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Conserved domains on  [gi|942123136|ref|XP_014352806|]
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thyroid hormone receptor-associated protein 3 isoform X1 [Latimeria chalumnae]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
178-791 3.95e-135

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 420.34  E-value: 3.95e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  178 VKQHNAAQKEARASLPPAQVSQGAESKakppadatSNDSKDPEAiSKPWkgltaydsspkhpssvvhsvnasglnspphp 257
Cdd:pfam15440  55 MDDKKHGQKDPRISPHGNDHNRSYEHR--------SPDAKSSEA-SKSW------------------------------- 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  258 SPIQKSPLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPIPPlRTVPRQSPQAHSPKRSSPAERSPVRKSPPIISTSYN 337
Cdd:pfam15440  95 SPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY-QYSPKQQGRYHGRGRGSPKGGSPPRRSPADSFSFEG 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  338 NAQKEE------SRAGESTSPLVSSYLKRYLEEQKNKATTQDRENGREKDQKAKNEEREKVKERSGVSEMGV--PFFKSD 409
Cdd:pfam15440 174 KWHEDElrhqqsPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKEKEQKDARYEKREPARNSKWKDEHSlpPYQEKD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  410 YLAPKNESESLYRGIPSPRRYRYSNELEKSMSaefqeealhsmdmqESEKKHRVKGLKDSKLEDEPKCKSKvIVPSTAKN 489
Cdd:pfam15440 254 DQRNKGPQSSRYAERESPESYDYRHKFEKKLA--------------EFEKDFSDGRTEKYEKEDRKKFSSK-ISKGNRES 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  490 QDTYEERLSKWEELAYFPSAKEKSWEDE-----DMEDEVYPGR--AKREEVKRAELGGYRgpipdKNPRSGSYKVvhers 562
Cdd:pfam15440 319 DCFSEGRGRKTEEGQVEPSAKEKSKKDEiactdSMENDVYLERfnDKKEEKSKKEGDFRK-----EAELSSSSQH----- 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  563 psppprrsaeGKEREKMATKEENPpisKTTFSVYRGSEINVRMDALEDDF---GSSVAHERRLSRDLVHGNKKDLGFRSI 639
Cdd:pfam15440 389 ----------DDSREKPDVKESSP---KSVFSIKRESTVKVDMDKFDEDLarpSSSLAQERQLSRDLVHSGKKDQEFRSI 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  640 FQHIQSSQSRRSPSELFAQHIVTIVHHVKEHHFESPEMTLSERFTMYQRRAMEQGAARSKKSPEFHRRIDISPSAFRKHP 719
Cdd:pfam15440 456 FEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRAAEQEEMKSNKSPEIHRRIDMSPSALRKHR 535
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942123136  720 FLQDEMKGSRESSSykGEGKYKEDPVDLRLDIERRKKY--KERDHKRDGSRESVDSRDSSQSRERsTEKAQREH 791
Cdd:pfam15440 536 TLFEESKQSKESSY--KEGKVKEDPNDLRHDIERRRKErlKERDEKRFHIRDSQDSRFSSLSRER-TEKFQKPH 606
Btz super family cl09653
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
865-950 2.63e-03

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


The actual alignment was detected with superfamily member pfam09405:

Pssm-ID: 447763 [Multi-domain]  Cd Length: 121  Bit Score: 38.65  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  865 GKGRGWPRVMYPGNASSDFQRRNRDEEW-------DPEYTPKSKKYYLHDDREGEGGEKWANRGRGRGqfqRGRGRFLYR 937
Cdd:pfam09405   5 ESQSGRTPSAPPTEPKEDAERKRREHEKyekerdeNPAFVPTRGAFFLHDDRFAEPAANGFGKSKGRP---YGRRRRLWD 81
                          90
                  ....*....|...
gi 942123136  938 KSSDSpKWTHDKY 950
Cdd:pfam09405  82 DASEG-KWTHDLF 93
Cyano_gly_rpt TIGR04260
rSAM-associated Gly-rich repeat protein; Members of this protein family average 125 in length, ...
76-115 5.05e-03

rSAM-associated Gly-rich repeat protein; Members of this protein family average 125 in length, roughly half of which is the repetitive and extremely Gly-rich C-terminal region. Virtually all members occur in the Cyanobacteria, in a neighborhood that includes a radical SAM/SPASM domain, often a marker of peptide modification systems.


