|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
26-454 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 633.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 26 VYVVFISLIIDLLAFTMILPLLPSLLDYYGHHDEGGLYHVLLQYVHSLRSLIGAPDTPRWNSVLFGGLIGSLFSLLQFLA 105
Cdd:cd17389 1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISSVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 106 SPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPQTRGKGMALIGIA 185
Cdd:cd17389 81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 186 FSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAVINVVFVYACFKETLPQekrahsvgsklqeaydliqpvslfk 265
Cdd:cd17389 161 FSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFALVLALADLLFIFFFLPETLPS------------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 266 fsavhhakksdldQMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIVQGGYVRRIKPGKEKK 345
Cdd:cd17389 216 -------------NLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKK 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 346 VALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASI 425
Cdd:cd17389 283 AVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACT 362
|
410 420
....*....|....*....|....*....
gi 919024404 426 VYWSLGSTACYSIGGVLLVAPLLILRKLD 454
Cdd:cd17389 363 VYWLAGSEACYTIGALLFLLPLLLLARLK 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
29-452 |
5.01e-66 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 215.52 E-value: 5.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 29 VFISLIIDLLAFTMILPLLPSLLdyYGHHDEGglyhvllqyvhslrsligapdtprwNSVLFGGLIGSLFSLLQFLASPM 108
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYV--REFNKLG-------------------------ASGYYVGLLQSSYSLGQFLASPL 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 109 IGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPQTRGKGMALIGIAFSV 188
Cdd:cd17330 54 WGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGL 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 189 GFLIGPLIGAYFAKQVRehegmfFVAPALFALTLAVINVVFVYACfketlpqekrahsvgsklqeaydliqpvslfkfsa 268
Cdd:cd17330 134 GFILGPALGGFLSTPYG------YALPFLVAAALALLNLVLVLFF----------------------------------- 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 269 vhhakksdLDQMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIVQGGYVRRIKP-GKEKKVA 347
Cdd:cd17330 173 --------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERKLL 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 348 LMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASIVY 427
Cdd:cd17330 245 RLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY 324
|
410 420
....*....|....*....|....*
gi 919024404 428 WSLGSTACYSIGGVLLVAPLLILRK 452
Cdd:cd17330 325 SFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
28-451 |
1.43e-45 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 162.81 E-value: 1.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 28 VVFISLIIDLLAFTMILPLLPSLLDYYGHHDEGGLYHvllqyvhslrsligapdtprwnsvlfGGLIGSLFSLLQFLASP 107
Cdd:cd17388 3 FILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATH--------------------------YGVLLALYALMQFIFAP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 108 MIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPQTRGKGMALIGIAFS 187
Cdd:cd17388 57 ILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 188 VGFLIGPLIGAYFAkQVREHegmffvAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSKLqeaydliQPVSLFKFS 267
Cdd:cd17388 137 LGFIAGPALGGLLG-EISPR------APFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRA-------NPFGSLRWL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 268 AVHHAkksdldqMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIVQGGYVRRIKPG-KEKKV 346
Cdd:cd17388 203 TGFPG-------LLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRlGEKRA 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 347 ALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATvVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASIV 426
Cdd:cd17388 276 ILLGLAADALGFLLLAFATQGWMVFPILILLALGGIA-GPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGI 354
|
410 420
....*....|....*....|....*...
gi 919024404 427 Y-WSLG--STACYSIGGVLLVAPLLILR 451
Cdd:cd17388 355 FaASPAtwPGLAWIIGAALYLICLVLAY 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
29-453 |
9.06e-40 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 146.95 E-value: 9.06e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 29 VFISLIIDLLAFTMILPLLPslldyyghhdegglyhvllQYVHSLrsliGApdtprwnSVLFGGLIGSLFSLLQFLASPM 108
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILP-------------------LYAESL----GA-------SVAQIGLIVAAYALAQLLFSPP 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 109 IGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDISTPQTRGKGMALIGIAFS 187
Cdd:cd17325 51 AGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIG 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 188 VGFLIGPLIGAYFAKQvrehegMFFVAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSKLQEAYDLIQPVSLFKFs 267
Cdd:cd17325 131 LGFLIGPLLGGLLADA------LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLA- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 268 avhhakksdldqmqrIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIVQGGYVRRIKPGKEKKVA 347
Cdd:cd17325 204 ---------------LFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 348 LMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASIVY 427
Cdd:cd17325 269 LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
410 420
....*....|....*....|....*..
gi 919024404 428 WSLG-STACYSIGGVLLVAPLLILRKL 453
Cdd:cd17325 349 DAFGfATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
29-453 |
2.85e-39 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 145.06 E-value: 2.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 29 VFISLIIDLLAFTMILPLLPslldyyghhdegglyhvllqyvHSLRSLIGAPDTPrwnsvlfgGLIGSLFSLLQFLASPM 108
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLS----------------------THIRSLGASPTVI--------GLIGSVYGALQLFSSPL 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 109 IGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPQTRGKGMALIGIAFSV 188
Cdd:cd17390 51 VGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 189 GFLIGPLIGAYFAkqvrEHEGMFFVaPALFALTLAVINVVFVYACFKetlpqekrahsvgsklqEAYDLIqpvsLFKFsa 268
Cdd:cd17390 131 GFILGPVVGGHLA----ETDGGFYY-VALLCSAIFILNAGLVWFLLS-----------------KLWDLL----LVRF-- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 269 vhhakksdldqmqrigLVYFLYLFLYSGleFTLTFLthNRFQYDSMKQGKMFFFIGIIMSIVQG--GYVRRIKPGKEKKV 346
Cdd:cd17390 183 ----------------LMGFSVLLFRSN--FSLYLE--ERFDLSPKTIGYLISYSGVLGALSGFlvGRILKLYKNNEYLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 347 ALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASIV 426
Cdd:cd17390 243 LLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLL 322
|
410 420
....*....|....*....|....*..
gi 919024404 427 YwSLGSTACYSIGGVLLVAPLLILRKL 453
Cdd:cd17390 323 Q-EFSVSGPGLLGAVLALAAILLMLAR 348
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-418 |
1.12e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.93 E-value: 1.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 24 KMVYVVFISLIIDLLAFTMILPLLPSLLDYYGHhdegglyhvllqyvhslrsligapdtprwnSVLFGGLIGSLFSLLQF 103
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGA------------------------------SPAQAGLVVTAYLLGAA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 104 LASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDISTPQTRGKGMALI 182
Cdd:COG2814 60 LGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 183 GIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPalfaltLAVINVVFVYACFKETLPQEKRAHSVGSKlqeaydliqpvS 262
Cdd:COG2814 140 GAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV------LALLALLLLLRLLPESRPAARARLRGSLR-----------E 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 263 LFKFSAVhhakksdldqmQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIVQGGYVRRIKPGK 342
Cdd:COG2814 203 LLRRPRL-----------LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 919024404 343 EKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARAL 418
Cdd:COG2814 272 RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
87-420 |
5.84e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.67 E-value: 5.84e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAI 165
Cdd:pfam07690 30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 166 VTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKqvrehegmFFVAPALFALTLAVINVVFVYACFKETLPQEKRAH 245
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS--------LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 246 SVGSKLQEAYDLIQPVSLfkfsavhhakksdlDQMQRIGLVYFLYLFLYSGLeFTLTFLTHNRFQYDSMKQGKMFF---F 322
Cdd:pfam07690 182 PAEEARLSLIVAWKALLR--------------DPVLWLLLALLLFGFAFFGL-LTYLPLYQEVLGLSALLAGLLLGlggL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 323 IGIIMSIVQGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKG 402
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERG 326
|
330
....*....|....*...
