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Conserved domains on  [gi|973206459|ref|XP_015222840|]
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PREDICTED: sodium-dependent serotonin transporter [Lepisosteus oculatus]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 264-514 2.85e-92

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11513:

Pssm-ID: 444915  Cd Length: 537  Bit Score: 291.73  E-value: 2.85e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11513  282 DALVTSVVNCLTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDST 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLTYVSAGCGRMGGEGGTPPE--TAVL----------GTG 411
Cdd:cd11513  362 FAGLEGVITAVLDEFPHVWSKRREKFVLGLVIVCFLGSLATLTFGGAYVVKLLEEYATGPAvlTVVLleavavswfyGIT 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 412 GPTLSIISSLLFLCQSQTRVCGSISHPLLplcpsappLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPV 491
Cdd:cd11513  442 QFCNDVKEMLGFSPGWFWRVCWVAISPLF--------LLFIICSFLMNPPQLRLFDYNYPYWSIVVGYCIGTSSIICIPI 513

                        250       260
                 ....*....|....*....|...
gi 973206459 492 YMVYHLITTPGTFKQVSAPCWQP 514
Cdd:cd11513  514 YMAYRLIITPGTLKERIIKSITP 536
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 177-213 9.44e-21

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11497:

Pssm-ID: 444915  Cd Length: 537  Bit Score: 95.46  E-value: 9.44e-21
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11497    1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGG 37
 
Name Accession Description Interval E-value
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
 264-514 2.85e-92

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 291.73  E-value: 2.85e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11513  282 DALVTSVVNCLTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDST 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLTYVSAGCGRMGGEGGTPPE--TAVL----------GTG 411
Cdd:cd11513  362 FAGLEGVITAVLDEFPHVWSKRREKFVLGLVIVCFLGSLATLTFGGAYVVKLLEEYATGPAvlTVVLleavavswfyGIT 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 412 GPTLSIISSLLFLCQSQTRVCGSISHPLLplcpsappLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPV 491
Cdd:cd11513  442 QFCNDVKEMLGFSPGWFWRVCWVAISPLF--------LLFIICSFLMNPPQLRLFDYNYPYWSIVVGYCIGTSSIICIPI 513

                        250       260
                 ....*....|....*....|...
gi 973206459 492 YMVYHLITTPGTFKQVSAPCWQP 514
Cdd:cd11513  514 YMAYRLIITPGTLKERIIKSITP 536
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
 264-498 2.97e-58

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 201.75  E-value: 2.97e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:pfam00209 280 DALIVSFINSATSFLAGFVIFSVLGFMAQEQGVPISEVAES-GPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQ 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLT------------YVSAGCGRMGGEGGTPPETAVLGTG 411
Cdd:pfam00209 359 FGGVEGIITALVDEFPILLRKRRELFTLIVCVASFLLGLILVTeggiyvftlfdyYAASFSLLFVAFFECIAIAWVYGID 438

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  412 GPTLSIISSLLFLCQSQTRVCGSISHPLLplcpsappLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPV 491
Cdd:pfam00209 439 RFYDDIKEMLGFRPGLFWRLCWKFVSPLI--------LLFLFIFSIVQYQPLTYNNYVYPNWANALGWLMALSSMLCIPL 510


                  ....*..
gi 973206459  492 YMVYHLI 498
Cdd:pfam00209 511 YSIYKLL 517
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
 177-213 9.44e-21

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 95.46  E-value: 9.44e-21
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11497    1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGG 37
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
 177-213 7.82e-19

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 89.27  E-value: 7.82e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 973206459  177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGG 37
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
264-387 5.35e-16

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 80.14  E-value: 5.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLgYMADkrqlevaeVAKDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:COG0733  251 SALIVALLDTLVALLAGLAIFPAV-FAFG--------LEPAAGPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSA 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 973206459 344 FAGLEGVITAVLDEFPqvLSKRREWFVLGLVCVCyLGALSTLTY 387
Cdd:COG0733  322 ISLLEVVVAALIDKFG--LSRKKATLIVGLLIFL-LGIPSALSF 362
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
176-213 3.65e-11

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 65.12  E-value: 3.65e-11
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 973206459 176 PRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:COG0733    4 KREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGG 41
 
Name Accession Description Interval E-value
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
 264-514 2.85e-92

