLYT 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 974108816 133 GSVR-VTNAN----VHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18302   68 DEASaVKESQnvefLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 7.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 54.06  E-value: 7.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLggqfseSQTGRvELREWSSAAGP--DPETVEA 125
Cdd:cd18329   13 DEQRKQELFCDCSILVEGQ---------VFKAHRNVLFASSGYFKMLL------SQNAK-ETGQPTVATFDvfSPDTFTI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 974108816 126 VIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18329   77 ILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
PHA02713 PHA02713
hypothetical protein; Provisional
 77-510 1.01e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 58.48  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  77 LPAHRCVLSAASQYFELLLGG-QFSESQTGRVELREWssaagpDPETVEAVIHFMYtgSVRVTNANVHDVLELADRFLLG 155
Cdd:PHA02713  38 IKAHKTILAAGSKYFRTLFTTpMIIRDLVTRVNLQMF------DKDAVKNIVQYLY--NRHISSMNVIDVLKCADYLLID 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 156 QLKNFCADFLVKKLSLSNCVAV-HSLAHMYSLnELALEAAEKIRRNFHRVIRNEEFYTLPFHLvrdwLLDSEITVDSELE 234
Cdd:PHA02713 110 DLVTDCESYIKDYTNHDTCIYMyHRLYEMSHI-PIVKYIKRMLMSNIPTLITTDAFKKTVFEI----LFDIISTNDNVYL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 235 LFEA-----IVKWVHQNpeererYFEELFKLVRLPQIpptDLTRLVRKEPLV--ANSSV-----CQQLVVDaleyhavcs 302
Cdd:PHA02713 185 YREGykvtiLLKWLEYN------YITEEQLLCILSCI---DIQNLDKKSRLLlySNKTInmypsCIQFLLD--------- 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 303 eSVKSGNLDPSTLYMAAIHPRLGENMDVIMViggvseggeylsecvgYFVAEDRWVNLPHIHNHLDGHAVAVAGGNVYVA 382
Cdd:PHA02713 247 -NKQNRNIIPRQLCLVCHDTKYNVCNPCILV----------------YNINTMEYSVISTIPNHIINYASAIVDNEIIIA 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 383 GSM---EPGFAKmVERYNTSLNCWEDVSSLTTRKHSFGLTCVRDVLYGIGGHgNFSPGFKDVTVYKPEQDEWISLEPAPK 459
Cdd:PHA02713 310 GGYnfnNPSLNK-VYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ-NGTNVERTIECYTMGDDKWKMLPDMPI 387

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 974108816 460 ILRDVKtVSVDDRYVYVMARTPE-------------DIDHDDGLSTVTMCYDTESLRWQEVHSL 510
Cdd:PHA02713 388 ALSSYG-MCVLDQYIYIIGGRTEhidytsvhhmnsiDMEEDTHSSNKVIRYDTVNNIWETLPNF 450
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-175 1.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 53.66  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGgqfSESQTGRVELREWSsaagpdPETVEAVI 127
Cdd:cd18260   10 NRMRQERFLCDLTIATKTK---------SFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDIS------PLGLATVI 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCV 175
Cdd:cd18260   72 TYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 1.11e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 53.58  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSEsqTGRvelrewSSAAGPD---PETVE 124
Cdd:cd18199   10 NEQRKQDFFCDCSIIVEGR---------IFKAHRNVLFASSGYFRMLLSHYIQD--TGR------PSTASFDvfsSDAFS 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 974108816 125 AVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18199   73 IILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-154 1.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 53.50  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLlggqFSESQTGRVELrewssAAGPDPETVEAVI 127
Cdd:cd18290   19 NEQRLQGLYCDVSVVVKGH---------AFKAHRAVLAASSSYFRDL----FNSSRSAVVEL-----PAAVQPQSFQQIL 80

                         90       100
                 ....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRvtnanvhdvLELADRFLL 154
Cdd:cd18290   81 SFCYTGRLS---------MNVGDQFLL 98
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-173 1.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 53.47  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLK 158
Cdd:cd18343   35 AHKSILAARSPVFNAMFEHEMEESKKNRVEIND------VDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLK 108

                         90
                 ....*....|....*
gi 974108816 159 NFCADFLVKKLSLSN 173
Cdd:cd18343  109 VMCEEALCNNLSVEN 123
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 173-263 1.38e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 52.75  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 173 NCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERER 252
Cdd:cd18479    5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                         90
                 ....*....|.
gi 974108816 253 YFEELFKLVRL 263
Cdd:cd18479   85 YLSSVLSQIRI 95
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
329-511 1.80e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.32  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 329 DVIMVIGG---VSEGGEYLSECVGYFVAEDRWVNLPHIHNHLDGHAVAVAGGNVYVA-GSMEPGFAKMVERYNTSLNCWE 404
Cdd:COG3055   71 GKLYVFGGftgANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVgGWDDGGNVAWVEVYDPATGTWT 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 405 DVSSLTTRKHSFGLTCVRD-VLYGIGGhGNFSPGfkdvtvykpeQDEWISLEPAPkILRDVKTVSVDDRYVYVMARtped 483
Cdd:COG3055  151 QLAPLPTPRDHLAAAVLPDgKILVIGG-RNGSGF----------SNTWTTLAPLP-TARAGHAAAVLGGKILVFGG---- 214