:

Pssm-ID: 275087 [Multi-domain]  Cd Length: 119  Bit Score: 37.80  E-value: 5.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 942123136   76 RGYNRGYRRPFFNRGRGRGF-HQRGQYNRGGYGNyRSNWQN 115
Cdd:TIGR04260  71 RGWGNGGGRGWGNGGGGGGWgNGGGGWGNGGWVN-GGGWRN 110
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
178-791 3.95e-135

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 420.34  E-value: 3.95e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  178 VKQHNAAQKEARASLPPAQVSQGAESKakppadatSNDSKDPEAiSKPWkgltaydsspkhpssvvhsvnasglnspphp 257
Cdd:pfam15440  55 MDDKKHGQKDPRISPHGNDHNRSYEHR--------SPDAKSSEA-SKSW------------------------------- 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  258 SPIQKSPLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPIPPlRTVPRQSPQAHSPKRSSPAERSPVRKSPPIISTSYN 337
Cdd:pfam15440  95 SPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY-QYSPKQQGRYHGRGRGSPKGGSPPRRSPADSFSFEG 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  338 NAQKEE------SRAGESTSPLVSSYLKRYLEEQKNKATTQDRENGREKDQKAKNEEREKVKERSGVSEMGV--PFFKSD 409
Cdd:pfam15440 174 KWHEDElrhqqsPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKEKEQKDARYEKREPARNSKWKDEHSlpPYQEKD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  410 YLAPKNESESLYRGIPSPRRYRYSNELEKSMSaefqeealhsmdmqESEKKHRVKGLKDSKLEDEPKCKSKvIVPSTAKN 489
Cdd:pfam15440 254 DQRNKGPQSSRYAERESPESYDYRHKFEKKLA--------------EFEKDFSDGRTEKYEKEDRKKFSSK-ISKGNRES 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  490 QDTYEERLSKWEELAYFPSAKEKSWEDE-----DMEDEVYPGR--AKREEVKRAELGGYRgpipdKNPRSGSYKVvhers 562
Cdd:pfam15440 319 DCFSEGRGRKTEEGQVEPSAKEKSKKDEiactdSMENDVYLERfnDKKEEKSKKEGDFRK-----EAELSSSSQH----- 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  563 psppprrsaeGKEREKMATKEENPpisKTTFSVYRGSEINVRMDALEDDF---GSSVAHERRLSRDLVHGNKKDLGFRSI 639
Cdd:pfam15440 389 ----------DDSREKPDVKESSP---KSVFSIKRESTVKVDMDKFDEDLarpSSSLAQERQLSRDLVHSGKKDQEFRSI 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  640 FQHIQSSQSRRSPSELFAQHIVTIVHHVKEHHFESPEMTLSERFTMYQRRAMEQGAARSKKSPEFHRRIDISPSAFRKHP 719
Cdd:pfam15440 456 FEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRAAEQEEMKSNKSPEIHRRIDMSPSALRKHR 535
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942123136  720 FLQDEMKGSRESSSykGEGKYKEDPVDLRLDIERRKKY--KERDHKRDGSRESVDSRDSSQSRERsTEKAQREH 791
Cdd:pfam15440 536 TLFEESKQSKESSY--KEGKVKEDPNDLRHDIERRRKErlKERDEKRFHIRDSQDSRFSSLSRER-TEKFQKPH 606
PHA03247 PHA03247
large tegument protein UL36; Provisional
183-344 7.37e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 7.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  183 AAQKEARASLPPAQVSQGAESKAKPPADATSNDSK-------DPEAISKPWKGLTAYDSSPKHPSSVVHSVNASGLNSPP 255
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESReslpspwDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  256 HPSPIQKSPLQ---SVA----VKRSPPQKSPQShSPAGPSSLR---------------------QSPVPPIPPLRTVPRQ 307
Cdd:PHA03247 2841 PPPGPPPPSLPlggSVApggdVRRRPPSRSPAA-KPAAPARPPvrrlarpavsrstesfalppdQPERPPQPQAPPPPQP 2919
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 942123136  308 SPQAHSPKRSSPAERSPVRKSPPIISTSYNNAQKEES 344
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
865-950 2.63e-03

