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Conserved domains on  [gi|955306610|ref|XP_014621457|]
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protein DETOXIFICATION 9 isoform X1 [Glycine max]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 28-465 3.42e-158

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 455.49  E-value: 3.42e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  28 ELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLvSFSGVAIATSFAEVTGFCVLMGMAGALETLCGQTYGAEEFSEI 107
Cdd:cd13132    1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKL-ELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPISMLWIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQSMIFPMVFSSI 187
Cdd:cd13132   80 GVYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 188 AVLCLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCF 267
Cdd:cd13132  160 VALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 268 EMWSFELLTLFAGLLPnPQLQTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIV 347
Cdd:cd13132  240 EWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 348 SIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFLLGFV 427
Cdd:cd13132  319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 955306610 428 LHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQKEATK 465
Cdd:cd13132  399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 28-465 3.42e-158

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 455.49  E-value: 3.42e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  28 ELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLvSFSGVAIATSFAEVTGFCVLMGMAGALETLCGQTYGAEEFSEI 107
Cdd:cd13132    1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKL-ELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPISMLWIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQSMIFPMVFSSI 187
Cdd:cd13132   80 GVYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 188 AVLCLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCF 267
Cdd:cd13132  160 VALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 268 EMWSFELLTLFAGLLPnPQLQTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIV 347
Cdd:cd13132  240 EWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 348 SIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFLLGFV 427
Cdd:cd13132  319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 955306610 428 LHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQKEATK 465
Cdd:cd13132  399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 38-379 1.94e-47

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 167.04  E-value: 1.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610   38 PMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIAtSFAEVTGFCVLMGMAGALETLCGQTYGAEEFSEIGNYTFCAIVT 117
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGP-VDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  118 LLLVCLPISMLWIFVDKILL-LFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQSMIFPMVFSSIAVLCLHVPI 196
Cdd:TIGR00797  79 ALLLGLPVLLVGYFFIDPLLsLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  197 CWALVFKL--ALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCFEMWSFEL 274
Cdd:TIGR00797 159 NYILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  275 LTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIVSIFFVCC 354
Cdd:TIGR00797 239 LALLVARLGSIAL--AAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316

                         330       340
                  ....*....|....*....|....*
gi 955306610  355 RHILGYAYSNDKEVVDYVSDIVPIL 379
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFV 341
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
29-452 4.44e-47

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 168.40  E-value: 4.44e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  29 LKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATS-FAEVTGFCVLMGMAGAleTLCGQTYGAEEFSEI 107
Cdd:COG0534    7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGT-AALAAVGLAFPiFFLLIALGIGLGVGGT--ALVAQALGAGDREEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPISML-WIFVDKILLLFGQDPEISHVAHEY---CIYSIPALYGFAVLQCQIRyfQTQSMIFPMV 183
Cdd:COG0534   84 RRVLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYlriILLGLPFLLLFNVLNGILR--GLGDTKTPMI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 184 FSSIAVLcLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGL 263
Cdd:COG0534  162 IMLIGNV-LNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 264 MFCFEMWSFELLTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVD 343
Cdd:COG0534  241 QQLAESLGFLVLNALVARLGTAAV--AAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 344 GVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFL 423
Cdd:COG0534  319 GLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYL 398

                        410       420
                 ....*....|....*....|....*....
gi 955306610 424 LGFvLHFNAKGLWMGSLTGSVLQVIILTV 452
Cdd:COG0534  399 LAF-LGLGLTGVWLALPIGEVLRALLLLL 426
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 28-442 2.33e-26

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 111.06  E-value: 2.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  28 ELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAeVTGFCVLMGMAGALETLCGQTYGAEEFSEI 107
Cdd:PRK01766  10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSA-TDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPI-SMLWIFVDKILLLFGQDPEISHVAHEY---CIYSIPALYGFAVLQCQIRYF-QTQSMifpM 182
Cdd:PRK01766  88 AHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQVLRSFIDGLgKTKPT---M 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 183 VFSSIAVLcLHVPICWALVF-KL---ALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNA--LLSIPEFCQ 256
Cdd:PRK01766 165 VIGFLGLL-INIPLNYIFIYgKFgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKpdWAVIKRLLK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 257 FAIPSGLMFCFEMWSFELLTLFAGllpnpQLQTSVLS---VCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIV 333
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVS-----PLGTVTVAahqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 334 RVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVpILCGSFT-ADSLIGALSGIARGGGFQQIGAYVNLGA 412
Cdd:PRK01766 319 YIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLL-LFAALFQfSDAIQVIGSGALRGYKDTRVIFFITFIA 397