                        170       180
                 ....*....|....*....|....*...
gi 974108816 484 idhDDGLSTVTMCYDTESLRWQEVHSLP 511
Cdd:COG3055  215 ---ESGFSDEVEAYDPATNTWTALGELP 239
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-173 2.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 52.53  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  41 CQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWssaagpDP 120
Cdd:cd18279    3 CRLAEDLGNLWENSRFTDCCLCVGGQ---------EFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDV------DP 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 974108816 121 ETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18279   68 EVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 56-152 2.66e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 51.40  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTgRVELREWSSaagpdpETVEAVIHFMYTGSV 135
Cdd:cd18315    1 LVDVTLACEGG---------SLKAHKLVLAAASPYFAALLKETPPDEHP-VIILPDVPY------SELKALLDFIYTGEV 64

                         90
                 ....*....|....*..
gi 974108816 136 RVTNANVHDVLELADRF 152
Cdd:cd18315   65 NVSQEQLESLLKLAELL 81
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 79-173 2.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 52.48  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELR--EWssaagpdpETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQ 156
Cdd:cd18352   27 AHRIALLASSDAFRAMFDGGYREKEARDIEIPniRW--------EVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEG 98

                         90
                 ....*....|....*..
gi 974108816 157 LKNFCADFLVKKLSLSN 173
Cdd:cd18352   99 LKRLCEYTIAQDLTLEN 115
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-149 2.95e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 52.17  E-value: 2.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFE--LLLGgqFSESQTGRVelrewssaagPDPETVEA 125
Cdd:cd18229   10 NAQRLGGHFCDVTVRIHDA---------SLRAHRCVLAAGSPFFHdkLLLG--HSEIEVPPV----------VPAQTVRQ 68

                         90       100
                 ....*....|....*....|....
gi 974108816 126 VIHFMYTGSVRVTNANVHDVLELA 149
Cdd:cd18229   69 LVEFMYSGSLVVAQSEALQILTAA 92
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 168-264 2.96e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 51.98  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 168 KLSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*..
gi 974108816 248 EERERYFEELFKLVRLP 264
Cdd:cd18447   81 PNRQPYMVDILAKVRFP 97
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 169-266 3.18e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 51.80  E-value: 3.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNElALEAAEK-IRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNp 247
Cdd:cd18470    1 INVENCMYVVNIAETYGLKN-TKEAAQKfIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD- 78

                         90
                 ....*....|....*....
gi 974108816 248 EERERYFEELFKLVRLPQI 266
Cdd:cd18470   79 QKRVKYAADLLSNIRFGTI 97
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-173 4.00e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 52.44  E-value: 4.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  42 QLSRRQNEQRKAGLFCDLTL--VFSSRGASSGERHLtlPAHRCVLSAASQYFELLLGGQFSeSQTGRVELrewssaagPD 119
Cdd:cd18281    3 QASKTTVKERFAFLFNNETLsdVHFIVGKGDNEQRI--PAHKFVLSIGSAVFDAMFNGGMA-TTSAEIEL--------PD 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816 120 --PETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18281   72 vePAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-173 4.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 52.37  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  55 LFCDLTLVFSS-RGASSGERHLTLPAHRCVLSAASQYFELLLGGQFSeSQTGRVELrewssaagPD--PETVEAVIHFMY 131
Cdd:cd18346   21 LLSDVRFVVGKgRPRGPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMA-TTSAEIEL--------PDvePAAFLALLRFLY 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 132 TGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18346   92 SDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-153 5.95e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 51.72  E-value: 5.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  49 EQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQFSESQTgrVELREWSSAagpdpETVEAVIH 128
Cdd:cd18212   16 EQRKKDFLCDITLIVEN---------VQFRAHKALLAASSEYFSMMFADEGEVGQS--IYMLEGMVA-----ETFGALLE 79

                         90       100
                 ....*....|....*....|....*
gi 974108816 129 FMYTGSVRVTNANVHDVLELAdRFL 153
Cdd:cd18212   80 FIYTGCLQVGEKSLEQILATA-QFL 103
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-165 9.67e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 51.01  E-value: 9.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  46 RQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTgrvelrewssAAGPDPETV-- 123
Cdd:cd18228    9 KLNSLRNEGHFCDVTIRVQDK---------IFRAHKVVLAACSDFFRSKLVGQASPRLV----------LVSPAGKCVld 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974108816 124 ---------EAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18228   70 lhhvtvtgfAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 173-243 1.26e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 49.31  E-value: 1.26e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974108816 173 NCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWV 243
Cdd:cd18463    6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWV 76
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 172-267 1.28e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 49.84  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18514    4 SNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83