gi 919024404 403 TVMGIFRSLGALARALGP 420
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
92-453 |
1.92e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 112.66 E-value: 1.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGI-SKGNISLSTAIVTDIS 170
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQvreHEGMFFVAPALFALTLAVINVVFVYacfketlPQEKRAhsvgsk 250
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI---SWRYPFFLLAALIPVAFLAILFLLP-------EPKEKA------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 lqeaydliQPVSLFKFSAVHHAKKSDLdqMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIV 330
Cdd:cd17474 181 --------KSSSATKLRDLKKALRGRG--LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 331 QGGYVRRIKPGKEKKvALMGIGLVI--PSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIF 408
Cdd:cd17474 251 SLFVGRLLKKRFGAR-RILVIGLLLyaLSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 919024404 409 RSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLILRKL 453
Cdd:cd17474 330 NFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
26-448 |
2.15e-26 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 110.00 E-value: 2.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 26 VYVVFISLIIDLLAFTMILPLLPSLldyyghhdegglyhvllqyvhsLRSLIGapdtprwNSVLFGGLIgSLFSLLQFLA 105
Cdd:cd17331 2 LLIVHLNIVLYATCYWLQQPVLPYL----------------------TKKLGV-------DSVVFGYLQ-TTFSVLQLVG 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 106 SPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVgGISKGNISLSTAIVTDISTPQTRGKGMALIGIA 185
Cdd:cd17331 52 GPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLP-SVFMHAMQAAQMVVTDLTDPGERAAALGRLGLS 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 186 FSVGFLIGPLIGAYFAKQVREHegmffvAPALFALTLAVINVVFVYACF-KETLPQEKRAHSVGSKLQEAYDLIQPVSLF 264
Cdd:cd17331 131 YGIGMVVGSFLGGLLTKKFGEQ------AAALVAAVGSLLSIVLVILLIpSNTKSKREKEAKESASPPSVFNLKEILRLL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 265 KFSAVhhakksdldqmQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIVQGGYVRR-IKPGKE 343
Cdd:cd17331 205 RLPGV-----------AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPlTKRFGE 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 344 KKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAA 423
Cdd:cd17331 274 RSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIG 353
|
410 420 430
....*....|....*....|....*....|
gi 919024404 424 SIVY-----WSLGSTaCYSIGGVLLVAPLL 448
Cdd:cd17331 354 GALLqaygfPSFGLL-GAAINGLLTVYLLL 382
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
92-454 |
8.92e-25 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 105.00 E-value: 8.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDIS 170
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQvrehegmFFVAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSK 250
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-------SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEIL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 lqeaydlIQPVSLFKFSAVhhakksdldqmQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIV 330
Cdd:cd17329 191 -------RGYKIVLRDRAF-----------LLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 331 QGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRS 410
Cdd:cd17329 253 QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 919024404 411 LGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLILRKLD 454
Cdd:cd17329 333 AWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
92-449 |
4.73e-22 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 97.28 E-value: 4.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-AIVTDIS 170
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAaTLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVRehegmfFVAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSK 250
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG------FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 LQeayDLIQPVSLfkfsavhhakksdldqmqRIGLVYFLYLFLYSGLEFTLTFLTHNRFqydsMKQGKMFFFIGIIMSIV 330
Cdd:cd17489 188 FR---RLVEKKVL------------------PPALILFLASIAYGAISTFLPLYAAERG----ISNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 331 QGGYVRRIKPGK-EKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFR 409
Cdd:cd17489 243 SRPFSGKLSDRKgPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFF 322
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 919024404 410 SLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLI 449
Cdd:cd17489 323 IFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
92-449 |
1.69e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 95.69 E-value: 1.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAIVTDIS 170
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHegMFFVAPALFALTLAVINVVFvyacfketLPQEKRAHsvgsk 250
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWR--AAFLAIAVLALLAALLLWRL--------LPSLPPKK----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 lqeaydliqPVSLFKFSAVHHAKKSdlDQMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIG---IIM 327
Cdd:cd17324 182 ---------PGSLGLLSSLLLLLRN--PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGvagVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 328 SIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDqKGTVMGI 407
Cdd:cd17324 251 SPLAGRLADRGGR---RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 919024404 408 FRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLI 449
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
92-450 |
2.27e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.49 E-value: 2.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-AIVTDIS 170
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEGMFFVAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSK 250
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILA----SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 lqeAYDLIQPVSLFKFSAVhhakksdldqmQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKM---FFFIGIIM 327
Cdd:cd06174 190 ---KSVLKLLKRVLKNPGL-----------WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLlslFGLAGALG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 328 SIVQGGYVRRIKPgkEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGI 407
Cdd:cd06174 256 SLLLGLLSDRLIG--RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 919024404 408 FRSLGALARALGP-MAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd06174 334 LNTFGFLGGAIGPlLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
90-450 |
2.61e-20 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 92.27 E-value: 2.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 90 FGGLIGSLFSLLQFLASPMIGAASDYYG--RKPLMLLNLIGIaVSYAIWAVSTNFTIFV-----LARIVGGISKGNISLS 162
Cdd:cd17326 37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIVSILIAI-VGNILYALAEYFPSNRkyvmlVARFLIGVGAGNVAVL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 163 TAIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAK---QVREHEGMFFV----APALFALTLAVINVVFVYACFK 235
Cdd:cd17326 116 RAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPigyPGYVIGIKLRFnmytAPAWLMAILGIINIILILFFFK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 236 ETlpqekrahsvgsklqeaydliqpVSLFkfsavhhakksdldqmqriglVYFLYLFLYSGLEFTLTFLTHNRFQYDS-- 313
Cdd:cd17326 196 EV-----------------------VCIF---------------------LFFVVLFIFANLETIGTPLTMDMYGWTRee 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 314 -MKQGKMFFFIGIIMSIVQGGYVRRIKPGKEKKVALMGIGLVIpsfLVIGLASTTTVMYCGLALFSFASATVVPCLTTLM 392
Cdd:cd17326 232 aVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLIL---FFLGFVVTLPWGITGVILFGLGYPIGNVMLYTLY 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 919024404 393 SSYGQDDQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17326 309 SKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
92-450 |
1.48e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.85 E-value: 1.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDIS 170
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEG--MFFVAPALFALTLAVINVVFvyacfketlpqekrahsvg 248
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLL----AAFGwrAAFLILGLPGLLLALLRFWL------------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 249 sklqeaydliqpvslfkfsavhhakksdldqmqrIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGK---MFFFIGI 325
Cdd:COG2271 185 ----------------------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLllsLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 326 IMSIVQGGYVRRIKPGKeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVM 405
Cdd:COG2271 231 VGSLLGGWLSDRLGRRR-KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTAS 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 919024404 406 GIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:COG2271 310 GLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
86-428 |
2.85e-17 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 83.62 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 86 NSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLAriVGGISKGNISLSTAI 165
Cdd:cd17387 33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VSGIFSVTFSVIFAY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 166 VTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEGMFFVapALFALTLAVINVVFVYACFKETLPQEKRAH 245
Cdd:cd17387 111 VADITTEEERSTAYGLVSATFAASLVTSPALGAYLS----ESYGDNLV--VLVATIVALLDICFILLAVPESLPEKMRPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 246 SVGSKLQ-EAYDLiqpvslfkFSAVHHAKKSDLDQMqrIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIG 324
Cdd:cd17387 185 SWGAPISwEQADP--------FASLRKVGKDKTVLL--ICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 325 IIMSIVQG--GYVRRIKPGKeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATvVPCLTTLMSSYGQDDQKG 402
Cdd:cd17387 255 ILSITAQTllLSILMRSIGA-KNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSIT-FPAISALVSRYADPDQQG 332
|
330 340
....*....|....*....|....*.