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 291.73  E-value: 2.85e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11513  282 DALVTSVVNCLTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDST 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLTYVSAGCGRMGGEGGTPPE--TAVL----------GTG 411
Cdd:cd11513  362 FAGLEGVITAVLDEFPHVWSKRREKFVLGLVIVCFLGSLATLTFGGAYVVKLLEEYATGPAvlTVVLleavavswfyGIT 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 412 GPTLSIISSLLFLCQSQTRVCGSISHPLLplcpsappLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPV 491
Cdd:cd11513  442 QFCNDVKEMLGFSPGWFWRVCWVAISPLF--------LLFIICSFLMNPPQLRLFDYNYPYWSIVVGYCIGTSSIICIPI 513

                        250       260
                 ....*....|....*....|...
gi 973206459 492 YMVYHLITTPGTFKQVSAPCWQP 514
Cdd:cd11513  514 YMAYRLIITPGTLKERIIKSITP 536
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
 264-506 2.59e-75

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 247.61  E-value: 2.59e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11497  284 DALVTSSINCATSFFSGFVIFSVLGYMAHKQNVPIEDVATE-GPGLVFIVYPEAIATLPGSTFWAIIFFLMLITLGLDST 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPqVLSKRREWFVLGLVCVCYLGALSTLTYVSAGCGRmggeggtppetaVLGTGGPTLSIISSLLF 423
Cdd:cd11497  363 FGGLEAVITGLCDEFP-FLSRRRELFVLGLVIICFLLALPTVTYGGIYVVT------------LLDRYAAGISILFIVFF 429

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 424 LCQSQT------------------------RVCGSISHPLLPLcpsapplqFIICSFLFFPPELKLFNYTYPPWTTVLGY 479
Cdd:cd11497  430 EAVAVSwfygvdrfsddieemlgfrpglywRVCWKFISPIFLL--------FIVIFSLVSYEPLQYQDYVYPPWANVVGW 501

                        250       260
                 ....*....|....*....|....*..
gi 973206459 480 CIGVSSFICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11497  502 VIACSSIVLIPIYAIYKLISTPGTFRQ 528
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
 264-498 2.97e-58

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 201.75  E-value: 2.97e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:pfam00209 280 DALIVSFINSATSFLAGFVIFSVLGFMAQEQGVPISEVAES-GPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQ 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLT------------YVSAGCGRMGGEGGTPPETAVLGTG 411
Cdd:pfam00209 359 FGGVEGIITALVDEFPILLRKRRELFTLIVCVASFLLGLILVTeggiyvftlfdyYAASFSLLFVAFFECIAIAWVYGID 438

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  412 GPTLSIISSLLFLCQSQTRVCGSISHPLLplcpsappLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPV 491
Cdd:pfam00209 439 RFYDDIKEMLGFRPGLFWRLCWKFVSPLI--------LLFLFIFSIVQYQPLTYNNYVYPNWANALGWLMALSSMLCIPL 510


                  ....*..
gi 973206459  492 YMVYHLI 498
Cdd:pfam00209 511 YSIYKLL 517
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
 264-506 1.11e-55

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 195.49  E-value: 1.11e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKdAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11496  286 DSIILCFLNSGTSFFAGFAIFSILGFMAQEQGVPISEVAE-SGPGLAFIAYPRAVSLLPLPQLWAVLFFIMLLLLGLDSQ 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSK--RREWFVLGLVCVCYLGALSTLT----YVSAGCGRMggeggtppetAVLGTggptlsi 417
Cdd:cd11496  365 FVGVEGFVTAIVDLYPRVLRRryRREIFVAIVCLVSFLIGLPMVTeggiYVFQLFDYY----------AASGI------- 427

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 418 isSLLFLCQSQT----------RVCGSISH-------PLLPLCPS--APPLQF--IICSFLFFPPeLKLFN-YTYPPWTT 475
Cdd:cd11496  428 --CLLWLAFFECiaiswvygadRFYDNIKDmigyrpgPWWKYCWLfgTPAICLgiFIFSLVKYTP-LTYGNtYVYPWWAE 504

                        250       260       270
                 ....*....|....*....|....*....|.
gi 973206459 476 VLGYCIGVSSFICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11496  505 AIGWFLALSSMLCIPLYAIYELLRTPGTFKE 535
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
 264-506 1.13e-54

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 192.68  E-value: 1.13e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11556  299 DALLTSFINCATSFLSGFVIFSVLGYMAHRSGVPIEDVATE-GPGLVFVVYPEALSTMPGSTFWSLIFFMMLMTLGLDSS 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPqVLSKRREWFVLGLVCVCYLGALSTLT----YVsagcgrmggeggtppeTAVLGTGGPTLSIIS 419
Cdd:cd11556  378 FGGSEAIITALSDEFP-IIKRHRELFVGCLFSFYFVIGLASCTqggfYF----------------FHLLDRYAAGYSILI 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 420 SLLF-------------LCQSQTRVCGSISHPLLPLC-PSAPP--LQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGV 483
Cdd:cd11556  441 AVLFeaiavswiygtdrFCQDIKEMLGFPPGIYWKVCwKFIAPifLLFIITYGLIGYQPLTYDDYVYPTWANALGWCIAG 520