                        410       420       430
                 ....*....|....*....|....*....|
gi 955306610 413 YYLVGVPLAFLLGFVLHFNAKGLWMGSLTG 442
Cdd:PRK01766 398 YWVLGLPLGYILALTDPMGPFGFWIGLIIG 427
MatE pfam01554
MatE; The MatE domain
 38-198 1.39e-23

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 96.87  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610   38 PMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAEVTGFcVLMGMAGALETLCGQTYGAEEFSEIGNYTFCAIVT 117
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGA-VALAAVSIANSIASLIFM-FLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  118 LLLVCLPISML-WIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQS-MIFPMVFSSIAVLcLHVP 195
Cdd:pfam01554  79 GLLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGdTKPPMYINIISLL-LNIP 157


                  ...
gi 955306610  196 ICW 198
Cdd:pfam01554 158 LNY 160
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 28-465 3.42e-158

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 455.49  E-value: 3.42e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  28 ELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLvSFSGVAIATSFAEVTGFCVLMGMAGALETLCGQTYGAEEFSEI 107
Cdd:cd13132    1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKL-ELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPISMLWIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQSMIFPMVFSSI 187
Cdd:cd13132   80 GVYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 188 AVLCLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCF 267
Cdd:cd13132  160 VALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 268 EMWSFELLTLFAGLLPnPQLQTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIV 347
Cdd:cd13132  240 EWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 348 SIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFLLGFV 427
Cdd:cd13132  319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 955306610 428 LHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQKEATK 465
Cdd:cd13132  399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 28-452 3.49e-49

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 174.22  E-value: 3.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  28 ELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAeVTGFCVLMGMAGALETLCGQTYGAEEFSEI 107
Cdd:cd13131    1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGA-DDLAAVALGSSLW-FPVFTFGMGLLLAVTPLVAQAHGAGDRRRI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPISMLWIFVDKILLLFGQDPEISHVAHEYCIY---SIPALYGFAVLQCqirYFQTQSMIFPMVF 184
Cdd:cd13131   79 RRAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLAlawGIPPALLFQVLRS---FLDALGRTRPAMV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 185 SSIAVLCLHVPICWALVFKL----ALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNA--LLSIPEFCQFA 258
Cdd:cd13131  156 ITLLALVLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRpdWARLKELLRLG 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 259 IPSGLMFCFEMWSFELLTLFAGllpnpQLQTSVLS---VCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRV 335
Cdd:cd13131  236 LPIGLTIFFEVSLFAAVALLMG-----RLGTTVLAahqIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 336 IVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYL 415
Cdd:cd13131  311 GLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWG 390

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 955306610 416 VGVPLAFLLGFVLHFNAKGLWMGSLTGSVLQVIILTV 452
Cdd:cd13131  391 IGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 38-379 1.94e-47

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 167.04  E-value: 1.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610   38 PMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIAtSFAEVTGFCVLMGMAGALETLCGQTYGAEEFSEIGNYTFCAIVT 117
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGP-VDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  118 LLLVCLPISMLWIFVDKILL-LFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQSMIFPMVFSSIAVLCLHVPI 196
Cdd:TIGR00797  79 ALLLGLPVLLVGYFFIDPLLsLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  197 CWALVFKL--ALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCFEMWSFEL 274
Cdd:TIGR00797 159 NYILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  275 LTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIVSIFFVCC 354
Cdd:TIGR00797 239 LALLVARLGSIAL--AAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316

                         330       340
                  ....*....|....*....|....*
gi 955306610  355 RHILGYAYSNDKEVVDYVSDIVPIL 379
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFV 341
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
29-452 4.44e-47