gi 919024404 403 TVMGIFRSLGALARALGPMAASIVYW 428
Cdd:cd17387 333 AVQGMITGIRGLCNGLGPALFGFVFY 358
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
92-234 |
3.24e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 78.08 E-value: 3.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-AIVTDIS 170
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFakqvreheGMFFVAPALFALTLAVINVVFVYACF 234
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVL--------AQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
86-453 |
2.35e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 77.27 E-value: 2.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 86 NSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFT------IFVLARIVGGISKGNI 159
Cdd:cd06173 31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslslwlLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 160 SLSTAIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkQVREHEGMFFVAPALFALTLAVInvVFVYACFKETLP 239
Cdd:cd06173 111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-ALLGPGGAFAINALSFLLSALLL--LFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 240 QEKRAHsVGSKLQEAYDLIQPVSLFkfsavhhakksdldqmqRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKM 319
Cdd:cd06173 188 ESSSLL-LRDLREGLRYLRRSPLLR-----------------LLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 320 FFFIGI---IMSIVQGGYVRRIKPGKEKKVALMGIGLvipSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYG 396
Cdd:cd06173 250 LAAFGVgalLGALLLGRLSKRRRRGRLLLIGALLLGL---ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 397 QDDQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLILRKL 453
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
110-450 |
7.09e-15 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 75.72 E-value: 7.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 110 GAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGIskGNI-SLSTAIVTDISTPQTRGKGMAL----IGI 184
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAIsSVVMALLADLTREENRTKAMALigasIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 185 AFSVGFLIGPLIGAYFAkqvrehegmffvAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSKLQEAYDLIQPVSLf 264
Cdd:cd17472 131 AFAISMVLGPLLAAHLG------------VSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLL- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 265 kfsavhhakksdldqmqRIGLVYFLYLFLYSGLEFTL-TFLTHNRFQYDSMkqgKMFFFIGIIMSIVQGGYVRRI--KPG 341
Cdd:cd17472 198 -----------------RLDFSIFILHFVLMAFFYILpLLLTQLGGGKGQL---WKVYLPAILIGFILMVPFVIYaeKKG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 342 KEKKVALMGIGLVIPSFLVIGLASTTTVM-YCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGP 420
Cdd:cd17472 258 KMKQVFVSSILLIAVGFLLLLFAATSLWLlIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGG 337
|
330 340 350
....*....|....*....|....*....|
gi 919024404 421 MAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17472 338 ALGGLLWGLLGYSSVFLTILILALLWLLVS 367
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
98-444 |
1.36e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 74.92 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 98 FSLLQFLAspmiGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNIS-LSTAIVTDISTPQTRG 176
Cdd:cd17320 47 FALGQLLY----GPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAELA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 177 KGMALIGIAFSVGFLIGPLIGAYFAkqvrehegMFFVAPALFA--LTLAVINVVFVYACFKETLPQEKRAHSVGSKLQEA 254
Cdd:cd17320 123 KIFSLLMMILAIAPALAPLLGGLLL--------LFFGWRAIFVflALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 255 ydliqpVSLFKfsavhhakksdldqmQRIGLVYFLYLFLYSGLEFT----LTFLTHNRFQYDSMKQGKMFFFIG---IIM 327
Cdd:cd17320 195 ------KRVLK---------------NRRFLGYALALGLSFAGLFAylaaAPFIYIEQLGLSPAQFGLLFALNAialILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 328 SIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVM-----YCGLALFSFASATVVPCLTTLMSSyGQDDQKG 402
Cdd:cd17320 254 SLLNGRLVRRFGP---RRLLRLGLLLLLAAALVLLLAALLGGLslwplVAPLFLIFFGFGLIFPNATSLALE-PFPHVAG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 919024404 403 TVMGIFRSL----GALARALGPMAASIVYW--SLGSTACYSIGGVLLV 444
Cdd:cd17320 330 TASALLGFLqfliGALAGALVGLLPNGTALpmGLLILVLGLLALLLLI 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
92-460 |
8.04e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.88 E-value: 8.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGIskGNISLSTAIVTDIST 171
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL--GLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 172 --PQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQvreHEGMFFVAP-ALFALTLAVINVVFVYACFKETLPQEKRAHSVG 248
Cdd:COG0738 124 lgPETAASRLNLLHAFFSLGALLGPLLGGLLILL---GLSLSWHLPyLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 249 SKLQeaydliqpvSLFKFSAVhhakksdldqmqrigLVYFLYLFLYSGLEFTL-----TFLTHNRFQYDSM-KQGKMFFF 322
Cdd:COG0738 201 ASLK---------SLLKNPRL---------------LLGGLAIFLYVGAEGAIgdwlpLYLKDVLGLSEATaALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 323 IGI-IMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSyGQDDQK 401
Cdd:COG0738 257 GGMtIGRFLGGFLLKRFGP---VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD-GLGKRT 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 919024404 402 GTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLILRKLDLKKNTE 460
Cdd:COG0738 333 AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
92-204 |
1.69e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 68.36 E-value: 1.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAIVTDIS 170
Cdd:cd17502 33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLV 112
|
90 100 110
....*....|....*....|....*....|....
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQV 204
Cdd:cd17502 113 PPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHL 146
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
86-450 |
4.31e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.21 E-value: 4.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 86 NSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTA 164
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGImTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 165 IVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkQVREHegmffvapALFALTLAVINVVFVYACFKETLPQEKRA 244
Cdd:cd17473 112 LIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWR--------APFLVYLLALPVLILVLLFLPEPARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 245 HSVGSKLQEAYDLIQPVSLfkfsavhhakksdldqmqrIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIG 324
Cdd:cd17473 183 AASPGAATAAALPWKRVLP-------------------IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 325 IIMSIVQGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTV 404
Cdd:cd17473 244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 919024404 405 MGIFRSLGALARALGPMAASIVYWSLGS-TACYSIGGVLLVAPLLIL 450
Cdd:cd17473 324 MGIVTSAFFLGQFLSPLVLGPLVNLTGGlSGAFLILGVLALVLAIVL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
92-201 |
4.80e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.37 E-value: 4.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDIS 170
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGgLMPGALALIAELF 131
|
90 100 110
....*....|....*....|....*....|.
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFA 201
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
92-450 |
9.80e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 66.44 E-value: 9.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDIS 170
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGgSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFAltlavinVVFVYACFKETLPQEKRAHSVGSk 250
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLV-------VAVLAWLFLRDPPAGAAAAAKAS- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 lqeaydLIQPVSLFKFSAVHhakksdldqmqRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGIIMSIV 330
Cdd:COG2223 195 ------LRDQLEALRDPRFW-----------LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 331 Q--GGYV-RRIkpGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGI 407
Cdd:COG2223 258 RplGGWLsDRI--GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 919024404 408 FRSLGALARALGPMAASIVYWSLGS-TACYSIGGVLLVAPLLIL 450
Cdd:COG2223 336 VGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLT 379
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
91-230 |
1.45e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 65.72 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 91 GGLIGSLFSLLQFLASPMIGAASDYYGRKPLMllnligiAVSYAIWAVST-------NFTIFVLARIVGGISKGNIS-LS 162
Cdd:cd17328 36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWIL-------AVGILIWSAATllssfapNFWQLLLFRALVGIGEASYSpIA 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 919024404 163 TAIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALtLAVINVVFV 230
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVL-LAILLLLFV 175
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
29-450 |
7.38e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 63.44 E-value: 7.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 29 VFISLIIDLLAFTMILPLLPSLLDYYGHHDEGGLyhvllqyvhslrsligapdtprwnsVLFGGLIGSLFSLLQFLASPM 108
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLV-------------------------ELWSGLAFSSTFLVSAIFSPI 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 109 IGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTdISTPQTR-GKGMALIGIAFS 187
Cdd:cd17391 56 WGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIA-SQTPKEKsGWALGTLSTGVV 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 188 VGFLIGPLIGAYFAkqvrEHEGMFFVapalFALTLAVINVVFVYACF--KETLPQEKRAHSVGSKLQEAYDLIQP--VSL 263
Cdd:cd17391 135 AGTLIGPLLGGFLA----DLFGIRNV----FFITGGLLFLAFLLTLFfvKEDFKPVEKKKMVSTKEVWNSVPNPSllISL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 264 FKFSAVhhakksdlDQMQRIGLVYFLYLFLYSgleftltfLTHNrfqydsmkQGKMFFFIGIIMS------IVQGGYVRR 337
Cdd:cd17391 207 FVTTFI--------IQLANQSIEPILTLYIRQ--------LMGD--------ASNLAFISGLVFSatgvssLLSAPRLGK 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 338 I--KPGKEKKVAlmgIGLVIPSFLVIGLASTTTVMYCGL--ALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGA 413
Cdd:cd17391 263 LgdRIGHHRILL---GALLASALLYIPQAFVQTPWQLGIlrFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQY 339
|
410 420 430
....*....|....*....|....*....|....*..
