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Conserved domains on  [gi|826349104|ref|XP_012519340|]
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PREDICTED: alpha-2A adrenergic receptor [Propithecus coquereli]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11607386)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
49-452 1.47e-162

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


:

Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 459.41  E-value: 1.47e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqpPAEPRCEINDQ 208
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQ----PEGPICKINDE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptql 288
Cdd:cd15322  157 KWYIISSCIGSFFAPCLIMVLVYIRIYQIAK------------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 289 ngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeer 368
Cdd:cd15322      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 369 gggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15322  188 -------------NREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVcDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHD 254

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15322  255 FRRAF 259
 
Name Accession Description Interval E-value
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
49-452 1.47e-162

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 459.41  E-value: 1.47e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqpPAEPRCEINDQ 208
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQ----PEGPICKINDE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptql 288
Cdd:cd15322  157 KWYIISSCIGSFFAPCLIMVLVYIRIYQIAK------------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 289 ngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeer 368
Cdd:cd15322      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 369 gggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15322  188 -------------NREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVcDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHD 254

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15322  255 FRRAF 259
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-441 5.34e-55

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.04  E-value: 5.34e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104   65 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFCTSSIVHLCAIS 143
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  144 LDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppaEPRCEIN------DQKWYVISSCI 217
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDfpedlsKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  218 GSFFAPCLIMILVYVRIYQIAKRRtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapgepap 297
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKS-------------------------------------------------------- 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  298 agpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggAKASRW 377
Cdd:pfam00001 182 --------------------------------------------------------------------------ASKQKS 187
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104  378 RGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFF---WFGYCNSSLNPVIY 441
Cdd:pfam00001 188 SERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLalDCELSRLLDKALSvtlWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
47-240 1.50e-17

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 83.67  E-value: 1.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLMLLTVFGNVLVIIaVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSG 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqppAEPRCEIN 206
Cdd:PHA03087 117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHE----TLICCMFY 192
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 207 DQK------WYVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:PHA03087 193 NNKtmnwklFINFEINIIGMLIPLTILLYCYSKILITLKG 232
 
Name Accession Description Interval E-value
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
49-452 1.47e-162

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 459.41  E-value: 1.47e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqpPAEPRCEINDQ 208
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQ----PEGPICKINDE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptql 288
Cdd:cd15322  157 KWYIISSCIGSFFAPCLIMVLVYIRIYQIAK------------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 289 ngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeer 368
Cdd:cd15322      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 369 gggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15322  188 -------------NREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVcDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHD 254

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15322  255 FRRAF 259
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
49-452 7.94e-143

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 409.04  E-value: 7.94e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgssGGQPPAEPRCEINDQ 208
Cdd:cd15059   81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDE---QPWHGAEPQCELSDD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptql 288
Cdd:cd15059  158 PGYVLFSSIGSFYIPLLIMIIVYARIYRAAKR------------------------------------------------ 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 289 ngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeer 368
Cdd:cd15059      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 369 gggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVG--CSVPRTLFKFFFWFGYCNSSLNPVIYTIFNH 446
Cdd:cd15059  190 --------------KERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCktCGVPELLFKFFFWLGYCNSALNPVIYTIFNK 255

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15059  256 DFRRAF 261
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
43-452 1.11e-142

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 409.31  E-value: 1.11e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCE 122
Cdd:cd15321    1 YSVQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekKGSSGGQPPAEPR 202
Cdd:cd15321   81 IYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIY---KGKQKDEQGGLPQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 203 CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeae 282
Cdd:cd15321  158 CKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAK------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 283 plptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaa 362
Cdd:cd15321      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 363 gpgeergggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPV 439
Cdd:cd15321  195 -------------------NREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAIcpeLCKVPHSLFQFFFWIGYCNSSLNPV 255
                        410
                 ....*....|...
gi 826349104 440 IYTIFNHDFRRAF 452
Cdd:cd15321  256 IYTIFNQDFRRAF 268
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
51-452 1.54e-141

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 405.86  E-value: 1.54e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15323    3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqppAEPRCEINDQKW 210
Cdd:cd15323   83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGD----VYPQCKLNDETW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15323  159 YILSSCIGSFFAPCLIMILVYIRIYRVAKA-------------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd15323      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15323  189 ------------REKRFTFVLAVVMGVFVVCWFPFFFSYSLYGIcreACEVPEPLFKFFFWIGYCNSSLNPVIYTIFNQD 256

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15323  257 FRRSF 261
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
51-452 2.02e-122

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 357.26  E-value: 2.02e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15324    3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgssggqppaEPRCEINDQKW 210
Cdd:cd15324   83 FCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHD---------EWECLLNDETW 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15324  154 YILSSCTVSFFAPGLIMILVYCKIYRVAKM-------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd15324      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15324  184 ------------REKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVcrkRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRD 251

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15324  252 FRKAF 256
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-452 1.74e-97

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 293.70  E-value: 1.74e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqPPAEPRCEINDQK 209
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQP---SVVDCECEFTPNK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqln 289
Cdd:cd14967  158 IYVLVSSVISFFIPLLIMIVLYARIFRVAR-------------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerg 369
Cdd:cd14967      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA--VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd14967  188 -------------RELKAAKTLAIIVGAFLLCWLPFFIIYLVSAfcPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRD 254

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd14967  255 FRRAF 259
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
54-452 7.32e-76

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 238.00  E-value: 7.32e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15064    6 LLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQPPAEPRCEINDQKWYVI 213
Cdd:cd15064   86 ASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLF-----GWRTPDSEDPSECLISQDIGYTI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15064  161 FSTFGAFYIPLLLMLILYWKIYRAAA------------------------------------------------------ 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggak 373
Cdd:cd15064      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 asrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15064  187 ---------RERKAAKTLGIILGAFIVCWLPFFLVALIVPLcsHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257

                 .
gi 826349104 452 F 452
Cdd:cd15064  258 F 258
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
54-452 7.94e-75

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 235.63  E-value: 7.94e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15329    6 VLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppaeprCEINDQKWYVI 213
Cdd:cd15329   86 ASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGV------CQVSQDFGYQI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15329  160 YATFGAFYIPLIVMLVLYYKIYRAAK------------------------------------------------------ 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggak 373
Cdd:cd15329      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 asrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGC-----SVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd15329  186 ---------SERKAIKTLGIIMGAFTLCWLPFFILALLRPFLKpikcsCIPLWLSRLFLWLGYANSFLNPIIYAKFNREF 256

                 ....
gi 826349104 449 RRAF 452
Cdd:cd15329  257 RTPF 260
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
54-452 1.73e-73

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 233.40  E-value: 1.73e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15065    5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCST 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL------ISIEKKGSSGGQPPAEPRCEIND 207
Cdd:cd15065   85 ASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIhlgwhrLSQDEIKGLNHASNPKPSCALDL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 208 QKWY-VISSCIgSFFAPCLIMILVYVRIYQIA-------KRRTRVPPSRRGPdaaTAPPGGTERRPNGLSpgrgaglaga 279
Cdd:cd15065  165 NPTYaVVSSLI-SFYIPCLVMLLIYSRLYLYArkhvvniKSQKLPSESGSKF---QVPSLSSKHNNQGVS---------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 280 eaeplptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgaga 359
Cdd:cd15065      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 360 paagpgeerggGAKASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLNP 438
Cdd:cd15065  231 -----------DHKAAV-------------TLGIIMGVFLICWLPFFIINIIAAFcKTCIPPKCFKILTWLGYFNSCLNP 286
                        410
                 ....*....|....
gi 826349104 439 VIYTIFNHDFRRAF 452
Cdd:cd15065  287 IIYSIFNSEFRRAF 300
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
51-452 8.44e-72

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 227.70  E-value: 8.44e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15060    3 TTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDIL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKkgSSGGQPPAEPrCEINDQKW 210
Cdd:cd15060   83 CCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWND--WPENFTETTP-CTLTEEKG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQiakrrtrvppsrrgpdaATAppggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15060  160 YVIYSSSGSFFIPLLIMTIVYVKIFI-----------------ATS---------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd15060      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd15060  189 ------------KERRAARTLGIIMGVFVVCWLPFFLMYVILPFceTCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDF 256

                 ....
gi 826349104 449 RRAF 452
Cdd:cd15060  257 RRAF 260
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
53-452 5.34e-70

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 224.62  E-value: 5.34e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  53 CLVGLLMLLTVFGNVLVIIAVFTSRALKAP-QNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKaWCEIYLALDVLF 131
Cdd:cd15057    5 CILYLLVLLTLLGNALVIAAVLRFRHLRSKvTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS---IEKKGSSGGQPPAEPR-CEIND 207
Cdd:cd15057   84 STASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLgwhRADDTSEALALYADPCqCDSSL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgRGAGLAGAEAEplptq 287
Cdd:cd15057  164 NRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIR----------------------------RIAALERAAQE----- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 288 lngapgepapagpreadaldleessssehaerppgprrpergprAQGKARASqvkpggslprrgpgptgagapaagpgee 367
Cdd:cd15057  211 --------------------------------------------STNPDSSL---------------------------- 218
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 368 rgggakasrwRGRQNREKRFTFVLAVVIGVFVVCWFPFF-------FTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVI 440
Cdd:cd15057  219 ----------RSSLRRETKALKTLSIIMGVFVCCWLPFFilncvlpFCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPII 288
                        410
                 ....*....|..
gi 826349104 441 YTiFNHDFRRAF 452
Cdd:cd15057  289 YA-FNADFRKAF 299
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
49-452 1.27e-68

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 220.28  E-value: 1.27e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPR-CEIND 207
Cdd:cd15051   81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNGDTPNqCRFEL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAkrRTRVppsrrgpdaatappggteRRPNGLSPGRGAglagaeaeplptq 287
Cdd:cd15051  161 NPPYVLLVAIGTFYLPLLIMCGVYLRIFRIA--REQA------------------KRINALTPASTA------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 288 lngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgee 367
Cdd:cd15051      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 368 rgggakASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNH 446
Cdd:cd15051  208 ------NSSKSAATAREHKATVTLAAVLGAFIICWFPYFTYFTYRGLcGDNINETALSVVLWLGYANSALNPILYAFLNR 281

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15051  282 DFRRAF 287
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
51-452 1.98e-67

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 216.45  E-value: 1.98e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDV 129
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGgYWLFGRDWCDVWHSFDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIekKGSSGGQPPAEPRCEINDQK 209
Cdd:cd15067   82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWW--RAVDPGPSPPNQCLFTDDSG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIgSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqln 289
Cdd:cd15067  160 YLIFSSCV-SFYIPLVVMLFTYYRIYRAAA-------------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerg 369
Cdd:cd15067      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSV----PRTLFKFFFWFGYCNSSLNPVIYTIFN 445
Cdd:cd15067  189 -------------KEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNcvsnPDILFPLVTWLGYINSGMNPIIYACSS 255

                 ....*..
gi 826349104 446 HDFRRAF 452
Cdd:cd15067  256 RDFRRAF 262
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
57-452 3.43e-66

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 213.36  E-value: 3.43e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15053    9 LLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMCSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEkkgSSGGQPPAEPRCEINDqkwYVISS 215
Cdd:cd15053   89 IFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLN---NVPYRDPEECRFYNPD---FIIYS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 216 CIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapgep 295
Cdd:cd15053  163 SISSFYIPCIVMLLLYYRIFRALR-------------------------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 296 apagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggakas 375
Cdd:cd15053      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 376 rwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-------GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd15053  187 -------REKKATKTLAIVLGVFLFCWLPFFTLNILNAIcpklqnqSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEF 259

                 ....
gi 826349104 449 RRAF 452
Cdd:cd15053  260 RKAF 263
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
56-452 4.40e-63

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 205.30  E-value: 4.40e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15066    7 TLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPP----LISIEKKGSSGGQPPAEprCEINDQKWY 211
Cdd:cd15066   87 ILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPiflgWYTTEEHLQYRKTHPDQ--CEFVVNKIY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 212 -VISSCIgSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggtERrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15066  165 aLISSSV-SFWIPCIVMIFTYYRIYLEAKR---------------------EH--------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd15066      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gaKASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15066  196 --KAAK-------------TLGIIMGAFILCWLPFFLWYVTTTLcgdACPYPPILVSILFWIGYFNSTLNPLIYAYFNRD 260

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15066  261 FREAF 265
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
51-445 9.70e-63

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 204.83  E-value: 9.70e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKW 210
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAATAppggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd00637  161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRR---------------------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd00637      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 371 gakasrwrgRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVG---CSVPRTLFKFFFWFGYCNSSLNPVIYTIFN 445
Cdd:cd00637  207 ---------RRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGpdpSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
49-452 2.28e-62

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 203.50  E-value: 2.28e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKG----SSGGQPPAEPRCE 204
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKdgimDYSGSSSLPCTCE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 INDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAkrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaepl 284
Cdd:cd15063  161 LTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAA---------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 285 ptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagp 364
Cdd:cd15063      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 365 geergggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTI 443
Cdd:cd15063  195 -----------------RMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAfCEDCIPPLLFSVFFWLGYCNSALNPCIYAL 257

                 ....*....
gi 826349104 444 FNHDFRRAF 452
Cdd:cd15063  258 FSRDFRFAF 266
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
54-452 1.86e-61

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 201.04  E-value: 1.86e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15331    6 ILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQaIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSgGQPPAEPRCEINDQKWYVI 213
Cdd:cd15331   86 ASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDL-DRVLKTGVCLISQDYGYTI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggtERrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15331  164 FSTVGAFYVPLLLMIIIYWKIYQAAKR---------------------ER------------------------------ 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggaK 373
Cdd:cd15331  193 -------------------------------------------------------------------------------K 193
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 ASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFtYTLTAVGC---SVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15331  194 AAR-------------TLAIITGAFVVCWLPFFL-VALVMPFCgawQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRG 259

                 ..
gi 826349104 451 AF 452
Cdd:cd15331  260 AF 261
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-452 6.27e-59

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 194.12  E-value: 6.27e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppaepRCEINDQK 209
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLG-----SCYYTYDK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIYQIAkrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqln 289
Cdd:cd15061  156 GYRIYSSMGSFFLPLLLMLFVYLRIFRVI--------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerg 369
Cdd:cd15061      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd15061  185 ------------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPfCDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKDF 252

                 ....
gi 826349104 449 RRAF 452
Cdd:cd15061  253 RRAF 256
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
54-452 1.05e-55

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 186.61  E-value: 1.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15055    6 VLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKWYVI 213
Cdd:cd15055   86 ASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNSCYGECVVVVNFIWGV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15055  166 VDLVLTFILPCTVMIVLYMRIFVVARS----------------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraQGKARASQVKPGGSLprrgpgptgagapaagpgeerGGGAK 373
Cdd:cd15055  193 ---------------------------------------QARAIRSHTAQVSLE---------------------GSSKK 212
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 374 ASRwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTyTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15055  213 VSK-----KSERKAAKTLGIVVGVFLLCWLPYYIV-SLVDPYISTPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-441 5.34e-55

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.04  E-value: 5.34e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104   65 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFCTSSIVHLCAIS 143
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  144 LDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppaEPRCEIN------DQKWYVISSCI 217
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDfpedlsKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  218 GSFFAPCLIMILVYVRIYQIAKRRtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapgepap 297
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKS-------------------------------------------------------- 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  298 agpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggAKASRW 377
Cdd:pfam00001 182 --------------------------------------------------------------------------ASKQKS 187
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104  378 RGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFF---WFGYCNSSLNPVIY 441
Cdd:pfam00001 188 SERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLalDCELSRLLDKALSvtlWLAYVNSCLNPIIY 256
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
51-452 6.31e-55

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 185.35  E-value: 6.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15058    3 LLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPlisIEKKGSSGGQPPA-----EPR-CE 204
Cdd:cd15058   83 CVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVP---IMNQWWRANDPEAndcyqDPTcCD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 INDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGpdaatappggteRRPNGLSPgrgaglagaeaepl 284
Cdd:cd15058  160 FRTNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKRRL------------RFQSECPA-------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 285 ptqlngaPGEPAPAGPReadaldleessssehaerppgprrpergpraqgkarasqvkpggSLPRRGPGPTGAgapaagp 364
Cdd:cd15058  214 -------PQTTSPEGKR--------------------------------------------SSGRRPSRLTVV------- 235
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 365 geergggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR-TLFKFFFWFGYCNSSLNPVIYTi 443
Cdd:cd15058  236 ------------------KEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPgEVFLLLNWLGYINSGLNPIIYC- 296

                 ....*....
gi 826349104 444 FNHDFRRAF 452
Cdd:cd15058  297 RSPEFRTAF 305
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
45-452 9.62e-55

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 183.46  E-value: 9.62e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15333    1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqppAEPRCE 204
Cdd:cd15333   81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEE-----EVSECV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 IN-DQKWYVISSCIGSFFAPCLIMILVYVRIYQiakrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaep 283
Cdd:cd15333  156 VNtDHILYTVYSTVGAFYIPTLLLIALYGRIYV----------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 284 lptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgKARAsqvkpggslprrgpgptgagapaag 363
Cdd:cd15333  189 ---------------------------------------------------EARA------------------------- 192
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 364 pgeergggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPVI 440
Cdd:cd15333  193 -------------------RERKATKTLGIILGAFIVCWLPFFIISLVLPIckdACWFHLAIFDFFTWLGYLNSLINPII 253
                        410
                 ....*....|..
gi 826349104 441 YTIFNHDFRRAF 452
Cdd:cd15333  254 YTMSNEDFKQAF 265
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
54-452 2.04e-54

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 182.51  E-value: 2.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFC 132
Cdd:cd15052    6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGgVWPLPLVLCLLWVTLDVLFC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP-PLISIEKKGSSggqpPAEPRCEINDqKWY 211
Cdd:cd15052   86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPiPVLGIIDTTNV----LNNGTCVLFN-PNF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 212 VISSCIGSFFAPCLIMILVY-VRIYQIAKRRtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15052  161 VIYGSIVAFFIPLLIMVVTYaLTIRLLSNEQ------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd15052      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gaKASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFTYTLTAVG----CSVPRTLFKFFFWFGYCNSSLNPVIYTIFNH 446
Cdd:cd15052  192 --KASK-------------VLGIVFAVFVICWCPFFITNILTGLCeecnCRISPWLLSVFVWLGYVSSTINPIIYTIFNK 256

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15052  257 TFRRAF 262
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
54-452 1.54e-52

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 178.20  E-value: 1.54e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15314    6 FLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS-IEKKGSSGGQPPAEPRCEINDQKWYV 212
Cdd:cd15314   86 ASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLeLNIKGIYYNHVACEGGCLVFFSKVSS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 213 ISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGpdaatappggterrpnglspgrgaglagaeaeplptqlngap 292
Cdd:cd15314  166 VVGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSART------------------------------------------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 293 gepapagpreadaldleessssehaerppgprrpergpraqgkarasqvKPGGSLprrgpgptgagapaagpgeerggga 372
Cdd:cd15314  204 -------------------------------------------------KSGASS------------------------- 209
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 kasrwrgrQNREKRFTFVLAVVIGVFVVCWFPFFF-TYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15314  210 --------SKMERKATKTLAIVMGVFLLCWTPFFLcNIIDPFINYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKA 281

                 .
gi 826349104 452 F 452
Cdd:cd15314  282 F 282
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
57-452 1.31e-51

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 175.16  E-value: 1.31e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15310    9 ALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTgGVWNFSRICCDVFVTLDVMMCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTP---RRIKAIIVTVWVISAVISFPPLISIekkgSSGGQPPAeprCEINDQKwYV 212
Cdd:cd15310   89 ILNLCAISIDRYTAVVMPVHYQHGTGQsscRRVSLMITAVWVLAFAVSCPLLFGF----NTTGDPTV---CSISNPD-FV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 213 ISSCIGSFFAPCLIMILVYVRIYQIAkrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngap 292
Cdd:cd15310  161 IYSSVVSFYLPFGVTLLVYVRIYVVL------------------------------------------------------ 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 293 gepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerggga 372
Cdd:cd15310      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 kasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA--VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15310  187 ---------LREKKATQMLAIVLGAFIVCWLPFFLTHILNThcQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257

                 ..
gi 826349104 451 AF 452
Cdd:cd15310  258 AF 259
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
53-452 1.09e-50

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 174.81  E-value: 1.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  53 CLVGLLMLLTVFGNVLVIIAVFTSRALKAP-QNLFLVSLASADILVATLVIPFSLANEVMGYWYFGkAWCEIYLALDVLF 131
Cdd:cd15320    6 CFLSVLILSTLLGNTLVCAAVIRFRHLRSKvTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL-ISIEK-------KGSSGGQPPAEPRC 203
Cdd:cd15320   85 STASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKakptsflDLNASLRDLTMDNC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 204 EINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgRGAGLAGAeaep 283
Cdd:cd15320  165 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIR----------------------------RISALERA---- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 284 lptqlngapgepapagpreadaldleesssSEHAerppgprrpergpraqgKARASQVKPGGSLPRRGPgptgagapaag 363
Cdd:cd15320  213 ------------------------------AVHA-----------------KNCQNSTGNRGSGDCQQP----------- 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 364 pgeergggakASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFF--------TYTLTAVGCSVPRTlFKFFFWFGYCNSS 435
Cdd:cd15320  235 ----------ESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFIlncmvpfcKPTSTEPFCISSTT-FDVFVWFGWANSS 303
                        410
                 ....*....|....*..
gi 826349104 436 LNPVIYTiFNHDFRRAF 452
Cdd:cd15320  304 LNPIIYA-FNADFRKAF 319
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
49-452 4.57e-50

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 172.29  E-value: 4.57e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSIT-QAIEYnlKRTPRRIKAIIVTVWVISAVISFPPL------ISIEKKGSSGGqPPAEP 201
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICcQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPImqgwnhIGIEDLIAFNC-ASGST 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 202 RCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSrrgpdaatappggterrpnglspgrgaglagaea 281
Cdd:cd15056  158 SCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRS---------------------------------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 282 eplptqLNGAPGEPAPAGPReadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapa 361
Cdd:cd15056  204 ------LQRAGSSNHEADQH------------------------------------------------------------ 217
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 362 agpgeergggaKASRWRgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVI 440
Cdd:cd15056  218 -----------RNSRMR----TETKAAKTLGIIMGCFCVCWAPFFVTNIVDPfIGYRVPYLLWTAFLWLGYINSGLNPFL 282
                        410
                 ....*....|..
gi 826349104 441 YTIFNHDFRRAF 452
Cdd:cd15056  283 YAFFNKSFRRAF 294
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
54-452 9.00e-50

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 170.46  E-value: 9.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15326    6 VLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQPPAEPRCEINDQKWYVI 213
Cdd:cd15326   86 ASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLL-----GWKEPAPPDDKVCEITEEPFYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKRRTrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15326  161 FSSLGSFYIPLIVILVMYCRVYIVALKFS--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggak 373
Cdd:cd15326      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 asrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSV--PRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15326  190 ---------REKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLkpPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRA 260

                 .
gi 826349104 452 F 452
Cdd:cd15326  261 F 261
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
49-452 1.20e-49

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 169.98  E-value: 1.20e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQPPAEPRCEINDQ 208
Cdd:cd15062   81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL-----GWKEPAPADEQACGVNEE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptql 288
Cdd:cd15062  156 PGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKFS---------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 289 ngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeer 368
Cdd:cd15062      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 369 gggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNH 446
Cdd:cd15062  190 --------------REKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLfsTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSR 255

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15062  256 EFKRAF 261
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
54-452 4.99e-49

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 168.62  E-value: 4.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15330    6 FLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQPPAEPR-CEINDQKWYV 212
Cdd:cd15330   86 SSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML-----GWRTPEDRSDPDaCTISKDPGYT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 213 ISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngap 292
Cdd:cd15330  161 IYSTFGAFYIPLILMLVLYGRIFKAAA----------------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 293 gepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerggga 372
Cdd:cd15330      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 kasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFF---FTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFR 449
Cdd:cd15330  188 ----------RERKTVKTLGIIMGTFILCWLPFFivaLVLPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQ 257

                 ...
gi 826349104 450 RAF 452
Cdd:cd15330  258 SAF 260
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
45-452 6.30e-49

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 168.18  E-value: 6.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVclvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15335    1 MLIVLTLA----LITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqPPAEPRCE 204
Cdd:cd15335   77 LSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDAN---IPSQCIIQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 iNDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggtERrpnglspgrgaglagaeaepl 284
Cdd:cd15335  154 -HDHVIYTIYSTFGAFYIPLTLILILYYRIYHAASR---------------------ER--------------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 285 ptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagp 364
Cdd:cd15335      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 365 geergggaKASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFTYTLTAVG-CSVPRTLFKFFFWFGYCNSSLNPVIYTI 443
Cdd:cd15335  191 --------KAAR-------------ILGLILGAFILSWLPFFIKELIVGLSvMTVSPEVADFLTWLGYVNSLVNPLLYTS 249

                 ....*....
gi 826349104 444 FNHDFRRAF 452
Cdd:cd15335  250 FNEDFKLAF 258
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
53-452 1.27e-47