                        250       260
                 ....*....|....*....|...
gi 973206459 484 SSFICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11556  521 SSISMIPIVAIYKLLSTPGTLRQ 543
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
 264-514 1.67e-45

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 167.83  E-value: 1.67e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11512  287 DALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATE-GAGLVFILYPEAISTLSGSTFWAVVFFIMLLTLGIDSS 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFpQVLSKRREWFVLGLVCVCYLGALSTLT----YVsagcgrmggegGTPPETAVLGTggptlSIIS 419
Cdd:cd11512  366 MGGMEAVITGLADDF-SILKKHRKLFTFGVAFITFLLALFCITnggiYV-----------LTLLDTFAAGT-----SILF 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 420 SLLFLCQSQTRVCG--SISHPLLPLCPSAPPLQFIICsFLFFPPELKLF---------------NYTYPPWTTVLGYCIG 482
Cdd:cd11512  429 AVLMEAIGVSWFYGvdRFSDDIQQMMGFRPGLYWRLC-WKFVSPAFLLFvvivsiinfkpltydDYNFPPWANRTGWGIA 507

                        250       260       270
                 ....*....|....*....|....*....|..
gi 973206459 483 VSSFICVPVYMVYHLITTPGTFKQVSAPCWQP 514
Cdd:cd11512  508 LSSMLLVPIYVIYKFFTVPGTFEERLAYCITP 539
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
 264-506 3.19e-44

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 164.33  E-value: 3.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11514  286 DAIITTSINSLTSFFSGFVVFSFLGYMAQKHNVPIGDVAKD-GPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSA 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFpQVLSKRREWFVLGLVCVCYLGALSTLT----YVsagcgrmggegGTPPETAVLGTG---GPTLS 416
Cdd:cd11514  365 MGGMESVITGLIDEF-KFLHRHRELFTLFIVLSTFLISLFCVTnggiYV-----------FTLLDHFAAGTSilfGVLIE 432

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 417 IISSLLFLCqsqtrvCGSISHPLLPLCPSAPPLQFIIC------SFLFF----------PPelKLFNYTYPPWTTVLGYC 480
Cdd:cd11514  433 AIGIAWFYG------VGRFSDDIEEMIGQRPGLYWRLCwkfvspCFLLFvvvvsivtfrPP--KYGSYIFPDWANMVGWC 504

                        250       260
                 ....*....|....*....|....*.
gi 973206459 481 IGVSSFICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11514  505 LAISSMAMVPLYAIYKFCSLPGSFRE 530
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
 264-506 1.32e-41

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 156.83  E-value: 1.32e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11500  282 DTLIITLGNCITSVFAGFAIFSVLGHMAHELGVPVKDVA-DAGPGLAFVAYPEALTLLPVSPFWSILFFFMLLTLGLDSQ 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLTYVSAGCGRMGGEGGTppetavlgtggpTLSIISSLLF 423
Cdd:cd11500  361 FAMLETIVTAVTDEFPYLLRKYKTWFLGLICVGMYLLGLLLVTDGGMYWLTLMDWYSA------------SFGLMVLALF 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 424 LCQSQTRV------CGSIsHPLLPLCPSappLQFIICsFLFFPPELKLF---------------NYTYPPWTTVLGYCIG 482
Cdd:cd11500  429 MCLAISWVygiqrfCRDI-KMMIGFEPN---LYFKAC-WMFISPALLLFilvysivkyqpseygSYRYPPWAELLGILMG 503

                        250       260
                 ....*....|....*....|....
gi 973206459 483 VSSFICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11500  504 LLSCLMIPIGAIVAILREEGSLWE 527
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
 178-386 1.87e-40