gi 919024404 414 LARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17391 340 LGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
93-450 |
7.41e-11 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 63.45 E-value: 7.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 93 LIGSLFSLLqflASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFT------IFVLARIVGGISKGNISLSTAI- 165
Cdd:cd17386 37 LMGSIPPLF---SSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTtvpsvwWFYLSAIPLALFGGFTAFLSASf 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 166 --VTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVrEHEGMFFVAPALFALTLavinvvfVYACFKETLpqekr 243
Cdd:cd17386 114 ayISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKAL-GYAWSFSISAALLLIAL-------LYILFFLTL----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 244 ahsvgsklqeaydLIQPVslfkfsavhhakksdldqmqrigLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGkmFF-- 321
Cdd:cd17386 181 -------------LILLL-----------------------LAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFS--YFst 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 322 ---FIGIIMSIVQGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASaTVVPCLTTLMSSYGQD 398
Cdd:cd17386 223 lgsLIYLTGMLGGVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNG-IVGPMIRSILSKLVPK 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 919024404 399 DQKGTVMGIFrslgALARALGPMAASIVYWSLGST-------ACYSIGGVLLVAPLLIL 450
Cdd:cd17386 302 SEQGKIFSLL----SVLESLSPLVASPIYNNIYKAtlttfpgFFFLLSAGLLLIPVILI 356
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
92-451 |
2.39e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.82 E-value: 2.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISK-GNISLSTAIVTDIS 170
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEaGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEG--MFFVAPALFALTLAVINVVFVYacfketlpqekrahsvg 248
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLL----LLFGwrWAFIIEGLLGLLLAVLWWFYLR----------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 249 sklqeaydliqpvslfkfsavhhakksdldQMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQG---KMFFFIGI 325
Cdd:cd17319 180 ------------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGllaAIPFLAGA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 326 IMSIVQGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVM 405
Cdd:cd17319 230 IGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 919024404 406 GIFRSLGALARALGPMAASIVYWSLGS--TACYSIGGVLLVAPLLILR 451
Cdd:cd17319 310 GLINSGGNLGGFVAPLLIGYLVDATGSytAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
104-224 |
8.36e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 60.28 E-value: 8.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 104 LASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPQTRGKGMALIG 183
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 919024404 184 IAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAV 224
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
92-261 |
1.48e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 60.03 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAI-VTDIS 170
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVlNTEFL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIgAYFAKQVRehegmffvapaLFALTLAVINVVFVYACFkeTLPQEKRAHSVGSK 250
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIPDWR-----------WLQLAVSLPTFLFFLLSW--FVPESPRWLISQGR 275
|
170
....*....|.
gi 919024404 251 LQEAYDLIQPV 261
Cdd:TIGR00898 276 IEEALKILQRI 286
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
92-385 |
2.21e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.72 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAIVTDIS 170
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFhPEGARLASQAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQtRGKGMALIGIAFSVGFLIGPLIGAYFAkqvreheGMFFVAPALFALTLAVINVVFVYACFKETLPQEKRAHSVGSK 250
Cdd:cd17478 114 GGR-RGLAMSIFSVGGNLGFALGPLIAAALV-------ALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 LQEAYDLIQPVSLFkfsavhhakksdldqmqRIGLVYFLYLFLYSGLEFTLTFLTHnrfQYDSMKQGKM----FFFIGII 326
Cdd:cd17478 186 ARSTLKGVWRALLL-----------------LLIIVFLRSWVLSSLTTFLPFYLVQ---RGYSLVFAGLllslFLFAGAI 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 919024404 327 MSIVQGGYVRRIkpgKEKKVALMGIGLVIPSFLVI----GLASTTTVMYCGLALFSFASATVV 385
Cdd:cd17478 246 GTLIGGPLSDRF---GRRRVIIASLLLAAPFLLLFlltpGIWSYILLVLAGFLLFASFPVTVV 305
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
92-231 |
2.57e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 59.18 E-value: 2.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLL-NLIGIaVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDIS 170
Cdd:cd06179 35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGgNLLGV-VGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELV 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQvrEHEG---MFFVAPALFALTLAVInvVFVY 231
Cdd:cd06179 114 PNKYRGLVQGVVNLVASPGSALGPLIAGALVEA--NAAGwrwIFYINAIFNALALILL--FFFY 173
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
98-377 |
2.82e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 58.77 E-value: 2.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 98 FSLLQFLASPMigaaSDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNIS-LSTAIVTDISTPQTRG 176
Cdd:PRK11102 39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEFS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 177 KGMALIGIAFSVGFLIGPLIGAYFAKQVREHegMFFVAPALFALtLAVINVVFVyacFKETLPQEKRahsvgSKLQEAYD 256
Cdd:PRK11102 115 RMMSFVTLVMTIAPLLAPIIGGWLLVWFSWH--AIFWVLALAAI-LAAALVFFF---IPETLPKERR-----QPFHLRTT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 257 LIQPVSLFKFSAVhhakksdldqmqriglvyfLYLFLYSGLEFT--LTFLTHNRFQYD-----SMKQGKMFFFIGI---- 325
Cdd:PRK11102 184 IRNFASLFRHKRV-------------------LGYMLASGFSFAgmFSFLTAGPFVYIelngvSPQNFGYYFALNIvflf 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 326 IMSIVQGGYVRRIKPGKEKKVAL-----MGIGLVIPSFLVIGLAStttvMYCGLALF 377
Cdd:PRK11102 245 VMTIINSRFVRRVGALNMLRFGLwiqfiMGIWLVVSALLDLGFWA----LVVGVAAF 297
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
92-460 |
3.32e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.76 E-value: 3.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQF---LASPMIGAASDYYG-----RKPLMLLNLIGIAVSYAI------WAVSTNFTIFVLARIVGGISKG 157
Cdd:COG2211 46 ALVGLILLVARLwdaITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 158 NISLS-TAIVTDIST-PQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAVINVVFVYACFK 235
Cdd:COG2211 126 LVNIPySALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 236 ETLPQEKRAHSVGSKLQeaydliqpvSLFKFsavhhakksdlDQMQRIGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMK 315
Cdd:COG2211 206 ERPVPEEEKVSLKESLK---------ALLKN-----------RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 316 QGKMF---FFIGIIMSIVQGGYVRRIkpGKeKKVALMGIGLVIPSFLVIGLA--STTTVMYCGLALFSFASATVVPCLTT 390
Cdd:COG2211 266 VGLLLalyFLAALLGAPLWPRLAKRF--GK-KKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 391 LMS---SYGQ----DDQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTA--------------CYS-IGGVLLVAPLL 448
Cdd:COG2211 343 MLAdvvDYDEwktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirlLFFlLPAVLLLLAAL 422
|
410
....*....|..
gi 919024404 449 ILRKLDLKKNTE 460
Cdd:COG2211 423 LLLFYPLTRERH 434
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
107-419 |
1.19e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 107 PMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAIVTDISTPQTRGKGMALIGIA 185
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAImPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 186 FSVGFLIGPLIGAYFAKqvrehegmFFVAPALFALTLAVINVVFVYAcfketlpqekRAHSVGSklqeaydliqpvslfk 265
Cdd:cd17321 129 VGIGAALGPLLGGLLLE--------LFGWRWIFLINVPIGLVALLLA----------RTFSGAV---------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 266 fsavhhakksdldqmqrigLVYFLYLFLYSGLEFTLTFLTHNRFQYDSMKQGKMFFFIGI---IMSIVQGGYVRRIKPGK 342
Cdd:cd17321 175 -------------------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALamlVAAPLAGRLADRFGPRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 343 ekkvaLMGIGLVIPSFLVIGLA-----STTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARA 417
Cdd:cd17321 236 -----VLVAGLLLTAVGLLLLAllgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGA 310
|
..