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 166.67  E-value: 1.27e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  53 CLVGLLMLLTVFGNVLVIIAVFTSRALKAP-QNLFLVSLASADILVATLVIPFSLANEVMGYWYFGkAWCEIYLALDVLF 131
Cdd:cd15319    5 CLLSLLILWTLLGNILVCAAVVRFRHLRSKvTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSS----GGQPPAEPR----- 202
Cdd:cd15319   84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGddwvGLHNSSISRqveen 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 203 CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgRGAGLAGAeAE 282
Cdd:cd15319  164 CDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIR----------------------------RISSLERA-AE 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 283 plptqlngapgepapagpreadaldleesssseHAERPpgprrpergpraqgKARASQVKPGGSLprrgpgptgagapaa 362
Cdd:cd15319  215 ---------------------------------HAQSC--------------RSNRIDCHHHTSL--------------- 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 363 gpgeergggakasrwRGRQNREKRFTFVLAVVIGVFVVCWFPFFFtytltaVGCSVP-----------------RTLFKF 425
Cdd:cd15319  233 ---------------RTSIKKETKVLKTLSVIMGVFVCCWLPFFI------LNCMVPfcdrppadpdaglpcvsETTFDV 291
                        410       420
                 ....*....|....*....|....*..
gi 826349104 426 FFWFGYCNSSLNPVIYTiFNHDFRRAF 452
Cdd:cd15319  292 FVWFGWANSSLNPIIYA-FNADFRKVF 317
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
47-453 4.73e-47

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 163.20  E-value: 4.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLvclvGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15334    3 ISLTL----SILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqppaEPRCEI- 205
Cdd:cd15334   79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSR------EDECIIk 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAkrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplp 285
Cdd:cd15334  153 HDHIVFTIYSTFGAFYIPLALILILYYKIYRAA----------------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 286 tqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpg 365
Cdd:cd15334      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 366 eergggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTI 443
Cdd:cd15334  186 ----------------TRERKAATTLGLILGAFVICWLPFFVKEVIVNTcdSCYISEEMSNFLTWLGYINSLINPLIYTI 249
                        410
                 ....*....|
gi 826349104 444 FNHDFRRAFK 453
Cdd:cd15334  250 FNEDFKKAFQ 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
59-452 9.09e-47

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 163.29  E-value: 9.09e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  59 MLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVH 138
Cdd:cd15312   11 ILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 139 LCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISieKKGSSGGQP-PAEPRCE-----INDQKWYV 212
Cdd:cd15312   91 LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFS--EVNLEGIEDyVALVSCTgscvlIFNKLWGV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 213 ISSCIGsFFAPCLIMILVYVRIYQIAKRRTRVppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqLNGAP 292
Cdd:cd15312  169 IASLIA-FFIPGTVMIGIYIKIFFVARKHAKV-------------------------------------------INNRP 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 293 GEPAPAGPREADAldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerggga 372
Cdd:cd15312  205 SVTKGDSKNKLSK------------------------------------------------------------------- 217
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 kasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTyTLTA--VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15312  218 ---------KKERKAAKTLSIVMGVFLLCWLPFFVA-TLIDpfLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQK 287

                 ..
gi 826349104 451 AF 452
Cdd:cd15312  288 AF 289
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
54-452 3.32e-46

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 161.23  E-value: 3.32e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15327    6 FLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQPPAEPRCEINDQKWYVI 213
Cdd:cd15327   86 ASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLL-----GWKEPPPPDESICSITEEPGYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKRRTrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15327  161 FSSLFSFYLPLMVILVMYFRVYVVALKFS--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggak 373
Cdd:cd15327      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 asrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRT--LFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15327  190 ---------REKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALKPSemVFKVIFWLGYFNSCVNPIIYPCSSKEFKRA 260

                 .
gi 826349104 452 F 452
Cdd:cd15327  261 F 261
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
50-452 8.79e-46

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 160.93  E-value: 8.79e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15048    2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKkgSSGGQPPAEPRCEIN--D 207
Cdd:cd15048   82 TLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDL--WTGYSIVPTGDCEVEffD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggteRRPNGLSPGRGAGLAGAEAEPLPTQ 287
Cdd:cd15048  160 HFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSR-------------------RRPLRSVPILPASQNPSRARSQREQ 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 288 LNGApgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgee 367
Cdd:cd15048  221 VKLR---------------------------------------------------------------------------- 224
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 368 rgggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPF-FFTYTLTAVGCS-VPRTLFKFFFWFGYCNSSLNPVIYTIFN 445
Cdd:cd15048  225 ---------------RDRKAAKSLAILVLVFLICWAPYtILTIIRSFCSGScVDSYLYEFTFWLLWTNSAINPFLYAACH 289

                 ....*..
gi 826349104 446 HDFRRAF 452
Cdd:cd15048  290 PRFRKAF 296
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-452 1.28e-45

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 160.84  E-value: 1.28e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPA---EPR-CEINDQK 209
Cdd:cd15959   86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEEAQRcydNPRcCDFVTNM 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgrgagLAGAEAEPLPtqln 289
Cdd:cd15959  166 PYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVR--------------------------------LIRKDKVRFP---- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gaPGEPAPAGPReadaldleessssehaerppgprrpergpraqgkaRASQVKPGGSLPRrgpgptgagapaagpgeerg 369
Cdd:cd15959  210 --PEESPPAESR-----------------------------------PACGRRPSRLLAI-------------------- 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS-VPRTLFKFFFWFGYCNSSLNPVIYTiFNHDF 448
Cdd:cd15959  233 -------------KEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRSlVPDPAFLFLNWLGYANSAFNPIIYC-RSPDF 298

                 ....
gi 826349104 449 RRAF 452
Cdd:cd15959  299 RSAF 302
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
49-452 3.25e-45

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 159.15  E-value: 3.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFpPLISI----EKKGSSGGQPPAEPRCE 204
Cdd:cd15317   81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTF-GLIYTgandEGLEEYSSEISCVGGCQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 INDQKWYVISSCIgSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgrgaglagaeaepl 284
Cdd:cd15317  160 LLFNKIWVLLDFL-TFFIPCLIMIGLYAKIFLVARRQAR----------------------------------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 285 ptqlngapgepapagpreadaldleessssehaerppgprrpergpRAQGKARASQVKpggslprrgpgptgagapaagp 364
Cdd:cd15317  198 ----------------------------------------------KIQNMEDKFRSS---------------------- 209
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 365 geergggaKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTI 443
Cdd:cd15317  210 --------EENSSKASASRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEySNFITPAIVFDAVIWLGYFNSAFNPFIYAF 281

                 ....*....
gi 826349104 444 FNHDFRRAF 452
Cdd:cd15317  282 FYPWFRKAF 290
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-452 2.29e-44

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 157.37  E-value: 2.29e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15958    6 LMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS--IEKKGSSGGQPPAEPR-CEINDQKW 210
Cdd:cd15958   86 ASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMhwWRDEDDQALKCYEDPGcCDFVTNRA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15958  166 YAIASSIISFYIPLLIMIFVYLRVYREAKKQIK----------------------------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpeRGPRAQGKARASQVKPGGSLPRRGPGPTGAgapaagpgeergg 370
Cdd:cd15958  199 -------------------------------------KIDKCEGRFHNTLTGLGRKCKRRPSRILAL------------- 228
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS-VPRTLFKFFFWFGYCNSSLNPVIYTiFNHDFR 449
Cdd:cd15958  229 ------------REQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRElVPDWLFVFFNWLGYANSAFNPIIYC-RSPDFR 295

                 ...
gi 826349104 450 RAF 452
Cdd:cd15958  296 KAF 298
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
54-452 1.08e-43

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 154.04  E-value: 1.08e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15309    6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLK-RTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqppaepRCEInDQKWYV 212
Cdd:cd15309   86 ASILNLCAISIDRYTAVAMPMLYNTRySSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQN--------ECII-ANPAFV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 213 ISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngap 292
Cdd:cd15309  157 VYSSIVSFYVPFIVTLLVYVQIYIVLQ----------------------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 293 gepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerggga 372
Cdd:cd15309      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 kasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15309  184 ----------KEKKATQMLAIVLGVFIICWLPFFITHILnMHCDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKA 253

                 .
gi 826349104 452 F 452
Cdd:cd15309  254 F 254
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
51-452 2.06e-43

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 153.57  E-value: 2.06e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRAL-KAPQNLfLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALD 128
Cdd:cd15328    3 VLTLLAMLVVATFLWNLLVLVTILRVRTFhRVPHNL-VASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISFD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLkRTPRRIKAIIVTV-WVISAVISFPPLISiekkGSSGGQPPAEPRCEIND 207
Cdd:cd15328   82 VLCCTASIWNVTAIALDRYWSITRHLEYTL-RTRRRISNVMIALtWALSAVISLAPLLF----GWGETYSEDSEECQVSQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptq 287
Cdd:cd15328  157 EPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAQ------------------------------------------------ 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 288 lngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgee 367
Cdd:cd15328      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 368 rgggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNH 446
Cdd:cd15328  189 ---------------KEKRAALMVGILIGVFVLCWIPFFLTELISPLcSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNK 253

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15328  254 NYNNAF 259
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
54-452 2.26e-43

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 153.51  E-value: 2.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15325    6 ILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQPPAEPRCEINDQKWYVI 213
Cdd:cd15325   86 ASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLF-----GWKEPAPEDETICQITEEPGYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SSCIGSFFAPCLIMILVYVRIYQIAKRRTrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapg 293
Cdd:cd15325  161 FSALGSFYLPLAIILVMYCRVYVVALKFS--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 294 epapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggak 373
Cdd:cd15325      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 asrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15325  190 ---------REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIfpAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKA 260

                 .
gi 826349104 452 F 452
Cdd:cd15325  261 F 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
51-244 3.09e-41

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 147.85  E-value: 3.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLV-GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15049    2 LICIAtGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKkgSSGGQPPAEPRCEIN--D 207
Cdd:cd15049   82 VASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQY--FVGERTVPDGQCYIQflD 159
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 826349104 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15049  160 DPAITFGTAIAAFYLPVLVMTILYWRIYRETARERKA 196
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-241 1.79e-39

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 144.24  E-value: 1.79e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15957    6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPlisIEKKGSSGGQPPA------EPRCEIND 207
Cdd:cd15957   86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLP---IQMHWYRATHQEAincyaeETCCDFFT 162
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd15957  163 NQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQ 196
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
50-452 5.15e-39

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 142.74  E-value: 5.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI--SIEKKGSSGGQPPAEPRC---- 203
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVvyELEEIISSEPGTITIYICtedw 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 204 -EINDQKWYVISSCIGSFFAPCLIMILVYVRI-YQIAKRrtrvppsrrgpdaatAPPGGTERRPnglspgrgaglagaea 281
Cdd:cd14993  162 pSPELRKAYNVALFVVLYVLPLLIISVAYSLIgRRLWRR---------------KPPGDRGSAN---------------- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 282 eplptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapa 361
Cdd:cd14993      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 362 agpgeergggakaSRWRGRQNREK-RFTFVLAVVIGVFVVCWFPFF-------FTYTLTAVGCSVPRTLFKFFFWFGYCN 433
Cdd:cd14993  211 -------------STSSRRILRSKkKVARMLIVVVVLFALSWLPYYvlsilldFGPLSSEESDENFLLILPFAQLLGYSN 277
                        410
                 ....*....|....*....
gi 826349104 434 SSLNPVIYTIFNHDFRRAF 452
Cdd:cd14993  278 SAINPIIYCFMSKKFRRGF 296
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
49-452 1.46e-38

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 140.74  E-value: 1.46e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLAL 127
Cdd:cd15308    2 AALVGGV-LLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGgVWTLSPVLCDALMTM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEkkgSSGGQPPAEPRCEIND 207
Cdd:cd15308   81 DVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLN---NVPNRDPAVCKLEDNN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 208 qkwYVISSCIGSFFAPCLIMILVYVRIYqiakrrtrvppsrrgpdaatappggterrpnglspgRGAGlagaeaeplptq 287
Cdd:cd15308  158 ---YVVYSSVCSFFIPCPVMLVLYCAMF------------------------------------RGLG------------ 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 288 lngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgee 367
Cdd:cd15308      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 368 rgggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFN 445
Cdd:cd15308  187 ---------------RERKAMRVLPVVVGAFLFCWTPFFVVHITRALceSCSIPPQLISIVTWLGYVNSALNPVIYTVFN 251

                 ....*..
gi 826349104 446 HDFRRAF 452
Cdd:cd15308  252 AEFRNVF 258
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
54-452 1.76e-37

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 138.11  E-value: 1.76e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFC 132
Cdd:cd15305    6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYaWPLPRYLCPIWISLDVLFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNlkRTPRRIKAI--IVTVWVISAVISFP-PLISIEKKgssgGQPPAEPRCEINDQK 209
Cdd:cd15305   86 TASIMHLCAISLDRYVAIRNPIEHS--RFNSRTKAMmkIAAVWTISIGISMPiPVIGLQDD----EKVFVNGTCVLNDEN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIgSFFAPCLIMILVYVRIYQIAKRRTRVppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqln 289
Cdd:cd15305  160 FVLIGSFV-AFFIPLIIMVITYCLTIQVLQRQQAI--------------------------------------------- 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerg 369
Cdd:cd15305      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFT---YTLTAVGC--SVPRTLFKFFFWFGYCNSSLNPVIYTIF 444
Cdd:cd15305  194 ------------NNERRASKVLGIVFFLFLIMWCPFFITnilSVLCKEACdqKLMEELLNVFVWVGYVSSGINPLVYTLF 261

                 ....*...
gi 826349104 445 NHDFRRAF 452
Cdd:cd15305  262 NKTYRRAF 269
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
57-452 2.38e-37

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 137.63  E-value: 2.38e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15054    9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL------ISIEKKGSSGGQPPAEPRCEINDQKW 210
Cdd:cd15054   89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIelgwheLGHERTLPNLTSGTVEGQCRLLVSLP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd15054  169 YALVASCLTFFLPSGAICFTYCRILLAARK-------------------------------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadALdleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd15054  199 --------------AL---------------------------------------------------------------- 200
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gaKASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15054  201 --KASL-------------TLGILLGMFFVTWLPFFVANVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 265

                 ..
gi 826349104 451 AF 452
Cdd:cd15054  266 AL 267
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
57-458 5.84e-36

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 134.31  E-value: 5.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15307    9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqPPAEPRCEINDQKWYVISSC 216
Cdd:cd15307   89 MHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHAS---VLVNGTCQIPDPVYKLVGSI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 217 IgSFFAPCLIMILVY-VRIYQIAKRRTRvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqlngapgep 295
Cdd:cd15307  166 V-CFYIPLGVMLLTYcLTVRLLARQRSR---------------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 296 apagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeergggakas 375
Cdd:cd15307      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 376 rwRGRQNR-EKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS----VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15307  193 --HGRIIRlEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAEceerISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQ 270

                 ....*....
gi 826349104 451 AFKKIL-CR 458
Cdd:cd15307  271 AFKKVLlCR 279
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
51-452 2.78e-35

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 131.78  E-value: 2.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15050    3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL-ISIEKKGSSGGQPPAEPRCEINDQK 209
Cdd:cd15050   83 ASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgWHHFARGGERVVLEDKCETDFHDVT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIYqiakrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqln 289
Cdd:cd15050  163 WFKVLTAILNFYIPSLLMLWFYAKIF------------------------------------------------------ 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gapgepapagpreadaldleesssseHAErppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerg 369
Cdd:cd15050  189 --------------------------KAV--------------------------------------------------- 191
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrqNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVgCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15050  192 ------------NRERKAAKQLGFIMAAFILCWIPYFILFMVIAF-CKncCNENLHMFTIWLGYINSTLNPFIYPLCNEN 258

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15050  259 FKKTF 263
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
47-451 8.09e-34

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 128.44  E-value: 8.09e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGllMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15318    1 LVIYLACAIG--MLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEkkgssggqppaeprCEIN 206
Cdd:cd15318   79 LDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKA--------------VEEG 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 207 DQKWYVISSCIGS----------------FFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappggterrpnglsp 270
Cdd:cd15318  145 LAELLTSVPCVGScqllynklwgwlnfpvFFIPCLIMIGLYVKIFIVAKRQAR--------------------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 271 grgaglagaeaeplptqlngapgepapagpreadaldleessssehaerppgprrpergpraqgkarasQVKPGGSLPRR 350
Cdd:cd15318  198 ---------------------------------------------------------------------AIASLLSDTNG 208
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 351 gpgptgagapaagpgeergggakASRwrgrqnREKRFTFVLAVVIGVFVVCWFPFFF-TYTLTAVGCSVPRTLFKFFFWF 429
Cdd:cd15318  209 -----------------------ASK------RERKAAKTLGIAVGVYLLCWLPFTIdTMVDSLLNFITPPLLFDIIIWF 259
                        410       420
                 ....*....|....*....|..
gi 826349104 430 GYCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15318  260 AYFNSACNPLIYVFSYPWFRKA 281
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
57-250 1.75e-33

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 127.76  E-value: 1.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANeVMGY---WYFgkawCEIYLALDVLFCT 133
Cdd:cd14968    9 LIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILI-SLGLptnFHG----CLFMACLVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGS-SGGQPPAEPRC---EINDQK 209
Cdd:cd14968   84 SSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPlESGCGEGGIQClfeEVIPMD 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG 250
Cdd:cd14968  164 YMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLR 204
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
51-236 4.00e-33

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 125.85  E-value: 4.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd17790    3 IVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKW 210
Cdd:cd17790   83 ASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPI 162
                        170       180
                 ....*....|....*....|....*.
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQ 236
Cdd:cd17790  163 ITFGTAIAAFYLPVTIMIILYWRIYR 188
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
50-264 4.99e-33

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 126.17  E-value: 4.99e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd14969    2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNlKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQP-PAEPRCEIN-- 206
Cdd:cd14969   82 FLGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLFWALPPLF-----GWSSYVPeGGGTSCSVDwy 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 207 DQKW----YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvPPSRRGPDAATAPPGGTERR 264
Cdd:cd14969  156 SKDPnslsYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSK-RAARRKNSAITKRTKKAEKK 216
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
51-243 5.26e-32

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 123.82  E-value: 5.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15316    3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS----------IEKKGSSGGqppae 200
Cdd:cd15316   83 FCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTgvnddgleelVNALNCVGG----- 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 826349104 201 prCEIN-DQKWYVISSCigSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15316  158 --CQIIlNQNWVLVDFL--LFFIPTFAMIILYGKIFLVAKQQAR 197
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
54-231 5.56e-32

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 123.12  E-value: 5.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFC 132
Cdd:cd15304    6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP-PLISIE------KKGSsggqppaeprCEI 205
Cdd:cd15304   86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPiPVFGLQddskvfKEGS----------CLL 155
                        170       180
                 ....*....|....*....|....*.
gi 826349104 206 NDQKWYVISSCIgSFFAPCLIMILVY 231
Cdd:cd15304  156 ADENFVLIGSFV-AFFIPLTIMVITY 180
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
49-255 1.22e-31

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 122.71  E-value: 1.22e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIylaLD 128
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKL---VP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTS---SIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPaePRC 203
Cdd:cd15203   78 SLQGVSifvSTLTLTAIAIDRY----QLIVYPTRPrmSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILP--YCG 151
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 204 EINDQKW--------YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAT 255
Cdd:cd15203  152 YFCTESWpssssrliYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRR 211
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
54-457 6.33e-30

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 117.63  E-value: 6.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFC 132
Cdd:cd15306    6 LILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFeAMWPLPLVLCPIWLFLDVLFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP-PLISIEkkgsSGGQPPAEPRCEINDQ--K 209
Cdd:cd15306   86 TASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPvPIKGIE----TDVDNPNNITCVLTKErfG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplptqln 289
Cdd:cd15306  162 DFILFGSLAAFFTPLAIMIVTYFLTIHALRKQT----------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 290 gapgepapagpreadaldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaagpgeerg 369
Cdd:cd15306      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 370 ggakasrwrgrQNREKRFTFVLAVVIGVFVVCWFPFFFTyTLTAVGC-----SVPRTLFKFFFWFGYCNSSLNPVIYTIF 444
Cdd:cd15306  195 -----------ITNEQRASKVLGIVFFLFLLMWCPFFIT-NITSVLCdscnqTTLQMLMEIFVWIGYVSSGVNPLVYTLF 262
                        410
                 ....*....|....
gi 826349104 445 NHDFRRAFKK-ILC 457
Cdd:cd15306  263 NKTFRDAFGRyITC 276
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
46-236 7.77e-30

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 117.36  E-value: 7.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  46 QVTLtLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYL 125
Cdd:cd15299    2 QVVL-IAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEI 205
Cdd:cd15299   81 SIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPDECFIQF 160
                        170       180       190
                 ....*....|....*....|....*....|.
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRIYQ 236
Cdd:cd15299  161 LSEPIITFGTAIAAFYLPVTIMTILYWRIYK 191
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
49-236 3.95e-29

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 115.12  E-value: 3.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQ 208
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTVPERECQIQFLSE 160
                        170       180
                 ....*....|....*....|....*...
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQ 236
Cdd:cd15300  161 PTITFGTAIAAFYIPVSVMTILYCRIYK 188
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
49-243 1.70e-28

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 113.38  E-value: 1.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS---IEKKGSSggqPPAEPRCEI 205
Cdd:cd15301   81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSwpyIEGKRTV---PAGTCYIQF 157
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 206 NDQKWYV-ISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15301  158 LETNPYVtFGTALAAFYVPVTIMCILYWRIWRETKKRQK 196
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
51-244 4.89e-28

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 111.98  E-value: 4.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15297    3 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEkkGSSGGQPPAEPRCEIN--DQ 208
Cdd:cd15297   83 VSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQ--FIVGGRTVPEGECYIQffSN 160
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15297  161 AAVTFGTAIAAFYLPVIIMTVLYWQISRASSREKKV 196
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
51-249 2.93e-27

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 110.27  E-value: 2.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15296    3 LAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAI-IVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQK 209
Cdd:cd15296   83 LCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLkMVLVWVLAFLLYGPAIISWEYIAGGSIIPEGECYAEFFYNW 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRIY-QIAKRRTRVPPSRR 249
Cdd:cd15296  163 YFLMTASTLEFFTPFISVTYFNLSIYlNIQKRRFRLSRDKK 203
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
54-240 9.34e-26

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 105.60  E-value: 9.34e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFC 132
Cdd:cd15302    6 ITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGdYWPLGWVLCDLWLSVDYTVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFpplISIEKKGSSGGQ----PPAEPRCEINDQ 208
Cdd:cd15302   86 LVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFF---ISIFGWQYFTGQgrslPEGECYVQFMTD 162
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:cd15302  163 PYFNMGMYIGYYWTTLIVMLILYAGIYRAANR 194
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
54-244 1.66e-25

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 105.87  E-value: 1.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLM----LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLA--NEVMGYWYFGKAWCEIYLAL 127
Cdd:cd15337    2 LIGIYIaivgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISD-FGFSAVNGFPLKtiSSFNKKWIWGKVACELYGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEIND 207
Cdd:cd15337   81 GGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCTFDYLSRD 160
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 208 QKWYVISSC--IGSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15337  161 LNNRLFILGlfIFGFLCPLLIIIFCYVNIIRAVRNHEKE 199
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
49-243 5.36e-25

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 104.34  E-value: 5.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15083    1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI-----SIEKKGSSggqppaeprC 203
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgwsryVLEGLLTS---------C 151
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 204 EIN------DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15083  152 SFDylsrddANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEK 197
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
51-452 1.94e-24

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 102.37  E-value: 1.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLlmlltvFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd14970    9 VVCVVGL------TGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDAY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqppaEPRCEIN---- 206
Cdd:cd14970   82 NMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGG----TISCNLQwpdp 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 207 ---DQKWYVISSCIGSFFAPCLIMILVYVRIYQiAKRRTRVPPsrrgpdaatappggterrpnglspgrgaglagaeaep 283
Cdd:cd14970  158 pdyWGRVFTIYTFVLGFAVPLLVITVCYSLIIR-RLRSSRNLS------------------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 284 lptqlngapgepaPAGPREADAldleessssehaerppgprrpergpraqgkarasqvkpggslprrgpgptgagapaag 363
Cdd:cd14970  200 -------------TSGAREKRR---------------------------------------------------------- 208
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 364 pgeergggakasrwrgrqnREKRFTFVLAVVIGVFVVCWFPFF-FTYTLTAVGCSVPRT---LFKFFFWFGYCNSSLNPV 439
Cdd:cd14970  209 -------------------ARRKVTRLVLVVVAVFVVCWLPFHvFQIVRLLIDPPETLTvvgVFLFCIALSYANSCLNPI 269
                        410
                 ....*....|...
gi 826349104 440 IYTIFNHDFRRAF 452
Cdd:cd14970  270 LYAFLDENFRKSF 282
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
56-264 2.19e-24

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 102.31  E-value: 2.19e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15207    8 SLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYnlKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCE-----INDQKW 210
Cdd:cd15207   88 VFTLVAIAVDRYRAVVHPTEP--KLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVefwpsDEYRKA 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRI-YQIAKRRTRVPPSRRGPdaatAPPGGTERR 264
Cdd:cd15207  166 YTTSLFVLCYVAPLLIIAVLYVRIgYRLWFKPVPGGGSASRE----AQAAVSKKK 216
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
57-249 2.46e-24

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 102.32  E-value: 2.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLAnevMGYWYFGKAWCEIYLALDVLFCT-SS 135
Cdd:cd15068    9 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT---ISTGFCAACHGCLFIACFVLVLTqSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEK-------KGSSGGQPPAEPRC---EI 205
Cdd:cd15068   86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNcgqpkegKNHSQGCGEGQVAClfeDV 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR-----TRVPPSRR 249
Cdd:cd15068  166 VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQlkqmeSQPLPGER 214
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
51-244 6.29e-24

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 100.48  E-value: 6.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15298    3 IATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKW 210
Cdd:cd15298   83 VSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPA 162
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15298  163 VTFGTAIAAFYLPVVIMTVLYIHISLASARERKV 196
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
52-452 8.81e-24