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 151.14  E-value: 1.87e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 178 ETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG--------------------ERQGSGRGRQQGGSAER------- 230
Cdd:cd10324    1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGaflipylimlflvgiplfylELALGQYTSRGPVGAFWriaplfk 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 231 --GEFSCTTSL----YTKVRVAIAM-----SFMPLPLPLRPPLR------------------------------------ 263
Cdd:cd10324   81 gvGYAQVLVSFlvaiYYNVIIAWTLyylfaSFINWELFLCLLLAwilvylckgvksigkgvkftgpfpyvlllfllirgv 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 -----------------------------------------------------------DALVTSSVNCLTSFMSGFVIF 284
Cdd:cd10324  161 tlpgagdgilfyltpdwsklldpkvwiaaatqiffslgigfgglityasynkfknniyrDALIVAILNTLTSLLAGFVIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 285 TVLGYMADKRQLEVAEVAKDaGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLDEFPQvLSK 364
Cdd:cd10324  241 SILGFLAHEPGTPVEDVVAS-GPGLAFIVYPEAIAQMPGPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALADEFPK-LRK 318

                        330       340
                 ....*....|....*....|..
gi 973206459 365 RREWFVLGLVCVCYLGALSTLT 386
Cdd:cd10324  319 RRWLVTLGVCVVGFLLGLPYTT 340
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
 264-516 1.48e-36

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 143.19  E-value: 1.48e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAKdAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11506  318 DSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRPIADVAA-SGPGLAFLAYPEAVTQLPISPLWAVLFFSMLLMLGIDSQ 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVLGLVCVCYLGALSTLT-----------YVSAGCgrmggeggtppetavlgtgg 412
Cdd:cd11506  397 FCTVEGFITALVDEFPRLLRNRREIFIAVVCIVSYLIGLSNITqggiyvfklfdYYSASG-------------------- 456

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 413 ptLSIISSLLFLCQSQTRVCG--SISHPLLPLCPSAPPLQFIICsFLFFPP---------------ELKLFNYTYPPWTT 475
Cdd:cd11506  457 --MSLLFLVFFECVSISWFYGvnRFYDNIEEMVGYRPCIWWKLC-WSFFTPiivagvflfsavqmtPLTMGNYVFPKWGQ 533

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 973206459 476 VLGYCIGVSSFICVPVYMVYHLITTPGTFKQVSAPCWQPSE 516
Cdd:cd11506  534 GVGWFMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPTE 574
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
 264-520 1.53e-36

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 143.22  E-value: 1.53e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11499  311 DTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVA-DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTM 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVLGlVCVCYL---------GALSTLTYVSAGCGRMGGEGgtppeTAVLGTGGpt 414
Cdd:cd11499  390 FATIETIVTSVSDEFPKYLRTHKPQFTLV-CCLSFFimgfpmitqGGIYMLQLVDTYAASYSLVI-----IAIFELVG-- 461

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 415 LSIISSLLFLCQSQTRVCGSISHPLLPLC---PSAPPLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPV 491
Cdd:cd11499  462 ISYIYGLQRFCEDIEMMIGFQPNKFWKVCwafVTPTILTFILAFSFYQWEPMTYGSYTYPNWSMVLGWLMLACSVIWIPI 541

                        250       260       270
                 ....*....|....*....|....*....|...
gi 973206459 492 YMVYHLITTPGTF----KQVSAPcwQPSETPVL 520
Cdd:cd11499  542 MFVIKMHLAPGSFierlKLVCSP--QPDWGPFL 572
SLC6sbd_BGT1 cd11511
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding ...
 264-506 6.78e-36

Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain; BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212080  Cd Length: 541  Bit Score: 140.44  E-value: 6.78e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11511  284 DCIMLCFLNSATSFVAGFAIFSVLGFMAREQGVPISEVA-ESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQ 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSK--RREWFVLGLVCVCYLGALSTLT----YVSAGCGrmggeggtppetaVLGTGGPTLSI 417
Cdd:cd11511  363 FVCVESMVTASIDMFPGVFRKkgRRELLILAIAVICYLLGLLLVTeggmYIFQLFD-------------YYAASGTCLLF 429

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 418 ISSLLFLCQS----QTRVCGSISH-------PLLPLCPSAPPLQFIICSFLF----FPPeLKLFN-YTYPPWTTVLGYCI 481
Cdd:cd11511  430 LAIFEVICIGwvygANRFYDNIEDmigyrpwPLIKICWLVFTPGLCLAVFLFslikYTP-LKYNNsYVYPPWGYVLGWLM 508

                        250       260
                 ....*....|....*....|....*
gi 973206459 482 GVSSFICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11511  509 ALSSMVCIPLYAIFILLKTKGSLKQ 533
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
 264-510 5.13e-34