gi 919024404 418 LG 419
Cdd:cd17321 311 LG 312
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
87-224 |
1.45e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 56.43 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSllqflaspmiGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAI- 165
Cdd:cd17315 42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLy 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 919024404 166 VTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAV 224
Cdd:cd17315 112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLL 170
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
107-223 |
1.48e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.43 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 107 PMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGN-ISLSTAIVTDISTPQTRGKGMALIGIA 185
Cdd:cd17503 49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 919024404 186 FSVGFLIGPLIGAYFAKQVREHeGMFFVA--PALFALTLA 223
Cdd:cd17503 129 ILLAPAIGPTLGGWLTDNLSWR-WIFYINlpIGILALLLA 167
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
87-224 |
2.83e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 55.65 E-value: 2.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSllqflaspmiGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNIS-LSTAI 165
Cdd:cd17359 44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 166 VTDISTPQTRGKGMAL----IGIAFSVGFLIGPLIGAYFAKQVREHEG---MFFVA--PA--LFALTLAV 224
Cdd:cd17359 114 IAEVAPAEIRGRLVSLnqlmIVFGQLLAYIVNYLIANAGGADWLGAEGwrwMLGLEaiPAilFLLGMLFI 183
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
92-450 |
3.18e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.26 E-value: 3.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-AIVTDIS 170
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEGMFFVAPALFaLTLAVINVVFVYACFKETLPQEKRAhsvgsk 250
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVG----TAGALPFLIAAVL-LLLALVPLLLTRRAAPEIEEAESIS------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 251 lqeaydliqpvslfkfsavhhakksdLDQMQRIGLVYFLYLFLYSGLEFTLT-----FLTHNRFQYDSMKQGKMFFFIG- 324
Cdd:cd17477 183 --------------------------LRRLLRIAPLALLGAFVAGFLEGAFYsllplYGLRLGLSVAQAALLLAAFVLGg 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 325 IIMSIVQGGYVRRIkpGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTV 404
Cdd:cd17477 237 LLLQWPLGWLADRF--DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 919024404 405 MGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
87-230 |
3.19e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.27 E-value: 3.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWA-VSTNFTIFVLARIVGGISKGNISLST-A 164
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVfA 318
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 919024404 165 IVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAVINVVFV 230
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
103-200 |
6.57e-08 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 54.28 E-value: 6.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 103 FLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGI-SKGNISLSTAIVTDISTPQTRGKGMAL 181
Cdd:cd17379 47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLfGKGGWMTGYVLVTEFVGSKYRRTVGIV 126
|
90
....*....|....*....
gi 919024404 182 IGIAFSVGFLIGPLIgAYF 200
Cdd:cd17379 127 YQMFFTLGLLILPGI-AYF 144
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
96-451 |
1.49e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.43 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 96 SLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLAR-IVGGISKGNISLS-TAIVTDISTPQ 173
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGGGGAGTLAAVaFATVAAWWFER 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 174 TRGKGMALIGIAFSVGFLIGPLIGAyfakQVREHEG--MFFVAPALFALTLAVINVVFvyacfketlpqeKRAHSVGSKL 251
Cdd:cd17355 125 RRGLALGILTAGGGLGSLVFLPLGA----ALIEAFGwrTALLVLALLALLVLVPVLLL------------LRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 252 QEAYDLIQPVSLfkfSAVHHAKKSdlDQMQRIGLVYFLYLFLYSGLEFTL-TFLTHNRFQYDSMKQGKMFFFIGIIMSIV 330
Cdd:cd17355 189 RAYDDASPASPG---STLKEALRS--ASFWLLALAFFLCGFAVVGLIVHLvPYLADRGISPAAAAVALALIGLFNIVGRL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 331 QGGYV-RRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCglALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFR 409
Cdd:cd17355 264 LSGWLgDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFA--ALFGLGWGATVPLTAALAARYFGARSYGTLFGLVF 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 919024404 410 SLGALARALGPMAASIVYWSLGS--TACYSIGGVLLVAPLLILR 451
Cdd:cd17355 342 APHQLGSALGPWLGGLLYDRTGSytAAWALAVALGLIAALLVLP 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
87-225 |
1.72e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.95 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYGR--KPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGI-SKGNISLST 163
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLW 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 919024404 164 AIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAVI 225
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
96-450 |
1.86e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.96 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 96 SLFsLLQFLASPMIGA-ASDYYGRKPLMLLNLIgIAVSYAIW-AVSTNFTIFVLARIVGGISKGN-ISLSTAIVTDISTP 172
Cdd:cd17323 41 SLF-VLGFGLGPLIWApLSELYGRRPVYLVSLF-IFVIFQIGcALAPNIAMLIILRFLQGFFGSSpLAIGAGTIADLFTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 173 QTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEGMffvaPALFALTLAVINVVFVYACFketlpqekrahsvgsklq 252
Cdd:cd17323 119 EERGKAMGVYSLGPLLGPALGPIIGGFIT----QSLGW----RWIFWFLAIISGFCLILIFL------------------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 253 eaydLIQPVSLFKFSavhhakksdldqmqrIGLVY-FLYLFLysgleFTLTFLTHNRFQYDSMKQGKMF--FFIGIIMSI 329
Cdd:cd17323 173 ----FLPIVLLLGLY---------------VGLVYaILYLFL-----TAFPYVFGEVYGFSPGEVGLMYlpIGIGALIGS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 330 VQGG------YVRRIKPGKEKKVALMG-IGLVIPSFLV-IGL---ASTTT------VMYCGLALFSFASATV-VPCLTTL 391
Cdd:cd17323 229 IIGGrlsdyyYRRLKKKNGGKPEPEARlPPAFIGAFLFpIGLfifGWTIYphihwiVPIIGSAFFGFGLMLIfQSSLTYL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 919024404 392 MSSYGQddQKGTVMG---IFRSLGAlarALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17323 309 VDSYPK--YAASALAantLVRSIFA---AIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIP 365
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
85-230 |
2.81e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 85 WNSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLST 163
Cdd:cd17370 230 GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIER 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 164 AIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrehEGMFFVAPALFALTLAVINVVFV 230
Cdd:cd17370 310 AAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLW------DLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
87-450 |
4.27e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 4.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYG-RKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-A 164
Cdd:cd17370 32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRdA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 165 IVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHegmffvAPALFALTL--AVINVVFVYACFKETLPQEK 242
Cdd:cd17370 112 LLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGN------YRTIFLLAAipALLALLILLFVVKEYPRPPK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 243 RAHSVGSKLQEAYD-----LIQPVSLFKFS------AVHHAKKSDLDQMQrIGLVYFLYLFLYSGLEFTLtflthnrfqy 311
Cdd:cd17370 186 LRKKSKKTSLKKLPkafwlYLLAVALFALGnfsfafLILRAQELGLSAAL-IPLLYALFNLVYALAAYPA---------- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 312 dsmkqGKMFFFIGIimsivqggyvrrikpgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTL 391
Cdd:cd17370 255 -----GRLSDRIGR------------------KKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 919024404 392 MSSYGQDDQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17370 312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
92-450 |
6.43e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 6.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGG--ISKGNISLSTAIVTDi 169
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagIAVGNVLLPGLIKRW- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 170 sTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVA-PALFALTLAvinvvfvyacfketLPQEKRAHSVG 248
Cdd:COG2807 135 -FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAlLALLALLLW--------------LPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 249 SKLQEAYDLIQPVSlfkfsavhhakksdldqmQRIGLVYFLYLFLYSGLEFTL-----TFLTHNrfQYDSMKQGKMFF-- 321
Cdd:COG2807 200 AAAPAAASLRSLWR------------------SPLAWLLTLFFGLQSLLYYAVvawlpPILRDA--GLSAATAGLLLSlf 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 322 -FIGIIMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSY-GQDD 399
Cdd:COG2807 260 qLAGIPGSLLVPLLADRLGD---RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRaRTPA 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 919024404 400 QKGTVMGIFRSLGALARALGPMAASIVYWSLGStacYSIGGVLLVAPLLIL 450
Cdd:COG2807 337 EAAALSGMAQSVGYLLAALGPLLVGALHDATGS---WTAALLLLAALAVLM 384
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
82-244 |
8.59e-07 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 50.96 E-value: 8.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 82 TPRWNSVL-FGGLIGSLFSllqflaSPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTI----FVLARIVGGISk 156
Cdd:cd17449 63 TAHWNLYInLGGFLVGLFS------VTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLhvayFLIGRILSGLL- 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 157 GNISL----STAIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAyfakQVREHEGmfFVAPALFALTLAVINVVFVYA 232
Cdd:cd17449 136 GDFNGilagCFAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGG----QWRKAQG--YINPFWLVLALNLAAALYAAF 209
|
170
....*....|..