                         90
                 ....*....|....*.
gi 974108816 252 RYFEELFKLVRLPQIP 267
Cdd:cd18514   84 DYLPELLRNVRLALLP 99
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-164 1.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 49.80  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRGASsgerhltlpAHRCVLSAASQYFELLLggqFSESQTGRVELREWSSAAGPDPETVEAVIHFMYTGSV 135
Cdd:cd18307    1 FCDVVISVDNHSFA---------AHRNVLAAVSPFVKSLI---SSNDMKATDELSITIDCDYLSPETVEQLLDYFYTGKI 68

                         90       100
                 ....*....|....*....|....*....
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADF 164
Cdd:cd18307   69 VISEKNVEDLLKGAKYFNIPRLKDHCVDF 97
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-152 1.54e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 49.20  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  69 SSGERhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRVTNANVHDVLEL 148
Cdd:cd01165    5 VEGEK---FHVNKELLAQSSEYFRALFRGGFRESGQAEINLRD------ISPEDFRALLEFLYGGKRDLDASNLLELLEA 75


                 ....
gi 974108816 149 ADRF 152
Cdd:cd01165   76 ANFL 79
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 172-267 1.56e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 49.59  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|....*.
gi 974108816 252 RYFEELFKLVRLPQIP 267
Cdd:cd18515   83 CYLSELLQTVRLALLP 98
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-149 2.19e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 49.76  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSesqtGRVELREWSSaagpdpETVEAVI 127
Cdd:cd18232   10 NKQREEGQYCDATLDVGGR---------VFKAHWSVLACCSHFFQSLYGDGTS----GSVVLPESFA------EVFGLLL 70

                         90       100
                 ....*....|....*....|..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELA 149
Cdd:cd18232   71 DFFYTGELALTRENRDRVLLAA 92
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-173 2.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 50.10  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLK 158
Cdd:cd18342   36 AHKAILAARSPVFSAMFEHEMEESKKNRVEIND------VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLK 109

                         90
                 ....*....|....*
gi 974108816 159 NFCADFLVKKLSLSN 173
Cdd:cd18342  110 VMCEDALCSNLSVEN 124
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 172-268 2.57e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 49.34  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERE 251
Cdd:cd18485    4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRV 83

                         90
                 ....*....|....*..
gi 974108816 252 RYFEELFKLVRLPQIPP 268
Cdd:cd18485   84 QHLVELLKQVRLELVSP 100
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-150 3.04e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 49.37  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  39 YCCQLSRRQNEQRKAGLFCDLTLVFssrgassgeRHLTLPAHRCVLSAASQYFelllGGQFSESQTGRVELrewssaagp 118
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVI---------GQFQFKAHRNVLAAFSEYF----GAQYKDTEDNIVFL--------- 58

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 974108816 119 DPETV-----EAVIHFMYTGSVRVTNANVHDVLELAD 150
Cdd:cd18217   59 DQSQVsadgfQKLLEFIYTGNLNLDSWNVAEIHQAAS 95
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-165 4.54e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 49.19  E-value: 4.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  38 AYCCQLSR-------RQNEQRK-AGLFCDLTLvfssrgaSSGERhlTLPAHRCVLSAASQYFELLLGGQFSESQTGR-VE 108
Cdd:cd18207    1 SYTYQVSQhsadmlhNLNQQRKsGGRFCDVLL-------RVGEE--SFPAHRAVLAACSEYFESVFSAQEGDGGTPReLE 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 974108816 109 LREWSSAAGPDpetveaVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18207   72 MHTISSKVFGD------ILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVI 122
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 169-243 4.57e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 47.77  E-value: 4.57e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWV 243
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 172-271 4.86e-07

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 48.63  E-value: 4.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 172 SNCVAVHSLAHMYSLNELaLEAAEK-IRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEER 250
Cdd:cd18466    4 ANCIGIFQFSEQIACHDL-LEFTENyIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                         90       100
                 ....*....|....*....|.
gi 974108816 251 ERYFEELFKLVRLPQIPPTDL 271
Cdd:cd18466   83 KKHVVEVLEPVRFPLLPPQRL 103
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-174 5.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 49.41  E-value: 5.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  36 CPAYCCQLSRRQNEQRKAGLFCDLTLVfssrgASSGErhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSA 115
Cdd:cd18264    8 SKSHGEAVLSQYQSLRAEGFLCDVVLE-----AEGNE----FPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 974108816 116 AgpdpetVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNC 174
Cdd:cd18264   79 G------LQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-173 6.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 48.69  E-value: 6.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREwssaagPDPETVEAVIHFMYTGSV 135
Cdd:cd18345   18 FSDVTLCVGGR---------EFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD------VDHEVMREMLRFIYTGKA 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 974108816 136 RVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18345   83 PNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 6.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 48.52  E-value: 6.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSsrgassGERhltLPAHRCVLSAASQYFELLLGGQFSESQTgrVELREWSSAAGPDPetveaVI 127
Cdd:cd18277   19 NDQRKKDVLCDVTILVE------GQR---FRAHRSVLAACSSYFHSRIVGQADAELN--ITLPEEVTVKGFEP-----LI 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18277   83 QFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-177 7.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 48.65  E-value: 7.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  78 PAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSaagpdpETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQL 157
Cdd:cd18276   34 PCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITA------ESVSIILNYMYSSDLHLTNSNVQGVATAAFFLQMEDI 107