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 134.98  E-value: 5.13e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11510  285 DCLLLGCLNSGTSFVSGFAIFSVLGFMAQEQGVDIADVA-ESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQ 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSK--RREWFVlglVCVCYLGALSTLTYVSAGCGRMGGEGGTPPETAVLGTGGPTLSIISSL 421
Cdd:cd11510  364 FVEVEGQITSLVDLYPSFLRKgyRREIFI---AIVCFISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVA 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 422 LF-----LCQSQTRVCGSISHPLLPLCPSAPPLQFIICSFLF----FPPELKLFNYTYPPWTTVLGYCIGVSSFICVPVY 492
Cdd:cd11510  441 WVyggdnMYDAIEDMIGYRPGPWMKYSWIVITPVLCVGCFIFslvkYEPLTYNKVYVYPEWAIGLGWVLALSSMICIPMV 520

                        250       260
                 ....*....|....*....|..
gi 973206459 493 MVYHLITTPGTF----KQVSAP 510
Cdd:cd11510  521 AVIRIIQTDGPLieriKALTTP 542
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
 264-519 2.15e-30

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 124.96  E-value: 2.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11509  294 DAFILALINSGTSFFAGFVVFSILGFMASEQGVDISKVA-ESGPGLAFIAYPKAVTLMPVAPLWAALFFFMLLLLGLDSQ 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKR--REWFVLGLVCVCYLGALSTLT----YVSAGCGRMGGEGGTPPETA---------VL 408
Cdd:cd11509  373 FVGVEGFITGILDLLPAKYYFRyqREVVVALCCLLCFLIDLSMVTeggmYVFQLFDYYSASGTTLLWQAfwecvvvawVY 452

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 409 GTGGPTLSIISSLLFLCQSQTRVCGSISHPLlpLCpsappLQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFIC 488
Cdd:cd11509  453 GADRFMDDIARMIGYRPLPWMKWCWSVITPL--VC-----MGIFLFHVVNYKPLTYNKTYVYPWWGEAIGWCLALSSMLC 525

                        250       260       270
                 ....*....|....*....|....*....|.
gi 973206459 489 VPVYMVYHLITTPGTFKQVsapcWQPSETPV 519
Cdd:cd11509  526 IPLTVLYKLLRAKGSLKER----WQKLTTPV 552
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
 264-510 5.78e-29

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 120.47  E-value: 5.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11507  282 DCIALCFLNSGTSFVAGFAIFSILGFMAEEQGVPISEVA-ESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQ 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSK--RREWFVLGLVCVCYLGALSTLT----YVSAGCGrmggeggtppetaVLGTGGPTLSI 417
Cdd:cd11507  361 FVCVESLVTALVDMYPTIFRKknRRELLILAVSIVSFLVGLIMLTeggmYVFQLFD-------------YYAASGMCLLF 427

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 418 ISSLLFLCQS----QTRVCGSISH-------PLLPLCPSAPPLQFIICSFLF----FPPELKLFNYTYPPWTTVLGYCIG 482
Cdd:cd11507  428 VAIFETLCVAwvygADRFYDNIEDmigyrpwAIIKYCWLFITPAVCMATFLFslikYTPLTYNKKYVYPWWGDALGWLLA 507

                        250       260       270
                 ....*....|....*....|....*....|..
gi 973206459 483 VSSFICVPVYMVYHLITTPGT----FKQVSAP 510
Cdd:cd11507  508 LSSMVCIPLWVGYKLSTIKGSlrerFRQLTCP 539
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
 264-516 5.55e-28

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 118.06  E-value: 5.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11501  307 DAIVVCVTNCLTSVFAGFAIFSVLGHMAHVSGRPVSEVV-DSGFDLAFIAYPEALSKLPISPLWSILFFFMLLTLGLDSQ 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRRE---------WFVLGLVCVCYLGA--LSTLTYVSAGCGRMGGEGGTPPETAVLGTGG 412
Cdd:cd11501  386 FASIETITTTIQDAYPKVMKKMRIpitlgvcviLFLLGLVCVTQAGIywVNLIDHFCAGWGILFAAVLELVGIIWIYGGN 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 413 PTLSII-------SSLLFLCQsqtRVCGSISHPLLPLcpsappLQFIICSFLFFPPELKlfNYTYPPWTTVLGYCIGVSS 485
Cdd:cd11501  466 RFIEDIemmigakSWIFWLWW---RACWFFITPVLLI------AILIWSLVTFHSPTYG--SVPYPDWGTALGWCMIIFC 534

                        250       260       270
                 ....*....|....*....|....*....|.
gi 973206459 486 FICVPVYMVYHLITTPGTFKQVSAPCWQPSE 516
Cdd:cd11501  535 LIWIPIVAVIKIIKAKGNLFQRIKSCCRPTS 565
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
 264-506 8.34e-27