gi 919024404 233 CFKETLPQEKRA 244
Cdd:cd17449 210 CVGESVKEPKSA 221
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
89-426 |
9.22e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.82 E-value: 9.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 89 LFGGLIGSLFSllqflaspmiGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAIVT 167
Cdd:TIGR00895 62 LIGMAFGALFF----------GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLmPNLNALVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 168 DISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHeGMFFVApALFALTLAVINVVFVYACFKETlpQEKRAHSV 247
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR-SLFYVG-GIAPLLLLLLLMRFLPESIDFL--VSKRPETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 248 GSKLQEAYDLIQPVSLFKF---SAVHHAKKSDLD-----QMQRIGLV----YFLYLFLYSGLEFTLTFLTHNRFQYDSMK 315
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSALpeqKSTQGTKRSVFKalfqgKTARITVLlwllYFMLLVGVYFLTNWLPKLMVELGFSLSLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 316 QGKMFFFI--GIIMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMS 393
Cdd:TIGR00895 288 ATGGALFNfgGVIGSIIFGWLADRLGP---RVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMA 364
|
330 340 350
....*....|....*....|....*....|...
gi 919024404 394 SYGQDDQKGTVMGIFRSLGALARALGPMAASIV 426
Cdd:TIGR00895 365 LFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
93-451 |
9.36e-07 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 50.96 E-value: 9.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 93 LIGSLFSLLQFLA--SPMIGAASDYYG-----RKP-----LMLLNLIGIAVSYAIWAVSTnfTIFVLARIVGGISKGNIS 160
Cdd:cd06176 37 LVGLLIALHYLVAplRVWIGHRSDTHPlrgyrRTPyiwlgMLLLALGLALAPFAALLLAG--AAFWLGLALAVLAFLLYG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 161 LST--------AIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQvrehegmfFVAPALFALTLAVINVVFVYA 232
Cdd:cd06176 115 IGVgaagtaflALLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGRLLDP--------YSPERLIQVFQIVALVALLLA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 233 CFKeTLPQEKRAHSVGSKLQEAYDLIQPVSLFKFSAvhhakksdldqmQRIGLVYFLYLFL--------------YSGLE 298
Cdd:cd06176 187 LLA-LWGVERRRSRAALAAEEAPPETFREALRLLWA------------SPQARRFFIFLFLstlalfmqdvilepFGGEV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 299 FTLTFLTHNRFQydsmkqgkMFFFIGIIMSIVQGGYVRRIKPGKeKKVALMGIGLVIPSFLVIGLASTT---TVMYCGLA 375
Cdd:cd06176 254 FGMSVGETTRLT--------AIWGGGTLLGMLLAGFLLSRRLGK-KRTAALGCLLSALGFLLLALAGLLgnpWLFRPGVF 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 376 LFSFAS-ATVVPCLTTLMSSYGqDDQKGTVMGIFRSLGALARALGPMAA----SIVYWSLGS-----TACYSIGGVLLVA 445
Cdd:cd06176 325 LLGLGNgLFTVGALTLMMDLTG-EGTAGLFMGLWGAAQALARGLGTLLGgalrDLLRALFGSpalayGLVFLLEAVLLLV 403
|
....*.
gi 919024404 446 PLLILR 451
Cdd:cd06176 404 ALLLLR 409
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
90-200 |
1.51e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.89 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 90 FGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-AIVTD 168
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfVLGME 105
|
90 100 110
....*....|....*....|....*....|..
gi 919024404 169 ISTPQTRGKGMALIGIAFSVGFLIGPLIGAYF 200
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLI 137
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
85-450 |
1.63e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 85 WNSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLST 163
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGgEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 164 AIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEG--MFFVAPALFALTLAVINVVFVYacfketlpqe 241
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwrILFLIGALPALLALLLRRRTLL---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 242 krahsvgsklqeaydliqpVSLFKFSAVhhakksdldqmqriGLVYFLYLFLYSGLEFTLTFLTHNRFQYDSmkqgkMFF 321
Cdd:cd17316 182 -------------------LILLWFFIS--------------FGYYGLTTFLPTYLQTVLGLSPATSSLYLL-----LIS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 322 FIGIIMSIVQGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGqDDQK 401
Cdd:cd17316 224 LGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP-TEVR 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 919024404 402 GTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLIL 450
Cdd:cd17316 303 ATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
94-424 |
3.05e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 49.24 E-value: 3.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 94 IGSLFSLLQ--FLASPMI-GAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDI 169
Cdd:cd17333 33 VSVIFSSQNagYLIGSLLaGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiLDTGANTFVGAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 170 StPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVapalfALTLAVINVVFVYACFKETLPqekrahsvgs 249
Cdd:cd17333 113 F-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLI-----IGLIYLLLAILILLTLFPELP---------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 250 klqeaYDLIQPVSLFKFSAVHHAKKSdldqmQRIGLVYFLYLFLYSGLEFTL-TFLTHNRFQYDSMKQGKM-----FFFI 323
Cdd:cd17333 177 -----SARNPQQSVGAFSASASRLLR-----NPSIILGALALFLYVGAETAFsSWVPSYLVEKKHVSDGLAgyllsGFWV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 324 GIIMSIVQGGYV-RRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQdDQKG 402
Cdd:cd17333 247 GITIGRLLGGPIsRRIKP---HTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKG 322
|
330 340
....*....|....*....|..
gi 919024404 403 TVMGIFRSLGALARALGPMAAS 424
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
87-451 |
3.38e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 3.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYG-RKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAI 165
Cdd:cd17490 29 SLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 166 VTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEGMFFvaPALFALTLAVINvvFVYACFKETLPQEKraH 245
Cdd:cd17490 109 YASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIA----EHFGMRA--PFLLAALAGVLG--FILSLFIKEERREK--K 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 246 SVGSKLQEAYDLIQPVSLFKFSAVhhakkSDLDQMQRIGLVYF---LYLFLYSGLEFTLTFLThnrfqydsmkqgkMFFF 322
Cdd:cd17490 179 PVLTELKELLSVLKDKKLLFFSLL-----AILQQMITFSTTFGftpLIAKQLGASSFQLGLLS-------------IIYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 323 IGIIMSIVQGGYVRRIKPGkEKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKG 402
Cdd:cd17490 241 LPNALASLLSGTLFYKKLG-ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 919024404 403 TVMGIFRSLGALARALGPMAASIV--YWSLgSTACYSIGGVLLVAPLLILR 451
Cdd:cd17490 320 TAMGFFQAIYALGMFLGPVLVGIIseAFGL-QTGFFVIGVIALLAAILSLA 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-229 |
3.52e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 11 NETGEKVGTNKSSKMVYVVFISLIIDLLAFTMILPLLPSLLDYYGHHDEGGLyhvllqyvhslrsligapdtprwnsvlf 90
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI---------------------------- 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 91 gGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDI 169
Cdd:cd17473 236 -GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSL 314
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 170 STPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVApALFALTLAVINVVF 229
Cdd:cd17473 315 VPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLIL-GVLALVLAIVLLLL 373
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
87-225 |
3.88e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.76 E-value: 3.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYGRK-PLMLLNLIGIAVSYAIWAVSTNFTIFVL-ARIVGGISKGNISLSTA 164
Cdd:cd17353 247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKnTLSIAFLIQGVAMFLLPFIGSVAVLFVLgVALIGFCYGGGFALFPA 326
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 919024404 165 IVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVReHEGMFFVAPALFALTLAVI 225
Cdd:cd17353 327 LTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG-YNAAFIIAAALSLVALALA 386
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
96-192 |
4.14e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 48.44 E-value: 4.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 96 SLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAI-VTDISTPQT 174
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIlGTEWTTPRH 121
|
90
....*....|....*...