                         90       100
                 ....*....|....*....|
gi 974108816 158 KNFCADFLVKKLSLSNCVAV 177
Cdd:cd18276  108 FSVCQKYMMDHMDASNCLGI 127
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-150 9.18e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.97  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  43 LSRRQNEQRKaGLFCDLTLVFSSrgassGERhltLPAHRCVLSAASQYFELLLGGQFSESQTGRV--ELrewssaagpDP 120
Cdd:cd18311    2 LQRLQNLFNK-TEYCDLTLQFRD-----NEQ---LKVHRLVLSACTDYFNVLEQTCEIVDDTLIMpnEL---------QA 63

                         90       100       110
                 ....*....|....*....|....*....|
gi 974108816 121 ETVEAVIHFMYTGSVRVTNANVHDVLELAD 150
Cdd:cd18311   64 DAVVPVINFMYTGQLEFEEKSYGKLLRTAK 93
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-173 9.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 48.41  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELREWssaagpDPETVEAVIHFMYTGsvRVTNANVH----DVLELADRFLL 154
Cdd:cd18344   37 AHKAILAARSPVFRAMFEHEMEERLKNPIEIHDL------DPQVFKEMMGFIYTG--KAPHLHSHsmacDVLAAADKYGL 108

                         90
                 ....*....|....*....
gi 974108816 155 GQLKNFCADFLVKKLSLSN 173
Cdd:cd18344  109 EGLKVLCEDALCRNLSVEN 127
Kelch smart00612
Kelch domain;
581-627 9.70e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 9.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 974108816   581 VFVIGGWRNSgnldrQYRKEAYRYCAEKKRWTLLPPLPQPRCRAAAC 627
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-149 1.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 47.75  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFE--LLLGgqFSEsqtgrVELREWSSAagpdpETVEA 125
Cdd:cd18208   17 NEQRNRGHFCDVTVRIHGS---------MLRAHRCVLAAGSPFFQdkLLLG--YSD-----IEIPSVVSV-----QSVQK 75

                         90       100
                 ....*....|....*....|....
gi 974108816 126 VIHFMYTGSVRVTNANVHDVLELA 149
Cdd:cd18208   76 LIDFMYSGVLRVSQSEALQILTAA 99
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 81-152 1.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 46.74  E-value: 1.13e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816  81 RCV---LSAASQYFELLLGGQFSESQTGRVELREwssaAGPDPETVEAVIHFMYTGSVRVTNA-NVHDVLELADRF 152
Cdd:cd18190   12 CCVrkkIASLSRPFKAMLYGNFRESTSDCIDFEE----NGISIEAMRAVIDFSVTGRLDLFSVeNVHEVLELASKF 83
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-177 1.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 47.97  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  54 GLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAagpdpeTVEAVIHFMYTG 133
Cdd:cd18272   30 GLFADVTISVEGK---------EFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSES------VFQLLVDYIYHG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 974108816 134 SVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVAV 177
Cdd:cd18272   95 TVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-149 1.71e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.51  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  33 EFtcPAYCCQLSRRQNEQRKAGLFCDLT-LVFSSRgassgerhltLPAHRCVLSAASQYFELllggqFSESQTGRVELRE 111
Cdd:cd18194    2 EF--PEHSRQLLQCLREQRSQGFLCDCTvLVGSAQ----------FPAHRAVLASCSMYFHL-----FYRDRLDKRDLVR 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 974108816 112 WSSaagpdpETVEA-----VIHFMYTGSVRVTNANVHDVLELA 149
Cdd:cd18194   65 LNS------DIVTApafglLLDFMYEGRLALRDLPVEDVLAAA 101
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-176 2.32e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 47.11  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  52 KAGLFCDLTLvfssrgASSGERhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagpdPETVEAVIHFMY 131
Cdd:cd18263    9 EKGVGCDVQL------EADGSI---FRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIP------AKDLRLLISFAY 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 974108816 132 TGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSNCVA 176
Cdd:cd18263   74 SGILHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-168 2.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 47.35  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFssrgassGERHLTlpAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAA 116
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVV-------GNRHFK--AHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSEVVTA 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 974108816 117 gpdpETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKK 168
Cdd:cd18196   73 ----EAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTR 120
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 200-267 2.68e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 46.34  E-value: 2.68e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 974108816 200 NFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERYFEELFKLVRLPQIP 267
Cdd:cd18464   31 NFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRLALLP 98
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 3.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 46.39  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFssrgassgeRHLTLPAHRCVLSAASQYFELLLGGQfsesqtGRVELREWSSAAGPDPETVEAVI 127
Cdd:cd18332   11 NELRKRDILTDVTLLV---------GGTPLRAHKAVLIACSGFFYSIFSGR------VGEGVSVLTLPSGLEARGFQLLL 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18332   76 DFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 169-263 4.03e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 45.88  E-value: 4.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90
                 ....*....|....*
gi 974108816 249 ERERYFEELFKLVRL 263
Cdd:cd18462   81 KRIECAYDLLSSIKL 95
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-148 4.22e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 46.02  E-value: 4.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTG-RVELREwssaagpdPETVEAV 126
Cdd:cd18209   10 NEERLKGQLCDVLLIVGDQ---------KFRAHKNVLAASSEYFQSLFTEKENESQSVfQLDFCE--------PDAFENV 72