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 100.53  E-value: 8.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKA-PQNLFLVSLASADILVAtLVIPFSLANEVMGYWYFG-KAWCEIYLALDV 129
Cdd:cd15104    3 GVILAVLSPLIITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVG-LAIPGLATDELLSDGENTqKVLCLLRMCFVI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQP-----PAEPRce 204
Cdd:cd15104   82 TSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKcsffaAFHPR-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 indqkWYVISSCIGsFFAPCLIMILVYVRIYQIAKrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaepl 284
Cdd:cd15104  160 -----VLLVLSCMV-FFPALLLFVFCYCDILKIAR--------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 285 ptqlngapgepapagpreadaldleessssEHaerppgprrpergprAQGKARASQVKPGGSLPRRGPGPtgagapaagp 364
Cdd:cd15104  189 ------------------------------VH---------------SRAIYKVEHALARQIHPRRTLSD---------- 213
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 365 geergggAKASRwrgrqnrekrftfVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYT 442
Cdd:cd15104  214 -------FKAAR-------------TVAVLIGCFLLSWLPFQITGLVQALcdECKLYDVLEDYLWLLGLCNSLLNPWIYA 273
                        410
                 ....*....|
gi 826349104 443 IFNHDFRRAF 452
Cdd:cd15104  274 FWQKEVRRAL 283
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-247 1.03e-23

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 100.93  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15208    3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRIKAIIVTVWVISAVISFPPLISIEKkgssggQPPAEPRCEIN---- 206
Cdd:cd15208   83 SVSVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMIPQAIVMEC------SRVVPLANKTIlltv 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 207 -DQKW--------YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPS 247
Cdd:cd15208  155 cDERWsdsiyqkvYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTS 204
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
47-254 3.14e-23

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 99.29  E-value: 3.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVClvGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL----ANEVmgyWYFGKAWCE 122
Cdd:cd14997    1 VLVSVVY--GVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALvetwAREP---WLLGEFMCK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPR 202
Cdd:cd14997   76 LVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAV 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 203 CEIN-DQKW---YVISSCIGSFFAPCLIMILVYVRiyqIAKR--RTRVPPSRRGPDAA 254
Cdd:cd14997  156 CRTPaDTFWkvaYILSTIVVFFVVPLAILSGLYSV---ICRRlvGHPALESRRADAAN 210
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
51-234 4.90e-23

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 97.82  E-value: 4.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLML-LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15213    2 TLAILMILMIfVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSsggqPPAEPRC-----E 204
Cdd:cd15213   82 FFVLEGVAILLIISVDRYLIIVQRQD---KLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEF----PPRAPQCvlgytE 154
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 205 INDQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15213  155 SPADRIYVVLLLVAVFFIPFLIMLYSYFCI 184
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
56-234 6.16e-23

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 97.73  E-value: 6.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15001    7 VITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWsitqAIEYNLK----RTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEIN----- 206
Cdd:cd15001   87 VLTLTAISIERYY----VILHPMKaksfCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAwpstl 162
                        170       180
                 ....*....|....*....|....*...
gi 826349104 207 DQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15001  163 YSRLYVVYLAIVIFFIPLIVMTFAYARD 190
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
57-249 7.01e-23

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 97.90  E-value: 7.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15012    8 LVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPR-----CEINDQKWY 211
Cdd:cd15012   88 GILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEicvldREMFNSKLY 167
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 826349104 212 VISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
Cdd:cd15012  168 DTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
47-264 1.81e-22

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 97.04  E-value: 1.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYL 125
Cdd:cd14979    1 VLVTAIYV--AIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYpWAFGDGGCKLYY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKK---GSSGGQPPAEPR 202
Cdd:cd14979   79 FLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQylnGPLPGPVPDSAV 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 203 CEI---NDQKWYVISSCIGSFFA-PCLIMILVYVRIYQIAKRRTRVPPSRRGPDAATAPPGGTERR 264
Cdd:cd14979  159 CTLvvdRSTFKYVFQVSTFIFFVlPMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELSLSQQA 224
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
57-242 2.35e-22

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 96.66  E-value: 2.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL-ANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15392    9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFiALLILQYWPFGEFMCPVVNYLQAVSVFVS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYwsitQAIEYNLKRTPRRIKA--IIVTVWVISAVISFPPLIS---IEKKGSSGGQP-PAEPRCEINDQK 209
Cdd:cd15392   89 AFTLVAISIDRY----VAIMWPLRPRMTKRQAllLIAVIWIFALATALPIAITsrlFEDSNASCGQYiCTESWPSDTNRY 164
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 210 WYVISSCIGSFFAPCLIMILVYVRI-YQIAKRRT 242
Cdd:cd15392  165 IYSLVLMILQYFVPLAVLVFTYTRIgIVVWAKRT 198
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
50-243 3.41e-22

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 95.66  E-value: 3.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15295    2 VLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTP-RRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppAEPRCEINDq 208
Cdd:cd15295   82 LLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGE--CEPEFFSNW- 158
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 826349104 209 kWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15295  159 -YILAITSVLEFLVPVILVAYFNTQIYWSLWKRLR 192
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
51-234 4.97e-22

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 95.65  E-value: 4.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15202    3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRC----- 203
Cdd:cd15202   83 SVHVSAYTLTAIAVDRY----QAIMHPLKPriSKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCledwp 158
                        170       180       190
                 ....*....|....*....|....*....|...
gi 826349104 204 EINDQKWYVISSC--IGSFFAPCLIMILVYVRI 234
Cdd:cd15202  159 ERADLFWKYYDLAlfILQYFLPLLVISFAYARV 191
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
58-234 6.94e-22

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 95.19  E-value: 6.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIV 137
Cdd:cd14992   10 IILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 138 HLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI--SIEKKGSSGGQ--PPAEPRCEINDQ---KW 210
Cdd:cd14992   90 TLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYyaTTEVLFSVKNQekIFCCQIPPVDNKtyeKV 169
                        170       180
                 ....*....|....*....|....
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd14992  170 YFLLIFVVIFVLPLIVMTLAYARI 193
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
50-241 9.49e-22

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 95.00  E-value: 9.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAwceIYLALDV 129
Cdd:cd15069    2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSC---LFLACFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCT-SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKK--GSSGGQPPAEP----- 201
Cdd:cd15069   79 LVLTqSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAmsATNNSTNPADHgtnhs 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 826349104 202 ----RC---EINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd15069  159 ccliSClfeNVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQ 205
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
60-452 1.11e-21

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 94.28  E-value: 1.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANevmgYWYFGKAWCEIYLALDVLFC---TSSI 136
Cdd:cd14972   10 VFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSV----LLVSLTPSPATWLLRKGSLVlslLASA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL------ISIEKKGSSGGQPpaeprceinDQKW 210
Cdd:cd14972   86 YSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVlgwncvLCDQESCSPLGPG---------LPKS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVIsSCIGSFFAPCLIMILVYVRIYQIAKRRTrvppsrrgpdAATAPpggterrpnglspgrgaglagaeaeplptqlng 290
Cdd:cd14972  157 YLV-LILVFFFIALVIIVFLYVRIFWCLWRHA----------NAIAA--------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 291 apgepapagpreadaldleessssehaerppgprrpergprAQGKARASQvkpggslprrgpgptgagapaagpgeergg 370
Cdd:cd14972  193 -----------------------------------------RQEAAVPAQ------------------------------ 201
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 gakasrwrgrQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSV--PRTLFKFFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd14972  202 ----------PSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVcdIQAVFYYFLVLALLNSAINPIIYAFRLKEM 271

                 ....
gi 826349104 449 RRAF 452
Cdd:cd14972  272 RRAV 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
52-234 1.37e-21

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 94.28  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLI--SIEKKGSSGG--------QPPA 199
Cdd:cd15390   84 VAASVFTLMAISIDRY----IAIVHPLRPrlSRRTTKIAIAVIWLASFLLALPQLLysTTETYYYYTGsertvcfiAWPD 159
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 826349104 200 EPRCEINdqKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15390  160 GPNSLQD--FVYNIVLFVVTYFLPLIIMAVAYTRV 192
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
45-234 1.60e-21

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 94.20  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVMGyWYFGKAWCEI 123
Cdd:cd14984    3 LPVLYSLVFLLGLV------GNSLVLLVLLYYRKLRSMTDVYLLNLALADLLfVLTL--PFWAVYAADG-WVFGSFLCKL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqppaEPRC 203
Cdd:cd14984   74 VSALYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENG-----SSIC 148
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 204 EIND-----QKWYVISSC---IGSFFAPCLIMILVYVRI 234
Cdd:cd14984  149 SYDYpedtaTTWKTLLRLlqnILGFLLPLLVMLFCYSRI 187
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
60-240 2.15e-21

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 93.88  E-value: 2.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15074   12 ILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 140 CAISLDRYWSITQAiEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIekkgSSGGQPPAEPRCEINdqkW--------- 210
Cdd:cd15074   92 TAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGW----GSYGPEPFGTSCSID---Wtgasasvgg 163
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 211 --YVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:cd15074  164 msYIISIFIFCYLLPVLIIVFSYVKIIRKVKS 195
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
51-184 2.63e-21

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 93.80  E-value: 2.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15079    3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMM-IKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNlKRTPRRIKAIIVTVWVISAVISFPPL 184
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLNGN-PLTRGKALLLILFIWLYALPWALLPL 134
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
50-184 2.98e-21

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 93.63  E-value: 2.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmllTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15336    5 SVILIIGIT---GMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGA 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL 184
Cdd:cd15336   82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPL 136
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
54-249 3.43e-21

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 93.13  E-value: 3.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15096    6 IFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgsSGGQPPAEPR-CEINDQKWYV 212
Cdd:cd15096   86 ASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVV--SYGFSSEAYSyCTFLTEVGTA 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 213 ISSCIGSFFA-----PCLIMILVYVRIyqIAKRRTRVPPSRR 249
Cdd:cd15096  164 AQTFFTSFFLfsyliPLTLICVLYMLM--LRRLRRQKSPGGR 203
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
52-243 4.91e-21

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 92.82  E-value: 4.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd14986    4 VAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYwsitQAIEYNLKRT--PRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqppaEPRC-EINDQ 208
Cdd:cd14986   84 LFASTYILVSMSLDRY----QAIVKPMSSLkpRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDG----VHQCwSSFYT 155
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 209 KW----YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd14986  156 PWqrkvYITWLATYVFVIPLIILSYCYGRILRTIWIRSR 194
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
51-182 1.36e-20

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 91.63  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCeiYLALDVL 130
Cdd:cd15389    3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMC--HLSRFAQ 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 131 FCTS--SIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15389   81 YCSVyvSTLTLTAIALDRH----RVILHPLKPriTPCQGVVVIAIIWIMASCLSLP 132
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
49-231 1.54e-20

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 91.21  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGNILCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqppAEPRCEINDQ 208
Cdd:cd15090   80 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGS---IDCTLTFSHP 156
                        170       180
                 ....*....|....*....|....*...
gi 826349104 209 KWY---VISSC--IGSFFAPCLIMILVY 231
Cdd:cd15090  157 SWYwenLLKICvfIFAFIMPVLIITVCY 184
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
50-231 2.30e-20

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 90.78  E-value: 2.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15089    8 SVVCVVGLL------GNVLVMYGIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAepRCEINDQK 209
Cdd:cd15089   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVC--MLQFPSPS 158
                        170       180
                 ....*....|....*....|....*..
gi 826349104 210 WY---VISSC--IGSFFAPCLIMILVY 231
Cdd:cd15089  159 WYwdtVTKICvfIFAFVVPILVITVCY 185
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-249 6.09e-20

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 89.44  E-value: 6.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15093    9 VVCLVGLC------GNSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPFLAASNALRHWPFGSVLCRLVLSVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPaeprCEIN---- 206
Cdd:cd15093   82 NMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSA----CNMQwpep 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 207 DQKWY---VISSCIGSFFAPCLIMILVYVRIyqIAKRRT---RVPPSRR 249
Cdd:cd15093  158 AAAWSagfIIYTFVLGFLLPLLIICLCYLLI--VIKVKSaglRAGWQQR 204
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
52-241 6.33e-20

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 89.49  E-value: 6.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15979    4 ILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP-PLISIEKKGSSGGQPP------AEPRCE 204
Cdd:cd15979   84 VSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPyPVYSVTVPVPVGDRPRghqcrhAWPSAQ 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 826349104 205 InDQKWYVISSCIgSFFAPCLIMILVYVRIYQ------IAKRR 241
Cdd:cd15979  164 V-RQAWYVLLLLI-LFFIPGVVMIVAYGLISRelyrglLAKKR 204
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
51-255 1.27e-19

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 88.25  E-value: 1.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMGYWYF-GKAWCEIYLALDV 129
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLAS-LVVLVLFFLLGLTEASSrPQALCYLIYLLWY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsieKKGSSGGQPPAEPRCEIN-DQ 208
Cdd:cd14964   80 GANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLV---GKGAIPRYNTLTGSCYLIcTT 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAT 255
Cdd:cd14964  157 IYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDK 203
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-251 1.32e-19

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 88.65  E-value: 1.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  44 SLQVTLTLVCLVGllmlltVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEI 123
Cdd:cd14999    1 AIGTVLSLMCVVG------VAGNVYTLVVMCLSMRPRASMYVYILNLALAD-LLYLLTIPFYVSTYFLKKWYFGDVGCRL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFPPLISIE----KKGSSGGQPPA 199
Cdd:cd14999   74 LFSLDFLTMHASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRlvtvEDKSGGSKRIC 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 200 EPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRI---YQIAKRRTRVPPSRRGP 251
Cdd:cd14999  153 LPTWSEESYKVYLTLLFSTSIVIPGLVIGYLYIRLarkYWLSQAAASNSSRKRLP 207
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
51-242 3.21e-19

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 87.98  E-value: 3.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVF-GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15403    2 LLAIVMILMIAIGFlGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSsggqPPAEPRC-----E 204
Cdd:cd15403   82 FFVLEGVAILLIISVDRFLIIVQRQD---KLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEV----PARAPQCvlgytE 154
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 826349104 205 INDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRT 242
Cdd:cd15403  155 SPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNA 192
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
49-249 6.89e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 86.92  E-value: 6.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLlmlltvFGNVLVIIaVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-------YWYFGKAWC 121
Cdd:cd14978    7 LPVICIFGI------IGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADysssflsYFYAYFLPY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 122 EIYLALdvLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL--ISIEKKGSSGGQPPA 199
Cdd:cd14978   80 IYPLAN--TFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFfeYEVVECENCNNNSYY 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 200 EPRCEINDQ------KWYVISSCIGSFFAPCLIM----ILVYVRIYQIAKRRTRVPPSRR 249
Cdd:cd14978  158 YVIPTLLRQnetyllKYYFWLYAIFVVLLPFILLlilnILLIRALRKSKKRRRLLRRRRR 217
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
47-241 9.04e-19

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 86.16  E-value: 9.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMG-YWYFGKAWCEIYL 125
Cdd:cd14982    5 IVYSLIFILGLL------GNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGgWWPFGDFLCRLTG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppaePRCEI 205
Cdd:cd14982   78 LLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNS----TTCFE 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 206 NDQKW------YVISSCIGSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd14982  154 FLSEWlasaapIVLIALVVGFLIPLLIILVCYSLIIRALRRR 195
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
54-247 9.96e-19

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 85.94  E-value: 9.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15073    6 YLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQaIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqpPAEPRCEINDQK---- 209
Cdd:cd15073   86 ASIGLLTVVAVDRYLTICR-PDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALD----PTGATCTINWRKndss 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 210 --WYVISSCIGSFFAPCLIMILVYVRIYQIAKRRT--RVPPS 247
Cdd:cd15073  161 fvSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLasDCLES 202
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
50-452 1.21e-18

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 85.73  E-value: 1.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15970    8 SVVCLVGLC------GNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQK 209
Cdd:cd15970   81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEPSQR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 210 W---YVISSCIGSFFAPCLIMILVYVRIYQiakrrtrvppsrrgpdaatappggterrpnglspgrgaglagaeaeplpt 286
Cdd:cd15970  161 WlavFVVYTFLMGFLLPVIAICLCYILIIV-------------------------------------------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 287 qlngapgepapagpreadaldleessssehaerppgprrpergpraqgKARASQVKPGgslprrgpgptgagapaagpge 366
Cdd:cd15970  191 ------------------------------------------------KMRVVALKAG---------------------- 200
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 367 ergggakasrWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNH 446
Cdd:cd15970  201 ----------WQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLSVILGYANSCANPILYGFLSD 270

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15970  271 NFKRSF 276
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
49-252 1.40e-18

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 85.64  E-value: 1.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15399    1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKAIIVTV-WVISAVISFPPLI-----SIEKKGSSGGQPPAE-- 200
Cdd:cd15399   81 ALAVHVSTVTLTVIALDRHRCIVYHLE---SKISKKISFLIIGLtWAASALLASPLAIfreysVIEISPDFKIQACSEkw 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 201 PRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYqiAKRRTRVPPSRRGPD 252
Cdd:cd15399  158 PNGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIW--TKLKNHVSPGGGNDH 207
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
49-234 2.36e-18

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 84.50  E-value: 2.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKAIIVTVWVISAVISFPPLIsiekkGSSGGQ-PPAEPRCEIN- 206
Cdd:cd15404   81 WLFVMEGVAILLIISIDRFLIIVQKQD---KLNPYRAKVLIAVSWAVSFCVAFPLAV-----GSPDLQiPSRAPQCVFGy 152
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 207 ----DQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15404  153 ttnpGYQAYVILIMLIFFFIPFMVMLYSFMGI 184
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
61-242 2.37e-18

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 85.26  E-value: 2.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140
Cdd:cd15391   13 LSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 141 AISLDRYWSITQAIEYnlKRTPRRIKAIIVTVWVISAVIS----FPPLISIEKKGSSGGQPPAE--PrceiNDQKW---Y 211
Cdd:cd15391   93 AIGIDRFFAVIFPLRS--RHTKSRTKCIIASIWAISFSLSsvqlFAGRTQRYGQYSEGRVLCGEswP----GPDTSrsaY 166
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 212 VISSCIGSFFAPCLIMILVYVRI-YQIAKRRT 242
Cdd:cd15391  167 TVFVMLLTYIIPLLILTSTYGYVgFRLWNRTA 198
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
49-241 2.48e-18

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 84.83  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLmllTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFS--LANEVMGYWYFgkawCEIYLA 126
Cdd:cd15070    4 ISIEILIGLC---AVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAivVSLGVTIHFYS----CLFMSC 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEIN 206
Cdd:cd15070   77 LLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFT 156
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 826349104 207 D---QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd15070  157 SvmrMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNK 194
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
51-249 2.77e-18

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 84.85  E-value: 2.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15972    9 VVCVVGLG------GNTLVIYVVLRYSASESVTNIYILNLALADELF-MLGLPFLAAQNALSYWPFGSFMCRLVMTVDAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKW 210
Cdd:cd15972   82 NQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPEPAQVWRAG 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIY---QIAKRRTRVPPSRR 249
Cdd:cd15972  162 FIIYTATLGFFCPLLVICLCYLLIVvkvRSSGRRVRATSTKR 203
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
45-234 8.36e-18

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 83.28  E-value: 8.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANeVMGYWYFGKAWCEIY 124
Cdd:cd15175    3 LPAMYSVICFLGLL------GNGLVILTYIYFKRLKTMTDIYLLNLALADILFL-LTLPFWAAS-AAKKWVFGEEMCKAV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRtPRRI---KAIIVTVWVISAVISFPPLISIEKKGSSGgqppaEP 201
Cdd:cd15175   75 YCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRHR-SRAVfisKVSSLGVWVLAFILSIPELLYSGVNNNDG-----NG 148
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 202 RCEI--NDQKWY----VISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15175  149 TCSIftNNKQTLsvkiQISQMVLGFLVPLVVMSFCYSVI 187
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
47-240 1.50e-17

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 83.67  E-value: 1.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLMLLTVFGNVLVIIaVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIY-VLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSG 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqppAEPRCEIN 206
Cdd:PHA03087 117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHE----TLICCMFY 192
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 207 DQK------WYVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:PHA03087 193 NNKtmnwklFINFEINIIGMLIPLTILLYCYSKILITLKG 232
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
47-249 1.59e-17

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 82.54  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVglLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLAnEVMGY--WYFGKAWCEIY 124
Cdd:cd15928    1 AAVTAVCSV--LMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDLY-RLWRYrpWRFGDLLCRLM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCE 204
Cdd:cd15928   77 YFFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECT 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 205 IndqkwYVISSCIGS---------FFAPCLIMILVY---VRIYQIAKRRTRVPPSRR 249
Cdd:cd15928  157 V-----VNVSSGLLSvmlwvstsfFFVPMVCLSLLYgliGRALWDRRQRSRTAGASR 208
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
50-241 1.86e-17

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 82.05  E-value: 1.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15206    2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqpPAEPRC------ 203
Cdd:cd15206   82 VSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSR---PGGHKCrevwpn 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 826349104 204 EINDQKWYVISSCIgSFFAPCLIMILVYVRIYQ---IAKRR 241
Cdd:cd15206  159 EIAEQAWYVFLDLM-LLVIPGLVMSVAYGLISWtllEAKKR 198
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
44-231 1.87e-17

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 82.22  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  44 SLQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEI 123
Cdd:cd15092    2 TIVVVYLIVCVVGLV------GNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI--SIEKKGSSggqppAEP 201
Cdd:cd15092   75 VIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVmgSAQVEDEE-----IEC 149
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 826349104 202 RCEINDQKWY---VISSCIG--SFFAPCLIMILVY 231
Cdd:cd15092  150 LVEIPTPQDYwdpVFGICVFlfSFIIPVLIISVCY 184
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
49-249 1.89e-17

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 82.52  E-value: 1.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15094    1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVLT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQ------PPAEPr 202
Cdd:cd15094   80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYsctivwPDSSA- 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 826349104 203 ceINDQKWYVISSCIGSFFAPCLIMILVYVRIyqIAKRRTRVPPSRR 249
Cdd:cd15094  159 --VNGQKAFTLYTFLLGFAIPLLLISVFYTLV--ILRLRTVGPKNKS 201
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
57-184 2.23e-17

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 81.91  E-value: 2.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15214    8 IIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASM 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL 184
Cdd:cd15214   88 LTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPL 135
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
49-269 2.99e-17

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 81.97  E-value: 2.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQ-NLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
Cdd:cd15382    1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSRvNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DV--LFCTSSIvhLCAISLDRYWSITQAIeyNLKRTPRRIKAIIVTVWVISAVISFP----------PLISIEKKGSSGG 195
Cdd:cd15382   81 RAfgLYLSSFV--LVCISLDRYFAILKPL--RLSDARRRGRIMLAVAWVISFLCSIPqsfifhveshPCVTWFSQCVTFN 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 196 QPPAEprceiNDQKWYVISSCIGSFFAPCLIMILVYVRI-YQIAKRrtrvppSRRGPDAATAPPGGTERRPNGLS 269
Cdd:cd15382  157 FFPSH-----DHELAYNIFNMITMYALPLIIIVFCYSLIlCEISRK------SKEKKEDVSEKSSSVRLRRSSVG 220
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-231 3.03e-17

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 81.55  E-value: 3.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMGyWYFGKAWCEIYLALD 128
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFA-LTLPFWAVSVVKG-WIFGTFMCKLVSLLQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRR--IKAIIVTVWVISAVISFPPLISIE--KKGSSGGQPPAEPRCE 204
Cdd:cd15178   79 EANFYSGILLLACISVDRYLAIVHATR---ALTQKRhlVKFVCAGVWLLSLLLSLPALLNRDafKPPNSGRTVCYENLGN 155
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 205 INDQKWYV---ISSCIGSFFAPCLIMILVY 231
Cdd:cd15178  156 ESADKWRVvlrILRHTLGFLLPLVVMLFCY 185
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
56-243 3.80e-17

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 81.13  E-value: 3.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEI--YLALDVLFCT 133
Cdd:cd15196    8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLvkYLQVVGMYAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIvhLCAISLDRYWSITQAIEYnLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQ--------PPAEPRcei 205
Cdd:cd15196   88 SYV--LVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGVydcwatfePPWGLR--- 161
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 206 ndqkWYVISSCIGSFFAPCLIMILVYVRI-YQIAKRRTR 243
Cdd:cd15196  162 ----AYITWFTVAVFVVPLIILAFCYGRIcYVVWRAKIK 196
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
45-452 3.96e-17

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 81.44  E-value: 3.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15973    3 IQFIYALVCLVGLI------GNSMVIFVILRYAKMKTATNIYILNLAIADELF-MLSVPFLAASAALQHWPFGSAMCRTV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPaeprCE 204
Cdd:cd15973   76 LSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVA----CN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 205 I--NDQKW---YVISSCIGSFFAPCLIMILVYVRIYqiakrrtrvppsrrgpdaatappggterrpnglspgrgaglaga 279
Cdd:cd15973  152 LiwPHPAWsaaFVIYTFLLGFLLPVLAIGLCYILII-------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 280 eaeplptqlngapgepapagpreadaldleessssehaerppgprrpergpraqGKARASQVKPGgslprrgpgptgaga 359
Cdd:cd15973  188 ------------------------------------------------------GKMRAVALKAG--------------- 198
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 360 paagpgeergggakasrWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPV 439
Cdd:cd15973  199 -----------------WQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPRLDATVNHASLILSYANSCANPI 261
                        410
                 ....*....|...
gi 826349104 440 IYTIFNHDFRRAF 452
Cdd:cd15973  262 LYGFLSDNFRRSF 274
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
45-249 4.18e-17

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 81.39  E-value: 4.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15974    3 IPVIYLLVCAIGLS------GNTLVIYVVLRYAKMKTVTNIYILNLAVADELF-MLGLPFLATQNAISYWPFGSFLCRLV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI--SIEKKGSSGGQPPAEPR 202
Cdd:cd15974   76 MTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIfsDVQPDLNTCNISWPEPV 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 203 ceindQKW---YVISSCIGSFFAPCLIMILVYVRIY-QIAKRRTRVPPSRR 249
Cdd:cd15974  156 -----SVWstaFIIYTAVLGFFGPLLVICLCYLLIViKVKSSGLRVGSTKR 201
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
47-249 6.73e-17