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 38.65  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  865 GKGRGWPRVMYPGNASSDFQRRNRDEEW-------DPEYTPKSKKYYLHDDREGEGGEKWANRGRGRGqfqRGRGRFLYR 937
Cdd:pfam09405   5 ESQSGRTPSAPPTEPKEDAERKRREHEKyekerdeNPAFVPTRGAFFLHDDRFAEPAANGFGKSKGRP---YGRRRRLWD 81
                          90
                  ....*....|...
gi 942123136  938 KSSDSpKWTHDKY 950
Cdd:pfam09405  82 DASEG-KWTHDLF 93
Cyano_gly_rpt TIGR04260
rSAM-associated Gly-rich repeat protein; Members of this protein family average 125 in length, ...
76-115 5.05e-03

rSAM-associated Gly-rich repeat protein; Members of this protein family average 125 in length, roughly half of which is the repetitive and extremely Gly-rich C-terminal region. Virtually all members occur in the Cyanobacteria, in a neighborhood that includes a radical SAM/SPASM domain, often a marker of peptide modification systems.


Pssm-ID: 275087 [Multi-domain]  Cd Length: 119  Bit Score: 37.80  E-value: 5.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 942123136   76 RGYNRGYRRPFFNRGRGRGF-HQRGQYNRGGYGNyRSNWQN 115
Cdd:TIGR04260  71 RGWGNGGGRGWGNGGGGGGWgNGGGGWGNGGWVN-GGGWRN 110
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
178-791 3.95e-135