                         90       100
                 ....*....|....*....|..
gi 974108816 127 IHFMYTGSVRVTNANVHDVLEL 148
Cdd:cd18209   73 LNYIYSSSLFVEKSSLAAVQEL 94
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 169-262 4.96e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 45.57  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHR-VIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNP 247
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 974108816 248 EERERYFEELFKLVR 262
Cdd:cd18482   81 KERAASAAEVLKCVR 95
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-138 5.41e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 46.18  E-value: 5.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLlggqFSESQTGRVELrewssAAGPDPETVEAVI 127
Cdd:cd18289   21 NEQRLMGLYCDVSIVVKGQ---------AFKAHRAVLAASSLYFRDL----FSGNSKSAFEL-----PATVPPACFQQIL 82

                         90
                 ....*....|.
gi 974108816 128 HFMYTGSVRVT 138
Cdd:cd18289   83 SFCYTGKLTMA 93
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-101 5.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 45.59  E-value: 5.70e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974108816  39 YCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLL--GGQFSE 101
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIVEDR---------KFRAHKNILSASSTYFHQLFsvAGQVVE 59
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-116 6.11e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 45.19  E-value: 6.11e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 974108816  75 LTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAA 116
Cdd:cd18191   12 TQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGA 53
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-137 6.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 45.55  E-value: 6.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSaagpdpETVEAVI 127
Cdd:cd18223   10 NEQRIQGILCDVTIVVED---------TKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKA------EVFAEIL 74

                         90
                 ....*....|
gi 974108816 128 HFMYTGSVRV 137
Cdd:cd18223   75 NFIYSSKVVV 84
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-137 8.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 45.65  E-value: 8.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  39 YCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGgqfSESQTGRVELREWSSAAGP 118
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDT---------KFRAHRSVLAASSPYFRELLS---SPLPLGAAAVAAAPGATQS 68

                         90       100
                 ....*....|....*....|....*....
gi 974108816 119 DPETVEA----------VIHFMYTGSVRV 137
Cdd:cd18195   69 PERVLELpgvkagvfsdVLNFIYSSRVAL 97
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 141-262 1.73e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 44.12  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 141 NVHDVLELADRFLLGQLKNFCADFLVKKLSlsncvavhslahmyslnelaleaaeKIRRNfhrviRNEEFYTLPFHLVRD 220
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLS-------------------------ELLKS-----HPEEVLALPYRLLRE 54

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 221 WLLDSEITVDSELELFEAIVKWVHQNPeeRERYFEELFKLVR 262
Cdd:cd18471   55 VLKSDRLTSLSEEQIWQLAVRWLEHNC--RYQYMDELLQYVR 94
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-165 2.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 44.06  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFElllggqfsesqtGRVELREWSSAA 116
Cdd:cd18210    2 PEITSSLLESLNQQRMEGKLCDISIHVQGR---------VFRAHRAVLAASSPYFH------------DQVLLKNMSSIS 60

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 974108816 117 GP---DPETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18210   61 LPgvmDPGAFESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-153 2.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 43.87  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQFSESQTgRVELREWSSaagpdpETVEAVI 127
Cdd:cd18204   10 NEQRLEGEFCDIAIVVED---------VKFRAHRCVLAACSTYFKKLFKKLEVDSSS-VIEIDFLRS------DIFEEVL 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 974108816 128 HFMYTGSVRVTNANVHDVLE----LADRFL 153
Cdd:cd18204   74 NYMYTAKISVKKEDVNLMMSsgqiLGIRFL 103
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-173 2.85e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 44.29  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  42 QLSRRQNEQRKAGLFCDLTLVFSSRGASSGERHLTLPAHRCVLSAASQYFELLLGGQFSESQTgRVELrewssaagPD-- 119
Cdd:cd18347    3 QATKPTVQERFAFLFNNEVLSDVHFLVGKGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTST-EIEL--------PDve 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 974108816 120 PETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18347   74 PAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 55-165 2.90e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 43.35  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  55 LFCDLTLVFssrgassGERHlTLPAHRCVLSAASQYFELLLGgqfseSQTgRVELREWSSaagpdPETVEAVIHFMYTGS 134
Cdd:cd18299   11 SCADVVFIL-------QGGV-RIFAHRIVLAAASSVFADLFL-----MMT-VVTLDSDIT-----PEAFRRVLEFLYTGV 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 974108816 135 VRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18299   72 LDENEDDLKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-168 3.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 43.87  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFssrgassGERHLTlpAHRCVLSAASQYFELllggqFSESQTGRVELREWSSAA 116
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLV-------GEAQFR--AHRAVLASCSMYFHL-----FYRDQLDKRDIVHLNSDI 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 974108816 117 GPDPeTVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKK 168
Cdd:cd18325   70 VTAP-AFSLLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDK 120
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-161 3.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 43.47  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  70 SGErhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELRewssaaGPDPETVEAVIHFMYTGSV-RVTNANVHDVLEL 148
Cdd:cd18280   22 DGE---KFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIE------DVEPPVFKALLHFIYKDELpDDVEPAGSDSSSL 92