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 113.93  E-value: 8.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11508  285 DCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVA-ESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQ 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEFPQVLSK--RREWFVLGLVCVCYLGALSTLTYVSAGCGRMGGEggtppetavLGTGGPTLSIISSL 421
Cdd:cd11508  364 FVCVESLVTAVVDMYPKVFRRgyRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDS---------YAASGMCLLFVAIF 434

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 422 LFLCQSQTRVCGSISHPLLPLCPSAPPL------QFI---ICS--FLFFPPE---LKLFN-YTYPPWTTVLGYCIGVSSF 486
Cdd:cd11508  435 ECICIGWVYGSNRFYDNIEDMIGYRPLSlikwcwMVItpgICAgiFIFFLVKykpLKYNNvYTYPDWGYGIGWLMALSSM 514

                        250       260
                 ....*....|....*....|
gi 973206459 487 ICVPVYMVYHLITTPGTFKQ 506
Cdd:cd11508  515 ICIPLWICIKMWKTEGTFPE 534
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
 264-506 3.44e-26

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 112.32  E-value: 3.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEVAkDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11498  313 DSIIISITNCATSVYAGFVIFSILGFMANHLGVDVSEVA-DHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQ 391

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 344 FAGLEGVITAVLDEF-PQVLSKRREWFVLGLVCVCYLGALSTLTYVSAGCGRMGGEGgtppetavlgTGGPTLSIISSLL 422
Cdd:cd11498  392 FCLLETLVTAVVDEIgNDWIIRNKTYVTLGVAIIGFLLGIPLTTQAGIYWLLLMDNY----------AASFSLVIISCIM 461

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 423 FLCQSQTRVCGSISHPLLPLCPSAPPLQFIICsFLFFPPELKLF---------------NYTYPPWTTVLGYCIGVSSFI 487
Cdd:cd11498  462 CIAIMYIYGHRNYFKDIEMMLGFPPPLFFQIC-WRFVSPAIIFFiliftviqyrpitynDYVYPGWAIVIGFLMALSSVI 540

                        250       260
                 ....*....|....*....|
gi 973206459 488 CVPVYMVYHLITTPG-TFKQ 506
Cdd:cd11498  541 CIPIYAIFKICMSEGdTFLE 560
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
 264-377 2.76e-23

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 103.12  E-value: 2.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGY------------MADKRQLEVAEVAKDA-GPSLLFIIYAEAIANMPASTFFAII 330
Cdd:cd10332  271 DAVLVSLINCFTSIFASIVVFSVLGFkinnvtltenqtLGLTNCSLEDELDEAVqGTGLAFIVFTEAITKMPGAPFWSVL 350

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 973206459 331 FFLMIITLGLDSTFAGLEGVITAVLDEfpQVLSKRREWFVLGLVCVC 377
Cdd:cd10332  351 FFLMLLTLGLGSMFGTLEGVVTPLFDS--KILPKVPKEYLTGLVCLV 395
SLC6sbd_u2 cd11554
uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins ...
 264-387 5.12e-21

uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, and are the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 212092 [Multi-domain]  Cd Length: 406  Bit Score: 95.08  E-value: 5.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMAdkRQLEVAEVAKdAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd11554  219 DALIIAGSNSLFEIIAGFAVFGIVGYLG--MTPGVEGEAL-GGFVLGFVTYPEAIAQMPGSNFFAVLFFLTLFLLGISSA 295

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRreWFVlgLVCVCYLGALSTLTY 387
Cdd:cd11554  296 FALLEAVVTLICDSGWGRKVKR--WWI--ATVVCFVSFLLSLPY 335
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
 177-213 9.44e-21

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 95.46  E-value: 9.44e-21
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11497    1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGG 37
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
 177-213 7.82e-19

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 89.27  E-value: 7.82e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 973206459  177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGG 37
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
 177-213 4.90e-18

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 87.19  E-value: 4.90e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11513    1 RETWGKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 37
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
 177-213 5.90e-18

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 86.75  E-value: 5.90e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11556    1 RETWSKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGG 37
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
 177-213 1.74e-17

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 85.32  E-value: 1.74e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11496    1 RGKWSNKIDFLLSVAGYAIGLGNVWRFPYLCYKNGGG 37
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
 177-213 2.15e-16

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 81.90  E-value: 2.15e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11514    1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGG 37
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
264-387 5.35e-16

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 80.14  E-value: 5.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLgYMADkrqlevaeVAKDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:COG0733  251 SALIVALLDTLVALLAGLAIFPAV-FAFG--------LEPAAGPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSA 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 973206459 344 FAGLEGVITAVLDEFPqvLSKRREWFVLGLVCVCyLGALSTLTY 387
Cdd:COG0733  322 ISLLEVVVAALIDKFG--LSRKKATLIVGLLIFL-LGIPSALSF 362
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
 177-213 8.59e-16