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 420.34  E-value: 3.95e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  178 VKQHNAAQKEARASLPPAQVSQGAESKakppadatSNDSKDPEAiSKPWkgltaydsspkhpssvvhsvnasglnspphp 257
Cdd:pfam15440  55 MDDKKHGQKDPRISPHGNDHNRSYEHR--------SPDAKSSEA-SKSW------------------------------- 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  258 SPIQKSPLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPIPPlRTVPRQSPQAHSPKRSSPAERSPVRKSPPIISTSYN 337
Cdd:pfam15440  95 SPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY-QYSPKQQGRYHGRGRGSPKGGSPPRRSPADSFSFEG 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  338 NAQKEE------SRAGESTSPLVSSYLKRYLEEQKNKATTQDRENGREKDQKAKNEEREKVKERSGVSEMGV--PFFKSD 409
Cdd:pfam15440 174 KWHEDElrhqqsPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKEKEQKDARYEKREPARNSKWKDEHSlpPYQEKD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  410 YLAPKNESESLYRGIPSPRRYRYSNELEKSMSaefqeealhsmdmqESEKKHRVKGLKDSKLEDEPKCKSKvIVPSTAKN 489
Cdd:pfam15440 254 DQRNKGPQSSRYAERESPESYDYRHKFEKKLA--------------EFEKDFSDGRTEKYEKEDRKKFSSK-ISKGNRES 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  490 QDTYEERLSKWEELAYFPSAKEKSWEDE-----DMEDEVYPGR--AKREEVKRAELGGYRgpipdKNPRSGSYKVvhers 562
Cdd:pfam15440 319 DCFSEGRGRKTEEGQVEPSAKEKSKKDEiactdSMENDVYLERfnDKKEEKSKKEGDFRK-----EAELSSSSQH----- 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  563 psppprrsaeGKEREKMATKEENPpisKTTFSVYRGSEINVRMDALEDDF---GSSVAHERRLSRDLVHGNKKDLGFRSI 639
Cdd:pfam15440 389 ----------DDSREKPDVKESSP---KSVFSIKRESTVKVDMDKFDEDLarpSSSLAQERQLSRDLVHSGKKDQEFRSI 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  640 FQHIQSSQSRRSPSELFAQHIVTIVHHVKEHHFESPEMTLSERFTMYQRRAMEQGAARSKKSPEFHRRIDISPSAFRKHP 719
Cdd:pfam15440 456 FEHIQSQQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRAAEQEEMKSNKSPEIHRRIDMSPSALRKHR 535
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942123136  720 FLQDEMKGSRESSSykGEGKYKEDPVDLRLDIERRKKY--KERDHKRDGSRESVDSRDSSQSRERsTEKAQREH 791
Cdd:pfam15440 536 TLFEESKQSKESSY--KEGKVKEDPNDLRHDIERRRKErlKERDEKRFHIRDSQDSRFSSLSRER-TEKFQKPH 606
PHA03247 PHA03247
large tegument protein UL36; Provisional
183-344 7.37e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 7.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  183 AAQKEARASLPPAQVSQGAESKAKPPADATSNDSK-------DPEAISKPWKGLTAYDSSPKHPSSVVHSVNASGLNSPP 255
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESReslpspwDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  256 HPSPIQKSPLQ---SVA----VKRSPPQKSPQShSPAGPSSLR---------------------QSPVPPIPPLRTVPRQ 307
Cdd:PHA03247 2841 PPPGPPPPSLPlggSVApggdVRRRPPSRSPAA-KPAAPARPPvrrlarpavsrstesfalppdQPERPPQPQAPPPPQP 2919
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 942123136  308 SPQAHSPKRSSPAERSPVRKSPPIISTSYNNAQKEES 344
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
190-395 9.02e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 9.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  190 ASLPPAQVSQGAESKAKPPADA---TSNDSKDPEAISKPWKGltAYDSSPKHPSSVVHSVNASGlnSPPHPSPIQKSPLQ 266
Cdd:pfam03154 410 AHPPPLQLMPQSQQLPPPPAQPpvlTQSQSLPPPAASHPPTS--GLHQVPSQSPFPQHPFVPGG--PPPITPPSGPPTST 485
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  267 SVAVKRSPPqksPQSHSPAGPSSLRQSPVPPIPPLRTVPRQSPQAHSPKRSSPAERSPvRKSPPIISTSYNNAQ-----K 341
Cdd:pfam03154 486 SSAMPGIQP---PSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSP-SPEPTVVNTPSHASQsarfyK 561
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 942123136  342 EESRAGESTS-------PLVSSYLKRYLEEQKNKATTQDRENGREKDQKAKNEEREKVKER 395
Cdd:pfam03154 562 HLDRGYNSCArtdlyfmPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKERERER 622
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
188-330 3.13e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 188 ARASLPPAQVSQGAESKAKPPADATSNDSKDPEAiskPWKGLTAYDSSPKHPSSVVHSVNASGLNSPPHPSPIQKSPLQS 267
Cdd:PRK07764 637 AEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP---AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ 713
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942123136 268 VAVKRSPPQKSPQSHSPAGPSSLRQSPVPPIPPLRTVPRQSPQAHSPKRSSPAERSPVRKSPP 330
Cdd:PRK07764 714 ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
182-352 3.76e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 3.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  182 NAAQKEARASLPPA-QVSQGAESKAKPPADATSNDSK---DPEAISKPWKGLTAYDSSPKHPSSVV--HSVNASGLNSPP 255
Cdd:pfam03154 160 SSAQQQILQTQPPVlQAQSGAASPPSPPPPGTTQAATagpTPSAPSVPPQGSPATSQPPNQTQSTAapHTLIQQTPTLHP 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  256 HPSPIQKSPLQSVAVKRSPPQKSPQSHspagPSSLRQSPVPPIP-PLRTVPRQSPQAHSPKRSSPAERSPVRKSPPIIST 334
Cdd:pfam03154 240 QRLPSPHPPLQPMTQPPPPSQVSPQPL----PQPSLHGQMPPMPhSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSP 315
                         170       180
                  ....*....|....*....|
gi 942123136  335 --SYNNAQKEESRAGESTSP 352
Cdd:pfam03154 316 aaPGQSQQRIHTPPSQSQLQ 335
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