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 168.40  E-value: 4.44e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  29 LKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATS-FAEVTGFCVLMGMAGAleTLCGQTYGAEEFSEI 107
Cdd:COG0534    7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGT-AALAAVGLAFPiFFLLIALGIGLGVGGT--ALVAQALGAGDREEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPISML-WIFVDKILLLFGQDPEISHVAHEY---CIYSIPALYGFAVLQCQIRyfQTQSMIFPMV 183
Cdd:COG0534   84 RRVLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYlriILLGLPFLLLFNVLNGILR--GLGDTKTPMI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 184 FSSIAVLcLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGL 263
Cdd:COG0534  162 IMLIGNV-LNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 264 MFCFEMWSFELLTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVD 343
Cdd:COG0534  241 QQLAESLGFLVLNALVARLGTAAV--AAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 344 GVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFL 423
Cdd:COG0534  319 GLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYL 398

                        410       420
                 ....*....|....*....|....*....
gi 955306610 424 LGFvLHFNAKGLWMGSLTGSVLQVIILTV 452
Cdd:COG0534  399 LAF-LGLGLTGVWLALPIGEVLRALLLLL 426
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 30-460 1.20e-33

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 131.48  E-value: 1.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  30 KRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLVSfSGVAIATSFAEVTgFCVLMGMAGALETLCGQTYGAEEFSEIGN 109
Cdd:cd13137    1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAI-AAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 110 YTFCAIVTLLLVCLPISML-WIFVDKILLLFGQDPEISHVAHEYC---IYSIPALY----GFAVLQCqiryfqTQSMIFP 181
Cdd:cd13137   79 ALGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLrivLLGIPFFFlslvGNAALRG------AGDTKTP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 182 MVFSSIAVLcLHVPICWALVFKL----ALGHVGAAYAIGISywlNVIGLGIYMnFSPACEKTKIVFSFNALLSIPEFC-- 255
Cdd:cd13137  153 MYIMIIVNV-LNIVLDYVLIFGLwgfpGLGVAGAALATVIS---RVVGALLLL-FLLLRGRLPIKISFKGFRLDRKIIkk 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 256 --QFAIPSGLMFCFEMWSFELLTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIV 333
Cdd:cd13137  228 llRIGLPAGLEQLLRSLGFLVLLAIVASYGTAAL--AAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYG 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 334 RVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAY 413
Cdd:cd13137  306 KRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISM 385

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 955306610 414 YLVGVPLAFLLGFVLHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQ 460
Cdd:cd13137  386 WLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 36-453 7.42e-28

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 115.11  E-value: 7.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  36 AAPMVAANMCQYLLQVVSLMMVGHLGvLVSFSGVAIATSFAeVTGFCVLMGMAGALETLCGQTYGAEEFSEIGNYTFCAI 115
Cdd:cd12082    1 AAPLLLSMLLQTLYNLVDTFFLGRLL-GDALAAVGLAFPLI-ALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 116 VTLLLVCLPIS-MLWIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQ-TQSMIFPMVFSSIAVLcLH 193
Cdd:cd12082   79 VLAILLGLLLAaLLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQgEGDTRTAMIISVLSNL-LN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 194 VPICWALVF---KLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCFEMW 270
Cdd:cd12082  158 ILLDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 271 SFELLTLFAGLLPNPqLQTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIVSIF 350
Cdd:cd12082  238 GLLIIVAIVAAFGGA-AALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLL 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 351 FVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFLLGfVLHF 430
Cdd:cd12082  317 ILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLA-YLGL 395

                        410       420
                 ....*....|....*....|...
gi 955306610 431 NAKGLWMGSLTGSVLQVIILTVV 453
Cdd:cd12082  396 GLYGIWLALVISLILAALVLLLF 418
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 29-456 4.04e-27

