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Conserved domains on  [gi|795629438|ref|XP_011733610|]
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BCLAF1 and THRAP3 family member 3 isoform X1 [Macaca nemestrina]

Protein Classification

BCLAF1 and THRAP3 family protein( domain architecture ID 12173452)

BCLAF1 and THRAP3 family protein is an RNA processing factor that plays critical roles in maintaining DNA genomic stability, such as the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) and thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-651 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 687.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438    2 ARSRSRSPrwKHRSLSPVPRNAEHYKQRHSHG----HYGCEY---RKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSsnhSKDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438   75 EHRSP-----------SPNIRNSLENVYMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYkehernSYPQKVQGGYspdDH 143
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY------QYSPKQQGRY---HG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  144 RVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQriqeekysQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKD 223
Cdd:pfam15440 150 RGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  224 VE----RYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPEtssatkvSYDYRHKRPK-LSDGDQDFSDG 298
Cdd:pfam15440 222 KEqkdaRYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYDYRHKFEKkLAEFEKDFSDG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  299 RTQKYCKEeDRKYSFQKGP-VNRELDCFNTGRGRETQDGQVKEPFKP-SKKDSIACTYPNKNDVDLRSSNDKRKEKIKKE 376
Cdd:pfam15440 295 RTEKYEKE-DRKKFSSKISkGNRESDCFSEGRGRKTEEGQVEPSAKEkSKKDEIACTDSMENDVYLERFNDKKEEKSKKE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  377 GDCRKESN-SSSNQLDKSQKLSDVKPSPINLR---KKSLTVKVDVKKTV-NTFRVASSYSTERQMSHDLVAVGRKSENFH 451
Cdd:pfam15440 374 GDFRKEAElSSSSQHDDSREKPDVKESSPKSVfsiKRESTVKVDMDKFDeDLARPSSSLAQERQLSRDLVHSGKKDQEFR 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  452 PVFEHLDStQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDTHkADVNEITLNSDPEIHRRIDMSLAEL 531
Cdd:pfam15440 454 SIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMKSNKSPEIHRRIDMSPSAL 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  532 QSKQAVIYESEQTLI------KII-DPNDLRHDIERRRKERLQNEDEHIFHIasaaeREDQSSSFSKVKNVHTDGFQKPM 604
Cdd:pfam15440 532 RKHRTLFEESKQSKEssykegKVKeDPNDLRHDIERRRKERLKERDEKRFHI-----RDSQDSRFSSLSRERTEKFQKPH 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 795629438  605 HFIKSNFKKciekpymnyTTQRKDIIThkpfqVEGNRRNTRV--RPFKS 651
Cdd:pfam15440 607 KFSKKNFRT---------SKKRRDRIT-----ISRSSSNSSSssRSFKA 641
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-651 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 687.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438    2 ARSRSRSPrwKHRSLSPVPRNAEHYKQRHSHG----HYGCEY---RKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSsnhSKDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438   75 EHRSP-----------SPNIRNSLENVYMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYkehernSYPQKVQGGYspdDH 143
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY------QYSPKQQGRY---HG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  144 RVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQriqeekysQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKD 223
Cdd:pfam15440 150 RGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  224 VE----RYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPEtssatkvSYDYRHKRPK-LSDGDQDFSDG 298