180-552 1.00e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.22  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 180 QHNAAQKEARASLPPAQVSQGAESKAKPPADATSNDS----KDPEAISKPWKGLTAYDSSPKHPSSV-VHSVNASGLNSP 254
Cdd:PTZ00449 506 KHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEpkegGKPGETKEGEVGKKPGPAKEHKPSKIpTLSKKPEFPKDP 585
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 255 PHP----SPIQ-KSPLQSVAVKRSPPQKSPQS----HSPAGPSSLRQSPVPPIPPLRTVPRQSPQAHSPKRSSPAERSPV 325
Cdd:PTZ00449 586 KHPkdpeEPKKpKRPRSAQRPTRPKSPKLPELldipKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKP 665
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 326 RKSPPIISTSYNNAQKEESRAGESTSPLV-----SSYLKRYLEEQKNKATTQDRE--NGREKDQKAKNEE-REKVKERSG 397
Cdd:PTZ00449 666 PFDPKFKEKFYDDYLDAAAKSKETKTTVVldesfESILKETLPETPGTPFTTPRPlpPKLPRDEEFPFEPiGDPDAEQPD 745
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 398 VSEMGVP------FFK--------SDYLAPKNESESLYRGIPSP----RRYRYSNELEKSMSAEFQeealhSMDMqeseK 459
Cdd:PTZ00449 746 DIEFFTPpeeertFFHetpadtplPDILAEEFKEEDIHAETGEPdeamKRPDSPSEHEDKPPGDHP-----SLPK----K 816
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 460 KHRVKGLK--DSKLEDEPK--CKSKVIVPSTAKNQDTYEERLSKWEELAYFPSAKEKSWEDEDME---DEVYPGRAK-RE 531
Cdd:PTZ00449 817 RHRLDGLAlsTTDLESDAGriAKDASGKIVKLKRSKSFDDLTTVEEAEEMGAEARKIVVDDDGTEaddEDTHPPEEKhKS 896
                        410       420
                 ....*....|....*....|...
gi 942123136 532 EVKRaelggyRGP--IPDKNPRS 552
Cdd:PTZ00449 897 EVRR------RRPpkKPSKPKKP 913
PHA03247 PHA03247
large tegument protein UL36; Provisional
178-352 1.60e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  178 VKQHNAAQKEARASLPPAQvSQGAESKAKPPADATSNDSKDPEAISKPWKG--LTAYDSSPKHPSSVVHSVNASGLNSPP 255
Cdd:PHA03247 2661 VSRPRRARRLGRAAQASSP-PQRPRRRAARPTVGSLTSLADPPPPPPTPEPapHALVSATPLPPGPAAARQASPALPAAP 2739
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  256 HPSPIQKSPLQSVAVKRSPpqkSPQShsPAGPSSLRQSPVPPIPPLRTVPRqsPQAHSPKRSSPAERSPVRKSPPIISTS 335
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPA---RPPT--TAGPPAPAPPAAPAAGPPRRLTR--PAVASLSESRESLPSPWDPADPPAAVL 2812
                         170
                  ....*....|....*..
gi 942123136  336 YNNAQKEESRAGESTSP 352
Cdd:PHA03247 2813 APAAALPPAASPAGPLP 2829
PHA03247 PHA03247
large tegument protein UL36; Provisional
179-428 2.78e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  179 KQHNAAQKEARASLPPAQVSQGAESKAKPPADATSNDSKDPEAISKPWKGltaydSSPKHPSSVVHSVNASGLNSPPHPS 258
Cdd:PHA03247 2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG-----PPRRLTRPAVASLSESRESLPSPWD 2803
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  259 PIQKSPLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPIPPLRT-------------VPRQSPQAHSPKRSSPAERSPV 325
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplggsvapggdVRRRPPSRSPAAKPAAPARPPV 2883
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  326 RK--SPPIISTSYNNAQKEESRAGESTSPLVSSYLKRYLEEQKNKATTQDRENGREKDQKAKNEEREKVKERSGvsemGV 403
Cdd:PHA03247 2884 RRlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG----AV 2959
                         250       260
                  ....*....|....*....|....*
gi 942123136  404 PFFKSDYLAPkNESESLYRGIPSPR 428
Cdd:PHA03247 2960 PQPWLGALVP-GRVAVPRFRVPQPA 2983
PHA03378 PHA03378
EBNA-3B; Provisional
188-330 4.32e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.29  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 188 ARASLPPaqvsQGAESKAKPPADAtsndskdPEAISKPWKGLTAYDSSPKHPSSVVHSVNASGLNSPPHPSPIQKSPLQS 267
Cdd:PHA03378 681 ANTMLPI----QWAPGTMQPPPRA-------PTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAA 749
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942123136 268 VAVKRSPPQKSPQSHSPAGPSSLRQSPVPPiPPLRTVPRQSPQ-AHSPKRSSPAERSPVRKSPP 330
Cdd:PHA03378 750 APGRARPPAAAPGRARPPAAAPGAPTPQPP-PQAPPAPQQRPRgAPTPQPPPQAGPTSMQLMPR 812
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
187-330 4.51e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 4.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  187 EARASLPPAQVSQGAESKAKPPADAtsNDSKDPEAISKPWKGLTaydSSPKHPSSvvhSVNASGLNSPPHPSPIQKSPLQ 266
Cdd:PHA03307   57 AGAAACDRFEPPTGPPPGPGTEAPA--NESRSTPTWSLSTLAPA---SPAREGSP---TPPGPSSPDPPPPTPPPASPPP 128
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 942123136  267 SVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPI--------PPLRTVPRQSPQAHSPKRSSPAERSPVRKSPP 330
Cdd:PHA03307  129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAavasdaasSRQAALPLSSPEETARAPSSPPAEPPPSTPPA 200
PHA03378 PHA03378
EBNA-3B; Provisional
232-329 5.72e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 5.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 232 YDSSPKHPSSVVHSVNASGLNSPPHPSPIQKSPLQSVAVKRSPPQKSPQSHSP--AGPSSLRQ---SPVPPIPPLRTVPR 306
Cdd:PHA03378 674 YQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPpaAAPGRARPpaaAPGRARPPAAAPGR 753
                         90       100
                 ....*....|....*....|...
gi 942123136 307 QSPQAHSPKRSSPAERSPVRKSP 329
Cdd:PHA03378 754 ARPPAAAPGRARPPAAAPGAPTP 776
CytochromB561_N pfam09786
Cytochrome B561, N terminal; Members of this family are found in the N terminal region of ...
233-370 5.80e-04