                         90       100
                 ....*....|....*....|....
gi 974108816 149 -----------ADRFLLGQLKNFC 161
Cdd:cd18280   93 dttmaqhllaaADRYALERLRLLC 116
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-161 4.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 43.30  E-value: 4.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFssrgasSGERHltlPAHRCVLSAASQYF-ELLLGGQFSESQTGRVELREWSSAagpdpeTVEAV 126
Cdd:cd18202   11 NQQRLNNQFCDVTLLI------EGEEY---KAHKSVLAANSEYFrELFIEKGAVSSHEAVVDLSGFCKS------SFLPL 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 974108816 127 IHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFC 161
Cdd:cd18202   76 LEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-166 5.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 43.27  E-value: 5.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  51 RKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpetVEAVIHFM 130
Cdd:cd18251   18 RDSGILFDVVLVVEGK---------PIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNA------MCKILDFI 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 974108816 131 YTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLV 166
Cdd:cd18251   83 YTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLM 118
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 76-158 6.13e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 43.01  E-value: 6.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSAAgpdpetVEAVIHFMYTGSVRVTNANVHDVLELADRFLLG 155
Cdd:cd18295   30 SFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDA------FRALLQYLYTGRLEIHVDDVEDCKRLAKQCRLE 103


                 ...
gi 974108816 156 QLK 158
Cdd:cd18295  104 ELI 106
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 173-252 6.20e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 42.44  E-value: 6.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 173 NCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWvHQNPEERER 252
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 56-152 6.39e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 41.93  E-value: 6.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FC-DLTLVFssRGAssgerhlTLPAHRCVLSAASQYF-ELLLGGQFSESQTgRVELRewssAAGPDPETVEAVIHFMYTG 133
Cdd:cd18283    1 YCtDVDLVF--QGT-------CFPVHRAILSARCPFFrDLLSSSPGYGAEI-PVDLP----TAGIDVPMFSALLRYLYTG 66

                         90       100
                 ....*....|....*....|..
gi 974108816 134 SVRV---TNANVHDVLELADRF 152
Cdd:cd18283   67 EFGSedsRSQNLDVLIQLSEEF 88
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-161 6.73e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 42.90  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  43 LSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGqfSESQTGRVELREWSSAAgpdpeT 122
Cdd:cd18224   13 LLKELNKCRLSETMCDVTIVVGNR---------SFAAHKAVLACAAGYFQKLFLS--TELDVARTYVVDFITPA-----N 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974108816 123 VEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFC 161
Cdd:cd18224   77 FEKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-170 7.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 43.49  E-value: 7.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFssrgassGERHLTlpAHRCVLSAASQYFELllggqFSESQTGRVELREWSSAAGPDPeTVEAVI 127
Cdd:cd18324   15 SEQRHQGFLCDCTVLV-------GDAQFR--AHRAVLASCSMYFHL-----FYKDQLDKRDIVHLNSDIVTAP-AFALLL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLS 170
Cdd:cd18324   80 EFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKAT 122
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-171 1.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 42.15  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  51 RKAGLFCDLTLVFSSRGASSgerhlTLPAHRCVLSAASQYF-ELLLGGQFSESQTGRVELREWSSAagpdpeTVEAVIHF 129
Cdd:cd18211   20 RLLGHLCDVTVQVEHQGSKE-----EFSAHKAVLAASSKYFkEVFLNEKISDGKNTNVMLNEIYTA------DFASFLEF 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974108816 130 MYTGSVRVTNANVHDVLELADRFLLGQLKNFCadFLVKKLSL 171
Cdd:cd18211   89 VYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC--FQLKKQML 128
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-165 1.65e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 40.91  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  57 CDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQFSESQTgrVELREWSSAAGPDPetveaVIHFMYTGSVR 136
Cdd:cd18955    2 CDVTIVVEDQ---------RFRAHRAVLAACSDYFLSRVVGQTDGDLV--ITLPEEVTVKGFEP-----LLQFAYTAKLL 65

                         90       100
                 ....*....|....*....|....*....
gi 974108816 137 VTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18955   66 LSKENVLEVCRCAEFLGVHNIEKACFDFL 94
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 173-257 1.78e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 40.64  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 173 NCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSeitVDSELELFEAIVKWVHQNPEEREr 252
Cdd:cd18481    5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEERE- 80


                 ....*
gi 974108816 253 YFEEL 257
Cdd:cd18481   81 GFSET 85
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 49-150 2.20e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.04  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  49 EQRKAGLFCDLTLvfSSRGASSGerhltlpAHRCVLSAASQYFElllgGQFSESQTGRVELrewssaaGP--DPETVEAV 126
Cdd:cd18262   11 RLREQRLLLDETV--SVGGRSYG-------VHSVILAAVSSLFR----ERLLGSNGPLPPL-------SLevTPVGWEAV 70