Cdd:pfam15440 222 KEqkdaRYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYDYRHKFEKkLAEFEKDFSDG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  299 RTQKYCKEeDRKYSFQKGP-VNRELDCFNTGRGRETQDGQVKEPFKP-SKKDSIACTYPNKNDVDLRSSNDKRKEKIKKE 376
Cdd:pfam15440 295 RTEKYEKE-DRKKFSSKISkGNRESDCFSEGRGRKTEEGQVEPSAKEkSKKDEIACTDSMENDVYLERFNDKKEEKSKKE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  377 GDCRKESN-SSSNQLDKSQKLSDVKPSPINLR---KKSLTVKVDVKKTV-NTFRVASSYSTERQMSHDLVAVGRKSENFH 451
Cdd:pfam15440 374 GDFRKEAElSSSSQHDDSREKPDVKESSPKSVfsiKRESTVKVDMDKFDeDLARPSSSLAQERQLSRDLVHSGKKDQEFR 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  452 PVFEHLDStQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDTHkADVNEITLNSDPEIHRRIDMSLAEL 531
Cdd:pfam15440 454 SIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMKSNKSPEIHRRIDMSPSAL 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  532 QSKQAVIYESEQTLI------KII-DPNDLRHDIERRRKERLQNEDEHIFHIasaaeREDQSSSFSKVKNVHTDGFQKPM 604
Cdd:pfam15440 532 RKHRTLFEESKQSKEssykegKVKeDPNDLRHDIERRRKERLKERDEKRFHI-----RDSQDSRFSSLSRERTEKFQKPH 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 795629438  605 HFIKSNFKKciekpymnyTTQRKDIIThkpfqVEGNRRNTRV--RPFKS 651
Cdd:pfam15440 607 KFSKKNFRT---------SKKRRDRIT-----ISRSSSNSSSssRSFKA 641
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-651 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 687.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438    2 ARSRSRSPrwKHRSLSPVPRNAEHYKQRHSHG----HYGCEY---RKDPKRPVAWRMDSEKHGQSKPRIPSRGNIYYQSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSsnhSKDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438   75 EHRSP-----------SPNIRNSLENVYMYKPHRGYSPGRGDSNRRAQYMPKYSEGIPYkehernSYPQKVQGGYspdDH 143
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRSPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY------QYSPKQQGRY---HG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  144 RVRGSGKGGKPPQRSIADSFRFEGKWHEDELRHQriqeekysQSTRRGSEDFETRSSFQKRYPEDRDFRKYGHTSKRPKD 223
Cdd:pfam15440 150 RGRGSPKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKRYPEEQDFRKYGHTSERGKE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  224 VE----RYESREPARNPKWKPEHSLPPYQEDTDQWNLGPQTYRHAEREHPEtssatkvSYDYRHKRPK-LSDGDQDFSDG 298
Cdd:pfam15440 222 KEqkdaRYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYDYRHKFEKkLAEFEKDFSDG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  299 RTQKYCKEeDRKYSFQKGP-VNRELDCFNTGRGRETQDGQVKEPFKP-SKKDSIACTYPNKNDVDLRSSNDKRKEKIKKE 376
Cdd:pfam15440 295 RTEKYEKE-DRKKFSSKISkGNRESDCFSEGRGRKTEEGQVEPSAKEkSKKDEIACTDSMENDVYLERFNDKKEEKSKKE 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  377 GDCRKESN-SSSNQLDKSQKLSDVKPSPINLR---KKSLTVKVDVKKTV-NTFRVASSYSTERQMSHDLVAVGRKSENFH 451
Cdd:pfam15440 374 GDFRKEAElSSSSQHDDSREKPDVKESSPKSVfsiKRESTVKVDMDKFDeDLARPSSSLAQERQLSRDLVHSGKKDQEFR 453

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  452 PVFEHLDStQNTENKPTGEFAQEIITIIHQVKANYFPSPGITLHERFSTMQDTHkADVNEITLNSDPEIHRRIDMSLAEL 531
Cdd:pfam15440 454 SIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMKSNKSPEIHRRIDMSPSAL 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795629438  532 QSKQAVIYESEQTLI------KII-DPNDLRHDIERRRKERLQNEDEHIFHIasaaeREDQSSSFSKVKNVHTDGFQKPM 604
Cdd:pfam15440 532 RKHRTLFEESKQSKEssykegKVKeDPNDLRHDIERRRKERLKERDEKRFHI-----RDSQDSRFSSLSRERTEKFQKPH 606

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 795629438  605 HFIKSNFKKciekpymnyTTQRKDIIThkpfqVEGNRRNTRV--RPFKS 651
Cdd:pfam15440 607 KFSKKNFRT---------SKKRRDRIT-----ISRSSSNSSSssRSFKA 641
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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