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 80.01  E-value: 8.59e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11512    1 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGG 37
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
 264-388 4.66e-14

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 74.60  E-value: 4.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADK-RQLEVAEVAKDA------------GPSLLFIIYAEAIANMPASTFFAII 330
Cdd:cd11515  273 DAVLVSFINFFTSVLATLVVFAVLGFKIQKvKEEEFPALHLNPcliedelnkavqGTGLAFIAFTEAMTHFPASPFWSVM 352

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 973206459 331 FFLMIITLGLDSTFAGLEGVITAVLDEFpqvlSKRREWFVLGlvcVCYLGALSTLTYV 388
Cdd:cd11515  353 FFLMLVNLGLGSMFGTIEGITTPIVDTF----KVRKEILTVI---CCLLAFCIGLIFV 403
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
 177-213 1.53e-13

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 72.96  E-value: 1.53e-13
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11509    1 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGG 37
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
 177-213 1.99e-13

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 72.48  E-value: 1.99e-13
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11500    1 RGQWGGKLEFLLSCIGYCVGLGNVWRFPYLCYRNGGG 37
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
 177-213 7.09e-13

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 70.76  E-value: 7.09e-13
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd10332    1 RPAWDNKLQFLLATIGYAVGLGNVWRFPYLCQKNGGG 37
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
 177-213 1.87e-12

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 69.65  E-value: 1.87e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11499    1 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGG 37
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
 177-213 1.92e-12

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 69.45  E-value: 1.92e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd10334    1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGG 37
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
 264-386 2.85e-12

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 68.62  E-value: 2.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFT-VLGYMADKrqlevaevakDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDS 342
Cdd:cd10336  246 SALIVAVLDTLVALLAGLVIFPaVFAFGLDP----------AAGPGLLFITLPAVFAQMPGGRLFGILFFLLLLFAALTS 315

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 973206459 343 TFAGLEGVITAVLDEFPQVLSKRREW-----FVLGLVCVCYLGALSTLT 386
Cdd:cd10336  316 AISLLEVVVAYLIDEFGWSRKKATLIvgiiiFLLGIPSALSFGVLSDVT 364
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
 177-213 2.93e-12

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 69.14  E-value: 2.93e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11501    1 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYKNGGG 37
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
 177-213 3.49e-12

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 68.73  E-value: 3.49e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11510    1 REKWASKIDFLLSVAGGFVGLGNVWRFPYLCYKNGGG 37
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
 264-389 7.59e-12

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 67.46  E-value: 7.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMAD---------------------------KRQLEVAEVAKdaGPSLLFIIYAE 316
Cdd:cd11502  271 DAFLVALVNLVTSLLTTPFIFAVLGFWATpasiylswlnnlpqhiksqvlskvpecSIQKQKEKIME--GPGFAFLAFSE 348

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 973206459 317 AIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLDEFpqvlSKRREWFVLGLVCVCYLGALSTLTYVS 389
Cdd:cd11502  349 AISLFPGSSFWSILFFLMLLILGLSTMLGIMQGIITPLQDTF----SFFRKHPKLLTVGVCLLMFLCSLIFTR 417
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
176-213 3.65e-11

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 65.12  E-value: 3.65e-11
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 973206459 176 PRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:COG0733    4 KREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGG 41
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
 305-382 3.98e-11

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 65.61  E-value: 3.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 305 AGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLDEfpQVLSKR--REWFVlGLVC-VCYLGA 381
Cdd:cd11517  364 SGPGLAFIVFTEAVLHMPGAQVWAVLFFGMLFTLGLSSMFGNVEGVITPLLDV--GVLPRWvpKEALT-GLVClVCFLSA 440


                 .
gi 973206459 382 L 382
Cdd:cd11517  441 L 441
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
 177-213 1.12e-10

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 64.17  E-value: 1.12e-10
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11498   17 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGG 53
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
 306-388 3.15e-10

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 62.63  E-value: 3.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 306 GPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLDEFpqvlSKRREwfVLGLVCvCYLGALSTL 385
Cdd:cd11522  378 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIITPIVDTF----KVRKE--ILTVIC-CLLAFCIGL 450


                 ...
gi 973206459 386 TYV 388
Cdd:cd11522  451 IFV 453
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
 177-213 5.94e-10

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 61.53  E-value: 5.94e-10
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11507    1 RGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGG 37
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
 177-213 9.38e-10