Cytochrome B561, N terminal; Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterized proteins.


Pssm-ID: 462899  Cd Length: 579  Bit Score: 43.66  E-value: 5.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  233 DSSPKHPSSVVHSVNASGLNSPPHPSPIQKSPLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPV-----PPIPPLRTVPRQ 307
Cdd:pfam09786 124 THRKKPPKSKSSPQSPSPVLVPLHQSVSPSSSESRKGGDKSPAGSGKKLRSFSTSSKSPASPSvylrgSPVPLNSSPLPS 203
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942123136  308 SPQAHSPKRSSPaERSPVRKSPpiiSTSYNNAQKEESRAGEStsplvssyLKRYLEEQKNKAT 370
Cdd:pfam09786 204 DRNYENSVQSSP-EIDSAVSTP---WSRKRATIGKEIRTEKM--------LERFLAEVDEKIT 254
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
246-329 1.23e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 42.69  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  246 VNASGLNSPPH---PSPIQKSPLQSVAVKRS-PPQKSPQSHSPAGPSSLRQSPVP--PIPPLRTVPRQSPQahsPKRSSP 319
Cdd:pfam09606 362 ANPMQRGQPGMmssPSPVPGQQVRQVTPNQFmRQSPQPSVPSPQGPGSQPPQSHPggMIPSPALIPSPSPQ---MSQQPA 438
                          90
                  ....*....|
gi 942123136  320 AERSPVRKSP 329
Cdd:pfam09606 439 QQRTIGQDSP 448
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
246-330 1.85e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 246 VNASGLNSPPHPSPIQKSPLQS----VAVKRSPPQKSPQshspagPSSLRQSPVPPIPPLRTVPRQSPQAH-SPKRSSPA 320
Cdd:PRK14950 365 APQPAKPTAAAPSPVRPTPAPStrpkAAAAANIPPKEPV------RETATPPPVPPRPVAPPVPHTPESAPkLTRAAIPV 438
                         90
                 ....*....|
gi 942123136 321 ERSPVRKSPP 330
Cdd:PRK14950 439 DEKPKYTPPA 448
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
193-381 2.37e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  193 PPAQVSQGAESKAKPPADATSNDSKDPEAISKPWKGLTAYDSSPKHPSSVVHSVNASGLNSPPHPSPIQKSPLQSVAVKR 272
Cdd:PHA03307  232 AGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS 311
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  273 SPPQKSPQSHSPAGPSSLRQSPVPPIPPLRTVPRQSPQAHSPKRSSPAER-SPVRKSPPIISTSYNNAQKEESRAGESTS 351
Cdd:PHA03307  312 PRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADpSSPRKRPRPSRAPSSPAASAGRPTRRRAR 391
                         170       180       190
                  ....*....|....*....|....*....|
gi 942123136  352 PLVSSylkRYLEEQKNKATTQDRENGREKD 381
Cdd:PHA03307  392 AAVAG---RARRRDATGRFPAGRPRPSPLD 418
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
865-950 2.63e-03