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 80.42  E-value: 6.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVIIaVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAWCEIYL 125
Cdd:cd14974    5 VLYALIFLLGLP------GNGLVIW-VAGFKMKRTVNTVWFLNLALAD-FLFCLFLPFLIVYIAMGHhWPFGSVLCKLNS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI-----SIEKKGSSGGQPPAE 200
Cdd:cd14974   77 FVISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVfrdtvTHHNGRSCNLTCVED 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 201 PRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYqIAKRRTRVPPSRR 249
Cdd:cd14974  157 YDLRRSRHKALTVIRFLCGFLLPLLIIAICYSVIA-VKLRRKRLAKSSK 204
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
51-249 6.96e-17

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 80.66  E-value: 6.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15971    9 VVCIIGLC------GNTLVIYVILRYAKMKTVTNIYILNLAIADELF-MLGLPFLAIQVALVHWPFGKAICRVVMTVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkgsSGGQPPAEPRCEIN---- 206
Cdd:cd15971   82 NQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMI-------YAGVQTKHGRSSCTiiwp 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 207 --DQKWY---VISSCIGSFFAPCLIMILVYVRIyqIAKRRT---RVPPSRR 249
Cdd:cd15971  155 geSSAWYtgfIIYTFILGFFVPLTIICLCYLFI--IIKVKSsgiRVGSSKR 203
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
49-246 9.13e-17

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 80.52  E-value: 9.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15195    1 LVRVLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKAIIVTVWVISAVISFPPLIsIEKKGSSGGQPPAEPRC---EI 205
Cdd:cd15195   81 QFGMYLSSFMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPQSF-IFSVLRKMPEQPGFHQCvdfGS 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 206 NDQKW----YVISSCIGSFFAPCLIMILVYVRI-YQIAK--RRTRVPP 246
Cdd:cd15195  158 APTKKqerlYYFFTMILSFVIPLIITVTCYLLIlFEISKmaKRARDTP 205
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
48-234 1.40e-16

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 80.21  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  48 TLTLVCLVgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
Cdd:cd15205    1 TAFVITYV-LIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRC---- 203
Cdd:cd15205   80 QSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVCcler 159
                        170       180       190
                 ....*....|....*....|....*....|...
gi 826349104 204 --EINDQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15205  160 wySPTQQKIYTTFILVILFLLPLTTMLFLYSRI 192
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
53-234 2.78e-16

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 78.86  E-value: 2.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  53 CLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFC 132
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS--IEKKGSSGGQppaePRCE-----I 205
Cdd:cd15095   85 QATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYyrLEEGYWYGPQ----TYCRevwpsK 160
                        170       180
                 ....*....|....*....|....*....
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15095  161 AFQKAYMIYTVLLTYVIPLAIIAVCYGLI 189
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
57-256 4.16e-16

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 78.62  E-value: 4.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEI--YLALDVLFCTS 134
Cdd:cd15197    9 VLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVirYLQVVVTYAST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 135 SIvhLCAISLDRYWSITQAIeyNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqppaEPRCEIN---DQKWY 211
Cdd:cd15197   89 YV--LVALSIDRYDAICHPM--NFSQSGRQARVLICVAWILSALFSIPMLIIFEKTGLSNG----EVQCWILwpePWYWK 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 212 VISSCIGS--FFAPCLIMILVYVRIYQI--AKRRTRVPPSRRGPDAATA 256
Cdd:cd15197  161 VYMTIVAFlvFFIPATIISICYIIIVRTiwKKSKIQVTINKAGLHDGSS 209
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
50-249 4.20e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 78.41  E-value: 4.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15402    2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekkgssgGQPPAEPR---CEIN 206
Cdd:cd15402   82 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFV--------GSLQYDPRiysCTFA 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 207 D--QKWYVISSCIGSFFAPCLIMILVYVRIY-QIAKRRTRVPPSRR 249
Cdd:cd15402  154 QsvSSAYTIAVVFFHFILPIIIVTFCYLRIWiLVIQVRRRVKPDNK 199
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
54-185 4.30e-16

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 78.28  E-value: 4.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd14971    6 FFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMH 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd14971   86 ASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA 137
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
51-255 7.70e-16

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 77.93  E-value: 7.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLlmlltvFGNVLVIIaVFTSRALKAPQ---NLFLVSLASADILVAtLVIPFSLANEVMGY-WYFGKAWCEIYLA 126
Cdd:cd14976    9 VVFTVGL------LGNLLVLY-LLKSNKKLRQQsesNKFVFNLALTDLIFV-LTLPFWAVEYALDFvWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQP------PAE 200
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTlcllrfPKN 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 201 PRCEiNDQKW---YVISSCIGSFFAPCLIMILVYVRI-YQIAKRRTRvppSRRGPDAAT 255
Cdd:cd14976  161 SSVT-RWYNWlgmYQLQKVVLGFFLPLGIITLSYLLLlRFLQRKRGG---SKRRKSRVT 215
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
45-251 1.11e-15

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 77.11  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFsLANEVM--GYWYFGKAWCE 122
Cdd:cd15088    3 MPSVFGCICVVGLV------GNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPF-LIHQFAidGQWYFGEVMCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI-SIEKKGSSGGQPPAEP 201
Cdd:cd15088   75 IITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVySSLIYFPDGTTFCYVS 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 202 RCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvpPSRRGP 251
Cdd:cd15088  155 LPSPDDLYWFTIYHFILGFAVPLVVITVCYILILHRLARGVA--PGNQSH 202
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
48-244 1.75e-15

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 76.31  E-value: 1.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  48 TLTLVCLvGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
Cdd:cd15086    1 TVVAVFL-GFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTvWVISAVISFPPLISIEKKGSSGgqppAEPRCEINd 207
Cdd:cd15086   80 NSLFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGS-WLYSLLWTLPPLLGWSSYGPEG----PGTTCSVQ- 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 208 qkW---------YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15086  154 --WtsrsansisYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKI 197
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
45-248 2.03e-15

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 76.32  E-value: 2.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGyWYFGKAWCEIY 124
Cdd:cd15176    3 LPVFYTIALVVGLA------GNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKIT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIkaIIVTVWVISAVISFPPLI--SIEKKGSSGGQPPAEPR 202
Cdd:cd15176   75 SALYTMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCWI--VCLCVWLLAILLSIPDLVfsTVRENSDRYRCLPVFPP 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 826349104 203 CEINDQKWYV-ISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSR 248
Cdd:cd15176  153 SLVTSAKATIqILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSR 199
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
54-234 2.33e-15

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 76.29  E-value: 2.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15393    6 LYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLIS------IEKKGSSggqppAEPRCE- 204
Cdd:cd15393   86 VSVFTLTVIAVDRY----RAVIHPLKArcSKKSAKIIILIIWILALLVALPVALAlrveelTDKTNNG-----VKPFCLp 156
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 205 --INDQKW--YVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15393  157 vgPSDDWWkiYNLYLVCVQYFVPLVIICYAYTRI 190
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
57-241 2.35e-15

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 76.42  E-value: 2.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFgkaWCEIYLALDVLFCT-SS 135
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF---YSCLMVACPVLILTqSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI------SIEKK---GSSGGQPPAEPRCE-I 205
Cdd:cd15071   86 ILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFgwnnlnAVERAwaaNSSMGELVIKCQFEtV 165
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd15071  166 ISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQ 201
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
50-249 2.78e-15

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 75.88  E-value: 2.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASAD-ILVATLviPFSLANEVMGY-WYFGKAWCEIYLAL 127
Cdd:cd14985    8 IAIFLVGLL------GNLFVVWVFLFPRGPKRVADIFIANLAAADlVFVLTL--PLWATYTANQYdWPFGAFLCKVSSYV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPA---EPRCE 204
Cdd:cd14985   80 ISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTAcimLYPHE 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 205 INDQKWYVISSCIGsFFAPCLIMILVYVRIYQ-IAKRRTRVPPSRR 249
Cdd:cd14985  160 AWHFGLSLELNILG-FVLPLLIILTCYFHIARsLRKRYERTGKNGR 204
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
43-233 4.38e-15

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 74.99  E-value: 4.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGllmlltVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCE 122
Cdd:cd15210    1 YFAAVWGIVFMVVG------VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIekkGSSGGQPPAEPR 202
Cdd:cd15210   75 VFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGI---WGRFGLDPKVCS 151
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 203 CEINDQKW---YVISSCIGSFFAPCLIMILVYVR 233
Cdd:cd15210  152 CSILRDKKgrsPKTFLFVFGFVLPCLVIIICYAR 185
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
54-240 5.20e-15

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 74.88  E-value: 5.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15215    5 LIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIsiekkgsSGGQPPAEPRCEINDQKW--- 210
Cdd:cd15215   85 AGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLY-------GWGQAAFDERNALCSVIWgss 157
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 211 --YVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:cd15215  158 ysYTILSVVSSFVLPVIIMLACYSMVFRAARR 189
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
52-231 6.39e-15

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 74.91  E-value: 6.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15978    4 ILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP-PLIS-----IEKKGSSGGQPPAEPRCEI 205
Cdd:cd15978   84 VSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPyPIYSnlvpfTRINNSTGNMCRLLWPNDV 163
                        170       180
                 ....*....|....*....|....*.
gi 826349104 206 NDQKWYVISSCIgSFFAPCLIMILVY 231
Cdd:cd15978  164 TQQSWYIFLLLI-LFLIPGIVMMTAY 188
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
52-290 8.38e-15

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 75.19  E-value: 8.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVL 130
Cdd:cd15005    4 LTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIekkGSSGGQpPAEPRCeINDQKW 210
Cdd:cd15005   84 FCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDV---GTYTFI-REEDQC-TFEHRS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMI---LVYVRIYQIAKRRTRVPPSRRGPDAAT----APPGGTERRPNGLSPGRGAGlagaeaeP 283
Cdd:cd15005  159 YKANDTLGFMLVLAVVIAathLVYLKLLIFLRHHRKMKPAQLVPAISQnwtfHGPGATGQAAANWTAGFGRG-------P 231

                 ....*..
gi 826349104 284 LPTQLNG 290
Cdd:cd15005  232 TPPTLLG 238
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
56-245 1.07e-14

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 74.40  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGyWYFGKAWCEIYLALDVL--FCT 133
Cdd:cd15181    8 SLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLnfYCS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIvhLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEkkgSSGGQPPAEPRCE-----INDQ 208
Cdd:cd15181   86 SLL--LACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLE---VETSTNANRTSCSfhqygIHES 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 209 KWYVISSC---IGSFFAPCLIMILVYVRIYQIAKRRTRVP 245
Cdd:cd15181  161 NWWLTSRFlyhVVGFFLPLLIMGYCYATIVVTLCQSSRRL 200
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
50-182 1.19e-14

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 73.96  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVatlVIPFSLANEVMGY-----WYFGKAWCEIY 124
Cdd:cd14995    2 VATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMV---LVAAGLPNEIESLlgpdsWIYGYAGCLLI 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd14995   79 TYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSP 136
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
50-231 1.46e-14

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 73.83  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15091    8 SVVFVVGLV------GNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekKGSSGGQPPAEPRCEI---N 206
Cdd:cd15091   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVL---GGTKVREDVDSTECSLqfpD 157
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 207 DQKWY---VISSC--IGSFFAPCLIMILVY 231
Cdd:cd15091  158 DDYSWwdtFMKICvfIFAFVIPVLIIIVCY 187
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
51-249 1.53e-14

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 73.66  E-value: 1.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15209    3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekkgssgGQPPAEPR---CEIND 207
Cdd:cd15209   83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFI--------GSLQYDPRiysCTFAQ 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 208 --QKWYVISSCIGSFFAPCLIMILVYVRIY-QIAKRRTRVPPSRR 249
Cdd:cd15209  155 tvSTVYTITVVVIHFLLPLLIVSFCYLRIWvLVLQVRQRVKPDQR 199
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
52-244 1.55e-14

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 73.94  E-value: 1.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALK-APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15383    4 VAVTFVLFVLSACSNLAVLWSATRNRRRKlSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqPPAEPRCEIN---D 207
Cdd:cd15383   84 AMYSSAFVTVVISLDRHAAILNPLAIGSAR--RRNRIMLCAAWGLSALLALPQLFLFHTVTATP--PVNFTQCATHgsfP 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 208 QKW----YVISSCIGSFFAPCLIMILVYVRI-YQIAKRRTRV 244
Cdd:cd15383  160 AHWqetlYNMFTFFCLFLLPLLIMIFCYTRIlLEISRRMKEK 201
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
50-186 2.36e-14

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 73.23  E-value: 2.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd14977    2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS 186
Cdd:cd14977   82 TSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVL 138
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
54-247 2.59e-14

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 72.92  E-value: 2.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPqNLFLVSLASADiLVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVL-- 130
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTIIRSRKKTVP-DIYVCNLAVAD-LVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCnq 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVhlCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI-SIEKKGSSGGQPPAEPRCEINDQK 209
Cdd:cd15339   84 FACSAIM--TAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVyAKVIKFRDGLESCAFNLTSPDDVL 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 210 WYVISSCIGSFFAP------CLIMILVYV-RIYQIAKRRTRVPPS 247
Cdd:cd15339  162 WYTLYQTITTFFFPlpliliCYILILCYTwEMYRKNKKAGRYNTS 206
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
58-182 2.96e-14

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 72.97  E-value: 2.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15357   10 IFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYpFLFGPVGCYFKTALFETVCFASI 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15357   90 LSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIP 135
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
51-234 3.18e-14

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 72.86  E-value: 3.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVMGyWYFGKAWCEIYLALDV 129
Cdd:cd15174    9 LIFLVGAV------GNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLfLCTL--PFWATAASSG-WVFGTFLCKVVNSMYK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPR--RIKAIIVTVWVISAVISFPPLI--SIEKKGSSGGQPPAEPRCEI 205
Cdd:cd15174   80 INFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVWLLSTILSLPEILfsQSKEEESVTTCTMVYPSNES 159
                        170       180       190
                 ....*....|....*....|....*....|.
gi 826349104 206 NDQKWYVIS--SCIGsFFAPCLIMILVYVRI 234
Cdd:cd15174  160 NRFKVAVLAlkVTVG-FFLPFVVMVICYTLI 189
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-279 4.45e-14

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 72.14  E-value: 4.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVA------TLVIpfSLANevMGYWYFGKAWCE-IYLALDVL 130
Cdd:cd15103   10 LGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnaleTIVI--ILLN--NGYLVPRDSFEQhIDNVIDSM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgssggqppaeprceind 207
Cdd:cd15103   86 ICSSllaSICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDSV----------------- 148
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 208 qkwYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsrrgpdaatappgGTERRPNGLSPGRGAGLAGA 279
Cdd:cd15103  149 ---PVIICLISMFFAMLVLMASLYVHMFLLARSHVK----------------KIAALPGQRSTRQRANMKGA 201
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
47-234 8.23e-14

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 71.71  E-value: 8.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEvMGYWYFGKAWCEIYL 125
Cdd:cd15172    5 VIYSLICVVGLI------GNSLVVITYAFYKRTKSMTDVYLLNMAIADILfVLTL--PFWAVYE-AHQWIFGNFSCKLLR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIE-YNLK-RTPRRIKAIIVTVWVISAVISFPPLISIEK-KGSSGGQPPAEPR 202
Cdd:cd15172   76 GIYAINFYSGMLLLACISVDRYIAIVQATKsFRLRsRTLAYSKLICAAVWLLAILISLPTFIFSEVyDFGLEEQYVCEPK 155
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 826349104 203 CEINDQ----KWYVISSCIG-SFFAPCLIMILVYVRI 234
Cdd:cd15172  156 YPKNSTaimwKLLVLSLQVSlGFFIPLLVMIFCYSFI 192
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-272 9.08e-14

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 71.79  E-value: 9.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLT-VFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDV 129
Cdd:cd15133    3 VCLTYLLIFVVgVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYpFLLGSGGCYFKTFLFE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPlISIEKKGSSGGQPPAEPRCEINDQK 209
Cdd:cd15133   83 TVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPN-TSLHGIKFLGSGVPASAQCTVRKPQ 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 210 W-YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRvppsRRGPDAATApPGGTERRPNGLSPGR 272
Cdd:cd15133  162 AiYNMIPQHTGHLFFVLPMAVISVLYLLMALRLAR----ERGLDATGA-GSKIGTRTGQLLQHP 220
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
43-234 9.22e-14

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 71.34  E-value: 9.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFsLANEVMGYWYFGKAWC 121
Cdd:cd15173    1 YFLPCMYSVMFVTGLV------GNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLfLCTL--PF-WAYSAAHEWIFGTVMC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 122 EIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRI--KAIIVTVWVISAVISFPPLI-----SIEKKGSSG 194
Cdd:cd15173   72 KITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRwgKVVCTLVWVISLLLSLPQFIysevrNLSSKICSM 151
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 195 GQPPAEPRCEINdqkwyVISSCIGsFFAPCLIMILVYVRI 234
Cdd:cd15173  152 VYPPDAIEVVVN-----IIQMTVG-FFLPLLAMIICYSVI 185
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
61-243 9.98e-14

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 71.50  E-value: 9.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  61 LTVFGNVLVIIAVFTSRALKAPQNLFLVS-LASADILVAT--LVIPFSLANEVMGYWYFGKAW-----CEIYLALDVLFC 132
Cdd:cd14980   13 LALIGNILVIIWHISSKKKKKKVPKLLIInLAIADFLMGIylLIIAIADQYYRGRYAQYSEEWlrsppCLLACFLVSLSS 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNlKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRC-----EIND 207
Cdd:cd14980   93 LMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYGYSSICmpsnvSNPY 171
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 208 QKWYVISSCIGSFFApCLIMILVYVRIYqIAKRRTR 243
Cdd:cd14980  172 YRGWLIAYLLLTFIA-WIIICILYILIF-ISVRKSR 205
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
53-234 1.17e-13

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 70.96  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  53 CLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMGyWYFGKAWCEIYLALDVLFC 132
Cdd:cd15177    5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLL-LTLPFAAAETLQG-WIFGNAMCKLIQGLYAINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLISiekkgSSGGQPPAEPRC-----EI 205
Cdd:cd15177   83 YSGFLFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIY-----SRVENRSELSSCrmifpEV 157
                        170       180       190
                 ....*....|....*....|....*....|...
gi 826349104 206 NDQK----WYVISSCIGsFFAPCLIMILVYVRI 234
Cdd:cd15177  158 VSRTvkgaTALTQVVLG-FAIPLIVMAVCYAAI 189
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-182 1.29e-13

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 71.11  E-value: 1.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd16003    8 GFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFAS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPrrIKAIIVTVWVISAVISFP 182
Cdd:cd16003   88 IYSMTAIAVDRYMAIIDPLKPRLSATA--TKVVIGSIWILAFLLAFP 132
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
51-243 1.38e-13

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 70.71  E-value: 1.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15401    3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekkgssgGQPPAEPR---CEIND 207
Cdd:cd15401   83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFV--------GSLQYDPRiysCTFAQ 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 826349104 208 --QKWYVISSCIGSFFAPCLIMILVYVRIYQI---AKRRTR 243
Cdd:cd15401  155 tvSSSYTITVVVVHFIVPLSIVTFCYLRIWVLviqVKHRVR 195
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
49-237 2.32e-13

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 69.79  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVgLLMLLTVFGNVLVIIAVFTSRALKapQNLFLVSLASADILVATLVIPFSL--ANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15220    1 VGLFCMV-LLDLTALVGNTAVMVVIAKTPHLR--KFAFVCHLCVVDLLAALLLMPLGIlsSSPFFLGVVFGEAECRVYIF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGssGGQPPAEPRCEI- 205
Cdd:cd15220   78 LSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYG--GPAPIAARHCSLh 155
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 206 ----NDQKWYVISSCIGSFFAPCLIMILVYVRIYQI 237
Cdd:cd15220  156 wshsGHRGVFVVLFALVCFLLPLLLILVVYCGVFKV 191
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
54-187 3.72e-13

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 70.36  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFC 132
Cdd:cd15217    6 LLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSaWTYSVLSCKIVAFMAVLFC 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15217   86 FHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDV 140
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
49-250 4.92e-13

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 69.38  E-value: 4.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15397    1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRIKAIIVTVWVISAVISFPPLI------SIEKKGSSGGQPPAEPr 202
Cdd:cd15397   81 CMSVTVSILSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWMLACFISLPFLAfhiltdEPYKNLSHFFAPLADK- 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 203 cEINDQKW--------YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG 250
Cdd:cd15397  158 -AVCTESWpsehhklaYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGE 212
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
54-234 5.07e-13

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 69.33  E-value: 5.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVMGyWYFGKAWCEIYLALDVLFC 132
Cdd:cd15180    6 LYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILlLVTL--PFWAVQAVHG-WIFGTGLCKLAGAVFKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIE-KKGSSGGQPPAEPRCEINDQKWY 211
Cdd:cd15180   83 YCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEaTKDPRQNKTECVHNFPQSDTYWW 162
                        170       180
                 ....*....|....*....|....*.
gi 826349104 212 VISSC---IGSFFAPCLIMILVYVRI 234
Cdd:cd15180  163 LALRLlyhIVGFLLPLAVMVYCYTSI 188
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
49-243 5.43e-13

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 69.39  E-value: 5.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15384    1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWsitqAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLISIekKGSSGGQPPAEPRCEIN 206
Cdd:cd15384   81 VFGLYLSTYITVLISLDRCV----AILYPMKRnqAPERVRRMVTVAWILSPIFSIPQAVIF--HVERGPFVEDFHQCVTY 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 826349104 207 ---DQKW----YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15384  155 gfyTAEWqeqlYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSR 198
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
45-182 6.16e-13

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 69.00  E-value: 6.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15087    3 LPVIYSVICAVGLT------GNTAVIYVILRAPKMKTVTNVFILNLAIADDLF-TLVLPINIAEHLLQQWPFGELLCKLI 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRI----KAIIVTVWVISAVISFP 182
Cdd:cd15087   76 LSIDHYNIFSSIYFLTVMSVDRYLVVLATVRS--RRMPYRTyraaKIVSLCVWLLVTIIVLP 135
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
43-247 9.34e-13

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 68.50  E-value: 9.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMG-YWYFGKAWC 121
Cdd:cd15168    1 IFLPIVYGVVFLVGLL------LNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYL-LSLPFLIYYYANGdHWIFGDFMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 122 EI--YLALDVLFCtsSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQ--- 196
Cdd:cd15168   74 KLvrFLFYFNLYG--SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTtcy 151
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 826349104 197 ---PPAEPrceiNDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPS 247
Cdd:cd15168  152 dttSPEEL----NDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVT 201
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
54-234 9.46e-13

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 68.32  E-value: 9.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15008    5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKAIIVTVWVISAVISFPPLISIekkgssGGQPpaEPRCEIN-DQKW-- 210
Cdd:cd15008   85 VQIYVLLSICVDRFYTIVYPLSFKVSR--EKAKKMIAASWLFDAAFVSPALFFY------GSNW--GPHCNFFlPDSWdg 154
                        170       180
                 ....*....|....*....|....*.
gi 826349104 211 --YVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15008  155 aaYAIIHLLVGFLVPSILIILFYQKV 180
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
56-185 1.04e-12

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 68.23  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTS 134
Cdd:cd15192    8 SIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALAD-LCFLITLPLWAAYTAMEYhWPFGNFLCKIASALVSFNLYA 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 135 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15192   87 SVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAII 137
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
54-236 1.25e-12

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 67.91  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQN---LFLVSLASADILVaTLVIPFsLANEVMG--YWYFGKAWCEIYLALD 128
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRCQQTvpdIFIFNLSIVDLLF-LLGMPF-LIHQLLGngVWHFGETMCTLITALD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISavisfppLISIEKKGSSGGQPPAEP---RCEI 205
Cdd:cd15338   84 TNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILS-------LLSITPVWMYAGLMPLPDgsvGCAL 156
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 826349104 206 ------NDQKWYVISSCIGSFFAPCLIMILVYVRIYQ 236
Cdd:cd15338  157 llpnpeTDTYWFTLYQFFLAFALPLVVICVVYFKILQ 193
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
49-243 1.66e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 67.99  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLAnEVMGY--WYFGKAWCEIYLA 126
Cdd:cd15131    3 ITVTCV--LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLY-RLWQYrpWNFGDLLCKLFQF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEIN 206
Cdd:cd15131   79 VSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKAT 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 207 DqkwYVISSCIGS---------FFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15131  159 E---YAVRSGLLTimvwvssvfFFLPVFCLTVLYSLIGRKLWRRRR 201
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
57-244 1.98e-12

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 67.39  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGyWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15182    9 LVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISD-LLFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqpPAEPRCEINDQKWYVISSC 216
Cdd:cd15182   87 LFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSD----EDGSLCEYSSIKWKLGYYY 162
                        170       180       190
                 ....*....|....*....|....*....|.
gi 826349104 217 IGS--FFAPCLIMILVYVRIYQ-IAKRRTRV 244
Cdd:cd15182  163 QQNlfFLIPLGIIVYCYVRILQtLMRTRTMR 193
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
56-244 2.02e-12

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 67.74  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFslanEVMGYWY-----FGKAWCeIYLALDVL 130
Cdd:cd15134    8 GIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPF----ELYTIWQqypwvFGEVFC-KLRAFLSE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTS-SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP-PLIS----IEKKGSSGGQPPAEPRCE 204
Cdd:cd15134   83 MSSYaSVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPfAIQTrivyLEYPPTSGEALEESAFCA 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 205 INDQK-----WYVISSCIgSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15134  163 MLNEIppitpVFQLSTFL-FFIIPMIAIIVLYVLIGLQLRRSTLL 206
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
51-185 2.18e-12