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 61.15  E-value: 9.38e-10
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11521    1 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGG 37
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
 177-213 1.70e-09

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 60.34  E-value: 1.70e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11515    1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGG 37
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
 306-382 1.90e-09

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 59.99  E-value: 1.90e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973206459 306 GPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLDEFpqvlSKRREWFVLGLVCVCYLGAL 382
Cdd:cd11521  378 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMSGITTPIIDTF----KVRKEVFTVGCCIFAFLVGL 450
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
 177-213 5.60e-09

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 58.46  E-value: 5.60e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11508    2 RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGG 38
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
 177-213 6.29e-09

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 58.39  E-value: 6.29e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11522    1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGG 37
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
 306-382 7.59e-09

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 58.36  E-value: 7.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 306 GPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLD--EFPQVLSKRrewFVLGLVC-VCYLGAL 382
Cdd:cd11516  364 GTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVLVPLQDlkVIPKSWPKE---IITGLIClVSFLIGL 440
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
 177-213 2.33e-08

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 56.75  E-value: 2.33e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11517    2 RPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGG 38
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
 178-213 3.89e-08

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 55.52  E-value: 3.89e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 973206459 178 ETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd10336    1 EQWSSRLGFILAAAGSAVGLGNIWRFPYLAGENGGG 36
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
 177-213 8.12e-08

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 54.96  E-value: 8.12e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11518    4 RPLWDNPLQFVFACISYAVGLGNVWRFPYLCQMYGGG 40
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
 306-385 1.84e-07

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 53.81  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 306 GPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDSTFAGLEGVITAVLDEfpQVLSKR--REwFVLGLVCV--CYLGA 381
Cdd:cd11518  369 GTGLAFIVYTEAIKNMEVSQLWSVLYFLMLLMLGIGSMLGNTAAILTPLTDS--KFISSHlpKE-AISGLLCFtnCIIGL 445


                 ....
gi 973206459 382 LSTL 385
Cdd:cd11518  446 VFTM 449
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
 177-213 3.20e-07

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 52.97  E-value: 3.20e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11516    1 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGG 37
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
 177-213 3.90e-07

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 52.82  E-value: 3.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd11502    1 RPLWSKKTEYILAQVGFSVGLSSIWRFPYLWHHNGGG 37
SLC5-6-like_sbd cd06857
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 264-383 1.77e-06

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


Pssm-ID: 271356 [Multi-domain]  Cd Length: 407  Bit Score: 50.43  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459 264 DALVTSSVNCLTSFMSGFVIFTVLGYMADKRQLEVAEvAKDAGPSLLFIIYAEAIANMPASTFFAIIFFLMIITLGLDST 343
Cdd:cd06857  215 DALIAAFLNLIASIIFVGLIGIAAGVLSFDPQNMVVL-GLLNSLYLTFIASPQAISSLAGSNLWAFLYYAALLLAGLSSM 293

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 973206459 344 FAGLEGVITAVLDEFPQVLSKRREWFVL---GLVCVCYLGALS 383
Cdd:cd06857  294 ATITNTVAQSLFDEFRRKLKTGVIDTALivvLLVAAVIFLVLG 336
LeuT-like_sbd cd10333
Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino ...
 177-213 5.92e-06

Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.


Pssm-ID: 271365 [Multi-domain]  Cd Length: 496  Bit Score: 48.85  E-value: 5.92e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 973206459 177 RETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGG 213
Cdd:cd10333    1 REHWGSRIGLILAMAGNAVGLGNFLRFPVQAAQNGGG 37
DUF418 pfam04235
Protein of unknown function (DUF418); Probable integral membrane protein.
 358-496 6.57e-03

Protein of unknown function (DUF418); Probable integral membrane protein.


Pssm-ID: 427807  Cd Length: 163  Bit Score: 37.58  E-value: 6.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  358 FPQVLSKRREWFVLGLVCVCyLGALSTLTYVSAGCGRMGGEGGTPPETAVLGTGGPTLSI--ISSLLFLCQsqTRVCGSI 435
Cdd:pfam04235   7 FTDGEEHRRLLRRLLAIGLA-VGLPLNLLLAWLALLGWESPILGLLLFILSMLGGLALALgyAALILLLFR--KEKRRRL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973206459  436 SHPLlplcpsAPP---------LQFIICSFLFFPPELKLFNYTYPPWTTVLGYCIGVSSFICVPVYMVYH 496
Cdd:pfam04235  84 LRPL------AAVgrmaltnylLQSIICTLLFYGYGLGLFGSLGRAALLLLALGIWALQLLFSKLWLRRF 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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