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 38.65  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  865 GKGRGWPRVMYPGNASSDFQRRNRDEEW-------DPEYTPKSKKYYLHDDREGEGGEKWANRGRGRGqfqRGRGRFLYR 937
Cdd:pfam09405   5 ESQSGRTPSAPPTEPKEDAERKRREHEKyekerdeNPAFVPTRGAFFLHDDRFAEPAANGFGKSKGRP---YGRRRRLWD 81
                          90
                  ....*....|...
gi 942123136  938 KSSDSpKWTHDKY 950
Cdd:pfam09405  82 DASEG-KWTHDLF 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
192-339 3.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136  192 LPPAQVSQGAESKAKPPADAtsndskdPEAISKPWKGLTAYDSSPKHPSSVVHSVNASGlnSPPHPSPIQKSPLQSVAVK 271
Cdd:PHA03247 2555 LPPAAPPAAPDRSVPPPRPA-------PRPSEPAVTSRARRPDAPPQSARPRAPVDDRG--DPRGPAPPSPLPPDTHAPD 2625
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942123136  272 RSPPQKSPQSHSPAGPSSLRQSPVP-----PIPPLRTVPRQ-SPQAHSPKRSSPAERSPVRKSPPIISTSYNNA 339
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPErprddPAPGRVSRPRRaRRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699
PHA03378 PHA03378
EBNA-3B; Provisional
194-330 4.49e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 194 PAQVSQGAESKAKPPADAtsndskDPEAISKPWKGLTAYD-------------SSPKHPSSVVHSVNASGLNSPPH---- 256
Cdd:PHA03378 602 PSQTPEPPTTQSHIPETS------APRQWPMPLRPIPMRPlrmqpitfnvlvfPTPHQPPQVEITPYKPTWTQIGHipyq 675
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 257 PSPIQKS---PLQSVAVKRSPPQKSPQSHSP-AGPSSLRQSP----VPPIPPLRTVPRQSPQAHSPKRSSPAERSPVRKS 328
Cdd:PHA03378 676 PSPTGANtmlPIQWAPGTMQPPPRAPTPMRPpAAPPGRAQRPaaatGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 755

                 ..
gi 942123136 329 PP 330
Cdd:PHA03378 756 PP 757
Cyano_gly_rpt TIGR04260
rSAM-associated Gly-rich repeat protein; Members of this protein family average 125 in length, ...
76-115 5.05e-03

rSAM-associated Gly-rich repeat protein; Members of this protein family average 125 in length, roughly half of which is the repetitive and extremely Gly-rich C-terminal region. Virtually all members occur in the Cyanobacteria, in a neighborhood that includes a radical SAM/SPASM domain, often a marker of peptide modification systems.


Pssm-ID: 275087 [Multi-domain]  Cd Length: 119  Bit Score: 37.80  E-value: 5.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 942123136   76 RGYNRGYRRPFFNRGRGRGF-HQRGQYNRGGYGNyRSNWQN 115
Cdd:TIGR04260  71 RGWGNGGGRGWGNGGGGGGWgNGGGGWGNGGWVN-GGGWRN 110
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
238-354 6.00e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.62  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942123136 238 HPSSVVHSVNASGLNSPPHPSPiQKSPLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPIPPLRTVPRQ---------- 307
Cdd:PRK07994 360 HPAAPLPEPEVPPQSAAPAASA-QATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQlqraqgatka 438
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 942123136 308 ---SPQAHSPKRSSPAERSPVRKSPPIISTSYNNAQKEESRAGESTSPLV 354
Cdd:PRK07994 439 kksEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVE 488
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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