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 67.46  E-value: 2.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLAN--EVMGyWYFGKAWCEIYLALD 128
Cdd:cd15394    3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYafEPRG-WVFGRFMCYFVFLMQ 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 129 VLFCTSSIVHLCAISLDRYWsitqAIEYNLKR--TPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15394   82 PVTVYVSVFTLTAIAVDRYY----VTVYPLRRriSRRTCAYIVAAIWLLSCGLALPAAA 136
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
43-185 2.49e-12

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 67.29  E-value: 2.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCE 122
Cdd:cd15927    1 YVVPILFALIFLVGVL------GNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCK 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 123 IylaLDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15927   75 L---SEFLKDTSigvSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAI 137
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-241 3.34e-12

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 66.92  E-value: 3.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM--GYWYFGKAWCEI--YLALDVLFC 132
Cdd:cd15204    9 LIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVrqRSWTHGDVLCAVvnYLRTVSLYV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 tsSIVHLCAISLDRYWSITQAieYNLKRTPRRIKAIIVTVWVISAVISFPP-----LISIEKKGSS-GGQP-PAEPRcei 205
Cdd:cd15204   89 --STNALLVIAIDRYLVIVHP--LKPRMKRRTACVVIALVWVVSLLLAIPSavyskTTPYANQGKIfCGQIwPVDQQ--- 161
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRI-YQIAKRR 241
Cdd:cd15204  162 AYYKAYYLFLFVLEFVLPVLIMTLCYLRIvRKVWFRR 198
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
47-243 4.83e-12

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 66.28  E-value: 4.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVIIaVFTSRALKAPQNL---FLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEI 123
Cdd:cd15002    4 ILLGVICLLGFA------GNLMVIG-ILLNNARKGKPSLidsLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQ-AIEYNLKrtPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGG------- 195
Cdd:cd15002   77 ADWFGHACMAAKSFTIAVLAKACYMYVVNpTKQVTIK--QRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVylcilci 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 196 QPPAEPrceinDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15002  155 PPLAHE-----FMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGT 197
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-234 4.85e-12

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 66.72  E-value: 4.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLT-VFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDV 129
Cdd:cd15358    3 VCVTYLLIFVVgAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYpFLLGAGGCYFKTLLFE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP--PLISIEK-KGSSGGQPPAEPRCEIN 206
Cdd:cd15358   83 TVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPntSLHGIFQlTVPCRGPVPDSATCMLV 162
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 207 DQKWY----VISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15358  163 KPRWMynliIQITTLLFFFLPMGTISVLYLLI 194
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-183 5.75e-12

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 66.36  E-value: 5.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLAnEVMGY--WYFGKAWCEIY 124
Cdd:cd15132    1 IPVTIVCL--ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDLY-RLWKSrpWIFGEFLCRLY 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVIsAVISFPP 183
Cdd:cd15132   77 HYISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAF-ALLSAGP 134
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
45-249 6.70e-12

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 66.07  E-value: 6.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRAL-KAPQNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAWCE 122
Cdd:cd15926    3 ISIVYSVVCALGLV------GNLLVLYLMKSKQGWkKSSINLFVTSLAVTD-FQFVLTLPFWAVENALDFtWLFGKAMCK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekkgSSGGQPPAEPR 202
Cdd:cd15926   76 IVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIF-----STTATVSNEEL 150
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 203 CEI-------NDQKW---YVISSCIGSFFAPCLIMILVYVRIYQ-IAKRRTRVPPSRR 249
Cdd:cd15926  151 CLVkfpdnrgNAQFWlglYHAQKVLLGFLIPLGIISLCYLLLVRfITDKNITGSSTKR 208
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
47-249 9.57e-12

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 65.55  E-value: 9.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVIIaVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGY-WYFGKAWCEIYL 125
Cdd:cd15116    5 VIYSVVFVLGVL------GNGLVIF-ITGFKMKKTVNTVWFLNLAVADFLF-TFFLPFSIAYTAMDFhWPFGRFMCKLNS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI-------SIEKKG------- 191
Cdd:cd15116   77 FLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIfrdtapsQNNNKIicfnnfs 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 192 -SSGGQPPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYqIAKRRTRVPPSRR 249
Cdd:cd15116  157 lSGDNSSPEVNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIV-LKLKRNRLAKSSK 214
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
45-253 9.68e-12

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 65.55  E-value: 9.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMG-YWYFGKAWCEI 123
Cdd:cd14991    3 LPPLLILEFVLGLP------GNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLI-CLPFRIDYYLRGeHWIFGEAWCRV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqppaePRC 203
Cdd:cd14991   76 NLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNK-----SSC 150
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 204 E--INDQK------WYVISSCIgSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDA 253
Cdd:cd14991  151 HsfSSYTKpslsirWHNALFLL-EFFLPLGLIVFCSVRIACNLRIRQSLGKQARVQRA 207
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
45-186 9.77e-12

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 65.62  E-value: 9.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLlmlltvFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15396    3 LIIAYSVVTIVGL------FGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLT 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQaieynlkrtPRRIKAI-------IVTVWVISAVISFPPLIS 186
Cdd:cd15396   77 SFVQSVSVSVSIFSLVLIAIERYQLIVN---------PRGWKPSashaywgIVLIWLFSLMISIPFLIF 136
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
50-240 1.17e-11

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 65.07  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGY-WYFGKAWCEIYLALD 128
Cdd:cd15159    8 SLILVFGLL------GNTLALHVICQKRKKINSTTLYLINLAVSDILF-TLALPGRIAYYALGFdWPFGDWLCRLTALLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL-ISIEKKgssggqPPAEPRC---- 203
Cdd:cd15159   81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLfMPMTKE------MGGRITCmeyp 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 826349104 204 ---EINDQKWYVISSCIGSFFAPCLIMILVYVRI----YQIAKR 240
Cdd:cd15159  155 nfeKIKRLPLILLGACVIGFGVPVGIILFCYSQItlklCRTAKE 198
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
63-247 1.21e-11

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 65.26  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  63 VFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAI 142
Cdd:cd15400   15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 143 SLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekkgssgGQPPAEPR---CEIND--QKWYVISSCI 217
Cdd:cd15400   95 AINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFV--------GSLEYDPRiysCTFVQtaSSSYTIAVVV 166
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 218 GSFFAPCLIMILVYVRIY----QIAKR-----RTRVPPS 247
Cdd:cd15400  167 IHFIVPITVVSFCYLRIWvlviQVRRKvksesKPRLKPS 205
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
56-234 1.46e-11

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 64.75  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKA--PQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIylaLDVLFCT 133
Cdd:cd15098    8 GLIFCLGVLGNSLVITVLARVKPGKRrsTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKF---VHYFFTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 S---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPplISIEKKGSSGGQPPAEPRC-----EI 205
Cdd:cd15098   85 SmlvSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASP--VAVHQDLVHHWTASNQTFCwenwpEK 162
                        170       180
                 ....*....|....*....|....*....
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15098  163 QQKPVYVVCTFVFGYLLPLLLITFCYAKV 191
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
57-182 1.53e-11

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 64.86  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd16004    9 LIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSI 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTprRIKAIIVTVWVISAVISFP 182
Cdd:cd16004   89 YSMTAIAADRYMAIIHPFKPRLSAG--STKVVIAGIWLVALALAFP 132
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
49-240 2.01e-11

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 64.44  E-value: 2.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFsLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15187    1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASD-LLFVFSLPF-QAYYLLDQWVFGNAMCKIVSGAY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIeYNLK-RTPRRIKAIIVTVWVIsAVISFPPLISIEKKGSSGGQPPAEPRCEIND 207
Cdd:cd15187   79 YIGFYSSMFFITLMSIDRYLAIVHAV-YALKvRTASHGTILSLALWLV-AILASVPLLVFYQVASEDGRLQCIPFYPGQG 156
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 208 QKWYVISSC---IGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:cd15187  157 NSWKVFTNFevnILGLLIPFSILIFCYHNILRNLRR 192
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
51-249 3.80e-11

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 63.74  E-value: 3.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIIAVFTSRALKA-PQNLFLVSLASADILVAtLVIPFSLANEVMGY-WYFGKAWCEIYLALD 128
Cdd:cd15925    9 LVCAIGLL------GNLAVMYLLRNCARRAPpPIDVFVFNLALADFGFA-LTLPFWAVESALDFhWPFGGAMCKMVLTAT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekkgSSGGQPPAEPRCEIN-- 206
Cdd:cd15925   82 VLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIF-----ATEGEVCGVELCLLKfp 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 207 DQKW---YVISSCIGSFFAPCLIMILVYVRIYQIAKRRtRVPPSRR 249
Cdd:cd15925  157 SNYWlgaYHLQRVVVAFVVPLGVITTSYLLLLSFLQQH-KVNQNNR 201
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
57-182 4.28e-11

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 63.75  E-value: 4.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15980    9 LIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASV 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 137 VHLCAISLDRYwsitQAIEYNLKR--TPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15980   89 FTLVAIAVDRF----RCIVYPFKQklTISTAVVIIVIIWVLAIAIMCP 132
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
54-185 5.46e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 63.03  E-value: 5.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRA--LKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWY-FGKAWCEIYLALDVL 130
Cdd:cd14981    6 PPALMFVFGVLGNLLALIVLARSSKshKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWdGGQPLCDYFGFMMSF 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd14981   86 FGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-182 5.55e-11

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 63.43  E-value: 5.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15125    9 LIITVGLL------GNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLT 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15125   83 SVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVP 134
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
58-247 6.55e-11

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 62.98  E-value: 6.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT--LVIPFSLANEVMGYWYFGKAWCE-IYLALDVLFCTS 134
Cdd:cd15352   10 LGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVsnSLETIMIAVLNSGYLVISDQFIQhMDNVFDSMICIS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 135 ---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgssggqppaeprceindqkwY 211
Cdd:cd15352   90 lvaSICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESK--------------------T 149
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 212 VISSCIGSFFAPCLIMILVYVRIYQIA----KRRTRVPPS 247
Cdd:cd15352  150 VIVCLITMFFAMLVLMATLYVHMFLFArlhvKRIAALPPA 189
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
57-185 6.60e-11

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 62.85  E-value: 6.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPF-SLANEVMGYWYFGKAWCEIY-LALDVLFCtS 134
Cdd:cd15193    9 IIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVAD-LVFVLTLPFwAASTALGGQWLFGEGLCKLSsFIIAVNRC-S 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 135 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15193   87 SILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLV 137
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
51-180 7.25e-11

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 62.66  E-value: 7.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15232    3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS 180
Cdd:cd15232   83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNS 132
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
52-182 9.45e-11

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 62.48  E-value: 9.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVL 130
Cdd:cd15212    4 ALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRpGWLFGDRLCLANGFFNAC 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKAIIVTVWVISAVISFP 182
Cdd:cd15212   84 FGIVSTLTMTLISFDRYYAIVRQPQGKIGR--RRALQLLAAAWLTALGFSLP 133
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
45-249 1.88e-10

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 61.34  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLV-IIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFsLANEVMGYWYFGKAWCEI 123
Cdd:cd15188    3 LPVFYTLVFLLGLA------GNLLLfVVLLLYVPKKKKMTEVYLLNLAVSDLLF-LVTLPF-WAMYVAWHWVFGSFLCKF 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRC 203
Cdd:cd15188   75 VSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADY 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 204 EINDQKWYVISSCIGS---FFAPCLIMILVYVRIYQIAKrRTRVPPSRR 249
Cdd:cd15188  155 GGHHTIWKLVFQFQQNllgFLFPLLAMVFFYSRIACVLT-RLRPPGQGR 202
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
55-307 1.99e-10

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 61.97  E-value: 1.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  55 VGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15218    7 LGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGsTWTYGTLTCKVIAFLGVLSCF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIekkgSSGGQPPAEPRCEINDQKWYVI 213
Cdd:cd15218   87 HTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDV----GTYSFIREEDQCTFQHRSFRAN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 214 SScIGSFFAPCLIMI---LVYVRIYQIAKRRTRVPPSRRgpdAATAPPGGTERRPNGLSPGRGAGLAGAEAEPLPTQLNG 290
Cdd:cd15218  163 DS-LGFMLLLALILLatqLVYLKLIFFVHDRRKMKPVQF---VAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLG 238
                        250
                 ....*....|....*..
gi 826349104 291 APGEPAPAGPREADALD 307
Cdd:cd15218  239 IRQNANTTGRRRLLVLD 255
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
50-268 2.14e-10

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 61.75  E-value: 2.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALD 128
Cdd:cd15198    2 TRLIFLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGdRWMAGDVACRLLKLLQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYwsitQAIEYNLKRtPRRIKAIIVTVWVISAVISFPPL--ISIEKKGSSGGQPPAEPRCE-- 204
Cdd:cd15198   82 ASARGASANLVVLLALDRH----QAIRAPLGQ-PLRAWKLAALGWLLALLLALPQAyvFRVDFPDDPASAWPGHTLCRgi 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 205 INDQ-KW----YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAATAPPGGTERRPNGL 268
Cdd:cd15198  157 FAPLpRWhlqvYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKSHLRATAPSAL 225
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
96-248 2.22e-10

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 61.34  E-value: 2.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  96 LVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWV 174
Cdd:cd15120   46 LIFTLILPFMAVHVLMDNhWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWI 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 175 ISAVISFPPLISIEKKGSSGGQppaePRCEIN-----------DQKWYV-------ISSCIGSFFAPCLIMILVYVRIYQ 236
Cdd:cd15120  126 SAILLSIPYLAFRETRLDEKGK----TICQNNyalstnwesaeVQASRQwihvamfVFRFLLGFLLPFLIITFCYVRMAL 201
                        170
                 ....*....|..
gi 826349104 237 IAKRRTRVPPSR 248
Cdd:cd15120  202 KMKERGLARSSK 213
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
58-243 2.32e-10

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 61.11  E-value: 2.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVA------TLVIpFSLANE--VMGYWYFGkawcEIYLALDV 129
Cdd:cd15354   10 LGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnaweTITI-YLLNNRhlVIEDAFVR----HIDNVFDS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLC---AISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgssggqppaeprcein 206
Cdd:cd15354   85 LICISVVASMCsllAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSEST---------------- 148
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 826349104 207 dqkwYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15354  149 ----YVIICLITMFFAMLFLMVSLYIHMFLLARTHVK 181
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
54-243 2.33e-10

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 61.31  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPF---SLANEvmgyWYFGKAWCEIYLALDVL 130
Cdd:cd15184    6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLF-LLTLPFwahYAANE----WVFGNAMCKLLTGLYHI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIeYNLKrtPRRIKAIIVT---VWVISAVISFPPLI--SIEKKGSSGGQPPAEPRCEI 205
Cdd:cd15184   81 GFFSGIFFIILLTIDRYLAIVHAV-FALK--ARTVTFGVVTsvvTWVVAVFASLPGIIftKSQKEGSHYTCSPHFPPSQY 157
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 206 NDQK-WYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15184  158 QFWKnFQTLKMNILGLVLPLLVMIICYSGILKTLLRCRN 196
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-203 2.52e-10

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 61.12  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLF---LVSLASADILVATLVIPFSLANEVMGY--WYFGKAWCEIYLALD 128
Cdd:cd15130    6 IYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLAMPVELYNFIWVHhpWAFGDAGCRGYYFLR 85
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQP-PAEPRC 203
Cdd:cd15130   86 DACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDDGThPGGLVC 161
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
54-241 2.68e-10

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 61.04  E-value: 2.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRR--IKAIIvtVWVISAVISFPPLISIEKKGSSGGQP--PAEPRCEINDQK 209
Cdd:cd15183   85 SEIFFIILLTIDRYLAIVHAVFALRARTVTFgiITSII--TWALAILASMPCLYFFKSQWEFTHHTcsAHFPRKSLIRWK 162
                        170       180       190
                 ....*....|....*....|....*....|...
gi 826349104 210 WY-VISSCIGSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd15183  163 RFqALKLNLLGLILPLLVMIICYTGIINILLRR 195
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
57-182 2.92e-10

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 61.03  E-value: 2.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATL--VIPFSLAneVMGYWYFGKAWCEIYLALDVLFCTS 134
Cdd:cd16002    9 VIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFntVINFTYA--IHNEWYYGLEYCKFHNFFPIAAVFA 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 135 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIkaIIVTVWVISAVISFP 182
Cdd:cd16002   87 SIYSMTAIALDRYMAIIHPLQPRLSATATKV--VICVIWVLAFLLAFP 132
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
49-234 3.01e-10

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 60.92  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMG-YWYFGKAWCEIYLAL 127
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLV-IWLPFKIAYHIHGnNWIFGEALCRLVTVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI---SIEKKGSSGGQ-PPAEPRC 203
Cdd:cd15162   80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLvkqTIFLPALDITTcHDVLPEQ 159
                        170       180       190
                 ....*....|....*....|....*....|..
gi 826349104 204 E-INDQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15162  160 LlVGDWFYYFLSLAIVGFLIPFILTASCYVAT 191
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
51-182 3.32e-10

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 60.55  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15398    3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCV 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLkrTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15398   83 SVMVSTLMLMSIAIVRYHMIKHPLSNHL--TANHGYFLLGTVWTLGFTICSP 132
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
57-181 3.68e-10

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 60.70  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15235    9 LAMyLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTD 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15235   89 SFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSL 134
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
45-185 3.84e-10

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 60.71  E-value: 3.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15123    3 IYVTYAVIISVGIL------GNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLL 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15123   77 SFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAV 137
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
57-187 4.08e-10

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 60.61  E-value: 4.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15981    9 FIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSASV 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 137 VHLCAISLDRYWSITQAieYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15981   89 FTLVAIAVERFRCIVHP--FRQKLTLRKAIVTIVIIWVLALIIMCPSAVTL 137
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
48-182 5.96e-10

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 60.13  E-value: 5.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  48 TLTLVCLVGLlmlltvFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
Cdd:cd15000    5 MFLPVVLFGI------FGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFL 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKAIIVTVWVISAVISFP 182
Cdd:cd15000   79 EGSLLLASVLALCAVSYDRLTAIVLPSEARLTK--RGAKIVIVITWIVGLLLALP 131
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
50-234 6.08e-10

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 59.76  E-value: 6.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIiAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMG-YWYFGKAWCEIYLALD 128
Cdd:cd15372    8 TLVFLVGLP------ANGLAL-WVLATQVKRLPSTIFLINLAVADLLLI-LVLPFKISYHFLGnNWPFGEGLCRVVTAFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP--------PLISIEKKGSSGGQPPAE 200
Cdd:cd15372   80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPltlqrqsyPLERLNITLCHDVLPLDE 159
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 201 prceiNDQKWYVISSCIG--SFFAPCLIMILVYVRI 234
Cdd:cd15372  160 -----QDTYLFYYFACLAvlGFLLPLVVILFCYGSV 190
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
47-249 6.13e-10

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 59.78  E-value: 6.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGllmlltVFGNVLVIIaVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVM-GYWYFGKAWCEIYL 125
Cdd:cd15115    5 VVLSLTFLLG------VPGNGLVIW-VAGLKMKRTVNTIWFLNLAVAD-LLCCLSLPFSIAHLLLnGHWPYGRFLCKLLP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGgqppaEPRCEI 205
Cdd:cd15115   77 SIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGN-----HTRCGY 151
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 826349104 206 NDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
Cdd:cd15115  152 DFLVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSQSK 195
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
51-236 8.82e-10

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 59.46  E-value: 8.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVMGyWYFGKAWCEIYLALDV 129
Cdd:cd15186    3 LSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLfVATL--PFWTHYLINE-WGLHNAMCKLTTAFFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI-SIEKKGSSGGQPPaeprcEINDQ 208
Cdd:cd15186   80 IGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMfTKMKENECLGDYP-----EVLQE 154
                        170       180       190
                 ....*....|....*....|....*....|.
gi 826349104 209 KWYVISSC---IGSFFAPCLIMILVYVRIYQ 236
Cdd:cd15186  155 IWPVLRNVelnFLGFLLPLLIMSYCYFRIIQ 185
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
50-249 1.03e-09

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 59.39  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMlltvfgNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMGY-WYFGKAWCEIYLALD 128
Cdd:cd15369    8 TIVFVISLPL------NILALVVFLRKMRVKKPAVIYMLNLACADLLFV-LLLPFKIAYHFSGNdWLFGEAMCRVVTAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSG-GQPPAEPRCEIND 207
Cdd:cd15369   81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDlGITTCHDVLNEQL 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 208 QKWYVI----SSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
Cdd:cd15369  161 LMGYYVyyfsIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSK 206
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
65-182 1.17e-09

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 59.11  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  65 GNVLVIIAVFTSRALKAPQNLF---LVSLASADILVATLVIPFSLANEVMGY--WYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15356   17 GNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFVWFHypWVFGDLVCRGYYFVRDICSYATVLNI 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15356   97 ASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALP 139
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
48-185 1.23e-09

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 58.98  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  48 TLTLVCLvGLLMLLTVFGNVLVI-IAVFtsRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAWCEIYL 125
Cdd:cd15117    1 ILSLVIY-SSAFVLGTLGNGLVIwVTGF--RMTRTVTTVCFLNLAVAD-FAFCLFLPFSVVYTALGFhWPFGWFLCKLYS 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15117   77 TLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLV 136
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
54-233 1.24e-09

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 59.07  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSR-ALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFC 132
Cdd:cd15097    6 VFSLIFLLGTVGNSLVLAVLLRSGqSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLiSIEKKGSSGGQPPAEPRCEINDQKWYV 212
Cdd:cd15097   86 YASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYL-SYYDLIDYANSTVCMPGWEEARRKAMD 164
                        170       180
                 ....*....|....*....|.
gi 826349104 213 ISSCIGSFFAPCLIMILVYVR 233
Cdd:cd15097  165 TCTFAFGYLIPVLVVSLSYTR 185
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
58-178 1.28e-09

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 58.77  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVA------TLVIPFSLANEVMGYWYFgkawCEIYLALDVLF 131
Cdd:cd15353   10 LGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvsngseTVVITLLNGNDTDAQSFT----VNIDNVIDSVI 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAV 178
Cdd:cd15353   86 CSSllaSICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTV 135
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
49-185 1.67e-09

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 58.67  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15395    1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQ 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15395   81 CISITVSIFSLVLIAIERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVLTSLPFLI 135
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
60-185 1.75e-09

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 58.60  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIavFTSRALKAPQN-LFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTSSIV 137
Cdd:cd15119   12 VLGVPGNAIVIW--VTGFKWKKTVNtLWFLNLAIAD-FVFVLFLPLHITYVALDFhWPFGVWLCKINSFVAVLNMFASVL 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 138 HLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15119   89 FLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALY 136
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
49-185 1.80e-09

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 58.72  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15084   11 LTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMV 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAI-EYNLKRtpRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15084   91 SLTGIVGLWSLAILAFERYLVICKPMgDFRFQQ--RHAVSGCAFTWGWSLLWTSPPLF 146
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
47-262 2.01e-09

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 58.65  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLvgLLMLLTVFGNVLVIIAVFT---SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG--YWYFGKAWC 121
Cdd:cd15135    1 ITLTLLYS--LILVAGILGNSATIKVTQVlqkKGYLQKSVTDHMVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIAC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 122 EIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYnLKRTPRRIKAIIVTVWVISAVISFPPLIS------IEKKGSSGG 195
Cdd:cd15135   79 KIYNFLFEACSYATILNVATLSFERYIAICHPFKY-KALSGSRVRLLICFVWLTSALVALPLLFAmgtedpLEAFPSYRG 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 196 QPPAEPR-------CEINDQKWYVISSCIgsfFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAATAPPGGTE 262
Cdd:cd15135  158 TRHHCQDqksnltiCTSLSSKWTVFQASI---FSAFVLYLLVLASVAFMCRRMMRALMGSKKGAVAVKGPGGSV 228
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
51-240 2.18e-09

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 58.02  E-value: 2.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTvfgNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIpfslANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15962    6 MLCISGTVIACE---NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLI----LNFVFQYVIQSETISLITVGFLVA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINdqkw 210
Cdd:cd15962   79 SFTASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGWNCLEERASCSIVRPLTKSN---- 154
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 211 yvISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Cdd:cd15962  155 --VTLLSASFFFIFILMLHLYIKICKIVCR 182
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
51-205 2.24e-09

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 58.33  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15127    3 VMCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVA 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQA-IEYNLKRTPRRIKAIIVTVWVISAVISFPPLI--SIEKKGSSGGQPPAEpRCEI 205
Cdd:cd15127   83 SLGVTTFTLCALCIDRFRAATNVqMYYEMIENCTSTTAKLAVIWVGALLLALPEVVlrQLSKEDGGSGAPPAE-RCVV 159
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
56-185 2.48e-09

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 58.24  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGyWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15179    8 SIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLF-VLTLPFWAVDAAAN-WYFGNFLCKAVHVIYTVNLYSS 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 136 IVHLCAISLDRYWSITQAIeyNLKRtPRRI---KAIIVTVWVISAVISFPPLI 185
Cdd:cd15179   86 VLILAFISLDRYLAIVHAT--NSQR-PRKLlaeKVVYVGVWLPALLLTVPDLV 135
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
66-185 4.42e-09

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 57.34  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  66 NVLVIIAVFTSRALKAPQNLFLVSLASADILVAT-LVIPFSLAnevmgYWYFGKAWCEIYLALDVLFCTSSIVHLCAISL 144
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIgLILNFIFA-----YLLQSEAAKLVTVGLIVASFSASVCSLLAITV 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 826349104 145 DRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15961   93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVM 133
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
57-182 6.76e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 56.68  E-value: 6.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTS 134
Cdd:cd15191    9 IIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLfLATL--PLWATYYSYGYnWLFGSVMCKICGSLLTLNLFA 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 135 SIVHLCAISLDRYwsitQAIEYNLK---RTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15191   87 SIFFITCMSVDRY----LAVVYPLRsqrRRSWQARLVCLLVWVLACLSSLP 133
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
56-182 6.89e-09