gi 919024404 175 RGKGMALIGIAFSVGFLI 192
Cdd:cd17374 122 RALAITLTSCFFSIGQML 139
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
319-454 |
4.61e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.72 E-value: 4.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 319 MFFFIGIIMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQD 398
Cdd:COG2223 48 IPVLVGALLRIPLGFLVDRFGP---RRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPP 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 399 DQKGTVMGIFRSLGALARALGPMAASIVYWSLG-STACYSIGGVLLVAPLLILRKLD 454
Cdd:COG2223 125 DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLILGILLLVVAVLAWLFLR 181
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
26-197 |
7.98e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 47.95 E-value: 7.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 26 VYVVFISLIIDLLAFTMILPLLPSLLDYYGHhdegglyhvllqyvhslrsligapdtprwnsvlfgglIGSLFS---LLQ 102
Cdd:cd17384 2 LVIVYVALLLDNMLLTVVVPIIPDYLNENVR-------------------------------------VGLLFAskaLVQ 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 103 FLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLS-TAIVTDIST-PQTRGKGM- 179
Cdd:cd17384 45 LITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLYPdDKERGKAMg 124
|
170
....*....|....*....
gi 919024404 180 -ALIGIAfsVGFLIGPLIG 197
Cdd:cd17384 125 iALGGLA--LGVLVGPPFG 141
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
92-229 |
8.63e-06 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 48.03 E-value: 8.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVS---TNFTIFVLARIVGGISKGnISLSTAI--V 166
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACG-LSTGFVPmyL 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 919024404 167 TDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAVINVVF 229
Cdd:cd17357 131 QEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFF 193
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
39-238 |
1.20e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 47.22 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 39 AFTMILPLLPSLLDYYGHHDEGGLYhvllqyvhslrsligapdtprwnsvLFGGLIGSLFSLLQFLASPMIGAASDYYGR 118
Cdd:PRK09874 29 AFSLVMPFLPLYVEQLGVTGHSALN-------------------------MWSGLVFSITFLFSAIASPFWGGLADRKGR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 119 KPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGA 198
Cdd:PRK09874 84 KIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGG 163
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 919024404 199 YFAKQVREHEGMFFVAPAL---FALTLAVINVVFVYACFKETL 238
Cdd:PRK09874 164 LLADSYGLRPVFFITASVLflcFLVTLFCIRENFQPVSKKEML 206
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
319-453 |
1.26e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 319 MFFFIGIIMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQD 398
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGR---RRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPP 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 919024404 399 DQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLILRKL 453
Cdd:COG2814 130 ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
87-230 |
1.45e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.17 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLN-LIGIAVSYAIWAVSTN-FTIFVLARIVGGISKGNISLSTA 164
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCaLLGALAALLLPLVPGLpLALLVLLFLWGGAAGPLYTLALA 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 919024404 165 IVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFakqvrehegMFFVAPALFALTLAVINVVFV 230
Cdd:cd17477 301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL---------MDAFGPHGLFLFLAAVALLFL 357
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
92-230 |
3.04e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.21 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKG-NISLSTAIVTDIS 170
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGmGWPPCGRTVTKWF 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 919024404 171 TPQTRGKGMALIGIAFSVGFLIGPLI-GAYFAKQVREHEGMFFvaPALFALTLAVINVVFV 230
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIV--PGIIAIIVSLICFLLL 171
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
95-455 |
6.35e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 45.30 E-value: 6.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 95 GSLFSLLQFLASP----MIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLAR-IVGGISKGNISLSTAIVTDI 169
Cdd:PRK12307 55 GAFLATAAFIGRPfggaLFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRfIVGMGMAGEYACASTYAVES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 170 STPQTRGKGMALIgiafSVGFLIGPLIGAYFAKQVREHEGMffvAPALFALTLAVINVVFVYACFKETLP-QEKRAHSVG 248
Cdd:PRK12307 135 WPKHLKSKASAFL----VSGFGIGNIIAAYFMPSFAEAYGW---RAAFFVGLLPVLLVIYIRARAPESKEwEEAKLSGKG 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 249 SKLQEAYDLIQPVSLFKFSAVHHAkksdldqmqrIGLVYFLYLFLYSGLEFTL-----TFLTHNRFQYDSMKQGKMFFFI 323
Cdd:PRK12307 208 KHSQSAWSVFSLSMKGLFNRAQFP----------LTLCVFIVLFSIFGANWPIfgllpTYLAGEGFDTGVVSNLMTAAAF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 324 GIIM-SIVQGGYVRRIKPGKEKKVALMGIGLVIPSFLVIGLASTTTVMYC--GLALFSFASATVVPcltTLMSSYGQDDQ 400
Cdd:PRK12307 278 GTVLgNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGAClfGLMATNVGVGGLVP---KFLYDYFPLEV 354
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 919024404 401 KGTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSIGGVLLVAPLLILRKLDL 455
Cdd:PRK12307 355 RGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAALTFIVAFWTATILLIIGLSI 409
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
92-202 |
6.61e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.96 E-value: 6.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVST---NFTIFVLARIVGGISKGNIS-LSTAIVT 167
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASvLAPMYIS 128
|
90 100 110
....*....|....*....|....*....|....*
gi 919024404 168 DISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAK 202
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNK 163
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
319-454 |
7.84e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 7.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 319 MFFFIGIIMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQD 398
Cdd:pfam07690 40 LFSLGYALAQPLAGRLSDRFGR---RRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 399 DQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTACYSI-GGVLLVAPLLILRKLD 454
Cdd:pfam07690 117 EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIlAILSLLAAVLLLLPRP 173
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
87-224 |
9.18e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 9.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYY-GRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNIS-LSTA 164
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLpLSFA 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 165 IVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAV 224
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
75-222 |
1.85e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.92 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 75 SLIGAPDTPRWnsvlFGGLigslfsllqflaspMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGI 154
Cdd:PRK03893 59 SLISAAFISRW----FGGL--------------LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGM 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919024404 155 S-KGNISLSTAIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYfakqVREHEG---MFFV--APALFALTL 222
Cdd:PRK03893 121 GmAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSL----VVPVWGwraLFFIgiLPIIFALWL 190
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
89-225 |
3.02e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 89 LFGGLIGSLFsllqflaspmIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNI-SLSTAIVT 167
Cdd:cd17365 44 LFGMAIGALL----------AGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAmPNAITLVS 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 919024404 168 DISTPQTRGkgmALIGIAFSvGFLIGPLIGAYFAKQVREHEG---MFFVA--PALFALTLAVI 225
Cdd:cd17365 114 EYAPARRRS---LAVTLMFC-GYPLGAALGGFLAAALIPAFGwrsVFLLGgvPPLILLPLLRG 172
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
92-225 |
3.32e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 3.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASD-YYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIV----GGISKGNISLSTAIV 166
Cdd:cd17471 35 GIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVllslGAAAFPQLFALAREY 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 919024404 167 TDISTPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVrEHEGMFFVAPALFALTLAVI 225
Cdd:cd17471 115 ADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVL-GFTGLFLLAALLYLVVALLV 172
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
87-231 |
3.33e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.94 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 87 SVLFGGLIGSLFSLLQFLASPMIGAASDYYG-RKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAI 165
Cdd:COG2807 248 SAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTL 327
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 166 VTDIS-TPQTRGkgmALIGIAFSVGFLI---GPLIGAYfakqVREHEGmFFVAPALFALTLAVINVVFVY 231
Cdd:COG2807 328 IGLRArTPAEAA---ALSGMAQSVGYLLaalGPLLVGA----LHDATG-SWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
110-206 |
3.87e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 42.40 E-value: 3.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 110 GAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDISTPqTRGKgmALIGIAFSVG 189
Cdd:cd17446 54 GGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMP-TRVR--AVVGTLLGYC 130
|
90
....*....|....*..