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 113.01  E-value: 4.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  29 LKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAeVTGFCVLMGMAGALETLCGQTYGAEEFSEIG 108
Cdd:cd13133    4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSE-VALAASGPAGVLY-FAILMLFFGLSSGVQVFVAQYNGAGRYSRIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 109 NYTFCAIVTLLLVCLPISMLWIFVDK-ILLLFGQDPEISHVAHEYCIYSIPALyGFAVLQCQIRYF---QTQSMIfPMVF 184
Cdd:cd13133   82 RVLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGA-PFSLLGAALRAFfsgIGRTRV-VMVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 185 SSIAVLcLHVPICWALVF-KL---ALGHVGAAYAIGISYWLNVIGLGIYMnFSPACEK---TKIVFSFNALLsIPEFCQF 257
Cdd:cd13133  160 NLVMVV-VNIVLDYALIFgKLgfpAMGIAGAAIATVIAEAVSLLFFLLLL-FRRKNRRrfgLRRAWRFDREL-LRRILRL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 258 AIPSGLMFCFEMWSFELLTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIV 337
Cdd:cd13133  237 GLPSGLQFFLDVGAFTVFFLLIGRLGTTEL--AATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 338 IIGIVDGVIVSIFFVCCRHILGYAYSNDK---EVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYY 414
Cdd:cd13133  315 KLALAYMLLLGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAW 394

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 955306610 415 LVGVPLAFLLGfVLHFNAKGLWmgslTGSVLQVIILTVVTVL 456
Cdd:cd13133  395 LYLLPPAYLLV-VLGAGLAGAW----TVETVYVIVLALIFLL 431
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 28-442 2.33e-26

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 111.06  E-value: 2.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  28 ELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAeVTGFCVLMGMAGALETLCGQTYGAEEFSEI 107
Cdd:PRK01766  10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSA-TDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 108 GNYTFCAIVTLLLVCLPI-SMLWIFVDKILLLFGQDPEISHVAHEY---CIYSIPALYGFAVLQCQIRYF-QTQSMifpM 182
Cdd:PRK01766  88 AHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQVLRSFIDGLgKTKPT---M 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 183 VFSSIAVLcLHVPICWALVF-KL---ALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNA--LLSIPEFCQ 256
Cdd:PRK01766 165 VIGFLGLL-INIPLNYIFIYgKFgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKpdWAVIKRLLK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 257 FAIPSGLMFCFEMWSFELLTLFAGllpnpQLQTSVLS---VCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIV 333
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVS-----PLGTVTVAahqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 334 RVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVpILCGSFT-ADSLIGALSGIARGGGFQQIGAYVNLGA 412
Cdd:PRK01766 319 YIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLL-LFAALFQfSDAIQVIGSGALRGYKDTRVIFFITFIA 397

                        410       420       430
                 ....*....|....*....|....*....|
gi 955306610 413 YYLVGVPLAFLLGFVLHFNAKGLWMGSLTG 442
Cdd:PRK01766 398 YWVLGLPLGYILALTDPMGPFGFWIGLIIG 427
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 34-460 1.31e-24

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 105.62  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  34 SMAAPMVAANMCQYLLQVVSLMMVGHLGVLVSFSGVAIATSFAE-VTGFCvlMGMAGALETLCGQTYGAEEFSEIGNYtf 112
Cdd:cd13138    7 LFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFlLTAIG--MGLSMGGTILISQYIGAKDEEKAKKA-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 113 caIVTLLLVCLPIS-----MLWIFVDKILLLFGQDPEISHVAHEY---CIYSIPALYGFAVLQCQIRyfqtqSM---IFP 181
Cdd:cd13138   83 --VGTLLVLFLILGivltiLGLLFAPPILRLMNTPAEILELAVSYlriCFLGIPFIFGYNAYSAILR-----GLgdsKTP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 182 MVFSSIAVLcLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYM---NFSPACEKTKIVFSFNALLSIpefCQFA 258
Cdd:cd13138  156 LYFVIIACV-LNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLrkkKLPFKLSLKDFRFDKEILKEI---LKIG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 259 IPSGLMFCFEMWSFELLTLFA---GLLPnpqlqTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRV 335
Cdd:cd13138  232 LPSALQQSLVSISFLIINSIVnsyGVVA-----SAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRT 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 336 IVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYL 415
Cdd:cd13138  307 GIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWL 386

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 955306610 416 VGVPLAFLLGFVLHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQ 460
Cdd:cd13138  387 VRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
MatE pfam01554
MatE; The MatE domain
 38-198 1.39e-23

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 96.87  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610   38 PMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAEVTGFcVLMGMAGALETLCGQTYGAEEFSEIGNYTFCAIVT 117
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGA-VALAAVSIANSIASLIFM-FLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  118 LLLVCLPISML-WIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQS-MIFPMVFSSIAVLcLHVP 195
Cdd:pfam01554  79 GLLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGdTKPPMYINIISLL-LNIP 157


