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Conserved domains on  [gi|972974494|ref|XP_015204189|]
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PREDICTED: thyroid hormone receptor-associated protein 3 isoform X2 [Lepisosteus oculatus]

Protein Classification

BCLAF1 and THRAP3 family protein( domain architecture ID 12173452)

BCLAF1 and THRAP3 family protein is an RNA processing factor that plays critical roles in maintaining DNA genomic stability, such as the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) and thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 199-781 4.74e-132

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 412.25  E-value: 4.74e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  199 RPDSAAKEAQRAGSRDEEAAGAAGGEGAPD--RASGSWQGLIDYDTSPKRTSPavrsaiivsqgtahpspsLQSVAVKR- 275
Cdd:pfam15440  49 RSKRWRMDDKKHGQKDPRISPHGNDHNRSYehRSPDAKSSEASKSWSPKRRSP------------------LESVYVYKp 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  276 ---PSPAVKGGSPSPSRSSAAAQSKSLGNAP------WQSSGPAPTSKSPPQQSPTAVFSGFGFFSKDDVRAGEKP---- 342
Cdd:pfam15440 111 sprPSPERGDSSRRDQYMPKPSEPSPYQYSPkqqgryHGRGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQQSPrrgs 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  343 ---SSVSTAFKKFLEEHKNKIQVAEWENGREKEQKMAELERDKGNGKAGSFDKGAAYSGLKPDYYS-----------KNE 408
Cdd:pfam15440 191 eefSARSSFQKRYPEEQDFRKYGHTSERGKEKEQKDARYEKREPARNSKWKDEHSLPPYQEKDDQRnkgpqssryaeRES 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  409 EEKYGYDDEFELgSAAEFLKGPQFGSAEAGEDqekrhkvrnqkeremEDEPKHKSKITI--TANRDMFDERFNKWDELAY 486
Cdd:pfam15440 271 PESYDYRHKFEK-KLAEFEKDFSDGRTEKYEK---------------EDRKKFSSKISKgnRESDCFSEGRGRKTEEGQV 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  487 FPSAKEKLRKEEDAGEDDIDDVEEELYRSRKQEraaaaaaaakkaeasgyrgfspDKAPKASRKKEKQGQSPSppaRKSS 566
Cdd:pfam15440 335 EPSAKEKSKKDEIACTDSMENDVYLERFNDKKE----------------------EKSKKEGDFRKEAELSSS---SQHD 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  567 ENREreMFNVRRDDSPPrstpAYSGKRSAEVSVRMDPFHEDYASSSGVLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQ 646
Cdd:pfam15440 390 DSRE--KPDVKESSPKS----VFSIKRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQEFRSIFEHIQSQQ 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  647 LRRSPSELFAQHIVTIVHHIKAQHFESSGMTLNERFAMYQRRAA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKS 724
Cdd:pfam15440 464 SERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRAAeqEEMKSNKSPEIHRRIDMSPSALRKHRTLFEESKQ 543

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 972974494  725 SRESSSKDEgkKMKTDSMDLRLDIERRKKYSSKEREHKRDGMRDSGESRGSSLSRER 781
Cdd:pfam15440 544 SKESSYKEG--KVKEDPNDLRHDIERRRKERLKERDEKRFHIRDSQDSRFSSLSRER 598
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 199-781 4.74e-132

