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Conserved domains on  [gi|795025650|ref|XP_011861679|]
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PREDICTED: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [Vollenhovia emeryi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_TAB2_TAB3 cd14362
CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins ...
 11-54 1.45e-18

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).


:

Pssm-ID: 270545  Cd Length: 42  Bit Score: 79.27  E-value: 1.45e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 795025650  11 IMQLFHELKQQFPALPDHVVSQCIAQNSHDRETCARSLRatQES 54
Cdd:cd14362    1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQ--KES 42
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
396-484 3.90e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795025650 396 AASDRNRSPLCQVEEHQKKL------VAEQLARKERLARELRAEKGRLEAMKKEVQALARPVDpsvSPQELTRKLRSEIY 469
Cdd:COG4372   28 ALSEQLRKALFELDKLQEELeqlreeLEQAREELEQLEEELEQARSELEQLEEELEELNEQLQ---AAQAELAQAQEELE 104

                         90
                 ....*....|....*
gi 795025650 470 MLQVECDRLAEEVDQ 484
Cdd:COG4372  105 SLQEEAEELQEELEE 119
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 548-571 7.60e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.22  E-value: 7.60e-03
                           10        20
                   ....*....|....*....|....
gi 795025650   548 SWVCNMCTFDNHPLMNKCEECDMP 571
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
 
Name Accession Description Interval E-value
CUE_TAB2_TAB3 cd14362
CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins ...
 11-54 1.45e-18

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).


Pssm-ID: 270545  Cd Length: 42  Bit Score: 79.27  E-value: 1.45e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 795025650  11 IMQLFHELKQQFPALPDHVVSQCIAQNSHDRETCARSLRatQES 54
Cdd:cd14362    1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQ--KES 42
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 11-44 1.27e-04

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 39.78  E-value: 1.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 795025650    11 IMQLFHELKQQFPALPDHVVSQCIAQNSHDRETC 44
Cdd:smart00546   2 NDEALHDLKEMFPNLDEEVIEAVLEANTGNVEAT 35
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
396-484 3.90e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795025650 396 AASDRNRSPLCQVEEHQKKL------VAEQLARKERLARELRAEKGRLEAMKKEVQALARPVDpsvSPQELTRKLRSEIY 469
Cdd:COG4372   28 ALSEQLRKALFELDKLQEELeqlreeLEQAREELEQLEEELEQARSELEQLEEELEELNEQLQ---AAQAELAQAQEELE 104

                         90
                 ....*....|....*
gi 795025650 470 MLQVECDRLAEEVDQ 484
Cdd:COG4372  105 SLQEEAEELQEELEE 119
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 413-488 4.08e-04

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 40.29  E-value: 4.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795025650  413 KKLVAEQLARKERLARELRAEKGRLEAMKKEVQALARpvDPSVSPQELTRKLR---SEIYMLQVECDRLAEEVDQWSDR 488
Cdd:pfam20492  36 AEELEEERRQAEEEAERLEQKRQEAEEEKERLEESAE--MEAEEKEQLEAELAeaqEEIARLEEEVERKEEEARRLQEE 112
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 548-571 7.60e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.22  E-value: 7.60e-03
                           10        20
                   ....*....|....*....|....
gi 795025650   548 SWVCNMCTFDNHPLMNKCEECDMP 571
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
 
Name Accession Description Interval E-value
CUE_TAB2_TAB3 cd14362
CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins ...
 11-54 1.45e-18

CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins; TAB2, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway. TAB3, also called mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, or TGF-beta-activated kinase 1-binding protein 3, is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. In summary, TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD).


Pssm-ID: 270545  Cd Length: 42  Bit Score: 79.27  E-value: 1.45e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 795025650  11 IMQLFHELKQQFPALPDHVVSQCIAQNSHDRETCARSLRatQES 54
Cdd:cd14362    1 DMQLFHELKQRFPEVPDAVVSQCMLQNNHNREACCAALQ--KES 42
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 11-44 1.27e-04

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 39.78  E-value: 1.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 795025650    11 IMQLFHELKQQFPALPDHVVSQCIAQNSHDRETC 44
Cdd:smart00546   2 NDEALHDLKEMFPNLDEEVIEAVLEANTGNVEAT 35
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
396-484 3.90e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795025650 396 AASDRNRSPLCQVEEHQKKL------VAEQLARKERLARELRAEKGRLEAMKKEVQALARPVDpsvSPQELTRKLRSEIY 469
Cdd:COG4372   28 ALSEQLRKALFELDKLQEELeqlreeLEQAREELEQLEEELEQARSELEQLEEELEELNEQLQ---AAQAELAQAQEELE 104

                         90
                 ....*....|....*
gi 795025650 470 MLQVECDRLAEEVDQ 484
Cdd:COG4372  105 SLQEEAEELQEELEE 119
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 413-488 4.08e-04

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 40.29  E-value: 4.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795025650  413 KKLVAEQLARKERLARELRAEKGRLEAMKKEVQALARpvDPSVSPQELTRKLR---SEIYMLQVECDRLAEEVDQWSDR 488
Cdd:pfam20492  36 AEELEEERRQAEEEAERLEQKRQEAEEEKERLEESAE--MEAEEKEQLEAELAeaqEEIARLEEEVERKEEEARRLQEE 112
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 548-571 7.60e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.22  E-value: 7.60e-03
                           10        20
                   ....*....|....*....|....
gi 795025650   548 SWVCNMCTFDNHPLMNKCEECDMP 571
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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