                  ...
gi 955306610  196 ICW 198
Cdd:pfam01554 158 LNY 160
MatE pfam01554
MatE; The MatE domain
 260-423 1.96e-15

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 73.75  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  260 PSGLMFCFEMWSFELLTLFAGLLPnpQLQTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVII 339
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  340 GIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAyYLVGVP 419
Cdd:pfam01554  79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157


                  ....
gi 955306610  420 LAFL 423
Cdd:pfam01554 158 LNYL 161
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 34-441 9.24e-15

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 76.00  E-value: 9.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  34 SMAAPMVAANMCQYLLQVVSLMMVGHLGVlVSFSGVAIATSFAEVtGFCVLMGMAGALETLCGQTYGAEEFSEIGNYTFC 113
Cdd:cd13134    7 ALAWPIFIELLLQMLLGTIDTFMLSRYSD-NAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 114 AIVTLLLVCLPIS-MLWIFVDKILLLFGQDPEISHVAHEYciysIPALYGFAVLQCqirYFQTQSMIF--------PMvF 184
Cdd:cd13134   85 ALLFNLLLGLVFSlLLLFFGAELLRLMGLPPELLALGSTY----LRIVGGSLFLQA---LSLTLSAILrshgrtkiPM-Y 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 185 SSIAVLCLHVPICWALVFKL----ALGHVGAAYAIGISYWLNVIGLGIYMNFspaceKTKIVFSFNALLSIP-----EFC 255
Cdd:cd13134  157 VSLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFR-----KLKIRFRLKDLRPFPkkllkKIL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 256 QFAIPSGL-MFCFEMwSFELLTLFAGLLPNPQLqtSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVR 334
Cdd:cd13134  232 KIGLPSAGeELSYNL-SQTVITAFIARLGTAAL--AARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVL 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 335 VIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSdivPILCGSF---TADSLIGALSGIARGGGFQQIGAYVNLG 411
Cdd:cd13134  309 KSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGK---TLLLISIllePGRAFNIVLIGSLRAAGDARFPVLIGII 385

                        410       420       430
                 ....*....|....*....|....*....|
gi 955306610 412 AYYLVGVPLAFLLGFVLHFNAKGLWMGSLT 441
Cdd:cd13134  386 SMWGISVPLAYLLGIVLGLGLLGVWIAFAA 415
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 36-461 2.83e-13

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 71.45  E-value: 2.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  36 AAPMVAANMCQYLLQVVSLMMVGHLG-VLVSfsgvAIATSFAEV-TGFCVLMGMAGALETLCGQTYGAEEFSEIGNYTFC 113
Cdd:cd13142   17 AWPIIVSNLLQVAYNLADTFWLGRLGaDAVA----APSISWPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 114 AIVTLLLVCLPISML-WIFVDKILLLF-GQDPEISHVAHEYC---IYSIPALYGFAVLQCQIR-YFQTqsmIFPMVFSSI 187
Cdd:cd13142   93 TFSFVIILSLILAVLgYILSRPLLLLLiGAPEEVYPLALAYLriiFLGLPFMFIFFVFNSLLRgIGDT---KTPMKIMFG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 188 AVLcLHV---PIcwaLVFKL----ALGHVGAAYAIGISYWLN-VIGLGI----YMNFSPACEKTKIVFSFnallsIPEFC 255
Cdd:cd13142  170 SVL-LNVildPL---LIFGIgpfpGLGVAGAALATVISRGIAaVIGLYLlfkgRVGLKISLRDLKPDWEW-----LKKIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 256 QFAIPSGLMFCFEMWSFELLTLFAGLLPnpqlqTSVLS---VCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGI 332
Cdd:cd13142  241 RIGLPSSIEQSARALGFTVMTALVAGFG-----TVVVAaygIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 333 VRVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGA 412
Cdd:cd13142  316 VKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILR 395

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 955306610 413 YYLVGVPLAFLLGFVLHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQK 461
Cdd:cd13142  396 LWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 34-449 4.57e-13