                         90       100
                 ....*....|....*....|....
gi 974108816 127 IHFMYTGSVRVTNANVHDVLELAD 150
Cdd:cd18262   71 LTFAYTGVLGRNPATVGDILVAAE 94
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 571-618 2.83e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 2.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 974108816  571 GAAICFLGEDVFVIGGWRNSGNLDRqyrkeAYRYCAEKKRWTLLPPLP 618
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNS-----VEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-165 3.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 41.08  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  33 EFtcPAYCCQLSRRQNEQRKAGLFCDLTLVFSSrgassgerHLtLPAHRCVLSAASQYF--ELLLggqfseSQTGRVELr 110
Cdd:cd18227    4 EF--PDFSSTILQKLNQQRQQGQLCDISVVVQG--------HL-FRAHKAVLAASSPYFcdQVLL------KNSRRIVL- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 974108816 111 ewssaagPD---PETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18227   66 -------PDvmnPRVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-164 5.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 40.24  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFELLLGGQfsesqtGRVELREWSSAAGPDPETVEAVI 127
Cdd:cd18215   11 NRLRSRDILTDVVLVVGRE---------QFRAHKTVLMACSGLFYSIFTDQ------LKNNVSVINLDPEIEPEGFRILL 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 974108816 128 HFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADF 164
Cdd:cd18215   76 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-165 6.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 39.84  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  48 NEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYF--ELLLGgqfsesQTGRVELrewssAAGPDPETVEA 125
Cdd:cd18200   10 NKHRLEGKFCDLSVHVQGR---------VFRAHKAVLAASSPYFhdKLLLN------DTNCLVL-----PSVIEAAAFEN 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 974108816 126 VIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFL 165
Cdd:cd18200   70 LLQLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-161 6.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 39.95  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYFE-LLLGGQFSESQTGRVelrewssa 115
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENA---------LFRAHKNILAASSMYFKsLVLHDNLINLDTDMV-------- 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 974108816 116 agpDPETVEAVIHFMYTGSVRVTNA----NVHDVLELADRFLLGQLKNFC 161
Cdd:cd18334   65 ---NPTVFRQILDFIYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALC 111
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 56-135 6.73e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 40.06  E-value: 6.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  56 FCDLTLVFSsrgassGERhltLPAHRCVLSAASQYFELLLGGQFSESQTGRVELREWSsaagPDPETVEAVIHFMYTGSV 135
Cdd:cd18309   20 FCDITLLLD------GHP---IPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMV----PSRQAFDSLLRYIYYGDV 86
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-168 6.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 40.18  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLT-LVFSSRgassgerhltLPAHRCVLSAASQYFELLLGGQFSESQTGrVELREwssa 115
Cdd:cd18956    4 PEHGGRLLGRLRQQRELGFLCDCTvLVGDAR----------FPAHRAVLAACSVYFHLFYRDRPAGGRDT-VRLNG---- 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 974108816 116 agpDPETVEA---VIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFCADFLVKK 168
Cdd:cd18956   69 ---DIVTAPAfgrLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLREK 121
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-150 7.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 39.81  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGqfseSQTGRVElrewssAA 116
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGT---------FHFRAHKLVLAASSLLFKSLLDS----TDTISID------AS 64

                         90       100       110
                 ....*....|....*....|....*....|....
gi 974108816 117 GPDPETVEAVIHFMYTGSVRVTNANVHDVLELAD 150
Cdd:cd18225   65 VVSPEEFALLLEMVYTGKLPPGKHNFTKIISVAD 98
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-161 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 39.15  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  43 LSRRQNEQRKAGLFCDLTLVFSSRgassgerhlTLPAHRCVLSAASQYfellLGGQFSESQTGRvelreWSSAAGPDPET 122
Cdd:cd18218    5 LLHLAARLRPAGALCDTLITVGSQ---------EFPAHSLVLAGASQQ----LGRQLTNPNPGQ-----WCLGEGISPST 66

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974108816 123 VEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLKNFC 161
Cdd:cd18218   67 FKQLLDFVYGESVEVQPGELRPLLEAARALEVESLEEAC 105
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 169-264 1.07e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 38.74  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNELALEAAEKIRRNFHRVIRNEEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPE 248
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                         90
                 ....*....|....*.
gi 974108816 249 ERERYfEELFKLVRLP 264
Cdd:cd18465   81 RRASA-SHVLCHIRFP 95
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 369-410 1.22e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 974108816  369 GHAVAVAGGNVYVA-GSMEPGFAKMVERYNTSLNCWEDVSSLT 410
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
578-627 1.35e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.88  E-value: 1.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 974108816  578 GEDVFVIGGWRNSGNldrQYRKEAYRYCAEKKRWTLLPPLPQPRCRAAAC 627
Cdd:pfam13415   1 GDKLYIFGGLGFDGQ---TRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 208-276 1.63e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 38.46  E-value: 1.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974108816 208 EEFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWVHQNPEERERYFEELFKLVRLPQIPPTDLTRLVR 276
Cdd:cd18453   31 EDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQ 99
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 76-136 1.67e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 39.21  E-value: 1.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTG--RVELREWSSAAGPDPETVEAVIHFMYTGSVR 136
Cdd:cd18310   30 PVPVHRCILAARSPFFRDIFASAKAEGANTkpKLELRELIPGGIVGYDAFMLVLSYLYSGRLR 92
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-169 2.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 38.15  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  76 TLPAHRCVLSAASQYFELLLGGQFSESQTgRVELrewssaagPD--PETVEAVIHFMYTGSVRVTNANVHDVLELADRFL 153
Cdd:cd18282   22 RIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEI--------PDvePAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYL 92