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 56.83  E-value: 6.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15124    8 GIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15124   88 VFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIP 134
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
51-185 7.73e-09

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 56.34  E-value: 7.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-------------YWYF 116
Cdd:cd15912    2 LLFLLLLLTyLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGkktisfagcfaqsFFYF 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 117 gkawceiylaldvLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15912   82 -------------FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
48-182 8.40e-09

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 56.81  E-value: 8.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  48 TLTLVCLVGLLMlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL---ANEVMGYWYFGKAWCEIY 124
Cdd:cd15006    4 TVQVVIFVGSLL-----GNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIvlsASPHCCWWIYTLLFCKVI 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRikAIIVTVWVISAVISFP 182
Cdd:cd15006   79 KFLHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSR--DLVIYIWAHAVVASVP 134
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
51-231 9.30e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 56.40  E-value: 9.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCeIYLALDVL 130
Cdd:cd15085    3 LSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFC-IFQGFAVN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FctSSIVHLCAISL---DRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQppaePRCEI-- 205
Cdd:cd15085   82 Y--FGIVSLWSLTLlayERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQ----TSCSIgw 154
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 206 NDQKW----YVISSCIGSFFAPCLIMILVY 231
Cdd:cd15085  155 EERSWsnysYLILYFLMCFVIPVAIIGFSY 184
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
57-234 9.44e-09

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 56.69  E-value: 9.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKA-PQNLFLVSLASADI-LVATLviPFSLANEVMGY-WYFGKAWCEIYLALDVLFCT 133
Cdd:cd15190   19 LVFVLGLSGNGLVLWTVFRSKRKRRrSADTFIANLALADLtFVVTL--PLWAVYTALGYhWPFGSFLCKLSSYLVFVNMY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISiekKGSSGGQPPAEPRCEI-------N 206
Cdd:cd15190   97 ASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALIL---RTTSDLEGTNKVICDMdysgvvsN 173
                        170       180       190
                 ....*....|....*....|....*....|...
gi 826349104 207 DQKWY-----VISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15190  174 ESEWAwiaglGLSSTVLGFLLPFLIMLTCYFFI 206
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
51-186 1.12e-08

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 56.26  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDV 129
Cdd:cd15161    3 FALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVAD-LSYVLILPMRLVYHLSGnHWPFGEVPCRLAGFLFY 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS 186
Cdd:cd15161   82 LNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVS 138
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
57-189 1.16e-08

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 56.14  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANevmgYWY------FGKAWCEIYLaLDVL 130
Cdd:cd15221    9 SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAI----FWFgageisFDGCLTQMFF-VHFV 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 131 FCTSSIVhLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEK 189
Cdd:cd15221   84 FVTESAI-LLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKR 141
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
45-234 1.40e-08

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 56.02  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEV-MGYWYFGKAWCEI 123
Cdd:cd15194    3 LPILYCLVFLVGAV------GNAILMGALVFKRGVRRLIDIFISNLAASD-FIFLVTLPLWVDKEVvLGPWRSGSFLCKG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRC 203
Cdd:cd15194   76 SSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAG 155
                        170       180       190
                 ....*....|....*....|....*....|.
gi 826349104 204 EINDQKWYVIsSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15194  156 TPSKVIFSLV-SLIVAFFLPLLSILTCYCTI 185
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
60-251 1.97e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 55.28  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT-LVIPFSLANEVMG-YWYFGKAW-----CEIYLALDVLFC 132
Cdd:cd15137   12 IIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVyLLIIASVDLYYRGvYIKHDEEWrsswlCTFAGFLATLSS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITqaieYNLKR---TPRRIKAIIVTVWVISAVISFPPLISIEKK----GSSGgqppaepRC-- 203
Cdd:cd15137   92 EVSVLILTLITLDRFICIV----FPFSGrrlGLRRAIIVLACIWLIGLLLAVLPLLPWDYFgnfyGRSG-------VClp 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 204 -EINDQK---W-YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGP 251
Cdd:cd15137  161 lHITDERpagWeYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSK 213
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-185 2.25e-08

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 55.23  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKA-PQNLFLVSLASADILVATlvipFSLANEVMGYWYFGKAWCEIYL----ALDVLF 131
Cdd:cd15099    9 LAGPVTFLENILVLLTILSSTALRRrPSYLFIGSLALADMLASV----IFTISFLDFHVFHQRDSRNLFLfklgGVTMAF 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 826349104 132 cTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15099   85 -TASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLM 137
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
50-234 2.94e-08

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 54.83  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15185    8 SLVFIVGLL------GNVVVVVILIKYRRLRIMTNIYLLNLAISDLLF-LFTLPFWIHYVRWNNWVFGHGMCKLLSGFYY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGG---QPPAEPRCEIN 206
Cdd:cd15185   81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEflcSPLYPEDTEDS 160
                        170       180
                 ....*....|....*....|....*...
gi 826349104 207 DQKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15185  161 WKRFHALRMNIFGLALPLLIMVICYTGI 188
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
50-239 3.92e-08

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 54.40  E-value: 3.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYlALDV 129
Cdd:cd15075    2 ILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLE-GFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCtsSIVHLCA---ISLDRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFPPLI-----SIEKKGSSGGqPPAEP 201
Cdd:cd15075   81 AFF--GIAALCTvavIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLWSLIWNTPPLFgwgsyQLEGVMTSCA-PDWYS 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 202 RCEINDQkwYVISSCIGSFFAPCLIMILVYVR----IYQIAK 239
Cdd:cd15075  157 RDPVNVS--YILCYFSFCFAIPFAIILVSYGYllwtLRQVAK 196
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
51-236 4.10e-08

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 54.42  E-value: 4.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15082   16 LAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTF 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPR---CEIND 207
Cdd:cd15082   96 FGIVALWSLAVLAFERFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNwysGNMHD 174
                        170       180
                 ....*....|....*....|....*....
gi 826349104 208 QKwYVISSCIGSFFAPCLIMILVYVRIYQ 236
Cdd:cd15082  175 HT-YIITFFTTCFILPLGVIFVSYGKLLQ 202
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-188 4.14e-08

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 54.47  E-value: 4.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVgllMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15976    2 INTVVSCLV---FVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIE 188
Cdd:cd15976   79 IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFD 140
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
66-177 4.59e-08

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 54.02  E-value: 4.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  66 NVLVIIAVFTSRALKAPQNLFLVSLASADILVA---TL-VIPFSLANevMGYWYF-GKAWCEIYLALDVLFCTS---SIV 137
Cdd:cd15350   18 NLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSlykTLeNILIILAD--MGYLNRrGPFETKLDDIMDSLFCLSllgSIF 95
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 826349104 138 HLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISA 177
Cdd:cd15350   96 SILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCG 135
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
43-182 6.83e-08

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 53.61  E-value: 6.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEV-MGYWYFGKAWC 121
Cdd:cd14987    1 YTLSFFYIFIFVIGLL------ANSVVVWVNLQAKRTGYETHLYILNLAIADLCV-VATLPVWVVSLVqHNQWPMGEFTC 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 826349104 122 EI-YLALDV-LFctSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd14987   74 KItHLIFSInLF--GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLP 134
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
58-180 6.86e-08

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 53.64  E-value: 6.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYL---ALDVLFCTS 134
Cdd:cd15351   10 LGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHmdnVIDTMICSS 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 135 ---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS 180
Cdd:cd15351   90 vvsSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSS 138
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
57-188 7.12e-08

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 54.63  E-value: 7.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRaLKAPQNLFLVSLASADiLVATLVIPFSLANEvMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:PHA02638 107 IIFILGLFGNAAIIMILFCKK-IKTITDIYIFNLAISD-LIFVIDFPFIIYNE-FDQWIFGDFMCKVISASYYIGFFSNM 183
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIE 188
Cdd:PHA02638 184 FLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFE 235
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
85-234 8.07e-08

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 53.64  E-value: 8.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  85 LFLVSLASADILVaTLVIPFSLANEV-MGYWYFGKAWCEIYlalDVLFCTS---SIVHLCAISLDRYWSITQAIE----Y 156
Cdd:cd15969   36 FYLKNIVIADLLM-TLTFPFKIIQDSgLGPWNFNFFLCRYT---SVLFYASmytSIVFLGLISLDRYLKVVKPFGdsrmY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 157 NLKRTprriKAIIVTVWVISAVISFPPLIsiekkgSSGGQPPAEprcEIND---------QKWYV----ISSCIgsFFAP 223
Cdd:cd15969  112 SITFT----KVLSACVWLIMAFLSLPNII------LTNGQPTED---NIHDcsklksplgVKWHTavsyINICI--FVAV 176
                        170
                 ....*....|.
gi 826349104 224 CLIMILVYVRI 234
Cdd:cd15969  177 LVILIVCYISI 187
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
43-181 8.59e-08

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 53.59  E-value: 8.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCE 122
Cdd:cd15945   10 LSLKVTLFLVFL--LVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCA 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15945   88 LQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSL 146
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
54-245 9.76e-08

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 53.26  E-value: 9.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFC 132
Cdd:cd15199    6 LLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLL-ICLPFKAYFYLNGnRWSLGGGTCKALLFMLSLSR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqPPAEPRCEIN-DQKWY 211
Cdd:cd15199   85 GVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTEC-NSFSPKDDEDfSDTWQ 163
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 212 VISSCIgSFFAPCLIMILVYVRIYQIAKRRTRVP 245
Cdd:cd15199  164 EAVFFL-QFLLPFGLIVFCTVRIIRRLKKRLRDV 196
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
60-180 1.01e-07

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 53.00  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15918   12 LVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS 180
Cdd:cd15918   92 AVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHS 132
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
66-232 1.12e-07

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 53.26  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  66 NVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCTSSIVHLCAISL 144
Cdd:cd15370   18 NAMALWVFLFRTKKKHPAVIYMANLALADLL-FVIWFPLKIAYHINGnNWIYGEALCKVLIGFFYGNMYCSILFMTCLSV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 145 DRYWSITQAIEYNlKRTPRRIKAIIVTVWVISAVISFP-----PLISIEKKGSSGGQPPAEPRCEINDQKWYVISSCIGS 219
Cdd:cd15370   97 QRYWVIVNPMSHS-RKKANIAIGISLAIWLLILLVTIPlylvkQTVFIPALDITTCHDVLPEQLLVGDMFNYFLSLAIGV 175
                        170
                 ....*....|...
gi 826349104 220 FFAPCLIMILVYV 232
Cdd:cd15370  176 FLFPAFLTAVAYV 188
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
51-235 1.12e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 52.99  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRaLKAPQNLFLVS-LASAD----ILVATL-VIPFSLANEVMGY---WYFGkAWC 121
Cdd:cd15136    3 LRIGVWFVFLLALVGNIIVLLVLLTSR-TKLTVPRFLMCnLAFADfcmgIYLGLLaIVDAKTLGEYYNYaidWQTG-AGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 122 EIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEp 201
Cdd:cd15136   81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFE- 159
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 202 rCEINDQKWYVISSCIGSFFAPCLIMILvYVRIY 235
Cdd:cd15136  160 -TETPVSKAYVIFLLLFNGLAFLIICGC-YIKIY 191
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
65-188 1.52e-07

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 52.85  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  65 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTSSIVHLCAIS 143
Cdd:cd14988   17 ENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVWMLEVMLDYtWLWGSFLCKFTHYFYFANMYSSIFFLTCLS 95
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 144 LDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIE 188
Cdd:cd14988   96 VDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQ 140
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
51-249 1.58e-07

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 52.48  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTvfgNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT-LVIPFslaneVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15100    6 VLCVSGTLIACE---NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLgLILHF-----VFRYCVYSEALSLVSVGLLV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINdqk 209
Cdd:cd15100   78 AAFSASVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLREGSSCSVVRPLTKNH--- 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 826349104 210 wyvISSCIGSFFAPCLIMILVYVRI--------YQIAKRRTRVPPSRR 249
Cdd:cd15100  155 ---LAVLAVAFLLVFALMLQLYAQIcrivlrhaHQIALQRHFLAPSHY 199
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
51-248 1.96e-07

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 52.50  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLvIIAVFTSRALKAPQNLFLVSLASADILvATLVIP-FSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15118    3 TICLHGIVSTLGIVENLL-ILWVVGFRLRRTVISIWILNLALSDLL-ATLSLPfFTYYLASGHTWELGTTFCRIHSSIFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI---SIEKKGS-----------SGG 195
Cdd:cd15118   81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVfrdVIERKDGrklcyynfalfSPS 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 196 QPPAEPRCEINdQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSR 248
Cdd:cd15118  161 PDNNHPICKQR-QEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGR 212
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
51-242 2.04e-07

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 52.14  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15078    3 LALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIivtvWVISAVISFPPLI-------SIEKKGSSGGQPPAEPrc 203
Cdd:cd15078   83 FGIVSIMTLTVLAYERYIRVVHAKVVNFSWSWRAITYI----WLYSLAWTGAPLLgwnrytlEVHGLGCSFDWKSKDP-- 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 204 eiNDQKwYVISSCIGSFFAPCLIMILVYVRI-YQIAKRRT 242
Cdd:cd15078  157 --NDTS-FVLLFFLGCLVVPLGIMAYCYGHIlYEIRMLRS 193
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
393-452 2.09e-07

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 52.19  E-value: 2.09e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 393 VVIGVFVVCWFPFFFtYTLTAVGCSVPR--TLFK--FFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15346  215 IVLSVFIACWAPLFI-LLLLDVGCKVKTcsILFKaeYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
50-184 2.44e-07

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 52.00  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFslaneVMGY------WYFGKAWCEI 123
Cdd:cd15967    8 ILVFVVGLV------GNVWGLKSLLANWKKLGNINVFVLNLGLADLLY-LLTLPF-----LVVYylkgrkWIFGQVFCKI 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL 184
Cdd:cd15967   76 TRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDL 136
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
393-452 2.49e-07

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 51.74  E-value: 2.49e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 393 VVIGVFVVCWFPFFfTYTLTAVGCSVPR--TLFK--FFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15347  204 IVLGVFIVCWLPAF-IILLLDTSCKVKScpILYKadYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
380-452 2.83e-07

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 51.70  E-value: 2.83e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 380 RQNREKRFTFVLAVVIGVFVVCWFPFFfTYTLTAVGCSVPR--TLFK--FFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15102  195 ASPRSLALLKTVLIVLLVFIACWGPLF-ILLLLDVACPVKTcpILYKadWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-197 2.89e-07

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 52.16  E-value: 2.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQ---NLFLVSLASADILVATLVIPFSLANEVMGY--WYFGKAWC 121
Cdd:cd15355    1 VLVTAIYL--ALFVVGTVGNSITLYTLARKKSLQHLQstvHYHLASLALSDLLILLLAMPVELYNFIWVHhpWAFGDAAC 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 122 EIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQP 197
Cdd:cd15355   79 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQNRSGTHP 154
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
57-235 3.08e-07

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 51.68  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEV-MGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15167    9 LIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLL-TLALPVKIAVDLgIAPWKLKIFHCQVTACLIYINMYLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP----PLISIEKKGSSGGqppAEPRCEINdQKWY 211
Cdd:cd15167   88 IIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPnmaiPIKTIEEKPGVGC---ADFKTEFG-RHWH 163
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 212 VISS--CIGSFF-APCLIMI---LVYVRIY 235
Cdd:cd15167  164 VLTNfiCMAIFLnFSAIILIsnfLVIRKLY 193
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-185 3.19e-07

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 51.76  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILvATLVIPFSLaneVMGYWYFGKAWCEIYL-- 125
Cdd:cd15341    1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLrRKPSYLFIGSLALADFL-ASVVFACSF---VDFHVFHGVDSSAIFLlk 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 126 --ALDVLFcTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15341   77 lgGVTMSF-TASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLM 137
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
393-452 3.23e-07

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 51.74  E-value: 3.23e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 393 VVIGVFVVCWFPFFFTYtLTAVGCSVPR--TLFK--FFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15345  208 IVVGVFIACWSPLFILL-LIDVACEVKQcpILYKadWFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
50-187 3.58e-07

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 51.46  E-value: 3.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDV 129
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 130 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM 139
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
57-235 3.98e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 51.45  E-value: 3.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCeIYLALDVLFC-TSS 135
Cdd:cd15081   21 FVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMC-VLEGFTVSVCgITG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKW----Y 211
Cdd:cd15081  100 LWSLTIISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPgvqsY 178
                        170       180
                 ....*....|....*....|....
gi 826349104 212 VISSCIGSFFAPCLIMILVYVRIY 235
Cdd:cd15081  179 MIVLMITCCIIPLAIIILCYLQVW 202
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
46-185 4.73e-07

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 51.44  E-value: 4.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  46 QVTLTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKApQNLFLVSLASADILVaTLVIPFSLANEvMGYWYFGKAWCEIYL 125
Cdd:PHA02834  26 DVNYFVIVFYILLFIFGLIGNVLVIAVLIVKRFMFV-VDVYLFNIAMSDLML-VFSFPFIIHND-LNEWIFGEFMCKLVL 102
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIkAIIVTVWVISAVISFPPLI 185
Cdd:PHA02834 103 GVYFVGFFSNMFFVTLISIDRYILVVNATKIKNKSISLSV-LLSVAAWVCSVILSMPAMV 161
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
52-185 4.85e-07

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 51.05  E-value: 4.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMlltVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIpfslANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15960    7 LCVTGTVM---ACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLI----ANFVAIYVMNSEAVTLCSAGLLLAA 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15960   80 FSASVCSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAM 133
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
58-147 5.03e-07

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 50.82  E-value: 5.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT--LVIPFSlanEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15072   10 EALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLnaLVAASS---SLLRRWPYGSEGCQAHGFQGFFTALAS 86
                         90
                 ....*....|..
gi 826349104 136 IVHLCAISLDRY 147
Cdd:cd15072   87 ICSSAAIAWDRY 98
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-188 6.17e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 51.06  E-value: 6.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVgllMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15977    2 VNTILSCVI---FLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 127 LDVLFCTSSIVHLCAISLDRY-----WSITQAIEYNLKrtprriKAIIVTV-WVISAVISFPPLISIE 188
Cdd:cd15977   79 IQKASVGITVLSLCALSIDRYravasWSRIRGIGIPVW------KAVEVTLiWAVAIIVAVPEAIAFD 140
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
51-244 6.97e-07

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 50.65  E-value: 6.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVI-------PFSLANEVMGyWYFGKAWCEI 123
Cdd:cd15343    3 VLCVGTFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVflmfntgPVSKTLTVNR-WFLRQGLLDT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLaldvlfcTSSIVHLCAISLDRYWSITQ-AIEYNLkrTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPr 202
Cdd:cd15343   82 SL-------SASLTNLLVIAVERHISIMRmKVHSNL--TKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISACSSLAP- 151
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 203 ceINDQKWYVISSCigSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15343  152 --IYSRSYLVFWSV--SNLVVFLIMVVVYLRIYVYVQRKTNV 189
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
50-181 7.11e-07

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 50.44  E-value: 7.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15416    1 IILFVLFLVIySVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNAL 133
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
57-185 7.19e-07

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 50.54  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVC-CLPFWAINISNGFnWPFGEFLCKSVNAVIYMNLYSS 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15381   88 IYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIV 137
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
54-182 7.95e-07

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 50.59  E-value: 7.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVF-----GNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15121    1 QLGIAILSLAFilgfpGNLFVVWSVLCRMKKRSVTCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKLCHYVC 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15121   80 GVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLP 133
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-187 8.22e-07

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 50.17  E-value: 8.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-------------YWYF 116
Cdd:cd13954    2 LLFVLFLLIyLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGdktisfsgcltqlYFFF 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 117 GKAWCEIYLaldvlfctssivhLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd13954   82 SLGGTECFL-------------LAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLI 139
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
66-240 8.85e-07

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 50.27  E-value: 8.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  66 NVLVIIAVFTSRALKAPQNLFLVSLASADILVAT-LVIPFSLAnevmgYWYFGKAWCEIYLALDVLFCTSSIVHLCAISL 144
Cdd:cd15963   18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLgLILHFAFV-----YCIQSAPVNLVTVGLLAPSFTASVSSLLAITI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 145 DRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINdqkwyvISSCIGSFFAPC 224
Cdd:cd15963   93 DRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKDPSTCSVVKPLTKNH------LVILSISFFMVF 166
                        170
                 ....*....|....*.
gi 826349104 225 LIMILVYVRIYQIAKR 240
Cdd:cd15963  167 ALMLQLYAQICRIVCR 182
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
57-181 9.16e-07

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 50.38  E-value: 9.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15915    9 LLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEA 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15915   89 MLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHAL 133
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
43-240 9.79e-07

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 50.08  E-value: 9.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLVGL-LMLLTVFGNVLVIIAvftSRALkapqNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAW 120
Cdd:cd15160    1 IFLPVVYSFVFVVGLpANCLALWVLYLQIKK---ENVL----GVYLLNLSLSD-LLYILTLPLWIDYTANHHnWTFGPLS 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 121 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSggqpPAE 200
Cdd:cd15160   73 CKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDE----PNH 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 201 PRC--EINDQKWYV----ISSCIGsFFAPCLIMILVYVRIYQIAKR 240
Cdd:cd15160  149 TLCyeKYPMEGWQAsynyARFLVG-FLIPLSLILFFYRRVLRAVRQ 193
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
46-242 1.11e-06

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 50.13  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  46 QVTLTLVCLVGLLMLltvFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEV-MGYWYFGKAWCEI 123
Cdd:cd15158    1 QVYSTLYSVITVFGL---VGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLcVCTL--PLRVVYYVhKGQWLFGDFLCRI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 -YLALDV-LFCtsSIVHLCAISLDRYWSITQAIEyNLKR-TPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGG----Q 196
Cdd:cd15158   76 sSYALYVnLYC--SIYFMTAMSFTRFLAIVFPVQ-NLNLvTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKtkcfE 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 197 PPAEPRCEINDQKWYVISSCIGsFFAPCLIMILVYVRIYQIAKRRT 242
Cdd:cd15158  153 PPQSNQQLTKLLVLNYISLVVG-FIIPFLVILICYAMIIRTLLKNT 197
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
59-185 1.89e-06

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 49.39  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  59 MLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMG-YWYFGKAWCEI--YLALDVLFCtsS 135
Cdd:cd15968   11 FLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYA-LSLPLLIYNYAMRdRWLFGDFMCRLvrFLFYFNLYG--S 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15968   88 ILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILI 137
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
49-241 1.90e-06

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 49.38  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT---LVIPFSLANEVmgyWYFGKAWCEIYL 125
Cdd:cd15200    7 LGIEFVLGLV------GNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIInlpFRIDYYLRNEV---WRFGATACQVNL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAiEYNLKRTPRRIKA-IIVTVWVISAVISFPPLIS-IEKKGSS--GGQPPAEP 201
Cdd:cd15200   78 FMLSMNRTASIVFLTAIALNRYLKVVHP-HHQLSKASVGCAAkVAAGLWILILLLNIHLLLLdHVQSNSTclSYDHGTDP 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 202 RCEindQKWYVISSCIgSFFAPCLIMILVYVRIYQIAKRR 241
Cdd:cd15200  157 SAS---DRWHRILFFL-EFFLPLGIILFCIFSIILTLKQR 192
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-185 2.12e-06

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 49.39  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPF---SLANEVMgyWYFGKAWCEIYLALD 128
Cdd:cd15189   10 LCLFGLL------GNLFVLLVFLLHRRRLTVAEIYLGNLAAAD-LVFVSGLPFwamNILNQFN--WPFGELLCRVVNGVI 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15189   81 KVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFL 137
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
50-234 2.23e-06

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 49.02  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMGY-WYFGKAWCEIYLALD 128
Cdd:cd15371    1 KLIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTAIFYANLAISDLLFC-ITLPFKIVYHLNGNnWVFGETMCRIITITF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRIKAIIV--TVWVISAVISFPplISIEKKGSSGGQP------PAE 200
Cdd:cd15371   80 YGNMYCSILLLTCISINRYLAIVHPFIY--RSLPKKTYAVLIcaLVWTIVFLYMLP--FFILKQTYYLKELnittchDVL 155
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 826349104 201 PRCEIND--QKWYVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15371  156 PECEQNSnfQFYYFISMAVFGFLIPLVITIFCYISI 191
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
105-249 2.50e-06

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 49.01  E-value: 2.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 105 SLANEVMGYWYFgkawCEIYLaldvlfctsSIVHLCAISLDRYWSITQAIEYNLKRTpRRIKAIIVTVWVISAVISFPPL 184
Cdd:cd15364   70 SLACKITGYIFF----CNIYI---------SILLLCCISIDRFVAVVYALESRGRRR-QRIAAFISFLIFIVVGLVHSPV 135
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 185 ISIEKKGSSGGQPPAEPrCEINDQ--KWYVISSCIGsFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
Cdd:cd15364  136 FIMREGQTEGSHTCFET-LQMDTQvaGFYYARFCIG-FAIPLAILIFTNYRIFRSIQTSTSLTPHQK 200
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
52-182 2.99e-06

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 48.64  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKAWCEIYLALDVL 130
Cdd:cd15380   10 ICFFGLL------GNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPFWAENIRNQFnWPFGNFLCRVISGVIKA 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15380   83 NLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIP 134
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
57-182 3.04e-06