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 70.62  E-value: 4.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  34 SMAAPMVAANMCQYLLQVVSLMMVGHL-------GVLVSFSGVAIATSFAEVTGfcvlMGMAgaleTLCGQTYGAEEFSE 106
Cdd:cd13143    8 KFALPAIIGMLVNGLYNIVDGIFVGHGvgalalaAVNLVFPIIMLLMALGLMIG----VGGA----SLISRRLGAGDREK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 107 IGNY-TFCAIVTLLLVCLPISMLWIFVDKILLLFGQDPEISHVAHEY---CIYSIPALYGFAVLQCQIRYF-QTQSMIFP 181
Cdd:cd13143   80 ANRIfSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYlriILLGAPFTILSSVLNNLLRAEgKPKLAMLG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 182 MVFSSIAVLCLHvpicWALVFKLALGHVGAAYAIGISYwlnVIGLGIYMNF----SPACEKTKIVFSFNaLLSIPEFCQF 257
Cdd:cd13143  160 MLIGAVLNIILD----PLFIFVLGLGIAGAALATVIAQ---LISLLLLLLYffrgKSLLKLSLLRFKLS-LKIIKEILAL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 258 AIPSGLMFcfemwsfeLLTLFAGLLPNPQLQT-------SVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQ 330
Cdd:cd13143  232 GFPSFLMQ--------LSSSVVTIVLNLTLLGyggdigvAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVK 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 331 GIVRVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIargggFQQIG----- 405
Cdd:cd13143  304 QALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGY-----FQAIGkakra 378

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 955306610 406 AYVNLGAYYLVGVPLAFLLGFVlhFNAKGLWMGSLTGSVLQVII 449
Cdd:cd13143  379 ALLSLLRQGLFLIPLLLILPRL--FGLDGIWLAFPLAEILTLLL 420
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 30-452 3.14e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 65.01  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  30 KRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLvSFSGV-AIATSFAEVTGFCVlmGMAGALETLCGQTYGAEEFSEIG 108
Cdd:cd13135    1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIR-YYSAVgNVTTPFNTITGFLG--SISIGFTILGSQSVGAKDIKRIN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 109 NYTFCAIVTLLLVCLPISMLWIFVDKILL-LFGQDPEISHVAHEYC-IYSIPALYGFAVLQCQIrYFQTQSMIFPMVFSS 186
Cdd:cd13135   78 DYAISSIVYNSIIGVILFLLWLFGARIIFvLFGVDGQILGYSINYVrIFSIYLLLLGILFTFSS-ILQGIGETKPIMYGG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 187 IAVLCLHVPICWALVF-KL---ALGHVGAAYAIGISywlNVIGLGIYMNFspaCEKTKIV----FSFNALLSIPEFCQFA 258
Cdd:cd13135  157 IIKNLLNVILDYVLIFgNFgfpRLGIIGAAIATTIA---NVLNLIILVYL---CRKIKKLtfklSNTKVLKANIRPYKFT 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 259 IPSGL--MFCFEMWSFELLTLFAGLLPNPQLQTSVLSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIVRVI 336
Cdd:cd13135  231 IKLGLplGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNIC 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 337 VIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVsdiVPILCgsFTADSLIGALSGIARGGGFQQIGA-----YVNLG 411
Cdd:cd13135  311 LGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYS---IPYLI--FIIIILFFKSINIVYGFAIRAIGDtkwmlYTQII 385

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 955306610 412 AYYLVgVPLAFLLGFVLHFNAKGLWMGSLTGSVLQVIILTV 452
Cdd:cd13135  386 GTIIV-VSVALLLIFVFKLGLAGVYITLFIDEIIRAIINFL 425
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
27-438 4.17e-09