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 412.25  E-value: 4.74e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  199 RPDSAAKEAQRAGSRDEEAAGAAGGEGAPD--RASGSWQGLIDYDTSPKRTSPavrsaiivsqgtahpspsLQSVAVKR- 275
Cdd:pfam15440  49 RSKRWRMDDKKHGQKDPRISPHGNDHNRSYehRSPDAKSSEASKSWSPKRRSP------------------LESVYVYKp 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  276 ---PSPAVKGGSPSPSRSSAAAQSKSLGNAP------WQSSGPAPTSKSPPQQSPTAVFSGFGFFSKDDVRAGEKP---- 342
Cdd:pfam15440 111 sprPSPERGDSSRRDQYMPKPSEPSPYQYSPkqqgryHGRGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQQSPrrgs 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  343 ---SSVSTAFKKFLEEHKNKIQVAEWENGREKEQKMAELERDKGNGKAGSFDKGAAYSGLKPDYYS-----------KNE 408
Cdd:pfam15440 191 eefSARSSFQKRYPEEQDFRKYGHTSERGKEKEQKDARYEKREPARNSKWKDEHSLPPYQEKDDQRnkgpqssryaeRES 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  409 EEKYGYDDEFELgSAAEFLKGPQFGSAEAGEDqekrhkvrnqkeremEDEPKHKSKITI--TANRDMFDERFNKWDELAY 486
Cdd:pfam15440 271 PESYDYRHKFEK-KLAEFEKDFSDGRTEKYEK---------------EDRKKFSSKISKgnRESDCFSEGRGRKTEEGQV 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  487 FPSAKEKLRKEEDAGEDDIDDVEEELYRSRKQEraaaaaaaakkaeasgyrgfspDKAPKASRKKEKQGQSPSppaRKSS 566
Cdd:pfam15440 335 EPSAKEKSKKDEIACTDSMENDVYLERFNDKKE----------------------EKSKKEGDFRKEAELSSS---SQHD 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  567 ENREreMFNVRRDDSPPrstpAYSGKRSAEVSVRMDPFHEDYASSSGVLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQ 646
Cdd:pfam15440 390 DSRE--KPDVKESSPKS----VFSIKRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQEFRSIFEHIQSQQ 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  647 LRRSPSELFAQHIVTIVHHIKAQHFESSGMTLNERFAMYQRRAA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKS 724
Cdd:pfam15440 464 SERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRAAeqEEMKSNKSPEIHRRIDMSPSALRKHRTLFEESKQ 543

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 972974494  725 SRESSSKDEgkKMKTDSMDLRLDIERRKKYSSKEREHKRDGMRDSGESRGSSLSRER 781
Cdd:pfam15440 544 SKESSYKEG--KVKEDPNDLRHDIERRRKERLKERDEKRFHIRDSQDSRFSSLSRER 598
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 199-781 4.74e-132

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 412.25  E-value: 4.74e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  199 RPDSAAKEAQRAGSRDEEAAGAAGGEGAPD--RASGSWQGLIDYDTSPKRTSPavrsaiivsqgtahpspsLQSVAVKR- 275
Cdd:pfam15440  49 RSKRWRMDDKKHGQKDPRISPHGNDHNRSYehRSPDAKSSEASKSWSPKRRSP------------------LESVYVYKp 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  276 ---PSPAVKGGSPSPSRSSAAAQSKSLGNAP------WQSSGPAPTSKSPPQQSPTAVFSGFGFFSKDDVRAGEKP---- 342
Cdd:pfam15440 111 sprPSPERGDSSRRDQYMPKPSEPSPYQYSPkqqgryHGRGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQQSPrrgs 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  343 ---SSVSTAFKKFLEEHKNKIQVAEWENGREKEQKMAELERDKGNGKAGSFDKGAAYSGLKPDYYS-----------KNE 408
Cdd:pfam15440 191 eefSARSSFQKRYPEEQDFRKYGHTSERGKEKEQKDARYEKREPARNSKWKDEHSLPPYQEKDDQRnkgpqssryaeRES 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  409 EEKYGYDDEFELgSAAEFLKGPQFGSAEAGEDqekrhkvrnqkeremEDEPKHKSKITI--TANRDMFDERFNKWDELAY 486
Cdd:pfam15440 271 PESYDYRHKFEK-KLAEFEKDFSDGRTEKYEK---------------EDRKKFSSKISKgnRESDCFSEGRGRKTEEGQV 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  487 FPSAKEKLRKEEDAGEDDIDDVEEELYRSRKQEraaaaaaaakkaeasgyrgfspDKAPKASRKKEKQGQSPSppaRKSS 566
Cdd:pfam15440 335 EPSAKEKSKKDEIACTDSMENDVYLERFNDKKE----------------------EKSKKEGDFRKEAELSSS---SQHD 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  567 ENREreMFNVRRDDSPPrstpAYSGKRSAEVSVRMDPFHEDYASSSGVLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQ 646
Cdd:pfam15440 390 DSRE--KPDVKESSPKS----VFSIKRESTVKVDMDKFDEDLARPSSSLAQERQLSRDLVHSGKKDQEFRSIFEHIQSQQ 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972974494  647 LRRSPSELFAQHIVTIVHHIKAQHFESSGMTLNERFAMYQRRAA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKS 724
Cdd:pfam15440 464 SERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRAAeqEEMKSNKSPEIHRRIDMSPSALRKHRTLFEESKQ 543

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 972974494  725 SRESSSKDEgkKMKTDSMDLRLDIERRKKYSSKEREHKRDGMRDSGESRGSSLSRER 781
Cdd:pfam15440 544 SKESSYKEG--KVKEDPNDLRHDIERRRKERLKERDEKRFHIRDSQDSRFSSLSRER 598
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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