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 48.83  E-value: 3.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANevmgYWY------FGKAWCEIYlALDVL 130
Cdd:cd15223    9 LLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAI----FWFdantisLPGCFAQMF-FIHFF 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 131 FCTSSIVHLCaISLDRYWSITQAIEYNLKRTPRRI-KAIIVTVwVISAVISFP 182
Cdd:cd15223   84 TAMESSILLV-MALDRYVAICKPLRYPSIITKSFIlKLVLFAL-IRSGLLVLP 134
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
60-187 3.13e-06

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 48.58  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWC--EIYLALDvLFCTSSIV 137
Cdd:cd15424   12 LLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCttQMYIALS-LGSTECLL 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 138 hLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15424   91 -LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCT 139
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
57-182 3.28e-06

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 48.61  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMGY-WYFGKAWCEIylaLDVLFCT-- 133
Cdd:cd15368    9 LVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLAC-FLPFQIVYHIQRNhWIFGKPLCNV---VTVLFYAnm 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 -SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15368   85 ySSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSP 134
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
45-220 3.36e-06

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 48.61  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLMlltvfgNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15154    3 HLVGYSLLFPVGLLL------NAVALWVFVRYLRLHSVVSIYMCNLALSDLLF-TLSLPLRIYYYANHYWPFGNFLCQFS 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKgssggqppaepRCE 204
Cdd:cd15154   76 GSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSS-----------DCL 144
                        170
                 ....*....|....*.
gi 826349104 205 INDQKwyvISSCIGSF 220
Cdd:cd15154  145 LHGEK---VYRCFESF 157
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
60-190 3.52e-06

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 48.61  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANevmgYWY------FGKAWCEIYLaLDVLFCT 133
Cdd:cd15955   12 LLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAI----FWFqlreisFNACLAQMFF-IHTLQAF 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 134 SSIVhLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKK 190
Cdd:cd15955   87 ESGI-LLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKLR 142
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-185 3.60e-06

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 48.67  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS- 135
Cdd:cd15128    9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGDQPFGQFLCKLVPFIQKAs 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 136 ----IVHLCAISLDRY-----WSITQAIEynlkrTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15128   89 vgitVLNLCALSVDRYravasWSRIQGIG-----IPMWTAVEIVMIWMLSAVLAVPEAI 142
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
378-451 3.76e-06

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 48.28  E-value: 3.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 378 RGRQNREKRFTFVL---AVVIGVFVVCWFPFF----FTYTLTAVGCSVprtLFK--FFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd15348  197 KGRARRSQKYLALLktvTIVLGTFVACWLPLFllllLDVSCPAQACPV---LLKadYFLGLAMINSLLNPIIYTLTSRDM 273

                 ...
gi 826349104 449 RRA 451
Cdd:cd15348  274 RRA 276
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
65-185 4.24e-06

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 48.32  E-value: 4.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  65 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS-----IVHL 139
Cdd:cd15975   17 GNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFDDSSFGVFLCKLVPFLQKAsvgitVLNL 96
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 140 CAISLDRY-----WSITQAIEYNLkrtprrIKAI-IVTVWVISAVISFPPLI 185
Cdd:cd15975   97 CALSVDRYravasWSRVQGIGIPL------ITAIeIFSIWVLSFILAIPEAI 142
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
81-249 4.25e-06

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 48.41  E-value: 4.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  81 APQNLFLVSLASADILVaTLVIPFSLANEVMGY-WYFGKAWCEiyLALDVLFCT--SSIVHLCAISLDRYWSITQAIEYN 157
Cdd:cd15170   34 TPIDILLLNLTVSDLIF-LLFLPFKMAEAASGMiWPLPYFLCP--LSSFIFFSTiyISTLFLTAISVERYLGVAFPIKYK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 158 LKRTPRRIKAIIVTVWVISAVISFPPLIsIEKKGSSGGQPPAEP-RCEIN---DQKWYVI----SSCIGSFFAPCLIMIL 229
Cdd:cd15170  111 LRRRPLYAVIASVFFWVLAFSHCSIVYI-VEYHIDSENTSVTNNsRCYDNftpEQLKILLpvrlELFLVLFCIPFLITCF 189
                        170       180
                 ....*....|....*....|
gi 826349104 230 VYVRIYQIAKRRTRVPPSRR 249
Cdd:cd15170  190 CYINFIRILSSLPHISRQRK 209
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
57-184 4.55e-06

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 48.03  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPfslanEVMGYWYFGKAWCEIYLALDVLFC--TS 134
Cdd:cd15953    9 LMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVP-----KALCIFWFNLKEITFSGCLTQMFFihTL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 135 SIVH---LCAISLDRYWSITQAIEYNLKRTPRRIkAIIVTVWVISAVISFPPL 184
Cdd:cd15953   84 SIMEsavLVAMAFDRYVAICNPLRYATILTNSRI-AKLGLVGLIRGVLLILPL 135
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
44-192 7.25e-06

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 47.49  E-value: 7.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  44 SLQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEV-MGYWYFgkawCE 122
Cdd:cd15920    2 TLPVMYSIICIVGLL------SNTLALWVFFLRQQRETSISVYMRNLALADLLLV-LCLPFRVAYQNtAGPLSF----CK 70
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 123 IYLALDVLFCTSSIVHLCAISLDRYWSITQAIE-YNLKRTPRRIKAIIVtVWVISAVISFPPLISIEKKGS 192
Cdd:cd15920   71 IVGAFFYLNMYASILFLSLISLDRYLKIIKPLQqFKIHTVPWSSAASGG-VWLLLLACMIPFLFESRNEGP 140
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
57-185 7.31e-06

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 47.55  E-value: 7.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVF-----GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15126    4 LLLALVVFavgivGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTS 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEynlkrTPRRIK------AIIVTVWVISAVISFPPLI 185
Cdd:cd15126   84 LGVTTFSLCALGIDRFHAATSPQP-----KARPVErcqsilAKLAVIWVGSMTLAVPELL 138
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
53-182 7.86e-06

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 47.54  E-value: 7.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  53 CLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFC 132
Cdd:cd15156    5 CVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLF-VFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15156   84 YGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLP 133
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
57-234 7.88e-06

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 47.45  E-value: 7.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15227    9 LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF------------------------PPLISIekkgs 192
Cdd:cd15227   89 ALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGAlhtantfslpfcgsnvihqffcdiPQLLKL----- 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 826349104 193 sggqppAEPRCEINDQKWYVISSCIGSFfapCLIMILV-YVRI 234
Cdd:cd15227  164 ------SCSDTYLNEIGVLVLSVCLGLG---CFVFIIVsYVHI 197
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
45-249 8.59e-06

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 47.44  E-value: 8.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLMlltvfgNVLVIIAVFTSRAlKAPQNLFLVSLASADILVaTLVIPFS-LANEVMGYWYFGKAWCEI 123
Cdd:cd15924    3 FPVLYTVIFFAGILL------NGLAMWIFFHIPS-KSSFIIYLKNTVVADLLM-ILTFPFKiLSDAGLGPWQLRTFVCRV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEkkgssggQPPAEP-- 201
Cdd:cd15924   75 TSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTN-------QQPREKnv 147
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 202 ------RCEINdQKWYVISS--CIGSFFAPCLIMILVYV----RIYQIAKRRTRVPPSRR 249
Cdd:cd15924  148 kkcsflKSELG-LKWHEIVNyiCQVIFWIVFLLMIVCYTaitkKVYRSYRRVFRSSSSRR 206
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
45-252 8.79e-06

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 47.38  E-value: 8.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILvatLVI--PFSLANEVMG-YWYFGKAWC 121
Cdd:cd15148    3 LAVFYSLIFLFGLV------GNLLALWVFLFIHRKRNSVRIFLINVAIADLL---LIIclPFRILYHVNNnQWTLGPLLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 122 EIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVIsAVISFPPLISIEKKGSSGGQppaep 201
Cdd:cd15148   74 KVVGNLFYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAV-ALVGFVPMIVLTEKNEESTK----- 147
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 202 rC----EINDQKWYVISSCI--GSFFAPCLIMILVYVRiyqIAKRRTRVppSRRGPD 252
Cdd:cd15148  148 -CfqykDRKNAKGKAIFNFLivAMFWLVFLLLILSYGK---IAKKLLRI--SRDKPD 198
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
57-176 9.79e-06

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 47.04  E-value: 9.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVF-TSRALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd14983    9 LTILLGLPSNLLALYAFVnRARLRLTPNVIYMINLCLSD-LVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLYAS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVIS 176
Cdd:cd14983   88 TCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALV 128
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
48-185 1.27e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 46.63  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  48 TLTLVCLvGLLMLLTVFGNVLVIiAVFTSRALKAPQNLFLVSLASADILvATLVIPFsLANEVM--GYWYFGKAWCEIYL 125
Cdd:cd15114    1 VVALVLY-AVVFLVGVPGNALVA-WVTGFEAKRSVNAVWFLNLAVADLL-CCLSLPI-LAVPIAqdGHWPFGAAACKLLP 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15114   77 SLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFI 136
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
52-250 1.41e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 46.69  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEYNLKRTpRRIKAIIVTVWVISAVISFPPLISIEK-KGSSGGQPPAEPRCEINDQKW 210
Cdd:cd15388   84 MFASSYMIVAMTFDRHQAICRPMVTFQKGR-ARWNGPVCVAWAISLILSLPQVFIFSKvEVAPGVYECWACFIEPWGLKA 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG 250
Cdd:cd15388  163 YVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIV 202
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
52-182 1.49e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 46.74  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLF 131
Cdd:cd15385    4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLG 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 132 CTSSIVHLCAISLDRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15385   84 MFASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILSTP 133
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
45-178 1.64e-05

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 46.70  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVglLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15944   12 MQIILFVVFLI--IYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQ 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAV 178
Cdd:cd15944   90 FAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLV 143
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
380-452 1.75e-05

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 46.28  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 380 RQNREKRFTFVLAVVIGvFVVCWFPFF---FTYTLTAVG----CSVP---RTLFKFFFWFGYCNSSLNPVIYTIFNHDFR 449
Cdd:cd15191  204 KQRRDKVLKMVAAVVLA-FLICWFPFHvltFLDALARMGvinnCWVItviDKALPFAICLGFSNSCINPFLYCFVGNHFR 282

                 ...
gi 826349104 450 RAF 452
Cdd:cd15191  283 EKL 285
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
45-175 1.88e-05

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 46.21  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15406    8 LQLPLFLLFL--GIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQ 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVI 175
Cdd:cd15406   86 LFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIM 136
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-182 1.91e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 46.35  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  46 QVTLTLVCLVgllMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYL 125
Cdd:cd15387    1 KVEVTVLALI---LFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVK 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRriKAIIVTvWVISAVISFP 182
Cdd:cd15387   78 YLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDR--VYVLFS-WLLSLVFSIP 131
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
57-249 2.04e-05

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 46.34  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVM-GYWYFGKAWCEIYLALDVLFCTS 134
Cdd:cd15921    9 LIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLlVCTL--PLRLTYYVLnSHWPFGDIACRIILYVLYVNMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 135 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPPAEPRceiNDQKWYV-- 212
Cdd:cd15921   87 SIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLELA---HDAVDKLll 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 826349104 213 ---ISSCIGsFFAPCLIMILVYVRIYQIAKRRT----RVPPSRR 249
Cdd:cd15921  164 inyVTLPVG-FVVPFMTVIFCYIFIIKNLLKPSpalgRTRPSRR 206
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
58-157 2.83e-05

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 45.95  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLF-LV-SLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15142   10 MFIFGVVGNLIAIVVLCKSRKEQKETTFYtLVcGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSG 89
                         90       100
                 ....*....|....*....|..
gi 826349104 136 IVHLCAISLDRYWSITQAIEYN 157
Cdd:cd15142   90 LSIICAMSIERYLAINHAYFYN 111
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
51-243 3.00e-05

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 45.56  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL--VATLVIPFSLANEVMGY----WYFGKAWCEI 123
Cdd:cd15342    2 AVVALGLTVsVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFagVAYLFLMFHTGPWTAKLslyqWFLRQGLLDT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLaldvlfcTSSIVHLCAISLDRYWSITqAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS---IEKKGSSGGQPPAE 200
Cdd:cd15342   82 SL-------TASVANLLAIAVERHQTIF-TMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGwncLCDLKRCSTMAPLY 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 826349104 201 PRCeindqkwYVISSCIGSFFApCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15342  154 SRS-------YLVFWALSNLLT-FLIMVAVYTRIFIYVRRKSQ 188
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
85-185 3.25e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 45.58  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  85 LFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN-LKRTPR 163
Cdd:cd15166   37 VYMMNVALVD-LIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKeLKNTPK 115
                         90       100
                 ....*....|....*....|..
gi 826349104 164 RIKAIIvTVWVISAVISFPPLI 185
Cdd:cd15166  116 AVLACV-GVWIMTLASTFPLLF 136
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
60-187 3.88e-05

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 45.10  E-value: 3.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPfslanEVMGYWYFGKAwcEIylALDVLFCTSSIVH- 138
Cdd:cd15950   12 VIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVP-----KMLSIFWLGSA--EI--SFEACFTQMFFVHs 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 139 --------LCAISLDRYWSITQAIEYNLKRTPRRIkAIIVTVWVISAVISFPPLISI 187
Cdd:cd15950   83 ftavesgvLLAMAFDRYVAICHPLRYSAILTSQVI-AQIGLAIVLRALLFMTPLTCL 138
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
58-181 4.10e-05

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 45.12  E-value: 4.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIV 137
Cdd:cd15940   10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 826349104 138 HLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15940   90 LLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSL 133
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
54-184 4.27e-05

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 45.07  E-value: 4.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFT-SRALKAPQNLFLVSLASADILVAtLVIPFSLANEVMG-YWYFGKAWCEIYLALdvLF 131
Cdd:cd15376    6 ILGVEFLVAVLGNGLALWLFVTrERRPWHTGVVFSFNLAVSDLLYA-LSLPLLAAYYYPPkNWRFGEAACKLERFL--FT 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 132 CT--SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPL 184
Cdd:cd15376   83 CNlyGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVL 137
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
50-181 4.46e-05

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 44.96  E-value: 4.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWY--FGKAWCEIYLA 126
Cdd:cd15237    1 ILLFILFLLIyLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTisFVGCAAQMFFF 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 127 LdvLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15237   81 L--ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSL 133
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
379-441 4.47e-05

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 45.15  E-value: 4.47e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 379 GRQNREKRFTFVLAVVIGVFVVCWFP--FFFTYTLTAVGCSVPRT------LFKFFFWFGYCNSSLNPVIY 441
Cdd:cd15200  195 AKQAGPQRAVKVLAVIVLVYTVCFLPsiLFALASLVAFKVSQCRSldlctqLFHGSLAFTYLNSALDPVLY 265
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
52-182 4.60e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 45.14  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLlMLLTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15219    4 VLLVVV-LVVSLLSNLLVLLCFLYSAELrKQVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETF 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISavISFP 182
Cdd:cd15219   83 LTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHS--LTFS 132
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
57-157 5.94e-05

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 44.73  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYL-ALDVLFCTSS 135
Cdd:cd15942    9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLfFFHFLGCAEC 88
                         90       100
                 ....*....|....*....|..
gi 826349104 136 IVHlCAISLDRYWSITQAIEYN 157
Cdd:cd15942   89 FLY-TVMAYDRFLAICKPLHYS 109
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
60-234 6.11e-05

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 44.56  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15231   12 LVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVI----SAV-------ISF-------------PPLISIEKKGSSgg 195
Cdd:cd15231   92 AVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCgflnSAVhtvltfrLSFcgsnqishffcdiPPLLKLSCSDTS-- 169
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 826349104 196 qppaeprceINDQKWYVISSCIGsfFAPCLIMILVYVRI 234
Cdd:cd15231  170 ---------LNEVLLLVASVFIG--LTPFLFIVISYVYI 197
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
54-242 6.20e-05

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 44.78  E-value: 6.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133
Cdd:cd14975    6 LLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQpPAEPRCEINDQK-WYV 212
Cdd:cd14975   85 ASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENG-MCKYRHYSDGQLvFHL 163
                        170       180       190
                 ....*....|....*....|....*....|
gi 826349104 213 ISSCIGSFFAPCLIMILVYVRIYQIAKRRT 242
Cdd:cd14975  164 LLETVVGFAVPFTAVVLCYSCLLRRLRRRR 193
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
51-248 6.93e-05

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 44.55  E-value: 6.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLmlltvfGNVLVIiAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWyFGKAWCEIYLALDVL 130
Cdd:cd14973    9 LLSLCGLV------GNGLVL-WLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATLMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRtPRRIKAIIVT-VWVISAVISFPPLISIEKKGSsggqPPAEPRCEindqk 209
Cdd:cd14973   81 SYTVGLSLLAAISTERCLSVLFPIWYRCHR-PKHLSAVVCAlLWALSLLLSVLESYFCGFLFW----KFNESACR----- 150
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 826349104 210 wYVISSCIGSFFAPCLIMIL----VYVRIYQIAKRRtrvPPSR 248
Cdd:cd14973  151 -TFNFLSALLFLLLFLVMCVssltLLIRVQCSSQRR---PPTR 189
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
51-176 7.65e-05

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 44.29  E-value: 7.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANevmgYW-------YFGkawCEI 123
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVN----LWgpdktisYVG---CAI 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVIS 176
Cdd:cd15434   76 QLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIG 128
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
51-244 8.17e-05

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 44.43  E-value: 8.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL--VATLVIPFSL----ANEVMGYWYFGKAWCEIY 124
Cdd:cd15101    3 VMGLGITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFagLAYFFLMFNTgpntRRLTVSTWFLRQGLLDTS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 LaldvlfcTSSIVHLCAISLDRYWSITqAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS---IEKKGSSGGQPPAEP 201
Cdd:cd15101   83 L-------TASVANLLAIAVERHISVM-RMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGwncLCAIDACSNMAPLYS 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 826349104 202 RCeindqkwYVISSCIGSFFApCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15101  155 RS-------YLVFWAISNLVT-FLVMVVVYARIFVYVRRRTNR 189
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
60-181 8.96e-05

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 44.24  E-value: 8.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15413   12 LTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15413   92 SAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVAL 133
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
375-450 9.91e-05

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 44.00  E-value: 9.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 375 SRWRGRQNReKRFTFVLAVVIgVFVVCWFPF-FFTY--TLTAVG----CSVPRTL---FKFFFWFGYCNSSLNPVIYTIF 444
Cdd:cd15189  199 TRCEDRNDS-KATALVLAVTL-LFLVCWGPYhFFTFldFLFDVGvldeCFWEHFIdigLQLAVFLAFSNSCLNPVLYVFV 276

                 ....*.
gi 826349104 445 NHDFRR 450
Cdd:cd15189  277 GRYFRR 282
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
47-181 9.92e-05

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 43.85  E-value: 9.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVglLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15411    1 VPLFVLFLV--IYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMY 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15411   79 FFIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSL 133
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
85-234 1.01e-04

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 44.07  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  85 LFLVSLASADiLVATLVIPFSLANEV-MGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPR 163
Cdd:cd15149   36 VYLKNIVFAD-LLMSLTFPFKILSDVeLGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVG 114
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 164 RIKAIIVTVWVISAVISFPPLISIEKKGSSGGQPP-AEPRCEINDQkWYVISS--CIGSFFAPCLIMILVYVRI 234
Cdd:cd15149  115 YSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKcARLKSELGIQ-WHKASNyiCVSIFWVVFLLLIIFYVAI 187
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
56-249 1.09e-04

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 43.97  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGN--VLVIIA-VFTSRALKAPQnLFLVSLASADIL-VATLviPFSLA---NEvmGYWYFGKAWCEIYLALD 128
Cdd:cd15147    8 SIIFVLGLIANcyVLWVFArLYPSKKLNEIK-IFMVNLTIADLLfLITL--PFWIVyyhNE--GNWILPKFLCNVAGCLF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLIS----IEKKGSSGGQppaepRC- 203
Cdd:cd15147   83 FINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMdstnTVKIDSGNFT-----RCf 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 204 ---EINDQKWYVIS--SCIGSFFAPCLIMI---LVYVR--IYQIAKRRTRVPPSRR 249
Cdd:cd15147  158 egyEKDNSKPVLIIhfIIIGLFFLVFLLILvcnLVIARtlLSQPVQGQRNAGVKRR 213
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
49-175 1.15e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 43.73  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIP-----FSLANEVMGYWYfgkawCEI 123
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPkmicdLLREHKTISFGG-----CMA 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVI 175
Cdd:cd15226   76 QIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWII 127
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
383-452 1.33e-04

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 43.63  E-value: 1.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 383 REKRFTFVLAVVI--GVFVVCWFPFFFTYTLTAVGCSVPRTLF--KFFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15342  201 RETVLGLMKTVVIilGAFVVCWTPGQVVLLLDGLGCESCNVLAyeKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
45-196 1.44e-04

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 43.64  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGllmlltVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMG-YWYFGKAWCEI 123
Cdd:cd14996    3 LPIIYSFLFVTG------VFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCS-AMPFQAAYFLKGfYWKYQSTQCRI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 Y-----LALDVLFCTsSIVHLCAISLDRYWSI------TQAIEYNLK----------RTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd14996   76 AnffgtLVIHVSMCV-SILILSWIAISRYATLmkhdsaTQKQSCYEKifyghflkrfRQPKFARYLCIYIWGVVLCIIIP 154
                        170
                 ....*....|....
gi 826349104 183 PLISIEKKGSSGGQ 196
Cdd:cd14996  155 VVVYYSVREADEDG 168
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
63-244 1.48e-04

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 43.48  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  63 VFGNVLVIIA--VFTSRALK-APQNLFLVSLASADILVAtlvipFSLANEVMGY---WYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15165   12 VLGLLLNLMAlwVFLFKIKKwTESTIYMINLALNDLLLL-----LSLPFKMHSSkkqWPLGRTLCSFLESLYFVNMYGSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFpPLISIEKKgssggqPPAEPRC--EINDQKW---Y 211
Cdd:cd15165   87 LIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSI-PIYSFHDK------PTNNTRCfhGFSNKTWskkV 159
                        170       180       190
                 ....*....|....*....|....*....|...
gi 826349104 212 VISSCIGSFFAPCLIMILVYVRIYQIAKRRTRV 244
Cdd:cd15165  160 IVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRP 192
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
61-194 1.48e-04

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 43.55  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL-VATLviPFSLANEVMG-YWYFGKAWCEIYLALDVLFCTSSIVH 138
Cdd:cd15157   13 LGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMfVSTL--PFRADYYLMGsHWVFGDIACRIMSYSLYVNMYCSIYF 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 139 LCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLisieKKGSSG 194
Cdd:cd15157   91 LTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLL----SKGTSK 142
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
374-452 1.56e-04

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 43.57  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 374 ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPF---FFTYTLTAVGCSVPRTLFKFFFW-----FGYCNSSLNPVIYTIFN 445
Cdd:cd15117  202 ARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFhlvSLLELVVILNQKEDLNPLLILLLplsssLACVNSCLNPLLYVFVG 281

                 ....*..
gi 826349104 446 HDFRRAF 452
Cdd:cd15117  282 RDFRERL 288
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
56-186 1.69e-04

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 43.43  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPfslanEVMGYWYFGKawCEIYLA--LDVLFCT 133
Cdd:cd15917    8 CAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVP-----KMLGIFWFNA--REISFDacLAQMFFI 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 134 SSIVH-----LCAISLDRYWSITQAIEYNLKRTPRRIKAI--IVTVWVISAVISFPPLIS 186
Cdd:cd15917   81 HSFTAmesgvLLAMAFDRYVAICYPLRYTTILTNTVVGKIglAILLRAVALIIPLPLLVR 140
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
47-163 1.73e-04

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 43.16  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVglLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
Cdd:cd15409    1 VPLFLVFLA--IYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFF 78
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPR 163
Cdd:cd15409   79 FFGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNR 115
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
85-239 1.76e-04

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 43.23  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  85 LFLVSLASADILVAT---LVIPFSLANEVmgyWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRT 161
Cdd:cd15365   37 VYLFNLSLSDLLYIVilpLWIDYLWNGDN---WTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 162 PRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGQP------PAEP-RCEINdqkwyVISSCIGsFFAPCLIMILVYVRI 234
Cdd:cd15365  114 IRTALSVSVAIWLLEICFNAVILTWEDSFHESSSHTlcydkfPLEDwQARLN-----LFRICLG-YLLPLLIILFCYWKI 187

                 ....*
gi 826349104 235 YQIAK 239
Cdd:cd15365  188 YQAVR 192
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
43-239 1.77e-04

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 43.26  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  43 YSLQVTLTLVCLvgllmlLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY------WYF 116
Cdd:cd15347    1 QVASIFIVILCC------IIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSGSVTFrltpvqWFI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 117 GKAWCEIYLAldvlfctSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIkAIIVTVWVISAVISFPPLISIEKKGSSGGQ 196
Cdd:cd15347   75 REGTAFITLS-------ASVFSLLAIAIERHVAITKVKLYGSDKNCRMV-LLIGACWVISIVLGGLPILGWNCIGNLEDC 146
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 826349104 197 PPAEPRceinDQKWYVIssCIGSFFAPCLIMILV-YVRIYQIAK 239
Cdd:cd15347  147 STVLPL----YSKHYIL--FVVTIFSIILLSIVIlYVRIYCIVR 184
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
380-452 1.88e-04

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 43.27  E-value: 1.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 380 RQNREKRFTFVLAVVI--GVFVVCWFPFFFTYTLTAVGCSVPRTLF--KFFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15101  198 IRNRDTMMSLLKTVVIvlGAFVVCWTPGLVVLLLDGLCCRQCNVLAveKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
57-185 1.90e-04