                         90
                 ....*....|....*.
gi 974108816 154 LGQLKNFCADFLVKKL 169
Cdd:cd18282   93 VPHLARACVQFLETSL 108
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-165 2.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.00  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  79 AHRCVLSAASQYFELLLGGQFSESQTGRVELREWSSaagpdpETVEAVIHFMYTGSVRVTNANVHDVLELADRFLLGQLK 158
Cdd:cd18298   26 VHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSY------PVYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERLK 99


                 ....*..
gi 974108816 159 NFCADFL 165
Cdd:cd18298  100 KLCEDII 106
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-135 2.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 38.26  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  37 PAYCCQLSRRQNEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQfsESQTGRVELrewsSAA 116
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDD---------IYFQAHKAVLAACSSYFRMMFINH--QHTTAQLNL----SNM 66

                         90
                 ....*....|....*....
gi 974108816 117 GPDPETVEAVIHFMYTGSV 135
Cdd:cd18192   67 KISAECFDLILQFMYLGKI 85
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 169-271 2.65e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 37.79  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816 169 LSLSNCVAVHSLAHMYSLNElALEAAEK-IRRNFHRVIRNE----EFYTLPFHLVRDWLLDSEITVDSELELFEAIVKWV 243
Cdd:cd18473    1 LSPENCCFSANIAARFGLPD-ALKAAEKyIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWL 79

                         90       100
                 ....*....|....*....|....*...
gi 974108816 244 HQNPEeRERYFEELFKLVRLPQIPPTDL 271
Cdd:cd18473   80 NQDES-RLAYANALLSRIRYGLVPVEEL 106
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-153 5.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 37.57  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  43 LSRRQNEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQFSES---QTGRVElrewssaagpd 119
Cdd:cd18213    8 LLQQLNMQREFGFLCDCTVAIGD---------VYFKAHRAVLAAFSNYFKMIFIHQSSECikiQPTDIQ----------- 67

                         90       100       110
                 ....*....|....*....|....*....|....
gi 974108816 120 PETVEAVIHFMYTGSVRVTNANvHDVLELADRFL 153
Cdd:cd18213   68 PDIFSYLLHIMYTGKGPKQSVD-HSRLEEGIRFL 100
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-135 5.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 37.28  E-value: 5.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  43 LSRRQNEQRKAGLFCDLTLVFSSrgassgerhLTLPAHRCVLSAASQYFELLLGGQFSESqtgrVELRewssAAGPDPET 122
Cdd:cd18193    8 LLQQLNAQREFGFLCDCTVAIGD---------VYFKAHKSVLASFSNYFKMLFVHQTSEC----VRLK----PTDIQPDI 70

                         90
                 ....*....|...
gi 974108816 123 VEAVIHFMYTGSV 135
Cdd:cd18193   71 FSYLLHLMYTGKM 83
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 57-135 6.20e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 37.71  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  57 CDLTLVFSSRG----ASSGERHLT---LPAHRCVLSAASQYFELLL------GGQFSESQTGRVELREwssAAGPDpETV 123
Cdd:cd18284    3 GDAVLVFASDKetveSSSGKVNEPdfeLRCHKAILSARSPFFRNLLqrrirtGEDRTLSTPTRIVLDE---SIIPR-RYA 78

                         90
                 ....*....|..
gi 974108816 124 EAVIHFMYTGSV 135
Cdd:cd18284   79 RVLLHAMYTDSV 90
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-173 6.97e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 37.33  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974108816  55 LFCDLTLVfssrgASSGERHltlpAHRCVLSAASQYFELLlggqFSESQTgrveLREWSSAAGpdpetVEAVIHFMYTGS 134
Cdd:cd18243   31 LFCDVTLT-----AQGQQFH----CHKAVLASCSQYFRSL----FSINNL----VLQGCSSIG-----LRLVLEYLYTAN 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974108816 135 VRVTNANVHDVLELADRFLLGQLKNFCADFLVKKLSLSN 173
Cdd:cd18243   89 VTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
Kelch_6 pfam13964
Kelch motif;
578-621 7.62e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 7.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 974108816  578 GEDVFVIGGWRNSGNldrqYRKEAYRYCAEKKRWTLLPPLPQPR 621
Cdd:pfam13964  11 GGYIYVFGGYTNASP----ALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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