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 58.60  E-value: 4.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  27 VELKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLVSFSGVAIATSFAEVTGFCVlmGMAGALETLCGQTYGAEEFSE 106
Cdd:PRK00187   7 TELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCV--GVIAAVGTLVAIRHGAGDIEG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 107 IGNYTFCAI-VTLLLVCLPISMLWIfVDKILLLFGQDPEISHVAHEYCI---YSIPALYGFAVLqcqiRYF------QTQ 176
Cdd:PRK00187  85 ATRLAQAGLwLAWLLALVAALLLWN-LKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLSFMAL----RGFtsalgrAGP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 177 SMIFPMVFSSIAVLCLHVPI-CWALVFKLALGHVGAAYAIGISywLNVIGLGIYMNFSPACEKTKIV--FSFNALLSIPE 253
Cdd:PRK00187 160 VMVISLAGAVANLLLNYALIeGWFGLPKLGLMGIGLVTALVSN--GMALALALYIRRHPAYAAYPLRkgLSRPSRAALRE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 254 FCQFAIPSGLMFCFEMWSFELLTLFAGLLPNPQLQTSvlSVCLNTTTLHYIIPYAVGASASTRISNELGAGNPKAAQGIV 333
Cdd:PRK00187 238 LWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAH--QIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 334 RVIVIIGIVDGVIVSIFF-VCCRHILG-YAYSNDKEVVDYVSDIVPILCGSF-------TADSLIGALSGIARGGGFQQI 404
Cdd:PRK00187 316 RVGIGFGAVVMLLFAGLFwLLPEAIIGlFLDRNDPAFAEIVQLAVSLLAVAAwfelfdgTQTIAMGAIRGLKDARTTFLI 395

                        410       420       430
                 ....*....|....*....|....*....|....
gi 955306610 405 GayvnLGAYYLVGVPLAFLLGFVLHFNAKGLWMG 438
Cdd:PRK00187 396 G----LACYWLVGAPLAWLLAFTLGWGAVGVWWG 425
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 30-451 3.80e-07

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 52.18  E-value: 3.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  30 KRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLVSFSGVAIAT---SFAEVT-GFcVLMGMAGaletLCGQTYGAEEFS 105
Cdd:cd13136    3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTtifNTLFWLfGF-LRMGTTG----LVAQALGAGDRE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 106 EIGNytfcAIVTLLLVCLPISMLWI-----FVDKILLLFGQDPEISHVAHEYC---IYSIPALYGFAVLQCQIRYFQtQS 177
Cdd:cd13136   78 EAIA----LLVRALLLALAIGLLLIllqspLLALALLLLGASAAVAALARQYLrirILGAPAVLLNYVATGWFRGLQ-DT 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 178 MIfPMVFSsIAVLCLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSpacEKTKIVFSFNALLSIPEFCQF 257
Cdd:cd13136  153 RT-PLILQ-IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRR---VRLLGKSLSRRLPSKAALKRL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 258 AIPSGLMF----CFEMwSFELLTLFAGLLPNPQLqtSVLSVCLNtttLHYIIPYAVGA---SASTRISNELGAGNPKAAQ 330
Cdd:cd13136  228 FKLNRDIFirtlALLA-AFLFFTALAARLGDVIL--AANQILLQ---FWLLSSYFLDGfayAAEALVGRALGAGDRKAAR 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 331 GIVRVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNL 410
Cdd:cd13136  302 RVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSML 381

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 955306610 411 GAyYLVGVPLAFLLGFVLHFNakGLWMGSLTGSVLQVIILT 451
Cdd:cd13136  382 VS-LAVFLPLLFLLVPLWGNH--GLWLALILFMLLRGLTLA 419
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 29-210 4.73e-07

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 52.12  E-value: 4.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  29 LKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLVsfsgVAIATSFAEVTGFCVL--MGMAGALETLCGQTYGAEEFSE 106
Cdd:cd13134  227 LKKILKIGLPSAGEELSYNLSQTVITAFIARLGTAA----LAARTYASNISMFVFLfsLAIGQATQIIVGHLVGAGDFDE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 107 IGNYTFCAIVTLLLVCLPIS-MLWIFVDKILLLFGQDPEISHVAheyciysIPALYGFAVLQCqIRYFQTQSM------- 178
Cdd:cd13134  303 AYKRVLKSLKIGLLVSLAVAlLLALFREPILGLFTDDPEIIALG-------KTLLLISILLEP-GRAFNIVLIgslraag 374

                        170       180       190
                 ....*....|....*....|....*....|....
gi 955306610 179 --IFPMVFSSIAVLCLHVPICWALVFKLALGHVG 210
Cdd:cd13134  375 daRFPVLIGIISMWGISVPLAYLLGIVLGLGLLG 408
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 29-219 7.58e-05