gi 919024404 190 FLIGPLIGAYFAKQVRE 206
Cdd:cd17446 131 YTLGQLILAGVAYAIRD 147
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
93-249 |
4.07e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 93 LIGSLFslLQFLaspmIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNIS-LSTAIVTDIST 171
Cdd:PRK15402 58 LAGGMF--LQWL----LGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGaVGYAAIQESFE 131
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 919024404 172 PQTRGKGMALIGIAFSVGFLIGPLIGAYFAkQVREHEGMFfvapALFALtLAVINVVFVYACFKETLPQEKRAHSVGS 249
Cdd:PRK15402 132 EADAIKITALMANVALLAPLLGPLVGAALI-HVLPWRGMF----VLFAA-LAALSFFGLWRAMPETAGRVGEKLSLKE 203
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
92-230 |
4.62e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 42.35 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASD-YYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST-AIVTDI 169
Cdd:cd17378 36 GLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCAlVLATEP 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 919024404 170 STPQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQVREhegmFFVAPALFALTLAVINVVFV 230
Cdd:cd17378 116 VGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSSWRV----LYFWTSIPALIYCILVYLFA 172
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
79-457 |
5.65e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.06 E-value: 5.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 79 APDTPRWNSVLFGgLIGSLFSLLQFLASPMIGAASDYYG-RKPLMLLN-LIGIAVSYAIWAVSTNFTIFVLARIVGgisk 156
Cdd:COG2270 43 ALGDPAAATALWG-YALAIAGLLVALLAPVLGAIADRSGrKKPFLAFFtLLGVLATAALFFVAPGGLWLGLLLFVL---- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 157 GNISLSTAIV------TDISTPQTRGKgmaLIGIAFSVGFL--IGPLIGAYFAkqVREHEGMFFVAPALFA----LTLAV 224
Cdd:COG2270 118 ANIGFEGSLVfynaflPDIATPEEIGR---VSGLGWALGYLggVLLLLINLAL--FLKPEAFGLPDAGEAVrisfLLTAL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 225 INVVFVYACFKeTLPQEKRAHSVGSK--LQEAYDLIqpvslfkFSAVHHAKksdldqmQRIGLVYFL--YLFLYSGLEFT 300
Cdd:COG2270 193 WWLLFALPLFL-FLPERPRPGPAPPRgaVRAGFREL-------RRTLRELR-------RYRDLLRFLlaYFFYRDGVQTV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 301 LTFLT---HNRFQYDSMKQGKMFF---FIGIIMSIVqGGYV-RRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMYCG 373
Cdd:COG2270 258 IAFAGiyaAGVLGFSTTELIVFGLlvqIVAALGALL-FGRLdDRIGP---KRVILVSLVIWIVVCLAAYFLTTALAFWIL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 374 LALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTAcYSIGG--VLLVAPLLILR 451
Cdd:COG2270 334 GLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQR-LGILSliVFFVIGLVLLL 412
|
....*.
gi 919024404 452 KLDLKK 457
Cdd:COG2270 413 RVKVPR 418
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
92-426 |
9.40e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.46 E-value: 9.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDY----YG-RKPLMLLNLIGIAVSYAI--------WAVSTNFTIFVLARIVGGISKGN 158
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILipnaadigLALGDGPRTWALVLFVLGIVLLD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 159 ISLST------AIVTDISTPQTRGKGMALIGIAFSVGFLIGPLIGAY------FAKQVREHE-GMFFVAPALFALTLAVI 225
Cdd:cd17313 117 FAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAIlwdhnwFGFALGGNLkVPFYIGAIILLVCVLVT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 226 nvvfVYACFKETLPQEKRAHSVGSKLQEaydliqpVSLFKFSAVHHAKKSdldqMQRIGLVYFLYLFLYSGLE-FTLTFL 304
Cdd:cd17313 197 ----LFFVKEPPLSPEAGEHSENPSLGE-------VLKSLLKLLKIMPRS----LLRLLLVIFFWWIAFFPFElFFTDYM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 305 THNRFQYDSMKQ------------GKMFF-FIGIIMSIVQGGYVRRIKPgkeKKVALMGIGLVIPSFLVIGLASTTTVMY 371
Cdd:cd17313 262 GEEVYHGTSAASshygagvrmgawGLLIFsLAFLIFSLPIGKLGKKIGR---KKVYLIGLVLFAVGMALMALVHNVTVAL 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 372 CGLALFSFASATVVPCLTTLMSSYGQDDQK--GTVMGIFRSLGALARALGPMAASIV 426
Cdd:cd17313 339 VLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPI 395
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
344-453 |
1.33e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 344 KKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAA 423
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
90 100 110
....*....|....*....|....*....|
gi 919024404 424 SIVYWSLGSTACYSIGGVLLVAPLLILRKL 453
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
92-203 |
1.41e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 41.19 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLSTAIVTDIST 171
Cdd:pfam06609 81 GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGASPLFIGELMS 160
|
90 100 110
....*....|....*....|....*....|..
gi 919024404 172 PQTRGKGMALIGIAFSVGFLIGPLIGAYFAKQ 203
Cdd:pfam06609 161 NKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQ 192
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
278-453 |
2.31e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 278 DQMQRIGLVYFLYLFLYSGLEFTLTFLthnrfqydsmkqgkMFFFIGIIMSIVQGGYVRRIKPGKEKKVA--LMGIGLVI 355
Cdd:cd06173 15 DWIFTVALPWLVLQLTGSALLVGLVLA--------------AFFLPFLLFSPFAGVLADRFDRRRLLILAdlLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 356 PSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAASIVYWSLGSTAC 435
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170
....*....|....*...
gi 919024404 436 YSIGGVLLVAPLLILRKL 453
Cdd:cd06173 161 FAINALSFLLSALLLLFI 178
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
84-198 |
2.36e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 84 RWNSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVLARIVGGISKGNISLST 163
Cdd:cd17478 225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304
|
90 100 110
....*....|....*....|....*....|....*...
gi 919024404 164 AIVTDIStpqTRGKGMA---LIGIAFSVGFLIGPLIGA 198
Cdd:cd17478 305 VLAQELL---PGNVGLAsglMMGLSFGLGGIGAPVLGA 339
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
86-231 |
2.61e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 86 NSVLFGGLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTNFTIFVL-ARIVGGISKGNISLSTA 164
Cdd:cd06180 228 AGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLsAVLFGGTFMAITALVMA 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919024404 165 IVTDIStPQTRGKGMALIGIAFSVGFLIGPLIGAYFAkqvrEHEGMFFVAPALFALTLAVINVVFVY 231
Cdd:cd06180 308 LARELA-PPAAPRALALMTASFGVGQILGPLLAGWLA----DATGGFAPALILAAAALVVAALLALL 369
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
93-253 |
3.28e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.70 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 93 LIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSYAIWAVSTN-FTIFVLARIVGGISKGNISLSTAIVTDIST 171
Cdd:cd17314 42 TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNsFPLSYACFVFIGAGTGILYGSAVLVTTQYF 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 172 PQTRGKGMALIgiafSVGFLIGPLIGAYFAKQVREHEGMFFVAPALFALTLAVINVVFVYAcFKETLPQEKRAHSVGSKL 251
Cdd:cd17314 122 PDTKGLALGLP----TTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLG-FKEPPDNQARLHVQKKKT 196
|
..
gi 919024404 252 QE 253
Cdd:cd17314 197 QT 198
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
92-152 |
3.58e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 3.58e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYG-RKPLMLLNLIGIAVSY-AIWAVSTNFTIFVLARIVG 152
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFlSLFFVAQIFWLLLLLVILG 97
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
92-225 |
7.50e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 92 GLIGSLFSLLQFLASPMIGAASDYYGRKPLMLLNLIGIAVSY---AIWAVSTNFTIFVLARIVGGISKG--NISLSTAIV 166
Cdd:cd17503 217 GLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTlllAFLTPDTSLWLIILPLFIRGLGMGlvFMPLNTLAL 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919024404 167 TDIStPQTRGKGMAL----------IGIAFSVGFL------IGPLIGAYFAKQVREHEGMFFVAPALFALTLAVI 225
Cdd:cd17503 297 NSLP-PEQIGDATALfntirqlggsIGTALLATLLtnrtqfHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
344-451 |
9.64e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 37.92 E-value: 9.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919024404 344 KKVALMGIGLVIPSFLVIGLASTTTVMYCGLALFSFASATVVPCLTTLMSSYGQDDQKGTVMGIFRSLGALARALGPMAA 423
Cdd:cd17321 61 KRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLG 140
|
90 100
....*....|....*....|....*...
gi 919024404 424 SIVYWSLGSTACYSIGGVLLVAPLLILR 451
Cdd:cd17321 141 GLLLELFGWRWIFLINVPIGLVALLLAR 168
|
|
| |