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 43.26  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPfslanEVMGYWYFGKAwcEIYLA--LDVLFC-- 132
Cdd:cd15222    9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLP-----TVLGIFWFNAR--EISFDacLAQMFFih 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 133 TSSIVH---LCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15222   82 TFSFMEssvLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPF 137
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
379-452 2.01e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 43.30  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 379 GRQNREKRFTFVLAVVIGVFVVCWFPFfftYTLTAVGCSVP-----RTLFKFFFWF-------GYCNSSLNPVIYTIFNH 446
Cdd:cd15355  228 GRVQSLRHGVLVLRAVVIAFVVCWLPY---HVRRLMFCYVSdeqwtTFLYDFYHYFymltnvlFYVSSAINPILYNLVSA 304

                 ....*.
gi 826349104 447 DFRRAF 452
Cdd:cd15355  305 NFRQIF 310
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
391-450 2.12e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 42.86  E-value: 2.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 391 LAVVIGVFVVCWFPFFFTYTLTaVGCSVPRTLFKFFFWFGY------CNSSLNPVIYTIFNHDFRR 450
Cdd:cd15351  205 LTILLGIFFLCWGPFFLHLTLI-VTCPTHPFCLCYFKYFNLfliliiCNSIIDPLIYAFRSQELRK 269
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
378-451 2.22e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 43.21  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 378 RGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVG--------CSVPRTLFKFFFW---FGYCNSSLNPVIYTIFNH 446
Cdd:cd15190  219 RKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMylgilpfsCGFDLFLMNAHPYatcLAYVNSCLNPFLYAFFDP 298

                 ....*
gi 826349104 447 DFRRA 451
Cdd:cd15190  299 RFRQQ 303
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
57-181 2.72e-04

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 42.71  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSI 136
Cdd:cd15936    9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15936   89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSI 133
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
371-452 2.72e-04

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 42.59  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 371 GAKASRWRGRQNR-EKRFTFVLAVVIGVFVVCWFPFF--FTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15340  208 DGKVQTTRPDQTRmDIRLAKTLVLILVVLIICWGPLLaiMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKD 287

                 ....*
gi 826349104 448 FRRAF 452
Cdd:cd15340  288 LRHAF 292
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
58-182 2.79e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 42.86  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  58 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIV 137
Cdd:cd15386   10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTY 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 138 HLCAISLDRYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15386   90 MLIMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILSLP 133
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
60-184 2.82e-04

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 42.72  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15951   12 AVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIF 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIkAIIVTVWVISAVISFPPL 184
Cdd:cd15951   92 VAMALDRYVAICNPLRHSTILTNSVV-AKIGLAVVLRGGILVSPH 135
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
47-185 2.96e-04

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 42.48  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVI--IAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15122    5 IFLLLAALLGLP------GNGFIIwsILWKMKARGRSVTCILILNLAVADGAV-LLLTPFFITFLTRKTWPFGQAVCKAV 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLI 185
Cdd:cd15122   78 YYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFV 138
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
54-174 3.09e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 42.43  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL--VATLVIPFSLANEVMGYWYfgkawCE-IYLALDVL 130
Cdd:cd15905    4 LSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLLtgVALPFIPGMSNESRRGYHS-----CLfVYVAPNFL 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 826349104 131 FcTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWV 174
Cdd:cd15905   79 F-LSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWA 121
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
51-187 3.13e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 42.58  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKA--W-----CEI 123
Cdd:cd15964    3 LRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAidWqtgpgCNT 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15964   83 AGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGV 146
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
63-255 3.19e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 42.56  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  63 VFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY------WYFGKAwcEIYLALdvlfcTSSI 136
Cdd:cd15346   15 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYkltptqWFLREG--SMFVAL-----SASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 137 VHLCAISLDRYWSITQAIEYNLKRTPRRIkAIIVTVWVISAVISFPPLIS---IEKKGSSGGQPPAEprceindQKWYVI 213
Cdd:cd15346   88 FSLLAIAIERYITMLKMKLHNGSNSFRSF-LLISACWVISLILGGLPIMGwncISALSSCSTVLPLY-------HKHYIL 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 214 SsCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAT 255
Cdd:cd15346  160 F-CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKAS 200
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
50-187 3.21e-04

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 42.54  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  50 TLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASAD-------ILVATLVIpfSLANEVMGY---WYFGkA 119
Cdd:cd15360    2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADlcmgiylLLIASVDI--RTKSQYYNYaidWQTG-A 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 120 WCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15360   79 GCAAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGI 146
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
54-234 3.50e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 42.51  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  54 LVGLLMLLTVFG---NVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15077    3 MSAFMLFLVIAGfpiNVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTvWVISAVISFPPLISIEKKGSSGGQPPAEPRCEINDQKW 210
Cdd:cd15077   83 GGMVSLWSLAVVAFERFLVICKPLGNFTFRGTHAIIGCIAT-WVFGLAASLPPLFGWSRYIPEGLQCSCGPDWYTTNNKW 161
                        170       180
                 ....*....|....*....|....*...
gi 826349104 211 ----YVISSCIGSFFAPCLIMILVYVRI 234
Cdd:cd15077  162 nnesYVMFLFCFCFGVPLSIIVFSYGRL 189
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
382-450 3.71e-04

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 42.45  E-value: 3.71e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 382 NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-------GCSVPRTL---FKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15381  204 QTERKATVLVLAVLLMFFICWLPFHIFTFLDTLhklglisGCRWEDILdigTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
52-181 4.02e-04

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 42.20  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  52 VCLVGLLM--LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIP-----FSLANEVMGYWYfgkawCEIY 124
Cdd:cd15939    2 ICFVVFLLiyLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPklivdLLSERKTISFNG-----CMTQ 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISF 181
Cdd:cd15939   77 LFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHST 133
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
45-163 4.85e-04

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 41.92  E-value: 4.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLvgLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIY 124
Cdd:cd15408   12 LQVLLFVVFL--LIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQ 89
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 826349104 125 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPR 163
Cdd:cd15408   90 LYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQR 128
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
51-187 5.09e-04

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 41.77  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT--LVIPFSLANEVMGYWYFGKAW-----CEI 123
Cdd:cd15359    3 LRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLylLLIASVDSQTKSQYYNHAIDWqtgsgCST 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 124 YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15359   83 AGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGV 146
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
377-452 5.29e-04

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 41.62  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 377 WRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFK------FFFWFGYCNSSLNPVIYTIFNHDFRR 450
Cdd:cd15114  193 WSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAASAPNSRLLANalkadpLTVSLAYINSCLNPIIYVVAGRGFRK 272

                 ..
gi 826349104 451 AF 452
Cdd:cd15114  273 SL 274
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
51-173 5.35e-04

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 41.70  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVW 173
Cdd:cd15433   83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISW 125
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
49-234 5.87e-04

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 41.70  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIaVFTSRA-LKAPQNLFLVSLASADILVAtlvipFSLANEVMGYWYFGK----AWCEI 123
Cdd:cd15163    1 LALMVINTLIFLVGIVLNSLALY-VFCFRTkTKTTSVIYTINLVVTDLLVG-----LSLPTRIVMYYSAGNcltcSFVHI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 124 YLALDVLFCtsSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSSGGqppaeprc 203
Cdd:cd15163   75 FSYFVNMYC--SILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASCCL-------- 144
                        170       180       190
                 ....*....|....*....|....*....|.
gi 826349104 204 eindQKWYVISSCigSFFAPCLIMILVYVRI 234
Cdd:cd15163  145 ----SKLFALTVF--EFFLPLLIITFFTIRI 169
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
49-173 6.56e-04

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 41.29  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFT-SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
Cdd:cd15935    1 LLLFVLVLACYAAILLGNLLIVVTVHAdPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVW 173
Cdd:cd15935   81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACW 126
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
378-451 7.42e-04

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 41.34  E-value: 7.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 378 RGRQNREKRFTFVLAVVIGVFVVCWFPFFFT---YTLT----AVGCSVPRTLFKF---FFWFGYCNSSLNPVIYTIFNHD 447
Cdd:cd15150  200 GVGKVSRKKVNVKVFIIIAVFFICFVPFHFAripYTLSqtrdVFDCTAKNTLFYVkesTLWLTSLNACLDPFIYFFLCKS 279

                 ....
gi 826349104 448 FRRA 451
Cdd:cd15150  280 FRNS 283
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
47-180 7.82e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 41.20  E-value: 7.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVglLMLLTVFGN-VLVIIAVFTSRaLKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYL 125
Cdd:cd15430    1 ILLFVLCLI--MYLVILLGNgVLIIITILDSH-LHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQM 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 826349104 126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS 180
Cdd:cd15430   78 YLSLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNS 132
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
60-180 7.95e-04

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 41.31  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15428   12 LMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVIS 180
Cdd:cd15428   92 SVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVS 132
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
391-452 8.41e-04

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 41.04  E-value: 8.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 391 LAVVIGVFVVCWFPFFfTYTLTAvGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15960  209 LSLILATFAFCWVPFA-VYSMVA-DSSYPMIYTYYLVLPAACNSVINPIIYAFRNPDIQKSL 268
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
51-243 8.47e-04

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 41.24  E-value: 8.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIA-VFTSRALKApQNLFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEI--YLAL 127
Cdd:cd15378    3 LPTMYSIEFVLGFIGNTIVILGyIFCLKNWKS-SNIYLFNLSVSD-LAFLCTLPMLVYSYSNGQWLFGDFLCKSnrYLLH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 128 DVLFctSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKK-----------GSSGgq 196
Cdd:cd15378   81 ANLY--SSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNlkdnvtkckdyASSG-- 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 197 ppaeprceiNDQKWYVISSCIG--SFFAPCLIMILVYVRIYQIAKRRTR 243
Cdd:cd15378  157 ---------DATNSLIYSLFLTvtGFLIPLCVMCFFYYKIALFLKNRNR 196
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
51-108 8.91e-04

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 40.90  E-value: 8.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104  51 LVCLVGLLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLAN 108
Cdd:cd15225    2 LLFVVFLLIyLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVN 60
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
63-182 1.00e-03

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 40.90  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  63 VFGNVLVIIA--VFTSRALK-APQNLFLVSLASADILVaTLVIPFSLaNEVMGYWYFGKAWCEIYLALDVLFCTSSIVHL 139
Cdd:cd15923   12 VLGLLLNILAlwVFCWRLKKwTETNIYMTNLAVADLLL-LISLPFKM-HSYRRESAGLQKLCNFVLSLYYINMYVSIFTI 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 826349104 140 CAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP 182
Cdd:cd15923   90 TAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIP 132
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
391-452 1.16e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 40.78  E-value: 1.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 391 LAVVIGVFVVCWFPFFFtYTLTAVGCSVPRTLFKFFFWFGYcNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15961  209 LAIILGTFAACWMPFTL-YSLIADYTYPSIYTYATLLPATY-NSIINPVIYAFRNQEIQKAL 268
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
45-185 1.22e-03

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 40.63  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  45 LQVTLTLVCLVGLLMlltvfgNVLVIIAVFTSRALKAPQNLFLVSLASADILVATlVIPFSLANEVMG-YWYFGKAWCEI 123
Cdd:cd15379    3 LPLVYSVVFLLGLPL------NAVVIGQIWATRQALSRTTIYMLNLATADLLYVC-SLPLLIYNYTQKdYWPFGDFTCRL 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 124 ylaLDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAII-VTVWVISAVISFPPLI 185
Cdd:cd15379   76 ---VRFQFYTNlhgSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVcGAVWLVVIAQCLPTFV 138
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
55-193 1.31e-03

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 40.60  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  55 VGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL------VATLVIPFSLANEVM-GYWYFGKAWCEIYLAL 127
Cdd:cd15363    7 VWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLmgvssaVLAGVDAFTFGSFAQhGAWWESGVGCQITGFL 86
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 826349104 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSS 193
Cdd:cd15363   87 SIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGAS 152
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
373-449 1.37e-03

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 40.52  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 KASRWRGRQNREKRftfVLAVVIGVFVVCWFPFFFTYTLTAVGC----SVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDF 448
Cdd:cd15115  185 QRGRFAKSQSKTFR---VIIAVVVAFFVCWAPYHIIGILSLYGDpplsKVLMSWDHLSIALAYANSCLNPVLYVFMGKDF 261

                 .
gi 826349104 449 R 449
Cdd:cd15115  262 K 262
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
57-108 1.39e-03

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 40.64  E-value: 1.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 826349104  57 LLM-LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLAN 108
Cdd:cd15234    8 LSMyLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVN 60
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
373-450 1.53e-03

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 40.53  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 373 KASRWRgRQNREKRFTFVLAVVIGVFVVCWFPFFFT---YTLTAVG----CSVPRTLF---KFFFWFGYCNSSLNPVIYT 442
Cdd:cd15151  196 KKSRSK-DNKASKKTKAKVFIIVAVFFVCFAPFHFVrvpYTLSQTGkitdCQLQNLLYiakEITLWLAATNVCLDPLIYI 274

                 ....*...
gi 826349104 443 IFNHDFRR 450
Cdd:cd15151  275 FLCKSFRQ 282
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
56-185 1.58e-03

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 40.23  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
Cdd:cd15956    8 CFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAME 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 826349104 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIK--AIIVTVWVISAVISFPPLI 185
Cdd:cd15956   88 SGVLVAMALDRFVAICNPLHYATILTLEVVAkaGLLLALRGVAIVIPFPLLV 139
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
381-459 2.18e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 39.85  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 381 QNREKRFTFVLAVVIGVFVVCWFPF--FFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCR 458
Cdd:cd15084  215 QRAEKEVTRMVIAMVMAFLICWLPYatFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELLCC 294

                 .
gi 826349104 459 G 459
Cdd:cd15084  295 G 295
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
60-187 2.19e-03

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 39.96  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWY--FGKAWCEIYLALdVLFCTSSIV 137
Cdd:cd15224   12 VLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSisFVGCMTQLYFFL-SLACTECVL 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 826349104 138 hLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15224   91 -LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFI 139
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
85-175 2.30e-03

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 39.90  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  85 LFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRR 164
Cdd:cd15155   37 IFMTNLAVSD-LLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRN 115
                         90
                 ....*....|.
gi 826349104 165 IKAIIVTVWVI 175
Cdd:cd15155  116 SAIVCAGVWIL 126
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
381-458 2.92e-03

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 39.50  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 381 QNREKRFTFVLAVVIgVFVVCWFPF---FFTYTLTAVG-------------CSVP-RTLFKFFfwfgYCnsSLNPVIYTI 443
Cdd:PHA02834 222 KNKTRSIKIILTVVT-FTVVFWVPFnivLFINSLQSVGlidigcyhfkkivYSIDiAELISFV----HC--CVNPIIYAF 294
                         90
                 ....*....|....*
gi 826349104 444 FNHDFRRAFKKILCR 458
Cdd:PHA02834 295 VGKNFKKVFKNMFCR 309
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
61-253 3.31e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 39.38  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVipfsLANEVM-GYWYFGKAWCEIYLALDVLFC--TSSIV 137
Cdd:cd15102   13 FIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAY----LANILLsGARTLRLSPAQWFLREGSMFValSASVF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 138 HLCAISLDRYWSITQAIEYNLKRTpRRIKAIIVTVWVISAVISFPPLISIEKKGssggqppAEPRCEIN---DQKWYVIs 214
Cdd:cd15102   89 SLLAIAIERHLTMAKMKPYGASKT-SRVLLLIGACWLISLLLGGLPILGWNCLG-------ALDACSTVlplYSKHYVL- 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 826349104 215 SCIGSFFAPCLIMILVYVRIYQIAKRRTR-VPPSRRGPDA 253
Cdd:cd15102  160 FCVTIFAGILAAIVALYARIYCLVRASGRkATRASASPRS 199
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
375-441 3.50e-03

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 39.26  E-value: 3.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 826349104 375 SRWRGRQNREKR-FTFVLAVVIgVFVVCWFP-------FFFTYTLTAVGCSVPRTLFKFFFW---FGYCNSSLNPVIY 441
Cdd:cd15201  194 GRQLDRHAKIKRaVQFIMVVAI-VFIICFLPsnvtriaIWILKHTSNEDCQYYRSVDLAFYItisFTYFNSMLDPVVY 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
51-187 3.52e-03

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 39.22  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEV--MGYWYFGKAWCEIYLALD 128
Cdd:cd15913    3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLseTKTISFSGCFLQFYFFFS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 129 vlFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISI 187
Cdd:cd15913   83 --LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLI 139
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
47-192 3.55e-03

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 39.32  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  47 VTLTLVCLVGLLmlltvfGNVLVIIAVF-----TSRALkapqnLFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWC 121
Cdd:cd15152    5 VTYTVILIPGLI------GNVLALWVFYayvkeTKRAV-----IFMINLAIAD-LLQVLSLPLRIFYYLNKSWPFGKFLC 72
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 122 EIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN--LKRTPRRIKaiiVTVWVISAVISFP-PLISIEKKGS 192
Cdd:cd15152   73 MFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNdcKRKCDVYIS---IAGWLVVCVGCLPfPLLRQSQDTN 143
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
51-252 3.60e-03

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 39.06  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLA------NEVMGYWYFGKawceiy 124
Cdd:cd15211    2 LSTVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVlgstgtLLVLGYRLFRE------ 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 125 lALDVLFCTSSIVHLCAISLDRYWSITQA-IEYNLKRTPRRIKAIIVTVWVISAVISFPPLisiekkgssGGQPPAEPRC 203
Cdd:cd15211   76 -GLLFLGLTVSLLSHSLIALNRYVLITKLpAVYQALYQKRNTEWMIALSWALALGLLLPWL---------TSFRYPTKSC 145
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 826349104 204 EINDQKWYVISSCIGSFFAPCL----------IMILVYVRIY---QIAKRRTRV---------PPSRRGPD 252
Cdd:cd15211  146 HDSADGSFAVVSVLSSRYPALLlaftvlgqtaLVLHCYFGIFrrvQISVKRVSVlnfqivnnlPYSRPRKD 216
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
49-174 4.45e-03

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 38.92  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  49 LTLVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALD 128
Cdd:cd15429    1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFIS 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 826349104 129 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWV 174
Cdd:cd15429   81 LALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWT 126
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
391-451 4.52e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 39.00  E-value: 4.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 391 LAVVIGVFVVCWFPFFFtYTLTAVGCS---------VPRTlfkfffwfgyCNSSLNPVIYTIFNHDFRRA 451
Cdd:cd15100  209 LALILGTFAACWIPFAV-YCLLGDGSSpalytyatlLPAT----------YNSMINPIIYAFRNQDIQKV 267
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
68-186 4.52e-03

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 39.01  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  68 LVIIAVFTSRALKAPqnLFLVSLASADiLVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRY 147
Cdd:cd15153   22 LWVLCRFISKKNKAI--IFMINLAVAD-LAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRC 98
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 826349104 148 WSITQAieYNLKRTPRRIK-AIIVTVWVI--SAVISFPPLIS 186
Cdd:cd15153   99 FFLLHP--FKARDWKRRYDvGISAAVWIVvgLACLPFPLLRS 138
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
57-242 4.76e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 38.73  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  57 LLMLLTVFGNVL--VIIAVFTSRALKAPQNlFLVSLASADILVATLVI--PFSLANEVMGYwYFGKAWCEIYLALDVLFC 132
Cdd:cd15919    9 LLLCLGLPANILtvIILSQLVARRQKSSYN-YLLALAAADILVLFFIVfvDFLLEDFILNK-QMPQVLDKIIEVLEFSSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 133 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFP----PLISIEKKGSSGGqppaeprceindQ 208
Cdd:cd15919   87 HTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPyywwPNIWIEDYTSTSM------------H 154
                        170       180       190
                 ....*....|....*....|....*....|....
gi 826349104 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRT 242
Cdd:cd15919  155 HVLIWIHCFTVYLVPCSIFFVLNSIIVYKLRRKS 188
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
368-451 5.08e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 38.61  E-value: 5.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 368 RGGGAKASRWRGRQnREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFW---FGYCNSSLNPVIYTIF 444
Cdd:cd15349  185 RASGQRVISARSRR-RSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRSCKPLFGMEWvlaLAVLNSAINPLIYSFR 263

                 ....*..
gi 826349104 445 NHDFRRA 451
Cdd:cd15349  264 SLEVRRA 270
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
66-183 5.26e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 38.65  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  66 NVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLD 145
Cdd:cd15076   18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 826349104 146 RYWSITQAIEyNLKRTPRRIKAIIVTVWVISAVISFPP 183
Cdd:cd15076   98 RYIVICKPFG-NFRFGSKHALGAVVATWIIGIGVSLPP 134
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
385-452 5.67e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 38.72  E-value: 5.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 826349104 385 KRFTFVlavvIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGY-CNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15137  220 KRFFLI----VLTDFLCWIPIIVIGILALSGVPIPGEVYAWVAVFVLpINSALNPILYTLSTPKFRKKL 284
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
385-452 5.85e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 38.69  E-value: 5.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 385 KRFTFVLAVVIGVFVVCWFPFfftYTLTAVGCSVPR-----TLFKFFFWFG-------YCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15356  209 QHSVQVLRAIVIAYVICWLPY---HARRLMFCYVPDdawtdSLYNFYHYFYmltntlfYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
51-163 6.29e-03

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 38.55  E-value: 6.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
Cdd:cd15415    3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82
                         90       100       110
                 ....*....|....*....|....*....|...
gi 826349104 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPR 163
Cdd:cd15415   83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKR 115
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
61-188 6.59e-03

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 38.31  E-value: 6.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIpfslaneVMGYW---YFG------KAW-----CEIYLA 126
Cdd:cd15965   13 VTCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGIYLF-------VIGAFdlkYRGeynkhaQLWmdstqCQLVGS 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 826349104 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYnLKRTPRRIKAIIVTVWVISAVISFPPLISIE 188
Cdd:cd15965   86 LAILSTEVSVLLLTYLTLEKYICIVYPFRC-LTPGKCRTITILILIWIIGFIIAFIPLSNKE 146
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
380-452 7.06e-03

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 38.47  E-value: 7.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 826349104 380 RQNREKRFTFVLAVVI--GVFVVCWFPFFFTYTLTAV--GCSVpRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15344  198 RRNRDTMMSLLKTVVIvlGAFIICWTPGLVLLLLDVCcpQCDV-LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
51-249 7.36e-03

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 38.27  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  51 LVCLVGLLMLLTVF-GNVLVIIAVFTSRALKAPQNLFLVSLASAD-ILVATLVIPFSLANEvmgYWYFGKAWC---EIYL 125
Cdd:cd14989    2 LSCLYTIFLFPIGFiGNILILVVNLSFREKMTIPDLYFVNLAVADlILVADSLIEVFNLNE---KYYDIAVLCtfmSLFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 126 ALDVLfctSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGSsgGQPPAeprC-- 203
Cdd:cd14989   79 QINMY---SSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHT--GEVHF---Cfa 150
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 826349104 204 EINDQKWYVISscIGsFFAPCLIMILVY---VRIYQIAKRRTRVPPSRR 249
Cdd:cd14989  151 DVREIQWLEVT--LG-FIIPFSIIGLCYsliVRVLVRAQKHRRLRPRRQ 196
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
385-452 8.15e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 38.00  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 385 KRFTFVLAVVIGVFVVCWFPFfftYTLTAVGCSVPRT-----LFKFFFWF-------GYCNSSLNPVIYTIFNHDFRRAF 452
Cdd:cd15130  205 RRGVLVLRAVVIAFVVCWLPY---HVRRLMFCYISDEqwttfLFDFYHYFymltnalFYVSSAINPILYNLVSANFRQVF 281
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
82-251 8.26e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 38.25  E-value: 8.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  82 PQNLFLVSLASADIL----VATLVIPFSLANevmgYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
Cdd:cd15374   34 PTTVYMFHLALSDTLyvlsLPTLIYYYADHN----HWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRAL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 158 LKRTPRRIKAIIVTVWVISAVISFPPLISI---EKKGSSGGQPPAEPrcEINDQKWYVISSCIGSFFA-PCLIMILVYVR 233
Cdd:cd15374  110 RWVKPRHAYLICASVWLVVTVCLVPNLIFVttsRKDNITLCHDTTRP--EEFDHYVHYSSAVMVLLFGiPCLVIVVCYGL 187
                        170
                 ....*....|....*...
gi 826349104 234 IYQIAKRRTRVPPSRRGP 251
Cdd:cd15374  188 MARRLCKPRVGSSRQQGP 205
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
60-178 8.90e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 37.80  E-value: 8.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  60 LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLAN-----EVMGYwyfGKAWCEIYLaLDVLFCTS 134
Cdd:cd15228   12 LCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYlwgqsRVISL---GGCMSQVFF-YHFLGSTE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 826349104 135 SIVHlCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAV 178
Cdd:cd15228   88 CLLY-TVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSF 130
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
61-256 8.97e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 37.88  E-value: 8.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104  61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL--VATLVIPFSLANEVM----GYWYFGKAwcEIYLALdvlfcTS 134
Cdd:cd15345   13 FIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLagIAYKVNILMSGKKTFslspTQWFLREG--SMFVAL-----GA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 826349104 135 SIVHLCAISLDRYWSITQAIEYNLKRTpRRIKAIIVTVWVISAVISFPPLISIEkkgSSGGQPPAEPRCEINDQKWyvIS 214
Cdd:cd15345   86 STFSLLAIAIERHLTMIKMRPYDANKR-YRVFLLIGTCWLISVLLGALPILGWN---CLDNLPDCSTILPLYSKKY--VA 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 826349104 215 SCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAATA 256
Cdd:cd15345  160 FCISIFIAILVAIVILYARIYILVKSSSRRVTNHRNSERSMA 201
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
383-444 9.76e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 37.87  E-value: 9.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 826349104 383 REKRFTFVLAVVigvFVVCWFPFFFTYTLTAVGCSVPRTLFKFF--FWFGYCNSSLNPVIYTIF 444
Cdd:cd15387  229 RTVKMTFVIVLA---YIVCWTPFFFVQMWSVWDPNAPKEASPFIiaMLLASLNSCCNPWIYMFF 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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