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 44.81  E-value: 7.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  29 LKRVGSMAAPMVAANMCQYLLQVVSLMMVGHLGVLVsFSGVAIATSfAEVTGFCVLMGMAGALETLCGQTYGAEEFSEIG 108
Cdd:cd13137  225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAA-LAAYQIGLR-IESLAFMPGFGFSMAASTLVGQNLGAGDPDEAR 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 109 NYTF-CAIVTLLLVCLPISMLWIFVDKILLLFGQDPEISHVAHEYCIY---SIPALYGFAVLqcqiryfqtqSMIF---- 180
Cdd:cd13137  303 RYGKrALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIvalSQPFLAISFVL----------SGALrgag 372

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 955306610 181 ----PMVFSSIAVLCLHVPICWALVFKLALGHVGAAYAIGISY 219
Cdd:cd13137  373 dtrpPLIINLISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDT 415
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 35-445 1.26e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 41.23  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  35 MAAPMVAANMCQYLLQVVSLMMVGHLGVLVSFSGVAIATSFAEVTGFCVL-MGMAGALETLCGQTYGAEEFSEIGNYTFC 113
Cdd:cd13146   13 LALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGIGLVFPLGMIFLALgNGIQVGVSSLLARAIGAQRAKELDQAADS 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 114 AIVTLLLVCLPISML-WIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGFAVLQCQIRYFQTQSMIFPMVFSSIAVLCL 192
Cdd:cd13146   93 GLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 193 HVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNFSPACEKTKIVFSFNALLSIPEFCQFAIPSGLMFCFEMWSF 272
Cdd:cd13146  173 NIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQMLLQLISSISF 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 273 ELLTLFAGLLPNPQLQTSVLSVCLNTTTLhyIIPYAVGASASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIVSIFFV 352
Cdd:cd13146  253 LIYNRIIIDIDPVAMTAFTLVGRLDQFIL--IPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYV 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 353 CCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGALSGIARGGGFQQIGAYVNLGAYYLVGVPLAFLLGFVLHFNA 432
Cdd:cd13146  331 LVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGI 410

                        410
                 ....*....|...
gi 955306610 433 KGLWMGSLTGSVL 445
Cdd:cd13146  411 TGVYFGIVSANFF 423
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 313-461 1.40e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 41.06  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 313 ASTRISNELGAGNPKAAQGIVRVIVIIGIVDGVIVSIFFVCCRHILGYAYSNDKEVVDYVSDIVPILCGSFTADSLIGAL 392
Cdd:cd13139  298 AATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVL 377

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 955306610 393 SGIARGGGFQQIGAYVNLGAYYLVGVPLAFLLGFVLHFNAKGLWMGSLTGSVLQVIILTVVTVLTDWQK 461
Cdd:cd13139  378 SQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
MATE_MurJ_like cd13123
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 114-231 3.91e-03

MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240528 [Multi-domain]  Cd Length: 420  Bit Score: 39.36  E-value: 3.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 114 AIVTLLLVCLPISMLWIFVDK--ILLLFGQ---DPEISHVAHEYCIYSIPALYGFAVLQCQIR-YFQTQSMIFPMVFSSI 187
Cdd:cd13123  298 GLRLVLFLLLPAAVGLIVLAEpiVRLLFERgafTAEDTLMTASALAAYALGLPAFALVKLLSRaFYALKDTKTPVKIAVI 377

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 955306610 188 AVLcLHVPICWALVFKLalGHVGAAYAIGISYWLNVIGLGIYMN 231
Cdd:cd13123  378 AVA-VNILLNLLLIKPL--GHVGLALATSLSAWVNALLLLVLLR 418
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 85-232 4.66e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 39.50  E-value: 4.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610  85 MGMAGALETLCGQTYGAEEFSEIGNYTFCAIVTLLLVCLP-ISMLWIFVDKILLLFGQDPEISHVAHEYCIYSIPALYGF 163
Cdd:cd13145  287 IGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVaTVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAY 366

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955306610 164 AVLQCQIRYFQ-TQSMIFPMVFSSIAVLCLHVPICWALVFKLALGHVGAAYAIGISYWLNVIGLGIYMNF 232
Cdd:cd13145  367 VVLFISVSVLQgLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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